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<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPQ4</accession>
    <name>A0A2T4BPQ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1365912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPQ4"/>
    <dbReference type="STRING" id="983965.A0A2T4BPQ4"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="34"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="209" mass="23610" checksum="87B65D6BAF13DE29" modified="2018-07-18" version="1" fragment="single">MEPEKKKPSSKTSSTKDKRPKDKDESKTHKLSLKGSSRLVAEFFQYSIHTILFQRGVYPAEDFTAVKKYGLNMLVSADDQVKAYIKKIMSQLDKWMVGGKISKLVIVITDKDTGEHVERWQFDDKPEAEIQAEIAAIFRQITASVTFLPQLTGDCTFNVLVYADADSDVPVEWGDSDAKEIQNGERVQLRGFSTANHRVDTIVSYRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPV6</accession>
    <name>A0A2T4BPV6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1442790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPV6"/>
    <dbReference type="STRING" id="983965.A0A2T4BPV6"/>
    <dbReference type="OrthoDB" id="4899673at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015668282" evidence="2">
        <location>
            <begin position="26"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="248" mass="26265" checksum="CDEA655904BE5D3E" modified="2018-07-18" version="1">MRPVQITNALVFGLLGLAPIAASLSVPGSTDVERRYVGSGAALASKFVRSIIAELETRHHTEAQIAAKEAAAAKKGGKKHQAREADVADVPPDDEFGSWADKRAPHHTEAQIAAKEAAAAKKGGKKHQARHHTEAQIAAKEAAAAKKGGKKHQAREADVIHPDDEFGSWADKRAPHHTEAQIAAKEAAAQKKGGKKHQAREADVVPPDDEFGSWADKRAPHHTEAQIAAKEAAAAKKAGGKKPKNKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPW5</accession>
    <name>A0A2T4BPW5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_62568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPW5"/>
    <dbReference type="STRING" id="983965.A0A2T4BPW5"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="56"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="364" mass="40489" checksum="678A81AD934EA602" modified="2018-07-18" version="1">MGSEMDYSVFQLGDFRLVSGESLPNAFIAYKTFGDATSPAIIYPSWFSGAISDNEWLIGQDKALDPRRYFIIVPALFGNGQSSSPSNAPRETPLKPFPSITVKDNVTAQHRLVTEHLGVRHARMVLGWSLGAGQTYQWLTQYPDFMDLGVPFCGSARTSPHNQVFLEGVKSALLAAKGASSAGSAAGESAAMYRAWTDEEKVVGLKAFGRVYAGWGFSQAFYRDRVFETELGYKDLEDFMVNFWESWALSKDPENLLTMLHTWQAADCSDQEPYNKNLELAMKSIKAKTLVLPGETDLYFPPEDSEYEVQHMAKGVGQCIPFPSIWGHWAGGPGVSKEDVKWLDDHLKVLLDVKKWQLDTTGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ61</accession>
    <name>A0A2T4BQ61_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1406447</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ61"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ61"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="276"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="534"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="624" mass="69059" checksum="7AE7F7A3CDA91640" modified="2018-07-18" version="1">MSWNLTKKLKETHLGFKSSPSTKDKEKAKSGASTPSDANSVAERNSSEALSQEPVVKPTKPGILVLTLYEARGLSLPEQYQDALAASHPPGARSTGDALTGSSRTGTSRNPSAFSGSLDRPQSSSASGFKGIPTNHGRVSGKYMPYALVDFDKNQVFINSVDGNPENPVWAGSNTQYKFDVSRVGELTVQLFMRNPSAAAGTGRTQDIFLGAVRVMPRFEAVPETAPSGKKGQAERPQTQGHSGIGWFDLQNGTGKIQIGVNFVENRVGKLSIDDFDLLTLVGKGSFGKVMQVRKKDTGRIYAIKTIRKAKIITRSEVTHTLAERSVLAQINNPFIVPLKFSFQSPEKLYFVLAFVNGGELFFHLSKEGRFDINRSRFYTAELLCALECLHGFNVIYRDLKPENILLDYQGHIALCDFGLCKLEMKDEDSTNTFVGTPEYLAPELLKGEGYGKTVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILTAPLNFPGYDVVPPAARDLLTKLLERDPSKRLGVNGSTEIKSHPFFHGIDWKKLLQRKYEPAFKPNVTNALDTNNFDDLFKNEPAQDSVPDDFVLSKTMQDQFVNFSYNRPVAGLDDAGGSIKDPSFLEASETRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQC6</accession>
    <name>A0A2T4BQC6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1365523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQC6"/>
    <dbReference type="STRING" id="983965.A0A2T4BQC6"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="39"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="687" mass="75521" checksum="619166036D0A5250" modified="2018-07-18" version="1">MGESNMAGLGSVALNGSSPKKVAYFYDSDIGNYAYVTGHPMKPHRIRLAHSLIMQYGLYQKMEIYRAKPATRGEMTQFHTDDYIDFLQKVTPDNMDSYMREQGKYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRQKCDIAINWAGGLHHAKKCEASGFCYVNDIVLGILELLRFMKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDIGIGQGKNYAVNFPLRDGITDESYKSIFEPVIENVMKYFQPEAVVLQCGGDSLSGDRLGAFNLSMDGHANCVNFVKSFNLPTLVLGGGGYTMRNVARTWAFETGVLVGQEMDRALPYNEYYEYYAPDFELNVRASNMENSNSREYLEKITAAVIDNLRHTGPAPSVQMQDVPRKPFGGMTDEEEAELDDLDEDENKDVRMSERQWDKHVENGAEFDASDDEDMAAENGKTRGKGNKRTFTDFRTDEPEDKSERPSPVPAAAAAAATNGDAPQAPTVEDAHDINDDTIEDFAAAGEQEKASADKMDESKEPEKETEPEVEASKEDEPEKEKEPEKTTVDDDGDVGMADSEPKDEMTIKKEDVEPEPAPEHVPSKSPAAEEKPTEEPEAVATPAAPAEEAAAAAAAAVDEEPKATEAEPAKSPEAPSDAKEKEAETAEASADVDAMEVDQEKDEAEPKKASTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRP8</accession>
    <name>A0A2T4BRP8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1342914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRP8"/>
    <dbReference type="OrthoDB" id="4776075at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="111" mass="12917" checksum="13340AE5ECFD0190" modified="2018-07-18" version="1" fragment="single">KKKISKTYNSRCSLVVTHPTTNLPVSGLSMGEQTGPRVFHYLWSYVLENGGNSAHNGERESRERGRRFQLRFEIMAFCDVLHVSWNEGMDDWPLRDWYQPSGFSSFLLLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS14</accession>
    <name>A0A2T4BS14_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_22702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS14"/>
    <dbReference type="STRING" id="983965.A0A2T4BS14"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="900" mass="99638" checksum="CB39A1387C88D7A0" modified="2018-07-18" version="1">MDLPPAPTPPVSGGLGPNSDRTANLLNLLKFGGPGTSSKEPLQPSNQSQGQGQSQAHGQAQTQHQAPLPPSSSSTAQQHAEPSSQLHAQSQPLSAQQQQHQPARQNDEEDDDDDEDDEDEQRYRRLQLLQMQSSNQFSTRIHQPAPTADNPSGLLAALMRGAHELEEPKPAPTPPQAHVQPANPFGAGTPPANTTSYLLDLLRPKPSQTDQPQLHETSRSSQHTPQSQEHMSETSSRYYGHHHPQQQQQPQQQPVPQQQQQAASSYQAQPHYQQPADAFAGHGHGHGHPGINPIFSPTQKDQPDVSVLYQALAGTLNQMSPHSTGSVHGSAPPPFHILKKDQGSPAGSNPFGGSERSALQSPPQQFRHGLDRTSSLHSHHSHHSHHSHHSTQQSLKPTPPTSDFGSFVNIDKNRETVAEAVHDLASRADRDAQEALDRAERETVPNYAENATAKPHDESDWVQPSNYSDATRSTEKNTVEDIKSGYEHRGFGSSEERLSKDAPEEAREVDHHNIADSWESADQDEIVVIEEKEPASVKVYNFPMKPWISITLQEDATEPRPQFREESIMDVAHLKKDFDQIDRNLYTASQTYMTHGMSKQGGLRVIRQDDGKDAKVFRDTRDRIFNVAMSVTPNDYDGPAREAIIGTGISGTVYWVLIKDGEKDHLEDPHLEQYGFALPPINSQEGDAPGGALKTRARASTNHPDPHGSAAPSDHVGPVNNVTALAGAYASQMNRTEAEADNDLVQRIRVIEQAIAENRLQDAMIQWIQSGRETDIFRRCLSRYPPSKFDNLQPLMLLVVIATISKELRPNPRLKEEIEWIEMAVRAFGASLPNYNWDDDTSREIVKSTTQTMQLLINRVQPLIAGIQDGFPTDPFLANLERGKLDWIVQSSRHILNTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS56</accession>
    <name>A0A2T4BS56_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1099994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS56"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="22302" checksum="BD49DAA5674EBB68" modified="2018-07-18" version="1">MCNLPLGKECKLRPRMADMKQMTPLLPDVGSLKYSRRWRMASSPPSIADMLSRGYFSISFSIAFIISFFRFLYSLDSTRDLKPYAALLISTLVGESLGRCWTGLGKGGSSSTKVQLHKNISIPHNGLNLQERNGTLATDGGSSRYGQDALYRRLPEPLHTLMWRYIILIAFTLTTAASRRLQFLSTSLSDIMNSVQLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS88</accession>
    <name>A0A2T4BS88_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1099538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BS88"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="102"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="657"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="930"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1068"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1151"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1290" mass="145245" checksum="23399BC2089078E9" modified="2018-07-18" version="1">MQVFHVEKDHSGLNKCSSPEDPLYTELTEQLRRLQPNAPVKVNKTQQGVIDRLRPVIASDAEYHPSFDEHGRSRMECLPQTRVQLLNDICEWLDDFDSSQKHLYWLQGKAGTGKSTIACTIVSRMAKRKRIVANFFFKRGEGDRARLKRFFTTLSAQLVRKLPGFATAVKDALESEPSLPEQDPRIQFKKLIQEPLQKHNLGPHKAIVVVVDALDECDSKEDLANLVQQLLQPIVCIESAKSSSGQLLVKYFLTSRLDHHTQSDFNKVPENISEKAELEKATEDTTKRDIERYLKDKLGDINGFLDPLSNSDPWSNPADVEILKKLADRASPLFEFAAAACRYIEQPTVPGGPKVLIQDILDTNNYGDLDGVYLPILRRRFLKLKGTLYDRARTAFEDVIGSLVCLADSVTVPFLAKLLGQNELVVHHELLLFQSVLVVPKRQDSSLPISLFHESFRDFLIGSEANEEFKLDVQNIHARLATRCLEFLRGALRENICNLKSPGTYRSDVDEETIRTSISEEAQYACRFWIYHLRQGGFHLRDDDDWHSFLSFHFLHWVEALALLGRFSEVAPLMRQLETIIHPTEGAKLRAFLKDANRFIPYFGQIIDTAPLQIYSSALTFSPSESVIRKTFDACRSKWITRTPTVKTQWSPCVQTLEGHRQEVLSVTYSNRGILASGDRGGVVRIWDPQSGVCLQSSRILEDGGNGIMRRSYGISAMAFSTADKLACLTGKSIATWDESQHDCFRKLDYMLGLDSRTKGAVAFTDKQELLFTDAMRGRVLKSDLEHDPGIILSDSYARRIVLSFDGQWIAYLRPKRTTIFHMDTNDKHWPSALERWYMPEFGVESYDLSMGGCFSRDNRYFARYANGACVQIWDVAERKHLGVLEDTTTTSTVAFSPDGRLIATGNRYDGSITLWDWKAVEGATRLTILKGHRASINSLAFSPDGARLSSASTDRSVKIWDVSSESLKLFGEESDGIRHGDHISVAMDGQRFVTGPFGLRSKTYHLWDNYGEKCIALPLEHNIYAVISANGNVFAAFSFTDVKLWDVESGSHRPEIDGHCHISGSMILSAALSANGDRLVTGSLDGRVGLWETRTGRLLRESQRKRDKCPAVAISSDGEQVASSADFDIWVEDASGERFSGRDESSWQFVESLTFSPNGDRLASVTDKSVTTIWDLTTGARLRTFECDGLRLKPDFSWMLDRSFIDFDFAIATDLPENLPWHECLTKHYINNEGDWVMKHSQKLLWLPPEYRPKAAAAARSNIVIVRALGRPYLIGLSDDGLALDGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSG2</accession>
    <name>A0A2T4BSG2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1363785</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSG2"/>
    <dbReference type="STRING" id="983965.A0A2T4BSG2"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF4">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="157"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="479" mass="53164" checksum="C936DE2C40CF5C9E" modified="2018-07-18" version="1">MGADELTQIIGLKKTGQDEGITFTGRVHNLPRDEDGGSIALLLRKNGQFFKCQLKITDYADPSIFATAQCLTPESLVRISCGMIASDDASSETFTITQVSSLLILSEAKANIAGDLKLHGAPGETLLSLKERNLSLDTRLDNRLLDARVAATASIFKIFSAVHNLAVKHLAGLDFHYLPTPAFVGYEFPAEEEDHFYLDYLGRQAMLAPTGEVHLGMALAADLERVYDIHTVFRREPKSDGRHLTEFTMLELVFALDNDWAEILELADSLLVFLLRSLQEDDKIVKYTAAAQRLYPAAGSFKLGLDTNGKLPRVRFDEAQAILRDQLGKAAHVEEDLTREEETLLGDLFASDQSPLDSPTDVFIITHFPKHLRPCNVSSLGRDDWTTNSFDIILRGQEIVTGCQLLHSYKEVRAAFTNREHPIDPNCPGWRPYTEAHEIGMPPWGGFGLGLNRLVQGYLGLADVRETVLFPRDACRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTH0</accession>
    <name>A0A2T4BTH0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1405040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTH0"/>
    <dbReference type="OrthoDB" id="4897227at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="17081" checksum="4EEC544C9409E971" modified="2018-07-18" version="1">MPYANFPITPPATHISEVVDYYMLLIKLITEGIHPGSGEKGYSIAAAHKSSWWETMEALAKSLPAHGLDKEPTAAVRPSVELAEQALGFSSPYVQAAFGSRSACSLRHLEELLDLTGKRPAKCRGNKIQHCWELKWTDAGFFNIVDDEVQSVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTS3</accession>
    <name>A0A2T4BTS3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_7745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTS3"/>
    <dbReference type="STRING" id="983965.A0A2T4BTS3"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="226"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="471" mass="52109" checksum="F66EA5ED82D83673" modified="2018-07-18" version="1">MAPSRTDTETPTNGNHSSCQIPASEVIITGFTAHDLRFPTSLDLSGSDAMNPGPNYSAAYIVLHTNTSSPSSLSGHGFAFTIGRGNNLVVLAAEMLAERLVGKTLAQLTSNMGQTWRHLVSDSQLRWIGPEKGVIHLGLSACVNAVWDLWGRYLGKPVWEVVSDMTAEEFVRCIDFRYILDAITPEEALALLREQEKTKAGRLEEARRSRAVPAYTTQAGWLGFSDDKMVRLIESNLAQGMDKFKFKVGGNLEDDKRRLQIARDVIGYDRLLMVDANQVWSVPEAIDYMLHLVKYKPLFIEEPTSPDDILGHAAIRKALKPHGVGVATGEHCQNRVMFKQLLQAGSIDYCQIDACRLGGVNEVMAVLLMAKKFNVPIVPHSGGIGLNEYTQHLALINYLCVSGEKSLLEHISSFREVLNTPCQTKDGHFVTPREAGYSVEYKPEAIGKYTYPTGSFWRSEQGLAIINEPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTV3</accession>
    <name>A0A2T4BTV3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1465344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTV3"/>
    <dbReference type="OrthoDB" id="5153289at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="509" mass="58507" checksum="08C9BCE79588B3DE" modified="2018-07-18" version="1">MDMLQQPTKRATMPQRARYRPLPPPPPLPRASIRKSRLFIVESSPSPSPKRKRRPNEPQPRPLKRRQLHGHHPLRDAPPHDVLSVRASSVLQGALEDSLLHHRMAKPVAAWSEDDLYTWYGQYLEESDSRPRDPRTWREWRDDRRLDDEDKMLQKQLERWCVKCPLCLLHRDTRCNGHDLSECSRPERKLACLIERRLGGTLANIQLTGLRGYGEEWRQEKQGACQSYKWVVLRAVSAMLSFALPSGATLLQQAEAWRKDSRTHFNRELDLGGWLLSPMRWGSRQVVIMLRVFHQLDMAVEEAWVLKAVERRQVELNALGLQQWKDREAMASHDVVTADVKPTKLDIKVLNSMRGAARYHEEQRKHRLSCGRPDAYWREVRDRIREWGQGGIRCQLCRANRWSEQCYRHSASACSAWKESESYRMLVDKLSGLEGMGRGDGAGDGTCQRCMFPVQVCQLAAPEPSSIDSTADEWGACRGTEVMKQTVAALLMREGGALGTQVINQEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU80</accession>
    <name>A0A2T4BU80_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoaE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1405322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU80"/>
    <dbReference type="STRING" id="983965.A0A2T4BU80"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="274" mass="30599" checksum="5D38581441AEAABD" modified="2018-07-18" version="1">MLIIGLTGSIATGKSTVASLLASPPHSLPIVDADVLAREVVEPGTRGYRAIVRHFGPMAPDLLLPASDTMPENGPNGKGRPLNRAVLGRLVFGDEPQMQKNRAVLSGIVHPAVRLGMVKKVASCYLQGYWAVVLDVPLLFESRLDKFCGTTMVVAVTEPETQLKRLMDRNPDLSREDAENRVKSQMDVRLKAKRCLYAGEGKGVVLWNDGSKDELRAALDEEMRKLKEANPEWWAWLMLGFPPLAVALASWRFWQNIRLERQWREMQEKEAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUL4</accession>
    <name>A0A2T4BUL4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1425006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUL4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUL4"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="600"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="705"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="819"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="835" mass="92495" checksum="6B81E293762129CD" modified="2018-07-18" version="1">MNSTTTSMAALSPSISRRPSISSRVSFAVSHAEQGEAAGQAPREGQIEEEIAEIKRYEDFTTIDWVQDAAREQARRKARRKRTAGVYRLGQPGWRYRLWESYDAAQGWIVVTIIGAAIGLNAAFLNIVTEWLADIKTGHCTTAFYLNEKFCCWGEDNGCEQWHRWTGFGPLNYFIYFIFATLFACVSATLVKSYAPYAAGSGISEIKCIIAGFVMKGFLGFWTLLIKSICLPLAIASGLSVGKEGPSVHYAVCTGNVISRLFDKYRRNAGKTREILSACAAAGVAVAFGSPIGGVLFSLEEMSSYFPLKTMWRSYFCALVATAVLSTMNPFRTGQLVMFQVKYDRDWHFFEIIFYIIIGIFGGLYGAFVMKWNLRAQAFRKKYLTKYAVLEATLLAAGTAIIAYPNAFLRIDMTESMEILFLECEGAENYHGLCDKDKRAWNLVSLILATVLRVFLVIISYGCKVPAGIFVPSMAIGASFGRTVGIIVQAIHEANPSSVFFSACKPDEPCITPGTYAFLGAAAALSGIMHLTLTVVVIMFELTGALTYILPTMIVVGVTKMVSEMFGKGGIADRMIWFNGFPFIDSKEDHNYGVPVSHVMRSSVVSLPVSGLTLADVEQLLAETKYQGFPIVLDGSSKTLVGYIGRTELRYAVDRAKRERPVSQDAKCFFSPHPTTNQAPPITPITPNFRADVTASSPLDFSRYIDSTPVTVHPRLPLETVMELFQKIGPRVILIEYHGKLSGLVTVKDCLKYQFKVEAAENPKDDHHISEGQEHLWSALRRVGFWVSNSVSTVSRGHIRLSGQFDEERRAARRREGILDGDEDGVDEGVELERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUM9</accession>
    <name>A0A2T4BUM9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1404742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BUM9"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000652">
        <property type="entry name" value="Related to VPS15-ser/thr protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="827"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1431" mass="159420" checksum="C06F21AEAA219F8D" modified="2018-07-18" version="1">MGQGFSLATPSAGAAGIDIAQLQDIQYEKSIGNARFMKSIRGRHEHGVVLVKVLVKPYTEVKLDKYKKKIIEQRKALAGVPNALGFQRIIETETNGYLVRQFMYSSLYDRMSTRPFLVDIFSAGCVIAQLFLESEIFSLAQLYKYRRGEYDPVITHLSVISDKDVRDMIAHMIQLDPERRYSAEQYLDFWKDKVFPGYFYSFLHQYMEVITDPSSGNGPISGAERNLGESDNRIDRIFNDFDKISYFLGYQTEKQTAEPIKPKSRLGLDHFPVRLSIPSHEHAVSADLEPPEDDGTLIFLTLVVSAMRTTARAASRIRACDLLLAFAERLTDEAKLDRVLPYLMTLLRKEETDMVLVTVIRAVTQLLQLVRMTTPINSHVLVEYVLPRMEIALGTKSWTPNSLVRATYASCIGSLATTAQRFLEMASSLRADGSMPITDPEVEPGTDGAAANFESMFDNANRQLFEILESHTKQLVEDPDVHVRRAFLTSVPELCMYFQENSNDILLTHLITYLNDRDWMLKSAFLDTIVGIGAFIGGTSLEEFILPLMIQALADPEETVVRSALHSLAQLAGLGLLSRPKIWELTDLIGRLTMHPNMWIRESSAEFLSMAAKFLSKADVQCILLPLARPYLKIQHLSDFSELNLLDSLKRPLPRAVFDQALTWASKTDKGIFWKSVLGKRMSSSQGALTSAALIPSSTSKISRNEEDEQWLEKLRNFGLKPEDEMKFLALCEYIARLSSSKARDAVVVVAPAPEDENMPTGFVQLKELGVTIQTVFFDDTPLKDPSAVMPNLEPTPPVSGPYTIADALLDASMTIDDTLAKKKRAALNSHKRVHSIGPLPSRSTGRLLSPAGSDRASSIDSRALNSPLAPGDDAASYSSRRGIRHQSSALSLLDRRDGHKSIPEIGTSDANAFGEVEGPFTQTLPAQTISRPATEGGDTARLRQVRHSYEGTDPHVRRMLDNMYVENFPRDVLEFGPMVQPISGDKSRSVNAPGADPPWKPKGNLVATFAEHRGPINRVIASPDHVFFITGGNDGTVKVWDTQRLERNITNRSRQTYKHGDGARVVALCFVENSHCFVSCASDGSVHVVKVDTVPSSGIIRYTKLRVLREYQLPEGEYAVWCEHFKQEQNSVLIIATNLSRILAMDLRTMALLYVLENPVHHGTPTCFCVDKKRNWLCVGTSHGVIDLWDLRFKMRLKGWGVPGKGSIYRLCVHPTKGRGKWICVAGGTGQGEVTVWDLEKMTCREIYRTGGSKDGPKGYTPWEVDEDKPEGMLGRFATNLEMSDVANADRGVRAMVVGTGTSEESREVRHAFMLTGGSDKRLRFWDISRIENSCIYSGLQPDEQAPTYTSSHPTTSTTLNTERFARNAASAPNAGTGSRQKAPRSTVISMQQQQLLKSHLDLIMDVAILEYPYSMSVSVDRSGVVYVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUP4</accession>
    <name>A0A2T4BUP4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Xylanase regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1394263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUP4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUP4"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0858">Xylan degradation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="937" mass="102590" checksum="D08A030F01EE1146" modified="2018-07-18" version="1">MLSNPLRRYSAYPDISSASFDPSYHGPQSHLHSINVNTFSNSHPYPMQHLSQHAELSSSRMIRAGPVQPKQRQGSLIAGRKNSTGTAGPIRRRISRACDQCNQLRTKCDGLHPCAHCIEFGLGCEYVRERKKRGKASRKDIAAQQAAAAAAQQSGQAPDGPEDQHRKLSRQQSESSRGSAELAQPANDPPHGHVEGSVSSYSDNGLSQHAAMGGMDGLEDHHGHVGVDPALGRTQLEASSAIGLGPYGEVHPGYESPGMNGHVMVAPSFGAAQTTLPGYSGISYAAQAPSPATYSSDGNFRLTGHIHDYPLANGSSPSWGVSLASPSNQFQLQLSQPIFKQSDLRYPVLEPLLPHLGSILPVSLACDLIDLYFSSSSSAQMHPMSPYVLGFVFRKRSFLHPTNPRRCQPALLASMLWVAAQTSEASFLTSLPSARSKVCQKLLELTVGLLQPLIHTGTNSPSPKTSPVVGASALGVLGVAMPGSLNMESLAGETGAFGAIGSLDDVITYVHLATVISASEYKGASLRWWGAAWSLARELKLGRELPPGNPPANQEEGDGLSEDVDEHDLNRNNTRFVTEEEREERRRAWWLVYIVDRHLALCYNRPLFLLDSECSDLYHPMDDIKWQAGKFRSHDAGNIDSSMTDEFGDSPRAARGAHYECRGRSIFGYFLSLMTILGEIVDVHHAKSHPRFGVGFRSARDWDEQVAEITRHLDMYEESLKRFVAKHLPLATKDKEQHEMHDSGAVVDMQSPLSVRTNASSRMTESEIQASIVVAYSTHVMHVLHILLADKWDPINLLDDDDLWISSEGFVTATSHAVSAAEAISQILEFDPGLEFMPFFYGVYLLQGSFLLLLIADKLQAEASPSVIKACETIVRAHEACVVTLSTEYQRNFSKVMRSALALIRGRVPEDLAEQQQRRRELLALYRWTGNGTGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUP9</accession>
    <name>A0A2T4BUP9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1070428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUP9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="156" mass="17220" checksum="1A557635F6C0EC30" modified="2018-07-18" version="1">MATAAVRRCITYGLGAPTDCCILTGRILHFLNSLSPFLQTQDTGHSKETLRCTADTLLRDCCVVQYRITTWQAAHCVSLSTVVGDHPGTAIGWCARVVPDRQQLPQSHVMLRLMKMRPVLSLISQECLAPFENAVEHLERLLVPDRALAHSLLTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUQ9</accession>
    <name>A0A2T4BUQ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1070674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUQ9"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="42699" checksum="8FB5BC1A72738246" modified="2018-07-18" version="1">MVVGESGLGKSTLVNTLFNTSLYPPKERKAPSLDIIPKTVTIQSISADIEEAGVRLRLTVVDTPGFGDFVNNDESWRPIVDNIEQRFDAYLDAENKVNRVNIVDNRIHACVFFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKSDTLTDEEIAAFKARILADIKYHGIQIFEGPRYELDDEETIAENNEIMSKVPFAVVGATNEIKTPDGRKVRGREYPWGIIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNNLYENYRTDKLLAMGVSQDPSVFKEVNPAVKQEEERALHEQKLAKMEAEMKMVFQQKVAEKESKLKQSEEELYARHREMKEQLDRQRLELEDKKQRIESGRPIEKEGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUT5</accession>
    <name>A0A2T4BUT5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_141242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUT5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="216" mass="24134" checksum="99455D2D4AD01A2F" modified="2018-07-18" version="1">MKQMTQQLLIPNTLSFFATHSIIVAMVQGITRPAVGVETVPISTTRQVLFGTILPVVETRRKLEGTQDLWITTLLPSQFSTITSPNLLFSSPLYLALIFSIITLFFFLFPPFLLPSSPLTADTICPPARFIHLASLTAIRRRTHANQISSKSNHITRPDQTRPDQTKPNQTRPDQDQTPKAKFPPSPERSPPNIPSSEATTPTTPTRRFLILIHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV03</accession>
    <name>A0A2T4BV03_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1340458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV03"/>
    <dbReference type="STRING" id="983965.A0A2T4BV03"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="131"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="9">
        <location>
            <begin position="723"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125235" checksum="C83B262EE376A7BF" modified="2018-07-18" version="1">MSSAGNPADDDIGLVLENVNEDDFSFCALQHFEHNDFSQIPGVEPAPLDVTESLLWETPESPCAHCVLGGYSCKKIREGLQKGYCTSCVALGLECSFGGPVRPLGKPSFLDLMNLQTTGPVEDGVASAKAGTPPKIGARFSRESVRILKNWLSTHNRHPYPSDEEKEMLQRQTGLNKTQITNWLANARRRGKAQPPRSTSPHVGNLSSSIDIPRRRGTPALEAMNPLQRWEHSPPEHEPASVTAIARAVTASSSSGVSSGLNSPYSFNYTDDGSNRSLCNQSSASSVGTSHSSNGSLRSVFSHGSQNSWGSFGSAAFSSKGRRRRRRRAAPGKEPGSTSLSVPLKTFQCTFCTETFRTKHDWQRHEKSLHLSLERWVCAPDGPRAVNPDNGLLCCVFCGEVNPDDAHVETHNHSACQERSLEERTFYRKDHLNQHLRLVHNVKFMEWAMKPWKVATPEIRSRCGFCGIVMDTWTIRVDHLAEHFKTGYSMADWKGDWGFEVPVLDMVENSIPPYLIHHERKSPLPYNAGQSPPESPRNAYELIKLELAYFGSNFWDLHGRSPSDEDMMLEGCRIIFASELLSLQGIATQVSWLRDLIMSKDSIVKTARFGPLRGAAENRLQTLKINGKDNLFEECPMERQLHEYVKAKQLLGLTTMDDELQEEARKIVGRVEEVCTHPSEAVANWLLRLITSSTEWLAAFRRRAHLPRSEDVQHKSIRSKDPNSIDSTIHNYSRLESELVAFLKQQRSRGREPTDEELQRQARITIYEFDDGWNQTVADNHEWLAAFRQRNAPDQTTSPASKGAGATMSKSAEEASASLPCFAANPFSEFQSRLDENGNHHRSFQYFLNDANCYRRLEKELKRWVTSTMSKNNPNRHVPTDEELQYQARWILYDDDDPWNYTAADNAEWLHRFKRDTGIINDSGPGLPSGYAWALEQGGTGFAPPYAFLGDHDPVNNDVEVAMRNGAKPITAGHSAVNSYLEELTSSPNRKPAVIFCSRELEWGLQQYAKGYFMDKGVLPSDTALKAKAREILRAASTAADDPILLDKFKTWLLTRLPQLASGEPIRQEVDAVNTSPSAVPTNMDVNISDAELGDILKDMDFDFGLGTMEGIEHDGGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV60</accession>
    <name>A0A2T4BV60_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV60"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="195" mass="22452" checksum="86BC30FDE5C70BC5" modified="2018-07-18" version="1" fragment="single">KDFIYIPMEEQRTKESEHHELLAKYNDLSPSPQSAASLDDISEFNRGPTSSSAPIRPIVKIIQGKARRGARIYDGGENAKEDCGRVLDNQRKRKKSGECCRQGLRQISIPPPWPAEQAKHKAPVYHGSRRYQQQKHFARALSLLKQDRMPLVPRRPGFTRRKRPPTLIILRTFAELLWDDIESRRQSPSRQGVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVG1</accession>
    <name>A0A2T4BVG1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_128335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVG1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="186" mass="21179" checksum="948317AA0E6BB14D" modified="2018-07-18" version="1">MGARCWLRSCVWVPVPVPVRTRYGRYDWTHTQIERQSCARQAEQQLGQDQHVSHAASCSWPPHRTLHDIVPTDRSRVLLCLKTSISSIQPEPPDGSVDILLILLCHSKFLLGLSSPPRLTLTGVCASSSSQEQRKALVVERICNAHARLKHAAAPRRWSMRRCCARRLDDPAEAWYFRDIRYVDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVP8</accession>
    <name>A0A2T4BVP8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1060191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVP8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22114" checksum="4138DE245AD8D091" modified="2018-07-18" version="1">MDGEQPLPCIPDFAWSSTPGGRRLRGEGGRGCGFWGRGVCVCVCVCGRFGLALFGGHAGLPFVIFPSSFVFIQLFLFLFFIFFRFASPLSLFTSQGHIVMPFFFLTSEMRTHSVALFWSLCMLGPLPAQRTGVRIRPPTRKRTRPVRGQIAQVGKAKGAEARAKQGPSSMVTVRSHDDESIPSFQFQVVLSGPKGGVWCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVQ9</accession>
    <name>A0A2T4BVQ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1382471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BVQ9"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="54"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="523" mass="56510" checksum="FCB7A32C3EAC762A" modified="2018-07-18" version="1">MGTPEDTTSASSESDTHRPSNDLTDPEKQPVPAQETTAPPPPYSIYTTWQKRMLALGAACTAFFSPMSAQIYLPALTQLSEELHVSSTQINLTITTYMIFQGITPMVLGSLADSGGRRPAYIVCFVIYIAANIGLALAPNYGAILGLRCLQSAGSSTTVALCMAVVADVITSAERGQYVGYTVVPVVLAPAIGPILGGVLAQELGWRSIFWFLVIFAGVTLVLIYMFLPETCRHIVGDGSIYPPPLYRSGWQLLNSHRNKNRTAPPPENTFKFKPPNILGSLIMLLEKETGLLLGSSSLVFAGFYCISAAMPTLFKDSYGYDEITVGLMYLPLAVGSVLAALIVGPAINRNYKRYCQKLNIPLDRSRQQDLSNFPIERVRLEVGLPLLCISGLALIGWGWAMNYAVHVSVPCILSCIMGMGMIGFNNTTNTLLVDIHPGKAGTASAANNFSRCLVGAGATAAIVPLMDAIGVGWSFTMLGAIYIVCCAPLMVIMARGIRWRAELKAKHERKQARKQEKKGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW57</accession>
    <name>A0A2T4BW57_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1447143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW57"/>
    <dbReference type="STRING" id="983965.A0A2T4BW57"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="146"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="333" mass="36878" checksum="D6CD43534538AA01" modified="2018-07-18" version="1">MPMDQRELESRVKALTKVVAANEPPENALKLLELLKKDASPTEEMLRATRAGVFVGKLRSNPNKEIARAASELVIKWKKLVEQEKNSKLQKAKMGSPSAPAAASPPNNSSANAAAPAGAGKAYKGDPEKRKFDTDGVNIKRTESTVRNQCIGLIYNGLAYRSVESESSVIAKAVAVENAAFTAFNGEGAEYKKKIRSLFANLKNKSNRDLGKRVMSGDIAPERFVSMTDEDLKSDEQRRMELELEKENMKKAQVPMAEKSISDSLECGKCKKKRVSYTQAQTRSADEPMTTFCECMNCGNRWKVGFLVLLFHSLSCHLSLKLRCLHKVNLQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWK3</accession>
    <name>A0A2T4BWK3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1067240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWK3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="63" mass="7140" checksum="1895CB8AE1917FC1" modified="2018-07-18" version="1">MASDDHYSKMESPCMGQSMGSEHPFRLAVGMDDERCMMLPARASNVTPTAPHFSFCRSRFWPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX00</accession>
    <name>A0A2T4BX00_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1424431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX00"/>
    <dbReference type="OrthoDB" id="10369781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="16477" checksum="C97FDC8E4C9185EA" modified="2018-07-18" version="1">MSAPKTLPAIIWLKVFVRTNLARVSRKLRGDDDDNDAEAEDRFASDPPPAYERKPKSPPAEGEIAQLRHLLRAYEAGLEALPGDSLEGMMLLRDAESLRRWIDRLEDLHAERVGRTVPARLRREPYRDRIRRRIQSRGRTAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX49</accession>
    <name>A0A2T4BX49_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1360858</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX49"/>
    <dbReference type="STRING" id="983965.A0A2T4BX49"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="32"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="393"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB73897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="528" mass="57726" checksum="4E764E56C47E8DC1" modified="2018-07-18" version="1">MATAAQEHLETGGRINWLASLNTAFTPARNFRRTSIICTIGPKTNSVEALNKLRDAGLNVARMNFSHGSYEYHQSVIDNVRASVAAHPGRPVAIALDTKGPEIRTGNTAGDVDIPISAGTVMNFTTDEKYATACDTQNMYVDYKNITKVIQPGRVIYVDDGVLAFDVLSIKDDQTVEVRARNNGFISSRKGVNLPNTDVDLPALSEKDKADLRFGVKNNVDMVFASFIRRAQDIKDIRDVLGPEGKQIQIIAKIENRQGLNNFAEILEETDGVMVARGDLGIEIPAAEVFAAQKKMIAMCNIAGKPVICATQMLESMIKNPRPTRAEISDVGNAVTDGADCVMLSGETAKGNYPAESIHEMHEASLKAENTIPYVSHFEEMCTLVKRPVSTVESCAMAAVRASLDLGAGGIIVLSTSGDSARLLSKYRPVCPIFMVTRNPTTSRFSHLYRGVYPFLYPEQKPDFDTVNWQEDVDKRIKWAVTRAIELKTLTAGDTVVVVQGWKGGMGNTNTLRIVRADPDHLGIGQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX69</accession>
    <name>A0A2T4BX69_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_124613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX69"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="102" mass="10393" checksum="825960BF6CEF4993" modified="2018-07-18" version="1">MGRRPPAKQHGNAPQPAPSDLDLLLFALSFGFPSGPGGSLQLFGVSSQPPPLHCVSETRIAKCARRANEAAGSARNRGAPCRIGGSLGSGCVLGQLVCADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX88</accession>
    <name>A0A2T4BX88_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1440851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX88"/>
    <dbReference type="STRING" id="983965.A0A2T4BX88"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="413"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="539" mass="59700" checksum="0F1F4BDC62B21649" modified="2018-07-18" version="1">MPVPLPILLPAAAASLAYLNAKSSFWYDLALVKSVVKASLRVRHGLNHDTINLFYALESAALSRRLANKPFLIFEGKTHTYAQTYDRVLRYGHWIRKRFGVKPQEIVAMDFENSDTFIFVWFALWSIGAKPAFINYNLSGKPLAHCIKAATTRLCLIDPAVASKFEDESVKQSLPNVEFVVFTPEVEAEALATAPERAFNTDRSDGTMASMAMLIYTSGTTGLPKPAVVSWAKCIYGGTMAATLLNRGNGDIMYTCMPLYHSSAALLSVCATLLSGSTQALGRKFSTKRFWDECRASKATSIQYVGETLRYLLAAPPQLDPITGEDLDRKHNPGQPGEMLYRLPADDIGQRFQGYFNNPGASDAKILRSVFRPGDAWFRSGDVLRCDADGLTYFSDRIGDTFRWKSENVSTAEVSQAVGLHPAVREANVYGVELPHHDGRAGCAAVCLDPPVPDEATLRSLAAHVRASLPRYAQPLFLRLVRDVGVGSQTTGTNKQQKQSLRAEGVRPRETDVYWLRGDSYVPFREKDWRELEGGRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXU5</accession>
    <name>A0A2T4BXU5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1359685</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BXU5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="772"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="818"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="878"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="917"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1036"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="69"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="405"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="776"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1122"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB74138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1365" mass="146576" checksum="043122006C45B4BC" modified="2018-07-18" version="1">MAAHNDTAVPNGETEDVAVPRASNESKVDAISGAKGEPNKVSQFISGFFTYFQLLVYADPTWIDITLLVVGAISAAAAGVPFPLMGILFGQLVDDLNTASCDAKATTAADASRIQSSVDSKVLELTYIGIASFALIYIYIVCWSIFSRRLEARIRDRYFQALLRQDATFYDQRQAGELSSRLNADVQAVQSGTSEKVGICIACTSFFLTAYIVAFIKNWRLAAMLLSLIPAFFLMAGLGSKFSGKYTTAMSDAIGSASSIAQETLSNIAVVQAFGAGARLEAKFSSQMMNAQRKGIKKAFAAALQAGTLYFIAYAANALSFWQGSHQIVKTIADPSGVSVGQIYTVIFLLVDACVVFGSIAPLLPLLGGASTAFKKLRQDIETPAIINSGSDAGVKLPDSAAASISFRNVTFAYASRPDQPVLRNVSFDCPAGKFTSIVGLSGSGKSTVAGLATRIYDPQDGQVLLDGHDLRELNVKNLRSFISLVQQEPSLLDRSILENIALGLFNSPWEKHQKFQSIILGQGLAEVASKVRDGQDLTTVAQAHGQDMAELVEMVRNAASLADASGFIDRLESGYGTVVGTAGKLVSGGQRQRLAFARALIRDPKILILDEATASLDSASERRIQAAVESISEGRTIIAIAHRLSTIRNADNIIVMNNGQVIEQGTHLELMALDGSYAGMVRLQNLASQEQDDTPSMSSTSKGDADLPLSEKDAALDDVVPVSKEESAVSVSPEQQEASPEAAVGVGKELEGNQSTWNIVKSLGLMLRPHLLMLLLAVFSAVIVGGTFSSAGVIFGNTVSNVSPCNSTHHILWAGKFFGGLFFMLAVVELFAYTGSWFGFGYISEKLLYKIRVLTFRSLYEQELDWHQSEGRSPASLLSIITADAAAVGGFSGSIVGTMFSIVVNFLIAIILSHIIAWKIAIVCLVTVPILLGSGIMQVRALSQFERKHAGAFSTALGITVEAVTSFKTISSLSLEDEILHTYRRALKAPQRDTALASVYTNFWLAIANSIGNLIYAFAYWWGSTRITKGEYSQAQFLIILMAMLVSAQLWGQMFTLAPEVSRAKAAAARILNLINLGSSKRIGAKYTELAISSRGEKDVEATPNAGPSRVLNPNRGGATVTFRDVSFAYPARPHISILKNMSFTIPAGQFCGLVGPSGAGKSTIMSLVQRMYRPTGGVVEIDGVDICAREGVDFRHDIAVVPQDCALFDGTIKFNVGLGAVPGYEATDAEIEEACKLANIHDTIMTLSEGYETECGPNGSRLSGGQRQRLAIARALVRKPRLLLLDESTSALDAESEKALQKGLEQAARGITVIAITHRLHTVRKADVIFVVEGGQVVDKGRHEELVERSESYRINALQQMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY43</accession>
    <name>A0A2T4BY43_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1393349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY43"/>
    <dbReference type="STRING" id="983965.A0A2T4BY43"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="234" mass="26255" checksum="2B9304E298A19801" modified="2018-07-18" version="1">MSSLRAAQALRHSLRTRPLRSSFNTTRCLAATTTRMASSKAFFQGEPDAPVLKTKIPGAQSAKKIAELSEVFDTRAVNMMADYPKSTAGFYYGDPALRPNKPYRQFNTWMGDPARAILFRAIVEEIERLDLVNHTARVGDYLFAELERLQQQYPDHFQNLRGKGQGTFIAFDNPKRDQFLAKAKEFGVNIGGSGASAVRLRPMLTFQEHHADILVDALEKIVKALCLGSRYLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY89</accession>
    <name>A0A2T4BY89_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1337519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY89"/>
    <dbReference type="STRING" id="983965.A0A2T4BY89"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="23962" checksum="D8CD2F24C8914861" modified="2018-07-18" version="1">MYHLAKGLYLLATSKEEYSVILLGLDNAGKTTFHEQVKSMYLPNAPEPKLKTVPTVGQNVSTITLPDMYLKLWDVGGQHSLRKLWQSYYASCHAIVFIIDSTDIGDGDLAHDNNTGRLDECRLVLEDVLQHSETEGVPLLILANKQDREDCVETIRIKEGLVKRVMEGEKGAAIRDSRVLAMSALTGEGVREAIDWVRTRVQWNKESRPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ05</accession>
    <name>A0A2T4BZ05_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ05"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ05"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="502" mass="56306" checksum="71922E0E90E1BDFC" modified="2018-07-18" version="1">MHQVGVIPSSSSHPAVGEPALTGDGVSFQFPYHIFLLLLLIAPLVHTYRGHKRLARPRLSVRLLKVLSQLRYRAYSLIYNAILNCARPTLSINIFPRKVLVTDPSMESTLSRHTSETSLANVMFLIGRRVFGLSDGTINAIGSYDPRPVHVGEFSSASNVRALLAQVSATASQKLRGQPDVQETELGPWLFKLTSSSVASALWGPESPWVVDEEFQTQFMKISGSQMTLLRPFSRYTAQAAHKARALIIDRLRFFHFRNRDTRVRQIAHRINAVVMSDPNWESNKDYFNVELLTSLGLLVTPSSMAVWMIRHLLMRPDLFDRVVKEARDPSVLDAEGNIDVVRIRESFPFLAACLYETLRLHMTAIPRLAKTDFDLAVPNSQPVHLKSGDLIYLAMSSFNKDTATWGSDAGVFSPSKFLNNSGSLSASMIRKLRVFGVAGNLCPGRKLGFETILFVVAKMLRDFDIENPREEEAYPEPRTEDGFGIGFERCANEITVRLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZP5</accession>
    <name>A0A2T4BZP5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1380362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZP5"/>
    <dbReference type="STRING" id="983965.A0A2T4BZP5"/>
    <dbReference type="OrthoDB" id="5419928at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="3">
        <location>
            <begin position="321"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="698" mass="80860" checksum="8FFB8A3C248607E2" modified="2018-07-18" version="1">MTASAASVQFPFNNEPASQTRQFQAAAYSTLVEDGGRPSHPLCLLERIVYSPGRYSDILAYWQDRSDEWQVFHKQLSRWQAFRAHQGVSRDADGFEEYVLDLRERFDRHGFELPNGYRTPPNGLSFEMEKQSKVATWIEYINYELIRREEDEEWLETYRPSYDAALAQLMDAQVLEPFELVRTPTSDICSPSSSEIAKREAERRKAEDECEVAKRRMEGGFDSLKQTQVPQEMEEHERVYSEAMLRLKAINDRDWAISEFGRKSHAYRFAMDRLERHELLLRWAVNQIPLIEEEISHTGRRDAALRKGRRNWRLKQQAQTFPQFQRLPPEIRHRIWEEMLPKSPSVHFFDVLNCEHPCQLVPSWSSDEFRVRATRHRDSGYLPVYSLLATCRESRSIVEMYYIRRRRGVSCPLSGRPINFSDRPPDFRTFDWIPSDDLMVLCFPPVQVAQLPCENAFSLAPGPNQAARRLGLMIPRDLLSRTQFDPIDDGETDDGAAELALIPEFINHLHSEDSGPEADAALRGIWKLYLMVEGWSTNHIQMQLTAKIDSKRPVSDWADGIIHWRPPSAKRGGRMLPWNNQRIVHQPASESGGGARQLYWLGSSRPALGTLRPDDLVQERSAQKLHDFMQILEMQCRAQQWHHNFGGVEALGWLEPASGGSLDAAEVRELERATKRAGKWPGACERMKRERWDDEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C080</accession>
    <name>A0A2T4C080_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1337374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C080"/>
    <dbReference type="STRING" id="983965.A0A2T4C080"/>
    <dbReference type="OrthoDB" id="3928699at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="382" mass="42515" checksum="BFE65706E6965FCF" modified="2018-07-18" version="1">MPTFPCLDFDFKSPACIEWVSNDATQYLVDPDPQRGRVMFESRFANETSLASFQLHCPVRVKGIESQSHVICLIHTSSITSFEYNENPELPEVVRKKLNCKAIRLHFEFDQPLDLIAPAAATEPVQPRKRLSGQVFDSLRSLVKSSALDVYISDREVSQIKLTAVREAISGRKLKPLNADIPALLASLYGGRGGKVVKLSAPRDHSPASPNEEPPLYADLEPPPPPDGDHSPQPKSDILYQDPTAATGSSNKKRRRLDDSSTSSEPPGSFREILATLCHMREEMQRLAKRVDHLENENKGLREELDDLRASCEKATDDVESGELAVLELHDDLDELKEQVEFLAEGGLYSDAEEHLVETVTNSVLTHILDGGYNTKITFEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0A4</accession>
    <name>A0A2T4C0A4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1439626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0A4"/>
    <dbReference type="STRING" id="983965.A0A2T4C0A4"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="491" mass="56016" checksum="F3F24D0341CF8895" modified="2018-07-18" version="1">MKAKQGCWTCKQRKIGCDRDLPVCHNCTRTGRQCQGYGLRLLWPDRHDGRRKDSGFVLYEPPENPQEASKSYGVHFLNVTHNDVASSLDPTSYNALVTKAAAKPTRTLNLYPTMVGQDALFMSYYERVIAPMISTTQVQNGFRTDLVQMVLSRGDSATKALWNSMMAVAAFHHSGSAAALTYKTNAVRYLSASLTPGHETSSVDLNQTQFAASMMLCIYSVFDETDGHWTTHLDGAKYMLEGLYPEYRRQLRADFLFTWFLYHEVLACFSQPLRQAHNCIDVLFLLGASNCDATVILGALGCSLETIAIVHRINKFRIAIIQKEVDPLSPKLIQQRFELEHTLHNLVQRLDPEGEAGEVPARRTRILATAELYRIGTILYLLHVIPCPGDEEAKATYLNDFFDIVDRLGVATSPWPIFMVACECQTDEQRIRVLRILDLMNNVRNIGNIRVMRNLIETCWKHYDLQADSTYMHRTKWWEFIHYETAVPWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0A9</accession>
    <name>A0A2T4C0A9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_334854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0A9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="69" mass="7618" checksum="BC3FDB7767A3B835" modified="2018-07-18" version="1">MGDAKGGNLGVHNYGSKVDISGLYVVLCLRYLFIHCPGLYNPLLRRITRIGVYCSRSNEWTPSIFGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0S4</accession>
    <name>A0A2T4C0S4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1379172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0S4"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015551406" evidence="7">
        <location>
            <begin position="21"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="502" mass="53090" checksum="068FFA0426437299" modified="2018-07-18" version="1">MLASLIFGIFLIALDMTIVATSIPAITKEFNGLGDQAWYSAIYLMTSGGFQSTWGKMYQYFPLKISFLSAMAVFEIGSLICGVAPSSVTFIIGRTIAGVGAAGVSSGAYTICAYISEPKKRAVHTGILGAVFGVGSILGPLLGGVFSEESTWRWCFYINLPIGVLPIVSTVFFLSTPKDAKPREAPAKEKLLQLDPLGTAVLMGAIITYLMAVHYGGQIDPWNSARVIGLLAASVVLFVIFALVERWQDERAMIIPRLFAKRDIYVPLFYTVFQGGALFAMVYYLPLYFQAIRGTDAVISAVHNLPFIIAAMLSALGAGIFISNTGLATPVIIGGSAVATLGCGLCHLFDLDTETGVWIGIQIVVGLGLGCAFQVPIMVGQVSVDVADIPAVTAMILCFQTVGGAIWVSASQSIFVNRMLIAVPQFAPGVDPTQVVSTGAGELRDVFGPEQIVGVLTAYLTGIRAAYMLSCAVVGASLLVGMFLPWKRLDTDALKEAGGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C116</accession>
    <name>A0A2T4C116_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1358243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C116"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="484" mass="55558" checksum="BE4067DFF7FB6836" modified="2018-07-18" version="1">MDECIDNRLNRKSGFRHPAIQAATETRLLKISQDPASQSWQYDLVVVALDDLSSTPYRALSYTWGTAVSSEDVRTIRVNHQDLVIRRNLFDFLSSASAREEQGLFFIDAICINQLDLDERQAQVQAMALIYRRATAVISWLGILPQAHYRGCQTLSHASDVSFRKWSEQEWGALKYLCNAPYWSRVWVVQEVLLSSNLQIWCGPFNFSSTLLGRAPPSRDPIETKFDADGRPSVLKSDASRVRSPSEAILGHRTRLVTRMTKDTTREASVMGTLADITTVLRQPSATFETYQSRVPDELRDIIRKYGRLQCTDIRDRLYGFFGLLKDSSRKKIKPDYSKGVEYTFYQALKCGLGELCPEDGIAPWGLNAAWVDFYCEARDAFHVGDEAGIHIFRRVYRELNFKERMQDALFQQQWELNYGWRGPDAVRFGAFARMIVEDEHEETSSGAEGPALLKFHDKQRRLYEKLSMKIRRRPKASYSILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C198</accession>
    <name>A0A2T4C198_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1458886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C198"/>
    <dbReference type="STRING" id="983965.A0A2T4C198"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="317"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="630"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130267" checksum="DA9AF5502925C247" modified="2018-07-18" version="1">MPLMALVLGRLTANFTGFGSADNKQSTHDFMKQVQTNALYFVYLFIAKFSLVYIWSFGFGYSANRMVQALRLKCLNRVLNRTITAHDAQTPGALSNTITTHCNSIQSALSDRIGIMIQAFSMLLASFAVAFSQSWHLTLVMLGLVLMTLGLIGFIVGSDQKIEAGLLKKYTDCSAIAEDALGSIKTVVAFGAGPKFLAKYDAILEQAEADGKKRGPFVGLMFACQYFFMFTGWAIGFYLGAYLYKRGLISDPGRILSVFFAMLIGLGAIMALGPNMPSFIKAVAASGDVFKILDDTDKKDATDAFVVSSLGTRNGHLVMRDVSFSYPARPDVKALSDVNIEFVSGTSTAVVGPSGAGKSTLVSLLERWYQPTSGVILLDDYEITGIDPKWLRQQIALVEQQPQLFNASIFDNIAYGLIGTEKEHASREEKMRLVEEACQEARALDFINNLPKTFDTDVGDHGGLISGGQKQRIAIARALIGKRPILLMDEATSALDNENSKVIEKLMTASGDRTTIFISHKISSAMKADRIVVIDKGQVVEQGTHAELIAANKVYRRLHDAQLHDEADATEFTPLETSISELKPLTRGASTVPDSSPNELTEIPDIPKRSLWQNLYTIFKEQRRYLPILLIGIFSAIVTAQIFPVQAILLGRVMQSFQGTANEISSQANFWSLMFFVVGLGALIAYAVLGFFMTLLGIRLTRFYRLDYFRVILSQRMEFFDRVSSGALVSRLSTDPANLHELISVNLGLLISIFVSIISGSIIALAFSWKLALVAIFGAMPVVFAAGFIRMTLDSSLAEATAKVFEDSARFATDALSSIRTVKAFTMEDTVQDSYQQQLAVTMKRLSRKTAIITLFFAFSESAELLAAALGFWYGGKLLGNGETSTEKFFTVFIAVIVGGQAAGALFGFSSNISKARIAANNILGIRQHVHVPKEAAPSLDVSREKDANVVVEFKNVSFAYPARPNVTVFKNVSFQILKGQTVAVVGSSGSGKSTLLALLERFYDARSGALDVFGKPISSEEAEAYRKRLAIVPQEPTLYRGSIRDNIVLGVDEDKVKEEDVVSACDAAILTDLIASLPEGYNSDCGAKGVALSGGQKQRIAIARALIRNPEILLLDEPTSALDAESEQLVQETLQSIQGGRTMIIVTHRLNTIKTADVIIVMAAGQIVEQGTHSELMARQGHYFKMYQSSRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C293</accession>
    <name>A0A2T4C293_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1439386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C293"/>
    <dbReference type="STRING" id="983965.A0A2T4C293"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="225"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="572"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="668" mass="74642" checksum="5671695B093B8DA8" modified="2018-07-18" version="1">MRSLSLSNLLRHHKHATFSHDDPQPSRQTNDVAVDDSEDTHELPARNLRGRAQSTAGTIKGVIRRASLSLKGIVHRRPSITAEPADAHYQAVAHARPTSAHHTWNRLRQVAPFRRSRSFYGLHVTEDGLYEQRQGPNSHMPVPAMGDEPPYVPMNTGHAAKASVALQNEYFQRQAMHAQWLQSSSNEDSNDRESGIGIVVTEPFNGSRVSVNGSFPTQDSNISRIDFIKQLPSELAIHVLACLDAAALAKASVVSRHWHDVVRNQHIWRESCLREMTTTYATSEPVKPGSGLGIPPVVPTNDWKQIYRAKLELAQKWKEGKARPMYLNGHTDSIYCLQFDEYKIISGSRDKTIRIWDMQTLECRLVIGPPEVVNAPNLLEDAEGNPVHYVNFSDSFRAAPSMPKVVSFADHHRASILCLQYDDEIMVTGSSDSTCIVYDMRNGYRPIRRLTHHTAAVLDLAFDEKHIVTCSKDISICVWDRATGALLRQLRGHTGPVNAVQMRGNTIVSCSGDFRVKLWNIDTGRCIREFVGHTKGLACSQFSEDGRYVASAGNDKVIRIWDANTGECVREMRAHENLVRSLHIDSVSGRLVSGSYDTDIKVWDMETGRQLLDFPRWHASWVLSAKSDYRRIVSTGQDPKILIMDFGAEVEGIDMLKSGNTGVGGGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2P4</accession>
    <name>A0A2T4C2P4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1422929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2P4"/>
    <dbReference type="STRING" id="983965.A0A2T4C2P4"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="85"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="354" mass="37906" checksum="4425B08AE5B61B18" modified="2018-07-18" version="1">MSALNGAGHSSSSKATDHDGSNTPGFQPQNKMTVQPPRNEDLQVSYAAEIGGEANPKGWYGSMINSLGSCIGTMGAIPCCILCPNPYKHVNQGHVGLVTKFGRFYKAVDPGLVKVNPLSERLIQVDVKIQIAEVPEQTCMTKDNVTLRLTSVIYYHIVSPHKAAFGISNVRQALVERTQTTLRHVVGARVLQDVIERREEIAQSIGEIIEDVAAGWGVQVESMLIKDILFSQDLQDSLSMAAQSKRIGESKIIAAKAEVESAKLMRQAADILSSAPAMQIRYLEAMQAMAKSANSKVIFLPGSSQPLSGAAMNAALGDVGQSGEGSGGTGVNARDFGGQDNFQQAMNARMVENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3A7</accession>
    <name>A0A2T4C3A7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1392464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB76005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3A7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3A7"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="258" mass="29548" checksum="E66886E7A007669A" modified="2018-07-18" version="1">MSHFSYSSCIGALTVPTNDNILVPETLLKKRKSQEKARAERAAVVEKRKAANKEKRGVIFKRAEKYVQEYRNAEREKIRLRRAAKADDSAYIPAEAKLIFVVRIKGINKMPPKPRKVLQLLRLLQINNGVFLRVTKAITEMLKIVEPWIAYGYPNLKSVKELIYKRGYGKVDKQRVALTDNSIIEANLGKYGIICIEDLVHEIYTVGPNFKQAANFLWPFKLSNPTGGFRTRKFKHYIEGGDLGNREEAINALIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3E0</accession>
    <name>A0A2T4C3E0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1333891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3E0"/>
    <dbReference type="STRING" id="983965.A0A2T4C3E0"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34042" checksum="54B02DAF3D9CEF07" modified="2018-07-18" version="1">MDPKAVVAGTPIEAPRSYGKRIDGGFTPKPLPRPIGMALPPLPGENTGIDTRSLQQRKEDFVNYDKHLQRRKELTAKISRPYFRDWGNLQYHEGKSFIAPPRLFKAELSLFFPNLYGQTLLKDDKTPRDTTPLLSGRASVVSIFSSQWAERQVESFVSKEANPHLHEVLERSGETAQLVRINYEDNKGKAFLVKLFMGSLRKRFGEKEWDKYFLVQRGITDEIRESIGLLNSKVGYTYLVDHHCRIRWAGSGSSHPDEVESLNKGLAKLVEDIKKEASLPATAREKLPGKPHLEKAKESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3N1</accession>
    <name>A0A2T4C3N1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PSMD12/CSN4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1391709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3N1"/>
    <dbReference type="STRING" id="983965.A0A2T4C3N1"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PSMD12/CSN4-like N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="275" mass="29769" checksum="7F76B9E8B33C9F5C" modified="2018-07-18" version="1">MEPNPNVAAAIASAESASGDEKAAMAARYESILADLPSLASPAAPTAADLNAVFDSFFRQSPGLVASRAFLTTFVNTLKGIENEQLWIDVGTRTLDKLAAQPSSYFDAAATLYELLATAHENNDDFLDAAKALAEIPLDSSQRKVSDEDKARVWVRIVRNYLEVGDDTAADVYVNKLKNIMHTLLGLDAARAEETTARMIEQGRLVGRMDQLDGTVWFQGGEASGEKGSRRADVVANKEMRRWDANVEGLAEDVESVINSLQKEFPAFVAANLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4B0</accession>
    <name>A0A2T4C4B0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1422466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4B0"/>
    <dbReference type="OrthoDB" id="5594057at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02509">
        <property type="entry name" value="GDP-M1P_Guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049577">
        <property type="entry name" value="GMPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054566">
        <property type="entry name" value="ManC/GMP-like_b-helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22640">
        <property type="entry name" value="ManC_GMP_beta-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159283">
        <property type="entry name" value="Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="6">
        <location>
            <begin position="127"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP isomerase/GMP-like beta-helix" evidence="7">
        <location>
            <begin position="434"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="487" mass="52307" checksum="D52EBFD6BBDAEE16" modified="2018-07-18" version="1">MAATVSEAPKMGIEMMLERIMGAMEKQNQEMAELRRECADLRSSNKSMEIMLQSMVQQQGRNQSPTGLSAGMSPSLGRERARSPFLPRHSSSAPSGPSQALIASPSRELPIHSLSFTEREIPGFYVVIPAGGAGTRLWPLSRENHPKFLLDVNLCGNSLLQSTWDRLLPLAGPSRMTVVAGPAHSEGILGQLPNLDSSNLFTEPGPKDSMAAIGLAAAILLRRDPDAVIGSFAADHMISGEEAFLAAVTEAVEVAREGYLVTIGIAPSHPATGFGYIRLGDRLGLKTAPHSRLVSSFKEKPDAHTAAKYLATGQYRWNAGMFVTKASVLMELLKEHCPALYDGLTSISDVWDDEAARKVALEEVWPTLEKIPIDNAVAEPAAAQGKVAVIPATFGWDDVGDFSSLAEMLPAESNKPRVLGDQRLVVSEQTAGGIVVPVSGRLITCLGVDDIVIVDAPDALMVTTRARSQEVKSLVKKCREAGWKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4D5</accession>
    <name>A0A2T4C4D5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1439061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4D5"/>
    <dbReference type="OrthoDB" id="5426355at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="23700" checksum="ED3F2D046BE1F010" modified="2018-07-18" version="1">MAAQAPITTLVPFADRAQLPACAAACGHLYDANGACVPPAVPSNTPAAYTSCFCFDPRLAPFSTTTAGVCDNACTGDPNGFASITNWYHSVCNVQKGAAPTTSTSTTSTTGGSSAPQRTDPGQSGDWISNHWQWVVMLVILVVGIAGIWIGACIWRRRYLRNRELRRQAGGNTDSWGSGMPAAEAGAGIPMTYQDKTQTATALPKFTSTSEKRGATTKLWPFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C545</accession>
    <name>A0A2T4C545_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1391271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C545"/>
    <dbReference type="STRING" id="983965.A0A2T4C545"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="337"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="950" mass="105452" checksum="5EE286A6F3C5BB5D" modified="2018-07-18" version="1">MAHDAPIQRTAPIAIAPKPPRPEPLPLPRRQNSSHRFEIGPASLHGRGSVDSGSFSGAAAPPCHACRFSGTRCTVAEDYDGCMPCQLNGTDCSLVAPSPQTRKRKLNGDSADESVKRGSPGIANLRNNNSSLSSTAASSSFLEDMANVGGPTMLKRTLGLQEDRYSQYIGPTTDFEPSLINLSPFDTHDESLLARGTLRKVSDSDTFLMLPDQNTPGYDHVVEDLDAIEAIVAPNGRKLVDLYFRVVHPGMPIIQKTVFIEKYERSYREFSPPILAAVYILAINWWDHHEELSKLPRPDVRALEKLVRSTLEDAMYRPKLSTVQAGLLLSQRPEGDQWAPTAQLVAIAQELGLHLDCSGWKIPPWEKGLRRRLAWALYMQDKWGALVHGRPSHIFPSNWAVRPLRANDFPDVEWDENDQEERQDIEKGRLVFTRFVQLSEILSVILDTFYTLQAMQTVSNAGSGGTQLVLSLAKPIQLRLKDWYSGLPTNIRLDSYSASRMSSRLSCIGYLHLGYFATEITLHRRIIRSLASNSSSVDSYVQHICRSAAKARLISAMDFVNRLMPNHIQSFWYFASKTNFALIGTFGSLLWATAPGREEAEWYRRRLGEYRWTLSVSSKPGQSKGLTEFAMTMLDISTGLLKQLPEKPSLSRNGSMADFSAMSMPSSYSGGVNILGSFSNLPSTDVSGVQSPRSESESSDEGMEDDDYATPIGLGIGTTPSALVSHGVETTVVEIDPAVYEFAQKYFQLRENHAPVIDDAVKYTNKAANETKEVYDYIVHDVFTGGVEPVALFTYEFLDNLYTLLKPDGVIAINYAGDLMLPTSKTIVRTILKTFPTCRLFRENPPDKRVVAETGADFTNVVIFCRKAKGDLTFRNPVPGDYLGSPSRQSFLTPQHEVSPGELFALGKDEEGSILFRNGTDKASEGQLANAIGHWAVMRTALPARFWENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C561</accession>
    <name>A0A2T4C561_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_300866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C561"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="13245" checksum="A088BA0AF4E53792" modified="2018-07-18" version="1">MAPAAAAHLACFYLAQFTSLRKSPPESYRHMKGRARNAEEYGEDNSPDASYLVFDTHFFASLRNVQELSPLLHALNRGYARSTQAEHHSEGHGSQHQDQLPLATPWLLTPSTRSTNCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5S0</accession>
    <name>A0A2T4C5S0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_306795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5S0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="17158" checksum="CDACDBFEFF07E033" modified="2018-07-18" version="1">MQGEVCSVCLKVAESQLSAIWRLEVGIMHNLISLIPDQAQRSANKALQSFIKETCNLWISLGSLKPTLEKLIAEASTVGPKRETVAYIKVTVWAFLLQKLRSKLLLLLLNKYTNALGLQLLPLFPSAYRHHTLDNNLSVSVRMQSQIVAESYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6A0</accession>
    <name>A0A2T4C6A0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1401440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6A0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6A0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="548"/>
            <end position="549"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="616" mass="67783" checksum="33177E4ECE203BFD" modified="2018-07-18" version="1">MSTHKEGTEYDIIFAGGGTAACIVAGRLAKADPSLSILLIEHGKNNLNDPNVVNSSRYLYHLAPNTQTAIIYKGNKTDDLNGREPIVTAGGILGGGSSINFAMYTRASGVDYDSWNTEGWDAKSMLHFAKKLETYHLDDPAVDQSVHGHDGPIHVSFGAYSAKDAQDDILAGAAAVGIPEIIDLQDFKAVHGFSRWLRYNSPDGKRQDTAHRYVHPLMASGKYPNLHLLVQSTVSRVIFEGNRAVGVEYLPNAAFQPITNLTHRDPSIIKAKKLVVVSAGALGTPQILERSGVGNPELLKKLDIPVVADVPGVGEEYQDHNLIFYSYKTSLKPDQTLDDMYRGNLDFYEAVEKKNPIVTWNAVDLAAKLRPTDDEVAQLDQEFQDHWNRDFKDQPTRPLMLLAVVSSFLGDHKTLPEEQTGPSQYLSIGMYTGYPYSRGDIHITSKDVDAAPCFNAGFLSKSVDLTKQIWAYKKQREIFRRTNVMTSELPIGSPKFREGSKAALRKQPEAQGGFKTLEERKALPPIEYDEEDDKAIEEYIRSNIETTWHSLGTCKMAPKEKGGVVDKHLNVYGTVGLKICDLSIAPENVGANTNNTALIVGEKGADIIAKELGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Y3</accession>
    <name>A0A2T4C6Y3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1455118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Y3"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Y3"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="381" mass="40904" checksum="86FF77995AA4F5A9" modified="2018-07-18" version="1">MAPDAAALESLESLVQTACALLKQLQDVLSSIRNNPDAPPSSTTAEPSSSTAPLDALALARDSATLIRAHATKVSLLIINEPFTPSVVSSVLRELVSGPIPGLVASVQACDPSGYTLVFRNELAWRCQRVLAELADLLQRIPKDGKVLKKEKEGFGGAAGGKGSIASTGVLWAACDKVVALANGGVGGFFADKMGDTPAAPNKPNSTHNSAGPGALVNVEEEAAAGVVADPDRIRPRLESSLRRLRLVILLYQAITKRRMKKLPPFPPPSQTTSNNNNNNNNSNNNNNNNNNNNNDPIAAEGAKVPRRLDELSALLQKLPDRFGDLACAFYDLRPREIDEAMDQCFLDAFAVSELLGEGWDGQRDEFTEWTEKFQKEIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C797</accession>
    <name>A0A2T4C797_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">M440DRAFT_1330057</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19 21">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 26">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C797"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000015">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 21" id="KW-0408">Iron</keyword>
    <keyword evidence="14 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="23">
        <location>
            <begin position="1523"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1237"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PTB77441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2220" mass="253455" checksum="C65C46CA03B7639C" modified="2018-07-18" version="1">MPNTSLRRPTKGYKRGGKTAYHGVKTRTFAASSRAEGTSADEKWERTRLAQSIDERMGFARYESGKKKEGWLVNVQPTSVEDERIPGGRAALDCYFIELDGSTFKATVEYDPYFIIAVKKGRESEVEEWVKRVPGGGVVKAIRRIEKEDLSMPNHLMGYRRTFIELRFANVNDLMAARRDILPIAEKNKKNMNAMDAYAEVATNNGDFDLFDNDLRDDERNTGTSISEASDFIVDIREYDVPYHVRVMIDLDIRVGKWYFVEAKHGVTKVTVNEGRSLPADPVVMAYDIETSKLPLKFPDAATDQIMMISYMIDGQGFLITNREIISEDIGDFDYTPKPEYPGPFMIFNEPDEKSVIERFFLHIKEARPTVIATYNGDFFDWPFVEARASVNGIDMYQEIGWKKDSEDQYKCSYSVHMDCFHWVNRDSYLPQGSRGLKAVTVAKLGYDPDELDPELMTPYAAERPQTLAEYSVSDAVATYYLYMKYVHPFIFSLCTILPLGGDDVLRKGTGTLCEMLLMVQAYQQEIVLPNKHITPKEAFWDGHLLDSETYVGGHVESIEAGVFRSDIPVNFAVDPGAVDELLRDLDNALKFVITVEEKKSLDDVTNYDEVKQQIMSKLLNLKETPNRNERPLIYHLDVASMYPNIMTTNRLQPDSMISESDCAACDFNRPGKTCDRRLPWAWRGEYIPAKRDEYNMIRHALENEKFPGKTPKAPPRTFQQLSADEQANLVRKRLQLYSQKVYHKIHDSTTIIREAIICQRENPFYINTVRDFRDRRYDYKGKAKVWKGKTDALKASGAPSGEIEDAKKMSIVYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGVTCLTGATIIQLARQLVERLGRPLELDTDGIWCMLPATFPENFSFKLKNGKKMNISYPCVMLNHLVHDKFTNHQYQTLVDPKTFRYETHSDNSIFFEVDGPYKAMILPTSKEEDKNLKKRYAVFNDDGSLAELKGFEVKRRGELKLIKIFQQQIFKFFLEGEDLTQCYTAVAKVANQWLDVLHNKGSTLADEELMELISENRSMSKTLEEYGSQKSTSITTARRLADFLGEQMVKDKGLNCKFIICSRPRNAPVTERAVPVAIFSAEETVKRAYLKKWLKEEPADTDPRALLDWDYYLERLGSVIQKLITIPAALQKVRNPVPRVPHPDWLQRRINIKDDKMKQKKLTDLFSSKEPLADITNINGPRAEDMEDFGSKLLKPKQLGALIASSQVQAAPQKRKSPEPAEEPAPVAALPSAMPDPSDDYVGFLQYQKKKWKLQKQARIRRRQLFGERRGNVSSNIQQTFMKQAHLTFMNTWQLLHLKATDTPGIVTAHVLIDAKIHTLKINVPRQVFLNLKKEELPDIEIAGCEVEQVNYTLPNGHESKHLFKLTVPEDVYFNEAEKFSLLFNHPSVEGVYEKQVPLNIRAVLRLGNLCTIDEEQEAVLGKGLEQGFDLMGLKRPAKPKTYLESSPLAYIYISHITAGDRQIFGLFSTTSDQAYVVILQKGRDSGSDLPNITRLYSELLAKRAEEAAGTNWQDCFRYQEKITFKVTQVTTRRKAHLEVADVVRKLRKDEPRPQMMVIQSSQRNLLVHDIPILGEFPVLPLKYDASDSSLPPLGWQAVVARRLVGHYLGLGSWILHLTALARYGDVPLCNLERDDPRFLIDIAYARRLQANGVVLWWSPDPRPDHAGYEKDDITGSLDTVKMPSINNPGTFSSVCIDLDVRNLAINTILTSSLINELEGAESISFNPTADGSEILASENGFANAGVLVLREMVKAWWAEACKGSTMADVLVQHLVRWVENPDSFMYDRALHYYVQMMSRKAFQQLMADFRRVGSQVIFASANRLILQTTKAEVGNAFAYSQYIIKSIKSKSLFHFIDLEIKEYWDYLVWYDEFNYGGKACQQVADSEEQNLETIMHWQMATFLPLRLQPIFQDWVIEFIQLMHKLKRPENNDPDSTPRLTQLPNRNQELDGETQIILGKAFEKPLKKVIVGLINQQKRELLHPELAEDYSFPSLPGSHLQLRNPILELVKSIMQVLSLDKNITLEARLLRKELLALFEIREFSKEGTFTNPSESLKLLQVSCDSCTMARDLDFCRDEDLIGAPGDNNNNSGWQCGFCGSEFDRVGLEERLLAMVEGWATEWAVQDLKCERCGALRVNDFMEHCTCSGGWKAVLSREEVVRKLGVMRRVARYYGLKMLGNVVEGLYEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7A7</accession>
    <name>A0A2T4C7A7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_361234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7A7"/>
    <dbReference type="STRING" id="983965.A0A2T4C7A7"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="470" mass="52298" checksum="2DAB6EA6F979957C" modified="2018-07-18" version="1">MPAAVGSSGEAANSGRLLLLSNRLPITIKRSDDGSYSFSMSSGGLVTGLSGLSKTTSFQWYGWPGLEVPENEIEGMKKRLKDEYGAHPVFIDDELADRHYNGFANSILWPLFHYHPGEITFDESAWAAYQEVNRLFAKTVIKDVQDGDLIWVHDYHLMLLPQMLREEIGNTKKNVKIGFFLHTPFPSSEIYRILPVREALLTGLLDCDLIGFHTYDYARHFLSSCSRILDTPTTPNGVDWNGRFVTVGAFPIGIDPEKFVEGLQRPKVQERIATLKRKFEGVKLIVGVDRLDYIKGVPQKLHALEVFLTEHPEWIGKIVLVQVAVPSRQDVEEYQNLRAVVNELVGRINGKFGTIEFMPIHFLHQSVSFEELTALYAVSDVCLVSSTRDGMNLYTSAWWGASFVAEMTRLTAENTQPKTLRNIAGAVVGGVGQKVKQVAQDATELVTGGEQQQQQEQESAAPAEAPGASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7N0</accession>
    <name>A0A2T4C7N0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1430110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7N0"/>
    <dbReference type="STRING" id="983965.A0A2T4C7N0"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="63810" checksum="51EB2DF0E8D63878" modified="2018-07-18" version="1">MASSTATPSLSSLPPTPSTPSGKAVAATGTAGGGSSTSSTGPDPILRNALRYTISPREYAALHKYILSKSRALRRAAPSPGSVEKALQPRKGRDDYNAKAVRHALRVFTATWIGMKAWDAIMRRLGNKESSGSGKKKPFYKSSALRLSLSLSTILFLYRVLFRFLTRLRAHLLDPQAAPFRLRNPRTAATLTSPFAPAIGASLAGLALGVLPSKQMRVSVAIYALFRALEFGWNVCEKDGLIWGVRNGKNRERPWWFGSWMLQPFAFGQLFHAAVFDPDCFPSTFGELIFKNSSTYLPPRPENYPTNLKWPSPSQILENIAEMARLNWPAFTSPILFPNKEVLPPTLTGISPLSSQAHPLITSLSCATLHPSDPSCLRTYLTFWLNSFPSMTRFFLILYSALTIVPRFRNLYNFPFATIQRIISQALRLSTFATGALSTAWASLCFFQQYLPRHVLAALRVFLGGFLAGMWAWVERRHGRSVFLYTARASVDSLWKVGVKRRWWKAMRGGDVWVFVLALMVTGVVYERDAKAIREGQWRKGVSWLRGEGWKDWAVEDDGEDGDGEEREKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7S4</accession>
    <name>A0A2T4C7S4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1400578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7S4"/>
    <dbReference type="OrthoDB" id="5103320at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015593678" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="47701" checksum="3AC20EF3685E5DA7" modified="2018-07-18" version="1">MRLPVALVLGALLGAAQASVVVRQDNAGPDSSTAPAATAGADDSSTSAPPPQTTTPPPPSSTSSSSSSSSSSSPADSDTTVFETETVTGAGGKTVTSTKTLTATSATTVVVTATVFVTTTVTSSGGETATRVVFDTTTVFATPTDSPPAQKRAGEIAPRTAIDAVPTGAPDADYLAQSLALRDLEARAIFTEVVTVTVGGGGGSTVVESTTRTVKNTATSRTTITSTVTTTDQVGAKTTITSTSLLTVTSTVVTTGVEETTTLPPQSSGSGTGVPDNNGSHASDSSGLSTGAKAGIGVGVGVGGLLILGALLFLILRRRNRGPRPEHDDLVGASEVPVGGAGGGGGAGINGGTSGSQPPMSAHTPSAAAFLAPGRAPVAREGYRGTALGDGRAGYAKPEPYGSAYTSPSPTTTMAQTVSPVSFDRANLLSSHHPDAAAELPNDNPNAAKWHDPNAAEIDGHAVMSHQSGPVYEMPTQTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7T7</accession>
    <name>A0A2T4C7T7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1353893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7T7"/>
    <dbReference type="STRING" id="983965.A0A2T4C7T7"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="4">
        <location>
            <begin position="181"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="341" mass="39094" checksum="6AE512D6DB7D9B2A" modified="2018-07-18" version="1">MGYEEYESYERPSERSRWTPLTRMLLSGEMTQEKQQELTAREKFDRWMINEGYRRVFVFVFILAHALIFAFACVHYGVKDSLATSRSTFGFTFVVARAAALVLHVDVGIILLPVCRTLISLLRQTPLNGVIQFDKNITFHITTAWSIVFFSWVHTIAHWNNFAQVAIKNKLGVYGWLLANFASGPGWTGYVMLIALMGGTEELPALLQKTRLRKVYFFWICRDFGSFEWFRSLLLAVEAQDVDNRIEIHTYLTAKIKADDATNIMINDANADKDAITGLRSPTNFGRPNWDMIFRGIRKLHTPCEAGVFFCGPKGLGSSLHVYCNKYTDPDFSFVWGKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Y9</accession>
    <name>A0A2T4C7Y9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_286698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Y9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="149" mass="17079" checksum="6228E5AD24A48786" modified="2018-07-18" version="1">MSNAGQWYHPRLVIKTNISTLLLNTTRIKTRSLVSLLLLSLSSRFLVFIFHFFACQIGDFASVSDSLRFKAKRTYQKGTRPREEKGEIGTRVVEDESGSCYFLKGQKKNKEHEPNQKGQKTGWPTINNQMMRTHWPLSGGGWQRMKGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C890</accession>
    <name>A0A2T4C890_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1331065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C890"/>
    <dbReference type="STRING" id="983965.A0A2T4C890"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="779"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1152" mass="130481" checksum="281041FD5724B9F1" modified="2018-07-18" version="1">MFSTFTGNSRRPRNVNLSGQASNPFSNTSWSPSAVSNATKTVSDAQAEREKRQAERRRLKAASQIQRTWRGYRSRAALRDRHRHDFDLVYGSRPDLNVAQRLHASFPLLLSFFSADRADDLQRLLLFVNDCNSTSLQQLFDASRHPSRLRKLMGVFVKALGVLVLKDDASLEIRHLLALINHLTATSPSTILKSIDEYYTALARLCQLKHGEEWVQILLESLPAPLGAGEGSERDAYRAFALRFLAAENLQLFEKNIELVAQTINTEKLAMVILEAYNGKPDSLPEKDRLFWLLAHYIDLSRAQKRSTQNLVHFTATFTQLSALSSDISIRISTQPSSDQRDDATTDSLVFPSSSYVSVQLLRLIDSNGISNLLHDFSMSLAQSSGRELEGSELLAGYILALLQSFPSKADDTRMRLFLEEIPTAEGNTPIVKFLWQMMTRTSVFQKLRTESERPAKILHRYFYGASSQQSVHAEEQEWRIILLFLELYTFILRISDDEDFLSGIYPQVLSSDAPQSRTRSCSLALKDVEALITFLKNTSFTLHYSVQEITQTRAAVDASTQARLDLYWGDPSKNPGEPKDTNQSSISRVSTKLDLESLRAIITSALKMLYERDSRKHFLPADHWLMTSKLEKEDFIGAVIAEEERQVQEQADGSDAEADEDAEASYADGFGMHSSFAAQRLSRNVRLERIKANQIRAQRERRLAEMGPKLELLKHIPFVVPFETRVMIFRQFIYLDRLRRGGNHGMMMPPMGRHHAKIRRGQLFDDAFEQFYQLGDGLKDPIQITFVDQFGTPEAGIDGGGVTKEFLTSVTAEAFGNEHGGFSMFTRSRKELLYPNPTAMDVLRESLRKQGLVETDPEWREAISDLLRRYEFLGRIVGKCMYEGILVDLAFAGFFLLKWPSPSRKEENSYKGSVNDLQDMDEELYNGLLRLKNYPGDVSELGLDFTVTDQISAPGEPVKIVTRKLVPNGDEIPVTNDNRLLYISYAARHRLVVQPAPQTNAFLRGLREIIRPSWLSMFNQSELQRLVGGDSMAIDVEDLRRNTVYSGLYAIGDDGEEHETIKMFWNVMRGFTDAQRRDVLKYVTSTPRAPLLGFSQLNPKFAIRDGSSDQERLPSTSTCVNLLKLPVYKSEETLRKKLLYAISSGAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8J9</accession>
    <name>A0A2T4C8J9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1226134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8J9"/>
    <dbReference type="STRING" id="983965.A0A2T4C8J9"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="125"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="336"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="790" mass="88055" checksum="D1A563E5DF9B6876" modified="2018-07-18" version="1">MYLNKKNLKEHPTTHLSYDEGLHLIRSFLEYASHHTVEEIQAFTAQWVPHPQWVKLESVTIPDEHLGRAAELIEGELGPDGIRQIGGRKWWHWRGPKGPMEAEWIEMRADANERKKNNEPLRRVMLYVHGGAYYFGSVDEHRYQMQRHARKLKARVFAPRYRLAPQFPFPCGLQDCLAAYLYLLTIQDASTIVFAGDSAGGGMVTAMLCLLRDQGIPLPAGGILISPWCDLTHSFPSLAGDAPLDYIPTSGFHHKPSRAWPPPNDDDMKMLNEEVEKRRKGIKKPVPPPTSELKEKQQKPVAPLSDEDTGVHIDSTGLHTETEKFLTVTIDGELITMKDQIQMYTTNALLSHPLVSPVKQPTLGGLPPLLITVGGGELLRDEQIYLAHKCANPTKYAPPDADLTDHGKELLAKYKPTYVQLQVWDDLCHVAPTLSFTSPAKYMYRSIAQFGAWALARAQNRDIEIMDDDAISVITSSGSDTEARGQEEQGQQKDEEPAEEPTPTEVGRAGDPLPKFKNYMIRQRITRNGLIFPLSPEEELPGCIMKPEEIGVIKQGPVKKWLNTKHTWDTKYASAKAKVHKKIVKEMLVGYQDFGADEHPPPTALAGRIPVGKELQPRKRRKSFGLAIWSLWGSKHDEMTVEREQKANYEPEMQAVTPELHNGESSNTEGGERPGHNRKASHQRIVRNEHQTSNEDVNEDTPVAQLIAMRREQEAAHDGPSPETGVAGKRPFLDGIALPFTIKNDAETASMITLNSAMTPGSRPMSWGAVSGVGGTEVKADAGQGEKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Q7</accession>
    <name>A0A2T4C8Q7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1391153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Q7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="18566" checksum="FBC077FFB638322C" modified="2018-07-18" version="1">MAREPRLDVASLPAVLPATPWNRASSVLELDKLITYMHGIVCGSIAPESCVCIRGAVSSYLSTCPAGTTCPEAQPSTGEGCRGHAMRWRTLQGSNGRCGVLYLVLPLMYTVYPEEISRGAEFRIALDKATSAPAVMAEDEDEEKEIMKQYATDSMCINPDTVICDRNEGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8V9</accession>
    <name>A0A2T4C8V9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1391172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8V9"/>
    <dbReference type="STRING" id="983965.A0A2T4C8V9"/>
    <dbReference type="OrthoDB" id="4896824at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="760" mass="82067" checksum="D559F6D7ED14352B" modified="2018-07-18" version="1">MSLFLPLWAFLFLVWVLTKLAIALWPTVFAYLSLVAAFAPDKDLAVAVVSWLSLLRYWKPWASATADLRREVDLAIDYTFLAWFLMGSPFVVLTIWAGLKEVLRLVANAIVRRIHVAMEFEFDLTDYVVKCYSPMDPGSMGDRVYRRLFPDFDYYRDEYLKYHPRESQITWPTRPVPRSTVPRVMTPRTPAVESVTDNRRTREWARQKLADIRAGKTAAAQPNDQNTTPFDTEPVPQSREAAAPAVQSSAWPTAPESDPVADVATTASISTETEEPADLKESKGEGQIGAGPKAPEPEASLEVEGNGLLEGAEDSKAQEPETSHGEDGESLAEEPKSSAEEAGEGPLCMDSLEAQEPDFDIKKEGDGFVAEELETSKEEEGEGPAEEPETSSEEEGEGPAQEPKTSPEEEGESSLSVHDPANDPEASLEVEGEAMSSAKVPQAAQEPEASSGVEGDGMLMVIDSAQTEEPEVSSEAEGEGSTKNEASPEVEFDVEMADVDTVVPRPVSPAGNSSSLVHILPLEVVAPWSPAGQAPGFHDETRGYADMLPYLESEYASMDPALLDREIDNILADTDEMEPSFVNDDDFEAYASFLSSVPDDVVVSFPGADAYDDDEVMEDAAFARPSPLDLSDDGSVTSQESPISDFFGLGILRDSGLDEEMASLDLNGAAADPEVEFLTAALARLTLTSHVGDDITMEQQLPQNDPLRTLAGAGAGADGGADADDETPASVTIASPAVMKAIRDSEARRGVQRLGNADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C910</accession>
    <name>A0A2T4C910_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1420209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C910"/>
    <dbReference type="STRING" id="983965.A0A2T4C910"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="837"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="5">
        <location>
            <begin position="37"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="963"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="976"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="986" mass="106666" checksum="7FC7091D294892A3" modified="2018-07-18" version="1">METDSDVEPGGPIANRGPAVLAVTIATLVLASVFVFARMISRYFIVKRFTWDDRTILLAWLISFFLSFTICLGVANGLGKHDQDIPASHIATLRHCEYVFSILYNPALMATKTSILIFYLRLARNTQMLLRFASWLILVIVNIAGIVLTFMNIFQCTPVQAAWNADYQGPTKCIPLLTEFICAAPVNIVTDLAILALPIPVLTGMRLPSRQKTILVFTFTLGVFVAVVDVVRVYYLQQAITDVPTGITTDPSSRFGGQADFAYNASLALMWSAVEVNVGTTCACIPTLKPLVLRLLPSMLNNPKNNNGSRPSPSITSDKSQNQRGSDNRSAGNNMNNSGVVKPEPVAHGALGSGRQLASPGPDAPMSAMEFLTTPDMTSLPLTYSVNRSRTTNTLSTDHSYENGVYFGFVNMTKPKSMLRANSRESWKYCTIVAILFFLWGISYGLLNTLNNAIAAVDNMSTAQTIGLTSAYFGGGYFFGPLLVGEWILRRDEHSRSKRHRQNDENIGGYKATFITGLCIYGTGTIIFWPSAVTNSFGGFMLSNFVVGFGLSVLEVAANSFMVLCGPQQYGETRLMLAQAVQGVGSVLSGLLAQKVFFTSLSHATTGDESSSTTLINVQWTYLGITLLCVVLALFFYYMPLPEVSDSELEESTKLLPVDPTKKSIGGLQLRTVSLILAVMAQYLYVAGQESNSTFFNSLLLSVLPSQPKSGTGAASGAAVTGLSGLGAADPDQPPGLALSLSDYLTVGHTAFAVSRFAAAYLTYLSAKNPRLPQPRTVLSFCSFLCFLSALLCVVIRPSNADLLFIPACLFFFAEGPIWPLIFAIGMRGQGRRTKRAAAFITMGASGPAFFPFVMYGIIIHGGTVQQAYILIVAMQVVMMALPLFLTHVKDARLMVDPRPPRRVPRSEGERPMDEAVSGGVLVDEEPRGNPTTVATDFFRENAVAEKPPRGFLGAVSKGLSAKLNGSRRKSSPALEVEHSEGSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C993</accession>
    <name>A0A2T4C993_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1461367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C993"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="179" mass="19149" checksum="980E143FABE50919" modified="2018-07-18" version="1">MHQDVRRGRGIMPWGWTEGRPIDASNPGCLWQASQGSMRHEGLLQLTPFADHIRINRRIAATRRVIISGLMIAKVAAAVAVPLQPASQIYIHLDITRPVLADPICKQCFRTRGSKGTPAGSLVALGNSTLLGTAAPADLILQVSLSARRGLLVGAGLIKLIVVILRASSPVSKNGRVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9J8</accession>
    <name>A0A2T4C9J8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_64839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9J8"/>
    <dbReference type="STRING" id="983965.A0A2T4C9J8"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008183">
        <property type="entry name" value="PRK10933.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="19"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="574" mass="66311" checksum="EA66D4F50F504637" modified="2018-07-18" version="1">MGSTTQQLQTWWKESSVYQIYPASFQDTTGSGTGDLKGIISRVDYLKDLGADIVWLSPIFESPQKDMGYDVSDYKKIDPIYGDISDVDTLKDKLHERGMKLVLDLVVNHTSDQHPWFKESRKSKDNPFRDWYIWRPPKYDAQGNRQPPNNWESHFQGSAWEYDPHTDEYYLRLFCREQPDLNWENPAVREAVHDVMRFWLDRGIDGFRMDVINFISKDQRFPDSDEAVLRGHEYYACGPRCHEYLAELGAILKEYDAFNVGEMPCVQDENELIKAVGADRGELNMIFHFEHMDLDYGPKGKFSPGTYNLAKLKTVVNKWQKFMYENNGWNALYLENHDQPRVISRFLYDDPQHREASAKLIALFHVFQAGTPFIYQGQEIGMTNVPKEWPIEEYKDVDCLNHWDLYKDTADEETKKLLKAEYQKKSRDNARTPMQWDASPHAGFTTASATPWMRVNDNYKAVNAASQTGDPRSVYHTYRRVLQTRKEHKDLFVYGSFELVDEPNDKVFAYRRRAADGSAAALIACNFSPEEVEWEVPAGDVPKEVLLSTRDRTLGEVSGGKMSLAGLEATAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9L9</accession>
    <name>A0A2T4C9L9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1461430</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9L9"/>
    <dbReference type="STRING" id="983965.A0A2T4C9L9"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015368684" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="336"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB78224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="502" mass="54555" checksum="31B186D3B4C2DB40" modified="2018-07-18" version="1">MQQKRLTAALVAALAAVVSAESDVKSLTKDTFNDFINSNDLVLAEFFAPWCGHCKALAPEYEEAATTLKDKSIKLAKVDCVEEADLCKEHGVEGYPTLKVFRGLDKVAPYTGPRKADGITSYMVKQSLPAVSALTKDTLEDFKTADKVVLVAYIAADDKASNETFTALANELRDTYLFGGVNDAAVAEAEGVKFPSIVLYKSFDEGKNVFSEKFDVDAIRSFAQVAATPLVGEVGPETYAGYMSAGIPLAYIFAETAEERADLAKALKPVAEKYKGKINFATIDAKNFGSHAGNINLKTDKFPAFAIHDIEKNLKFPFDQSKEITEKDIAAFVDGFSSGKIEPSIKSEAIPETQEGPVTVVVAHSYKDIVLDDKKDVLIEFYAPWCGHCKALAPKYDELASLYAKSDFKDKVVIAKVDATANDVPDEIQGFPTIKLYPAGDKKNPVTYSGARTVEDFIEFIKENGKYKAGVEIPAEPTDEAEASESKASEEAKASEEAHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9R7</accession>
    <name>A0A2T4C9R7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1328230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9R7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9R7"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF14">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="547"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="611"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="664"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="730"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="780" mass="82177" checksum="08AD3368B336088B" modified="2018-07-18" version="1">MSGPRESAFLPTIKCSSCGMQVEISMMGEHACPGPGPAVELSPPPDSNAKFQDPPPRSAEHKMYMAPGPLTPVSAGGSRSVSPATPSRPSFADQARDFFSFGAAKADEPTQAPNKLDINGHRSSKSVAAVPSTPASTKPLGFMERMNTIAPGPFDASQRPSTSHGAFPAKKESTSRFDMPMSTEPAFMNERPGTSSSSLSSGSSGVPSTPQQPRRNNYEGFGPPSGRGLDPNGMAPPSRAETFPGPSNGETPRRPSYPSPRSGPLAAAAAPPGERRPSLAPDTSRKPPPRKSLIPQHLPTASLNLAAEFGASNPYHNSTDSASSGYSTFSNQSQGTAQTSPARSEVRNSIPDALRVRSQDKPRPSNLRLDPAAEIAPPARSPVPRSPYLIPEADEERIDPAIQSGLGQQPFKPYRAFSPAMSSTPAPSQEPPELDLGPKNESSPKQPSPRQSTPKQSPARQSSPRQPTPVQSPPRQSQPAPVVSPPRQSPPRQSPPRQSPPRQSQPAPVVSPPRQSPPRQSQPAARESPRKSEDRKGSKDLKLPSRGDCKACGQPITGKSVSSADGRLTGRYHKACFVCATCANPFTSAEFYVLDDKPYCEQHYHKLNGSLCGSCGRGIEGQFLEDESQTKHHLNCFCCQDCRQPLANGYFEVDGKAYCERDALRRTQPPPPAPYPRGPGRGGYGGPGGPGPRPYGPPGRMGPGGPGGPGPRPGYGAPGLPRGPAPYGGPRRGGFGPGMGPGMGPGMGPGMGPGMGPGMMGPGLNPRPKMNKRMTRLGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9U7</accession>
    <name>A0A2T4C9U7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Iron reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1329450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9U7"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015449429" evidence="9">
        <location>
            <begin position="24"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="231"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="477" mass="52857" checksum="B3CD6FDB13E1CF1E" modified="2018-07-18" version="1">MLLRSLWRAALTAAAALTASTRADDANNPTGQSTFISPDKSLAFAFTVPDNGNTDVYFSLRVSTKRSWGAIGLGSDDMPGALFLILYRSKNNRDNVTFSPRLAYGHYEPKYYPDLKFEVLDGTGVKDGYMTFNAVCNEHCRSWPAGGTSKGYVDVSSPNQKAIYALGPKESFSDDEVDAGLKMHSEYGTFTIDMKRTQGRADLPVLTEDSVAEGTTLNSHSTGKFDWKAAAHAAFMVFSFMLLLPFGAILIRTEKLAKFHKFNQTFALGLVLGGFAFGILASFHYQRSRGFHSLHQVLGFIVILLMFVQLAMGILHHLKWRKTQKPTTFGKIHLWNGRVVMTLGAVNGYIGFGFALDRRYALIVLGIVFFLVMCTLGYIVWAAKRQMPRRQQGPTGFEGLNHSYQQQHPEPWRSTGYTATVTAAPSYPHDPPPGYEAPSAQIGLQNVTPWRGATPGRDSYEDEPLNLGSTQKPREFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAQ7</accession>
    <name>A0A2T4CAQ7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1420686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4CAQ7"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="314"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="484"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="728" mass="81202" checksum="94CBC76539F7AF32" modified="2018-07-18" version="1">MPFLVEDSWINSQANTHEIAELEDCSIAVDASYYLSLLLDTEPAHEPLLPALGGLTGIQVHIRQNLDLWDKFGITPFFIFNGQSIVGQDEVTLRRGRAANQKTDEAWGLYSQTEAEQAVAAFGANPGAFLIQNLYPLLQSILKERGLHFLVPPYNACAQLAYFEMINSDQCAGVMGPQELLLYPIQDSVIRNIDFMAGTVTAISKKKVMRVLGVSEPMFVDAMLMTGTSFLAPFPPLQDTAMYPNPFTIMDAVNILRTSEKAVANACASFNDILQAQDPNWLDKYRKARMAAHHFIYISESGEVKVNDFDRLTKDNHEYLGLQMPAELFHYLNTGLIGARILNSITHGQIIVFPTLDGNASDEYKKLVTSQILPIKEQTFGLVIPRVHRGIGHKDITMKVWFDPKYSYTLNHRSAQPPPSQIVGTWDVKEQDLRRFFPADFAGPIYLEVLALAKQDFVEKTICRGKPIRGIDSTDMVVSVAIWRFLHLRGYVDDSHKLTNWGNALATTLLAIRDAMEETVPGIDEAALLAFELLRFGLLSGKYREGAPGMPRKGTDEDKASVILISQCASLLRLRHQVFGYTGPLNKSLLGFRALSTTVREADRDLIEAIVASMFMYGQCQRDRNDQLDISQRLPFSQEPHIGLGIAALTFFDEDDAEDSKEARAARLQTFPSTFVPLSEALPEDLRIAVDFVSALNQGVQTLDVSSLPAKEKAAWTKAQDYINARPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAV9</accession>
    <name>A0A2T4CAV9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1469021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAV9"/>
    <dbReference type="STRING" id="983965.A0A2T4CAV9"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="550" mass="62854" checksum="AA7D2A18273102AF" modified="2018-07-18" version="1">MSSIWRLCRDDQISSSSIPPRNRVSAIRKHWQTHTTRTRDTDKMPKSSSDAPFSFVNYEGPNLNTNAHVRRRIRQQAMRDAAMARRQRGDYGKHNMRQYPVFVQPSDGHPPDDSEDNRDPRDMGDFQPSSLSAPFAFQDPLMPKQFAILLNLMPLTGLRLGVGTLSHYLYEPTQPKDHIITAQASSQRLLSFIPSRYGHVSLLRHATDCVIAKLQYESQPVEHRSPINDVKALSHYQRALKALQQALLDEREWAKPETLCATQLLGIFEALNGNEKENSWMHHVGGAARLVEARGAHMFQSEFEKALFLAHIGPTVMSAFLNNTPCFLEQAQWQAVIREAVSEDTTLTNDKEFALALWGGLIVMPRLFKNTTELLLSPCPPSQIEIDDLTERLSAKRENLIVWLNWIRKKPIAQAGWIREDKYGVLVFSSDFDYKKLGPWCLTRLALRGTYAVCRMIKSRLLYAISPFKFHHLEVEAQDIAHRILNLKEEVAASQDSPLVWSQFMAQGSWIAKGIVETKEAWAEEKDRHQGMLSKCKFEKWNEAIGRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB36</accession>
    <name>A0A2T4CB36_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1437610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB36"/>
    <dbReference type="STRING" id="983965.A0A2T4CB36"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
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        <location>
            <position position="283"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
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            <end position="342"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="423" mass="46921" checksum="14A94002DE43590B" modified="2018-07-18" version="1">MSDPNNPNINIRTTPQWSLYQRESFWNTNDGKFPPFNTDPAEIEKLAKEKLSQGGWYYSSCNAGISWTHLANRQAFYRHRIVPRMLVDTNQRDTATEIFGHRVSAPIGFAPIGINRIYHPTGELSVAKVAQELNLAYSLSSAGSYSIEDVAKANGSGPRFFQLYQSPDDELCLSMLQRAFDNGFDVCMLTTDTWSLGWRHNDVFTGNYAFYHDHGAGDLGLQDPVFQKRLKEAGIDPVKNPKEAGAKWIDENIWHGRAITWDKMKWTMEQWKRISGGRPFCLKGIQSVADAKKAVEMGVDGIVVSNHAGRQVDGGIASLDALEKIVDAVGDKTYVMFDSGVRTAADVAKALAIGAKFVFIGRLWVWGLGIAGEHGVRHVIKSLLAEFDILMEVGGFVKVDDFDRSCIDSLPNSSSLIAEHSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB56</accession>
    <name>A0A2T4CB56_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M440DRAFT_1399923</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
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        </location>
    </feature>
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        <location>
            <begin position="270"/>
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    </feature>
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        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
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        <location>
            <begin position="232"/>
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        </location>
    </feature>
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            <begin position="271"/>
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    </feature>
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            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="40836" checksum="8361EE148BC1853F" modified="2018-07-18" version="1">MAFLEDPRLRQRWNQIAHDAETVTENAAAGIWTFQHHYINPCLGSIRGAIEQCTTRRAETVEQPRRKRGMSYGTRGVRRKNSEQDPTIIPSTQPIGFLSKLPWKMGGTLRYKPSAADLQEHPGARKHEYTESQPLLGAEEDSDHDGLLQPSQSRKRSGTTGSGGTSDSYRSRGDLFPSDGEGEEDAVALDDEVTYDMIRRDDRSSGRGGTTPSSKGKRPAHTVSRTVSRTTLGSVGSGDSLGLAIFGTAPHDASHDAQLLPSLRDLELEEERLGREEDEELAKKKEAAAQLAVERGLQTESEPKPPDGADEGYKPEEAHEIHLDNDEDDGGDDDEEHRHSGLSGGDAETRMKEEGPPAAQSVFVPARLPHFR</sequence>
</entry>
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        </submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="191" mass="18550" checksum="49943D6B56E4CC64" modified="2018-07-18" version="1">MTPKWWWKRYDAGATKRGSGAIGGGRGLKPGAGVVKGSDTAEPGVASDSDKTSGEDPGDGDGDADAGEDAADAGPADLGSGPGSTGGDGGAVAVAGPRGSRLSVVAVRMLLLLVVAMRVRVCLFGACVVLSLAMSVLRLRLSLSLSLALSLLLGLLMPGPGPGPAARPLSLSAPALPLPASAASAGAPPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBD0</accession>
    <name>A0A2T4CBD0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_270581</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="16080" checksum="7E143E120A479C32" modified="2018-07-18" version="1">MYARLSGPPLTINQSNSPLQHPHSPRLHHASRPLAHVRELTPELVPQLLAPMAPHCGGFSGRDRRTVHPKSPKPPNRSPSRPCNPPVRLGDSPLPPWNPAHDGMDVSGNVRKEKVRRPRDRPRYITSRGDIACDVRISRVHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBM1</accession>
    <name>A0A2T4CBM1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1352846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBM1"/>
    <dbReference type="STRING" id="983965.A0A2T4CBM1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="540" mass="59305" checksum="772C1569004E659C" modified="2018-07-18" version="1">MTTTDQLPTGAAGQFDYIIVGGGTAGCVIASRLSSYLPKKSILVIEGGPSDVGDERALILKDRFKMQGTELDYAYTSVEQPNGNSNILHSRAKILGGCSSHNDMVSFRTPEYDAYTWERLGCSGWSFETFKRLYQQLRVITYPGAHPRDQNQLSKDWILSAHRALGLPLVKDFNKGITSSSGLTAGAGWTPLSYNPDNGWRGSASVSYIHPMLRGDEKRANLTILTNAWVSRINLQGDTATSVNVTTSDGQRHTVCAATEIILCAGAIDTPRLMLLSGLGPRGRLEAVNIPVVKDIQGVGENLQDHPCTLVQFELHDEVPENTATHSDVLAFLRHKPYNWAGDDGNIPDILLHMWQLNDDMTPDGYERPDHPFIILPVVLRTHTRGSVYLKSKDPQEKPAIDFKYFEDPDGYDADLLVAGIKAVRKMAASEPLRSWIKHEVAPGAQITSDEELSRYARAASQTMFHPACTTKMGDVLNDPMAVVDPRLRVRGINNLRIADAGVFPTMITVNLMLTVLAVGERAAELIAEDAGWHGSKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCK1</accession>
    <name>A0A2T4CCK1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1327232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCK1"/>
    <dbReference type="STRING" id="983965.A0A2T4CCK1"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="226"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="832" mass="90597" checksum="8F017A97989E6238" modified="2018-07-18" version="1">MENPEKRPKRSRFDQTEPEPKRASRFDRRSRSPPARRSEGRERSPLPKEEPSETKKSPVDAAAAAAAAAAKINAQLQARKAPQHVDVPPIKSASETPADGGDQEMKKEMYVADGDFIQDIEVNDLRNRYLLTKGSTQEMNSGVDSHPADVTTRGSYYPNKSMATAANPPLYLHITSTTKAGLEAAVEKINELIKQELPQLVDERRFRRRDQEPQPPVERDEYGRRKWPEEKIPIDLEPVHGFNLRAQVVGHGGAYVKHIQQETGCRVQIKGRGSGYLEAATNHESDENMFLHVTGPDPNMVAKAKELCEDLIANVKEQYEEFKARPPRYNNDRGGYGDRGGYGDRGGYGDHHHRGSHDRHGGSHHNSYSSYNNRYNSEPRASNSPAPVAAPAATAVDYAAQYAQYYNGVDPYAAYGGYANYVALYQQYYAAQTQAPAQSSHAAAAPGQAAPPPPPPPAEAAPPPPPPPSSAPPPPPPSGPPPPGGSFSAVTITTRIRVDGSGHSEQREMSHQAYPHHDPIKEPHSVSVKVLRLSQPSLVTQYPIDPPFSPPNTKSQPAPASLAYAPSNTNPDPFLLSPILNLPVSFGSAYVGETFSCTLCANNDLPPDAPKRIRDVRIEAEMKTPGLGGTQKLELGPANNHEGGAAADGGGVDLEPGGTLQRIVGFDLKEEGNHVLAVTVSYYEATETSGRTRTFRKLYQFICKASLIVRTKVSGLDANTTNSSTRKWILEAQLENCSEDVMQLEKVVLDVEDGLGYHDCNWASDGNQKPVLHPGEIEQVCFLVHEKGADSAIRMTADGRIIFGVLGIGWRGEMGCRGYLSTGKLGARIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCR9</accession>
    <name>A0A2T4CCR9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor, 25 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1325967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCR9"/>
    <dbReference type="STRING" id="983965.A0A2T4CCR9"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="264" mass="29695" checksum="C2313485BB2FFB03" modified="2018-07-18" version="1">MSTIPASALQSGSPPIIPLPFNAKQPEKVTLYPLSNYTFGVKETQPEEDPSVIARLKRLEEHFNEHGMRRTCEGILVCHEHNHPHILMLQIANAFFKLPGDYLRPEDDEVEGFKARLDERLAPVGRLGEGEEAGDWEVGECLAQFWRPNFETFMYPFIPAHVTRPKECKKFYFIQLPKSKVLSVPKNMKLLAVPLFELYDNTARYGPQLSAIPHLLSRYNFEFVDENGDVVAATPGSGAPDGYVPKAKVLAGDDTDMVEENGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD24</accession>
    <name>A0A2T4CD24_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_2187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD24"/>
    <dbReference type="STRING" id="983965.A0A2T4CD24"/>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28665" checksum="FDDDEFBD566484C9" modified="2018-07-18" version="1">MPHQRRKSGPYTAAASTTDVRKAVTATPAQYKRPAMTRRHTPSAAQKLGRGGRETDTEIWDNDERESFPQYCMICEKEFHTHDELVLYCSDACRRVDQDSSAQAKSVRSYYSSVYVNQRRILTESLAGSEPRDIVPRASPSRPSSMHFSTSPPASPDTALNYHTSAMSALRSLNVRPPSPPSPAGSGIWPFSRSSATSPNNSYTRPSASLLYSHPSTLDLAYGGTYSHEAGSGGMDRPLPSRTPGGSSRPKSVELVIPMLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD52</accession>
    <name>A0A2T4CD52_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1326189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD52"/>
    <dbReference type="STRING" id="983965.A0A2T4CD52"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF4">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="220"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="391" mass="41179" checksum="2C9A791ECDE37872" modified="2018-07-18" version="1" fragment="single">ASAAPASFCPNDGVCFEWGVPEASAKAGSGDIFFQLKAPTSWQWIGLGIGSQMVGSQMFIMYQDGKGNVTLSTRPGANHVMPTYKARSDVELLAGSGVVDGNMVANVRCGNCTNLDLTGKASWISAWKSGDSLDSTNPAAAITQHDGMTQFQVNLAQASISSDANPFDGSKSDSSNDGDGSGSNSGDSSGDDSDGDGDSDGDSAVSGVTDGSSDQTLVSAHGILMSVIFVIMYPLGSSLMPLLGKWYIHASWQTIAFLGMWAGLGLGVTIAKRENEFFGQAHSRLGVILVALISLQPIFGLIHHVNYLKTQRRGIFGHLHCWYGRALMIIGIVNGGLGMQLGNVATRYIIAYSVVAGVTTLFYLASIALGWSRTGRNRRQSKQVESMAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDF6</accession>
    <name>A0A2T4CDF6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1419927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDF6"/>
    <dbReference type="STRING" id="983965.A0A2T4CDF6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="179"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="576" mass="66073" checksum="9EB0D604C3F6C75F" modified="2018-07-18" version="1">MELSQQSIHDVIHPTAAFADESVWEKSAATAAARAARETSWEESPLNPKNRIDSLEPPARPLWRIDGCTAFGTQFYAVPLFMDSMPPFRVDVFIPEPATLSHELRSVLDMDVAFYTRDASRISQLGVTQHVLRLLQYWTSTLGDPRQIYQNMPFGSRIVFNNLPKDVSQVRVSMAPTYYLERQMLSVSSFQSFWGSHVSLPPTVDIHDVVYLSQLHDSVCLIEYEGKTWIFKALTSYTKYLYHELRQLLSIQAHPNIVARPVHLITKKCTFGSKTAVIGFTLELHVHGSLRDLIPFLQVHNQVSLADKAKWSAQLASALVHLRETCHIFYPDLRLDNIVLSGSGDVAMVDFEQRGVWCEFAAPEVNAIEYVRLLAIDDEIPPHVAEKYAGMLTSMLPGWEEMGQGEDYVWPSEGYNVPWACLTPREQEACEVYMLGRVLWCIFESESAPQRAAVWLSYRWEPLVEFPGYTRTPPAMRDLIDRCTRGRQAGLSRLIVRRRDKLVLREFENTGESTAQEVQNVARDWWAKEIAASEAWLQERAEGLKRGDWNENYYNRPSLREVHEELDKFRKENNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDV0</accession>
    <name>A0A2T4CDV0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1399047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDV0"/>
    <dbReference type="STRING" id="983965.A0A2T4CDV0"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="325" mass="35111" checksum="8A7F8DF185B51A06" modified="2018-07-18" version="1">MPTPRDLGQSTKLNCEVAVFSGAAGLEAQDEGAKRIELNAPGSYEEGGLTPPVKELTSIASQLEIAVRIMIRPRGDPRPTLAAAAAASAAAAAAAQPKQGQDQGKELTEEEKQKQKEAEEDALQDFIYTDDEIQLMLQAIADFKATRVLNPIRGDGFVFGVLRRQTKASTLEKYPDFKYTIDEERCRLLIDAAKPYPCVFHRAFDPIAASERWAKGIDILVRCGFDGVLTAGGHGGCHENQDKLDAICHRAHPGSLQLIAGGGVRKGTVGPLVAQLSVHGTKNVWIHTAAISRAADRDRAGLGVEQLNTRELRGIINIMNNTRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEM1</accession>
    <name>A0A2T4CEM1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_175855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEM1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="18509" checksum="9A5F1139977A882D" modified="2018-07-18" version="1">MGRRTLLASKDAQSFQGSTQGCLSDGHVRSTRVRPTGERMGCEWLPLSMRVTQPPCITPPSHRLHAAGIYLGVCLLTADTTVEAGDQDVRHPARVRGQPGGSPALRTTGECLLALTLVESVWKDLWRTPLHLAVELDLGAGFTSLSRKLPQVAPLVLQMVPLGSSLDTIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEQ4</accession>
    <name>A0A2T4CEQ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEQ4"/>
    <dbReference type="STRING" id="983965.A0A2T4CEQ4"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015772407" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="37"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="290" mass="31240" checksum="49BF93D7A2801191" modified="2018-07-18" version="1">MKLFSLIGGLSAYAAALELTAPLFGDLGGVGAGRIPTSFESAVMGRRVLALSKLGTLSTVFPKADSPGDAEAAERRPEGLDGLPIALLEYISDCEDDGNPTLLAIKIATSFKNARAGSNLSLSVEWTPPYPPSKRISFLSRLSAFVPFLGNKEAGEASKLDGPDVSSSSSLPDTAPYSAANLPRFSLIGYLEPIKPNIKEAVRLASCYTTKHPDAKYWLPGNPIHASEWARLVVTQVYWIGGFGDRAYIGWIPVEEWRNVTKEQWQGIQLPGEKKGWSEWSINEAGAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CES9</accession>
    <name>A0A2T4CES9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1110277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CES9"/>
    <dbReference type="STRING" id="983965.A0A2T4CES9"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="403" mass="44931" checksum="DD1C018B735F3D9F" modified="2018-07-18" version="1">MSALPPPPAGINLHDDRRAGIMATSIVTWVLAIIAVGLRILSRRMRHMRLWTDDWLIIAALVPSCAHVFGMGVYAVSRGLGRHVWAGPPDARFAWAIGLFIAELGYFVTITCVKFSILAFYWRAFRVMRSVMIPIYTLALIVACWAIAVILVTIFQCRPTSAWWDRFNPSHPLQPDQYDCTVDSVKFFYGNAIPTIATDVLMLALPLPYIAQLQLPRGQKWGLAGIFLVGIFVTVVSIVRFHYLIKGNLTSPDITWNFVDIALWSVLEGNLAIVCACLPFLRPIFKTLGCRNFSLSTATSKKQKQSGSTPKLSLHPNDHPRTWQGDGRFGTSTCHSRAYSTTRETDGHPFVRLTDNGSEASVPVKERPDEPHIELGNISAGEHLAQSNGIVITREFHLQHQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEX6</accession>
    <name>A0A2T4CEX6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1323913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEX6"/>
    <dbReference type="STRING" id="983965.A0A2T4CEX6"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="502" mass="56858" checksum="0013487B0B2ED353" modified="2018-07-18" version="1">MASDKTTYSQFACIGTGFSGIALGCTIKRWYGITDVRFFEKNSDLGGTWFVNQYPGCACDVPSLLYSFSFAPNPEWSKVLPSNDELWRYLNKVCDQYGLRDKMTFNSTVERCVWMEQTARWRMTVRDKASNTTFTHECQFLFSGSGLLLHPRKADLPGIESFKGPVFHASQWRHDVDLTEKKVVLVGNGCSASQVVPAIKDQVKHVTQFARSKHWIVPDVKVPNTKLFQWLFMHIPGALAFGRFATFLFMENSSRAFYRTKASDAYRRQVTAEAEQFIKENAPEKYHDMLIPDFELGCKRRIFDPGYLASLHSDRVTLRDDPIQEVTPNGIRSKGGFTEADIIVLATGFETNSFCTGIDIVGRGGVTAEEHWKSLGGPGAYNSTNISGFPNFFLLLGPNTATGHTSTVMAIENGVNYSLRLIEPILRRKATAIDVKLDAEKAYTSQIQTALQYTVWLSGCNNWYNRTQDGTVRNAMTYPFSQAYFWYRCLFPVYQDFNYDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFH3</accession>
    <name>A0A2T4CFH3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1122201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFH3"/>
    <dbReference type="STRING" id="983965.A0A2T4CFH3"/>
    <dbReference type="OrthoDB" id="5391043at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="921" mass="102402" checksum="27F87BF7786115E7" modified="2018-07-18" version="1">MEEQAVTTTKAALPDSQGSSSQQNDGGKDEANRKKTSTRKRTKTGCLTCRRRRIKCDEGRPICHNCIKSRRECEGYSQRVIFKEPLGSFSSPFNQAIFPGPPSIVDESLPAHRQSSRGLFPAIAPRPPTFDQRHHVLPLQPSSTPYQQQYHHETLIQGSSAYNMAPSQLSHAPYNPQFPNPLLAAEISGGPAYYTHAPPEAQFFSIQDGGSAGDMLGDFRHLTSNHALTARTGAASTQHDRWGLDMLDDEASLPDSDDDLPDVRGNLLPIKSMVPERWTMSAVDASVFSAFAQNDDVLAHMETPYSSEFWASGLNTIFMHFINVTGPGISIFEGDISCASERARSGTAVGTGQSLWSYAIPSLALQHLGLFHAMLALASLQLAKLRDNPPTAALRHYHRAIRRIAKNVKSPSRRTQPATLAATLLLGYFEVWSSDHTKWCNHLFGARILFREMALGDMTRVCFPAKRMRQRREAGGYQLGHVSSHFYHSHPHTAPAQSGQRSLDYGFLNAITGLAVSPEAYGDGVGQPSDERRSSVSDKEIEKYDIICDLFWWYCKMDVYQSILGGTKLFMEYEHWTQIPPRAPFSTYSSAYGTYDHLILLLGRLSDFVSKDLSRKQKVIEAQGGGAGTGSPPMFPGMFPTFGKVQAPMGFSPPRDSTPHSDSQEDLDPEVSYEAALQEWNAIYHAFEIFKSRLGPEFQPLGDELDGQTRPKTPFGDPIYFRTYSIAGIWMNYYMGFIHLYRSHPSMPPVAMRAAGMTAKKTAGFALKIGQIASGLAADCSEYTEINTYLGSALIESSFCVFVAGIQYNDAAQRQWVIQRMHDVARLTGWQSAMQIACGCESAWIKASQMGGPEYTRPTIINDIPSTIWKNPRRIDKKIDELHSSEERRLVLAKAERTHYAIGILAIETELARLELRDDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGR0</accession>
    <name>A0A2T4CGR0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1398126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGR0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGR0"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="430"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="562"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="738" mass="78909" checksum="6851A38217E0BDCD" modified="2018-07-18" version="1">MAQPQPQQSQVPPRAFSPPQPSPSPAASQQSGFALPPNKRVRTDGPASQPGSPYAASPYAMSPVPVATPPPAAASPAYPQAQPQAQHQPQHQPQHQPQAQHQPQHQPQHQPQHQPQHQPQHQPQHQPQAQAQAQTPPVQAGYHMPYTNGHPPPPQGLSLPAASPTVPAPVMQPSHQTPVQTPIPLPIPMPLPMPVQTPAQVQSPAPVQTPVPLPSPLPMPQYTNATMQPMAQPATPLQTPGIMGPPQKPAERPTRDYEYDVTDSLAGTGIDLRAEEQYMSELYSNAFETIPEARTGFAHYAPGSKSSFYGAGPANQPAQPTDLSQTQYAAQAAEQAWQESAMRLAVQRTQEISDPFLFVALLHRRMEKIAREHHLGLNLELKNNAQSMGKMKLPENFATPKVTVKTSPGPDGTLVETSGSFIPHDAYLVDQLALLSIATKQRLRELVEDANVIAKTRQKTSHGDVPPEWAAAAAPMNAEPLEPMETDVGANGSVAEADAGAEAGGRPGTNPLKRPADTNDTSVKQPPAKLPKIASYVTLTMRDLARQEREWEEARLRRRQLRKEGLGDGAPSASRAGSAAPGTPGSVAPESEKAMTKKELKKTQAMKAAEASSHANQNLTSSMFAGLGGKGSLFGKGKKGKTYDWMNVGRGGSGASTPTRAAPGPGGKGPNGVPGAAASPGNMALTTEGRNRLGTWREDKEKGKNIQLRDWITVLERDGREAKALQHAYIHLDSSNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH13</accession>
    <name>A0A2T4CH13_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1428421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH13"/>
    <dbReference type="STRING" id="983965.A0A2T4CH13"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="160"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="297" mass="32180" checksum="9B40E01FC483B495" modified="2018-07-18" version="1">MSSARGQYHRASLEDDDLIDPDDADLNDFDDPLAPQSSRQPLTNTIASGASASGSLDQGYLTSRIPGDDRRAPQNTIDESVWETLRRDLLAVWDKLKEVLYPRYLLGGTMFDSEGGLRGAYSNIRGAGLTGTREELTGLASRVIDAEALLQSNMSPGLRDWDLWGPLIFCLLLSLLLSFTARADQKDAVFSGVFATIWLGEAIVTLQIKLLGGNISFAQSICIIGYTLFPLVIAALLSALRLHWIARIPVYLVLIAWSLAAGVSILGGSGVVKNRVAIAVYPLLVFYLGLGCLCFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHH1</accession>
    <name>A0A2T4CHH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1003873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHH1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="216" mass="25219" checksum="77597DC8F7B2762B" modified="2018-07-18" version="1">MSAVPRCPPSPPPFNLRELDLAHPPLFVYFDGLTRRWIETPLGVLIELRAPEDCETTTRYWQRKARGVHLTSWWIFLCGFGTACMYMACTLQSTLLIYDYRVRKGRCKRSRGTVRHYRWENARFGNPPCVVVDTNAGFDRFGWSCFCVLIWGAMVSGDRCSFFFFFFFFFFFFGKSTMRGRRVRGLEMTGYTYVVLFCFSVKDAAWGVLGVFVLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHK9</accession>
    <name>A0A2T4CHK9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF92-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1417754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHK9"/>
    <dbReference type="STRING" id="983965.A0A2T4CHK9"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="39653" checksum="9E07AF9E70CE3C0B" modified="2018-07-18" version="1">MKPIIAIPATAALVLRAWKKKSLTPAGLVAATATAIAHAYHPWNLPFVLLVVFFLAGTRVTHVKENVKAKLTVSAKGTSGGEGPRTHVQVFANSLVASVLSILHANQLYARAAALKTPGAAEPNGSLCFSWGGDLFVVGIIANYAAVAADTFSSELGILSKSEPRLITSLTLRKVPRGTNGGVTLLGLGAGLLGSLTIVTASMLFLPMCDETTATKRAGGVPWSADNRRLFMTFLVIWGALGSVLDSILGAIFQRSVKDVRTGKIVEGDGGSRVLVSSETGGSEKRADVKASLRQGEATNEAVDESAEVTDKFDPKNKHRKPSFGDEQPSRIVENGWDLLDNNDVNFLMAVTMSVGGMAVASWYWGVPWQSLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHQ2</accession>
    <name>A0A2T4CHQ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1396265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHQ2"/>
    <dbReference type="STRING" id="983965.A0A2T4CHQ2"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="501" mass="55283" checksum="A57806F952DC567A" modified="2018-07-18" version="1">MVGVPRSSGCQLCRQRRVKCDEARPECGNCRKYGVRCPGYERAIKFVSGKHAVRSKGSRASRTGRQGSASRGTASETLWSAGTASPDGDSSSSSSKEIASRTAAVVMPLVASPQPSRALFVGTLMDMAQTNLASKDVSTFLSFFGQLRFEALGTSAALDGAICSLSLHLMGKELGDDNLVARSRTVYGGSLVALQAALRHPVKWKASETFCSAVLLCFFELFAGTTSPDTWLHHAQGIATLMEQRGPAAHAQGNDAAILFSFRGILIMSSLFFPKSDKCFLALPEWRRVLTGTARSIYSPAAPDLTRPVVNSFLLCLADMPEVMWWGYPIREALRAGRQVKPERIRHLAQLTAANHERFAVWYEDFKKLGVMPKEVPSEDRSSPYPIVLEHPVGWLGTMLMGYWASMLILQELLILCRWPVVDFDDSQPQLVRNILRSVETMGRGIMGPFRLGYSIRIVYEFANAETQRWIIAMLDRFSKRYAATDKGGYPSPRVDAQGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHY6</accession>
    <name>A0A2T4CHY6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1323159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHY6"/>
    <dbReference type="STRING" id="983965.A0A2T4CHY6"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="696" mass="77927" checksum="2B7B4F179D24468B" modified="2018-07-18" version="1">MPEIASSPTPVGSFIFSSVALLLVSLAVLLILRHYLPLRTTPAFYIVPIFFALWLPSVLVLLVPIDLASSAITDDVASRGIWLPQRVVLVLWRITYWLTFCLTWFILPILAEYSDTGYREPHDKLMYSLRANAQFYAMILGAGVVGLVYIFISYEFSFTALKALLMALSYCWGLILAIYLMGHGLVSIPRHLLRSGSISGRLRSLQIKAPRVYEKMEDSLTAVEEVEQQVSELSRRKTGTAAAFQDWIEELQEMANVPESQPRSSLLDPTAPRQAVPHVITEKYLADLTRKLVRARHSRSQYVGEWTRLVHEAAKLQMILDSVASKKLDFGEVSPHAGFWERVKILTPYSRYLCYYYVFPYMRMGFGALLGFASACIVWSEIVKFPFPKLSIIRVSVVHHWVGDKAQVGFAGQVIAALWICYMCAAALSSMTEIKAWRGRALVKRNTGHEAAFWFASQVAKLSVPLSYNFLTFLSKEVYEKTIFYHFLGQYVDVTPLGKWFDNFFPIALVIPILATLFGLYGRIKRIFTGVDILDDEEDNPTGYGTGSWREGRDLIARELGGSTPRRSALANAASGRTAPILSIPAIQDSSTRPSRSPLRSPISNTRRAGQAPPRFTDEVPEDDNIFTIIGHRMKNTVDSFETPQWFQEIGQGIKKPKWMGGGDAQPANAAGGSSGNNNGPDIRRWFGGGDSHIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI93</accession>
    <name>A0A2T4CI93_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_79871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI93"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="144" mass="16158" checksum="5E99FC9CBA44D378" modified="2018-07-18" version="1">MHLSFRCHPYDCSFEVRRSRDSLESLETRICKVFMPFFYCYSDSVSRFCIDGLVIASSGKKEQPSPLTLEGLPALRGDRQYRDTEDMIDVAPLRMRCHASSPRSVISVLPSREARLHVHGIVNSHRGALKQTVTTVGLVSSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJA7</accession>
    <name>A0A2T4CJA7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cora-like magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1321561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJA7"/>
    <dbReference type="STRING" id="983965.A0A2T4CJA7"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="591" mass="66343" checksum="FCC61598097E4E5A" modified="2018-07-18" version="1">MALVEESGSSAASPTEARPSLNRVRYDLSVDTENANNAPPQADVRRLSRSDTTVHREPFSPLRRRKSARVQTFHTIDDNDDFDFDATHTERPGWQPGSEPGFDPHLPDGGHASMPTLSADCQITVVDFSKDRMDKKHFDNDSFVSFLTEPKEEWAKCRWINVNGLSWDVIQAIGAHKGLHKLALEDIMNIRNRTKADWYPSHAFIVMTLQKLVHLVDDDDSSSDSSSILSTKSSSKIRSWFRNFGNKAADKAANTTTPFDPEKRAPTKCMTELSETLGLQETSMMRSLQRYHASGNEVRTEYMEANSILTPLNLAVSAEQVSIFLTSDNTVISFFEVSAGDVERPIVTRLSTPGTVLRESCDASLLVQAIIDAIVDLAVPLTAAYNDVLGDLELDVLTSPNIKQCKTLYICISEINKMLRFLNPIDNLVNVLRDHRTNLTHDQAMTELENPASGVIVTPMTHTYLGDVLDHCIIITEALQQSKQSSENLINLIFNTISAYQNESMKQLTTVTIIFLPLTFITGFFGQNFPPEGFPEINNGIWYFWACAVPTAVATVLILMREMIYGWIVRLIQRQRVLSIRKKNKAKRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJC1</accession>
    <name>A0A2T4CJC1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1021072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJC1"/>
    <dbReference type="STRING" id="983965.A0A2T4CJC1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="119" mass="13227" checksum="8A6DD77965E29A01" modified="2018-07-18" version="1">MSGLHDILSPLTLAWGNLGIEHPVDLAARAGKLEGLWDDDYDPYTDFVGASGDTMGISTLFFMAKYPSETLSAMEAFYKDKGVKIWQLRSLLIKDAAREIEWSSHFGAAEAQLLRFLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJF7</accession>
    <name>A0A2T4CJF7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1459808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJF7"/>
    <dbReference type="STRING" id="983965.A0A2T4CJF7"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="171"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="356" mass="40050" checksum="AFC22BABA878B1CF" modified="2018-07-18" version="1">MAVPTLDLSKFLSGTPEERKQFALDLLDSFERTGFAKLKNHTFSNDQLRELFHWGHSFFNQPLEAKNAIPNEPGPRPMRGYTPWRVEEVGKLHHEEKVRIMKDSKEHFDQGPSDDAEYPNKWPTDSSLSGFRPFMEAFYQQCNDVCLTLMHALEVAWDIDDGSLVARCAPSATDMRLTHYPEIAVDELQTGRTTRIAPHTDFGPITLLFQDSTGGLEIEDRSADKFVPLPPTDTTEMILNVGDTLTRWTNGRITGGVHQVAVPEAMRGKSGLIIPSRMSMAYLFKAGRDTSVGPLPKFISDKEPAIYPDITALEFQRWRNSIVYNLDKKEDSVKYNGHADKPATAAGLQQVQAIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJK8</accession>
    <name>A0A2T4CJK8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1305558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJK8"/>
    <dbReference type="STRING" id="983965.A0A2T4CJK8"/>
    <dbReference type="OrthoDB" id="4899548at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16637" checksum="47950F0D26A6E00A" modified="2018-07-18" version="1" fragment="single">SPLSLAAERGEAERVESLPKEPDADLNAVNDGGNTPLSRAARNGHIEIVKMMLQDKDRIDSEHYYHAFFAAAKGGHSDVLDLLLETFGLDVNAKNRRGRTPLSWAAQSGRIEEVELLLEHGADANLKDSEGKTPLWWAMMEGWVEVMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK18</accession>
    <name>A0A2T4CK18_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1388237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK18"/>
    <dbReference type="STRING" id="983965.A0A2T4CK18"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="561" mass="64344" checksum="67756C0575D0E89E" modified="2018-07-18" version="1">MGDFPSESKKFNTELTDYSVQHDERTGPYAEDLDIDAVIVGAGFAGIFMLKTLRDRGLKTYIFEAGNDTGGTWRWNCYPGAGVDSEVPEYEFSWPEVWKTWNWPNNYPNYENLRSYFDHVDKVIGVKKDCAFNTVVVGAHFDQAEGKWNIRTEDGRTTKAKYLVLGTGFRYIPDWPGMTKFKGVIHHSSFWPDEKIDVRGKKCAVIGTGASGVQIVQAWGPEAGELKVFQRTPNLAVPMRRRDLTVEEQEKAKKHYPELFRYREANFAGFLYDWDEKNTFDVGPEEREEFYERIWKDGGFRYWVALYKDNFYNPESNKESYKFWAKKTRARINDARKRDLLAPLDMPHYFGIKRPCLEYNYYEQFNRPSVDVVDIKNNAIKDIDETGILLEDGTHYDFDVIAVATGFDIVTGVMTQLGLESVSNTKLEEEWVTGAVTYLGLTVSGYPNMFHIYGPQAPTLLSNGPTTVELQGRWIADCIQKMRMNNIKYINPKREAAVAWKNDIVNINNQMLFPTVRSTYMGGSIPGKVYEPVCYPGGIPKYAKLIRNALDEMTGFDIVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP00</accession>
    <name>A0A2T4BP00_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1426900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679251">
        <property type="protein sequence ID" value="PTB71045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP00"/>
    <dbReference type="STRING" id="983965.A0A2T4BP00"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="277" mass="30123" checksum="72B480A9843D95BC" modified="2018-07-18" version="1" fragment="single">MDYSASIHETEDPAASPWGNTPGSSPQHDRTTFASLTGDAPVPAFPYTPQPSNGDDVFPQSGSITPTAGAEGGDFGDAGAAASSEAETVSQTAESEAAQSTASTEAPSEEPQQPRKPPQPQFRLQAKITGLERTGKKDPILRFDVHTNLPRFRTTQYRDVRRLHSEFVKLGEHLISANPEALVPAVPPPITSAGAGTEEDENRVKALMQRWFNYVCSNEVLMRDDEMVLFVESDFGYSPLVKRKQPATGVRRKILKQFAPPPDDTPELAEARPIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP45</accession>
    <name>A0A2T4BP45_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP45"/>
    <dbReference type="STRING" id="983965.A0A2T4BP45"/>
    <dbReference type="OrthoDB" id="5337545at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="286" mass="30924" checksum="086BFDC26209955A" modified="2018-07-18" version="1">MDRKPEGNGPDEAASSSPFSPNRKSSPLNPMDSKGKQKAWPESAASRLEASAKLVVNAITSSREMPALVSESKSSSGSRSLPSLSGIAGEASSPSSHQQTPFEQRRMAANECHNDMFDSFVENHAGVLAIDGHYEGVSETSFAIQEASDGLAVVDLLCQPGDEFPSALSGQAHDLRALEDDDPWLEAAIGSADDPEDQLDFTPDFLTRPELSAEAELYLGTEDTQETSRTWLGYWSEVFATYNARVWGNSHPPSSGSHPQEEPGSSEPTTMNRALSRLKQILFHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPI3</accession>
    <name>A0A2T4BPI3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1344645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPI3"/>
    <dbReference type="STRING" id="983965.A0A2T4BPI3"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="70"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="343" mass="38077" checksum="5E104E3242FE10D2" modified="2018-07-18" version="1">MSPRYSTFSRTALARTIPLIRQSWALSLRATPLGKTFGSTTTRLASSGNQWKQRQGHDAYVRYAKVQNLKSRAAFKLVEASLALDILIDSKYKLFKKGQTVVDLGYAPGSWSQVAVDRTRPYGRVIGIDLIPAHPPQGVATFQGDFLSPTVQKLVKDFIAQSHSDRPRPAVEKDDVDDGEDLLSEHTIIDQPSYIDRERHSADIGSTSTKSDSKQSVDVVLSDMSEPWDQESGFRSATLSNPYDRLMNTSGNRSRDHAGSMDLCEAALQFASDTLKPGGHFVCKFYTGAEDKELEKKLKLLFSKVYREKPEASRAESKEAYFVALFRKAKATVDSTATDSHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPN4</accession>
    <name>A0A2T4BPN4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_219387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPN4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="123" mass="13385" checksum="0310F4920D8D2F20" modified="2018-07-18" version="1">MHCSVFIDPGSVHSSFDQVLWPSTTKSTFFHDSMTLKHTQSSTMPPVHRPSPAPEEPLGQALSLQGGRIPRPTASDSVVQVQLVFPYSSHYFDGLPRIIPASHLAFSNVMGAQSSSGWGRGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPP4</accession>
    <name>A0A2T4BPP4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="11">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1473611</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="11"/>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPP4"/>
    <dbReference type="STRING" id="983965.A0A2T4BPP4"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000027">
        <property type="entry name" value="Probable exopolygalacturonase X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF14">
        <property type="entry name" value="EXOPOLYGALACTURONASE X-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015537052" description="galacturonan 1,4-alpha-galacturonidase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB71271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="437" mass="47728" checksum="7142F765009A0197" modified="2018-07-18" version="1">MTFLSSLAAAVALLALLNPVDAHKALVERPNLQWGPKTPGHVFPHSPKRRKTCHVPSCGSDDAPEILKAFRRCNEGGTVVLNEEYTIASPLDLTFLQAVDVALTGTIKFTNDIDFWVKNSFKYNFQNSSAFWRFGGKDVNIYGGGQGLIDGNGQAWYDRFAVEPTLLRPILLVLDGLERGSVTGLKMRNSPDWFNLIANSSDILVSDIDIAVRSASKNPAKNGDGWDTFRSQSIVIQDSLVNNSDDCVSFKPNSTNIIVQGLQCNGSHGISVGSLGQYPAEYDIVEDVYVYNISMTNASDGARIKVWPGTDTPFEPGLSGGGGAGYVKNVTYDTFYNDNNDWAIEINQCYGQSNQTICNEYPSNMTISNVVFKNIWGTTSKKYDPEVGTLICSSREKCVNIAAHNISVVNPSGKAPQWICTNMDESLLDINCVSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPT7</accession>
    <name>A0A2T4BPT7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1466391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPT7"/>
    <dbReference type="STRING" id="983965.A0A2T4BPT7"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="42"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="380" mass="42973" checksum="3806DE7BCA6ECD06" modified="2018-07-18" version="1">MFGKIALEECWTIPEELANNDPGKFVAAGTGSRLTNELLDIHGSRLKQMDENDVDFMILSFNSPGCQGIADKAQAEAQATLANNRMEAEVMKAPHRFAGFAALSMHDPAQAAAELRRCMTKLKGFVGVLLNDYQSCGEDGNGMLYYDQPEYDVFWQAANDLEAPVYMHPRPSNKLIHRLMWDGRPWLDFSALGYADRLNMHILGIVTNGILDRFPKVKLVFGHMGEHIPYDIYRIDHKLDRSRFPNMPMRKDKLVRDYFGEQLFITTSGHFSTPALMCAMGEVGVQSIMFSIDYPFESIPNACAWWDEHVSASVNQHDYTNMGRNNVLRVIPRLTEEPHNLRTMTPRECGVGGLAAKQGEVCYGLYNKSWNKREIKIVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPX8</accession>
    <name>A0A2T4BPX8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1473553</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPX8"/>
    <dbReference type="STRING" id="983965.A0A2T4BPX8"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000045">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="835"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="440"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB71373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="862" mass="94102" checksum="385186B6A8799040" modified="2018-07-18" version="1">MVASRNTSLAASLLLAAANILIPLSILLFATGFFPYKPFLPGLAEFEPLEYGSPPKAPFDRLVFMVVDALRSDFVYSDGSGFEYTQRLIRDGGAIPFTANARSPTVTMPRIKAITTGSIPSFVDLILNFDEADTSSTLAAQDTWLSQLKAKDTGKLLMYGDDTWLKLFPDTFDRHDGTSSFFVADFTEVDNNVTRHIHHELEKDDWSLMVLHYLGLDHIGHKSGPRSTHMPAKQREMDGIVHQLYEALETKSHLQSTLLVLCGDHGMNDAGNHGASSPGETSPALVFLAPKLKDISSRYAAPERPKNEYDYYSTVEQSDIAPTLAALLGFPISKNNLGAFIPEFLSFWPSSSDKVQILIRNARQILNVVTAAFGSELFDAQAAVDPCASMATDVDELACEWRRISLDAASQADAAAVDQAWLSATSAWIRKAQELMSSMASNYDLSRLALGQGLAVAAVVASLAVLGLQGFQQVGFPLPLFLLAVSYGPMMFASSYVEEEHHFWYWASTLWLAYLGIRDVAKSSRLSSVTSHVLSLAALRLTRSWNQTGQKFAGEPDTVKMFLTPNPELLWVLITLTYVVVTFQTLQSLSGMPYVLATSLVPAIFLATFTFKLAFTAEDAPELVVGFARILLDTFQGPALLLRARIVFGLLAALMGFAAYRAKTGGPRAAQSSETVELSHHLCTLLAMTQSRATNIPLFLLSSIMLQALQSANLSVAEITTSSILLQYATFFAFGGSNAISSVDLSSAYNGISGFNVVAVGILTLVSNWAGPIFWTSATNLLLLQNQQRRGTTRAFRSHVVLLTVFASTSVAFVMAACTALRTHLFIWTVFSPKYLYAMAWSLGQHLLINVAFGGFLFWIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ98</accession>
    <name>A0A2T4BQ98_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">M440DRAFT_1344071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ98"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ98"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="867" mass="93783" checksum="834FC7ACF1604748" modified="2018-07-18" version="1">MASPNAFLSSPSRSANRKSHFFRSSSPDLPAIGDILSRRARNQPPERDDPALVISSDEESGFTRARPTRYAEASPRPIKSVPNGVEDTEADDPSMFIVDPPTIPAIRTPEPRRHYAAAAQFRSQSSSPAKDQPWKRFKSTAHSSQSDSNDSKPAYIKEVEPLPAQQTTDEPPPAAVDGSLRVENDINAPLRLDPAMVRRLDWTPPSHKFTTILKPSSPALEGLQSPGEPRGDDRNFEQLLESYKCPNDLQQNARTPADEDASIFRKRKLVELVMTSAAPAEVPPEADNMGPPKRKAKAPKKRPRTITELATSAYRVPEPEESAPSAADEDTTTKEPDATTAKGGNKGKPRKRTSKASAAKKKKPAPPPPPVLLPPTEALQEVARQDFVFGTSSQLAVEASPTFLRDLHAAMRRSNQAEYIDLDAPVNSDGIEPPERKRLWAAGARDADGDLFDVELSKIMERSSPPLPAIAEEDPFGYTGVDRQTTLPAASVNGADTGLHREPLPGHADATPSKATEATDFIIAEDTMQLGSDISMGSPIPRRMKPVVGSPSVKPQGSNSETKPTETQAPKPSFELYTDARLSKEIASYGFKAVKSRQAKIALLEQCWQGKNNPVSPVARRTVTTSTAAGGTASQTEVKTPRGRPRKNSESSPEAQEPPPSAQPPVSPSRPRGRPKKAATAAASAAASTTRKRTTAKTPRAKMTPSKTAAEASTARKCKAPAAKVVVEIPDSASESDGSLSPHPSPSLECASSPLPVDLSLSVMDDTDPSLALNSTQDQPLSHEYITKAVTSAPRTTDPANPSWHEKMLLYDPIVLEDFTTWLNCGQLTRVGFDGEVSAMEVKQWCESKSVCCLWKVNLRGKERKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQA7</accession>
    <name>A0A2T4BQA7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_62206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQA7"/>
    <dbReference type="STRING" id="983965.A0A2T4BQA7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="323" mass="35244" checksum="7D7E1957D371B6EF" modified="2018-07-18" version="1">MGAQWSQFFPPKPTFTEADVDNQEGKVFIVTGGASGIGLELSRILYLKNARVYIATRSEEKARQAIADIQASGSSSGSLEFLHLDLADLTSIKASAEEFKAKESKLHVLWNNAGVSQPPAGSVSKQGIELQLATNCLGPFAFTQLLLPLLRSTAADEATPKGSVRVVWLSSQVMELSAPPDGIILDEIRTPTKDRNRNYTNSKTGNYFLATELARREGPSSIVSVSLNPGAINSNLLRHTPHLKYLAYPLLHKPRMGALSELYAGLSTDIGLENNGCYVIPWGRISHNVREDLIKASKPTDEGGSGRAQEFWEICAEKTRDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQI2</accession>
    <name>A0A2T4BQI2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF887-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1434334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQI2"/>
    <dbReference type="STRING" id="983965.A0A2T4BQI2"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="69"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="327" mass="37590" checksum="9F40410460A8C09F" modified="2018-07-18" version="1">MKDPFFVPPIPWLSELVQPWCDRLNLPSLPLHIHEVLLSALFYTVIFWPISPMLSRLLAPQHYNKLSRKRRLNWDAHVVSFIQSTLINVIAIWVMVVDQERKNMDWEERVWGYTGAAGMVQALAAGYFVWDLFVTSFNLDVFGLGTLAHAIAALLVYTLGFRPLVNYYGCVFILWELSTPFLNIHWFFDKVNMTGSRAQLYNGILLLFSFFSCRLIYGTFQSFSVMRDMWAAVNARPTKVSIAQSPVMEFATQESTVQAWLAISYVMSNLTLNSLNFYWFIMMIRAVLKRFKPNEKLAITEAEVDLSSIASGVSLGSEPQRRKQDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQN0</accession>
    <name>A0A2T4BQN0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1466210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQN0"/>
    <dbReference type="STRING" id="983965.A0A2T4BQN0"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="417"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="743"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="711"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="854" mass="95325" checksum="5406B96F7F3F28A1" modified="2018-07-18" version="1">MDSTGAPRPRPRPAHTQGTTRCAYTKDGSRLVTVGSNNTIRLYKTGSDGEPINIDDCQEQNVAVAAAQDFFVVGSEDGTVSLYSLATANFDRFLVRTSLPVRDVALSGDAQWCAVASDELTVKVVNTHDIKQLRHLNEHGRAARSVSLDPNGRIAALSCVDGIIYIYSLTAEQPELIHKVDGVIGAGEADSEASVKAVWHPDGRAFAVPTPTRDIQVISKNDWEKQRAFTNGHSADITALAWSPNGVMLASACKGGKVLVWETSTQNVIQRYEYSNVIDLAWHPSKNILSFTTTEGEVYIYPDFLSDQFSPMLKLPVQPAPFIHDPLLEISANRRAAVANGAKRDIPARPRRDSLGSLDSYLQDENYADGDDDGFVVDDDGAGYTIGQKRGYVGDDFVGGGEYSNKRRHLMEPQYHEAFQPGSTPWRGNRKYLCLNLIGFVWTVDQDGHHTVTVEFYDHEFQRDFHFTDTFLYDKACLNERGTLFSCPPKDDQPATIFYRPHETWTQRTDWRTQLPKGEAVTAMSLSESFITVVTSANYVRIFTLFGIPYRVYRPKSAPMVTCASWRDYVLTIGNGPVTADGNTRLLYTIENVKRDEICQNEDTVALPEGATLKSAFFSDNGDPCIYDSTGTLLTLLHWRQPSRASWVPLLDTKLLPRLASGRKSETYFPIAVAENKFHCIILKGGDQYPYFPRPLLSEFDFSIPLHSLPEPKTKKNRVDGEDAIMDDDDDDDEEEEGAETKKLEQQFLLKGVQAAQLRDLVDATSGSHAQRSLLSRIELEIDKTLLQLLAVECREGEERGMRALEMVELMRDRTGRMMEAAYKVAERYGRTILGEKIREVGESRVSGGDGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQU2</accession>
    <name>A0A2T4BQU2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1385956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQU2"/>
    <dbReference type="STRING" id="983965.A0A2T4BQU2"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="228" mass="26064" checksum="1AA3AFB3F75F29FD" modified="2018-07-18" version="1">MFSVRTAPLTLRQCSKYCVSPSFARRTFAQAVKMSSISEAIKKDHRELEQYYNEVINNQGDHDHQERYGNQFVWELARHSVGEELVVYPAFEKYLGSKGKEMAESDRKDHHVVKELLKSFQNMKPSDPDYVTKLKELWAPLSEHIKEEEERDLPTLEQKLQEVEGESASMAKSFGRTKAFVPSRSHPSAGEHPPFETAMGLLAAPIDHIADLFRKFPDNTISPNPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRT7</accession>
    <name>A0A2T4BRT7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPR1/FUN34/YaaH-class plasma membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1364093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRT7"/>
    <dbReference type="STRING" id="983965.A0A2T4BRT7"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29507" checksum="8E702E3662B43914" modified="2018-07-18" version="1">MADEKGTHAIDSDSDRAEALNRFRSATSIAMTPELFEKLYLSPQSKVKGHLRDTFGNPTPIALVGFLMALTPLSCSLMGWRGASGGGAATIPVYFFQAGILMTLGGLLEWILGNSFPAVVFCTFGTFWLSYGGVLNPSFAAFSSYAVSGDDAAEGLETIGFNASLGFWFLFMGLLSLIFLVCSLRTNVAFFIIFLTLTIAFGLLTGAYWAMAEDFTGNAHYAHKLLVGAGASAFVTCLAGWYILLAISLAIVDFPIQIPVGDLSNVIKGRSIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRV0</accession>
    <name>A0A2T4BRV0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1343032</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB72015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRV0"/>
    <dbReference type="STRING" id="983965.A0A2T4BRV0"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="658"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB72015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1036" mass="117031" checksum="6AE2DB7332A8945F" modified="2018-07-18" version="1">MWRNSLLRGVQAARLATRPTRLAALPRPLTLTTRRLYAATTTTSNATASAPDPSDNFLSGSTANYIDEMYMQWKQDPKSVHVSWQVYFKNIESGDMPISQAFQPPPNLVPGMTGGVPRLAGGLTLDDGSDVTNHLKVQLLVRAYQARGHHKADIDPLGIRNTSAGFGNIKPKELSLEHYGFTEKDLDTQYTLGPGILPRFKREGRDKMTLREIIAACEKIYSGSYGVEFIHIPDREKCDWLRERLEVPQPFKYSIDEKRRVLDRLIWSSSFESFLATKYPNDKRFGLEGCETLVPGMKALIDRSVDYGVKDIVIGMPHRGRLNVLSNVVRKPNESIFSEFAGSLNAGDEGSGDVKYHLGMNFERPTPSGKRVQLSLVANPSHLEAEDPVVLGKTRAIQHYNNDEKDHKTAMSVLLHGDAAFAAQGVVYECLGFHSLPAFSTGGTVHLVVNNQIGFTTDPRFARSTAYCTDIAKAIDAPVFHVNADDVEAVNFVCQLAADWRAEFQHDVVIDLICYRKHGHNETDQPSFTQPLMYKRIQEKVPQIDIYVDKLLKEGTFTKEDIEEHKQWVWGMLEESFSKSKDYQPTSKEWTTSAWNGFKSPKELATEVLPHNDTSVDRASLNHIGEVIGSAPEGFHIHRNLKRILNNRTKSVTEGKNIDFPTAEALAFGTLATEGYHVRVSGQDVERGTFSQRHAVFHDQETEETYTPLQHVSKDQGKFVISNSSLSEFGALGFEYGYSLSSPNALVMWEAQFGDFANNAQCIIDQFIASGEAKWMQRTGLVMSLPHGYDGQGPEHSSGRLERYLQLCNEDPRVFPSEDKLPRQHQDCNMQIAYMTTPANLFHVLRRQMHRQFRKPLVIFFSKSLLRHPLARSNIEEFTGPDAGFKWIIPDPEHQTGNIKSPEEIDRVILCTGQVWASLHKYRADNKIDNVAFTRIEQLNPFPWQQLKENLDMYPNAKTIVWAQEEPLNAGAWSFTQPRIETLLNQTQYHDRKHVMYAGRNPSASVATGLKTMHMKEEQELLEMAFTVTQDKLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRZ6</accession>
    <name>A0A2T4BRZ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1098649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRZ6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="77" mass="8212" checksum="E64AF7444F503C09" modified="2018-07-18" version="1">MYVHLGGLGGSKVPRPSPAPAPPAPPESVPPPQLQMTKTPTTKFTTQHINSNGQLLLRQHGLGLLDRQLVPRLASLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS20</accession>
    <name>A0A2T4BS20_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1385187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BS20"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="876"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1758"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="893"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1780" mass="196902" checksum="20C563A9A6D21CB4" modified="2018-07-18" version="1">MSSHAWLDSLTEDWVSERGSSPAPLPLVKSTKKSLLSLPPKHPPSRIPRWRHPGVVAPPPQDKSMTILEGDRSSEDNKSPKRRLLKFAKDRKSSQKGNGGRSLSSTTGSVVVHKNARQRTPAARGRSETPEWKRRLVHGKLGYGEQRDLFSSAAVGLQDMFKPPPSSEADIDSPSPNLNSPSPNLDPPGQNYSTNTFDPDQELNADEEDGDCSPNQVTPSPSPRRPPREMKYKLNVEDDQNDHSDASILNSQEPEEEEGQEEDRQNEGAGTQEGSYLDIPSLVEGISRKASGQSYTRNEDFSPILIGKRSDEDGKVEFTPLEMPTEELRERLERLQLNQMILDPSHNASDNAGDTKPPKTDSGDDSSIKYHFDTSYGSNDSPEGSLQHRSLSPDLGEDWSEMLPEDSMQASTPKQFPTLRTQDADSNARDSFLDSPNVPHAPFPSPDKRQIRETSTQSNTSPLKLFGPYDTFTNQTLLRRISQFEESLSGMNSRGDHSPSTPSRDPSKKRVDRTSGANRYVSHFGAGELEGYEFTNDLSHSPAEHSSLLFKEKTTPLHPPLAAKGPLKLVPPSSWLHDDVSLHVHRSRRKSSSQTPSVDAGAEEYDSMSSSPANSVSSQDEAYDESWAAKRDYGSEGKRPRASPSKHPTPKRRRTLHRSDIAFDIEGRKSLVPKLPRPGSNLRRRSQAERSDSIDLKDAERLSRRQSHSSAHTSKSVQDDVSQGRARRSPTRSSIHEEDEPDSPGTTGERKPSIRTQDFVDQAAQIMAMIRNQVSQPGLSSLEESELEAGVASQNATMEESDGSTAEPFSRPPSRDGKPIPRQARQQEDPELVKRLKKYQEMSDMGDVVSSSMRSVSLAKDAIRAAKEVERMVDRASRIRTSGGNGGVGGSNYDSASETTSPVHDLFSSTSARSTSHLFPTSSSRGSESRKVIAPESVSHLIPDKIGGMYLDKQNNIWIRNKDSKASVASHNSGSDDSEEDPFANIPDLSVDMTEEMQHMKQTPRGREDMASSKGKSSRHSSAQTHSLKSYTTLAAYEPLDPEVAARARGEIEKLDAQPGESSKSADDGGSRLPVLKAKTSSDGLSSKRRNITISFTSPIASIILGVLPEDIEGLEDDPVPGESSESPPLHAAQFSGAKVSTPDPLRTIRATSMSSGKFTPRPVSRIDEQDEESTVELPNQSRNRSQHQQTPAQKDRHLSFIGDNTMMSLKSLEGGSGFGFLMSTPAHAAINLKADDSLMIGRNVGKLSLSPLSEFSMNNHDKSFGLEVSYVMGQRRMATGDGSKKVMSMTLRTLVEKLSEAQPHEPYWEDMTSLTLQDKQLTSLHGLNKLCSRITTLDVSKNSLGHLEGTPEGVRQLKVSNNMLTELTSWDHLIHLQYLDISNNQVKSLSALKRLIHLRSLRADNNLLTSLDGLDSHDGLLSLRARNNLIEELDFSNIEWGRLTELDVASNKISSVKGLHLLPALSHLDISDNHLETLVFEKVNKTLRKLDISDNDIEDLDIRHLGSLQTLHADRNRISHISGFRYVRRMDSLSLREQRGDAPLDLSFLISACEIRKLFLSGNYLGSFQLQADFLNLQLLELANCGLEVLPDECGQLMPNLRTLNLNFNAIRDLSSLRFIPRLKKLLAAGNRLSDTVAVTELLTDFPHLTELDLRDNPITQGFYPPVQMLISPDKMGSADSFVMPDADMERDETFAKRLDETTRLRRRLHEVVYVASCKRLRRLDGLAIVREKTLAKDVLLQRLIDDGLVPELEDTLVGESESAQQHHGAAPSPYLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS74</accession>
    <name>A0A2T4BS74_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1405898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS74"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="481" mass="53148" checksum="D45D4ED311478EA5" modified="2018-07-18" version="1">MASNANASNTMDGAPHHNQQQQHQQQRSKPVGKPRGMRRDRDCRSCKLRDVKCDLNRPSCGECIAAGVPCGGYPQRVIWVGSTSSAKDASPTASTTPSRAQRQARGHQSMLSPSSDSSLTPDRPPDRPPDSSLSPPERLVSSPRDEPINWAEADQNSFIRPLVSLCQQIISLDGDALSSNRYLSFEALRLISRLRDFVQARIDGHPARAPSDAWESETMARYRLDALMSLKDTLKATNPFAFIGIAAFAFFEVCDSGFGDWQRHLYGAKSLLDFHCKSREELDTLSKSVTGLGEMVVRLVWFDTCGSIIRGTTDLIFEPWHRELLTESFFRTVGCASDTFRLFTRVASGEVASNPSTSVILAMEQLLKLGQGSSDWDRSADAYRCAGVIAVLTRVSGEQSKDSTISLAVDRTCQIIAATPSSSQFYIHMAVPAYLAGINASSMKQCDVIRAYWHNCNHAGVRRYPDGLARCEDRWRMKGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSI3</accession>
    <name>A0A2T4BSI3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1441978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSI3"/>
    <dbReference type="OrthoDB" id="504210at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26857" checksum="BD62CE6E57E59D82" modified="2018-07-18" version="1">MDQTGIIERRLPNAVIYNLTQPNKVTITLPPKSTWSSGLHWHESHTEYLKLLKGSIKVRLGDVEQIITASKTNQPEITVERYTWHEWQRAELDGEEVIVEERTDPEDGEKALFFWNLNGVILDAGRVVGTNVPGFALFPSKIKDLIMDIWITLNLFIVFHSLDNFPVVLSKTRFWKGKASRGLSADWFVSHLLLSLAALAGRVLGLRAVRSEYTPAPQYNRWKEHHYIDKSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BST0</accession>
    <name>A0A2T4BST0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1364012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BST0"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="241"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB72363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="430" mass="46195" checksum="83FC42B7E61C9B91" modified="2018-07-18" version="1">MDSKDQSSEATTELRPEPPIPDRKPGESQSFPDGGLRAWLVVLGAFFGLFVSFGWTNCVGVFQEYYETHQLASYSPSTVSWIPAVSMFTIFLAGPFVGQLFDHFGPQILLLLGTIVHVFGLMMASISSTYYQLMLSQSICSPIGAAMILYPSFSCITTWFRKKRALAMGIAASGSSLGGVVMPIMVNQLVPAIGFGWTMRACAFLMLGLLIINNLTVRSLLRPQPKNFGIAAFFTTFKDPPFLLLALAAFFYSMGMFIPITFMVTYGRSRGMSTELSGYLVPMFNAASGIGRILPGYMADKVGNYNVSFCAALLSTLLVFGVWLPGHSHATAIVFAAMFGLSTGTYTAVSPALVAQISDIREIGLRSGAMYATMSVAALTGSPIGGALITAAGGGYWKLQVFTGIMIAVGTAFYGAARLYLAKGRLWAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT21</accession>
    <name>A0A2T4BT21_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1465564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT21"/>
    <dbReference type="STRING" id="983965.A0A2T4BT21"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="758" mass="84653" checksum="BF94878D9C79C885" modified="2018-07-18" version="1">MTEQPPRPKQAACLVCRRSKIKCDWMPYEAKCRRCIHLNCECIRPEFHPGRQKGIKNKRVGLDKALYQLQQAVKRVKSGEARGAEERSIVASLRQLLDDVEGNEDAAEHSSRQGSRSNTQEEEGGSTSSDLDEDNENENDSAGNRSMADFVQRTEESLAIDDAENPLQLLARASYFHPGDRRSGNSPQSQRQRDAASSKQDPESTRVQQFFSQAKVKLDVGEDLDPVDLGLVTMDEAESLFNYFYSKLVHTRWGLSPRVHTATYTRSRSAFLFTTVMAASTLFMPSAGPLSKRLFNHVKMLAHKVTNDKYKSVEIVLAFMTHIPWIFPGDHTMDDETCMYIAMATTIAFDLSLHKVLMPMDVLESSTTVSKGECLDPRTALAIDGFPDVDPWSEQGQLLLRARERCYISLFVVERGMALARGRPFMIPITRNIKDCDTWHRSPIADEQDGPVASMAVMRRNLDGLFNTVRALCDGSQNSNSDGSLVARSIQGAIERFFDQWLAEWGMMIGLGPGTLSIDWIKERHLLTAITERRLPPYVDILVAHTRLSTYGRIINHPTAPVEVRIFFRTAGLSAALNVMRAAIQGESQLQSMPNNTAIMISFAACFALNISAYAPDGSGLAPSIRRLIEEAIGVLERIGTVTPHRNGLSVLYGKHLRHLLRISGPSKGGRQPKAQRTTPSSSEPMQDTPPALPSSFMDQQMLWPDMVQFSTMSDDQIAQVLNQPGNVFEPSSSFGGNMSWEEMNNFDWLNWPAFNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT30</accession>
    <name>A0A2T4BT30_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1341720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT30"/>
    <dbReference type="STRING" id="983965.A0A2T4BT30"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="141"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="421" mass="47928" checksum="56A180FA1D47B3B1" modified="2018-07-18" version="1">MAVDKIAEGSDINLPTLGVAMGLKQTSAKGSTYPADAHPSGKRAHGRAVQVLRGLALGVYFFTCCVTIFVSQVLGCWLYFVNRDIYYDYMSMTKRWFAVTTTFVTQVWGPTTIRISGDESVAGEILPAEDGGVQFKFPERLVMIANHQIYTDWLYLWWVGYVNKPAAHGHIYIILKQSLQYIPIIGWGMKFYGFIFMSRKMATDQPRMAYRLGKLKQTKTDPSGKQYRVPMWLLLFPEGTNISGNGRRKSAAWAEKNGWKDPEHVLLPRSTGSFFCLNELKGTVDYVYDCTVAYEGVERGKYGENIFTLSSTYFQGRSPKSVNFYWRKFKLSDIPLDDAGKFDVWLREEWYKKDALMEQYLTTGRFPAMPGSKVDFIETKVRTKSPLEVLQVFTIIGITGLVWRNVQRFGGVVANRFGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT79</accession>
    <name>A0A2T4BT79_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1363519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT79"/>
    <dbReference type="STRING" id="983965.A0A2T4BT79"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF3">
        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="63898" checksum="1F256D729B27D917" modified="2018-07-18" version="1">MAYIIAVNASILSQTGGTCECALADKFQCDTISEYVDCKEEVRRDLITATAALAGISSLFFGLFTNLPVALAPGMGLNAYFAYQVVGTNASGSISYRTALTAVFFEGIIFMFLALTGMRQWLVRLIPATIKTATGVGIGFFLTEIGLSYSSGIGAITGGGVSTPLSLGGCPPGMINETTGGCNGGQMTNPTMWLAIFCGGILTAFLMAFRVKYALVIGIALVSIISWPRNTPVTYFPYTPEGDSRFAFFRQIITWHPLSKILNQLDWNLDSTSTTHFILALFTFLYVDIIDATATLYSMVRFCGVVNPKDGDFPRSTIAYCTDALFISIGALFGCSPVTAFIESGAGIAEGGRTGLTAAVAGLCFIGSIFFAPIFASIPPWATGCTLILVGCMMIRQITQVNWRYIGDVLPSFVVMTFIPLSYSVAYGLIAGLFVYTTLNTLIALVVFFSNNRIEPREYDLKEYWTWRGSGRAPWFVRAMRRDRRHHNTQHHDSPSLNESHDHDNVMMNNSNNRNDNNTSSSGRDDEESQRAFHLHHDPETPRGKNGDEREHEHEREREHATVHFVGDEYEYEGGSPVGGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTQ2</accession>
    <name>A0A2T4BTQ2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_148366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTQ2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="17057" checksum="8EE0E6DDEB1F5458" modified="2018-07-18" version="1">MQFQTCPSAFDTVARSQLSNTKVLVLYTRACTSTAVLTTAWHLPVLRPILWPLPLQDFFPSPPYSAFSAPPSREPSADSSLHRSAWASSCSAAFSLLFAPHPSELRLLVHDQIRSSHFARHLRAKSLPAAADLTWPGPASSSFLPRPLYLLCLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU51</accession>
    <name>A0A2T4BU51_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1425460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU51"/>
    <dbReference type="STRING" id="983965.A0A2T4BU51"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000029">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="13">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB72841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="579" mass="63029" checksum="3DE6306B6D333232" modified="2018-07-18" version="1">MAVACPICNKPVKSTDINDHLDSGCTTFISDSFSTPTPPAPTPQTPFHNGTTTTATPHSQPQSQKRSASSFFSTPAPKRQVTESKSQTPLTNAAFPPLAGKKRAFEDGPGDTPRQENRRTGGGDKHMEDRPMEDAASAAAAVNGNGADEDGRKIKKTKTHRAAPLAERMRPKTLDDVCGQDLVGPDGVLRSLIESNRVPSMILWGASGTGKTTIARCIAHMVGGRFIELNATSSGVQECKRLFAEAASELQLTGRKTIIFCDEIHRFNKAQQDVFLRPVEAGTITLIGATTENPSFKVANALLSRCRTFTLRPLGADDVVAILRRARKAEESVYPPSPLIDDEMMEYLARFSDGDARTALNLLELALSLTLRDGMTKDAIKQSLTKTLVYDRAGDQHYDTISAFHKSVRGNDPDAALYYLARMLQSGEDPLFIARRMVVIASEDVGLADNSLLTLATSTYTATQQIGLPEARIPLAHCAVALCLAPKSTRAYRGLNNAFAALREPGVASLPVPLHLRNAPTRLMRDLGCGAEYKYPPNYRDGKVKQRYLPEELQGRRFLEARDLGTEVDPDYEMDDAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUJ5</accession>
    <name>A0A2T4BUJ5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1394226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUJ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BUJ5"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="585" mass="64340" checksum="F0163E68781FAE8B" modified="2018-07-18" version="1">MEFGHRRRRHLDAGAGREVVYCHACTHEWYRDEQGLICPSCDSDITEIVSPDNDPRELDDSETSSTGPHESYPTGAGMFDHDDDHHQTRGQHHDMDSDPDEADIEEHLGPHGFHFRRSVRIRPGDEHHDPAVDPVIERFLGMIQDFAPTQRPADGARQGGDEARPAHAHPHIHRATFMNGSGSASVTIFSGPSSDFFGPGSPGHDHHGDLFQTFFSNVLRDVSPPTGGREAGGATPGFARGLQEILNLFNPAHAIHGDAVYSQEALDQIITNLMEAHPTSNAAPPASSEALANLDRRPVEEFMLEGDSKTECTICIDDMKVGDPAAFLPCKHWFHDECVTLWLKEHNTCPVCRASIEKAGGNSNSTNDQANARATATASAGPSSDGHPTGEPYATGSIFARSFPLPIPAARPQYSRPPSQSQSRLNEAMRSISTLQQERQQERQQERQQQQDREQERHRIWGIPLDRGGERQQERERERDRLWGVPSSVAYDTSRMQRRSSRTSASPTSPRMSSFADYRVRQRQGSPTQSSRRNGGDNNGSGNGNGNGSSGSGSGQQTGSSGPLSWLRDRFSGGGSRDDANRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUV1</accession>
    <name>A0A2T4BUV1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1362234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUV1"/>
    <dbReference type="OrthoDB" id="4494488at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22656">
        <property type="entry name" value="ClyA_Cry6Aa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="405" mass="45752" checksum="3680B253D4E86FFC" modified="2018-07-18" version="1">MTAIFDPTKPITDETVWFPRGMFISKNSKKLILKPHDPRLRDDNDQIFILERGQMHALCRFLWTGKLLPTDHSSYARYLGIFDTSIISDELWSEIDKLLNTYKSISEDCTEFKDDTWDKLTILSGIIKTYAVIAGGTGKSSYYQATLEWVGQYHDELKKPNPDQGTLDELSSTIKSAIEEEQGKIKLIQDQVAKALTALATFHDNCKVYETTLQGDEKSLQELLTKEGNNVADLQEKIDKERADINAAQSIIDADHSRIQQTSYYSWVVPIGTIAAAIIANEAEAEIDMIEKKIREIQTAMEADEAKLQTAKILQADITSMRGQVTDLIDIIGPAIETLEALQGAWAGMNADLQTLYDLFGDHFACSVRSLPDSIVRFCQFNKVAHYMEEKKKKKKKKKKKTKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUW8</accession>
    <name>A0A2T4BUW8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1404819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUW8"/>
    <dbReference type="STRING" id="983965.A0A2T4BUW8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="103" mass="10694" checksum="4267966D44F57FD9" modified="2018-07-18" version="1">MGQFDWFKKIGATDEAVAVLNDQPYLFTVLVVVLVVLFAEGGFLYFIHWATFKPSQRKKKPDAAKGGKPGAGASTGAAAGGGLLGRLRAGAGSDNSRRAPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVL0</accession>
    <name>A0A2T4BVL0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1339467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVL0"/>
    <dbReference type="STRING" id="983965.A0A2T4BVL0"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="302" mass="32044" checksum="57D51D22D7A1AF0B" modified="2018-07-18" version="1">MPPVWFITAASSGFGRAIALSALRRGHTVVATARDPSRIADLAAAGAHTLPYDVTSPPTVAKDLAERVFAQHGRVDYLVNAAGYILEGSIEEVSPEEVLASFDTNVFGAMRTIQAFLPYMREQPLINNAEEEAGGGGVKRGVVATFGSLGSWRGSPSAGVYAMTKWACSALAETLALELAPFRIGATVIEPGYFRTGFLNPSARVSSKARLGAYEDEGTPTGRARRGLAATDGRQLGDVDKGAEVVVDVLTGTGVAKGRELPVRVVLGSDAEGVVRNKIAETERILDEWREVIRSTDSPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW71</accession>
    <name>A0A2T4BW71_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1382716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW71"/>
    <dbReference type="STRING" id="983965.A0A2T4BW71"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="470" mass="52927" checksum="8CCE269B21C80C2E" modified="2018-07-18" version="1">MNLLLSDDYLLQDYPESMTSTIRSGHATMLRFNRTGDYLASGRVDGTVVVWDLETMGVALKMRGHNKSITFLSWSRCGRYLLSTCQGWKAILWDLQTGHRHREVRFRAPAYMAELHPWNHNLFVASLFEEQPLLVDISEPVDVKRVLPSAPKRSNADSDLALKEKQAKEDAKQMTTSAIWTATGDHIIAGTSKGKLNIIDAKTLEIIYSEKICTGVITTMRITSSGRDLLVNSQDRIIRTFRIPNLAVPDLDPDTIQLPLEHKFQDVVNKLSWNHVTFSATGEYVAASTYNNHELYVWERNHGSLVCMLKDPKEEQGVIEWHPSRPLLAACGLETGRIYIWSVISPQKWSALAPDFAEVEENVEYMEREDEFDIYAQEEIHRRRLDAEDEDVDVLTADSTKEGEDLANFRMPILFNLGESDSEDEFVAVSTGTMRRRSPGESQADLSAGAEPAAPARKKAGARGGKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWA7</accession>
    <name>A0A2T4BWA7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1382802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWA7"/>
    <dbReference type="STRING" id="983965.A0A2T4BWA7"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="164"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="415"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB73589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="542" mass="61182" checksum="FAC84C3F5D8BA0B2" modified="2018-07-18" version="1">MASTESILQGVTILGKVEDAHRKILTPPALAFLALLHRSFNPTRKNLLERRKLRQAELDRGVLPDFLPETKHIRENPTWKGAAPAPGLVDRRVEITGPTDRKMVVNALNSDVWTYMADFEDSSAPTWDNMINGQVNLYDAVRRQVDFKQGAKEYKLRTDRKLPTLIVRPRGWHLEEKHLLVDGEPISGSLFDFGLYFYHNAVESQKQGFGPYFYLPKMESHLEARLWNDVFNLAQDYVAIPRGTIRGTVLIETILAAFEMDEIIYELRDHSSGLNCGRWDYIFSTIKKFRNNPNFVLPDRSAVTMTVPFMDAYVKLLIQTCHKRGVHAMGGMAAQIPIKDDKEANDKAMENVRADKLREVRAGHDGTWVAHPALASIATEIFNKYMPTPNQLFVRREDVKITQNDLLNMNVPGSITEEGIKKNLNIGLGYMEAWIRGVGCVPINYLMEDAATAEVSRSQLWQWVKHGVSTAEGKRVDKAYALRLLKECADALAAKAPQGNKFQLAAQYFATQVTGEDYADFLTTLLYDEITKPGSPSPASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWC9</accession>
    <name>A0A2T4BWC9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal fungal transcription regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_135839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWC9"/>
    <dbReference type="STRING" id="983965.A0A2T4BWC9"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="364" mass="40296" checksum="4D2D9735E78DE7C7" modified="2018-07-18" version="1">MVAHSLPSPPSEDSKSSNSPPISTIPRKSSGSNTKPVKGTNRASKRAGSGAAAMHRHDQVTHGMDGRHKRVWKACERCRMKKTKCDGEFPCKRCKDDGLVCTAGVRKKMEYKQLPRGYAEVLENTQFALIATVHKLYQMVRTNQSWDLGEPELNDRGQPVIHNIAQKLGCIRPNSDIDLPVHSIFPENTQDLEELARQLNDHHADAQNKDRDTEIESESPSAYRRTDRASSSDLDHSDLELEHRRTTFGGLNNSHPVTMSPQSYAGSSTEFEFNQSAPSDLDASAALFSANSPQLPIFPEWAMKTASSDVAAMQYFQQAIHLGHPIMEGYETIKPQALSNAGGVMMGMGDPMMYTPFDVDMVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWV2</accession>
    <name>A0A2T4BWV2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLAC8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1339101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWV2"/>
    <dbReference type="STRING" id="983965.A0A2T4BWV2"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16585" checksum="A344244E742069A8" modified="2018-07-18" version="1">MSSQEETKGNESTWTQGLFDCCSPAGLCCLTCFLPCVTYGKAQHRMKHGSLDNYSCCNASCIVYALLAHCGLGCIPTTMQRGEIREKYSLEGRCFGDFCKSCWCNCCTLMQHEKELEQRQALLKGSAEPYQPIGGMVYSDQAQQSNPGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX05</accession>
    <name>A0A2T4BX05_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX05"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="16781" checksum="67D5C0C6EC891B56" modified="2018-07-18" version="1">MECFAPRDSAFYTTQEYGYKHADSTLSKQYLRACIAINAVNQVVSRHITIRSTAKKQTNLTLASPCPPTSEQPLNPPPSQSFETDKHKRNSGNSIKAGSQLEADAHPSPTQPSQCLLHASNPDMHPTAAGCLTASCLARSDEQLVIGPHGRTHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXC7</accession>
    <name>A0A2T4BXC7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1471975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXC7"/>
    <dbReference type="STRING" id="983965.A0A2T4BXC7"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015586004" evidence="3">
        <location>
            <begin position="21"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="84"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="446"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="57357" checksum="8FE41E5814E07A0C" modified="2018-07-18" version="1">MKRTLNVILLFSGLGCKAHSWNDRGMVYGFDNIKPSANLTWTPCFDDFTCSRLEVPLDYSNTSLGTTSIAFIKLAGKNATLESPSLIVNPGGPGGSGIDLLLSNRALASLAFGEQYNIISYDPRGVNNSGLTLDCFSGNTEARTAFSRLHSTGVTNISSTSFEEQYYSSSIYGEWCNNAVAKDSPHGYYVTTPAVARDLLTFIEAEAELVGKAPSEAKLWLYGISYGTVVGATFASMFPDRVGRMVLDGIVDAEQYYDNAWSVNVDQMDEAMETFSSFCHSAGPERCSFWGPTPANIIARMDNLILQLKNHPIPISNVQSGGLPALVTYSDLKALFVNTLYVPAASFPVMADILHQLEGGNASALAGTFDGLSVAFDAGHVIQCADSYRRNKLTSIEAFKSYVEHTVSKSKYIGDVYPIFVDSILCRSFRPQLPDSMVVQGRIGLNKPTSFPILIASNTIDPITPLSSARRTSSRFPGSVLLLQEAVGHTVVNQGGSTCYFAHVQAYLQGILPPSNTTCPQQFVPFVGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXL3</accession>
    <name>A0A2T4BXL3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1446580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXL3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXL3"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="37112" checksum="F3AA9EE0726F20AF" modified="2018-07-18" version="1">MTASIPNFQTAALIKDPGPNARIQIRHDYPVPQPGRNEVLLKMECSGICYSDIYVYTGNNPHYDEVPCHEGVGKVVQLGPDVEDTLLGQRVGLGWIYSVCGHCYNCAAGRDNWCVNQANTGTDKPGTMQQYVMLSSSRAAPFLCGGITMAGALSLCDDALADGDTLVISGSGGGLGHLGLLLAAKLKSKRDLKIIAIDTGSIKKEFSLSLGATSFVDFKSEDVIQKVMELTDGKGADAAIVVPAATEAFGQALKYLKFTGTMICAGITRMDYRLPVSPTELEYRGLVIKGCHVGTKEQLEGLLVSAAKKEVVPRVEVFEFDKTGELFERIKRGDVVGRFVVEIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYH2</accession>
    <name>A0A2T4BYH2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1440487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYH2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYH2"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="641"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="81306" checksum="BCEB14B334E01F46" modified="2018-07-18" version="1">MYNDDYHRGRHDQARDNDYPSSSYRDRGYSSRSPPPDYYSRSRSRSPHREGGGRVGDAGLPSDTVIFEGLPVGVDEVELRESIIRDCIPDESSIVDVRLTYAKRKRRAFIQFEDVDHATALINEHFPKVHFTLPYTTDEVPDGKCSAFIHFAHRRADGDTRAGGQWICQPCGFDNYSSRTKCKRCGSSPLSSAMRVSLIPAADAGDAPTQILVVYPLMPYVTEEMFAADMKRLELAKPDPASQKLAPGSKLQSTAPADRAARTGARPGSLHRVFLMRDSVTDESVRYGFAEFWTLQDAVEAMAKIKLLPSFSVAAAPVTVSHIHLGVFVPEEREVTPEMEKFSFSPLFNPSLRVRYRDLRAYPSQKVLALEPPGSAGAEGEQKGGDQGGNNKKQKKRKADDPLSAAAKRAVPAMAGHMALWQKKHEEIHTNESGTTAAKQLPAKDAKEAPIKFAFPGASSAHASGAQAASTPAQPAQPAPPAPSSAPPPPPPPPEKQNGDKMPAAKPDGQAKAEKPITPYADREKLQCLLCMRKFKSLDELGRHGNSQLHTEKLSDEQSIKSALERLSKRGIPLPTQTEGGDDASNAAAPQYRDRAKERREQWNQPKKPLPVAADKSAPAPQKKDREKEKEKAAAQEKAPAQSKGAGMLAKMGWTSGSGLGANAEGRTESIVTHVYRQGVGLGAEGADLGTAQALGESRTLNNRKDYVDAVNERARERFFSEFGGKKDGQPNGEDKDGDKGGDSKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYX5</accession>
    <name>A0A2T4BYX5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1432554</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYX5"/>
    <dbReference type="STRING" id="983965.A0A2T4BYX5"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
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        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB74465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="386" mass="41782" checksum="9C7DC131BBA8F2FE" modified="2018-07-18" version="1">MSFSSLVQELSLRDANNARRPGPAPSVSTSTFDDRASHISRTMSGYASTAATSVSISGDIGSQLHGGYFHPLARSWQSERQLTKSMLIYPIFVTDGEDDMVHVASLPGQFQISIDRLVGFLEPLVHKGLRSVMLFGVPQKPGTKDALGSAADDPEGPVIQAIQLIRRRFPQIFICADVCLCEYTSHGHCGILRDDSSLNNQMSVDRISDVAIAYAKAGAHCVAPSDMNDGRIRAIKLKLIEEGIAHKTLLMSYSAKFSGCLYGPFRDAAGSAPAFGDRRCYQLPPGGRGLARRAIVRDINEGADIIMVKPAGQYLDIISDAKELGKDMPVAAYQVSGEFSMIHAAAKAGVFDLKAMAFESTESILRAGATIVISYFTPQFLDWLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ07</accession>
    <name>A0A2T4BZ07_TRILO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M440DRAFT_1440615</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        </location>
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            <begin position="11"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB74476.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="PTB74571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="14381" checksum="891298AA1E998969" modified="2018-07-18" version="1">MHLFPAFEPSDFGFGPVCNHCPISSRGYLQGVVPWSHYDYLRGKPKETGRSRRNGQRRKWRADRQYSELHTACYRDRFRLIVTSPHPPLRDANSLPLIVSPADGMPLHERSMPVLAAFPQRPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ57</accession>
    <name>A0A2T4BZ57_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1028358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="139"/>
            <end position="160"/>
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            <begin position="1"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="284" mass="30627" checksum="AAC5A048A5427BF1" modified="2018-07-18" version="1">MEREKKGDGPSAVISIAPPRGHYPLKRSRTPLYSPLSSKQKLGLLVLGAILPPPRVEVISPWCNGSVLLDIVEGGGGRPGPGGKVGAFALKRGHKEKRRQGGVRPSSVAPGLSLREELARAGYFLAPVRPRLRKPQTRFFLLLLLLVAQVTKSLVSLGGVHEERRFVVARNPAKETSEKLPVGLLGPLNPSQSPELEALRGPRSPQEAPKELLESFHGSPNGGSLTRDPLCVHARTSNVICHWLVRGREHVKAASHVECMSNLVQSPQLQTLSFFGVAVPGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZA0</accession>
    <name>A0A2T4BZA0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L22e</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">M440DRAFT_1319447</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BZA0"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="106" mass="12198" checksum="AA18C53FB0009FF0" modified="2018-07-18" version="1" fragment="single">QFIINASQPASDKIFDVSAFEKFLQDRIKVDGRTNNLGDDVVIQQSGDGKIEVIAHNELSGRYLKYLTKKFLKKQQLRDWLRVVSTSRGVYELKFFNVVNDDADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C087</accession>
    <name>A0A2T4C087_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_106818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C087"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14199" checksum="63B15EDF4D3B8642" modified="2018-07-18" version="1">MRRRRGRFGRNRRWQKLRRCRRTSGEGISRGRGRSGGICVLYTIVCCGRDCAVFQRWSTLSHKGPIFLLIVVSFRPFYLSEAQKPSIIWLLFSFVSQLRCFHCSVLFVVAVFALIFVCWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0D3</accession>
    <name>A0A2T4C0D3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_364331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0D3"/>
    <dbReference type="STRING" id="983965.A0A2T4C0D3"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015610845" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="460" mass="48126" checksum="26B74B5E5B3E8215" modified="2018-07-18" version="1">MASRLFGLLLLAIPIQAQSPVWGQCGGIGWSGPTTCVGGATCVSYSPYYSQCIPSSQASSTIASTTLVTSFTSTSATRTSASTPPASSTGAGGATCSALPGSITLRANAKLNDLFTMFNGDKVTTKDKFSCRQAEMSQLIQRYELGTLPGRPSTVTASLSGNTLTINCGDAGKSISFTVTITYPSSGTAPYPAIIAYGGGSLPAPAGVAMINFNNDDIAAQVNTGSRGQGKFYDLYGKSHSAGAMTAWAWGVSRVIDALELVPGARIDTTRIGVTGCSRNGKGAMVAGAFENRIVLTLPQESGAGGSACWRISDYLKSQGANIQTASEIIGEDPWFSTTFNSYVNQVPVLPFDHHSLAALIAPRGLFVIDNNIDWLGPQSCFGCMTAAHMAWQALGASDHMGYSQIGAHGHCAFPSNQQSQLTAFAQKFLLGQSTNTAIFQSDFSANQSQWIDWTVPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C136</accession>
    <name>A0A2T4C136_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">M440DRAFT_1402817</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C136"/>
    <dbReference type="STRING" id="983965.A0A2T4C136"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="929"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="976"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1062"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PTB75281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125081" checksum="1AE8B86825E7F18F" modified="2018-07-18" version="1">MQALTPHDSRRNWPLTTPIWTFKFDYRPRFLLHFLTCFLPLRFDLFLSDSSGIFRRIKILAMNQKSGEEPAHVSGQANSPMSAPAHALSFRQVAEELNANLEDGLTTEEAKRRLSQYGSNEFGEQEGVQPLKILLGQVANALTLVLILAMAASLGIQSWIEGGVIAAVILLNIVVGFLQEFKAAKTMDSLRSLSSPTAHAVRNGNNEAVVTAEIVPGDLVELKTGDTIPADIRLVEAVNFETNEALLTGESLPVRKEVNTTFPDDTGPGDRLNVAYSSSTVTKGRARGIVFATGTYTEIGQIAVALRGKPSRRREPKRDAEGKALAGRWMQAWTLTFFDAVGRFLGVNVGTPLQRKLAKLAILLLGVAIVCSIIVLAANEFNTKKEVIIYAVATGLSMIPASLIVVLTITMAAGTKRMVQRHVIVRNLKSLEALGAVTNICSDKTGTLTQGTMIVKKAWIPGRGTYSIGATSEPFNPTTGDLSLQESQPKDIDFQAEDSEGVLINPEQLAAQDRALRAYLNIASLANLATVHQVEGKWHGRGDPTEIAIQVFASRFNWNRSRLASGEQPRWREVAEFPFDSDVKKMSVIFEDSESQKQWVFTKGAVERVLTSCTGYTVGDEVRELGEDVKEDVLRNMESLARLGLRVLALASRTDIPSVIDNTADLDRSQFENHLIFRGLIGLYDPPRPESAASVKMCHQAGISVHMLTGDHPGTARAIALEVGILPEKISQIPKDVAKSMVVAASEFDKLTDAEIDNLPLLPLVLARCAPQTKLRMIGALHRRKAFVAMTGDGVNDAPSLKGADVGIAMGLSGSDVAKEASDIVLTDDNFASILNAVEEGRRMFDNIQKFILHVLAENIAQACTLLIGLAFKDRNGLSVFPLAPVEILWIIMITSGMPDMGLGFEIAAPDIIQRPPQNLKQGVFTPELLLDMVVYGLWMAALCLASFVLVLYGFGRGADDIGENCNNTYSEDCRVIFRARSTTFACLTWFALFLAWEMVNMRRSFFRMQPKSKRYFTQWMHDVWRNPFLFWAIVAGFVTMFPIIYIPGLNTVVFKHAPISWEWGIVFIEAVVFFMGIEFWKWLKRVYFRRQARKASCNVTDLETRVFGRYYNMGTGSQDEETGAGTREKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1L2</accession>
    <name>A0A2T4C1L2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1402971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1L2"/>
    <dbReference type="STRING" id="983965.A0A2T4C1L2"/>
    <dbReference type="OrthoDB" id="4150765at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="160"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="579" mass="63597" checksum="B9B9555D06E6CCC6" modified="2018-07-18" version="1">MTYFVGTEESISDLGDLNMSFQTQRFPYKNEHESSLRGGRTSHRSTMSSATSISWPSPSLSSQPGGETPHDLSRPMTPVNLGTSGPESVISSTDSAMSSPVASMSASRISSSLSLIGPHQGGIGLFQNSPDGAAESHTPQLIMPSLTVPRRRPFSETGKSLGKLKVLVTGAEGIGKSTLITAIAQSSEHIVHVDPITNQNKGQVSEVYASTRPYPWWRAELDPSVAPRRRSSAAMDEMLDRNLCFVDCPPQRESDGMHPAVRYIESQLFPLLHRPVSDGDLWNLLSNGTEPIVDAVLYLLPHTGPEPTDIETIRVLQRTTNVIPLLARADEIDSREAMALKQNIGGRLRDKDVAYFSFSAPGLPAEASDVYAVSSISDSDHDVMDASVLMNSEYVRPLVSTDLKKLVEQLVSPDGSARLRHSASLKCVRWRRQKAISSSSQSALICRQPMEMYSFSTPSWGRPFLPEQYHRPLEMASWAESLRLSLEAERLGETPMQLFGPSITVNMPLARVNQKSRRQKSKKSKREELVSHHQDPLGLLGLAGQIRCNSRLTLELVSSIGVIGYFTSWLVRPDGLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Q1</accession>
    <name>A0A2T4C1Q1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1377893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Q1"/>
    <dbReference type="OrthoDB" id="76038at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="216"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="547" mass="60854" checksum="3B21B2B2398925BC" modified="2018-07-18" version="1">MSDTIQEVYDVIIVGAGPCGLATASRLREHTPAALFTDEEHRRYHWIGKYGKQVALKHVKSGKVSHARHARASRPEYKMLVLDATDNKWLGRWNHLFKTYDISHLRSPMLWHVDPLDRDALLAHAYYHQREDELVEIRNCVGKEISKHASKKMAKRQVCGGKQEARIDINLRDRNDYYTPSQALFSDHCAQVAGRYDLEGQLIRKETLQDIDYGEVRGISVDGAKLFTVTTDKTRHYYAKAVVLAVGPANTPKIPPLPSAPFTASGVLPQACHSMQIKQFPDALVQSRIAAGSSTNILIIGGGLTSAQLAVLALKKGVTKVWHLMRGPLRIKHFDVDLSWMGKYKNAEQARFWTADSDLERLAIIKEARGGGSLTPLYYKKVKKCMAAGTLELRTLTTLVDAELKDIDGSSFWSVKTEPPIDGLPAFDYIYFATGIQTDFACLPYLQTMLQKYPIHGHGGFPCINEDLMWKDGVPLFLAGRLGALQIGPAAPNIGGAKVAAERVAWAIEDTIRPDSFQDDHEESNSGLASYLSGHGNMYSILQEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C277</accession>
    <name>A0A2T4C277_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1334764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C277"/>
    <dbReference type="STRING" id="983965.A0A2T4C277"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="352" mass="37505" checksum="E06F755A69B50FDF" modified="2018-07-18" version="1">MGSIAVPQTVKQWNVVSHNGFDGLKFSEQPLPELGDSQVLVKIEGASLNYRDLIIARGEYPFGVAPNVIPGSDGAGTVVSVGKHVTRFKPGDKVITLFNQGHLGGSLTPQSVATGTGGVLDGTFRNYGAFSEEALVRCPSHLTPVEAATLTCAGLTAWNALFGSANHIVRAGHWVLVQGTGGVSIFALQFAKAVGAKVIATTGSKDKAPLLEKLGADHVLNYKEDPNWGETAKRLTGGRGVDHVVQVAGAKEMEQSIAAVKMEGIIDIIGFVGGTADKEPGFLQCLSNLFTARGILVGSRTQMEEMLEAIEAHPEALRPVVDEKVFKLEELKEAYEYQWSGKHFAKVCLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C278</accession>
    <name>A0A2T4C278_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1439359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C278"/>
    <dbReference type="STRING" id="983965.A0A2T4C278"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="428" mass="48158" checksum="64C1C480D4D407A3" modified="2018-07-18" version="1">MAVPPIHVPRRHTLNLEDYFAGPRDMDKHSKWPLFLQMHGSILPKMIVPLICMSAWSTCITLIYMKAHKNIAVNSILLTVLGFVVSTGLSFRGSTAYERYAEGRRFFASLVTSSQALGRVFWIHAKPLPDVDMRRQILYKISAMNLVVAYAIALKHSLRFEPYTAYQDIEHLVGHLDTFAKSATTTMPTNIGKKNFFKSVGDYLGLSFAASNPRKQLKKAAKPLGNLPLEILNHLAVTIDDLVGRGQLPVPMQQTLAYNNLAALNDAYTGCQRVLNTPLPIAYSILFQQITWLYVILLPFQMVGVLNWITIPATTVASYIILGLLFIGQEIENPFGHDVNDLPLDTYCEQIALDMDIIASHANYKPEDFFFSSENVPLWPVSAAPADTWLQRSEAKLAETIRTKPNKTFEWRRWRGEKAGDEESGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C387</accession>
    <name>A0A2T4C387_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1470147</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C387"/>
    <dbReference type="STRING" id="983965.A0A2T4C387"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="288"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="635"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="786" mass="89524" checksum="DB1100E9DDDBD7B2" modified="2018-07-18" version="1">MLPQHHNAKRNNPLPDATSSGQNESRTVPFHLPFNGGEGLAASDILKLHRKHSRQWAEKLRKVIGVKGRNDHGLIRKLRSNDPKTSPGSTIVVSDSSLQQHSSFQDLAGVLESDDSSEQDDIWSSTHSSRLASPEDNLTGKTSIDSRLSSPRSAKGSPRRKLSRRSRWTRSSPEGAALGTIEETATDRPKPTIVTVERAAAAKIFLETHFNEVCGELQRRSVRCQQFAHQQFKDGLFNSQNLASGSSGLNYSTFYHAETCRLRDIRALKAKCTIQAKRQNASPFASKYEPLKILGKGSFGVVRLVREKSDSPNTFSKQVFAMKVIRKSDMLRSSQEGHLRAERDFLVSYEGSNWVVPLIASFEDMSNLYLVMEYMPGGDFLGLLIRENILHEAVACFYIAEMILAVEEAHRLGFIHRDVKPDNFLISSSGHLKISDFGLAFDGQWPHDASYYSYHRYSLLQKLNVDAKGDEKDQEDGKSVQARVEKAQALTADLGRHDEQDFGHDRDLTAVLGWRNMCSNRTRANSVVGTSQYMAPEVIQAQNYQTYYDDEGRKPTKQNILAHKERFRFPVRPLVSDKCKDLIYRLIQDKEVRLCSRRYQMLDQSQSGAALPTDMYGRFVFPDDAEDIKAHRFFRSVPWDNLQNTAPPFVPRINSIEDTHYFDESEPLDDRVDSATEKPGLTDEEVRWVLREFRPCVQNVAIRLINIPYDSGALRSRDLEIDSMTAFAEEEKELLKRFMREYGRRVPKRPRDIVLRDESMKGTAMEVRKQSAFMGYAWHSVRKQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3H6</accession>
    <name>A0A2T4C3H6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 23 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1333343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3H6"/>
    <dbReference type="OrthoDB" id="2392789at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="67174" checksum="7DCD4A95FE63F97E" modified="2018-07-18" version="1">MAPLDLSTHTKVMIAPPRLNLRRNASYNNYDKAPLSSTSARFNFNHLLFSPPPSPSLPVLVPRPKKSPAKVLIARPSRVLRYTLYLATLLATFYFASLVFRNKESIIAVWPHFTTEEFEMVGQDALPDFPTPIVVSHSHSRAKWTVSIPHDHDFPLSVEEYAGMGSKCREVSAHTRELGGKAPQTHQDKLKYDAVDEYFVDVHEAERSGLLPAAQHGSAAGKTGHFVGLNWESMAGLPVCKSSVTYVLESSDAGLGTAVMSMWMLYGLAKHQGRAFFVDDSRWAYGRYTDIFEAPPLPDCRPPPRHQMLPCPAQARHLVVTGTTLKDVFPALMAKYHRAAGTSNNLRDLMGLARSGYEALFKLNGDDQGFVHNRVKELRKQQMDRDPALPAVPIIGLHIRRGDSHPLEYQYRNTYIPSEVYLSKAQELVSAYYSSSEAHDTVASNRSITLIASDDPAVYKQPDFSDALIAQERIRLASKEVAPREDVDPHVLHQFKDEGMGWEGGFFASMFWNLGFDRKHNGHANGASSGRTEAPSEQTLQLRSYMGRAYMLDLAVLAGASDRIVCTVSSMGCKMLGVMMGWEAGIEGGGWNNVDGEYPWAWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3R7</accession>
    <name>A0A2T4C3R7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1332942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3R7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3R7"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="402" mass="43606" checksum="50657B0EB33E41BD" modified="2018-07-18" version="1">MHHGQSAMPPPKSPSGSLRGIQDSAMAASMRANPTHYLKRSFSTPSVGGATPSSFLESQSLAPQMGEKKRNKLGYHRTSIACGHCRRRKIRCIISTDDQNRCVNCIRLKKECSFHPVDQQQPYDQKQPPQTPGSSSTVTASSSPAISRGSSVDQGTQRHHYPSMPVASLPSMGNPAIQTPQGEFFPPDMEVSSNNVPPGPSYGIGEPPSTGWMTADTNSDTMAKPRDPSAIWRPFPAEVPIGVSGQLSPYANPSACSTTWTNSNYAAGSDMGWNSSSMPPPPRSMSFSGEMLGSQGTPHYYPVPHQNQIYERQSQQFPPIYGGVPVGGTDEGIEHAIDPAIMSGTVQPATPIAWQQQQQQQQPRTQTQQPQPQLMSQQIPDTQGGAYRPWAEYGEGDRSHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C442</accession>
    <name>A0A2T4C442_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1356224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C442"/>
    <dbReference type="STRING" id="983965.A0A2T4C442"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="264"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="607" mass="69025" checksum="DF1D759692EDDE9D" modified="2018-07-18" version="1">MADNQPAAGDAVADATAAVSKLHLDEVTGEMISKTELKKRQKAREKEAAKKEKEAANKDKKPAQAAGNKNAEAAEKELTPNQYFEIRSRTVNELHAKGKAYPHKFHVTYDIRKFAEDFANLKNGESDKSKMLSLAGRIYVRRSAGSKLYFYDIRSEGARLQVLAQADNREEGTPDFDEQHLHLRRGDIIGIRGYPTRTNPKTKQGSGDYSGELSIAAVEVILLSPCLHQIPDDHYGFKNPEQRFRQRYLDLMMNDNVRNVFITRAKVDSYIRRWFDDRDFIAVQTPMLNAIAGGATAKPFITHHNDLDMDMYLRIAPELYLKMLVVGGLNRVYEMGRQFRNESMDLTHNPEFTTLEFYMAYADYYDLMDMTEELVTGLVKHIHGSYKTKYHNIKGEEVEINWEGPWRRIEMIPTLEECVGEKFPPADELHTDEANQFFRRVLKKTGVECNPPLTNARMLDALVGEFLESQCINPTFITGHPKMMSPLAKSSRETPGLCERFEAFVCKKEIVNAYTELNVASEQRERFEEQARQKAQGDDEAQGVDETFCRALEHGLPPTGGWGMGIDRMMMFLTDNYSIREVLAFPTMKPEQTLGVTEKAAEGLGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4A4</accession>
    <name>A0A2T4C4A4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1391883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4A4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4A4"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="424" mass="45795" checksum="EB7CFE5CFA2776F6" modified="2018-07-18" version="1">MPFRQRMARHFGDSVCRLQRLTYTLLRPFAHTRFCHSLLRDARMLTSLDRQLAPEKAYLSYYDVLLTVEDIKSLKEGLPLQQQALSEIVKRPIRFVNLDDSPQQENGSDCGVFVCLLMRHLLVKRLLVANAREKVSMSMAGKMVDSNGGRKEMLRIIENLRKEGEHFQKLLHEPGRQGDGSTEQLLTPASTPPDPKKPAVLADDAKTIQAKGGAAKKTTNSKTRALKAVASIKGVASGAVALTKAVAPGLVASKTASKSVVSKTDASKAVKSSLSISKTVATKAVASQTVASKPVASKTVAQPDRRASAKAPGKGQIQTPTTAKRPAKTTPSKSSSPKVTKTTKATPSRSITPTGKPHQRARGTRTPVVRMVRIQPPPRDPNKPTMLEIKFASNKGLPKKAPTPTPKKPAAAPIKDRGLRAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4U9</accession>
    <name>A0A2T4C4U9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1392026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4U9"/>
    <dbReference type="STRING" id="983965.A0A2T4C4U9"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="494" mass="54498" checksum="3E35C40927DE8ACF" modified="2018-07-18" version="1">MGDNIPTTAAEGQAEGKKQMILNAFVMNTPGHLSPGFWRHPRNKTDQYTKLSFWTDLAQLLDKADFHAMFIADTLGPYDVYKGPANVVPALAAGAQFPVNDPLYLVPAMAAVTKNLIFGVTASLTYEKPYALARRLSTVDHLSDGRVAWNIVTSYLDSAARNHGLKEQIPHDERYAIAHEYMEVLYKLWEGSFRDDAVVKDRENGNYIAADGVVQIHHKGKYFEVPGPHFCEPSPQRTPFLFQAGVSEAGNGFGGKHGEAIFVGGQTPEGVRKTVDNIREVARKEGRDPSHIKVIVGINVIVAATDEEAQAKKESYLQYADQEGALALFGGWTGVDLSGYADDEDFRFTDSPRLQSIVRRWSDTVPGTDNLPWTKRRIVEYLSIGGLGAKVVGGPTTVADELERWIEVSGVDGFNLAHVTNPGSFEDIIEHLLPELRRRGVFRNGVDKEGATAREVFIGSKRLPEDHPGSSFKWRAGESTPKYLQKVDEEASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4W2</accession>
    <name>A0A2T4C4W2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_19813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4W2"/>
    <dbReference type="OrthoDB" id="4887794at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18897" checksum="46D2E2E235481444" modified="2018-07-18" version="1">MSVDIIATLKILIKLGSEIKTRLDSLDQAAEDLQLPTTNLKLLLIVFQDPVNILQSIAELCTKCAKILVINLDRATIATDKIGTRGMKFVKRIRAFNKMPDLLNEVQRKAEQLQKIHKAVSTVLIHDIRAQQQKRTGKDIVKSTSSIKTSPGLESLLELDISIELPNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4X0</accession>
    <name>A0A2T4C4X0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1332157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C4X0"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1338"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1516"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1659"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1977"/>
            <end position="2014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2669" mass="289217" checksum="EE999536BBF11637" modified="2018-07-18" version="1">MSERAPSGSAAEGAIDLARSAQALASSSPAVRIAELQLLGEAVARKPSDDELSSQTLQLLFNTHASYQDRESRLAAQKCLVSIVTRDDPSATLKLLVQTLQEESSKQGIATSSAFVLVEWCSVLLQHLSEPSWAAFGSGILLAYADALEKCVRPSSRPTLAHSAIIVTRRGFRKLFSSPTSGPRNVTDAVTNLTSARSKPTARYSVILGVIAGVAARRPVVRPTLESLKPQYYEFYNREILGSRTALPSHIAAGLGDFFSSFAVLDELQTQVVPILEKSLLRTPEVILGGVLQSLVKDLPAEFDLSSLLTGKLLKLLLSNVKSTNASIRNGVLSSFCAIIARCREPVSIDNTIEEIGGPLKAGKLASAEQRVLHAEMLQAIPLACPSAQKVTGLLATVAGKEGNEVALAAETLTLCRAINVLLQGDSEVSQPVLSVLLKGLADKKAATRKIWLLRVGSVFRAIDGLDQNAALSSFAEAVVPKFIDNFNEVVANPTLTAQSGIIVGAYILTALFPLMQRWLADSKVGSDLSKLSPPTLALASPQSFLLNAKIFNKIASEEDSHWFRLALSSVAAKLGSTTSKEAHLAWAEAFIHLVTASTIPSNVRQESAKSLSALYAQNPSVIADVITDGLWSHLMQTVHAGDKDLASETRDLVRALKAICISSKEVEALGGTVSEETLEHQACSLLIICRTELIPRASWIDSCLRMGIDPGRLATKYADTLLNKISERTSVHQKADVIRTAAYRAAAELAFVAPDAIIPRLTDLINQDLDPQPVSAIGPVDAAIFRTPEGTCFVDVLSKKGQNETINKNVKDYDTLKWEMELRDQLEKKKGPQRKLTAEETSKVNAQLKKEAQIRASVQAIEARLLRGVGIIRSLAIGPPTDATLWLGSAINSLLAVMEAGASLIIGDAASKVYIDCADKVNSRLGPIRPAIGIATLRLRNLSPPGGYGDEEIADLTTRVLYKLRFAGEQRPFDAVSLIYIFPLLFHILREGGVGATLDDRDTQTVLAVEFISFHSITFAEESIPRAELLTVLIHSMQNHAQHYKLIKDCFSDICRCIAPNISAEEMMVLARGATVPQANVRTAVLQSISADVDMSELGSSSEIWLACHDDIEENRELGTEIWEESGFAVTADLPMLMVPFLQSKDGQLRRAAARSLAKAASAHRETLQNVIQALESIYLEMAKPKVQLLDEFGMPKKMDLSDPWEARHGIATAFKELADVLDSSQAGHLLDFMIQSGPLADKNASVRTETLDAAIRVIEFQGSSIIDELMKKFETTLEQPDKNSDEADRVNEAVVIMYGALARHLQPGDEKIPVVIERLLATLNTPSEMVQFAIAECLPPLIRAYPSKLPEYIQQMMNELLNSKKYATQRGAAYGLAGLILGRGISTIREFRIMSDLRAALENKKDAHQREAALVAFEVLSTMLGRLFEPYVIQIVPLLLTGFGDANADVRDACLAAAKACFGKLSSYGVKKIMPTLLEGLDDQQWRSKRGACDLLGAMAYLDPNQLANSLPDIIPPLTAVLNDSHKEVRAAANRSLKRFGDVINNPEVKSLVDVILKALSDPTKYTDEALDALIKVQFVHYLDAPSLALITRILQRGLGDRSNTKRKAAQVIGSLAHLTEKKDIVMHLPVLVSGLKLAAVDPVPTTRATASRALGSLVEKLGEDSLPNLIPELMQTLKSDTGAGDRLGSAQALSEVLAGLGTSRLEETLPTILQNVESSKPAVREGFMSLFIFLPVCFGNSFSAYLGRIVPPILAGLADDVESIRETALRAGRLLVKNFAIRAVDLLLPELERGLADDSYRIRLSSVELVGDLLFNLTGVKAGAEPGDEDDENVKEASASLKEVLGEEKRNKILSTLYICRCDTAGAVRSAAISVWKALVHSPRTLKELVPTLTKLLIQRLGSSNMEHKVIASNALGELIRKAGDGVLATLLPTLERGLQTSTDTDAKQGICLALRELISSASPESLEEHDKTLISVVRTALIDSDAEVREAAAEAFDSLQQIFGKRAVDQVLPFLLNLLRSETEAENALSALLTLLTEATRSNIILPNLIPTLTTPPISAFDAKALASLSKVAGAAMNRRLPNIIQSLMENEINCTDEGLREELATSFDTVIQSIDEYDGLNTVMNVLLSLLKHEDHRRRAATARHLRNFFASSSVDYSRYNQDIIRSLLNSFDDGDSDVVKAAWAALAEFTKRLKKEEMESLVVSTRQTLQRVGVAGANLRGFELPKGISAILPIFLQGLINGTVEQRVQAALGISDIVDRTSEASLKPFVTQITGPLIRVVSERATEVKSAILLTLNNLLEKMPTALKPFLPQLQRTFAKSLADPSSEVLRTRAAKALGTLINYTPRIDPLITELVTGAKTTDPGVRTAMFKALYEVVSRAGANMGEASRSAVLSLIDADADERDEAMVVTNAKLLGALIKNVADDVATSLLRNRVITPQISHSSALALNAVLVESPSILQSSGIMDELPGLLCGGMKDKRTFIADNFILATGKLLLSSPPKSFDDIKQIFDTLAAVIQPGNATDSRRLALVIIRTLSRKNADLVRPHVSLLAPPIFASVRDPVIPVKLSAEAAFIELFSVADEESRIFDKYMAGPGNDLPPNVKRSMSDYFKRVAMRLGVQARERREAEGGQGGLGLSNDELEDEREIWSVGKVEIDGEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5B5</accession>
    <name>A0A2T4C5B5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-carboxy-cis,cis-mucoante lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5B5"/>
    <dbReference type="STRING" id="983965.A0A2T4C5B5"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="373" mass="41855" checksum="BE2DB58A908E2E7B" modified="2018-07-18" version="1">MPIHHLMVGTWTPPGAIFTFAFDDEALTLKLVARTEIPQDEPISWMAFSHDKKTIYGAAMKKWSSFKVNSPTDIVHQVSHPMLHHPLAASPSTNTRAIFLLPARKPPYAVYCNPFYDHAGHGSVFAVDPSSGALASNVQNYEYQPDSGIHGMVFDPTETYLYSADLRANKLWVHKKKKKTDTSSSSSSSSPDLELVGSVDCPDPRDHPRWVAIHPSGHYLYALMEKGNRLCEYLIDPATRMPVFTHRHYPLIPPGIPDRWTQYRADVCALSHSGRYLFASSRANSFDLTGYVAAFKLSDCGAIERQICLNPTPTSGGHSNAVAPCDWSDEWIAITDDQEGWLEIYRWQDEFLARVARVRVPEPGFGMNAIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6G7</accession>
    <name>A0A2T4C6G7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1437743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6G7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6G7"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="293" mass="32898" checksum="4EB9088982747195" modified="2018-07-18" version="1">MANTKASISYYDSDDDDDLPTLDVLLARLPGRTPQLQPSRSKTSKITSAKKQTKKLFEAKKTQLATDFLRQLDSRITHGKIGELTESTGGVKIVWSNTLKTTAGRANWKREAIITKQTADSGTAGVKQYRHHSSIELSEKVIDDELRLLNVIAHEFCHLANFMINGITDNPHGKEFKAWAVKCSQVFASQGIRVTTKHSYEIDFKYVWACTACGCEYKRHSKSIDPKRHRCGACKATLEQTKPTPRQNPSTGQLSGYQLFVKEQMKVVKSEHPTIPQKEIMGMIAEKWAKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7W0</accession>
    <name>A0A2T4C7W0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1400607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7W0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="60" mass="6560" checksum="DB00414965F31A51" modified="2018-07-18" version="1">MVVAARILTLPCLLCLSTGLNLLLLSLASGAFLFMEICVYLKEQGTILRVSLPFHQKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C848</accession>
    <name>A0A2T4C848_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1329962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C848"/>
    <dbReference type="STRING" id="983965.A0A2T4C848"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="194"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="566" mass="61202" checksum="899B84ECA9220E31" modified="2018-07-18" version="1">MPCFKGIAVSIHANSAPLPEYGIQKQSRLSRISTYIPVPQPTLAAGNKPEPAKFAISITLLTPGLPIPYSAPKPSESNPYPKPQFVGGLHPGSQNERGSVAGAVAPYMPLTNSENETIAAYIYFDGRAKEEVATLLRPGEETWVNSRWVQVPDSEGGGLAEREFLFREVGLERWLNGLDLKGHDAAEKLEKRRQKFERRRRRQAATLQGNSSTNADGRKSTLRYGDEASPIEPVYDDSDSWSDDDDEPPEATGQIKVAMFRVLASGEIKKGEYSPQFDAHDGDDEYENGNGIDADVEHTTSFAKPKTLDPKTISTQTVTGIDGPDKPYATFTFFYRGERQLQKIGVLQSAKNNPQATALAAKRRSGQIDFSNLGPLKAGGTVGFSAFRDQGAEEARRRKARKKSNGNAADDSDEEEEESEFLGKLEEVADKETSTKLAPEDVKFQGELADGVNRIHLKRAHSADADANSTPETSQRTDSPADPAFLAPPNSSLQPNFDSLAAAMVGSPLKKARPSAEQSNIGDRFSAAHGLSAALGSAVSSKPGSPDKEVAAASKPESKADEEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C897</accession>
    <name>A0A2T4C897_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1400733</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C897"/>
    <dbReference type="STRING" id="983965.A0A2T4C897"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB77791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="386" mass="42394" checksum="28CB601D774FB234" modified="2018-07-18" version="1">MPLPAPTPVSRCALRTTRAIPRCRPARFLGPVAATRRAPFMMRPSIGMPQAAAARPFSTAMRLRMAAEDESFDPATIERESDQVDVCIIGAGPAGLSAAIRLKQLANEAGNEDFRVLVLEKAGEVGAHILSGAVIQPSAINELIPDWLDESNPSRFEHATPAGTDKMRFLTKTAAIPIPAPPQMNNHGNYIVSLNQFVKWLGERAEEVGVELYPGFAAAEVLYNADGSVKGVATNDLGIGRDGRPKDSFERGMEFHARVTMFGEGCHGSLTKKVVGKFDLRRDSRRNCGVSRTGTNHEEDQPVHLQVKDWDAHTDKAYPPFKGLENRFCPAGVYEYVEDESKPHGVRFQINAQNCIHCKTCDIKAPQQDINWQVPQGGEGPKYYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8F5</accession>
    <name>A0A2T4C8F5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1224036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8F5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="20008" checksum="F726546089F2DF14" modified="2018-07-18" version="1">MLRVWSLIWYWVMGLFFFFTSTIHLHQNLFQDSFLLVTAFYSCGSRNLTIEQRGGRYPEIGGFDQTSGVGTFGGKTLRSRPLSLASPTAGSSARTTGQLLELERFDGHSLVTCPPPFAKFSWNLPVIRIQRHFDDDDFSKRPSPVTPSDYPPIRDLWMLPCLSASAPTTPLCLGWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8J6</accession>
    <name>A0A2T4C8J6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1331341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8J6"/>
    <dbReference type="OrthoDB" id="4892796at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="34942" checksum="BA66433C89DB3850" modified="2018-07-18" version="1">MADSPAKFSIRDTLDPGMMSTYMHNQRHALDYLVAKGHITINKTPVIRLNEHGLLCADGDEDVPEETLRQEPRLFQAGADAAVQEATPSSLLDSLLGAKPLKRMSTRESYSTVISIMDSLPISTHVAWRALGAELRATRAHERPKLALQESLQNACEEDDLDWRAFEFFKRACEDGPKFINIQQSLKTLYRLIGVQDEWFFCHKYAYGEAQLRDAEIADAIFLVLGILEHIQGPAFEESVGIYRRLREKCRHLENLLFKTRVAPKLRRFMELYIHRADGNDIKAEDDDERQANPQPKKKRRCAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Y4</accession>
    <name>A0A2T4C8Y4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1421694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Y4"/>
    <dbReference type="STRING" id="983965.A0A2T4C8Y4"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="244"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="557" mass="64217" checksum="6CC7E60FE136ACC8" modified="2018-07-18" version="1">MAGQLGYGELIRKQFTAQKLFFHFLFWTFHFGIFAYGWWKQAADDRLAGLNTLKYSVWISRGAGLVLSVDCMLILLPVCRTIMRWIRPKIRFLPLDENLWMHRQLAYSMLFFAICHTSAHYVNFYNVEKRQIRPVTALQIHYAQPGGITGHVMLLCMLLMYTTAHARIRQQSFETFWYTHHLFIPFFLALYTHTVGCFVRDTADGISPFAGEQYWSHCIGYLGWRWELFTGGFYLIERLYREVRARRETKITRVIRHPYDVVEIQFNKPSFKYKAGQWLFLQVPSISKYQWHPFTITSCPFDPYVSVHVRQVGDFTKQLGDALGAGAAQAKFYDGVDPMGMYEVALQNGQQMPALRIDGPYGAPAEDVFENEIAVLIGTGIGVTPWASILKNIWHLRNSPNPPTRLRRVEFIWVCKDTGSFEWFQTLLSSLEEQSNEAARVPGSSGVEFLKIHTYLTQRLDMDTAQNIVLNSVGADMDPLTELKSRTQFGRPNFSRLFRTMRDGILDRTYLGGLEGSMKTTVGVYFCGPSVAARDIKTACKAATAREVEFRFWKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9H7</accession>
    <name>A0A2T4C9H7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9H7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="16726" checksum="AEAC41EDCFF0A807" modified="2018-07-18" version="1">MAATAGTISLSEEQASLPIHSRPEKDRNRHAIHSPDKWNFMETADEKSCLYLTFTEGDTSPTATMHVVGRVDICPVCLLLTPFSVHGQEKKMKENKEFAMKHLVSLSSLQDYAFRCIHEGSHKLLKLPAVTRLVISSRGGGDTRVPDQHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9M6</accession>
    <name>A0A2T4C9M6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1420406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9M6"/>
    <dbReference type="STRING" id="983965.A0A2T4C9M6"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="99426" checksum="2AB529179976D391" modified="2018-07-18" version="1">MLSPHARRPRVRFILLIIFASVTSYYLLFSGPTPRFNIVPYHSGAPEPKGDQALPSGAPQAPSATKDKDSGVESNPGSAPVSNDIPAKDESEDKSSETPAKDEDDGSIQNGKPSAEEKQHDDHPGNDAPKNEPSELPSDAEKEQKPLNMDLETYNKEVEMLESWDMTIDDLRKWKDPDDKENYDDVAPGYETDGQGRDSGTISRLQHEKDMRKMWRYAYKTTANLESSNKIYGNTLSTLDFKENRTESLQRKLKEGSEVTVDFSVDKPVRFNPYPDYNSDEWKKLKHAPHVTCKGPTGEPVEDLLVFKGRPHDFPEPKFGSYALFDMDPNICWERETRLGPYGLLEQTKKVGGEVEVIDWDNVNWGDLVRRCVESNAARFDLTKEKKNPYLDVYPGLVKPAAPKDEGSKSGEAKGAPDEKKEKESSAAPVNLDDKTTKVKGRSPAESGAEENKYVKEKRSAILLRSYTGKVYTKNDKETIRAMISELSLKSGGEMEVFLLVQVKDNKLNPFEDREVYQDILQKHIPPEFHGITVLWNDQQVWDIYTELKDDNERSVHTAQWLSVQKFSQDHPEYDFIWNWEMDFRFTGHHYEMLDSIGKFAAKQPRRGAWERSDRFYIPEYHGDYDTTFRKDIEEAYAGDTVWGAPELPFITPVGPKPPVKTAEEDNYTWGVGEDADYIALGPIFDPVNSNWIIRDNVWGYSDATHRARDLPRRTTIVTHSRLSKRLLDIMHVENLRGNHVASEMTPQTVALLHGFKAIFAPHPVFTDRDWNGKFLQSWFNPGPRGESGGYGSPFGWGRERRFQGHSWYYRAEPPNRMYNNWMGWVDTDIGGEAWEKEHGRPCLPSILLHPVKDTKPTKEGHKTGFELFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Z7</accession>
    <name>A0A2T4C9Z7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1399551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Z7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9Z7"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015616590" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="12642" checksum="7D653BA33B84F71D" modified="2018-07-18" version="1" fragment="single">MRSLFTLATFVAAAQALYFYIDGGTPKCFYEELPKDTLVVGHYSAEEWDDRANMWQEHQGISIYITVDGSERPNSETSPSRQTPASSAGSSSSSSSSAQPAPGSCPICAHSSSSRSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA13</accession>
    <name>A0A2T4CA13_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1461547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA13"/>
    <dbReference type="STRING" id="983965.A0A2T4CA13"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000015">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB78409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="721" mass="80696" checksum="8CE497FB93102FC0" modified="2018-07-18" version="1">MDRQSVYSTRVYESNFGDAEDTRLQLQSQLETFILDFRIDNNFVYRDQLKENVLLKKYYCDVDIKDLISFNEELAHKLVTEPAEIIPLFEAALKKCTHRVVFPHEKTIHLPDHQLLLHSDADDVSIRNLDSMTIARMVRVPGIVIGASVMSSKATELHIQCRNCSHSQALPILGGFTGVTLPRQCARKRIPHDPTPQCPLDPYFVVHEKCRFVDQQVIKLQEAPDQVPVGELPRHVLITADRYLTNRVVPGSRCTVMGIFSIYQNKASKNSSTGGAVAIRTPYLRAVGIQTDIDQAAKGNATFSEEEEQEFLELSRRPDLYNIMADCIAPSIYGNRDIKKAILCLLLGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKAAPISIYTSGKGSSAAGLTASVQRDQSTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTILNARTSVLAAANPIFGRYDDMKTPGENIDFQTTILSRFDMIFIVKDEHSREKDERMAKHVMGIHMDGRGAEDVAESEIPIQKMRRYITYCKTRCAPRLSPEAAEKLSSHFVSIRRQVHAAEIEANTRSSIPITVRQLEAIVRITESLAKLTLSPIATEAHVDEAIRLFLCSTMDAVNQGSNQGSREMNDEVSRLEAELKRRLPIGWSTSLATLRREMVEGKGYSEQALNRALMLLQRRDTIMFRNQGAQVYRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAC1</accession>
    <name>A0A2T4CAC1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_2984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAC1"/>
    <dbReference type="STRING" id="983965.A0A2T4CAC1"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF13">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="488" mass="55390" checksum="62BEF25EA2C064DA" modified="2018-07-18" version="1">MAPKQEVFHLHPHGWENDPERETFEVSTLDYLTAMSYNNWCLFFKMDDAMKPRAVEILKEGLERTLAQARYLCCTIEKKESGSGHEYVKTKDSTVRLFVQYLDAPEDADKYPSMEDIEKANFSAVTLGDLKLWSVEPMTYGEKPEAHPDAHPVVAAFKMNFVRGGLVLIEHSHHYAADVMGFAGYTRQLAENCFAAFHKTEFPSWDPKAMDLSMLCKPEPPEDQKIDGPPAPQRHPDHVQGVCLLFHLPKSKAAELKKMAQPEEGQQWISTYDAFVAYIWRSITRIRAPVFNPDPASKPFLCEAVDMRRRFTNPKVPPRIRGNVMFAALSTTAPVEAPTVAQVMSEWPLSRLAQYIRALTNSVTQESLDKTLEMVATIKDKTSLNIRIDSLPPMSVLFTDHRDAIMSTSDFGFGRPITYRHLTDRVTEGVILVYPPRSSDPASDEGPEFSFFYEKRLAQDLIEDKEFSKYFEYRGVDAEDATAQALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAL4</accession>
    <name>A0A2T4CAL4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1399750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAL4"/>
    <dbReference type="STRING" id="983965.A0A2T4CAL4"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000051">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="161"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="37528" checksum="E8622B88276A7560" modified="2018-07-18" version="1">MAVTADIPLIDISGDQDAVAQQLVDAAHEHGFIYIRNLGADISPESIDGAFALSKKLFDAPLAEKQACTIQTNNRGWSGMHSETLDPKHQKIGDFKEAFNFGEFIDGKAQQPLPPTIAGDEPQISAFADSCHRLCRKLLHLLGIGLGVGDFFSSAHSTNGESSSILRLLRYPPPEQTSRSSEDVRAGAHSDYGSITLLFRLKGQAGLELQKKDGSWAPVPVCPPGTENDPSPPILINIGDLLSYWTNGLFRSTVHRVVFPAEDGGSGVEGESSAGPRYSIAFFCHPRGAVPLEPVPSDRVRNYVPDESAPNENPYAERKVMTANEHLFMRLKASYGTLYDEKKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAN3</accession>
    <name>A0A2T4CAN3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1352241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAN3"/>
    <dbReference type="STRING" id="983965.A0A2T4CAN3"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="236" mass="26741" checksum="8369FC0CEE5ECC20" modified="2018-07-18" version="1">MKVNEKIAISTSRVLLVPYEAHHVLTYHDWMQDPAIQEATASEPMTLEEEYENQQSWRTSHDKLTFIVCEPLSGEQQSVAAQEDDSPDKMRGDINFFLYLDDDDDEEVSGSSREGKTIRLRGEVDIMIAKTQHRGKGLGEAAVRSILGYIRRHLSNILSEYAKGEGLSEEKVQLVGLMAKIKEDNAGSRALFKKLGFRQEGEANYFGEVKMVMNWEGSVIEGLGEGLEYRELEYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAU3</accession>
    <name>A0A2T4CAU3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSCRP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1437539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAU3"/>
    <dbReference type="OrthoDB" id="4873607at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754747" description="SSCRP protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="6760" checksum="32A90A008C414FFC" modified="2018-07-18" version="1">MKVYAALLALTAALASACNTCNDCPGDQVCNHFGGFGVDPTTFCVEPNDPSCNDPRGNCDTLTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBG8</accession>
    <name>A0A2T4CBG8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBG8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="65" mass="7148" checksum="1655949F7E32F7B0" modified="2018-07-18" version="1">MMSAVPDQHRRKENIASRKQQKASESKQSRASPSLPLPIPRPLTPTRLLPVFMSQPPLSAQTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCE6</accession>
    <name>A0A2T4CCE6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small regulatory subunit of acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1326522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCE6"/>
    <dbReference type="STRING" id="983965.A0A2T4CCE6"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="79"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="311" mass="34007" checksum="4FECE65439C2A5E2" modified="2018-07-18" version="1">MASLRPWSASLRLAAVARTTVRHSSSSSSTSAIAYKALRRRSAPLPITDTPPAWSAQAAVSNILYETPTPSMAPPKRHILNCLVQNEPGVLSRLSGILAARGFNIDSLVVCNTEVEDLSRMTIVLTGQDGVVEQARRQLEDLVPVWAVLDYSNAALVQRELLLAKVNILGPEYFEELLAHHREMSNGESASETGNEYERTLEDSANDFHPSKLAASEALRHKHEHLKTITYFTHQFGGKVLDISTTSCIVEVSAKPSRIDSFMKLVAPFGILESARTGLMALPRSPLHKHNEEAIVKEADEVVDASQLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCF8</accession>
    <name>A0A2T4CCF8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1389275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCF8"/>
    <dbReference type="STRING" id="983965.A0A2T4CCF8"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="219" mass="24531" checksum="FF89CEACC1D7B891" modified="2018-07-18" version="1">MRSLGERLNLLRKRLISIKCGPGAAVLPADVTRIHMDFAIHLKGGHMGARKFWKEYLPRLKYHNPAIPMIVNRHDQNQNPPTMTIYLRNKPSSSTAEPSSSTSSSSSSAEQAIAAAQPASSRTGLSKAQPPTPDERVVHIDMTNKHSSHILEFFMAETRAVPLQPTNEEIAEMQALETLRRNAEVDRERMRLLREEKKREEDMLKRARAAGGMADAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD53</accession>
    <name>A0A2T4CD53_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1419827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD53"/>
    <dbReference type="STRING" id="983965.A0A2T4CD53"/>
    <dbReference type="OrthoDB" id="5431149at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015567519" description="MARVEL domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="46955" checksum="10F7A0B60C2A70E6" modified="2018-07-18" version="1">MPRIFSLALGALALVTTTATLCTQIAVSVRISHSSPGKGSSTAAAVFEAALLILIGWLIAADTFPSFPGQSKLWRGVVSGLEVTACIIATATSLAALVYLARADGGENKHLLVASSVTLGLAVSTQLVYSIYQVLPISSDGSGASWPGRKDEETGRSRKINLKAIRYSQTMPIVDEPSPMAKLHTRSRPTSVDNKSVAETVASSVTYVAQSIRSVSSRPKTRSSKEKERSRSMSIDSTANRSTMADDAFDSWDTSTVDAHNREAVLEISSPTQSKPRGLETIPASPVPSRSPSPASFADLEPPRIQTRRRSRSYSPVSITRELRDLPTPGSSGSEAHIHPLFRSDSPDPHPFATPGTIVMAAPETARVLVHRPSSLSLNRLRSDSMPSSPMSFGRHDFDSRSLRGNRSELDLSQQGFPFPDRGMAPPAPEWLRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDP7</accession>
    <name>A0A2T4CDP7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_64627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDP7"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR VIB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="100"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="100"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="628" mass="67693" checksum="619DA7503EF0ED6A" modified="2018-07-18" version="1">MTDLRGEPAHSSFWSTYNGSAHLANRLGTTTMDSGFHSSASASPLPGRPRSGHEQPYPYGRYSQEDSAAYDRHPQPSLPAQHGYSGLKRPFSQTEPAAYQEIVQDLREDGSRLTVNQDHKLLAFRRTQDKHTIVDQQGRVQQLELSAQLHGMFFLSEMPSTASDGTALQPELTCYRRNLFQISGSLITPRGQLSVVNESNETLPVTSMEVAISAIESVDGNPVRLIVIPWKTPPPNAPEINQSPDQEPAALPLIPFQDDGTEPDGDYAVYPIGWRRLQFRIATANNGRRKELQQHFVLHLKVFGTLSDNSKVVLTESTTAPIVVRGRSPRNFQARKEIPLLGSSAGSRGQALVETGLGVVAGALSVKPQELKRSVDIQVPRSSFTFSSPKVPGSGQLSSLRSNQYSAWSASSSNTSIPQVGSSGTGSYPAATMGTDTYSKVSISGASNYTSDPHEMPLQSSIPPLPLSMGASEQPSSARGQYTYMQQPASGSQLPASTSTPAVASHADSALSVPRYVDNGRPNKSPRQSGQQSVHGGNSISSSESPEYRYGSSTQGSASSREYYPPSQAWSTTTAGESTSSTAYASTDPRPYPFPHEPYKPGAAAGSSVKTESRASFEPMHNYSWHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE88</accession>
    <name>A0A2T4CE88_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE88"/>
    <dbReference type="STRING" id="983965.A0A2T4CE88"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase C-terminal" evidence="7">
        <location>
            <begin position="94"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="227" mass="24567" checksum="43A14520AE130FAA" modified="2018-07-18" version="1">MSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSVPGLKVVSPWSAEDAKGLLKAAIRDPNPVVVLENELMYGQSFPMSEAAQKDDFVLPFGKAKIERAGSDLTIVSLSRCVGQSLVAAENLKKNYGVEAEVINLRSIKPLDLDSIVQSIKKTHRLLVVESGYPAFGVGAEILALAMEYAFDYLDGPAQRVTGAEVPTPYAQKLEEMSFPNEQLIEQFAAKMLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEI7</accession>
    <name>A0A2T4CEI7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1435697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEI7"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015581371" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="135" mass="14504" checksum="9C49C90240E87507" modified="2018-07-18" version="1">MVSFKSIAVVVGLAASASAAAIDSSLVEKRASCVYTCGSVCYWQSDIDDALAKGYSLYKSGDDEDSYPHQYNDYEGFSFPTAAPWYEFPILSSFKVYTGGSPGPDRVIFDSKGNFDSVITHTGASGDDFVACKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEJ1</accession>
    <name>A0A2T4CEJ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1418662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEJ1"/>
    <dbReference type="STRING" id="983965.A0A2T4CEJ1"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="62"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="307" mass="34841" checksum="F962AF309817CC85" modified="2018-07-18" version="1">MPPSQRRRRPVDEDEDMEENPRPRQRQHIEASDAEQDDEASDDDAETNSASTSVDDQMAKKLVRYAISCEYSRTAIRRDGIKERVLGKQGRSFRRVFALAQTQLRTIWGMELRELPVREKTTLHEKRQAMKSNAQPKSGSGAYILTSTLPDAFRSASILAPSKVPSAEQEATYSAFYTMVVSFIWLNGGELSEQKLQRYLTRLNADRMVSSERTEVVLKRMERQGYVMKKVDRPPVGYDGDQTISWHVGPRAKEEIGLDGVMGLVREVYGQPDDDAFDKKLRSSLGIKNRPLAERGEEEHGDVGMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF15</accession>
    <name>A0A2T4CF15_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1435840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF15"/>
    <dbReference type="STRING" id="983965.A0A2T4CF15"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="632" mass="69233" checksum="FC97CAEFA4F23DA9" modified="2018-07-18" version="1">MDKHQDILSFLLTSKQSYALYGETLHRHNIRHGGCSVLEWAARAKNMALAMKTLETPKIEEHALKELWTNVLQIAVSNNNLDLLRLLFELETVQTNIKQASDNKLVTGLDMPITLNIDTQFLRPMFDAADRGMQEIVDLYLSHGASIHLFDWTRLTALHYAVSSNRLALARHLLDNHGANPDDFGSKRPIMTAARNGYSSMVELLLSRGAEPNANVNGTPFSLALMDAVVEGNGDVVSVLLKDARVDPNARNASDMLQLLLDDGQADPTQRNPLNRTAMDLVIERNETEMARMILADGRVNPNARTLNGETALENAVRSASHAIVRILLADERVDPNSTVLDGMTPFLFAADAGSDFCLKILLADKRVNKYARNNAGANAWTIAFRRPGNRNAKVLLESGIMNPNAVDGNLKTPSMLAACLPATLFLELFIADERVNLNMADGNGHTALMLAVQHDRPGNVALLLDSDRVQVNKQSKHGETALMMAVSLKRVWIARLLLASPRINVNLGDRNGVTALALAYAMASVDLAEMILDTGKVEFGKAARPEESEGVDARLVSFKSEIETRSARYLDAMVQVYARVDQLNAGDRDGLTMLEAAIELNDKYTVGLLLGTGKVAVTPKALECADDAIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFR4</accession>
    <name>A0A2T4CFR4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_46638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFR4"/>
    <dbReference type="STRING" id="983965.A0A2T4CFR4"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="713" mass="79586" checksum="AFEA47FBF9E7B7E8" modified="2018-07-18" version="1">MPALSLDKLRSTQGKVAELRLELNSGGKKDKNYATKKIALKRIVANMTMSNNDMVALFPDIIQCMHISSLEIKKMCFLYLVNYARVRPEIAVNAIPILEHDMEDSNPLVRALALRTMSYIHVREFVAATVPLVKHMLRDSDPYVRKTAAFCVAKLYDHDRHMVEQSDLIDRLNSLLRDDNPTVVASALAGLMDIWERSDAIKLTIDYTNASKMVAILPDCSEWGQTYILEALMSYVPQESGEASLLAERIAPRLSHSNSSVVLTCIRVMLYLMNYIADQKQISALCKKLSPPLVTLLAKGPEVQYLALRNALLILQRRPEVLRNDIRVFFCKYNDPIYVKVTKLELIFMLANEKNIDEVLTELREYATEIDVHFVRKAVRAIGKLAIKIEPAARRCIDLLLELVATKVTYIVQEATVVIRNIFRKYPNQYESIIGTLCEHLDSLDEPEAKAAMVWVIGQYADRIENSDALLEDFLYSFQEEPVEVQLALLTATVKLFIQRPTKGQELVPKVLKWATEETDNPDLRDRAYMYWRLLSTDMNAAKNIVMGEKPPITAESERLESSTLEEMCLNVGTLATVYLKPVQSVFRSARPRKLIPSPALQKQYAANDLDNQKSLSMFGNGTQPTNIDLRTRNAAAAPAPNGGNLAQAVNDADAYFSSVGTQQMAAMRIDGGEDGYGGGGGNVTGYVVNALAPQAVLQPAHGEGSNGDLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG02</accession>
    <name>A0A2T4CG02_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1324593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG02"/>
    <dbReference type="STRING" id="983965.A0A2T4CG02"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="117"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="471" mass="52873" checksum="3C15579C9E62FFCD" modified="2018-07-18" version="1">MSTTENAIRAHPPREAPEELRQQRPQQPAGAYFPLGYKEAAYQWWCGVTPSMAERNVLQHIPFLKEATASMGSLSNTDAGDPYGTRIWRRSMVQLSGKNRALNEFSIERVGEETEETLVMLHGYGAGLGFFYKNFEPISRIAGLKLYALDMLGMGNSSRPSFKIHAKDREGKVIEAENWFIDALEEWRKARKIERFTLLGHSLGGYLAVSYALKYPGHLKKLILASPVGIPEDPYAVNSALPEPGESTMQNEFTVDQQTTTTSKNGAALPPRRPYPNWLVWLWDANVSPFSIVRMAGPLGPRFVSGWTSRRFNHLPAEEAQTLHDYSFSIFKQKGSGEYALAYILAPGAFARRPVINRIQDVGRQPIKGPNGEVVGKETGFPIVFMYGENDWMDVAGGLAAEEKLKQVKANIMRTGTEEDKANENGSCKVVIVPKAGHHLYLDNAEFFNNIMRKEMEDVKEMEKRKRVESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGF0</accession>
    <name>A0A2T4CGF0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1436180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGF0"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="37"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="594" mass="66278" checksum="4230D19ED9606AF5" modified="2018-07-18" version="1">MSTERIKVPPNGLEIKSVLSPITPTIPTTPFTSGFTPLVTVVGFHHARGPEVESWFGVEEGVDPAAKYGWNLLPFMALSDGAHASEEDFSYFTLLRPETDDGPATSLFGISCTRQLDSSQLINRPADVTRSTVQKAVVVIADSPQFFGMLRQRLSIVTQAWFAQREFTDVDILRGFQESLADEKARGILQEEAQRDQYLGMSLRELIHEFKWQALVLLKCCLLQPKMLFFGSRCDRLCMVQFSLISLIPGLIRNLQDCADPELNTYEKKLAQPTSLQSSNRNSLLTFMGLPLQIFGKGSIFGPYTPLQQLDLLADVGTKSYIVGSTNSLLLQQKDRYSDIIINLDDDTINITSPSLRTALSLTAADRRWIDYLTQEVNNTWDESNPSTPKTMQYAGSEEYIRAQFESYIIGLISSVKFHNYLVKNSATGRNTAESDPAVDFGLDWVEAWQRTENYRMWDAHTDTNLFAVSEPRHPCAGGLSIEDVQRRIAEQVKELHLDERLAQGRDILGRNFAAGKEKASTMLNRLYNDMEQMREAQRRRAEENAKLNEANGGSKRNSMASGTSVDTTAAAAAAKPQQETETLVGNGGTKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGJ7</accession>
    <name>A0A2T4CGJ7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGJ7"/>
    <dbReference type="OrthoDB" id="4894549at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="14556" checksum="AECE7FA9A71CD7B7" modified="2018-07-18" version="1">MCEVTRTKYSCRHNTITYTTRCAHASSSLSRCEKKISTATSSEKCPKCSPDSRHKQIADLYATYGVELARLTALARAQECQVMVTQLEGIRRGLAEERTRALVELEERIEGEEGERRRVEEEVSGEGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGN5</accession>
    <name>A0A2T4CGN5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1324399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGN5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGN5"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031221">
        <property type="term" value="P:arabinan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23399">
        <property type="entry name" value="beta-trefoil_ABD_ABFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000131">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000059">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032788771" description="non-reducing end alpha-L-arabinofuranosidase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="12">
        <location>
            <begin position="28"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="11">
        <location>
            <begin position="364"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="413"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="53109" checksum="DC622C2EBA203906" modified="2018-07-18" version="1">MSPRTDRRRSGLLALGLVAASPLAAAGPCDIYASGGTPCVAAHSTTRALYGSYSGSLYQVSRGSDGATTNIGTLSAGGVANAAAQDSFCAGTTCLITIIYDQSGRGNHLTQAPPGGAASGPQPNGYDNLASAIGAPVRLNGQKAYGVFIAPFTGYRNNQPNGTATGDQPQGMYAIFDGTHYNTGCCFDYGNAETNSLDTGNGHMEAIYFGTGDGSGRGTGSGSGPWIMADLENGLFSGYDPINNPADPTINYRFVTAVVKGEPNQWAIRGGDATSGTLSTFYSGQRPANGYNPMSKEGAIILGIGGDNSNRAQGTFYEGVMTSGYPSDSTENAVQANLVAAKYVYDTSLMTSGPALSVGSHISLRATTSCCTNRYIAHTGATVNTQVVSSSSSAALKQQASWTVRTGLGNSACFSFESVDSPGSFIRHSNYQLMVNANDNSKIFHEDATFCPQAGLNGQGNSFRSWSYPTRYWRHFNSLGYIAANGGEHDFDATTLFNDDVSFVVSAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGP8</accession>
    <name>A0A2T4CGP8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1388951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGP8"/>
    <dbReference type="STRING" id="983965.A0A2T4CGP8"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="15534" checksum="9668946CAEACE8BA" modified="2018-07-18" version="1">MSCRQAFDLAWSCNSLGGQWNAVYRHGEMRSCSHLWDDFWFCMRTKSYSGPLKERAIRDHYRRKEYEKYYAPGARSSEDIWEARERKVEPGTAFAEPVEIATVDDNEWRREEEERRRKIRQGLGFEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGR7</accession>
    <name>A0A2T4CGR7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_203254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGR7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18637" checksum="E690255F93F31E9E" modified="2018-07-18" version="1">MRCTPCRATCKPFSPPILFRTTSHGALAPHQAHQEPHTRVRAEVRTVDKSLWNVSRMKRRLWGIPISERRSHLLEGFQASTGTGQRTHTNIRGEALAARCRVLPRTALPFAFCPLPEMRVWYPVLLEKREKLGRSSAVDRGMPRARCTQQQALRMSTPYEHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH62</accession>
    <name>A0A2T4CH62_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1396018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH62"/>
    <dbReference type="STRING" id="983965.A0A2T4CH62"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="271" mass="29214" checksum="2E3DBA9E1F4E11B3" modified="2018-07-18" version="1">MSSFPPDSHAPTPPILPPKPSSQEPSRIGTPTSGAPPPPPSSLSEAGQQYRASVLSSSAAAAAAGATPPLPPPPFPPSSAMRAAEIPDPGDQWLPQVVQDKSKQDIADILSSPSLLNALAHAPQSIHPSLRASHAALSTALSSNIDLATRLLESERRLARQRSATQAQLLSMHALERQWRQKQTDMDTALARFSPAALYQLLAQSVQEQGAVCHALEESFLEDDDAAAGGGTAGEREAADWIRRYREAKVQFYLRQERKERWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHB1</accession>
    <name>A0A2T4CHB1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1387498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHB1"/>
    <dbReference type="STRING" id="983965.A0A2T4CHB1"/>
    <dbReference type="OrthoDB" id="5413466at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="356" mass="38166" checksum="73EAA336C6355171" modified="2018-07-18" version="1">MAAVPRRRKLIGQRRRVEDEGDDEGRPETLELDDDSLTEGSVISDDHDGADDSDTSNIDEVSPTSPNARKSANGTAAGAGRRGSRPGPQGETSKSVSDTEALLRGMSVADPPHAANEVQVDEKPSFQENLPASIPMHQPRPQKNISVADIESPTMTHNAPAFQQAFHQQVPVQMTNGYQDPHARRPSYSAHVSTGTPLSQIPERAIHAAPFQPTTYGQPAYYAGQMYPPHPQPGYYYPHGYSGPGMPASAVTAPPFVPGGQPGMPGSFTPQHPVEQPGVPVTGPPAPPNTNLVAQEVNGMVYYYDASQLPSVNPYQPYPASQPYQPSVMGMGGMVTPSPDGFYYPQPAPGMVYYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHS9</accession>
    <name>A0A2T4CHS9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1396299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHS9"/>
    <dbReference type="STRING" id="983965.A0A2T4CHS9"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="216" mass="25510" checksum="A4306F1BD49ADBAD" modified="2018-07-18" version="1">MMRNQRNSDYRDRSRDRDRERAPRHRGSYGDRERDNRERERDGDRQRDTRDTGRERDGDRYRDHGRTRDYRDRSPDRGGDRYERRQRSRSPRRHASGFRFKGDEPRRRPRENTEKKEPREPKEPKAPKAPKPSTTAGQEMIVVHVNDRLGTKSAIPCLPSDTVGQFKLMIAARIGREAGQIMLRRQGERPFKDHITLEDYGISNGVQLDLEVDTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIH6</accession>
    <name>A0A2T4CIH6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1466897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CIH6"/>
    <dbReference type="OrthoDB" id="2992173at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1351" mass="153042" checksum="6A2094E9B6EFF0A6" modified="2018-07-18" version="1">MASSPLAVPVKLDAFIFNPDTCNGTETNQAKISPLTQPNYSYLQIKNFMLQNDVLHPIELHAAAPAARNSRITDLATGKTRQERLGVYLHWMVPRPYRTGAAATGQESNQSRAQRGLFTSNVATEKEDLATPLFPETPNRWLVIRKIVGNVEPPEAEASLEPVTAWVIESDWMRSIDEMDDTDGTKYDLQVDVSPYLQTGSTEEPTISEQAEVFIGGRIKAKEWNESTSQAKKRISLGVLNSSNQLFPDYMPHNSNVFSMLDSFEYAPSKYATRAVADYYVLGDHSAGTRADRLQALSMALNESDSPVPDDVSEWLKSTESGRILCHGAMYDVRWNLKWDENNRPRVIADEVADQLHMQTPISVGTTPLDSLLSYELLNNLSALLQAQSESIENRRAGADEVQNYNFAKFAGGSRYVFQIDPKNPAAPPSDEAAALLKKLNESQALYDASARQLSRVQWKHFALWWRAAMRQYKEEVQNLDWDWQRLVASLNSQKNAIGTAKNDIQEKLKLELKEAVAPVFSQQRDPTIFVGGVEAGWPTDYLDKLLVRLQSQIAKHTPPPPDEEVNYGLQCIPDALQEMAKSLIGEFLHYEKERLVEESSSEKEETDKNVFPPLYHDEDGRDLWKNTQPWFPLFMEWEAEYYHIDYDKWDMEERATRSTQDKKFRYTVKQDDKPLWESKNDDRRTISGRILLLPQPVFSLVGQVERLFTTVPEDELSPILPKDKREQVLKDLKKLPFVSAPLDGFANHLLTLSEGSHLKPNVRYPGQKPVPMKDAYEDSVVIGLGAVELERMGVETDLTPYGSLVRVGAVTHSIFKPAVHGQFKLTKLNIIDKFGQAAAAIDPKRRHDGPPPIYPCISEYYEPQIYEKNGYPNVVEKPQSKGDCQFMQVPPSINQPARLNMNFVKLDQHDGEYHWRPITEWENPIWGWVLVNYVDFGIQFFLRDGTFYREVRLAAPNNPNKGTQATDKWLPFKPPAELDKVRQLDHLIEQFSGEGGRDYLNGFMDMATQATRNASTVPGAYAQCVNSLIGRPLALVNAGISLELSADARTNQSTVGDQPSKRPPYTLLPDSHPDTKQYEFSIKLGDAARPHDGLVAYFRARDKPLPEDELKLDQLFTSFKPVSPHDKSDRIKPIDTETFVRLKPFWLDPNDYNTQKEPQDKEVEDIDEEDEESKYAPQEKFTIDHNKKLTVVGLLMDPFTPVNAYSSILPVEPLALSTWTWESALKNMTAFFHFGPLMVEKDVPVYNPERILLPNYDLEQLKGQKIEVKLPALAVADWSWLQPYLDPNSTRQASDEDEEATDEVYMALRLGKIDPVPQFAPGPLTALEGFLQMVHPITAPDVGGDKSQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ78</accession>
    <name>A0A2T4CJ78_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ78"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ78"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="484" mass="52308" checksum="09937EE523175B51" modified="2018-07-18" version="1">MADSRELEPPPQTHVEDPGAHQLAEASDSEDQFTDAQSAPASPGVSSPVPKTRVERVNTEPSYGEVPGTEAYKTREQDAEPDEIAMVSDDTPEPSPSAPPEPGSVPVTVVEESTGEYPGQHSAEEQEKHKADATPDIILSPNGEIRSGNEDAIPDAPLSPTSSSARSRRESLASSQPTILAAPHQEAGDDTAEQGQGEDDDFGDDFGDDFDDFEEGGHDDDFDDFEDGFQHAQPAESTTSAPPPNQPQQSLPFSIPDFDGLSPDEVISAIEPCLPSLFPPEELDFPAFQQLPKDSSIFLTPRSASLWSQLVAPPPLAPPDWIRSRTRRLFLVSLGVPVDLDEILPASKQKKLVLPSLNIPATSPRGSSDLRSTTRLKQSDGNASSTSVDSQGKPSTSKRRKGPPPQPELDLVAAKHLCQTTDEALDGMTDQELKQHVAKLEAMQGAAKELLEYWTKRTDEKIGDREAFEGVIENLVAHARKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ86</accession>
    <name>A0A2T4CJ86_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF521-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1396812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ86"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ86"/>
    <dbReference type="OrthoDB" id="2594507at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01355">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="PMDh-L-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="PMDh-S-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577:SF3">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="AcnX_swivel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomevalonate dehydratase small subunit-like" evidence="3">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomevalonate dehydratase large subunit-like" evidence="4">
        <location>
            <begin position="211"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="642" mass="68770" checksum="DE3B040401A881CE" modified="2018-07-18" version="1">MIPKNRQISLQLVVNSTELPQKRSFARSSASDIFSPFDISSKAEAMQLKQSSYKGTAYVQGTASGPLIASKLELSFWGGVDPQTSQVIDHHHPLSGKSLQGTILAIPGGRGSCSGSGVLLELLLSGKGPKALIFSRREDILTLGVVVAEEIFHKSIPVVVLTAGDFEDLLDARYVVVNGRTISTVQLGDAMHNFGDVSTEPLDTVALGFNIELSNRDNAILGGAHGRAAQAAMRIILRMAAIEGSLRLIDITQVHIDGCVYTGPGSLRFAETLRDWGGKVVVPTTLNSISVDQRRWRAQGVPSAFGEAAEKLATAYTDMGALPTFTCAPYLLSSAPERGEQVAWAESNAVVYANSVLGARTMKYPDFLDICIALTGRAPQGGLHIENNRLASLCVELPLFEEGDVDDSFYPLLGYHLGGIAGSRIPVVVGLDVLRPSTDNLKAFGAAFATTASAPMFHIVGVTPEAATLQDAIGEREGVETIRLELEQLEPVWRTLNTAKENAPVDLISLGNPHFSLAEMRRLAGLCRGRIKHDGVAVMVTCGRATYGLADQAGLINELRQFGVEIITDTCWCMIGEPVIPSTASTIMTNSAKYAHYGPGLTGKRFCFGSLERCVDAACDRYYNARVPAFIGTCIAQGSDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJC8</accession>
    <name>A0A2T4CJC8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJC8"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="504" mass="57402" checksum="7D22E26006AB3B97" modified="2018-07-18" version="1">MALLSLTESSQPLDHTTEEPIPLKSRRVHVFFEPVLLLVALIEAVRNTARPRAPDPEINCQDPTELFCAFVNKLSHVCDRKKGGKTVTSFVILGDHEVDPQHAHYVFAMNKQTDSQLQSTRAYVKALLRKVDQAPKGQENQQDARHSLLFHILRFNRPRVMIYMTKLRAQAASCLESCQAEATAENDEIAIVLRDLLDIPESGSDRQDTESEYISNCEATMQLLIRIDRSPAGKLIEDRALEDRIAGYRSMECWAELLHTMRRILAYQQSVQFFLLAKEKWPSLFQNPTVDFLGSSRPVPKPIRNKSLFAENIVGRMTSDPNVMEIFRQFVRDLQAFDLDERLRQEYQRDTFKPTVHAEVLLLDWVWKQSKIAPLSFFINCTYIGSSKPTCKLCDFYFQIHKLKIGHRMSHGNLYSSWRVPDVFPQQGEEALHDRQIMLNGLLDRVRAEAFDLVSKKAVPSAKVDDSLTASARMTLCEVGNLHGSNTDADIDDIASLLGEVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJE3</accession>
    <name>A0A2T4CJE3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1418299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJE3"/>
    <dbReference type="OrthoDB" id="3597048at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="26259" checksum="22689095B853B283" modified="2018-07-18" version="1">MAYFPALCIALGLLMVDAILELAFITSMVAWLHNTASGTFAVNFNGSTFDLYGEPKHFLVDQGHSSNGAAGTAIVLIGFGGIVTLWLRSRPNVFGPRFTSFLYGTWLVILVLGLMLTVGSLGYVFSVTNAHRGQTIDVQVASTTGNHKYPVDTWTPQNWFAAVLKLDLADDSQRSDIDNHLRVMRGWQYNLIPLFLIQLTTTVLAGLEYLERRKHRPSAGEYGSVERNSGEQKYVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJM0</accession>
    <name>A0A2T4CJM0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1321474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJM0"/>
    <dbReference type="STRING" id="983965.A0A2T4CJM0"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="520" mass="58734" checksum="8046A9E01A86F3B6" modified="2018-07-18" version="1">MFSIIVAGVVTVICLFIHHQYYRKKNASLSLPPGPKPLPIVGNIFDLPPPGTPEFQHWLKFKDLYGPISSITVLGQTMIILNDKHSADDILNKLSLKTSSRPKSVFAYELCGFQNFTPGRSYDATFRLHRRFMHQQAGTKAIAAQYHGIHDVESRRLLKRILDDPNNLVQHFKTGTAAMILKIVYGYSIEPKAADPLVELIDEMMSNFSEAMVPSSRLVDLIPALKHLPHWFPGTAYKETARQWKKINHDTVNIPYSFVKRQMASGTHRPSMVSDLIERYTSANPRNGEMDNDKEDAIKWAAGIMYGGGSDTTVAALTSFILAIALFPEAQQRAQEEIDGLIGKHPERLPQFEDQGRLPYTSALVKEVLRWYGIVPISTAHVADEDITYGGYCIPKASYLLPIVWWFHHDPQTYRDPFVFSPERICPGRYISDDNLFITIARILAVFNITEMVDRQGNSIEFQVEYTPGLVSHPAKLPSMLITARSERHEQLICCIEVDHPWEKSDAGLLESEDGLKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJW8</accession>
    <name>A0A2T4CJW8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJW8"/>
    <dbReference type="STRING" id="983965.A0A2T4CJW8"/>
    <dbReference type="OrthoDB" id="5399305at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34915" checksum="6E371587F141DB2D" modified="2018-07-18" version="1">MTATGYIPKNEPVERHEQGVTKSRKTIMTGGGRAWSEAEEQYLVRTRHQKVPYKQIAANLKKTELACRLHYHQLTHSSARRRHSVSTTPSSVSASASSGRPSELMTVTILGPGTHHHHHHRPTGSLSAHRRAESYSSTSTASSSSGDNVQLPRIVDAWASPHALPVILPRPSSMVVDHLPRLHEELCHLPPPPQQYHQSQHHQQQQHMERPAAGFPLPSTATHPPPYVDMARLHALYDVHRDAFWHAIARDYGWNASPAALESAWRDSQRRGAAKAATPERPMTPADSPEAPARRDSVDRTSIASLLADASPGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK62</accession>
    <name>A0A2T4CK62_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1427704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK62"/>
    <dbReference type="STRING" id="983965.A0A2T4CK62"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="2">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="245" mass="26406" checksum="531F1AFCA8E44011" modified="2018-07-18" version="1">MAKKVADALSENVEWMGVRSRAEGSPPVKLLDYACGFGMVSSTLLGHFDIVRGIDISDTSVAGYNEIARKSGIPAEQMLAVQGTIPSTEMDTVLAKEDFSDFDLIAISMALHHIDDRVGVLSGLCERLRSGGVLVVVDLTPEAHSHDHSHSNEQGHSHNHSHAQSHGHDHDHGHDHSAASHTISKHGGFGPEDMKALMVEAGFVAESFDYKPYLDITPVKANTPSHGSCESARLKPFFIAKGVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CKC1</accession>
    <name>A0A2T4CKC1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1027518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CKC1"/>
    <dbReference type="STRING" id="983965.A0A2T4CKC1"/>
    <dbReference type="OrthoDB" id="4885321at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="339" mass="39746" checksum="9D654EBA29F4ABC8" modified="2018-07-18" version="1">MASQKPSLFRFTKSWNESWSKYDSAASSADEDSNYSLLSGDDLQRRKSETQKWPLAISVAVNIILSFGLTLLALRKQSDPALQIYSPVNHLVEYHVTNISTGFMTKTPYMGFPNDEIDRMWEDLYQYGDSAITKEEADRLALPTINERGTDRYLIQLEVFHQLHCLNDIRKAFYPERWPHKWEYNEDGTVNRNTMQFRHWDHCIDILRSTLMCNADVSPITWRLNLPVGAVLAPNLETTHTCRNFSKIVEWARTHEATDLRQEVTQEERQDIIDNPPFDQTAWEDLSGFWAAFPGNTYFRQWQAGWNETEEGRAFWHQWNIEQATEHENLPEFVEPHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP91</accession>
    <name>A0A2T4BP91_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1406781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP91"/>
    <dbReference type="OrthoDB" id="5289641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697:SF1">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24337" checksum="5BBCD624504CF186" modified="2018-07-18" version="1">MLLDILFQAVLIILSIHKGIRKYYSLADQGFPKNPFSIVEKEPNDSSAVLTNCAPETPAATIAEAPGPAVEDEFPDGRRYVVPWPGNKYHIFLDGTDQVICSHDDGKLHLCDADKDDLQLHTWVCVEKDGYFGFFNTHTGKFIGHGNDGWMHSTARYHRDWELITVRRHPEGGYELLMPYWSHTLKKVRVFDGSKTVVLKRYGTTRWQFVKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPD6</accession>
    <name>A0A2T4BPD6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tim17-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1345004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPD6"/>
    <dbReference type="STRING" id="983965.A0A2T4BPD6"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23250" checksum="03F048F23EC138E2" modified="2018-07-18" version="1">MTKSARHEEVFLSARSAPASQPVFPAESHPRLSIMTPTRLLLGSVASSMVGFSLGALQGGQMAQLRFRAEHAHKMPDTTAGWYLYHKSKNYHAMQGGIREGFRMGFKTGIWSLVALSLESTVDRYRGSSDMFSTVIATLTVAGAFSLWHRFSLSTAARTAKYGLVFGLAYGGVQDLVGLARGRPIGYVEMIRRRFGSRSREGDGDASGQQRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPK4</accession>
    <name>A0A2T4BPK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1344699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPK4"/>
    <dbReference type="STRING" id="983965.A0A2T4BPK4"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12467">
        <property type="entry name" value="RRM_Srp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000123">
        <property type="entry name" value="Pre-mRNA splicing factor (Srp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034403">
        <property type="entry name" value="Srp1p_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="193" mass="23058" checksum="E80235FF4F4DE9B5" modified="2018-07-18" version="1">MSRGGTTLYVTGFSHGTRARDLAYEFERYGRLVRCDIPAPRSTSSRLFAFVEYEDRRDADDAYHEMHNKRIGRDDLLKIEWARTPPSASWRFESGRDRDRRGPRSPRRGRSPSPRRSTRDYSPRKEERRDRDRDYDRDSRRDRDRSRSPEHRDRDRDMKDERDDRDRKENGTNGDERKAESPLPAHDDLDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPM5</accession>
    <name>A0A2T4BPM5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1426730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPM5"/>
    <dbReference type="OrthoDB" id="3636394at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32088" checksum="9CDF345EFE665342" modified="2018-07-18" version="1">MSLLRQFIVFGTDSAGLERSLRFLQALVTLIATYPTAQVAALLRLTSISANVPPQASFLQLSSKINLTRRLLRLFRFLEQFKLGWDFYAYGVLDFDTWLDVVGKTCLGIFGMLESVTLLDLLEIDQLEIFGAEQTASLNYQAQYFWLIGLCISLFRSGTRLLHLLGNRKTKSSPSSSRKVGKKEGSQTEGEHQDGREVSSKNGVVTAAKEPDEVHEKGSPRRMEADGGPTASGDTISSLLVKILADALDLLLPATAVGLVQLDSAAIATAMIISTVITANDVWVRCGKGIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPV8</accession>
    <name>A0A2T4BPV8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1473539</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPV8"/>
    <dbReference type="STRING" id="983965.A0A2T4BPV8"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="501" mass="56641" checksum="3B97DABB3F478D2C" modified="2018-07-18" version="1">MAESYPTLTQCALVAAAFKVLLFPAYKSTDFEVHRNWLAITNSLPLSQWYYEKTSEWTLDYPPFFAYFEWLLAHVARLVDLAMVRVYNLGYDSWETVYFQRFSVIVTELLLVYALQMFVDSSPLQSKRAAQVAALSVLLSPGLLIIDHIHFQYNGFMYGILVASLVLARSKSTLLQSGLVFGALLCFKHIYLYLAPAYFVFLLRAYCLSARSIFRIKVLNCVKLGLGLAGIFAAAFGPFALMGQIPQLLSRLFPFSRGLCHAYWAPNVWALYSLADRVLIHFAPKLGLPLKTEALNSVTRGLVGDTAFAVLPEVTPRVCFALTLLFQILPLIKLFKRPTWENFIGAVTLCGYASFLFGWHVHEKAILLVIIPFSLIALRDRRHLGAFRPLIVAGHISLFPLIFTPAEFPIKTIYTVFWLVLFLISLDRMAPASNQPRVFLLDRFSTLYIAVSIPLIAYTSLFHQVILGKRLEFLPLMFTSSYTAIGVVGSWVGYMVVYYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR85</accession>
    <name>A0A2T4BR85_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1385749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR85"/>
    <dbReference type="STRING" id="983965.A0A2T4BR85"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="145"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31622" checksum="E4AA134304FCFE15" modified="2018-07-18" version="1">MAEKFTIYSSSESQWVGVMTLALSEKGLKEHQDYDVHEIRLSTGDNFAPEYLAINPNGTVPSLTAPSLAKPLIESVDILRWIDSRGTRTLVPQDETRSNKIIELMHSPSMSTNLILFQARDAAEMAAKKSSAWNAFLEGRQTRLDKELAAQPDHPFYVSKAAENLSITSLYRSDIGPDHEELFKLSGQMYRTVAEGLDKLEGLIALPYAAGSKVSEADYNTVPWLAHAMMGAETPVTAIHDFGPLERLIQKTVPEFKIGPRTKEWWSNISKTEAFKKVYPVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRE2</accession>
    <name>A0A2T4BRE2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1395371</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRE2"/>
    <dbReference type="STRING" id="983965.A0A2T4BRE2"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015375887" description="Extracellular metalloproteinase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="284" mass="30705" checksum="E6B6417BC1F858C2" modified="2018-07-18" version="1">MKSAILLGLTGLAATVHAHPTKQHDSGSNLARRGIDISKYHLPSLSDYTPSTHVDVEDEASLQSVDLKRDYVATATRAVKRLAPHAEFRVVDDHYVDVDGIGHVHFKQTVHGIDIDNADFKVNVTGSTNYPMGAWADNNPAGIRQYPYSTSLTTNPLTYKSVNSQTEVHSAGTTWATILYEVLWALIDKHGKNDAEFPTFDSQGVPTDGKFLALKLVLNGLALQPCTPTFVSARDAIIDADRALTGGENVCELWTAFAKRGLGSGAKYSSSSRTESFTVPSGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRN7</accession>
    <name>A0A2T4BRN7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1426093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRN7"/>
    <dbReference type="STRING" id="983965.A0A2T4BRN7"/>
    <dbReference type="OrthoDB" id="10338893at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="86" mass="9612" checksum="F0B6B7FA2D745781" modified="2018-07-18" version="1" fragment="single">MDHPGATISLASITNPRARSRSRDGRFIDEPRNSRQSFASRESSYVYPEEDLDGRPVSRRSTHNGPGGSGGHLPYPDDDRLQYLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRS4</accession>
    <name>A0A2T4BRS4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1465969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRS4"/>
    <dbReference type="STRING" id="983965.A0A2T4BRS4"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="285"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1134" mass="124600" checksum="117FF00AC52257BC" modified="2018-07-18" version="1">MFSNLSNIVQRAQQLIDPTQGLNLSNSDRNPSKASLFQSQFRLPSSQTPLYEINAELTIPPSNSTRGDPDHDRGWHYAGKLHLSEAYLCFSTTPTSFTPSASTSTSSAFTGQTNGSGPSGSGFTWPLCAIRRVERLNSQNFQFALAITTWNGLLADVAKPKDANNNSTNKDVREQRITIHLAGTRQACERFCDGLKRGLRAGVGNVGKLRKVVAECYSEHLLRTDDRAGVSPPDAGLGMIFRYPGDPKKLRDRAKMRLWAEYLRDNGRNMMLIRQPTFHKLIRVGLPNRLRGEIWEVTSGSLYLRLENPTLYTDTLAKFKGQESLAIDEIEKDLNRSLPEYPGYQSEEGIGRLRRVLTAYSWVNADVGYCQAMNIVVAALLIYMSESQAFFLLSALCDRLVPGYYSTTMYGTLLDQKVFESLVEKTMPILWDHLVKSDVQLSVVSLPWFLSLYINSMPLVFAFRVLDVFFVEGPKVLFQVGLAILRINGEELLDAADDGAFISVLKSYFARLDESAHPKSENPKLRAVTRFQELMVVAFKEFAGVTHSSITELRLKKKDAVLSNIESFAKRTAIRNLGPDSKLLSPEELGSLYDRFYNVLYERQQRGKMIQEELQRQAKSSRLRGSDNYPTAAPNEVEKGRVGLGPSTSLMDYDAFREFLAGMSRWAISDASANGSDNKPYVSRKTSNALSPWGNGPEPAEHEFLQRLFRKWDVDGASALTLQNVVTGLAGIKGKRDIMGTITYFFELYDDDNDGKVDREGILRISEALLFLSRRGLEGSLSPGASTAGLNGDGMSASDSQSSLPADISNAERFLGSVSAFIRRCFEYADPDHPKNQDGSAFGTLGSNDEMIDPNAFAIGDDEDDDDEDEDLLTMDTSPTATPTKAKKPADLLSPDDSSLPDQSGENESRRRVSKAKAEAANAALDPAHPLYITLPTFRMVVLADELLEQFFESSFPASLHILEGLQSASSSSYASSLTTFSNLGFNTRSQTQAQSGPMGGGRGLRGVLDNIVTDGMRVASEVRRRMEEAQRELEKNALPSQRTEEDEEDDDDVGVAIGVRRGTGGASADIERRSVMSADRDLLDGVDAEVGSGASAKESGESSNLLDVDAAAGRRRANSASTTGGPGVLEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS21</accession>
    <name>A0A2T4BS21_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">R3H domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1098714</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS21"/>
    <dbReference type="STRING" id="983965.A0A2T4BS21"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="179"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="325"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="262"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="500"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB72085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="66273" checksum="4C72F82CDDBB5578" modified="2018-07-18" version="1">MAQQPHDMSYLDYGTAPNRSPSSSRQNYANFPSGLTMPRQTQRPFDAPLPSNALYSTERLASSYGGRAMDNVGAPSSMPTYMMDNNQSWSYNGSGVATVGGAVHGPGRQRSVNRRAALPTMQNWTEHGGMGMPNLQSYSNGLGAAAMANGGLRVDGPGSHPSPNSLQSGGNDADQLIPTAIVIKNIPFAVRKETLASIMLEMHLPQPYAFNYHFDNGVFRGLAFANFQSADDTRLVIDAMNGMDVHGRKLRVEYKKMLPEAERERIEREKRERRGQLEEQHRAPLLHNQSSIQSLGGMSQAQARTASAAAGPPTSSLLGDIDMNDPQTLEFYTELAMFRRDDSREILVFPPGIAPEHRRCIHILAHHMGLEHQSIGEADSRQLTVLKRQQPSPTANLQTPPASSLDVHKRGLSRAATFDFAADRESRTASSTYGHLVGRHGPTLELPGSPDGSGIPNNLRAAKSFADLRSFTPSPSQASSSYLAPGSGLSSIAPTSTARFGDYLSNGGQSQSGNPSTPGKNDNGLVSGLSGLSLSPFEASSLQSQARNTPGAIGSQRPSANGNGIKNIPERQPRNPEWEASNGFGRTRANGHMQRGSDSSDNGARVGSSSTNASRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSA5</accession>
    <name>A0A2T4BSA5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1434064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSA5"/>
    <dbReference type="STRING" id="983965.A0A2T4BSA5"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="215"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="423"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="588" mass="63124" checksum="9E94B174E323B17D" modified="2018-07-18" version="1">MYSASFAFFEAIWDAGVTHCFVNLGSDHPGMIEAMVKGQREAKTGFPRIITCPSEVSGLFTMVAMSMADGYARVTGKPQCVIVHVDVGTQALGVAVHNASSGHAPVLVFAGMSPFTQEGELRGSRTEFIHWLQDVPDQKAILGQYCKYAAEIRTGVNIKQMVNRALQFSRTAPQGPVYLCAAREVMEAEIKPYSIKQEEWEPVELGGLSSKSASRIAKSLAGSKRPLIVTGYSGRNHGVPKILIELADTVKSLRVLDTGASDMCFPGDHPAWLGVKQGADDSIPNADVILVLDCDVPWIPTRSKPSPDALIYHIDADPLKQRIPLFYIESEGRFLADSLTAITQILEDLRTGEASKTLATKDQSAAEEARRQSYAAKIERIAKAAEPFADNTFGTGHLSKVLRSVCPEDTIWAIEAVTNTGFIHDNLRPTLPGSWINCGGGGLGWSGGGALGIKLAADTEGKGQFVCQIVGDGTYLFSMPSSVYWISRRYGIPILTIVLNNNGWNAPRKSYMLVHPEGVAAAATNEDMNISFNPPPDYAGIAAAAGMGDIFGLKAAKADELEAVLRDAVAKVKAGKTTVVDCSIVTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSI7</accession>
    <name>A0A2T4BSI7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1405634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSI7"/>
    <dbReference type="STRING" id="983965.A0A2T4BSI7"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="38"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="607"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="694" mass="78565" checksum="676631BB0F982784" modified="2018-07-18" version="1">MTAGKMTAVGGIQEMDNPERLKYFGVIDDLRGLGVNEELPLPQIVVVGDQSSGKSSLLEGLTGLSFPIASDLCTRFATQIVLQRTPGGKAAVKASIVPGASSRDDEEQKRRLLEFDTQMDADELSGPKFASILNKAAEYMGLPTSDNQDNEDLEKRFSDDILRIEISGPDEHHLSVVDVPGLFHNPTKFQTREDLTIIRKLIEDYTTDERTIILAVMDARNNLANQEVFKMARAADPAGIRTVGIITKCDALQSGDEQGVLKIAQNSVERLQHGWFVVRNRSTKEILEGVTIPQRHENEKRFFQQAPWNELPRDRVGVKALKPFLGQLLYEHIRREFPALMREIEDLVRETEREVKELGAPRQTAADQRQYLTRLASRYQRNVEDALKGNYAADLDTKSPLKLRMHLRDLADQFEEDLRSKGHTSPFQHPDGSVDKDYLNEDAESEAPDIREWIQERYRDARGAELPGMVNPTLLVNLFREQTIQWERIAGDYLEQVIQLVTKYSELESRRTEADETIRASLDSKILAQIEITKASAKQRLVNLLQDERGGILQTVNHYFAETLAKLRQDRVIARLQALGLRDDQPCMMDLAKLTSTIHLSNEDQAVNDIHDALKAYYKVAIKRFGDYVVISVVERFIGDQGALKFFSSEYVGGLSDQQLAAMAAESYATSTARVELEHRCQRYREALRVARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSV6</accession>
    <name>A0A2T4BSV6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1465529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSV6"/>
    <dbReference type="OrthoDB" id="4900101at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29752" checksum="33B137EC693B5416" modified="2018-07-18" version="1">MFAFLFEERQTDERTGPIEDNHADDEWTWGPAIDNPQPPTPTGNTSRADDREYLAIVIDHEVLVEELVHSRWWLDKPLDLTEPLLRIRDPESSSSFVAESGYLEIDKHSWIQTSSYNEVASLQRLESHTDTSDSPLAQKNARAAEKPVITSKYFGSDGAEGHASLLLAPTIEDLEFQRDFQDKKADVDCLVTSMALSAFGVNYHANCSHGIIVKSPRNMNTLSEVERFDSAIRIYMYPTNIQVREYNLEHMERRGMPLIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTF3</accession>
    <name>A0A2T4BTF3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1394450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTF3"/>
    <dbReference type="STRING" id="983965.A0A2T4BTF3"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:carboxypeptidase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
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        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ArgE/DapE_CS"/>
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        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
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        <property type="entry name" value="Pept_M20A"/>
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        <property type="entry name" value="Peptidase_M20"/>
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        <property type="entry name" value="Peptidase_M20_dimer"/>
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    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015705491" evidence="6">
        <location>
            <begin position="19"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="196"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="457" mass="51452" checksum="F1E41CB9DCA8BF75" modified="2018-07-18" version="1">MVATKKVLLAGMFGLSAAYNISPMSSLSRLFNKFPLGYGHNNADMSRFSCDLGKPLDPSDDGLYSSHDLFSTEETIKTLVERHQPLVKIESICYDDLGDFEDDRWGPFYDIPKVLENKSPTVYDKAWVETVNRFGLVYTIKGSDTSLKPILLTAHQDVVPVANETLDSWEHPPFDAFYNETTGYLYGRGASDDKSAITALMSAMEALLSQEDYKPRRTVVFAFGFDEECSGPRGKIIRNGPIHEALICFTRYSPYVLPELTYYVNMGMLDQAAHSLAQVQRETQYFIQTSQAVDWIAGGQKINSLPEFTTLGINHRYAPQDSIGSIQHRIVKLVQGVANKYNLTVQAFEGDDDYEDYLRSIGHGPQHGAVWDVFAGTVRHTFADQAKKVVPAPGAMTGNTDTRHYLNLSENIYRWSPGSLKSFSNIHSVNEKLLMSEHVNMVKFYYDFIRNFDQADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTV2</accession>
    <name>A0A2T4BTV2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1362941</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTV2"/>
    <dbReference type="STRING" id="983965.A0A2T4BTV2"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="39"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="203"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="489"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="594"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="701"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1079"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB72740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1230" mass="137303" checksum="B37EC6ED3C430EFB" modified="2018-07-18" version="1">MAPSATSTEWDHQFHTLRRQDLFRNPPKDHSAYPALQQAVNPHIEAFNAIFRGDGKPGLLAHGLEDIGTKVFLDGNDRSAPEGRNKLHIRIKDVTLQKPQVPPSNKLAVNREIYPAECRERHATYRGKLSATFEYSINGGDAIEFTRELGQVPIMIKSNRCHLEGNSPALLVSRKEESEELGGYFIVNGNEKIIRLLQVNKRNFPMAINRPSFTNRGAGYTTYGIILRSVRPDETSQTNVLHYLKDGNVTFRFSWRKNEYLIPVIMILKALVETNDREIFEGLIGPMGSKAASNTFLTDRVELLLRTYKAYRLYSKSETRAYLGQKFRVVLGVPETMSDYEVGTEFLRRIVCVHLGNVNVTEKQDLDKFHLVLFMIRKLYALAAGECAVDNPDAIQNQEILLGGFLYAQILKERLDEFLGTSVRAAIRDYLRRHPTVNFMSEEFRKEFPGGIFRKSNENIANGLEYFLSTGNLVSASGLDLQQTAGFTVVAEKLNFLRFISHFRMVHRGAFFAQLKTTAVRKLLPESWGFMCPVHTPDGSPCGLLNHFAHKCKVMTDYVDVSSIPALVAELGAVETSSASTDESVVVMLDGKILGWCTPKESLRIGDCLRYWKVEGSHNVPLELEVGYVPPSHGGSYPGLYLTSTPSRMVRPVKYLPLQKEDYVGPHEQPYMSIAVVPQEIESGVSTHVEFDPTNMLSILANMTPFSDFNQSPRNMYQCQMGKQTMGTPGTAIRHRTDNKSYRIQTGQTPIVRAPLHNTYGFDNFPNGMNAVVAVISYTGYDMDDAMIINKSAHERGFGHGTVYKTKKITLKDDSRTRAAKSVVKMFGFAPHSFVSASHQAMLDDDGLPHVGRMVQEGDVLCAYHTVTPDYNGNLVNLDGITHYEKYKDSEIGFIEEVRLIGAESGSEPLQTISIKIRIPRSPVIGDKFSSRHGQKGVLSQKWPAVDMPFSETGIQPDVIINPHAFPSRMTIGMFVESLAGKAGALHGLAQDSTPFRFDEENTAADYFGHQLMKAGFNYHGNEPMYSGITGEELGADIYIGVVYYQRLRHMVNDKYQVRTTGPVVPTTGQPIKGRKRGGGIRVGEMERDALLAHGTAFLLQDRLLNCSDYTRSWICRRCGSFLSVQPVVSQFAPGKKKAPSMVRCRNCAVKLDDSEGIDLTEIQGEIWEDGQGHCWVGGDETTQVVVPGALKFLDVELAAMGVKLKYRIDKSDEPRKGPMKPLKQITAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTY6</accession>
    <name>A0A2T4BTY6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1083670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTY6"/>
    <dbReference type="STRING" id="983965.A0A2T4BTY6"/>
    <dbReference type="OrthoDB" id="4900327at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36197" checksum="C3C4A947C8E0F7DD" modified="2018-07-18" version="1">MMWRLRVASFAFAGILFGGHVLANGVYISRPTIEEPVTVTSYVIIYDGTLTEITSEYESTSTTETTTSTATEVSVTETETETTTSTTTEASATETGTETYSSIPSTSSSSFSSVHTTFTTSTKGQITTSSITSTRVPSSTASSLGNKYPEDHTSSSPASHSTRVNAAQIAGIALGSGAFFCLVAALFFFFFGRRDAGRSARGDGNRRLSMRDVGAGLGAVKTRFETAWGKETMSEMKQRQERMEEVQGPAELSASELAVELPAELPAELPAAVMNLVGDRKGDASAERETGGFRPPVVKELDGASVISHKPTSPSSEQQQEQQIQQQREDSQRQSQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUB4</accession>
    <name>A0A2T4BUB4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_154753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUB4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17497" checksum="C5220A4F672474A0" modified="2018-07-18" version="1">MHKVKESGAMPALTGQQQGLVTARASIPCPRSRSNRGPCIRKPNSTWQKTSFSSPARQPGIISWGQDTQGGCQGSWLVARQDLCATSREEVRAQERRLPTPAADRREEASAVIGRQLCKRRKTGCYSRCTMMLRTPQFFSSFGRDSCRALKPINAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUF7</accession>
    <name>A0A2T4BUF7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1472761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUF7"/>
    <dbReference type="STRING" id="983965.A0A2T4BUF7"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="376"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="549" mass="63252" checksum="89C30DE88C018F1A" modified="2018-07-18" version="1">MAHSKTITTQNDSRNAKDSDSRMTCHNRSRISAGTPRTYQQEQDAIKQSLLSEINAAKAEQDSDSDSEDEDGFIKRKEPAQTDSNGVHPSRAKAVKLSEVDVNNADKDPETFLSNFMAARAWVPEEGSRWEAFESDDGETDDRAEEFEQAYNLRFEDPEKSNEVLKSYARDFAAARSVRREEKTGRKRQRELEREKKEAEKQQRREDKARLRKLKLEETEAKLQKIKQAAGAFGKELTDEQWMKFLDDAWENDKWEDEMKKWFDEEYYAINEANAASEDEDAMDVDGQDKKSSKKKAKPKKPKWDDDIDIKDIIPDFEDEEKPKITLTDDEPQDDDNDEAEDDDDEEEPAAKKRKSSDHKRAKQESQKKARQERSKLEALVDAKLQLTDHDVLKKQEKEAASAGGFRYRETSPQAFGLTARDILLAPSDKVLNEYAGLKKLATFRDVEKKRKDRKMLGKKARLRQWRREVFGGEYESTGPTYGFERLVGAEEEEEHHKKKTKKRSKDKGKEKSKDGEKEGASNIIGDVDGTRKKRKRSKGKKGKTESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUI4</accession>
    <name>A0A2T4BUI4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1068938</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUI4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUI4"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="469"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="340"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB72967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116766" checksum="A12975C35071ABDE" modified="2018-07-18" version="1">MAPKKKGNKNAQEDWEAELGESIAPAPAAPENNGDNAQEEEESAGGGGLMAMLRKNKEKRKKKGIVDDEPAPAPVEEDLSAKAPVEASLDDDEFALPQKKGKGGKGKPAPAAAAKEAKDDLEEPGRILTKAEKEKLKKEREKQRKKEQAAKKKTPAPAKAAEPAKATPAKEEPAAEKPASPAAAPAAAETGGKKKKIPAHLALIQKQQEELRRQQEEAARLEAEARAQAEEEEKRLAEEAKRREEQRAIKKQKEKERIEQLKKEGKFLTKAQKEEKARNELKLQQMLAAGIKIGPQEEEGAPKKKVVYDSKKKRGKNDKDEEAALAEAAERARIQAEKALKEAEEKAAKEKAEAEAKAKAAKAAQLSDVEDDWEAAVDGEEEDVKDSWDADSDEEAEKKAAAKANGADKEKKAGGSEGESESESESEEESEDEAVSRAKQLEAQRKKEAAERREKAHQAALAARSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVDAIKQKTAVVNKNNDFEFKVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEPQTLESMRMLRERKTPFIVALNKIDRLYGWKKVDNNGFQDSLALQSKAVQNEFKNRLEQTKLAFAEQGFNSELFYQNKSMAKYVSLVPTSAHTGEGIPDMLKLIIQLTQERMVGSLMYLSEVQATVLEVKAIEGFGMTIDVILSNGILREGDRIVLCGTEGAIVTNIRALLTPAPLRELRLKSAYVHNKEVKAALGVKISAPNLEGAIAGSRLMVVGPDDDEDEIVDEVESDLANLLSRVETSGRGVSVQASTLGSLEALLDFLKDCKIPVANVGIGPVYKRDVMQCGIMLEKAPDYAVMLCFDVKVDKEAQAYADDQGIKIFQADIIYHLFDNFTKHMEEMLEKKKEESKMLAVFPCVLKPVAVFNKTAPIVIGVDVVEGQLKINTPIAAVKTNPTTGAKEVIPLGRVTSIERDHKQVPVCKKGQPSVAVKIEMGGHQPIYGRHLEETDLLYSQISRASIDTLKEYYRKEVTNDEWQLIIKLKPLFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUV6</accession>
    <name>A0A2T4BUV6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1297625</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUV6"/>
    <dbReference type="STRING" id="983965.A0A2T4BUV6"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB73087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="87" mass="9481" checksum="2391115E6864E19E" modified="2018-07-18" version="1" fragment="single">MAQPHTGGLLSPPELSPLEQEVLEEYDRLATNMKTLATLLDDLASNPTVGILDGLRELERKTSLAFTLLKASVYSIVLQQEIDWGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVF8</accession>
    <name>A0A2T4BVF8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ORP1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1382303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVF8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVF8"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="60000" checksum="3620D1548B76AF51" modified="2018-07-18" version="1">MGEAPLDASMAPLDGEPRCMFVDNCQTGSQLRKAISHLFGRNKACTLRIPKQVWVYYCRKHYQRIRYRNAKTYPLNQMYLVKMQINRLQRWSDENQRRGVGPYIKMWTLALRKREQSRLDQETGAADEGGGDNAPETTTGSAAPGWIIERLGSEYTTKDMLAVADQLYTEIENGILGQVPEVEFLPDITESEAGNTAKLVKSRKQGRIIAAPVEAKTYKRRMSDTTDAIDHRGSLLPNQYDGVGSAALSRKRVCGSSPEAGHYRPPLQVPLPSITNYANNRVPASAVDDQSVMPRALPAVPKLQMQMPPPSRSQGPVAHMYGPSSSEFRRSYAPSGLYNHDHQQQYPAQYRMGAESPLQRNRDVHNQLRLPSISAHLAGTSNTQDSNLAMPWGLVSDGTNIPRPPRLRSYSDNVSSIQPILDYSRPVSSSGAPQPGLMCSEDRGSIPSTNAPDYRGYPQGHWPESTSASGWAQRPGTRQQIHYYDQVTRPGLDSLRAANNQGPVRLRSAAEGGEDAAHRYGNTWLPTEQSASKAAREGRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVQ5</accession>
    <name>A0A2T4BVQ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1424714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVQ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVQ5"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="514" mass="56980" checksum="9C491D222301D2F8" modified="2018-07-18" version="1">MDPQDETISPIPVDPTQTWHDSNEKQGQDREHGLYEEPNVALPATINAAYDWTGPDDPDNPRNFSASLRVFSTIAITMLAMIGTVAGSMYAPAQDAVASAFHCSRIVAVLPLSLYNLGLAFGPMVGAPLSETYGRKSVFLISTPVFVLFMLGSGFSRSVAGLIVCRFFAGVFASPLINNAPATLLDFTPPRYRGVSLGGYYAVPSFGAALGPLIGGFVLLAKPWQWTQWISIFITVAFYIPVCFTRETYKKVILKRRATRLGLRDSASQRTSPGRAFRYFFTTLIQRPLHMLFTEPIVTLVSVYNGFLFGLLYTFVVSVPWIFRHYYGWPVESEPLSYLGLMCGTAAAAAPLIVIDLRYYQKRLTEWQTTSHEEDEPLPSENRLMPALIGSVMLPVCLFVVGWTVHFRVHWMVPIVFQGLVMLSSLLVYAGANLFMLDAYGPLYGASASGAMMFSRYLLSAAFPLFALRMYEALGAGWATSVLGFVTLVMAPIPWFFRVFGGRLRGRSKYEMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVY9</accession>
    <name>A0A2T4BVY9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1441098</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVY9"/>
    <dbReference type="STRING" id="983965.A0A2T4BVY9"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB73478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21856" checksum="33902FF4E8B7AC02" modified="2018-07-18" version="1">MRLAPPTSHVSREVSFEYLNRQLVWHAFTEFLLFVLPLIGINRWRRWLSRTWRKTKEIINTKQGGDSANGEYGFLPERTCAICYQDQNAAASSESEIMAAAASSGVIGSAQTDVTNPYEAIPCGCIYCFVCIATRLDREEGEGWTCLRCGEHVKECKPWNGDVLEPSRKSTSTKTVAFSDDDEKARSIEQSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW06</accession>
    <name>A0A2T4BW06_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1361595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW06"/>
    <dbReference type="STRING" id="983965.A0A2T4BW06"/>
    <dbReference type="OrthoDB" id="5412288at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019622">
        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
        <property type="entry name" value="RRN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrn9" evidence="2">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-domain containing protein second zinc finger" evidence="3">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="641" mass="72615" checksum="E12D9E66F1F61644" modified="2018-07-18" version="1">MDRSDTEWDLDSDEIASVASQDLHESRPNRWTGPRREWQRFTVEERRLWQSMQAVENQDLAIHLYNAHALKRRGKDPQTAQDVTVATEDGQQRIWAPPRVWTAWPLNERRVPKQRIIERDHDKFDRFTFRKAERHMPSSELHEELGATILRFAGERFRKSLEKSRRKTVLTSIEGDAASQSHAEGSRENEATSSLLEPPSPTQRSNPEDVKMKTYSEDEGGGPIKAEERKKADEVQEPVMSANDDLSYEILRPAVRHILSQLDSTLRILHNARVATTNYASDSSATSDSESDTHSGPKRKRGRPRSTHLTGAEASGHSDATVKPKASKRGRPRKVRIPNEGETYEEMLVRIARESHRRLPMTAKERDAAFEEWLRQGEERLAREEALLREEEELGIDPQASAQERRLRRLGLRDWSDVVGAAALAGFSHQVIARTAKRCANLFGEGMVMRRLDELPASRAPAFHTMEYRPEKIELGGDSESDSEADVATALSSRQPSLGRLSSRGRSSSRGRASPHPSSSAFGTPGKRSQSNSRSRSRSRSSAGFHFCPVPTCERSATGFTRRQNLRRHMQLVHPGRGDEEEEWDSEDEVLGAVHVDGFLKPIVPARGWRERVAASSLVIRKRGRERRSGEDEDDDDDYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWK6</accession>
    <name>A0A2T4BWK6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1360454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWK6"/>
    <dbReference type="STRING" id="983965.A0A2T4BWK6"/>
    <dbReference type="OrthoDB" id="4338954at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="116" mass="13356" checksum="E50DB42B75BE8F90" modified="2018-07-18" version="1" fragment="single">MNPVTRRFSTAARVHPSILPHLHASPRRAPFRRWLKTAVVVSAVVYASKSYLDFTRYSSTHSHSSPSHHSHAKDIRAAIQEQDNESLRRQRMMEDLYGGRESLEDLEKGVAEYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWR8</accession>
    <name>A0A2T4BWR8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1404665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWR8"/>
    <dbReference type="STRING" id="983965.A0A2T4BWR8"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="237" mass="26235" checksum="FDAC034D0740F740" modified="2018-07-18" version="1">MANELYHYSVVSSLMEGIGDSGIPYKALIHHGDHGLGTFRRMAGEMICLDGSVYQMKSDGSIVAIDPSAGTDVAPFAMVTRFRPTLTTGITFSNKQDLSDVMTKLFPKTKNHYLAFRIDGTFSKIAVRTADGQKYKHEKLRELHKRQTTYEFTNIRGSLIGFRSPEFLQGVSVAGDHLHFISDERDRGGHVLDCAADGEVQFSGAVMSTIHLQLPEDDEYNEAELTLDSEGIRVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX66</accession>
    <name>A0A2T4BX66_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1404052</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX66"/>
    <dbReference type="STRING" id="983965.A0A2T4BX66"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB73854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="14982" checksum="339EFEEFE67B2F4C" modified="2018-07-18" version="1">MFRTAVLRTSASAVRAVARPVAIRRTAAAAFAAPRAAAPLRVQSFMGVRMYSAGGGLNKEEVEGRIMSLLQGFDKVNDAANIKPNAHFANDLGLDSLDTVEVVMAIEEEFSIEIPDKDADSIHSIDKAVEYILNQPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXD0</accession>
    <name>A0A2T4BXD0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1404182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXD0"/>
    <dbReference type="STRING" id="983965.A0A2T4BXD0"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="245"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="635" mass="68377" checksum="FBF69681D35EC77C" modified="2018-07-18" version="1">MSEPDLVGAVGSPNSADSVHRQAAILDRHLPEGYSADPEVSLANGPVEVPVEPIVGSASASQRGFFDSPAAASAAELGRSNSNSNGNGNGNGNNGSSDATPTLETLESSLKLQGGDIHRDMFKIKAKAGSLRRSNTFSHRRSPDLSPTGELTHSEQLEPGGFRRQHLLRRARQRRQSGMIVANTFVDFLDLYGSFAGEALDDTDDDESAVTDEAEEPADERRPLLARPSAGRRRSSRRLARPGDASTVKTFFTLLKAFIGTGILFLPKAFRNGGILFSSLALISVSLVNCFCFRLLLDCRHKYGGGYGDIGEAVVGPRFRSLILASIAISQLGFVCSGIIFTAENLFSFLDAVTHGLGHFGVSGLITLQFLPLIPLAWIRNISKLGPVALVADAFILIGLVYIWYFDIRSLARHGMEPSVKLFNPSDFPLTLGSAIFTFEGIGLILPIQSSMKKPHQFKGLLYFVMLLITAIFTSVGALCYATFGEKTKIQIISNFPQDSPFVNAVQFLYSLAVLAGEPVQLFPAIRILETSIFGERATGKKSAAIKWKKNGLRALTIAACIGVAVVGASDLDKFVALTGSFACIPLVYMYPAFLHFKGVAETRWEKGLDAVTMVVGAIAMVYTTSVIVLQWIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXD3</accession>
    <name>A0A2T4BXD3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="11">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="14" type="ORF">M440DRAFT_1382112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXD3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXD3"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB74000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="57013" checksum="176B76C75D371503" modified="2018-07-18" version="1">MADTKIVVVGAGPVGSLAALYAAKRGYQVEVYELRPDLRDPSIVPLNFTKSINLALSERGINAMKQSGEPSLVDHVMSATIPMRGRMIHGQSPDGSLYEHSQNYDVNGRAINAIDRGTLNARLLDILDALPNVKLFFNHKLTGADFRANKAWLEARDKDVAANGRPREIEITFDLMIGADGAHSAVRYHLMKFTRMDYQQEYIDTLWCEFHLPPRAVVGEDEKDPNVRFRISPNHLHIWPGRDFMFIAIPSIDGSFTCTLFIPSADIAELERDPSTVPAFFDKHFPGVTALIPPPDLINSFTTNPHLPLISLKCKPYHHGSSSVIIGDAAHAMVPFYGQGMNAGMEDVRILFSILDKHARLEETNKPEDNDDDGELVDSAATAAFQRGLALAEYSAVRAPDAHAINDLALQNYVEMRSSVLSRRYRLRKFLEEFMSVHFPSFGWQTKYSRVSFGNEGYAEVVRKSDRQGQMLVRSFIGLVSSPVVLTALVLAYRRRGSVFSFVGRLFGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY09</accession>
    <name>A0A2T4BY09_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_110903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY09"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="135" mass="14858" checksum="6591B136B3DA4C4D" modified="2018-07-18" version="1">MCLYANVYANVLPPNPTRAADAPPVPRALDQKLQVVCRLHAQDAVNGVAVTHTSPHAATTPVLFFFSLLLCPLAPLLRPPRRKWAPCPFFSLLLRLLLVPVSCVYAVACNMTGFWLPPATKTALCFSDPRRREGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY79</accession>
    <name>A0A2T4BY79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1337938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY79"/>
    <dbReference type="OrthoDB" id="4900365at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="289" mass="33823" checksum="7C4A2EA08E2260F0" modified="2018-07-18" version="1" fragment="single">PPKMHLIKQSRRILSDIFHARQDSNPTPTSHRSKASRSRRRRLRRRTSSPLAVARGTMARFLCKGEKRKRESLDDGHDDEWEFVPCKKRLVGGGLAQGEGVGEEHTELGDVVRCVNDIPYSQPYRYEDSGEEPDELPDDYEELLGKVHSSLENLTITDTHNSPPSSRASTHQTHTDIDCVWLQDIHDWENRYRARRCHSETSTRILPYANAVTGELPDGSGRRLRINWRGDQRNIWMHMWKKEKRLQWEQSWEMQTLKLSFRQRHGRGLMPRHCKQNQADSKKLKEQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYG7</accession>
    <name>A0A2T4BYG7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1338107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYG7"/>
    <dbReference type="STRING" id="983965.A0A2T4BYG7"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="899"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="899"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="970" mass="108528" checksum="C0613CF2CEA48355" modified="2018-07-18" version="1">MARKTTPASNSMTDDGNDDFGLSNQNRGDGTDLGGKTKSDSSAAPPAWSELKTKAGKDRKRLPLACIACRRKKIRCSGEKPACKHCMRSRIPCVYKVTTRKAAPRTDYMAMLDKRLKRMEERIIKILPKTEQDTISSIPRAVVKPAIPGTGTMASGKASVKKRNVDEAFGRDLEAWAKAPRPKLPEDNLAETPESREAAENELLREGREALPPKDVQEHLAEVFFDNVYGQCYHLLHKPSYMRKLKNDALPPVLVLSVCAIAARFTSSPKFNSATKQFMRGEEWASHAREICTKRYDWPNITILTCLLILGMHEFGTCHGGRAWALGGQAIRMAFALHLHRDLEYDPQSRNKKIKLSFIDREIRRRVMWACFIMDRFNSSGTDRPVFIKEESIKIPLPVAEKYFQFDIPVRTEYLDGSLPPACEPTQQGHLDTPRDNMGASAYIIRCVSIWGRIVTYLNQGGREQDPYPMWNESSEYAKLVRDTEELLRSLPENLQCTHESLEIHRAESTAKYLLYLHMAIQQNFIFLHQAAVSFSKDRVDEEAPEDFVSQASIKTFAAANRISDLIRDAEEVQCSIATPFAGYCAFSSATIHITGIFSGDPALKARSEANSSVNVRFLRNMMKYWGMFHWMVENIRIQFRNALDAARMGDQRNGSTASSPILQYADWFNRYPHGVADTDYMDPAVYRKKERGEDGALEQKPELQSIEDFFMTVGPVLNDKDGSRPGPSKRKAPLKKPATGDQQSATMSGQQLHEQMRLAMQRQQQQQQQQQQQQQQQQHSRQPPRFSDALGIHANNPPAFNPLTVSQPQNSTYPNMPTISPANAAQYAQSMPLQNFFSTDLLSMNLEQPSDMMNSLGKLSYNEFSMGAASVVMNGSGGWGNMSGRNPQATPQVHNQQNMKAGGMSSDQAHGQDQMGNNGLNPYLGQDASPGWFLSLEGGQDMGFGSVDPFANLFGSDGGMLMADHQGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYI2</accession>
    <name>A0A2T4BYI2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1381243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYI2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYI2"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="375" mass="41622" checksum="6732E912D708E175" modified="2018-07-18" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAIARVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTAAQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGLSDRMQKEITALAPSTMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYZ8</accession>
    <name>A0A2T4BYZ8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYZ8"/>
    <dbReference type="STRING" id="983965.A0A2T4BYZ8"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="109" mass="12065" checksum="1C609F2A10B79385" modified="2018-07-18" version="1">MSVTHIVLVAFKPDAQPEAIDKFCSTLMALKDTCLHAVTKKPYIKSLTGGINRSQEGHSDGLTHGFIFELESEEDRQYFVHQDPAHLALYDLAGAVEKFTLLAFVPGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ36</accession>
    <name>A0A2T4BZ36_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_56903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ36"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ36"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="374" mass="40212" checksum="40785A93EDA27EEF" modified="2018-07-18" version="1">MPEDIDTSLLERLQALRGSSSGASPAVDYRFSVDVIERSKPATREDALAARLKSLRAADDGSTVSPKREKALTATAPQALPSPSTSHPAEAKDVAHSEQSATLENDEDVDLIFSTDDQTLEELLGDVSPDETTPTPAQDPSDEQVRALLEELSRAVPKDDDAGEGDTAEDSDDSDGERMQAKVSDVVAQFQDEAAVDAALRSSKDDDEAASVQEDQSQDQRDGDADIALPSLPPNLDDLSSFSPRRASTTTTKADDIEDITARIAALRAPAGEEDASFSLPSVPSSRPSAGDKPVRRLTSKTDYTDDDIDGWCTVCLDDATLQCLGCDDDPYCTRCWRDMHIGPAAAFDDRSHKAVQFTRARKKDKQQKVALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZI9</accession>
    <name>A0A2T4BZI9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1380277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZI9"/>
    <dbReference type="SMR" id="A0A2T4BZI9"/>
    <dbReference type="STRING" id="983965.A0A2T4BZI9"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015517590" evidence="4">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="14274" checksum="63E3E974EB9D7AEB" modified="2018-07-18" version="1">MQLSNLFKLAFFAAAATADTVSYDTGYDDGSRSLTAVSCSDGPNGLITRYHWQTQGQIPKFPYIGGAAAVGGWNSAACGTCWKLSYSGHSIYVLAIDHSAAGFNIALDAMNALTGGQAVQLGRVDATATQVAVSNCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZU4</accession>
    <name>A0A2T4BZU4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1380482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZU4"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="249" mass="27655" checksum="38AF829E5EFA10C7" modified="2018-07-18" version="1">MSPPNHLIIVCCHGIWTGGPSNGTNEDEWLIADFQRGETATFIEHIKAGLRCLAEDHDNAVLAFSGGPTRQETELSEAQSYANIASSNNFFNIIPSTNNLSNKILIEDRALDSYHNILFSLTLFYTRFHVWPTHLTIISHAFKKPRLIDGHCAAIRFPHDRTRFVGIDPPGMTTGEKVDGMKGVGQAVDDWTRDPHGRGEVLAGKRRRRNPWGVWQGVFVEEGVDKGGLVTEGEAEAETLVDGAPRPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C126</accession>
    <name>A0A2T4C126_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_20411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C126"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="12729" checksum="5B2BD00FA8A01D92" modified="2018-07-18" version="1">MNAGNNDILEHKEQTPNCWNMICSWLRGFIVTVSIPMSLTSTFCFYNWVFDHFPFDLRIGPSSSGSLAMATCAWVPGVLESVNMNEATRAVTCTPSQWDSSPSIFRQFSNFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1B0</accession>
    <name>A0A2T4C1B0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_55453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2960375at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="83"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="278" mass="31329" checksum="54CEA841F7C45EEB" modified="2018-07-18" version="1">MVPLLEAPDLSYAHEPGHVRSVSETLAQRGILKVSLGFADPKSRYLKQLLRSLHQRHGHQLPISHSATRGWFWDVLPSSTSFQTAHCQARSETMDDFPWHTDCSYEDPPPRYFALQVLRPDRCGGGTLSVMNVERLSGLLSPEARAALARPEFQVRTPPEFVKDARQGDIVASILLADDEGRLTRMRYRDDLLTPLSERAAAALAELRQVLLQGGAEAKGGRSMARLDLTPEVLPEGSIIMIDNRRWLHARNHVRDPRRHLRRVRWDAVPFAGVTVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1L8</accession>
    <name>A0A2T4C1L8_TRILO</name>
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        <submittedName>
            <fullName evidence="5">Dehydroquinate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1358530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1L8"/>
    <dbReference type="STRING" id="983965.A0A2T4C1L8"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF105">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="165"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="357" mass="38349" checksum="AD5B8C7CF0E38726" modified="2018-07-18" version="1">MPSFEYNENSQRVLFGQNSLSKLPSELARLGCSKPLILTTPTKTFYVENVATLLNGQIAGSFSRVTMHTPTEVTEDALKHCMSVDADCLVSIGGGSAVGLGKALFVRTGLPHITVPTTYSGSEMTPIVGQTENRVKTTHVDPKAIPAVVIYDVNLTLTLPAKISATSGLNAMAHAVEALYAQDGNPIASMFAIKGIQTLARSLPRVMQNPKDVDARSDALLGAWFCGKCLAGVGVSLHHKLCHVLGGTFNLPHAETHAIILPHVLAYLAPSIPNEMKVLAENIPDSEGNAVNGLNKLLSKLGITYSLKDLGMKEEDIDLAVTNLLQKSFWSPRPLDGDLLRKLLRRAWEGKPAQIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Q0</accession>
    <name>A0A2T4C1Q0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1274596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Q0"/>
    <dbReference type="STRING" id="983965.A0A2T4C1Q0"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015395363" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="111"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="30555" checksum="D3D8747334A04959" modified="2018-07-18" version="1">MRPTATLMRLALCLSSAAPLVSAWPGWLPELDALVVRADKEGNTAEPTLPGNTAKPTPTDSPQSSQTGDSSDDSSSSKKGGSKTTDKDDKKKTTSKKASKTTEHKQFDPESPPGSVVMQTPGVFDRSAALYKIGDYITWGWNYTHVLGTPTAIDVLISCSTASETWTLTSNMTWKTSVAYTWDSSVQETSVESPLPVAMYTLIIKDSDASISDVPDAGYLGTFSSFTFGLYTPQPYTPFPEWRCDACNAALSKFDHQVLGFAITMGLVTVLSFTWFVSGLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C219</accession>
    <name>A0A2T4C219_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotrophy-associated secreted protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1463322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C219"/>
    <dbReference type="OrthoDB" id="2132010at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015432471" description="Biotrophy-associated secreted protein 2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="27569" checksum="9C8D37B23E2686DC" modified="2018-07-18" version="1">MVRLSVAALLACSLSVYALGDPAGAKNVGNGNGGQFIGGECLSSKDCASTCCAFISGGGVCSGIGAQFQAGKSGCGFGDGGAAPAPSAPAQSSGSNNANTGSTGSSVNVPAGFNTAVGDPAGVKNLGNGAGQQFITGICLTDADCASGCCAGLNGGAVCSGVGAQFQNGKTGCGFPSTSSASDSNNAAAPAPAASPAPAPAQGSSSAPASAPAGFNTAVGDPAGVKNLGNGAGQQFITGICLSDADCASGCCAALNGGAVCSGVGAQFQNGKTGCGFSAKKRSVPAPRVARSFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C253</accession>
    <name>A0A2T4C253_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_19925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C253"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1173"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="724"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="728"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB75639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1279" mass="140772" checksum="CFDCD50830821AC8" modified="2018-07-18" version="1">MSTTPDDYLEKVYAGVLGKLIGVYVGRPFEGWTHQQIIEQLGHIRGYVHDKVGDPLVVTDDDVSGTFQFVRALEEHGYSPNILPEQIGKTWLNNVIENRTIFWWGGRGMSTEHTAFLNLKRGIPAPLSGAIQTNGKTVAEQIGAQIFIDGWAMVAPGNPNLAAKLARAAASVSHDGEAVYAAQLWAAMEAEAFVSRDINHLLDVGLSFIPGMSLVARVIGRVRTWVAEDGDWTKTRQRIEDEYGYDKFHGICHVIPNHAIMIMTVLYASDDFDEAMHIINTCGWDTDCNSGNVGCLVAIMLGLSAFEGPFDWRGPLADRALISSADGGYSINNAARISYNIANVGRRLAGHEELEPPKGGAQFHFSLPGSTQGFQLSWPSDIERGASATLQQRVDISHGPGLAIDVENLGEEQGQLEALTPTFTPKEVLQMKTYELMASPLVYPGQTVTAKIRPSGVGEVVVGLRLKVYSQHDDLVTVDGPSSVLTPGEEHPLTWTVPDEMDSQPIQKIGIVISSGTSSSFSGTIWLDSLSWTGVPNMVIRPPLQKPCEFWHRAWVNGVDTFSSWAFIIAQGQGEGIIIHGTRELANYCVTVPNFMIKFGGPAGLAIRVQGLNRYYALFFAADRRRIALVKALDEERIELTSMEFSWELDRNYRVTLSASGDVIRARVDDVELQAVDGQYGGGGIGLVATDGSAQLHSSALPALTGLNLQFAIAWMAKMGEAEKYRQGDPQQQFQTPGQSQYQGQYQNQYQTQAPYNAGYGDNNNNGYNPGAPPYNPAYNNSQQPVNGQYQDHPYGPPPPYSFNPPQPNDEKYSFDDAFKLEKPKYNDLWAGLLFLLAFAGFVAISGIAIHGYSSGFHGDGIYGDLNGFSLNSNTIILFAFCLVIAFVFSYGYVWLARIFPKQFIWITGILNLAWALGTAIYYLIKGYWSAGIVFLIFAVFLIFAFWTWIGRIPFSALMLKTSIDVSKKHGHVYIVSLSGGLVATALAAWFSVTLVAIYVSYEPSPDNPRCSVSGNNCSHGKVIGLVVYVTFAMFWISEWLKNTIHTIIAGVYGSWYFSPHNFPKKATRGAARRALTYSFGSICFGSLIVAFIQFLKQVCSVARSQGANEGGAGGWIAYAIFCILTCLISIIEWVVEFVNRYAFCHIALYGKAYIASAKDTWRMIKDRGIDALVNDCLVGPVLSFGAIFIGYACALFAYLYLLETDPPYNRDGGFTAVVMAYAFLIGFQIAHIFTTPLGSGIDTIFVAAGWDPQVMMRDHPELYHEMVRVYPRVQQAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2J5</accession>
    <name>A0A2T4C2J5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1261456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2J5"/>
    <dbReference type="STRING" id="983965.A0A2T4C2J5"/>
    <dbReference type="OrthoDB" id="5369511at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="350" mass="39667" checksum="519A6CC250EFE1AF" modified="2018-07-18" version="1">MSPENMAQPGFAYNMPSASNGHWNPPRSLFAEPYNSGRLAGNLYPLSSINLSTSAYPWADSPPAPASGHYTRIEPAVSAQPSYVPRSPPMTNHCSGSVYSNSVYGSHKRSRSSAWDGQGRYSPTGSVDDIIASPSLSDYSLDNGLDLVLPTNKPKQQNNKPRSQRRPSNRDEFDGPHQFLQRPPPDVIAMQERELPHLPTNLHVQEQDNVLNQVNDRLSQCAYDFVAKYQFPIPLTQDMRPVERPQDREWTEWVYLLKRLATKRRIPARVLYNGQIKQFVTILENSLEMRHAAKHQSRPLKDDRNILQLISAGIQVAKILKDASAMDYLDRLYVSTEKQIQERANARFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2X7</accession>
    <name>A0A2T4C2X7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1334473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2X7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2X7"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="188"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="641" mass="71973" checksum="10BF56A8933C5505" modified="2018-07-18" version="1">MVCDDCWHAFFSFSAFQAAWRVGLERTSLIRFRGCNYQRSLDAMGESAANGCRWCFVVGETIKDKVNKFRPANPVPIYVTFGFGSGEDRNLSALHLDIPDINASRIFEVYTSDDNNAGRFLETRDVPRQMDSTATYEHARRRLEECHHHEACPSPLPAVLPTRVLDCSNPAQPRLFINDGAGLEHALYAALSYVWGEDQPHKTTSQNIESYISCIDVQYIPRTVRDAITVAHELGVRYLWVDSFCIVQDSSEDKAREISRMRTIFSNAYATIVAASANRVSDGFLHRREPRPLVDLPFICPDRTLGTMTISLPSLEPLTAPWPPDTRAWCLEERLLSQRLLLFSGHTLEYECQTTHVNIDGSTRLCSNPSICRLPDRAFSASSKDAPRPNMELRRNNPTLRSQYGTWRRILQEYTARSLTKPRDRLNALAGVAEHFGHTLGSVYHAGLWSFELPWGLLWYRNANAELRRRPKAYRAPSWSWAAIDGEVVGYDPIAYTRLFQLQGLGSSPLCQVVACETVPTNPVNRYGAVSSGYITLSAAIQEARWAAGSSLLERDGSERAGVLIGTIHCDAEEACVADVVVAFVCEHKKGHVVGLVLVMIDAEHPAYRTDLVQYRRVGRCEVVPDVYKRVSSARIDLVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C311</accession>
    <name>A0A2T4C311_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1302988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C311"/>
    <dbReference type="STRING" id="983965.A0A2T4C311"/>
    <dbReference type="OrthoDB" id="4898213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="247" mass="27228" checksum="BE6A070369F82FC3" modified="2018-07-18" version="1" fragment="single">NVCHTMSGSFQASGNEFARQWTQPTDIFSVLLILGGDVIQLACASMAGGTSIPPNPVTFSFGWVAYAVSALLSAIGENRLITCQPEAPLLVINLKSGYRRSNNSWLLGRLVKTYEHWMPDEVQRHLRPLKKKKMMKRRAGAGYISALCIAVYEWQPGWKPGVPQRDLAWWSGYLVSFMQLAVSVIPLGLHGDWAILLTTAAGTLLSYTSASLPQWRVEKWKARITEKPKSVALTAGNGSRNVIIIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C375</accession>
    <name>A0A2T4C375_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 3'-terminal phosphate cyclase insert domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C375"/>
    <dbReference type="STRING" id="983965.A0A2T4C375"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="17112" checksum="D44AFE8FDBFA688C" modified="2018-07-18" version="1" fragment="single">VNPFVTDIHIAAQYDQAPLVPTGDKAGSKRRLGIGYGLSLVAESNAVGVIYSADVVVLPSGGEVPEDIGKRCAYQLLETIAKGGCVTPVSAGTVLTLMAMGSEDVGRLRIGRDILGTEEIVQLARDLKTFGASSWGLRDVEDDDSGDIIVSVKGTGVGNVGRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3M5</accession>
    <name>A0A2T4C3M5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 17">Sortilin VPS10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">Vacuolar carboxypeptidase Sorting receptor VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">M440DRAFT_1422278</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C3M5"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015697747" description="Vacuolar protein sorting/targeting protein 10" evidence="22">
        <location>
            <begin position="28"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1378"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1424"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="23">
        <location>
            <begin position="922"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PTB76153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1508" mass="169275" checksum="09C43597C6B1ED8E" modified="2018-07-18" version="1">MMRLTAKAAAPSWHLLLLSLLWVLALAKDQPKLSVTKFDNPPLGLAYFEDSDVVVFHDVEQGIIYRSKDAGANWAKVEAIPKGDAMLLLTHPFDPEMAYVLTAGKTHYKSEDRGQTWLRFETPVVPSRFQPEIMVFHADDPKRVIFNGMDCDGIFCDEQASYTTNNFKTVDLLRAYTAGCWWAKLSPEFTTGDKDLDQRRVLCIVKDPFSLFVEDQRLVISDDFFAVVNKEVQEFEPNMDTNKGVGGVANIAVVKSYLLVATSSFQSDEMALYVTDDTLKWHRAMFPTSDNHDHSHQINQEAYTVLESTSYSIQIDVMTSSPSNPMGVLFTSNSNGTYFTENVPYTNRNSKGHVDFEKVQGIQGIFIVNVVENGADVDTKGAEKHIITQISFDDGRTFEEIKAGGDRIHLHSVTELDNMGRVFSSPAPGLVMGNGNTGKALGKFADANLYVSDDAGMTWKEALKGPHKYEFGDQGSVLVAVADSKQDDVSEFAYSLDHGENWERVTLPKKLAIKPAVLTTTQDSTSLKFLLIGQTADAYYTIAIDFTALKKRTCGENDLEDWYARVDDDGKPTCIMGHKQTFRRRKKTADCFINSNFKDPVANTDNCECTDADFECDYNFRRDPDDNKVCKQVGPLPAPDGACKSKSDTFKGSSGWRLIPGNTCKRTKGAQKDDPVERKCSDASVPSTPANGDITSKQFIFDTKLQDFQKIYLDRSDSSQSDDETVIVRPAEDEGGGRYKIEQKIWLSSDHGKSFKRILEGEKIQGIYPHAYLKDLVYFTTGSDKVIYSLDRGKSFHSFKAPTDPGDQFPLSFHPDKRDWLIWVGQTCDKVGGKETCFREASISLDRGDNWKTMLRFAERCEFTGHSAYNFRSQRQIVCLAREEENSDAPLTIMTSDDFFQEDKSVFKESVTNFATMNEFIVVAGRDPETDDMHALASLDGKHFERAHFPYNFHEGHENEYTLLDSSTHAINLFVRTEGGADREYGSIIKSNSNGTSYVLSAANVNCNEETYVDFEKVPGLEGVTLINVVTNTDTEQKTKDLQTKISHNDGSEWGFLPPPAKDVDGKAYPCSSSKGDERCALHLHHYTERDDKRKTFAAATAVGLIFGVGNVGSKLGDIKDSDTFMSTDGGVSWKNVKKGSWSWQYGDQGSIIVLVQRYTRNNQVKTRYVSYSTDEGNTWKDFEFADSDVAVLDITTLRSGTSRNFLLWCRSGRGRLFSVNLDFSGLADRPCEHTKNGDSDYYLWSPKHPLQDDDCLFGHVSKYLRKKTDRQCYNKNNLQRLYEHEDCPCSRRDYECDFNFELDNHGQCKLVKGFTPLSGDEWCEKHPNATSYFEPTGYRRVPLSTCRGGNELDKTSTEHPCKGHEDEFERKHRTSGVAIFFAVVIPFALAGIMGWYVYRNWSGKIGQIRLGENSSTFDSDQPWIKYPIIAVSAVAAVAVSLPAILSSLGRMASSAFGRFGQRSDGSWFSRGTRRFTTRDSFARGRGEYSIVDDDEGELLGDESDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3T7</accession>
    <name>A0A2T4C3T7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3T7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015544255" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11298" checksum="EC488E971C030098" modified="2018-07-18" version="1">MLKRSGWTWVSQWLFQVGWRLDPGLVRCDDGDGDGDERRGECVEMMLVVRDRGWLLQTVFAVNTLQPYGRVRPMQERNFTRQLPLRQVSIQPIHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4G7</accession>
    <name>A0A2T4C4G7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1315240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4G7"/>
    <dbReference type="STRING" id="983965.A0A2T4C4G7"/>
    <dbReference type="OrthoDB" id="5304511at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="174" mass="19722" checksum="DC344482356E837F" modified="2018-07-18" version="1" fragment="single">TILPNVIDVSIESDTSLHFHLQGILQTATKKPLTSSNMLAIPLLEGKREQACIPIRQRILSYLDIGDLNRAIHASPLLLQAFRFTRKQLLLCTLFNPLGTTILEAFAVYRTMSIGFQASRTEEKVSLFLQALEKHRPRPTLMFELCGFFSEDDLVQMATFHNRVVRPLTQLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4K4</accession>
    <name>A0A2T4C4K4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_4950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4K4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4K4"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="32905" checksum="F849E0878CEB7FCB" modified="2018-07-18" version="1">MKTEDSASRPLAATLSAITTTTTTPSTSQSQSQPQTHTHSKWKTKNLASRLAADALSASCAGALIAPIITIIDRSIMENASGRRPLSTSLLTSLQSLLSRPQTILLSRPTALVFALYAGTYLTANAIDTLSSTLSNLPASHTTSGPAKFAASSAANVGLCVYKDQVFVRLFAPPGAAAAAARPVSLPSYILFATRDCLTIFASFNLPPLLAPRIDARLSESLKRSVSGLTAAQFLAPASVQLFSTPIHLLGLDMYNRPDAATTWSQRWRAVRSNWLVSTVARVCRIVPAFGVGGVVNTKARRHLMERVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4L8</accession>
    <name>A0A2T4C4L8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4L8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4L8"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="231" mass="25734" checksum="2BCC15EF236B1979" modified="2018-07-18" version="1">MTIHIREAIPADLPAIARIASAAFHPSTDVIAARLFSAHLQQQESIRDNDVFTWRYAKKTASLSSPNTVMVVAVDDSLPVTDQVVGFGLWDVYEYKPKAAHNARADTESEKAANQPRTAVQEVPPPSFDQEAYAELRAIVSADHQEMFGERGIKDVWHLDYLGVDPQHQRKGIGRMLLDWGLSRAASENKDCYLTATPAGRPLYTKSGFEVVRTVPIFGVPHHSMIFRHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4P7</accession>
    <name>A0A2T4C4P7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_362877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4P7"/>
    <dbReference type="STRING" id="983965.A0A2T4C4P7"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="220" mass="25192" checksum="5391EDA8E05E5A56" modified="2018-07-18" version="1">MSSDEKPQDQEYSSKEEQEHQDDQEQQDSSDQNQQDDNDNDDNDDNASDHQQDSQQNGRTGELSEDNSSDRDEDNEPTTPPAPERQRSSGRGARGARGGGGDDDGDDAGREKAQTQTKTQNRRRRRGAPFQRQAQDDFDDERGQDMVPHQQRQQQMYQPQQPMQMQQQQMQQQQQQMQQGGKKDDGKNPLKLRLDLNLDIQIELKAKIHGDLTLALLDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4V0</accession>
    <name>A0A2T4C4V0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1254948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4V0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="73" mass="8187" checksum="1856CB459FF3B2A4" modified="2018-07-18" version="1">MPRAAYLGWMSTICYAIHSVRLCSPRIHPASNLDSVRQGAYLLLVVVVYVAGEILPAMQDRLSLMLNYPPNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4V9</accession>
    <name>A0A2T4C4V9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1333817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4V9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="508" mass="55863" checksum="A1BEA113FA084DCC" modified="2018-07-18" version="1">MKESRMQAALLRENPRVFRNSFLKLYGCIFVGYLCSATNGFDSNTFGGLSAIPQFTKYFGINTQNQGLVAALYVIGNIAGSFVAGPCSDTYGRRVGMAMGSAICVIGAILQTAGTNLSMLMGGRFILGMGAVLVQTAGPSYVVEMSYPKYRAQLTGAYQACFFLGTIVSTWLEFGLNHAKTTLSYPWRLPLAIQGLPSVVILCAIWFIPESPRWYVGQGRISEARAILIKYHGDGKPDALVANLELQEMIEVIEMDGSDKRWWDYRCLFDTRAARYRTFLVLCIAWFGELDLPPTSYYFPLMVKTVGITDVNTQLLLNAIQTPVMAAAALCGLSVVHKFGRRKLLMFSSAGMSVSIAIITACTALQAGRPAVGGTGIAFLYVFLVVFAFAWTPMQSLYPVEVLSFNSRAKGMAFLAFMNNAVKVMNTYVPPIAIANSGWKYYLLYVFWDAFGVVVIYFFFVETRGWSLEEIENLFQAKNPVKASLEKKNIGVAHDGTITHVQGSGSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Y5</accession>
    <name>A0A2T4C5Y5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1391490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Y5"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Y5"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="517" mass="57116" checksum="6223BE1F65F07978" modified="2018-07-18" version="1">MAVPTRRQARAASRAGRTTASSMARSRNSTTASSRYYASSRQHDQTSSYVSGSYYDDSRHSSRDTWERDTWEDLPPSIVDTGSDSSSSVYTYDSAYSDDRSSESHHDSEHDKKDIEGDDCAASSGIPPSTLPPYNCMPVPEISVRSSDPETFAHLFPSMDRLSIRHDDRTADGNMNLRVDAIVPDLSSRRRRAVAIQLFHLRMQDLAKREFSLRRYCRDSGREVCNSKGANPRRERATSSSSSSLSRSVTSALRTVKTSFRRSSGASAEKTAALSTAPNPRRPSIGSNNSWGCSGSIYSEEAAGSESDEPKLPSARPIPLNTLKLEFSNYARVDIVRRPGKQYDFQWWGHGYAWRRVMDKALGKAAFHLLRDRETEPVAIIVPEGRSPNQVEADQMAGNWIPPCYMWICDRSVIDAVTDVADIIIATGLMALVDDSILSRWPPAKKAGTYTRPVTPARPHTAPGATTTTVAAPRIVVTKNTAVSAPHTRPRMLVHGLLNKAHTLSPLRLRGHTIVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C732</accession>
    <name>A0A2T4C732_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1455198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C732"/>
    <dbReference type="OrthoDB" id="2885612at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="470" mass="52940" checksum="C462AB44C1F692F9" modified="2018-07-18" version="1">MEDEAVRMRWLSGRPRRVLNLRRPPGLSQMNSYHAQWSVMDDQIMATLPSTTDALSPSTVYLTDIKDGLTRDDDTVEFRQIAELPFHAARSRLLSNREGFITAEFRQSQAELILRTHDWGGSVKREKTVAAEAVDGEIAVHGSSVAVCIRIDIQKPSTNCLGTSTHIFVWDTETGDTTRVEIPQDDRAPQCVRTLAHGHLLDPHHCLLTPYAVLRSIQIASSEQNPGRYFHHHENFEYGNNHDAIAIPGSSARNRVLVHHHQNESRFTVADVGLLTGEIPSVPEPTPRYFIDPDYHKDLFHVFSNKTSARTLNGAIFDSLPALAGNRLLDRCRALRQLPPPERRTLEAQLRELNPDARVTVTSRMFYASIEDEDDMEKDPSPEWEAHVRELWEVGQARQRGEAKFPALEFDEPPKGHDDDARMLFTRSMVCLPRVRDGEALALTASAIVELPTPMADGYVHLSDIDSLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C754</accession>
    <name>A0A2T4C754_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1429948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C754"/>
    <dbReference type="STRING" id="983965.A0A2T4C754"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="509" mass="54688" checksum="76704BFFAFEB6D5B" modified="2018-07-18" version="1">MWVGGERREGSGELFTIENPATGEKIAEHHAASDQDVDDTIQLAHRVFKSGIWSKAPRHTRADVLDRAAELLTSNLRTLIKFEVAQTGRPAREMQAQVPSLVRWFRYYAAVLRTEERPVLPTTGKLHNWLERVPLGVVVQITPFNHPLLIAVKKLAPALAAGNSVVLKPSELTPLTSVLLGPILKEAGLPDGVFNVVLGFGATTGRALVSHALVRKVDVTGGTAAGRAIGSIVGKNLARFTAELGGKAPLIIFEKANVDLAVNGVAFGSFIASGQTCVAATRIIVHRSILPAVEEKLVRKAESITRRMGSPKNFQSSMGPLISSKQLANVVNLVDGAVADGARVLCGGKRMSGISALDETDFSKGYFFPPTILSSSSTCDITKSKIWREEAFGPVIVLVGFESEQEALEVANDGEFALGAALWTDDLSQAFRVSEQIESGIVWVNTHHRNDPSSPWGGASNASGVGSENGVEAYYAYTTTKSIIVNYASSEEAAADDWFREDDVEVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7F9</accession>
    <name>A0A2T4C7F9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RINT-1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1421258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7F9"/>
    <dbReference type="STRING" id="983965.A0A2T4C7F9"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="89482" checksum="ED49631ADE44C83A" modified="2018-07-18" version="1">MSSMSAVANGVSLDTRVEDYLEDKLQSTADLENLDELLNNVELQRNQLQSQLDDAVKQLDEARRIAEERQAELQTRISEFNEMQESIDRRVQIAAASDAPSEAIARLQKPMKQLQNIELAQKYFMLLQDAERLRKEARSHLPHSPKEALEPYAQLRELVIKLRSLPGNDELHLVDHVDRMTKNLWAEMKHIMSAELEAVLNKKQWPKVDPQSEMDEEWVACIEKLLDLQMPEIVHSTDVVTLLPFEVMAKMFVAEFRFHFLSDKPTSSPQSVGTHCFPWLLTTLEKWEDFFRDNLGHLLASKFRDTPVADKTIYADPPCALITAMLPVVREKVDAVLTETSANAGFLSSFISQLMTLDETIRSRFNYDGGDPDKGWAGLSESVLDRYFDVWFQAERSFALERFEVIMESRDARKIDYDYSLPGKMKPTFAAVQITDLLRVVTTKYERLRKVKQKLKFLTDIQLDILDAYHDRLRSSLEAYQALTSTLGRTIHGVTKEQLAALEGTGALETLCKVIGSADHIANTLAEWGDEEFFVILWDQLHKRESRQFRHQTSAIASVVGAGDDLKERTVAAVDEGDENGAIFDETIAAYTNRRKAGEGLLVGALVESHSKALRAYTHNVQWTTVGESATPDDSSALSITPELDEPLSVLKRNLEFLGKALSAASYRRVWRDALDKLQDLLWSSVLTRQTFTTLGAAQFAHDCASIFSLVDRYIPNGSAALEALREGLVLLNLPAAAEGEGMTLKQASDRAFRDNDEARRVLEELELVALTPLNARQILQKRVENNENVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7J0</accession>
    <name>A0A2T4C7J0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1400477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7J0"/>
    <dbReference type="STRING" id="983965.A0A2T4C7J0"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="303"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="697" mass="78800" checksum="D5D0A7CE6C9DC07D" modified="2018-07-18" version="1">MRTGFVLGRLCGRTLFRPHPALRQTGCGSGARLRGWIHTARRTAWRGGERPRPRLALCSSAGAAALGAGAFIQLSQADNGESDKTGEDRMLEVSREEIRKTIRDDERGIARLVHQALLFWDLYIWEPICTGTRFLHLVVIFVPVILSVPVIWFGRRHPDKDDERSGTLWWYGFLVKSMELAGPAFIKLGQWAASRTDIFPTAMCEAMSKLHSNAPAHSMRVTRRTVEAAFNGRSFDDIFDEFQETPLGVGAIAQVYKAKLKPDFALPQEQDVVHKELKPLTQNVKQRVRTVLKSSPNPVPSTYVAVKVLHPNVERIVQRDLRIMGFFATILNAIPTIEWLSLPDEVAQFGEMMKLQLDLRIEAANLERFRRNFKDRTTASFPIPYSEFTTRNVLIEEFAQGIPLADFMENGGGVFQHDIADEGLDAFLRMLLLDNFVHADLHPGNIMVRFYQSAQPNLRLRRSTEKPSPSDGNDRHLDVTEQVLERLRPFRHRKDKSAWEAELAKLDAEGYRPQLCFIDTGLVTELNAVNRDNFLDLFRAVAEFDGYKAGHLMCERCRQPEAVIDKEVFALKMQHLVLSVKSRTLALGNVKIGDILQQVLSMVRNHHVRMEGDFVNVVISILLLEGIGRSLNPDVDLLSASLPILRQLSAQSGAAMAKHGDFSMIMLWMGLETRKFLQASVDDVERCVKYDLLSPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7W1</accession>
    <name>A0A2T4C7W1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_51808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7W1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7W1"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21463" checksum="10C9D2E145AC5296" modified="2018-07-18" version="1">MLSGTSVVYERKVVTTHIRTYNWPPLQLNFWIFVMLLCACTIIGVFGSFIQIQNQLELPIPWYFPYYITVGAIALLFIFGIFWLIARRRLLPAIVMIGAFMLFVMWLVGLVVVSLELWGPNGSIQDTCDRNVFNQDPRGRNQETLAWLQQKMICQCWDLVFAMALTGAIFLFWVMIMAYQVFARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8A7</accession>
    <name>A0A2T4C8A7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM7</name>
        <name evidence="3" type="ORF">M440DRAFT_1330107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8A7"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="570" mass="62990" checksum="15953644669F3DCB" modified="2018-07-18" version="1">MEEGDDYGTGGLMDDPEDYYPSTPPPTTQIFTMGSGKEVVLHLVGHSPTEAHHLWNGAKIISDYFEEDPARVRGKTVLELGAASGLPSLVAGILGAKKVVMTDFPDPDLVMNMQKNIDECDETTEPKGHIARTIDAAGFVWGGDPAPLLARLSEEKTSGDGDAAASSSTKEERFDVLILADLLFRHSEHGALVKTIRETMKRSRESAAYVFFTSYRPWKKDLDMGFFDVAREAGFEVEQVLEKKLEKPLFENDPGDLDVQKTVKGFVVRLTMPAQTPSPSSSSHLTQLQTNGFVVIPSILPPSQLTLLRTAAQQATALARAGKWPHVRTVGKQFPPWNPADAQSQGIWGVQHLMSPQLPGHAEFTALYFSEEILGIVKELLGNCGDEELVMELFNMLVRPERDFELRWHRDDIPAEASAEEEMERLGRPAFHAQYNLALWEDESLVVVPGSHVRARTEVERRAGPFEKELPGQLVVKLEPGDIVFYNNNILHRGVYDSTKERATLHGSVGHVAGSRLRARNVLQHGVGAWVDGVDLGQLGEVERRRAEGMRERLVRMGGESGEVGYSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8A9</accession>
    <name>A0A2T4C8A9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1391027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8A9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="194" mass="22468" checksum="C5033753C21C4E7A" modified="2018-07-18" version="1">MDGKQQFLRSRTWLCKKTAILIEWRIRQLSVICWRSEVLSIDGMMMNDWNDFNDPKRLDRNGDGIPYSNETQLDDWVLTIACKVQTSGLKRHRRNRYGASSLPYSPSTLRRRPSDHWTCFLGSPRLPVSIFPRHHVHLIQIHWILQTCNHRLPAGLNVAKSPRLHNSQADLFYQLPFYGLQQIASIATAAACAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8H1</accession>
    <name>A0A2T4C8H1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_292638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8H1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="201" mass="22648" checksum="6221A88528CFC74B" modified="2018-07-18" version="1">MRKRKEWKSRCLGPGVVLRRTLPPCMNKGELHSLKVSHAQSVRHPQTRDSPIRAEKLGIIQSEKVEKGLGRQREGRHVRLLVPWEAHRMTFTKLIQTANQPIIPSHPDATRVGGKRWVGLLASRIRRGAPVPKQTICFGTCWMDGPRGSIWASDTRDVLLLLVRVCVCMFIDPWVGHISVDMYCQSRDEPDNGGSSSTNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8I7</accession>
    <name>A0A2T4C8I7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1331634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8I7"/>
    <dbReference type="STRING" id="983965.A0A2T4C8I7"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1170:FF:000001">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="10">
        <location>
            <begin position="356"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB77876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="725" mass="80886" checksum="13CD7806D4EC6969" modified="2018-07-18" version="1">MASKNIFAEPIDVKLPPPQISTRKDHPVPRKGIAQNAPLQTNKFYSNFFLEDQRCPTFTFPYSLAWAGGKGTTASWGMACSHTEASQRVFGKEKFNGASSYYLNPVGIQSLVLSAKELGKDTKLSIDSMTAFSARVHLSKDDGSPPAISFPLVQGMAYITAQYSGATPVIQSGVYFKTMTRVTRDLKKDLAKFTFHLEDGSTWLLYAWKTKGDPLDLKVTNNGLAESKMPFYGIIQVCKCPKSQQSEHILDDGAGIYPVSLELTGTARGSEGSYSFNFLIDGHQTGNLYMYALPHHVESFDQETSGRIQKETQLQSTTKGLATLVKGNHWTMVEPKMPVDMSFAPWDPKKGSIEKLSDHAKSIIRSAAAKEVAQNMISQSNLDSMYFSGKALAKFATIMYVIKDMLGDKALMQTGLGQLKAAFATFAANEQKFPLVHETAWGGIVSSASYVTGNSGADFGNTYYNDHHFHYGYHILAGAMIGYLDPEWLKQNKDYINVLARDVANPSAKDKLFPMWRNFDWYHGHSWAHGLYAAMDGKDQESSSEDMMHAYALKMWGKVSKNADLEARGNLQLSILARSLQNYYLYKNDNKVQPKQFIGNKVAGILFENKVDHTTYFDPNIEAIQGIHMIPILPSTPFVRPREFVQEEWDAFFSNGRIDDIGNAWKGIIWASYASVEPKKAWEFFSSRSFDPQWLDGGASLTWFMAYSAGESCVHLLKLGDLSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C916</accession>
    <name>A0A2T4C916_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_252222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C916"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="125" mass="14186" checksum="6C76A1D166662CA3" modified="2018-07-18" version="1">MYQGLQDGTTAPSSPGWPSWPRQGRWDVCCQKSECRMMTVVWFLWRERRTEIDDWLPRARAALLLSGGFGSTQQVVILLKKCSVHLSVVSAQKGETGWAQSPRIESSSIAPVLFSTSWARSRWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C947</accession>
    <name>A0A2T4C947_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1328378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C947"/>
    <dbReference type="STRING" id="983965.A0A2T4C947"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="21076" checksum="2D12E05B21541F08" modified="2018-07-18" version="1">MSSLKGPAPQHHDGSSLRIGIVHARWNSTIIDPLVAGAKAKLLEAGVKESNIVIQSCPGSWELPIAVQRLFSASQIQSNASGAPSATDLLGASTSDLTALSAGANSSGPFDAIIAVGVLIKGETMHFEYIADAVSQGLMRVQLDIGIPVIFGVLTVLDDEQAKSRAGISTSAAGKGHNHGEDWGLAAVEMGVKKNEWATGKIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9I2</accession>
    <name>A0A2T4C9I2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1420379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9I2"/>
    <dbReference type="STRING" id="983965.A0A2T4C9I2"/>
    <dbReference type="OrthoDB" id="5239982at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015548571" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19183" checksum="3160CD275E9D255D" modified="2018-07-18" version="1">MRFQIASILAALPFSLANVADLSYSAPPERLAAAQKEAGCNLPAGFQLKGFTAKTNGTGQTPALTAYNFDYSDPDTKVALKCSYNSSSVSTTPGSLTPRYACENSDVKFILSGATGRTLTLIERICPGPDGVKGYEVAGAVDLVLNCSTTLGSCKTSSNDIRGNFTALDPVTDPTRIKRWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Z2</accession>
    <name>A0A2T4C9Z2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1191213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Z2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="148" mass="16264" checksum="711D65A499C6487B" modified="2018-07-18" version="1">MRRAERRMGQTSWPAAGKCHIHMCVRNHTESPSQIRHTSSRFLLSPESQESRRREGTSRRGGGATGGLPWPSLVFFFLFSFGIHFLSLVPASVCACVVRCACLGQQKAAAAAPPPAGTRRFLITCIYGWPFGRKGPSRPHLCLRNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAE0</accession>
    <name>A0A2T4CAE0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1328093</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CAE0"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024468">
        <property type="entry name" value="Sec16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12935">
        <property type="entry name" value="Sec16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 N-terminal" evidence="14">
        <location>
            <begin position="240"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="912"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1090"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1461"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1728"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1415"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1461"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1490"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1534"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1576"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1610"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1643"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1807"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1840"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB78531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1857" mass="196852" checksum="AC1970F389706A6A" modified="2018-07-18" version="1">MPNSTHDSVAAHDDHAEPLTEAQGNGLEHNEEPTAWSLHENGRHVEPQPSSPGGDAEGGAEGDAGLASEVPTSHQEAAETPTEPPAPAAAAAAAATAEGGGGDDTTATTTRTSQHSSSMSFTRTVSDEVSFSDNDETEWGLSRTDTDPFKFMSPSDRTNSFPVVPLMAEEPEHIDDVHLPSNQALDVLEETERDGHVEEEEYRAEAHPEPSSDAASEPRKDSKRGHAPSRSIGGDVQWSEDVESEARFEEGVPLIPHSHANSETPAGGDKAPIVSFDDDNEDDDFFNQVSQSAQEDTSTGEDVQPLQRKSTMQVLASAGPEPISHQPTLDQTPEWDEEGLLSPKANPTEKPGPFDGHDKPNETEAASSQDLSSKWEEAFASDDDGEGFLIEQDATAGEKEIDAAAFLGSDDEGLLDDLEEEAPPTQTAPLSSQASSVTSTSAFAPTSYVPTQQRSASASAYTPVTTPSQPSFYGGAPSQGPSLPSTTPYGQAPPPQHTSDSPAVQSSVDKPKGGSSLAFDLPPDLVTSKVKPRKRASLQQLPLENASPSLQPPPPPRSASMNASIGSTEATPPGGFQKSPLLRHKSSFFEDLPAAPRSRPISRQSARAISPNPYALATSPHGPSPLSPPMATQIPPAAAAPAARPNLVAPERVSPYAPLQSPTAPLPSPAANVSRYSPAPPPPQGAGSQSAPPPTGRYSPAPAASHPTSAYAPAVTATPPQPVLPHLPRTSSPLAHFEISSDKPHGVNGEPVHTERRASSSYEPRLNRVPSLPPTREVEEEEDQFSGAPRLSATRSPPPPALPTLSAQATLSPPKRPGSGYIPGGVPSVQPGFVPPPRAQTQSPGATRGSQYGPKPLEPARRPSSSHTPVSPPAAKTTYAPTTHSRSQFLAMSMVAPTDGREHDPLQRWQGVPIISWGVGGVVVTSFPKSIPRYVMNQTTPSMLRAPGEVKVRNIKDIESLPDRLAKFPGPLKGKSKKKEVLTWLSAGIDSLEKELPEVSFHPQLSHEVKRTIERLLLWKILRVFVEYDGVLEGNPAAEKAVRDVLSPGTVTPTAENDALFPVDPALAITGTAVSSMQADGADPAAMEQIRRHLLKGDRENAVWTAVDKRLWGHAMLISHTVSPDLYKRVAQEFVRKEVNHPGQNNESLAALYKVLSGNYDDCVDELVPVHARAGMRLVSTGSSSEPTKDAMEGLDKWRETLTLVLSNRSADDIRGLNALGKLLSSYGRAEAAHICFLFSRQISVFGGFDDPNVDFVLLGSDHRQNSHQIAKDTEALQLSEVYEYGLSLSGIPSAAAGAPHLAAYKLHHAMTLAEYGYRDRALQYCDAILTAISSQTKRSPHHHPLLEAAVDDFMVRLKQAPKEESSSWMSKPSMNKVSDSMWNRFNKFVAGEESENATGTPTEETGPFARIGTPSMSRSPSVSNFDTLGISSPSYPGAGAPAATSALSSALSRYAPVNSQPTFGAESPQVSSFSQPGRNSNEYNPSTYGASSSMAGSPPAHGNGFAPSGLSFQPMTPILKDEGSASYGGYQPYGTQDSASSMPAPRESTTGSSTQGYQPISYGYEPPAATPDAPGSGETNEGAAGASSSGGYEPPSYQPYGYEPPSYEPDAEPSAEADDDEPKPKKKSFMDDDDDDFPAPQAKEKSKAEKDRENQELFRKAAEEDAKRAAEAAQAKKGWGFTSWFGGSKKEAASPGEASSPGKPIKAKLGEASSFVYDPELKRWVNKKPGAEQVEAKAATPPPPKAGPRSVSGTPPLRQFTPPPAAGRSSLPPSTSSFGTLAPPPVLNRATSQESLSAPPMLRSMSGASTDSKPSSRPTTSMSNASSIDDLLSAGPRKPGQKKARKAGRYVDVMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAG5</accession>
    <name>A0A2T4CAG5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1352073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAG5"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="32"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="58709" checksum="1C0F1CF5978ECD22" modified="2018-07-18" version="1">MGVTSKFLRAIVRNDAMRTDPDEIYGWRVFTLVFSACFGGMLFGWDTGSIGGVLTMPDFQEKFHYADSSTKAKSNMNQNIVSTLQAGCFAACFFTSWVTDRYGRRFALIAAGFLTIIGIVFQAASAAKGTLAVMYVGRFIAGLGIGAASALTPLYVSECAPRAIRGGLTAFYQLFNVFGIMLAFWVNYGCLLHVPAPAIYIVPLTLQALPAVFLMVGMFVSPESPRWCARRDDWDRATRVLVKLRGLPADSEYVQNEIQEMADQLEHERRLTGDATFKTLLKEMWTIPGNRNRAVISILLMIFQQMTGVNAINYYAPQIFTNLGMTGNDSSLFATGVYGVVKTAACAVFLVFVADSLGRRWSLLWTAAAQGIFLYIVGIYGRVQPPIAGQPVTAFGYVAITCIYLWAASFQFGWGPVCWILVSEIPTARLRAMNVAIGAATQWLFNFVCARSVLTMQTTMGKAGYGMFFMFGTFCFIMGIFVWFFVPETKGLSLEHMDDLFGVTELVKKVEAEPELGHPDSIREERADIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAN2</accession>
    <name>A0A2T4CAN2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1327788</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAN2"/>
    <dbReference type="STRING" id="983965.A0A2T4CAN2"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="480"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB78637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112561" checksum="EFEBF9C1638281AE" modified="2018-07-18" version="1">MLRNAANTARKSVTDLALYPKPGSKLHGFTLVRAKHVPELELTALQLQHDKTGADYLHIARDDTNNVFSIGFKTNPPDDTGVPHILEHTTLCGSEKYPIRDPFFKMLPRTLSNFMNAMTASDHTFYPFATTNEQDFKNLMSVYLDATLHPLLKQSDFLQEGWRIGPENPLAEDAEGKKLVFKGVVYNEMKGQMSDAGYLYYIRFHDHIFPDINNSGGDPQKITDLTYEQLKNFHAENYHPSNAKLFTYGDMPLADHLREVDARLQAFEKIAKDKVIHLPIELNGPQEVTLQGPLDPLVAPDRQYKTSVSWITGDTTDVVESFSVSLLSTLLMDGYGSPLYRGLIEAGMGADWSPNAGYDSYAKRGIFSIGLTGVQESDVPKVKGKIQEILREVRDKGFDQGKIDGTLHQLELSLKHKTANFGYSMLNRLKPKWFNGTDPFNSLAWNDTIAAFQAKMAEGGYLEGLMDKYLLNDNTLTFTMAPSATFGDDLIAEEQARLSSKIQDAVKKAGDEEAARLQFEKQEQDLLVEQNKTNTEDLSCLPTVHVKDIPRSIEPTVVRDEIADGIPIQWREAPTNGLTYFRAINTLEGLPDDLRELIPLFTDSIMRLGTRDMTMEHLEDLIKLKTGGVSVGYHSTASPTDFTQSSEGIIFTGMALDRNVPVMYDILRKLVQETDFDSPEASLRIRQLLQASADGVVNDIASSGHRFAMGHAESSLTRSAWLRQQVAGLSQVKLVTSLTSRPETDQLEDVIGRLKKIQEFALTRGKMRTALTCGAEHVEENLNSLKSFTGVLPRQVPGMTTSSPSPLPRDSKAFFPLPYQVYYGGLSVATTSYTSPEGAPLQILSQLLTHKHLHHEIREKGGAYGGGAYSKALDGLFGFYSYRDPNPQNTLNIMRNAGRWAVEKQWSDRDLEEAKISVFQGVDAPKSVNQEGMARFLSGITEEMKQRKREQLLDVTKDQVRDVAQKYLVDAIERGEERTTFLGEKQGWVDGTWTVHEMNVNGPQPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB87</accession>
    <name>A0A2T4CB87_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">M440DRAFT_1390427</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB87"/>
    <dbReference type="STRING" id="983965.A0A2T4CB87"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="556"/>
            <end position="578"/>
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        <location>
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            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="858"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="104"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
        <location>
            <begin position="249"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022857"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PTB78829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1108" mass="115461" checksum="3A83DB09B6E92FD0" modified="2018-07-18" version="1">MASSVLRPLATELYLSPSAASSQLLRSRIRIHDVKPLLNCRRHWHASAGVTRQTALVAAATKSLALVRHDSSVTRAPVLLPKPYSTEATAAVPPTTPYSQLTVGVPKETYPGERRVALTPANVALLLKKGFSKVLVERGAGASADFLDDAYEKAGATLVDSANGIWSAADIVLKVRGPSDSEVGAIKENQTIISFLQAGQNKDLINKIAARKATYFAMEMVPRISRAQVFDALSSMANIAGYKAVLEASNVFGRFLTGQVTAAGKIPPCKVLVIGAGVAGLSAIATARRMGAIVRGFDTRPAVREQIESLGAEFIEVDMQEDGSGAGGYAKEMSKEFIEAEMKLFKEQAKDVDIIITTALIPGRPAPKLITLDMLNVMKPGSVIVDLAAEAGGNCEATKAGEMITYNDVKVIGYTDLPSRLPTQSSTLYSNNITKLLLSMAPKEKEFGVDLSDEVVRGAIVMQNGEILPPAPRPAPPPAPAKPAAAVVVESVELTPWQKKTREVAAVTAGMTGALALGKFTGPLFMSNAFTFTLASLIGYRVVWGVAPALHSPLMSVTNAISGMVGVGGLFILGGGYLPETIPQALGALSVLLAFVNVGGGFVITKRMLDMFKRSTDPPEYPWLYAIPATLFGGGFIAAASTGAAGLVQAGYLISSVLCIGSLSGLASQATARMGNMLGILGVGSGVLASLAAVGFSPEVLTQFTGLAAFGAIAGMLIGRRITPTDLPQTVAALHSVVGLAAVLTSIGSVMADVSHLSTLHMVTAYLGVLIGGVTFTGSIVAFLKLAGRMGSRPKILPSRHLINSGLLATNAATFGAFLTMAPGAPAIAAGALAANTALSFIKGYTTTAAIGGADMPVVITVLNAYSGFALVAEGFMLDNPLLTSVGALIGVSGSILSYIMCVAMNRSLTNVLFGGLAAPTKALEYKPEGQVTETSVEDVADQLVNAESVIIVVGYGMAVAKAQYALSSIVQSLRSKGITVRFAIHPVAGRMPGQCNVLLAEASVPYDIVLEMDEINDDFPETDLVLVIGANDTVNPIAMEKGSSIEGMPVLHAWKAKQVVVMKRSLASGYADVPNPMFYMPNTKMLFGDAKVSCDAIKSAVEGKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB98</accession>
    <name>A0A2T4CB98_TRILO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1352650</name>
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    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5295335at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="450" mass="50343" checksum="69D951FB62B02D58" modified="2018-07-18" version="1">MSTVTAGALTAVIGYIGSEVAEENLLERLLWPERFNNDMTISVVLQQCLLMTAGGPLHKAALKTLETLRQQGLFAGSCRGHMLGSVFFPEFKIMHFQRCKEARRLIPEKSRNSFWIRVLHSVRAEQHVSFKIPRQDAESNQLSDAYRSLQPVYHLKLGIVGSAEKPGPNEVCVNEDGTSLTGVLSCVLSELTSVLASLIAGLKLKELVFALYLLVPLLLKLLLIAFSVRRVKLMTEEELHKVAEKEDTDLSKTEAFEVADPIHKFMVIEGPQPVVVQFFRHYGHPVRDRDSLWIGDRLREVACITVICCLFLFFPVGLVIAQCSDENAQYLWLSYELYAVIAMHIVRVCGWQDIGRIEKRIARLMSNGKTVWLKTGNGCTVSATLVIHGVTKTAEGKEKVQEIIDECTQRLVREAQSVEVEVEVETRAQEDSPSTQIQPAPAPAYLRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBK1</accession>
    <name>A0A2T4CBK1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1398200</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBK1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015766299" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8491" checksum="AE247E45C17AA605" modified="2018-07-18" version="1">MKFIWATLLVAASSALASPVAEADPGEPGYGDYGKYGEYGRYADYGKYNPPKGGYGDYKKYPEPKGGYGDYGKYPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBM5</accession>
    <name>A0A2T4CBM5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBM5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBM5"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052963">
        <property type="entry name" value="Pantetheine_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492:SF2">
        <property type="entry name" value="[ACYL-CARRIER-PROTEIN] PHOSPHODIESTERASE PPTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="308" mass="35324" checksum="0F8E2558DA16B9DD" modified="2018-07-18" version="1">MARLYAISDLHLAYPLNASAWNLLQPKPPGAGLILAGDIGESATHLIHAFERAKACFTHVFWVPGNHELYSVSSAMAKHPADHLRGEAKYNALVELARQHGVLTPEDDWMLWRQPDGVDVVIALVFTLYDYSFRPADISREQALEWAMAENVWATDEALLHPDPYGSRDEWCTQLCDRWELKFAEYARRYPNLKFVIVNHWPLREDLIYIPKIPRFTLWCGTKRTRDWAQSGHFGADYGGAEVVVTGHLHVRRTDIKEGVRYEEVSLGYPRQWEKARDADKGPNELLRQILPRTGSAEEGQRIWRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBS5</accession>
    <name>A0A2T4CBS5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1419409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBS5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBS5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="179" mass="19485" checksum="1D691FA80FBFC7B4" modified="2018-07-18" version="1">MSTRKRTRDEEDEEELVSLPEDDDGEEEEEYVSTGDEEENDDDDDAEEEEEDEEGDEDEEEGDAEEAAEPADAPVNGKQPPHKKRKTAEEGEEANGDVAEEQEKEEQEQEQEQEEEEAEGEEEGDAAEADAEEADVPEADEETADASAPAKAVKAPEAAQATEATDTPEPKAVTAGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC74</accession>
    <name>A0A2T4CC74_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1436480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC74"/>
    <dbReference type="OrthoDB" id="4892491at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015568945" evidence="2">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="37962" checksum="83BE8A42A8829A12" modified="2018-07-18" version="1">MKNPTVGHALAMGLAANLAAANPFSFPLPADNATCTTTSWVDLAAPAAVTSPTAVTVTKYSTVVYQHTAINCGGCGHLQIATRVEGSLPIETVTSAGAATITSGYCAGHGFFPMETGSLMRRHFEMVDPLEYNANDGDSGVLIQGDDDDENCVARVMEGPPYIDMGDTSVAFATTVTLTRTIDCGSCTKASPLPIHVSPPHLGTYNATMTIDAPYKTTQFVCGKTLPTDAAEAKKTKKKGKSKSRKASKTTPPKKTKATPTVTETWPPPLEVHTVYGKGRTTAECFYNYALYPDRLDHTRKIWTSTFTSVAHKKCDHCGLIWFTAPYDPPVPESVFTTTVFKKGRKTATAMACSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCI8</accession>
    <name>A0A2T4CCI8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1165461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCI8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="220" mass="24551" checksum="7472E1FD88FE6890" modified="2018-07-18" version="1">MPPSATQGLIDYFLLRPHHSHASVCLIPFTTLVAALAQHPSAYSQPIPGIMAFKHARRSCAALVDPVHLASTIFPKHRFASRRPHCHIHSLLNSRSAIPCTILIPQTRNHNTITQATKKHTKPLTSPLAARRPICATNTHKSIVSHPCSLSSSPFPLTVDDDFLFSFSKQESAIPRGMHDRHALRMKRIWDWGCLENSASSQSLCKRLKYIWTQAGLTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDK0</accession>
    <name>A0A2T4CDK0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="4">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1419965</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDK0"/>
    <dbReference type="STRING" id="983965.A0A2T4CDK0"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB79630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="77" mass="8953" checksum="47CAC0999E51047E" modified="2018-07-18" version="1" fragment="single">YEDGTPASTSQMAKDVVEFLNWAAEPEMDDRKKMGMKVLVATTALWAISVYVKRYKWAWLKSRKIVYDPPAETKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDL3</accession>
    <name>A0A2T4CDL3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1174872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDL3"/>
    <dbReference type="STRING" id="983965.A0A2T4CDL3"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="392"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="582" mass="63605" checksum="5BB0CD7E2FE92F1B" modified="2018-07-18" version="1">MEASSPLAALHRPMPAPAWGGRDIFRSHYKNKSASGSLSLREQLHKGTGDLFDIKGVRGSSPAASLAADLSENLEIDIEASPKLLTPRRALFTAKVVDGVSSTDFVATTPLISSSPIRAPGNIESSPLPHKVTFSNVVEIASPTPVSSAPNDATMLDSPAPIARRSSPEPARRARHASLEPLNPIASSPVQTLVRRGRGHTDSVASRRIAAPRRMTSGRLKTLSGGSLSSSQTSSPQFGANTSTLSLDECFESDSPEQDRSSSSRPSLSNSPCPSIPIGLRARSQLAGVVAGNNRHGSPGGLHSRRQSNPFLRTRKQFRRSLSMFESPSDVMKPKPEAALAASPILKPSVADIEEAHEPIIPHFLVDDPTDTIPRITKETMLAILDGKYSDKFAQRMVIDCRFEYEYEGGHIDSAVNHNNKELLANQLFETPMDGLTLLIFHCEYSAHRAPLMARHIRSHDRTINAEHYPRLTYPEIYILDGGYSGFFAEHRSRCFPPEYVEMSDEKHQRTCEREMGRLKARKPFGRAQTFAFGQRSTSLHDSPTGPSRPHSRNRNASPPAAPTTDSPSCGDRAQSRRMASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDQ5</accession>
    <name>A0A2T4CDQ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_359874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDQ5"/>
    <dbReference type="STRING" id="983965.A0A2T4CDQ5"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="246" mass="28211" checksum="44404D393C2C2A48" modified="2018-07-18" version="1">MATASNEHEVVLYDLACVKNICFSPTVWRIRLMLNYKRIPYKTVFLEMPDIEPTLKELGLPPHDPASGNKRSYTVPAIHHVPTNRYIMDSKPIAEFLESTYPEPPLQLTSELGSEIELKLRIMVAPALYQSIIPREVNILSPRAQEYFRRTCEAQLGKKLEDLLVGEVERWEASDTDWRAIGELMRRNREDGPFILGARPSYSDFFIAGSLQSVRAIEEALFLRIVQYPGFKDLYEASVPYSEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE28</accession>
    <name>A0A2T4CE28_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1327183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE28"/>
    <dbReference type="STRING" id="983965.A0A2T4CE28"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="59" mass="6784" checksum="8B0B49F9511CF350" modified="2018-07-18" version="1" fragment="single">FEKSLYDLIRGLRNHKGNEKEYIQKTLKECRAEVRSQDMGASLPFLLPSFLSLIVSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF56</accession>
    <name>A0A2T4CF56_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1323874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF56"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="797" mass="89303" checksum="6745CBA8BA018555" modified="2018-07-18" version="1">MYPSIHAKHIPSFLSSPLPSHSPRFHAILLALPISCHLANEESNSLVQGVQGKAVDRSPQSSSDGNRSQDRAGNRAAKSLHACLECQRRKIRCDGKQPCNRCQSSRSRRRCVYEQHRQRLVPSRKPLSRSLEECRSVLRRLFPNHEVSDLLSLSRQDLCGLLDQPVQRGTAGLSPVPSSPSNDQQHPKELEQMPAQDSQWDEERREQDPLPTEADDVNALSLTMDKQASSYLGASSVKVALTVMLQMQPQLQLLLASQSPPDASSDGNTRSRLPPFRAASKSAKKRSPIPWTYKGQALIDAYFRRVHVLTPFLDEASFRKHYSEGRRFDAPWLSLLNMVFATGSIMSTPSSNLSHIKYYNQAIEHIHLGAFGSSHIETIHALGLLGGYYLHYINRPNMANAIVGAILRMATALGLHREPPPEEPRSDPAVVESRRRTWWTLFCLDTWGTTTLGRPSFGRWGPAINIQPPQLVAENEEHDSAQFGGIMPLLENIKFCKIATKIQDMLAVTPLLKPEDRDSLDSLLVDWYEDLPWLLRSEEPCVESLHLSRSIMIWRYWNLRMLLYRPVLLTLASKGQLPTSEQDVAAVENCQAAARETVDSVSKGWMRQQMSGWNAVWFLYQAAMIPLVSILWQPDNPAVVEWRAQIEATLELFEAMKDWSLTARRSRDVVSRLLEASSKISDTRQDTDPQDASVKRGDDEASGFWADEGADGVGSTGYSTGDIVDMLDQDWPWSMDLDGLVWGQQIPLLEEDNLDNDAGVDEGVVGVDYLSLATEQSDALPPPRIFSPCPRDQAPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF71</accession>
    <name>A0A2T4CF71_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">M440DRAFT_1369145</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="22"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CF71"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 22" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="28">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="27">
        <location>
            <begin position="60"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="756"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="1006"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="26">
        <location>
            <begin position="1493"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="511"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="708"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="PTB80180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1598" mass="182232" checksum="1AFCDB37A6598E2A" modified="2018-07-18" version="1">MVLFRVRLNCIDHYQALPSRHDPQLRNDLQAPLLNATKVPVIRIFGSTEFGQKVCAHVHGVFPYLYVEYDGDLNQDAVGDFIYRLHLSIDHALAISYRRDQDGDKAKFVARITLVKGVPFYGYTVGYKPFLKIYMFNPMVMTRLADLLQQGVIMKRKFQPYEAHLQYLLQFMVDYNLYGCDYLESSQTYFRSPLPPRHEGGATTSQLWNEGTVPVGFVTDDLTLPRESYCSIEVDISAHTIINRDKIKERLLHQDFSEFTKPPAEDAKLVSSMAGLWKAEARRRQRQMPPDQTPAQHLASSFPREALVSMSADTRSSQPQAWMHEEDYRRKVELLISQEQEQFHGSELSLDTFVKPLPSESPIKTSLQSVEDLHPSNLSAALGLSLTSARPNEDPSSNIEVDEQKLQMSRLDEDAWLAAEVDGSDVEQESREKYSVPSLENSDTVPSKGTMAQSIKKPEAARFDSRYLGIGKSGLLSGRIPRLPSPFRLVEAAQRNRLTYTNDQTAATGLGIRPAGKRAASLADDNSAKRAKHDMIYQGKSLSSSTAVDGSRSSRLQPRSGSLQYIGHSKASQIDSVKTKPQAFGRFMTYATPPPSVADVTLQSEHCCPDVMYQDPFYSNEADVPLRRREYAGKEFQLISNTLPFLPEFDPASNAVPAWIGRGSDTSLSREADMWQYDQRLKGRCSWRGWEIARLPPSYDEVARSLARNEANGSRRAKPRSLRPWLSQIDGPTPRTKHNFRYSQKQPSSAVPHEAQYMSTMSLEIHVNTRANFVPNPEEDEIQCIFWHWKDDEATSSTTPEMPGSSGSGILVLSADSALAERIRSAVPDEVVEESSELDLLIRMVEIVRFYDPDILTGYEVHGSSWGYLIERARLKYDYDLCSEFSRMKTQSNGRFGKENDQWGFNTTSSIRVTGRHMINIWRAMRGEVNLLQYTMENVVWHLLHRRIPHYPWRSLTSWHRSGKPQDLVRLLKYYRTRTRLDLEILESNELISRTSEQARLLGVDFFSVFSRGSQFKVESIMFRIAKPENFMLVSPSRKQVGQQNALECLPLVMEPQSAFYSSPLVVLDFQSLYPSVMIAYNYCYSTFLGRITDWHGKSKMGFAEYRRQDGLMSLLAKHINIAPNGMMYVRAEVRKSLLAKMLTEILETRIMVKSGMKQDRDDKTLQQLLNNRQLALKLLANVTYGYTSASFSGRMPCSEIADSIVQTGRETLERATAYIHSVERWGAEVVYGDTDSLFVYLKGRSRDEAFAIGQEIAQAITERNPKPVKLKFEKVYHPCVLLAKKRYVGYKYESRDQVNPEFDAKGIETVRRDGTPAEQKIEEKALRLLFETADLSQIKEYFQEQCRKVMGGRVSIQDFCFAKEVRLGSYSEHGLPPAGALISARKMLQDSRAEPQYGERVPYVVITGAPGARLIDRCVSPEELLRNPHWQLDADYYITKNLIPPLERIFNLVGANVRQWYDAMPKIRRIQRTKGHGHKKRTLEAYMQSTNCLVCGRKVASSTEMSLCRLCYARVPDSLLTLQSKLVTVERKYDEIRRICQGCEGLGPLEEVACDSHDCPVFWTRTRLRSKMHHEQVVTEPLIHELYTSMEDLSLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFE0</accession>
    <name>A0A2T4CFE0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1397580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFE0"/>
    <dbReference type="STRING" id="983965.A0A2T4CFE0"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="131" mass="13813" checksum="D5DA595C6FB6525B" modified="2018-07-18" version="1">MQAAGSIFCGSWCPILQTSFPGGSERKSGPCRIATSTPVPDADTWLLSNSSLVMNGKMNRLASSTGSGHLGSAQDWRAATPCRFFQMGSCTKGSTCPFSHDKSIPIRSAPELQEVTSCPSLVKMPGRENAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG72</accession>
    <name>A0A2T4CG72_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1397934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG72"/>
    <dbReference type="STRING" id="983965.A0A2T4CG72"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="4">
        <location>
            <begin position="285"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="406" mass="45374" checksum="23CC5E293F4FD34A" modified="2018-07-18" version="1">MSIDQLADQVEQAMRLANQAPSDGTTTTPGPALPPQLAMNRNKTVDEVLADLNKSPLFMTEMEEDNDDIAALQALAYEGSPLENAADFRERGNECFKVRGYKDASEFYGKGISVLSLEERKRARGEITKHPETGEPDSEDEIRKQREMLEAMHVNRAACHLEMQNYRSCWTDCAAAIRLNPRNVKAYYRSARALLAVDRIEEADDVCARGLAIDPENKPLRSVAESIVKRAQTLAELKRKADAREAQKQRRALLLKTALAARGIATRTTEQPPEMEDAKVRLVPDEDDAASELAFPTVLLYPLHLESDFIKAFQETHCLEDHLSYIFPLPWDKEGEYTLGGVTCYVETKDGGLIKMGKKVPLLKVLSGGKVEVVDDVVKIFVVPTGKAEGWVKEFKEKRAAERGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH59</accession>
    <name>A0A2T4CH59_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH59"/>
    <dbReference type="STRING" id="983965.A0A2T4CH59"/>
    <dbReference type="OrthoDB" id="4738706at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="860"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113316" checksum="A3369C0C30150261" modified="2018-07-18" version="1">MHLPRPALSSKLPPLRIPTPSTERRDSLITYAYSSQRSAAPRSAVDADVEPLLPPLKRSRVGSLPRLQSIGELRLFHDQQPCLRCRATQKECDRGQPCSACANLPLISSEDHWAVIGCFRSSLSAFTDYLLPGTSFSQGQLHTPTSSTSPTRRQNVNDYLQRTCIFPAHIADHVMTCMDYRDAFWWSGQQSYRSFDGHHEAQQLTRDVADRPPPILCALAASWNCQETSSSPLELLRYTGYICPSREMEESQYPVLYHAKVLIRETAFYCLLHPKPVMQLDPSYGYRPPMDRLDFTGEHSRLVEHAMVVFLQAFEAIALRSSPLQSREWLAVFYSLCIFSIVRTLLMDLASVSVLPYPAFRLRSPLRDSPQNTIDGVYKALVHLFITGGPMLTDGSPSDLPQEDIPVYELARRIMRMDTWQARDIRSSADFLMSLGSGRTKDVYGYSGFIRPLQPIATHGSDAQLSTPQSVSAREPRWLSVGSSAFPPSSSQREILLGPHPEALDDANISRGAVTSSLSQPVPEHVGRARRHTVAEAPTNINPSSSIFGSHLTPMRFKPAYQRPPLRRVFCRKCHEYPEGFRGEHELRRHTDAKHAALVKRWVCCEPEGQSPAAPQPAIPLSSCKACVMQKHYGAYYNAAAHLRRAHFNPHRGGKASGDWPPMSLLKDWMREVRQSVAEAAGDADNDMSSEGEEDEDVKQHTRTVPLAAIPPASVMELPPPMPINSGHLSMSSVGSMTISPNVREEPVPWEMVSRSPAGRLAPPPPPPPPLSLPPPSSSQPPIPHHLPRPIPTPPAPENRSRCPFPDCGRVFKDLAAHMLTHQEERPEKCPIESCEYHTKGFARKYDKNRHALTHYRGTMVCPFCPGVGSAYAKAFNRADVFKRHLAAAHQVEQAPLHSHTTNRGGRLITLSANSGASAICSICNNRFAAPQDFYEHLDDCVLSVIVPAGTRAAMDTNNDANDDEKKTVRGGSAGAGGAGAGSERTVGNGIGNGNGTGNGNGTGTGTGSIDGTQGMIYIRRAKKSSRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHD9</accession>
    <name>A0A2T4CHD9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1960-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHD9"/>
    <dbReference type="STRING" id="983965.A0A2T4CHD9"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF2">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="12937" checksum="4600E2FC99A86ADA" modified="2018-07-18" version="1">MTRGEASQAKVHYKGKHDDFLVFVDDVNTYKKWLNDKSTPMAHFVSAFQVFVTHRQGVQGTYDSASKSTLSSEFDTDNTDDVIQKILEKGTLQISEMPERQGPTNDSMDNMRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHH0</accession>
    <name>A0A2T4CHH0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1323239</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHH0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHH0"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="14">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="15">
        <location>
            <begin position="547"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="16">
        <location>
            <begin position="822"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="440"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="943"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="944"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1014"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB81025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117550" checksum="0D47575D9D57ED98" modified="2018-07-18" version="1">MAEIKIDSKLFQERLSHLVTAWKNDLRSKDGLFGGASSLVIMMGKVEEVPEFHKNNAMHFWLLGYEFPTTLMLLTLDALYILTTAKKAKHLEQLKGGRFPIEVLVRGKDAAENEALFVAVTDKIKEAGKKVGVITKDTSKGPFVDEWKKVFSERCKDIEEVDISTALSTHAFSIKDESELRAMRTASKACVALMTPYFLDEMSNILDAEKKVKHSVLADKVDKKLDDAKFWKTVELPSKGKLPPDLDPSQLDWVLGPSIQSGGKYDLRFAAEPNDDFLHAGIIIAALGLRYKSYCSSIARTYLVDPNKSQESNYKLLYMVHNTIIKEIRDGMAAKDVYAKALAVIKSKKPEMEKHFLKNVGWGVGLENKDPTLVLNAKNQRVLKDGMTLIINTGFQDIENPQPQDKNSKIYSLVLTDTIRVTSSEPVVFTAEAPTSADANSFFFKDDEEAQPTPKKEKKDSRVGAVATKNITSTRLRSERTATTDEDADKKRREHQKELAAKKQKEGLARFSESTGGQNGGEVKKFKRFESYKRDNQFPPKIKNLEIVVDSKNNTVVLPIMGRPVPFHINTIKNASKSDEGEFAFLRINFLSPGQGVGRKDDQPFEDASAHFVRSLTFRSLDGDRYSEIATQISNLKRDVVKKEQEKKDMEDVVEQDKLAEIRNRRPAVLDNVYIRPAMEGKRVPGKVEIHQNGIRYQSPLNAQHRVDILFSNVKHLFFQPCQHELIVIIHIHLKDPIIVGNKKKTKDVQFYREATDIQFDETGNRKRKYRYGDEDEFEAEQEERRRRAELDRLFQGFAQKIAEAGRSENIEVDMPIRELGFNGVPFRSNVFIQPTTDCLIQVVEPPFMVITIEDIEIAHLERVQFGLKNFDMVFVFKDFTRPPYHINTIPVEFLDQVKDWLDSSDIAFTEGPLNLNWPTIMKTVNQDTHQFFVDGGWSFLQADSDDSGAEDESEEESAFEMDEDELDEASESSEEDSDFGSNASDDDDDEEADVDSEDEGEDWDELEKKAKRRDRESGLNDDEGKGGKNKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHH6</accession>
    <name>A0A2T4CHH6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1005629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHH6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="17250" checksum="7C466B511BDEE5E9" modified="2018-07-18" version="1">MGIVNNGVQAAKARRKDNPRVPPHFLITMIDQPLHQQINSPLLVVSGTSVRQTKKTPRKRNQAGTEQWAVMQQVDGRQLMEFESRFAGDVAKRPVTSADSTDTEIHNDRTKARLRELSELPKPLSSELRINEQMASSLLSAYRRWIGDGFDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHL3</accession>
    <name>A0A2T4CHL3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_75154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CHL3"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14131" checksum="D0990DCDD4D33A70" modified="2018-07-18" version="1">MTRSHKYNDRDHKGLADGSVSPTENMPRFFAKNGFVDSDPKKIKKDGSGKGNWGTAGEEVVDEDFRFTNARRRSNSFSHHNLSDFKTKFEVNEPDPLFEESVHGPVDEENGDDLSKTDSAESVHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI40</accession>
    <name>A0A2T4CI40_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI40"/>
    <dbReference type="STRING" id="983965.A0A2T4CI40"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="9"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="542" mass="61151" checksum="0200438DC3548D70" modified="2018-07-18" version="1">MGSQPPVSKRLIVCCDGTWMNSDNGYQEPSLKHPQPALQVPSNVTRISRCFKRRCDDGTLQVMSYESGVGTGSNLLDHLTGGAFGLGLSERVREAYSYLCANYIDGDEIFLVGFSRGAFTARSVAGMVGSLGLLTREGLEYFYPIFKDMENWINDKYEDEFPGQPFPNKPKGPNAADDYRARLEKLGYTRVYQENGELIKIKAVCVWDTVGSLGIPKVSWLDKIGIRPINDEYKWHDTSLSDRIEHAFQALALDETRAPFTPAVWERLPENRLTTDLRQVWFPGNHANCGGGWPDQEAADASLAWMMDQMASVGVEFDLSCLERVAQKTIGYYKSLKTAKKGPKWAVEPIYKENQPVRPWALGSINKAGDFIYKLSGFEDRTPGLYKRTDPKTDRETGIFLQDTNERIHSSARVRLACKGLGLDDKAVWTCPSLSNWQLKHTNETFIDPIPHSPSWWQGPPDESGVDKQESGRWIWEYTGPQAGAPTDPKQRIMVEEPLGPYERYLLQLLEGTPNVYLFAETQDIDWQGKKILALRSRKDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI51</accession>
    <name>A0A2T4CI51_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1321411</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI51"/>
    <dbReference type="STRING" id="983965.A0A2T4CI51"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="37"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB81202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="39899" checksum="7B87F252F4844FDC" modified="2018-07-18" version="1">MFRHTTRRLAAAAAKAAEPSAYTLAVSRAQGVARGLTGAIGNTPLIRLNRLSEETGCEILGKAEFMNPGGSVKDRAALYVVKDAEERGLLKPGGTVVEGTAGNTGIGLAHVCRSRGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHQARRHAEALDNAVWTNQFDNTANRRAHIETTGPEIWAQTDGKVDAFTCATGTAGTLAGTTRYLKEVSGGRVKSFLADPPGSVLHSYIQSGGQLTERSGSSITEGIGQGRVTDNLRPDIDLLDGSLNISDEKSIEMVYRCLDEEGLYLGASSSLNVVAAKEVAEKLGRGHVVVTMLCDGAYRYAERLFSRKWLEEKKLLGAIPKHLEKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIP8</accession>
    <name>A0A2T4CIP8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1323326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIP8"/>
    <dbReference type="STRING" id="983965.A0A2T4CIP8"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="72" mass="8105" checksum="FDDF3864F6E65FE8" modified="2018-07-18" version="1" fragment="single">MQRLLNGGDEINEVDQHGRTLLSRAAERGDEQVVEMLIKSGKADINARDQQYGETPLIWAARKGHHNIVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJD3</accession>
    <name>A0A2T4CJD3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1020270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJD3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="167" mass="19142" checksum="8E9537C51C4C8265" modified="2018-07-18" version="1">MSDSAGDGRPGNQTATKRRGEGIETFLVRYTRGFLGVNNKLERLSKRKEACYGKEGRTMHGVSLRWQSPWRWALLRYMVVILSLFLLTESGKRRRKKRGVIFEADIISWFLSKTLFIDLEGGWFRYAAYGGEVCRWDDLLRRGCDGFENKVNAPMLIMGKLSPIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJI4</accession>
    <name>A0A2T4CJI4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJI4"/>
    <dbReference type="STRING" id="983965.A0A2T4CJI4"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="15587" checksum="7CC7990D396103D1" modified="2018-07-18" version="1" fragment="single">DVVDISKDQPVYDPRGLERRGIHYHKFPTVSKVPPDGETVDQFIRLVDSIREAQRERAVAEAWEDPEQCVVGVHCHYGYNRSGYFVVCYLVERCGFALPDAIEAFKTARPNGIRHSHFLDKLYMRYNLEQGGCRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJK4</accession>
    <name>A0A2T4CJK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1323337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJK4"/>
    <dbReference type="STRING" id="983965.A0A2T4CJK4"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="455" mass="49635" checksum="3A613FE6A7805E4B" modified="2018-07-18" version="1">MAAYLTQRISHPHHGIPVSRAGTPAPEKKAKCSEPIYNVAAKNATFFTPEQIPVPGTATEHQKSGKPVPKLFTPLKIRGIQMANRIWVSPMCQYSAHEGFHTPWHITHYGGMAQRGPGLMMIEATAVQANGRITPEDSGIWLDAHVDTLKKHVDFAHSQNGLIGIQLAHAGRKASTVAPWLSSGATAVEEVGGWPDDVVGPSNEPFNENYPKPRAMSIAEIERFKHDFQIAVLRALRAGFDVIELHFAHGYLVSSFLSPAVNKRTDQYGGSFENRVRLALELVDDTRRIIPKDMPLFVRISATDWLDTNPDWNGPSWTVDESIKLAKLFAQRGVDVIDVSSGGNHPKQKVVGGPGYQAPFAKKIKAAVGDSMLVSSVGSIKTGEVAQKIIEGSDDPEDTPVDLIAAGRMFQKNPGLVWAWADDLDVSINVAHQIVWGFGGRSKKAPTDHTKLNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK07</accession>
    <name>A0A2T4CK07_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 78 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1368388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK07"/>
    <dbReference type="STRING" id="983965.A0A2T4CK07"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015538699" evidence="1">
        <location>
            <begin position="25"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="270"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="605"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="713" mass="76743" checksum="430DDB40DD8100F8" modified="2018-07-18" version="1">MAFNGLAALLTSSALLIAPSLAIAKDNTDPSWHQYVRSPVAKVVKPVGSVPESIVGNVSNPAGLIDGPGATVLSRSDEDDPLPTMVVDFGQNVVGILSLEFSGSQNATTGLPGLRLAFSETMEYLTDRSDFTRSDNANGNEKLTNGTDQVAVKATNYTWTDIHGCQEGTKICSDGLHGFRYVKIWLEALPSDAPYTSSLGSVSISDMSLEWSAYLGTPDTFSGWFECSDQELTQWWYDGVYTVDMGTDTFFANETEPRGASSPTLEGKQVLFDGAKRDRDPYVGDLAVSSLTSYLSHDFAESTRNVLEDLALHQRDDGWIPPASINNYALPLFDYPLWWVVCSVDLVMYTGNTAYADTYWNTLINVLDGYYPSHTDNMTGLLDKTADMGYGDYAFLPRSGPVTYYNALYVHALSYASQLAKSLSHDDETTRWSSRAAAVGEALLSHNFDKSVGAFYDGGPCPGGAAGTICNVHAQDGNVIAILSGVTDEKTSDAILDYWQTAASQVYGNAFYDSSVLSPGDHFDQRVYAFISFFEIAARFATPGKASSAFEEIRRLYGWMAAHDPGITMWEGIGPNGTAYEGAFTSMAHGWSTGIVPLLTGYVLGVKPQSPGFKTWKICPVVEGGGLTWARGEVPTPKGVIAVSWERKDGESGLGLVLVIETPEGSSGTVCVPTLGMESPKITLDGRPISSLPGQTLVTVDVSGGKHVFTVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK80</accession>
    <name>A0A2T4CK80_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK80"/>
    <dbReference type="STRING" id="983965.A0A2T4CK80"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="413" mass="46107" checksum="56AF02EB5FD2442A" modified="2018-07-18" version="1">MPLNAETLSQLQDSVNKACVDAKNDLPGVAVVVVGKDGSELFAHSAGKRGLVSNEPMTLESIFWIASCTKMLTGFACMQLVEQGVLKLDDGEHLEDILHELKSVKVLREDGTYEDKKNRITLRMLLTHTSGFGYTFSHERLRNWSFPVGIDEFSGRSEDVLCTPLLFQPGEAWEYGTGIDWAGLAVERASGLKLDAYMQKHILQPLGIKDMSMFPTKDMRDRLAYMHSRNPDGTLRSRDHLHRLPLIIDPDNEAEARRVFNSGGAGMFAKPQEYCKVLAVFLNDGTCPRTGTQLLRKDTVDEMFRNQVPQFPNLGRQIFFDAKPDLTNIIYDFYPVPGDPPQGWGLTFMKSNGGSTGRSKGVAHWAGLANCWWWCDREKGVAGILCTQILPFADGKVLGLWADVETRVYAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP10</accession>
    <name>A0A2T4BP10_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1059519</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="KZ679254">
        <property type="protein sequence ID" value="PTB71042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP10"/>
    <dbReference type="STRING" id="983965.A0A2T4BP10"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="49"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="19026" checksum="74625EBFF586B46E" modified="2018-07-18" version="1" fragment="single">MPLRLKPGYPHSSSSHHFFGSSSSAHRSYTDGRDQSAGYQPKARVTERYRIIGFISSGTYGRVYKAVGRTVNGEGIAVVKTSSGFTPTSGSGSSSGSNAPIEVAIKKFKPDKEGEQVSYTGISQSAIREMSLCSELRHANVIRLVEIMLEDKCIFMVFEYAEHDLLQIIHHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPN6</accession>
    <name>A0A2T4BPN6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1406667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPN6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="79" mass="9552" checksum="AFBED64370FB7495" modified="2018-07-18" version="1">MTHYFTDDHWDLLVRQPWMRFKRYDHLATSSSMTSYNRSTQCSSAQKRQPKPEERNFFFTVVNCSSTFSVFLLLQDRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPY5</accession>
    <name>A0A2T4BPY5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1406551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPY5"/>
    <dbReference type="STRING" id="983965.A0A2T4BPY5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="96076" checksum="2E6E207AC4FAD438" modified="2018-07-18" version="1">MHAPRTICSRCASQIRSIQTRSLGGAAFFASLSDANAPANASSSTTAPNINPDTHQRTAEAAKRQPHSNAWGTSKKGTRRHISRPSGFSRNKPLRPSEDSAIALFNDVVSPQAKTATSPSSSPLGELEIAAKIKDLSAKAVEPVEKLQIFRQTIWPHLEQFRGGMPKHLLLSSTLLLEKTCEEIAEHGITGHSIELSKLYSGLGRPDLDFRNKLVLNVCHALIFGKRDSAGRAALMDELIGLWKHISQLHRPSQEREPLQFSFPSPRDVRQDITESKMTNHHLDSTTRALAALFLQFGPGDARYIIPGLLTTVAVLSDPRFIRTGTYASMGPLLNLVAIILGSNRDAVTETYISRMFDEYARFPSAKSSNIKSYVLQQWPQAIEMLHNENPPWRSGSSSSLTALHIQLRSAYMARDLASMSSIWLEFKKLLETKPHLADQLRRNAEFLDFWVFVWCACRRHRHLQETFDFMQQLQIHPTLKTYTGMMHGWKLCKDTDRIEALWQKLAGSGQKLDSHIWTERISSLIEAGKPQAGIEALAEMVALWKQAVQKNAPHTAVQPTIESVNAAFKGLIQVDRKAAFEVLKWASREQIEPNVRTYNVLIRQSFRDDSPDDVQTLLKVMSQHGIDPDPATFTIILEEVIGRMGAASAADQVEAVHSVFQDIQRAGLRPNQETYGKMLYAVSSLANGTDEAIAAVFTHMRDNGFKVTPHMATILVERAVSRDPPDMKAIDTMLAEFGFSRVSDGDQTLWERVMSANAVTGNTERAMAIFNDLQKAGRPVTSLPCLADLLWALLASDKREEARHVVDVVLDYKTGDGDWDGDSKDERYWRHRFWFLAEERGLLEGRDLPDVLRANLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPY8</accession>
    <name>A0A2T4BPY8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_217588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPY8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="239" mass="26903" checksum="C499ACEB7D040DCF" modified="2018-07-18" version="1">MLPYLVGYSYCTRTQICLVLYLYRKWLCCDTVLRMYRLYNTNSMSARSTKHSVQLHNLNKNRNTSRSSSGDGFGTSGLSWENSAEQWISVSAIDKSQCRKRSRVSSQFTSRSPSNPGTIYSRNFDLIFAIHRPSSPSSMHLFFSHTPCHGPPITSDYPPANPQSRKGKTEDTNTQKPATCPEATARLNQSKCLVSFHRGSLGFHSPSEWQSVNLLIYCSVSVSIPISLPIDPYPIHPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQW0</accession>
    <name>A0A2T4BQW0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1139392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQW0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="17540" checksum="93450D2B31FE8829" modified="2018-07-18" version="1">MSLKGVSKRPNPRGSSAGTRKGKPNHRIRPSVDECGRWNRRQRAVSRGGSRHHQHGSIASLSICICAGLAPTITGKSYPQSALGQGTAATAGTLYVHFDRVCSARRLLLDRLDMANPDPASSQFSSCEQGTHPADFWTGSIRPRRLAPRGVSAATAREARVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR28</accession>
    <name>A0A2T4BR28_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1473363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR28"/>
    <dbReference type="STRING" id="983965.A0A2T4BR28"/>
    <dbReference type="OrthoDB" id="5332336at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09597">
        <property type="entry name" value="M4_TLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052759">
        <property type="entry name" value="Metalloprotease_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032475">
        <property type="entry name" value="Protealysin_N_PP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43579">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43579:SF1">
        <property type="entry name" value="NEUTRAL METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16485">
        <property type="entry name" value="PLN_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protealysin N-terminal propeptide" evidence="10">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M4" evidence="8">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M4 C-terminal" evidence="9">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="381" mass="42681" checksum="CB170DB68A638F84" modified="2018-07-18" version="1">MRCRCFIVPPHLFRAITQSPHVPEPVRKAAEASLAAHDRFAIAREVRTLQTIQDKRTKRDATVQASPFIPESVLQRLSASDAVDEASRARANRDLHHLQGLMTRAQLVDADDRVRKGAFTGATYSNVYNASNTWDDEKLPGKLGRGQGEPPVEDSDVNSAYDNVNHVLEFYEQHFYSVHFGEDYADAFWSPETKQMVFGDGNVLLRNFTGCVDIIGHELAHAVTDNTSPLDYSGQPGALNEHISDVFGIMVKQQVENETSEEADWLIGENCLLPDVKGVALRSMKEPGLAYDDERFGKDPQVDNFAQWEAFYLSAVAFGGYSWEMAGKIWWRAMNCGRVPVRCTFQQFADVTVECAEELFDVKAAMIVREAWNKVGVTRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRJ6</accession>
    <name>A0A2T4BRJ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GPI2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1385539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRJ6"/>
    <dbReference type="STRING" id="983965.A0A2T4BRJ6"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="497" mass="55069" checksum="3FA7D35D21F0C831" modified="2018-07-18" version="1">MPSPTDDETPFPRLSHATSLNSLDRSHLSPHDAFTYPLRQPFDGDGAADPLSHLRHLKDDRSRSRRRKRAWKKLMWVKQSYPDNYTDQATFLENLQRNPRLKPYDFWPLVADSTVILQHVCSVILFIVCFVGIFQERVSPVSLVSGSSFATFLGWILWERWVSEEQDKEDAPAAGGAAASATKTESIRRRARAASIRRPITAPRAMPVSSSRTTSETSSSRPSAGSSTINIKVQIPENEQLRVTSHASPSSTTSPTSPLSPRVASQNSTGADGQPLLQRASSDMMSDFPLPSETNRLHQRLGTIKSALLIYCTLLGLSPILKSLTQSTSSDSIWAMSLWLLAINIFFFDYSGGVGAKFPASLSTNAALMASTVLASRLPSTKQVFCLTLFSIEVFGLFPVFRRYVQHRSFRQHVILTVLLILGAGWGVGVVIAEPKPGCWPWKRGIGGMAVAVMIAAIATGGCSWWLIGLQRYKNEIRGPWDPARPIIMSRQRWDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS18</accession>
    <name>A0A2T4BS18_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1425941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS18"/>
    <dbReference type="OrthoDB" id="4895355at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="325" mass="35224" checksum="9EE033E900335BBF" modified="2018-07-18" version="1">MAKRGRPSLNLTPEERIQRRRLQLVASQRKRRAHKRLTLQPPQAEPKPDPAPGSLPPRPDEAELCRYYDAVFLGQDEPVALSSCSNAIAPRTKATAKAATRPTTRSTTKTSTQIATNGTWDMSCGSAPLDSISETSLASAPLAAVVGPHSRASPLQTTKPRIDTHAPSFRLEGPAVWADFTFVESGKSVISPAVFASEHMAYNVMPLLGSVLDLSVQHGADVDDSHLLGHPATRPSRILIAKDRDNVFSPGRFSTTESEWMPTNSNETPYSHRHIKPYHRRPPSPPSPDSGPASSSVEAADLAAPWAGAKQDYDLLRETVIGSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS39</accession>
    <name>A0A2T4BS39_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1473075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS39"/>
    <dbReference type="STRING" id="983965.A0A2T4BS39"/>
    <dbReference type="OrthoDB" id="4900271at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="609" mass="68535" checksum="558F9246D27B3389" modified="2018-07-18" version="1">MHPPSQPEQEAIVLLPTATVPSYFQTVVGKRSPVSDDIEEFRGLPYAHVPGRWEHSRLRDTAMTNECFDWLCRPRCPTPGQPDSSFFQSYLPFPNDREDEFECLNLLVVRPSKAALAKHGLHPKKSKLPVLVWIHGGGFADGAATSPVYEAFIMVAINYRLNIFGFGASSDMLAAQSSQATIKGVNFGLRDQKLALIWIQRNIAAFGGDADKVTIMGHSAAAISCHIHLLEAELDTKKPLFRKAFMLSGAWGGLDFRSLEKADERWADLCRLWAVRDESPIDRLNLLKRIPAKDLVRSVSDDLHWRFFVMVIDELTIRKSNLNCEVSFHFGHDEMDNQVKGPSDEPIQVVFGTASHEFSGFVRMANWDYDKFRSLLVTCFPLEAAAENVLRAYNILPTTSADELFEGFVQYISDATMCLRVHRAGSFLKAHREQQALLYGKDQKRVGVQYCHFEFGNPFLGPSDGIAHHGVELIYLFGTFREALEKADQGVLEGYIDPSQEAADVAPPPQASPSARGMKYSKSNIDLSNELQDKLIQFIVEDNEETAERANADEITTFCPDRSTRVENWTSTEKWRAREKRYEILEEDMGSMLAATRKLVGSVLDMTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSM9</accession>
    <name>A0A2T4BSM9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocation protein SEC72</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSM9"/>
    <dbReference type="STRING" id="983965.A0A2T4BSM9"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="208" mass="23348" checksum="5784049B25D493F2" modified="2018-07-18" version="1">MSDLDHFSMLPIHMDPQSKAILPSGSRPSRALAAELEKLNALHRAILNIEVPPGAIPLVPPPPIPVNPKRTAAVSKLRDGGNAEYRRQKYEEAVRLYTQGIEMALQRPLWEPAALVREEVSMLYANRAQSHMAMGNWPEGAVDAEASVEARRVGNAKGWWRRGRCLTEMGRLDEAREWVKRALEMEGEEADLVTLLKDIEERIDKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT13</accession>
    <name>A0A2T4BT13_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_157443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT13"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="103" mass="11081" checksum="5A5300E3335C7863" modified="2018-07-18" version="1">MLNAPRMLPYATNLTKANSSTAQIHHTIHANADNPHCKPSNHTSMKSPQTPKRRAPPSTDSIMHNRRRTSRDTSAHPALSAPFSIPGATSAVSTSPSISLFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTF9</accession>
    <name>A0A2T4BTF9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1405572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTF9"/>
    <dbReference type="STRING" id="983965.A0A2T4BTF9"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="334" mass="36280" checksum="FC80D7B24DB580BB" modified="2018-07-18" version="1">MDRNLECANPPNSARESRRGASPASSVPPRHGHGESPHAGPAHTSHSMSAPIDQDAAPRDEAEASTLHVRALVAAAQQQRTRRRRGSLRKVALLGRGAQRDRRDGRQLAIDTDALAAAPVSESARFGPASASGTTVHDALGLNISPVSSPTSEYPDQPNPIGSPTSPACFEPGQADMYSFTTDEEDLIQLETRASQVLRSSLPLSSGSESYYAGRVAAERRQKAKSPLSYSASTLPQPAVGWDYSETEWWGWVVLTVTWFVFVMGMGSCFDVWSWAWDVGKTPYAPPELEDDPTLPIVGYYPALITLTCVMAWVWVVVAWVGMKYFRHAKISGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU22</accession>
    <name>A0A2T4BU22_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_152543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU22"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="176" mass="19652" checksum="CED36F6495E39721" modified="2018-07-18" version="1">MYTTAVAMIATFGLTTWHDRDKFATTACLVSCPAARFAPRICPIHLLVHHPAASDCYRGFVRDFVFEEEERSLGGRHMRTSLTSSLATSHEQYIKLQQGSREENGMVDSHASRHQLVAHYAVAHKESIPPFSAREKGSSARKGDTIITKEPRHLAACIRFTIHGLRLGPHDAPKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUD5</accession>
    <name>A0A2T4BUD5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1425524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUD5"/>
    <dbReference type="STRING" id="983965.A0A2T4BUD5"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="597"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="631"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="822" mass="90690" checksum="3088081403A765CA" modified="2018-07-18" version="1">MAPSPTAVGSLLGQVVHYHLDNGSYDSALFFAERYAAQDTQSSDAAYLLSLCHLRLGDYRSAYDVSQPLGCHGVNLGCSWVFAQACLALGRFTDGISALDKAKGLWQQKNTMGKHSATTRSATPDCAAVLCLLGKLYRGYDDKKRAIDYFEEALKQNAFHWDAFKALCDMGVVLRVPNIFQASDGLLQNLGQDLTTLVNVELSQTTATLASFEHAPQKKPAPRSMTVDSGVDIFGVSFSAANMTPMTENVLANSESDFISKMQKAKLRFTNSNNNHQHEMEGLETPTGPPTEAMMSRSNNLQEPPHAQTRRTRNVDQTLEPQPRTNHRVGSRRNAATREKNNSQEQALEPIADAPGAPTGNSRSSVIQATDRKRTHTGYPVSRSANADEHATRRSTRIKSSAKSHSATPATGGIPVARELKKARPPVSRPIRPGSSGSGVPRVVSGSRRPLEDHNGDGGYGEVGKAQEATPLPVSKIAEPDTSRLEAALTWVMDLMRKLGSGYYSMSQFQCQQAVHELSLLPLAHQNSPWVLALMGRAHYEQALYADAERYFRRMREQAPSRLEDMEVYSTVLWHLKRETELSFLAHELVDAAWHSPQAWCALGNAWSLARDPEQALKCFKRATQLDPKFAYGFTLQGHEHVTNEEYDKALTAYRQAISADKRHYNAYYGIGRVQQRLGAYDKALTHFNAAHRINPNNAVLVTCIGTALEKQKQIIPALAAYRKAVELAPGAASTRYKKARALLAVGNIEEAQQELVILKNLAPDEGTVHFLLATLYRSMNERQEAVRHFTIALALDPKAGPQIKEAIESFEDDIPMDDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUJ1</accession>
    <name>A0A2T4BUJ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1404682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUJ1"/>
    <dbReference type="STRING" id="983965.A0A2T4BUJ1"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="338"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="414" mass="45030" checksum="982E4A8380C5088F" modified="2018-07-18" version="1">MGSRKDSDPPEESEQELEQQHADIDFVTFGMLILDDIDFAPPTPSRTNVLGGAGSYAALGARLFSPPPLSSTVGWIVDQGSDFPPAVTALIDSWGTGAVMRHDADRLTTRGWNGYGGGGAGDKRDFKYLTPKKRITTADLPPNLLQSKSFHLICSPTRCQELVTSIIARRKEAAPPETYTKPVFVWEPVPDLCTPDELLNLTNTLPLVDVCSPNHSELAGFMGDDGLDPVTGDISTRAIERACEQLLDSMPLQSFAIVVRAAHKGCYVVKNGGRKRRPGGGSKSTRKKNYTRGGLRPDIDMTALLADLIRDEDGLVVRDEIEVDPGVERWIPAYFKDSKEVVDPTGGGNTFLGGMAVALARGKSYEEAAVWGTVAASFAVQQVGMPTLERRDDKTETWNGSVVLDRLHEFEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUR5</accession>
    <name>A0A2T4BUR5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1404713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUR5"/>
    <dbReference type="STRING" id="983965.A0A2T4BUR5"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="64"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="469" mass="51334" checksum="A1153CEED112AFA1" modified="2018-07-18" version="1">MAVSTGYIGLFLEDHGEENQRTFDPRDSRAHRHVPVDQLIVYNAHKGVRQLQEMNAYTGQMSVDSRTVVVSIDGACRGNGTPSAQAAWGVYFGPQSMHNECGLLDATLPQTSTRAEIEALSQALNIIRNYVSEDYSLLHYHIRTDSSYLVNTFSTWIHDWIKNGGMNSRGKRAAHFEVLKRIEERLDDMTYGDDGGMTFRFWLVPRGENKEADALANQALDEGSRANILATSAKLQVLAISPLDQASGSNKMAANVKPRVLAVSLNRLSFFDSMYDSLLSKLRADSTFQRVEDGPSAIRMLLEEPRPDAVLVTDEALTLKKNAAVWDAVLKYIRRGGTAVCMGHFSCFTSPMSIKPFFAKAGLDWSSASYHRTTLVLNAQAVGTSLASRLPPAYSQKAVFLKQAKPSDAWYVTNKDSVLESLVFGAENAHTPGESPVLLARVAGGKLGYVGDVNGEEGSEAVVLAMCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV14</accession>
    <name>A0A2T4BV14_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1394349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV14"/>
    <dbReference type="OrthoDB" id="3545167at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="14251" checksum="9C22B7D5D51D786C" modified="2018-07-18" version="1">MIDNLQCQTHTRTPWGSSPHRYDPRIRSLAMGLLCASVLAVFTVSLVFVGNSAVKAYSSSSSPSEDDDDHPTVSTGEPFSTEQVTSTTTNVGASKVNQSTTRSITTVTITGLQTLLPTTITVPFDDFYTTDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV69</accession>
    <name>A0A2T4BV69_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1465233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV69"/>
    <dbReference type="STRING" id="983965.A0A2T4BV69"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="703" mass="77491" checksum="0698BBF020D1AB6B" modified="2018-07-18" version="1">MATKDMAAYIKSLSTPPAPGAPHGVAIPGSERPGRTAIYRHHKIGDGKLLTTFNPEIQSVHDVFEAAVKKRPSKRCLGTRHWNASTQSWQETYEWETYAEVAERRKNLGAGLVEIHQSIGHTLDKYPVGLWSQNRAEWQITDLALASQALFTVSLYDTLGPDTSEYIINHAELACVVCSLPHIPTLLKMAPRIPGLKLIVSLDELEQGEQKGLTKAAVLNDIASQHGIKIYSMKQVEEIGAKSGRPMRPAGWDDICTINYTSGTTGAPKGVVITHGNAVSAISSSRLQGAVTEKDIHISYLPLAHIYGRMVDQVALSEGASIGFFRGDILGLVDDMKILKPTGFISVPRLFNRFNSAIRTATIEAEGTKGALSRQVIATKKASMRLPPGKAHNKHFLYDRIWTPKVRAAVGLDRAHTMISGSAQLDPDVQEFLRAAFGNNFYQGFGMTETYAVGTVQLPGDFSLGNIGPPTGCVEVCLESVPEFEYTVDDKPNPRGELLMRGPCIFREYYKNEEETKKAMEPDGWFHTGDIAEIDKMGRLKIIDRKKNVLKLSQGEYISPERIENVYLGNTNLIAMAFVHGDPKESTLVGVFGIDLENFPPFASKVLGETVTAADIPALKAAANHPKVKAEFLKVLNKIAQKQKFNSFERVRNVYLDVDPFTIDNELLTPTLKLKRPQAAKAFRAQIDKMYEEINAEVGPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV71</accession>
    <name>A0A2T4BV71_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex, subunit 15/MND2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1340652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV71"/>
    <dbReference type="STRING" id="983965.A0A2T4BV71"/>
    <dbReference type="OrthoDB" id="5320532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43173" checksum="D37980FBCBA553FE" modified="2018-07-18" version="1">MFATLPDFTPRDSHSLWYSSSRNPFIPPGPVDNLHADPNHNHHGPAHSRQRGQLMERTLLARLAADEQKMNRRRLNVQNFGSTWLKPPGVPKTLNQMREEKREQEEHQEAMRREQLAQELAEAEGGGPMDEGMMDDVQLDGAQDLDDEIPDADDAFDPSSDEDEEGGGEEDEENEEDEDDDDEEEAMREEEADEEALREERQHGLVAARMRMTDDAFREALIRGDPEADGSLYGGDEDLGEEDREQMLDEDDLYDNTLDDGTAGDMDADLDDDIPEADDGGYEHTDSEAEVSSSARSVRVHEQDDDDEEDEGEGDTTDTHDLSFMPSRAAPLGTPQSPTMPRHAGFPSGARASLDLSGLLSQDESSLLMMMESSPAVTTRRRAGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVH9</accession>
    <name>A0A2T4BVH9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1059913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVH9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="12349" checksum="B477DCE2A686C9CC" modified="2018-07-18" version="1">MGDHTLGHRGCKFGRFVANQAALKKCDRMKASWRLCRMNGSYEAKDSKAESLRPLSKTPDKAAPHVTPSLSTKLCDWPTPPALSISSATAVPPNATPVVFLRLVPIEGTLKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVN1</accession>
    <name>A0A2T4BVN1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal fungal transcription regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1441016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVN1"/>
    <dbReference type="STRING" id="983965.A0A2T4BVN1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="240"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="613" mass="70901" checksum="3C7136413A56B4E2" modified="2018-07-18" version="1">MPNRSSLDRQRPLRHVLPAPSKQPPVAATPAPAPAPRPRQMVPAACNSCRRQKTKTTSQALKRGYQDLRRRTNVHEELFELLRNLPDREAEQVFNRIRDGADVDTILNLVRAGNLLLQMAVTPETRFRYDFPYRSEMPDYYLGNNPYLDSIIYGAASLYAQDRKPDATAAGRPGDHATDGYDSIYLKPFHAAEVVDPRLTDAKISWWTSVSSDNVLMRELLGVFLRCEYIFTSAFQKDYFLDDLVARRKDLCSSLLVNVALAYSCVCFPRFSNRAEYWNPDTLVYRFLAEAKRLWELEKDEPRITTIQAGILFNVFHNLCGLDEIGQPYRLQAIELARQMRLFETTVTKRSERMQKSMAFLAWTLFNWETLVAFSFMVLPVIKEPPNWTLPDPAKETEFYGEIWLKYPLTQTLSPSYFGQVFRSKSQFRVIMHDFCMTAYSEDSQVTVEKAYELRQRLKSCIYYHHFLLTIFEPLVDTETPQKPSPKAIVAESRRQLQTLIRLYYLRHGYDAMDLFIVIPLMLAASECVEAIDDKTTGQDLEVLRSTLILVAKGLYDQRRNHYLAEALFRVVRGRMRPSEVALLRGSMSIDDKEWEEKQDMVQAVRTPPPEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVS9</accession>
    <name>A0A2T4BVS9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_7141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVS9"/>
    <dbReference type="STRING" id="983965.A0A2T4BVS9"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="141" mass="15546" checksum="AB2542CDA0B87CF4" modified="2018-07-18" version="1" fragment="single">PDWPAKVKALTPRSRGVDIVFDPVGLVDKSTKCIAWNGRILVVGFAAGAIEKVAMNKVLLKNISLVGIHWGAYSVHERETIPRVWEGIMRLVREGKIRGTEYTDEEFVGLDRVKDALLALGGRGTWGKVVIKIPQEGSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVT8</accession>
    <name>A0A2T4BVT8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_21669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVT8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVT8"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF11">
        <property type="entry name" value="TINC (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015653930" evidence="2">
        <location>
            <begin position="26"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="946" mass="105643" checksum="5301D824D72DD6EC" modified="2018-07-18" version="1">MIDFRAPGFLLGLVLLVCLVQPAAAFGAGNIASVSKVEGQNWRHGDIEDALLSLAMAQAIKGGRKFNKRTVARVYFGNWLRDYSQAIDVATVKMVSAEAIRLLLCVLGFMSFGYGSGEFEVTAERLGCYRPEDHIDNPKGYAEGLDARDFDPRLRGPVDENVELAIDPETGMKNYIANERAGCMTSSRHVRNLFGRCIELGRRYRRSGNKPELYEALRLMGTGLHCLEDFFAHSNYVELALIEMGERDVFPHVGRNTQIELEGARHPVYPITTGTFGGVDFLHSVTGEVSDKLTQNEIDELEGALNEGKSGDTSLLQSLLNNLPPGILGNNNQGEKLDEIQHNAAAAQEETEPVSPRDPEEFTIYVQKIYKQIMPVIEFHDSIMKSISGAIENIPILPKVIEQLEEQLSIFVFSIIAPFIVPLIHQIRNELQTGSSEIIESSKKEQHIVFDDDYSSDPTHSMLSKDHFSNILNEIAGRTAARMLHWVVPQLMEAIDDDSVDVDRLLERIVTGVMHHPAQREMGHDGAAEARQLIFNSVQEWWSSMGEEQQEDYRRKLSPRGVMDGENHKEGVHDTGHGCAGKLKMRKEFGEPQGVEDQIAGAAANAIFSGATDALSGFVSQNAGIDLPSSRHEESSGGDPISGLISGMAGSLLGGAFERGSTERETSYETGRDGSYTQRQTEYGQQGDRYGQAEYSQTYRPDGGRESEYRRTEQQESYGGGYGGSSYEERRETHESSYGSYEQRTERREYRSTEESYGGDYSRRRSGSRGSNESRKEHHSHSHSHSHSHSHSHKHKHKHKHHKSSDSDDDSEKGYGDREESSRHQSSYERRDEDSYGSGGYGRREEDNYGSSGYGRRDEDSYGSGGYGRRDEDSYGSGGYGRREEDSYGSGGYGRREEDSYGGEYGSREEGGHGRRHGHRRDDDDEAEDDEYRSRDRGGNSGGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWA8</accession>
    <name>A0A2T4BWA8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1066426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWA8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="104" mass="11690" checksum="C5FAF64D74E6A327" modified="2018-07-18" version="1">MPTLYTLCTYAQKESERATERESVPAYMQTGPTDRLRTHALRLPSIHPSNAQQGLLPKDTHRGCAHQPRRAKRPGRSLRHKQQLSGYLAGCLERQTSAGIRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWI8</accession>
    <name>A0A2T4BWI8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_136770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWI8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="16433" checksum="8BBC4C5282D36375" modified="2018-07-18" version="1">MFNDEINCERDCKCLMNLFWVCIVLHSTVVRAQVTSARICSVLCLPFFHHFTRSSHVIRSHLRIQLSNTTILYSHRTSSVHALLTRSAHWHGTRGHPSANVCRGTVPTRSASKPGGGCCAGTGPGTTSPMQSAPEAKSPRPVTILALTAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWL7</accession>
    <name>A0A2T4BWL7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-terminal binuclear Zn cluster-containing/DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1360496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWL7"/>
    <dbReference type="STRING" id="983965.A0A2T4BWL7"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="764" mass="85070" checksum="B3C6018B6A12BB2A" modified="2018-07-18" version="1">MAASSASPVLLRRPNGRPVACDNCRARKVACDHRQPVCRRCEDRGQQAECVYTSSLPRKGPFTSNRRASPRAAGRSAGLLSTSQREDDAGAAAPRPAGTGPEARLGAAEEHRSLRRAEARRQASVEIHGGRATKGHSFESSSSPLNPHAPRRRDVGASATTTPGGHLASERASSPLHQAPGYLGFTSYSSVFEETKNSLSMLQGFHAWLPQPISDGLRQGADELSRCLYSPTREMCLVVLRAIPAPNTCYIELVRESPFYRDGWQRVMARRVLADLHERFGSYLGPCRVDSQLEEIALFLSDNTTRPFHELEPDPEKWIGQFTGPNLRWESLGFVFSFHDMVFPDGDKAHGGLDSKSAHKEWIEISRVCLGLCMDLSRRFASANGLLAQLSHRRATLESMHAGDASYSCWRTTAEAVALVTFLGMHAESNSPSYEPTLASESRRRLFAQLFVGEKDGVLFTGRPPRLSHRYAFTPLPLDLRDEDLLVGGEALKRAVAELDENGWNTGGKIYSATVTRARCIVAMIRDELVEIGIGKPRQKVASALLRDLKERQIEAVKEFPPSLAYNPSEILDPDSNINLIFARLLLQLEQLQNFFFVDRLLLKHGELDDGGLLLIAFQLVSLTLLFWTHKDRFAPFRNDFEWLVMAFATPSGGILCMELLNPTFKGSYHPKDPSITRSNIIQQLSLLIAFLEWIDPSRPNGDMCMAASAVMRRVLDHVLNTASEGLSWRPEERDDVQLDFSFELFDTFDWMKYDGVGNQGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX04</accession>
    <name>A0A2T4BX04_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1404061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX04"/>
    <dbReference type="STRING" id="983965.A0A2T4BX04"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="314" mass="34224" checksum="7AC73F073F00F9C4" modified="2018-07-18" version="1">MSSPPIKKVCLVGANGTLGSVLLAALLQANCFDVSILQRSTSSSSSSASPSIRRIVVSPDLAVDELTTALAGQDAVIAAFPLGQGDQHLRLAEASFNAGVRRFIPADFGSCDAADPKPQEYLPLYRRKTLVRERCEELAARPGSAFTWTALVCGHFFDHGLRHGLLHFDFATRTAQILDGGNARASASTLRRIAEATVRVLQRAEQTANRRLYVQSFNPTQREILAALEKAMGERWTAREVDSEAYLEDARKRLDSDDGEAVLVAVEDIVFVLGALDADWTKREGFAMELLGLEDERLEDVVGEVVAAYRAEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXE1</accession>
    <name>A0A2T4BXE1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1304620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXE1"/>
    <dbReference type="STRING" id="983965.A0A2T4BXE1"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="87" mass="9889" checksum="33DD54C791CF978D" modified="2018-07-18" version="1" fragment="single">AGLFPIAARFNHACFPVNNVEYRFDEENRALEMVVRRDVAAGRELKISYGNNLSPELLYSCYGFRCGCGGCEGLSERDVELFESMQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXZ6</accession>
    <name>A0A2T4BXZ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1337943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXZ6"/>
    <dbReference type="STRING" id="983965.A0A2T4BXZ6"/>
    <dbReference type="OrthoDB" id="5350192at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="156"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="469" mass="50371" checksum="4AF750B605755B35" modified="2018-07-18" version="1">MALRERISSPLEAGPSLLDAHHIAPHLLPVLEYTSGRLARKSIHLTLIIVKRDYQLLNSPISSPSSSSSSSPQQQLPARLAFSSLKHLMRSASQHVVGSPRSAGGSPASSSSSYPCTEPASSPRFRWPLSPAFPSSPPPMTPSTTSSLTTTESNGSTMTSNSAGLRCFHSGDLSPRTEKVLKSTLIKAGNKFGVGSGWLVPLTSPSTRDLTTQLYHSSVVQNEVLFSSDGLSLLTLDRLYSIKSALSSYSKSNSPPRLEDAVDELRRYVLATNGAKVPRADLVRSYDWLGVSASAIADLDRMYRRAYGGPDRVGGIAGMPSSSFLSPSSTILDDGIVKVAMTAVKFSRPPTPRRIGPPLKLQTDFSPKPTSPVEPDKPAEVPKIEEPDEQVHTARPVDRSMASVWNTRFTIDQMLSPNSNTDLQPHSPAIGPMTPHGYDDISPVTRGEWGFLMGGNGLNIGKTAAVETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY46</accession>
    <name>A0A2T4BY46_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1403556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY46"/>
    <dbReference type="STRING" id="983965.A0A2T4BY46"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="507" mass="57793" checksum="5959C315C8C55520" modified="2018-07-18" version="1">MLRISCRFRSCFDRSPGKFVLFVAVTIVLCYAFGNVARDAAIDTVYAQLHINESLRDILRTSKYYQRHPITPPYKDQFWETGQRSRNLSRWITDLDGPWGSELTENERKMLVSAIETTASSLFPFLNPAPGKKGSQTPLRDLRRSFTKGSRGIVIPAGGSELQIRFTGHLISTLRDVFGCSLPIELAYAGDGDLPEYRRDALLSLDKTNNTRLLNVWTVFDDTTLRLRRKGWAIKPFAALASKFEHVIVVDADAVFLQSPEVLFEQRAYVDNGAYLFHDRLLWQHAFQGRHDWWRDQIKEPSAAMNKSLVWTDDYAEECDSGVVVLDKSRTEVLVGLLHIAWQNSNDVRDEVSYKMTYGDKETWWLGLELAGSRYEFEKHYGSIVGWEKEGEGESKAVCSFVIAHTDEGDRLLWYNGSLLKNKLVDAHGYEVPLYWMMDGEWEKGGKKEMSCMVKGERRWLGGDEISVLQRSIEAAIRVDEALARAEAEYQAKIKAEAEAEVEADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYI6</accession>
    <name>A0A2T4BYI6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1337716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYI6"/>
    <dbReference type="STRING" id="983965.A0A2T4BYI6"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="60"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="478" mass="51241" checksum="5EB234420AC3F1F4" modified="2018-07-18" version="1">MRSVQYISLAGLFAAATVSAGVVTVPFEKRNLNPEHALSLLRRDGSVSLDAINNLTGGGYYAQFSVGTPPQKLSFLLDTGSSDTWVNSVTTDLCTDELTQQTVGEYCFRQFNPRRSSSYKSSTEVFDITYLDGRRIRGNYFKDTVTINDASITGQQLGLALQSVRGTGILGLGFRDNEASDTKYPTVVENLVSQKVIPVPAFSLYLNDLQTSQGILLFGGVDTDKFHGGIATLPLQSLPPSIAKTQDIVMYSVNLDGFSASDVDTPDVSAKAVLDSGSTITLLPDAVVQEIFDEYDVLNIQGLPIPLVDCAKAKTKDATFNFKFDGKTIKVPIDEMVLNNLAAASDQLLSDPTLSKFFKGWSGVCTFGMSSTKTYGIESDEFVLLGDTFLRSAYVVYDLQNKQIGIAQATLNSTTSSIVEFKAGSKTIPGPASTGDDDSDDSSDDSDEDSAGAAIRPTFSIALAGTLFMAVSMMMSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYK4</accession>
    <name>A0A2T4BYK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1311685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYK4"/>
    <dbReference type="OrthoDB" id="10571863at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="108" mass="11627" checksum="3D2CDFEDAF11F3C5" modified="2018-07-18" version="1" fragment="single">RSCCALHAHLPPLTTSGIWPLPVGAECSAAKMVALPLANPSSLTTKQFHCIVRWRCSGTEPMMTSLDPARPVSTQPNRRARSSFLGLLEAVASPTRESTLDFGKLQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYQ1</accession>
    <name>A0A2T4BYQ1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1337953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYQ1"/>
    <dbReference type="STRING" id="983965.A0A2T4BYQ1"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="125"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="603"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="771"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="846"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="864" mass="95909" checksum="E2BD9E8C598435A0" modified="2018-07-18" version="1">MKEFPRKFLSLRDKSGEHHRSKSAPPANKARPLSAEAFRAIFKPDHARQTHLNELEAAREASKVEDIQRSLDRLGITDVTVEHIRDILATKFANGDPERTVQFIDIEQKASSGVIIPYDPSVHMVGAENRSAVTCYIDALLFAMFSKLDAFECMLKNDFPLDDPRNKLVTLLRIWVNMLRSGKLIHTDLTKVIQDTMAECGWSDARLLEQQDTSEAFAFLTEKLELPLLSLQVDLYHQGKQDKDDHKIVYERLLNLAVPSDPDGNGVKLEDCLEEYFNTQVDVLRDSEEAKKADADAANPSLSPKLMLPVQIQLVRDGETTATPTALASSPLEMSPANLLAQTLVEQDEDKNQEEEAKVGEQSTGEARAPKAKAASSSNPLRTRSASVIQRVLLDDQGRPTSSDNIARRKRTSMKGSTVVRAVTIPAWQFFRLIPWHAVKSTEPQSNVEVAMNFDQRPVVGICLKRYAMTESGRPQRHNTYIDIPESMRLPHFMLADGPHIEEETNGLATEYKLVLQSVICHRGDSLQSGHYIAFARVAPKLLTGNRKHAIDPPPDYEEAQWVKFDDLEIGNRVTFVEDIKESLKVEMPYLLFYQIVPMVDPPGPSTDSTAGGPPSYDESRTSASTQALATHHEHKASASTQALVTHHEHPPSASTGRLGQSKPPSIRLSAEVERPSRKWLEGISMNFGGPYGETAMSRRPSYALTDSAAQSPAITPDTQSPAMAPVDEPTSSRLSRAASRFNLGKQSRPASQSGEGRISLNLSRFGGLIKTSKEPLPEPPALNISSANSTGQRSPQPGSPTSLEKQLQPSGTEMYDKSDKPEKHEKTDKADKSEKHKHRRKKSKEKNEKQKSGDQPERECVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ81</accession>
    <name>A0A2T4BZ81_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indoleamine 2,3-dioxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1423639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ81"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ81"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55693" checksum="D2BEA7C22B96177E" modified="2018-07-18" version="1">MGSIPTSTPPFEVLTDARPDDNSLPAFLVSTTRGFLPRADPIATLPKEFEPLESILQRMPVKTLSGEPGLLAHSKLGDEVDTKFPDLTDEMEKYKDNLPLMNALYRDYSFLASAYLLEPCHERFLRGESYGLGRQTLPKNIARPIARCAELTGFMPFMEYAGSYALYNYRLEDPSKGLEYDNIRLIRAFEHGLDPTSSEAGFVLVHIDMVRNSGPLVAATVRCLEEASKTSSGLGSIEQRRSFNEGLSDIVTAMKKINAVMETMWGKSRPRDYTSFRTFIFGITAQSMFPNGVVYEGLYDNKPMSFRGESGANDSMVPLMDNFLQLPMPDTPLTAILNDFREYRPSNHKAFLQYVKGRSADLDLKAYALGYKGEPESDEHEELLRESRSLWIQILNEVRDFRWRHWCFAREYILKQTSHPTATGGSPIVTWLPNQLEAVLKEMVDVHERTKAKHKNGLGSVAEGIMEAALRQRDTLRKEVDKFCAERGVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZF3</accession>
    <name>A0A2T4BZF3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_99946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZF3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="145" mass="15583" checksum="D147740A4CF4FFE4" modified="2018-07-18" version="1">MTRSRPGRSAAHIVLCAPSIRAARSRLMLAPTLELLPCQRDSQASRLQALGKSSEFPANEQPGARLSLKRFGLINGQEAAVAGRQFSGPSSSGLAGSTPSTLKVFPETCVEISRTLPSSVEMMAARRTRGCQRLTIAYLVAYHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZK4</accession>
    <name>A0A2T4BZK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1034538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZK4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="119" mass="12517" checksum="56F4DDE7D052EBC1" modified="2018-07-18" version="1">MGLLGGLWCRRSAAAIGIAALGVAPGIALTACAALPDLYLSGHLLPFTSYFQLVRLGCDKIRPFHKYLVASGCDNDNKSPGHSHPASVPPPASPSGQTLLRLLASRRNPSPFMPRLVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZR7</accession>
    <name>A0A2T4BZR7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1403247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZR7"/>
    <dbReference type="STRING" id="983965.A0A2T4BZR7"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="560" mass="62923" checksum="68E9B5A266366591" modified="2018-07-18" version="1">MDQAISTIGIDPHPQKSRRSKTGCYTCRIKKVKCDEARPRCERCVRLRRLCDYEPKMKHNDLLAISRGYMLALESSKSLPTWARRAALTRALALPARLPAFPGSASSLNLTSADHEAIRYFRTTFARIHHTKNPDYSLFSIIFTLAQGEPMVMHALLALGGHEIEFRRSSTSDESDGSSQLVERNREKWTPVQHYSAALGLLADVIGNADDGRQLELDPICAVLYLMLVYEQKYGDGSCSGLSNHLAGAALIVKHRCQRLSEQIAKRGWQGTPVLSRTQPQSQIQEPGLSLFVIRLLVWIALCDATAATFGLGGQFNSELKGIMGPDDASSITGFDVLHRYSNSLYRSMWGETYPQVELLDDVENRDIFAFLCASMQLRSMVADLARLDPAQFNLRLPAVDSAFRQVDLRYGELLEVASNLSLSTNNSHRLVANIRAFIPIYHAAKLDLLRVIRRNGVTTRMEIVPEAHITAIIDLAIQADKHQGVEGTIRVAWPLFVVALETNSVVHQRWILTRFQTMSSYSKNLERAHRFLKEYLEMPFEKRGDCQSFSLANGEIFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZV8</accession>
    <name>A0A2T4BZV8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1761-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZV8"/>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="15767" checksum="651AFCD29B66D235" modified="2018-07-18" version="1">MSLQYFPAVKPSAIALGTAFNHGVDLVVLAPIFGQTYHRAKAANTKEEFIHSREASGAAVAWGTSFVGSALQSYGVGALLNATGTLSHKGAAYLGALIFAATSAPTFLTQIFSEKRPLDTVGVNIAAKLLETIGLSLVLNWWGTRTNPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C071</accession>
    <name>A0A2T4C071_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1440277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C071"/>
    <dbReference type="STRING" id="983965.A0A2T4C071"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52285" checksum="E57C6DB9C3478D6C" modified="2018-07-18" version="1">MVYPGDSASVDNVSRNCELNWLGCSETFGTAHDSPFALVEHFAANKYFHALPGYYKDVVTGLWNCDTENAEFPSSLRWHRTWTVQEAVLPAKAVAIYGTWRTSGESFDLCEGYRLEHLANYSGECCGKSYEAVGSSRGFPMDQVMGCVASMKRSRRGAPGYRTFFDISFAFMNRQCFDPRDKIYSLLGFAGSAGASIYPDYTKEVSEVYTEAFRAMMEENDMSPRCLLGEGFNSHRFNLPSWVRDFSAVFDSKFQHGRAQGAYNLFKACGHKLGKLKWMDGKTLLAKGVLIDRVKAVATCVPYSQPSNMKEILDDWRRTCEDNGVKVSTEQRDEVFARVLCGEITEQGFGQKLLEEDDIDLSNDTEWSVFLASGNARALPRKYRVAIKSTIDRKVLYVTSSRRVGLSSPTITVGDEVWVVHGSNVPFILRRQPGTGNQHHLVGETYLFGVMHGGCAGEDGSSEDLFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C075</accession>
    <name>A0A2T4C075_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1403455</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C075"/>
    <dbReference type="STRING" id="983965.A0A2T4C075"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000084">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="19">
        <location>
            <begin position="35"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="16">
        <location>
            <begin position="248"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="18">
        <location>
            <begin position="748"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="17">
        <location>
            <begin position="856"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB74968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="938" mass="104400" checksum="391A8342C295F675" modified="2018-07-18" version="1">MGLNLPGKTLGAGVTLCVQLAAAAHNVIDLSQQKWTLTSPDFENITVAGKVPSHAHVDLYEANIISDPLIELNDFDLRWIGNSNWTYTSEIQGLQTSNDLASYLVFNGLDTYAAVEFCGEHVGNADNQFRQWVFDISKVLASCTAAHPQLTVKFGATPNISATIAAEPGQETWPDGINEVYEIPNRWFVRKEQSDFGWDWGPAFVPVGIWQPAYLVQLGGPSSVYVKNSAFDLYRKGQLNNLPPDQTADWIFNASVDVVGTVPDGAQMRFTIVDSDSLEEVSSGSLSDIENGGDVITGIATLDPSQYELWWPNGLGAQKLYNVTVDVISDNETIASVNKRMGFRTIVLNMEPISDLELSQGIINGSNFHFEVNGHVFYAKGSNFVPPDPFWPRVTFEHIQEILTDVVDANQNMLRVWSSGAYSPDFMYDLADEMGILLWCEFEFSVSLYPVDSAFLENVRQEAVYQVRRANHHPSLALWAGGNEMEKDELPAVKSRAPSQYERYLSEYLLLFLDTLLPTVYGNSHSISYMPCSTNNGYLELNFSLPIPFVDRLYNTTPGYLYGDSDYYDYDPSHAFDINKYVVGRFANEFGFPSMPSLETWREAIPEDQLFFNSTMTVLRNHHYPPGSLTTNNTADPLRGMGEMTRGVQQWYPTPAKTDTVANFAAWCHSTQIFQADFYHTKIQYYRAGSGMPQRQLGSLYWQLNDIWQAPTWSTREYDGRWKVTFYATKDIFQPVIIAPVFNVTTGVLEMFAVSDLWSDISGEASWEWIGYDGKPVGDSDASVQSQKFTVGPVNSTVLARINITELTTSGGLPASNAVLIANITATGTSPNTEGTKTYSHSNYFTATPLSKAKLIDPGLNIRHDGDAFTVTAEKGVSAFTWIALDPNDAAAIVTFDDNGFWLRQGQSKTIGYRVRGESSGWESRVTVSSIWNNTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C093</accession>
    <name>A0A2T4C093_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1357743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C093"/>
    <dbReference type="STRING" id="983965.A0A2T4C093"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="323" mass="35988" checksum="190F7F3CC5818665" modified="2018-07-18" version="1">MSYEAISLAIGSHTWTPENKEVDGLLEVMRNHNIKVIDTARSYGLGASETVIGLKKLSREFAIDTKAATGVIPGAGQKILQFAKESLEALQTSKVRVFFIHAPDEETPVHVQMEAIQTLYKQGAFEAFGVSNFTPEQVIEFYDYAKSKGYVLPTVYQSSYSLAVRGNETRLFPTLRKLGISIQAYSPMAGGLLSKTREYIESGQGNWNPNTSTGQIFRDLYYKPSYLKMLEEFARLSQDTGLSRSGLAYRWVRYHSALQPEHGDSMILGSVTAQQLEEALMELNKGPLDAAVVEKLDSYWQLIKDDAPVDNLISVRKVVRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0D6</accession>
    <name>A0A2T4C0D6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1378902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0D6"/>
    <dbReference type="STRING" id="983965.A0A2T4C0D6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="61127" checksum="535487BC72E1DCF5" modified="2018-07-18" version="1">MDSVWTYAKGPNLAAPRVQSLMQEVIKELTRKSGLHLLGIFVGMFITWRVAVAFYNVWFHPLSKFPGPPHMAAFYLPYMYDTFICGNMHNTIRKLHQKYGPIVRVGPDHLAIDGSVGWPEVYGQKTGQEEFGKVPEFLFQGDTTALIAAPKDVHRRQRRQLAHAFSDSALRAQEGVMKQYVDLLMSRFAERADTGESFNIIKWFDFTTFDIIGHLYHSEPFHCLENNGYHPWVSAFFKGIRGDSYRRFLRHFPLAHEIVKRLRVLSDLNSSTDNRDYIMEKAQARIKQGDFAIEGYRDFIAFMLKKNRDGEFGFFEPEILASSPLVITAGSETTASSLSALVFYLGSNPVPYKRLTEEIRSAFSDEEEITLNSTQRLEYLHACIEEVLRVYPPVPETPPRQSPGGTIDGKWVPRGTTLTVFQMATYHNPKHWAEADSYLPERWLPKSHPLYDDKFKDDNRATFKPFSYGPRDCLGKNLAYSEMRLILARLLFGFDFELVPGQEGWHDALRTFLVWERMPLNIHLKKRSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Q2</accession>
    <name>A0A2T4C0Q2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Q2"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="11447" checksum="7422CDB9F9ECBAA7" modified="2018-07-18" version="1">MSFSASAQNFWLEDGHILRASVADEEGNYQESSIDLDQFIGNEDGWFMWDGVNFSHSANDIRLEGTTLTAELPMRDGGYRERQGVNLDDRISNQNGRLVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1A9</accession>
    <name>A0A2T4C1A9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1335528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1A9"/>
    <dbReference type="OrthoDB" id="4898648at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="8598" checksum="C6B9AD2278BAF564" modified="2018-07-18" version="1" fragment="single">SMVSSAGGASSAVDAIGAATASRHGAEGIVASSTALSPPQEDDVTDPAAKVLQNEMDKEDVSSPALNKKRERNMWIAVRAFTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1E1</accession>
    <name>A0A2T4C1E1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1379580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1E1"/>
    <dbReference type="STRING" id="983965.A0A2T4C1E1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="84108" checksum="B279258B5F9C2E36" modified="2018-07-18" version="1">MSGMVNCAACLRRAVQASSRSRPLAEAAGFWASLPQTGRRYASVAAPSTERTDAPRTLTLEPLDPAESKKKDFERLQRIVKKQLQHMDDPWKIAQYVEAALAKDRFDEALLLTKTAGKDRQVVVAWNHLINYLLGKQQLKNAIKLYNDMKKRGQLPNVQTYTIIFRGCAQSQHPKLAVAEAVKHYNILLSDKRLQPNSIHMNAVLNVCARAGDLDSMFLIAETANDTTRAPTSYTYTTILNALRHQAIRDMKDVTPEQEAANAQKAVDRAKTIWSEVIDKWRKAQLVIDEELVCAMGRVLLLAPDREEKREVLDLLYQTMSIPNLAKDPGADAFQDGQMEKIAVSGVAKRVPSSKAVYAVPGRNTLALILTTLASSRLTTSGIKYWNLLVRHYGIVPDNDNWLRMFGMLKVAKASSHASSILSLMPDEYIDGKHYRIAMETCVRDNINTNALDNAKRVLDSMLTRLPVPDIHTLRLYLRVALVSHYQFRERMKKGDEEGAKRDYGLQITTALAHLWEPYKRVHYHFFKESAKGSKLSPGELYNSQREVIALARHMFSAFNKVINEKMLPEDDAKELRVVGAKINREIQKFYSNREEREPNLRKSDSGVTNEAADEGNDESSFDAGFRPGADFVWNTTRQAGEIDERQPRRQWGAQEGDERPSRTWDDRKSDEGRPRRSWGAKDSGERQPRRPWGAKDSGDRQPRRSWGAREGDERQAGRQWGVKEGDEREPRRQWKAGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1R3</accession>
    <name>A0A2T4C1R3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1256028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1R3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="201" mass="22068" checksum="7116DC49EFF3241F" modified="2018-07-18" version="1">MQVGAIRTHKLPCPAAPPHDASAAGPERGSKWWLYRISTSEHRQTGAIVNRIKTIEARDAVCACESWLYGKSTPPTSSHCRCEHLDQLSSRSVSCIMSRTSMYRHGCSMSPRPERRTYWTGSLECCASALPAMRSAARGHSCVCRPDEEPAGVCMCMYHNSCESDESSPWRGLTMDARIRARAASAPPGHAHAHAMPCHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1U9</accession>
    <name>A0A2T4C1U9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1392091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C1U9"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="220"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="1393"/>
            <end position="1709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1812" mass="203838" checksum="3D3788AA0514011B" modified="2018-07-18" version="1">MHELNFRSSSNAWGYFSVGTQGGIHSFSDSQFGHIFAYGENRQASRKHMVIALKELSIRGDFRTTVEYLIKLLETEAFEENTISTGWLDELISKRLTAERPDTMLAVVCGAITKAHIKSEALLAEYRAGLEKGQVPSKEILKTVFTIDFIYEGFRYKFTATRASLDTYHLFINGSKCSVGVRALSDGGLLILLDGHSHNVYWKEEVGATRLSVDSKTCLLEQENDPTQLRTPSPGKLVKYSVENGSHIKAGQTFAEVEVMKMYMPLVAQEDGIVQLIKQPGATLEAGDILGILALDDPSRVKQAQAFVGQLPAYGDPVVVGTKPAQRFALYHNVLVNILNGFDNSVIMADTLKKLIEVLRDPELPYSEWNAQFAALHARMPQKLDSQFTQIVERARGRNGEFPAKALSKAFSKFLEENVEPSDAALLKTTLAPLTQVLDAYAEGQKVRELNVINGLLEAYFEVEKLFQSRAQEDSVILGLRDQNKDSLAKVVQIVLSHSRVSSKNSLVLAILEEYRPNKPNVGNINKYLRESLRKLTELSSRATSKVSLKAREIMIQCSLPSLEERTSQMEHILRSSVVESRYGESGWDHREPSLDVIKEVVDSKYTVFDVLTSFFAHDDPWVSLAALEVYVRRAYRAYVLQQIEYHNDESDNPLYLSWDFRLRKIGHTEFGVPVESAAPSTPGTPIESEPNVKRINSISDMSYLTSKWDNGPSRKGIIVPVKYIDDAEDMLQKALETLTFYNQQRRQSNTSGLLADLSGKRKPFAALRKEFQSRNNGDELSAVINVAVRDAESRDDAEILSRILPIVQQLKSELLIRGVRRLTFICGHSDCSYPGYYTFRGPDYEEDDSIRHSEPALSFQLELARLANFRIKPMFTENKNIHVYEAVGKTVESDKRYFTRAVIRPGRLRDEIPTAEYLISEADRVINDIFDALEIIGNNNSDLNHIFMNFTPVFQLDPATVEQSLQGFLDRFGARAWRLRVAQVEIRIVCTDPKSGIPYPLRVTITNTSGYVVDVDLYAERKSDKGDWVFHSIGGTKDKGPLHLLPVSTPYATKNWLQPKRYKAHLMGTQYVYDFPELFRQAIQNSWVKAVKKQPALASKQPKVGDCITFTELVLDDKDNLDEVNREPGTNTCGMVGWIIKARTPEYPAGRRFIIVANDITYNIGSFGPKEDDFFYKCTQLARKLGIPRIYLSANSGARLGLANELMPHFKVAWNDASKPEGGFRYLYLDEKTKELFKDDVITEEVVEDGEKRYKIVTIIGREDGLGVECLRGSGLIAGATSQAYNDIFTITLVTCRSVGIGAYLVRLGQRAVQIEGQPIILTGAPAINNLLGREVYSSNLQLGGTQIMYRNGVSHMTANDDFEGVSKIVEWMAFVPEKRGGPVPVSPSLDGWDRDITFCPPQRQPYDVRWMIAGKQDDDGSFQTGLFDKDSFVEALGGWARTVVVGRARLGGIPMGVIAVETRSVENITPADPANPDSIEQITNEAGGVWYPNSAFKTAQAINDFNNGEQLPLMILANWRGFSGGQRDMYNEVLKYGSFIVDALVKYEQPIFVYIPPFGELRGGSWVVVDPSINPTAMEMYADTEARGGVLEPDGMIGIKYRKDKQLETMARLDPTYASLKKKLQDKTLSAEDMESVKQQISIREKQLLPIYSQIAVQFADLHDRAGRMKAKGVIRDSLDWVNARRYFYWRLRRRLNEEYILKRMNPSFLPAPALNTAKAREARSQGLKLLESWSGIAGWDRKDQEVAEWYEKEAQSIGQKVEALKADKLAAEVSEVVRSNEKAGWKGIREVLRVMPVEEREAVLKYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2P5</accession>
    <name>A0A2T4C2P5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2P5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="66" mass="7376" checksum="E23FBD12683005FD" modified="2018-07-18" version="1">MVGCIRSSSHVEKQPQNESGETDAIWARQRLSTPPAAVQGFPSIPSPEKRTDRVSFPHKYSELQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Z6</accession>
    <name>A0A2T4C2Z6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_363366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Z6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="75" mass="8007" checksum="5BD17C1D8F51D0E5" modified="2018-07-18" version="1">MEGSERVLLSPFVLLLSACSWHVQVCWRVVGTGATQSFSRVGQSMQCCFDCIACYIVLLSAVSGQQAPEAAHGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C307</accession>
    <name>A0A2T4C307_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1357522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C307"/>
    <dbReference type="STRING" id="983965.A0A2T4C307"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="66"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="221"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="836"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB75905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114862" checksum="57C5078800AF1C77" modified="2018-07-18" version="1">MATTSVPKAMEALTISKTKELKGTEKRDSLIAVEKKYQKKWQEDGVFETNAPTTAEVPFHSISPAELREKQPKFFGTMAYPYMNGTLHAGHTFSATKVEFAAGTARMQGKRALFPMGFHCTGMPIKACADKLVNEIKMFGEDFSGYKEDESVIEEQPKPAAKQTKEDPTKFSTNKSKANAKTVKMKYQFQIMQAIGIPTEEIHKFADSQYWLQYFPPLAIRDLTSFGARIDWRRSFVTTDANPYYDAFVRWQMNRLKELNKIKFGKRYTIYSIKDGQPCMDHDRAEGEAVGPQEYTALKLKVLEWSPKAAETIKGKIPEGANVFLVPATLRPETMYGQTCCFVGPKLTYGLFKVDDNNYFVITERAARNMAYQGIFAKEGSVEKAADIQGSDLVGTLVNAPLSLHKEGVRVLPMETVLPTKGTGVVTSVPSDSPDDFATVTELAKKADYYGIQKEWAELEIYPIIETPSYGDLCAPFLVKKLKIASPKDTKQLEEAKELAYKEGFYQGILKVGDFKGEKVETAKPKVRSQLIEAGEAFAYSEPERKVVSRSGDECIVSLMDQWYLDYGEQSWKETALKWVENADGKGLETWAPETKNGFEGVLNWLNQWACARSFGLGSKLPWDPQFLVESLSDSTIYMAYYTVAHYLHKDLFGRTKGLGNVGPEQMTDEVWDAIFCRRDLSDDVVASSGIPRATLESMRREFEYFYPLDLRSSGKDLIPNHLTFFLYIHLAIFPPEYWPRGVRANGHLMLNGEKMAKSTGNFMTLKDMVEKYGADASRIALADAGDGVSDANFEEDVADNNILRLFTLREWCEEMVKEQNELRTGEINNFQDGLFNNEMNACAREAIEQYTLTNYKLALKAALYELTSARDFYREACAAGGIKMHKDLVFRYIELQALLMAVIAPHWAEHIWLEVLKKESTIHNARFPEVPAVDAALSAKREYVRSTASNMAFDEKETLVQMLPGLKRTSGLSVCEVLVVEEGGKKGVRLEDGQEVEIGVPVAENAVPGQPTFFFENVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C345</accession>
    <name>A0A2T4C345_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1402480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C345"/>
    <dbReference type="STRING" id="983965.A0A2T4C345"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="84"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="251" mass="27882" checksum="74D18EF08A9C00CE" modified="2018-07-18" version="1">MLKRSLLRSNNKNRIVKHLSSSSPKTTSTTSIATRHFSTAPKMAFFQRNFYPETSFTPLFRLLQDFDDYSRQTNGGSQSGRRSGGIAPWQPKFDVRETNAAYELHGELPGMSKDNVNIEFTDSQTLVVHGRVERTYTAGTPPAGALEGSKSGGAITEGGEKDKKPPKPTVEDEEAANKEQQVSKKGEEKDNKPADNAKYWLSERSVGEFSRTFSFPTRIDQDKVSANFKDGILNITIPKAAKHEPKRIAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3H1</accession>
    <name>A0A2T4C3H1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1244931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3H1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="15920" checksum="4779C50FA7CD2961" modified="2018-07-18" version="1">MQPPSPCPPRLTYQQPHHHRTDKRPNRRPAASCQLTHASSLPTARASATSTSTSTGAPAQEHQHPDGSLLYKLQYKQMLPTRTWGSSEPAPLPRERPGCKSRRSKCECDLIFLQFFVTFWCFFRQRCQLGRDRDVDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3V6</accession>
    <name>A0A2T4C3V6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1438962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3V6"/>
    <dbReference type="STRING" id="983965.A0A2T4C3V6"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="465" mass="51015" checksum="A5B2D2CF034A0500" modified="2018-07-18" version="1">MTLTVLSDDQVRDILETLSLDELEDFRKTLADALHAFSTDLGADGLGVFQQPHRISTLHPETQATTLYMPSCGPTGMGCKVVSLTSAEASKDPSVQPISPTGVVNLFAPDGKPIGLLHASTLTAFRTALASLCLVYRRNHVKTITVFGSGMQAYWHVRLALMMRGKTVKHVNIINHRFSDSAGRILKKFTIIPHDIKVREGWDGAKFSILTPTFHDYERLQKEYIRAADIIYCCTPSQQELFDASILTNREGRKKGRLIVAVGSYTPQMRELPEGLLQLVTKPREKGHRHFHKHADEGGVIVVDTLEGALTEAGEIIHAKIAPTQLVELGELVMLHRMAVDESESESSDVMSQTSSAFSDLDMSERAPSMSMSTTSSDMPASPTSPLSTTSSGTRSSFSKHFRKNSSNLSDKDKQKQKDDGLSRWLRDGTVVYKSVGVGLMDLVVGTKLVEVAKQKGVGTQIEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3W7</accession>
    <name>A0A2T4C3W7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1438971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3W7"/>
    <dbReference type="OrthoDB" id="4889166at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015623348" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="192"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="340" mass="36589" checksum="A12342DDC4E84042" modified="2018-07-18" version="1">MRSILAYVLALLGSRTTLEEPVGVPGLIFSAEYQNEVFNRSASFHPNFSLNTPAGIQANGQLVVPDVDLFFGGTTGLGRAAFIQALAFDPSGGLRAQFLDRLIIVEGNIAMLLSANRITSNSSDAHIETSLAETMIFDKEPLLTRIVSISEGGLAAAQGAGQVAAPPLQNIALNPIANKTSDFTFKIKEKAAQFVTNFNSGNASANGLLATDNVTVVSDGRNSTGRASLVNLFTRYNTSVPDLLLHDEFVIAQGNWAATEYIFQGTRNGTFTMVNGTRVAPNRAQYRARGMRFMRFNDDGLVDLFWQVADNDAFVNPLSLLNPLATLNTVAPECIAQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C406</accession>
    <name>A0A2T4C406_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">M440DRAFT_1401743</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C406"/>
    <dbReference type="STRING" id="983965.A0A2T4C406"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="145"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PTB76296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="242" mass="25961" checksum="A9FFADB97CDD7196" modified="2018-07-18" version="1">MPPTTQPLPHAPRLCLRSATAATKPAAVRALSSTAACQAGGGDAPAAYSSPFKLKGDSKASQVPDFGKYMSKGNETTNKLFSYFMVGTMGAITAAGAKSTVQEFLVNMSASADVLAMAKVEVDLNTIPEGKNVIIKWRGKPVFIRHRTQDEIEQANKVNVASLRDPQADEDRVKRPEWLVMLGVCTHLGCVPIGEAGDYGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYDFPEDGKLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C436</accession>
    <name>A0A2T4C436_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cis-golgi transport protein particle complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1377315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C436"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24965">
        <property type="entry name" value="TRS130_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="117"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="262"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1343"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="679"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1544" mass="169365" checksum="3BD443E04F96AC4E" modified="2018-07-18" version="1">MDQQTSTSTVTVEYFDPHDVFKLLAPGLVPRLPLHNLNWQSHSGPLRSIDTLHVELIRGNLEVPEATLSPAGRRSGSISRGSDGLRSRSVSVSTESGRAPPSLRSKASGNLRRHQIPGLRRTPYLKMLLVRCDDNDSYKNSVRAEVREWIKVHTTPATTSKKGSGQENHDAFEWLIVHVVIPNTVASTQPRSSGRSDSAEKSTASRWRPGTTPLLEKLRADFNATTKGSQDHVAQIRIGINDVPYDLLPRVVPAVPTGYTETELDAENAWNDLIAKMKSLILASFDMRVTQYEEDIREKDAQRTLPGWNFCTFFILKEGLARGFESVGLVEDALVGYDELSVGLDTILHEQLESGQPERHGGEMLAYTEGLREMAEKALEITAEYSSDGGSDAESKTLKAKGPNFDQIAISSTAKAYRDMILANKVSVFDFRCYIFSRQIALLLRLGHALSSKEELIAMLKSQQESILYGEAPLAPPPPNHKDEPENLTTFAEICQRTLQFIPSVSQILRRDVILGLTASKTPSRKPQKLSPLVEETVDNMVASFAFSVAQQILAQTSTKALPIPPSSLSYGDGLEQKSSIPEPKTMIHPARNSSLSPRSGGIPPTPLSPGFFPGPGRQFPTDDEAQGAKTFLKNGLESLAARRAELYMLSRSILSSLGKKRGWSDGWDEAPLVGGIGFDNMEDVDLNDDDKADGEGEGDGAEGSPSPKETYTPSMAGIDNPVLRTAIDNTDDFYRLYEILTDKAMRHFTVANHDHAVHSSMADLAVLKVYLKDYKAASSYFSLTTPFFGESGWSLLELSMLIMYCQCLDEINPKGEHVGVALKLLTKYCAAEKERLQKKSGLIRFSQSKTYPEAWPVTGIVEKLTRLAKSLSKEVKVPLENFLTDVELDGFPVYDDNHDGCSLNISLRSLLPEEISFDSARLRITAVDEGPSRERLFEAAAGSPIILTPGKNKIRVSCRSVASGRYKVDRLVLSTKNLVLHFERDVKHASSSTTDIFKHADVMLFQRKSAFDFTMSATKQTSLDKNNSIDLVIHTGWNSLKSCEIRVKPATGGLRFLTTEAAFVDSSMQFAKPPEAGVFHFDAIEANKAVTIRFPYSVEQDVADIFAKIEATYVTDADETFSLAKSLVVHVALALGVNVQDVFKHEALFSRFNVSTASASPLRLYKSELLKSDLFDSVFGVPSSSPVFIFPKQPASLLYKVKRIPGAKPSKKGGGRTMYLKLDYTSLEAEMEELVRRSLTEALETTALTQYTKHVVATAWRELKSKMVPRDLEQATLMGEIMTTSLRDVVWERHFAGIGGAPGVGERAAQELSAFLRSWQKANSRLVIPREGAVDPSSILIPVEIPALPVLHTADIRLQSSIPSPFKDGTSAGLPTVCTNQMLPATLHLKWTRIWDADAAARSDQEFSYEVTAPADTWLLGGRRKGHFVIPGPSASSPAETMTSSAETEAEIPLILIPLREGWLPYPLVEIREVVNPDGDGAAAAAAAVALPCEVDLRNLGETVRVVGDRSGMTVSLDASGPGGGPLVFESERLPGFRGKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4J8</accession>
    <name>A0A2T4C4J8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">M440DRAFT_1401944</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4J8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4J8"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="73"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="186"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="293"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="PTB76496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="448" mass="48234" checksum="8178BBAB2A168B2F" modified="2018-07-18" version="1">MSSSFTRTLRPALRASSRTLAQRSSAIAGIVRPAASSNVVLRRTLSSTSPRSSASAIDISDIPPTPITHLSEIETAMTESVAKFAADVVLPKAREMDEAEAMDPALVEQMFEQGLMGIEIPEEYGGAGMNFTAAIIAIEELARADPSVSVMCDVHNTLCNTALLKWGSEHVKRTFLPRLATDTVASFCLSEPVSGSDAFAMATRATETPDGFVLNGSKMWITNSVEAGVFLVFANLDPSKGYKGITAFVVEKGTPGFSIAKKEKKLGIRASSTCVLNFDDVAVPKENLLGERGQGYKYAISILNEGRIGIAAQMTGLALGAWENAARYAWNDRRQFGSLIGEFQGMQHQMAQAYTDIAAARALVYNAARKKEAGQDFIKDAAMAKLYASQVAGRVSSLAVEWMGGMGFVREGLAEKYFRDSKIGAIYEGTSNIQLNTIAKILQKEYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C563</accession>
    <name>A0A2T4C563_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1391238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C563"/>
    <dbReference type="OrthoDB" id="10504739at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="186" mass="19745" checksum="0E86B4B6688AB87F" modified="2018-07-18" version="1">MCRTRAAEKAEMLQPVAPKDGSPRKLDSPMPDEPSGPAAVQQPAEFAQPSPCMIARARAYLQGHRARTCPHPVVTGRQRLEHGSAVEIVASASPTRASLRDDSGPACFGFTGAKYRPEALIECTSPCFKELLLLMMRGIQAMVPIRLISQFLHGLSLAPGRQTHATASTAGSTEPSSAGVVVEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5B2</accession>
    <name>A0A2T4C5B2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1391279</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5B2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5B2"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="398"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="464" mass="52807" checksum="A115A9F1DBBE1C0F" modified="2018-07-18" version="1">MNNPHDYLISSPPSAPPRRPIDPDNADSWVMLNQGGFVKLNNERILWKLDGRISCELSVPPELKARCVPFHRKSDKGALFLTNKRVIYLPAKPTQEPKFESFSAPILKFQDSTTSSSMWWGWIWKSDCIPVSGGGIPPEIPRVEVKLTFSDGGMTEFNEAYIGLRERLFQYREMRRELDASTEVPDEPLPAYEAQGDRQEPPASSQLAVPGPNRSDSSASRRAPNEPPPNYDEAQAQQLSNRLEDHIRNEVDRGAADDDWMRRANQNASIAREKRQFLFPREFGRKLACLLPDSAHHPYDFRPQTQPNDDASTFATMGIWDAFSEIVEAVTPWAVVEAEAPAEEPQGLREKLERRGEAPEAKVEEKEESKEEEPAAEEEPEEEEEEEEEEDDEEEIKDPKEELEEECKNSPQCSPAKHHFDECVERVHQQESEGEAKEDCVEEFFHLAHCATACAAPKLWSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5H8</accession>
    <name>A0A2T4C5H8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1331882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C5H8"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001345">
        <property type="entry name" value="Related to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1036"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1108"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1180"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="460"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1244"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1602" mass="173624" checksum="EE262926A8543F9B" modified="2018-07-18" version="1">MALYTQIWALTEKTLRIILTRHVASAIHSALVLPIILTLYIGIGEKFTQPNDKFGIGSPANILSLEAALSKANGGRDTVVFVNSGHTGGDIERIIDSLSDTVKGAGKNATTIQDESDLGYICRGTIRGTSDCYGAVVFYSSPDEGSDGFWNYTLRADAGLGNSFRTDKGNNDAQVYALPLQRAVDAAIAGLTPGTSFPETTQQYPYTELTEDEHQAEVRRKYQSSFIKYLSVTLIIGLIGVCYHMPGFVATEREKGMSQLIDAMMPTRQGWHRQFARLISSHHAFTIAYMPGWIVASIVARTTIWTNTSFGILIVFFILGGVAITSMSLLGASFFKKAQLSGVVTSVTWIALSIVAQVVPRPSTAAVAILSLLFTPCNFVYFVIYIARFEQDAKATDLIHAPSSGTSRLPGIVHWIFFIIQIIVYPLAAAFVERTLHGVSTGTRASTALGNPADGVQETVRIENMTKIYKPTLLRKFFSFVSPPRPEVVAVNNLTLTAKRGEILALLGANGSGKSTTLDAIAGINDFTSGNISVDTSGGLGYAPQQNVLWDELTVEEHIRLFSRIKNPLNKTPDTEIAALIDAIGLRAKANAWSKTLSGGQKRKLQLGMMLVGGSSVCCVDEVSSGIDPLSRRKIWDILLKERGSRTFIMTTHFLDEADLLADNIAIMSKGKLRAEGSSAQLKDTYGAGYRIHVLNPRSLNEVPDIEGVTKKVGTNSVTYLSSSSGQAAKVIRVLEASGLSYRTSSPTIEDVFLHLAEEVHGDGSERQPNVVTEKVSKVASDTPMASENLTLLTGRQIGMIQQTGVLLRKRFTVFKTNWLPYAAAFLVPIVAAAVIQLLVRNDTLVGCSPIQRSSHASNDDFFKLLDTAHLVGGPSSQVGDSAVEGLFKPVLPSSGTSRRRDSSAFFGNITVDLVDSLSSMKDFVEKNRRIVTPAGLWFGDSNSVPTLAFKTDNSSMYSAVLGQNFLNTILANTTIATSYREFDYPVAPSTGRGLQLVVYFAVACSIFPGLFGLYPNVERLKNVRSLQYSSGVRTLPVWVAHVIFDFGIILLPMILLATILIVSSDSWYHGGYLFPIFIFYGLTTIIVSYLFSLLCASPMATYAMTSVVQSIGFAVYVIAYLFILTLSPAAYTDRNVLIAHWIIAAIFPTGSLVRALMVGQNIFSTTCDNDRLQPNPAAMTAYGGPLLYLILQAVFWFSIVVWIESGAGRYTPEKAKPSPEVDDPEITEELVRVDNPDGPSDGLRVVHLTKAFGKNTAVDNITFGVDHGEVFALLGPNGAGKSTTISLIRGDIAPSRNGGDVFVEGVSITKHRAAARAKLGVCPQFDAIDNMTVREHLRHYSRLRGIPDVDHQVPAVLLAVGLEAYADVMAHTLSGGNKRKLSLGIALTGNPPVILLDEPSSGLDAAAKRIMWRTLEAIVPGRSILLTTHSMEEADALATRAGIMARRMLALGSTDTLRHRFGDTLHVHLVAATAPHSSAEEMNALRAWVLNNFPGAEVEQETYHGQMRFSMPSSAVPLLPVGAGAEARAGAADESESARGRLLIMLEEQKGYLGVAHYSVSPTTLNEVFLNIVGKHDVQEEGYTATDGEKKPWWKSSIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C645</accession>
    <name>A0A2T4C645_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C645"/>
    <dbReference type="STRING" id="983965.A0A2T4C645"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="241" mass="27836" checksum="CA7FACC829449530" modified="2018-07-18" version="1">MSPGTYTLLDIPTKEPRVCWSMNTWRTRLLLNYKGLNYKTEWVEYPDIEPRLKPHVPPNAEGRRYQLPAIQLPDGSYVMDSYKIADVINEKHPEPKLPLNTPVQLRFTPLLVNFMTQLRPLFVPLVAQRLLGQASLPYFHATREEDVGMSLEEYGKTHGPGAFDRAEPFARQITALLNETPSGPYFMGDTVSYTDIMWAGILLFYKRLGDEEYEEVLRRTGDAEAHIRFLDAMSPWTKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C675</accession>
    <name>A0A2T4C675_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1355487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C675"/>
    <dbReference type="STRING" id="983965.A0A2T4C675"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="57763" checksum="3D9653293C46885E" modified="2018-07-18" version="1">MACIRLSCQHRFRRVALHACSSSISRSSIVVCTSSLNSPLVLATSAYLVPIRMGSVGAYLVTFAEYLPDPCGNTAGCTCTTMLLEILLLSGLYGRVPVAAASITVPVDPDVDPLPLSAAGTVTSASELLRQSCPEEFPPRTPYSPELLMSSFADFGSDDSDAFANGTIYMSSDSLVRGAIEAWGQHQSLILRPDEVWFEILAQLNFYMTAHAEDVRHLFVDHEGKEEIQVWRLSWRDVIAAFGGEIQKRVKTDWLLDWIMPGFSTSDDNDGLTATVLMMGLMQHYFEFSGGIICGLPEVTLLGERDDWVKLLEKLDRLKEWGEEPADYAERLRPILTRFVGTWDEPDSDATKDFWKNIVRSQRLVSCGTGPADYSISGWITGFLHWTVEGNLRISREAEQEFVPSDRDVVLDGVPYFSTPLDDVPVGYAKAPLWFLFGPVNASVETGPWYGNGGELARAAAGLGMCETNTGTGSGTGDDAGGLIGDIGDGDGSLPVLDGDDDDDDGVGFDDGDVIPWYGGEGGWKKTEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C761</accession>
    <name>A0A2T4C761_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C761"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015667326" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8577" checksum="B559141ABF56F8B3" modified="2018-07-18" version="1">MSKLCPATGLLLVHRVALSLTSWHHLLSGALLCENGQQHVKVNYVDDGFHRILLLPAEGTEPETASMSSVGTHAAQCWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7G1</accession>
    <name>A0A2T4C7G1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1214202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7G1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7G1"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="339" mass="38273" checksum="534229D8620CA787" modified="2018-07-18" version="1">MTKKTESGVKLERPQKDNRQSGRSHDENRERAFIAASRRRDRDLDARLKSALDASEIHKKRTGKALRITREIVENEEMYEEEEPELHRRKVLGVPSLPGGSLPDPGKRLCELIASSDEEWRQSAINMLFARSFPKYEQQAQTMNTQTLSTPWYQPQPVMQHMPMQPSEMVSSPDVQRHFSLPVISTSHMVERTPSLPVQSPWMDRASHIAPSSPPQAPPPLAMGHTPEGSPEGRTPETTQMTGLMHTPPSPQFMDLYSQSLDSGRNTPSVETLADFDFSPTTETDKYSSESPITPDDLIYLNPAQLHTLSQVQTTCACDPAWNQTCKACKNDWDPLPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8S9</accession>
    <name>A0A2T4C8S9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1400898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8S9"/>
    <dbReference type="STRING" id="983965.A0A2T4C8S9"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="193"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="512" mass="55576" checksum="2199296E9727234D" modified="2018-07-18" version="1">MSTAAVSTPVKTPKGLAAEGRIPLTPSPIKALNFKTKKPSLRQKTSKTTVNQGGDRFIPNRAASSAIANTGSSKANLPDKKKKKRSNPSISEGSMESASPENEDASAALEGLSILDDEDDDGYSRPSPNTVAYQDSLADVCGVSLKTRILEFKPAPPESSKPVDLRQQYNRPLRTAASGQARRRIATAPERVLDAPGLIDDYYLNLLDWSSGNQVAIGLERSVYVWSADEGSVNCLMETTPDTYVSSVKWSEDGAYVGIGLGTGEVQIWDVAESQKIRSMFGHDTRVGVMGWSKHLLSTGSRSGLVFNHDVRIAKHKIAELVSHTSEVCGLEWRADGAQLATGGNDNLVSIWDARSLTVPKFTKANHKAAVKALAWCPWNTNLLATGGGSYDRHIHFWNSTTGARVNSIDTGSQVTSLRWSPHHREIVSSSGFPDNTLSVWSYPTLVRNIEFPAHESRVLHSCLSPDGQMLATAAADESLKFWKIFEKRAPTSATASATSRKADMAKHMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Z4</accession>
    <name>A0A2T4C8Z4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1399219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Z4"/>
    <dbReference type="STRING" id="983965.A0A2T4C8Z4"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="358"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="506" mass="55273" checksum="6A755A41626F9496" modified="2018-07-18" version="1">MAEPIAETRPVEDAESAPAVEKPSADETVQDAAPEEPEANAEEEEEAEAQPVPEADDDEVDDDIKSKKVTLADLSAKGTALYAQKKYEAAADIFSRASILQAEINGETAPENAEILFHYGRSLFKVGQSKSDVLGGSAPVEKKTKANPSSAKKAAKEEKVTQEGEAQAGGEGKEKKSEDKATDIPEGKKVFFQFTGDENFDESDEDEAQEGDEDEEEDDDLATAFEILDLARVCYLKQLEKLQEEEAQSDGDADKGKGKEVAKEDSPAVRHIKERLAETHDCLAEISLENERYPNAIEDGRTSLNYKMELYPEESEIIAEAHYKLSLALEFASLTVADDEGKNTKREEIDQGLRDEAIKEMELAIKSFKLKMQAIEVEIASSASPEDNELSRKAVEEMKEVIVDLEQRLVDLRKDPLSASELLGDANPLGGILGAAFGQSAADVQARVEEASKNAKDLTGLVRKKKAKVDDADAANGNGKRKADDDESTELETKRTKVEGEEQAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C907</accession>
    <name>A0A2T4C907_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1329129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C907"/>
    <dbReference type="STRING" id="983965.A0A2T4C907"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="47655" checksum="3097CADBFC84483D" modified="2018-07-18" version="1">MPTAWLARVRRLNAHNLTTFRDAPLAEISGSLGDLGTLLPLMIALAAKGYIDLGSTLVFSGFFNVLTGVVFGIPLPVQPMKAIAAAAISARENPSMGVVVAAGQWVGAAVLVMSITGLLRGAVAFVPIPVVKGIQLGAGLSLIIGAGSSLLQPLGWIHPALDNRTWALVAFFVLILTQNMPRFPYALTFFLLALVLALIQVSLAHQSLPWFHVWQPHFVLPSWFGNGDAPALWMAIGQLPLTTLNSIVAVSALAADLLPDLPTPSVTSIGLSVALMNLTGTWFGAMPVCHGAGGLAAQFRFGARSGASVILLGLLKIALGLLFGETLVNLLKQYPKGLLGVMVVAAGLELAKVGHTLNQGAPDLWHASVGQDHTEGLRQHRSLSDEERLERWTVMLVTTAGLLAFRNDAVGFLAGMLCHSSYRLSERFLSWKNRRSILSSERTPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9C2</accession>
    <name>A0A2T4C9C2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1437172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9C2"/>
    <dbReference type="STRING" id="983965.A0A2T4C9C2"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25169" checksum="6DA5B277194F0B81" modified="2018-07-18" version="1">MLDIDWKGLALPFAYLIVLGGALMTFSTIYRRRKAAESANLAPWFGPHLQRDIYLSLLHLDPEEGAEKAPKVPDGVLRAALLRRAVEDIERLIHIKTAKQACGALLQRGSVGDDLWQRFLRAEKEMEEELRDVVTEANALAPNWGPIIFQSAHEIAANTKLRQRLEEIQSQTEAEKAWWLKKRSQIQAEFMKELDESEKSSTKDGHEDDAVVVDSPSKKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAE2</accession>
    <name>A0A2T4CAE2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1195719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CAE2"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="34"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="510"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="1234"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="853"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="962"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="967"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1301" mass="142717" checksum="0DD272003ED9FA28" modified="2018-07-18" version="1">MPHPPSERKGSLTLAMDHDRSAGNGKLGTVSGVYVPVCLNILSILMFLRFGQILGQVGFIGILGLLLAAYCIDLLTVLSLSAIASNGEVKGGGAYYMISRSLGPEFGGSIGILFYLAQALNTAMNIVGLIDCLRLNLGPILPQGYWSGYGLQTAALIVCTGLCLLGSSAFTRASNALLIILTVAIMSIPVSAVFKAPFEDATAGIKFTGISIDTLLGNFAPRPSEGGYEGIKTFRSLFGVLFPATSGIFAGASMSGDLRNPSKAIPNGTLWATLTTFIVYFIVIISMAAATTRESFLANDNVISLTSLYAPLILAGECAVTFFSALMGVIGSAKLFQALARDKLLPGLSLFGRGSRSGDEPFFAIFLTYCIAQVALFADLNQIATLISMGYQMTFFVMNLACFLLKIGSAPNFRPSFTLFSAETAFLGSLTSAAAMFFIDETYASTAICALVLVFLLIHYLCPPKHWGDVSQNLIYHQVRKYLLRLKPEHIKFWRPQIILLVNNPRRQAKLIQFCNSLKKGSLYILGHVIVTDDFHSGVHEAKLQQAAWTRYISEFSKIKAFVQLTMSPSINWGIRNLILSSGLGGMRPNIAIMGFYNMEDLRRSSHRLRVPDIPMAPALQMNRPPKSQGKAARRRRGDTSAQMLKGFLPTDAIRTEDMMSPSEYMTALEDLALVYRLNVAVAYGFDSLETPRKDGSNTKKYIDLWPIQMSAEVSAEGRSMLTSNFDTYTLILQLGHILRSVHDWKRVYTPRVMVFVEYESEVEEEMARVQTLLEKLRIDAEVRVFWLASGQLDTYERIINGRGSSLDCEIVVGDALRDEEWWNDLEDFRGKSEPMTTSQEFSHMVHILTSTAGRPGVYNPHEEPESQRRRSSLVGVPGMSKRPNIGSLSKMGINIGMHTHHLNQEVFAETDSEWESGSDTETMDMGGSVINPSFPEMSSSNIPQAPSSPLKTGRKDSLGLAAGSGYYTNGNGQDTPSYGTMSTSRGLPQTHSRQESVVTPAFRRIPEVDLDATPRANNRQRSSFKIDIKSIESFPNLDQLAIPGSQQNNSQSSGSTKSENRYSGDDDTSTPRPGLSRQSSAARFSSRPVPEMRITTDETGSRIGFATTNSSSPVTPKTDRPAWSRQSSVGKSSSTQPLSGSRSHRGGGVRAITYTEQPTYCSRSSTQMQSRYRASQPRRESHASPLDQGDVSLNMPELEQSYRSDRDASYVDGAPYSTQSVALSFNDLPSRAQHLILNELMRQNSKNSAVLLTTLPIPVEGTYRDTDRTIQYLSDVELLCHDLPPTLLVLSNNMTVTVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAL8</accession>
    <name>A0A2T4CAL8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1420672</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAL8"/>
    <dbReference type="STRING" id="983965.A0A2T4CAL8"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB78590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18652" checksum="CE27F0E78DFD5646" modified="2018-07-18" version="1">MAQSTAQRRLLQEYRALTNNPPEGITAGPVSEDDLLHWECLIQGPEGTPFEGGVFPAELKFPKDYPLAPPTMKFLADVFHPNVYPSGLVCISILHPPGDDPNHYEHASERWSPIQSVEKILISVMSMLAEPNDESPANVEAAKMWRERRDEYEKTVRDGVLRMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB51</accession>
    <name>A0A2T4CB51_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1399895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB51"/>
    <dbReference type="STRING" id="983965.A0A2T4CB51"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF7">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="572" mass="62343" checksum="AB36D5F52574787E" modified="2018-07-18" version="1">MVSASEPQASRLSAYLSRLNPVPAFPEYTGPYKVGTIDVEIPVSDLPSPAPRPDNAGDVETVLFRVFYPAVATSTEKLISWLPAPQRHYVSAYTKFMGVGHTLAELLSFLPRHLHYTSIPAHKNAALESATADNQRWPTMIFSHGLGGSRNSYSYVAGALASHGVVVFCPEHRDGSAVTSLVRVPGQSGRPSRRVIPYNRISHDVSPEVYEAREAQLRIRLWELGLLHEAILAMDAGQELNNLNTSTTSLTQFVGHLHVHEPGSIIFAGHSFGATTVYQFLKSTYYARAPEVAAMEKPLFVPAEDSSIRKQVTEKNVTMLLDMWCLPLLAPNSAPLYKLPLPVYADVPSAPGGTALLAVESEAFFKWSEHLHATARLLSADPSAKVVTPAVFERPSGNKLPEPNFFYVASSAHLSQSDFGILFPLLTKKIFNAVEPERALRLNLRAQLQLLRANGVPVARTWIGDLVDGGYVDKLDPAKKSSSEDVAADGVNDDKAIFDRSGTGLVDHWVWIDTIGLGEEPQEQVGGGESTTEKIEKSEEQMKGELEPSEQVAEAAPLKGVTLPQGQGWQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBB0</accession>
    <name>A0A2T4CBB0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1202295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="4">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBB0"/>
    <dbReference type="STRING" id="983965.A0A2T4CBB0"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="110"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="221" mass="24475" checksum="DAC2FF9FE16ABB86" modified="2018-07-18" version="1">MASIACSLRAVRPVVMRFTPRAAPVVRMAPLRSFSSSRMSMFEPSMPLLLRLPPPDSRFLSSYFQRNMSQSQLRNLAWHMKANQTPFHTGLARKYTKDHEWIDLSADRKTGVIGISEYAAEQLGDVVYVELPPASGEWTEQGDSIGAVESVKSASDINAPVRCKVTHTNALLEEKPATINQVPEDDSAGGGWIVKVEVDEEGAKQFDELMDAAAYKEFVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBN7</accession>
    <name>A0A2T4CBN7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBN7"/>
    <dbReference type="OrthoDB" id="4829551at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="351" mass="38987" checksum="ECF1374E021415D2" modified="2018-07-18" version="1">MSPSALRELGMSLEYVRPDPKRTRDGYMEPRVRNVAIGSATAHRSHRKHRSSPSTRRHRGSEEDEVVYHHSSSHRSSRELDSALAQASVSSRGTSQDLAVRPRRVRTHQLPSPPPEDFQYRRGQVELVPRALGAHTSQDLQGFGAWCEPIASSQQQVSAGSSYNYEDAPQSTRSRRDSICIAPSTPRDRLLPTPDLSPLPTHFVFCPCCVDEEGRINETWHMAGPEKMDTQSHSQNPPPAEAESRRSGEKDGKAQDELQPASLMASLSNPGERLGEDKREATVVDKEEKVPEYSLSIADEEKRRSRLKLAKDMQYSMENEGVEPGGSFQVGPLCPIAPGRFGTERNEAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBQ9</accession>
    <name>A0A2T4CBQ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1398273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBQ9"/>
    <dbReference type="OrthoDB" id="4986826at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="22796" checksum="E8DC0BFC0A08F57F" modified="2018-07-18" version="1">MDSLPFELITQILTHLPPHDLPSARLTCHAFNAALAKQTFSTLASFVDPAVAQQTIEQLAADLSRRPKAIWSPGCSVPRGLPVPDSFLSAMRLALKGPAATPSPSYSQSSPSSSSMARSPSISSSSSSSSLSAAWSDGEESDAGSDITTYSIEGENITAENFGKSIGMDEVTEDVLRQALFRYALYLSYIYTGEGEAPQLWVMNSKKWAQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBV9</accession>
    <name>A0A2T4CBV9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1398332</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBV9"/>
    <dbReference type="STRING" id="983965.A0A2T4CBV9"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB79061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="308" mass="35608" checksum="2E7814B5E24A2546" modified="2018-07-18" version="1">MAPTAIADLGESYTAGQQLEDVSDAIDDVNCIKYDSESKFDASKDKANFRQYEDACDRVKNFYKEQHEKQTVAYNLAARNRFHSASRVRPEMTVWEAIEKLNTLVDESDPDTSLSQIEHLLQSAEAIRRDGKPRWMQVTGLIHDLGKLMLFFDDLGIQGQWDVVGDTFPVGCAFDKRIILSDTFVGNPDTRDPVYSTKYGIYSPGCGLDNMMLSWGHDEYLYHVVRDQSTLPDEALAMIRYHSFYPWHREGAYREFMCEKDWAMMKAVQAFNPYDLYSKSDDVPSVEELKPYYLELIDEFFPQKVVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBY5</accession>
    <name>A0A2T4CBY5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-related GTPase, Rho2 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1452575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBY5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBY5"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="20872" checksum="7AB2DD486934C098" modified="2018-07-18" version="1" fragment="single">RKLVIIGDGACGKTSLLSVFTLGYFPTHYIPTVFENYVTDCRVDGKSVQLALWDTAGQEDYERLRPLAYSKAHVILIGFSVDTPDSLDNVKHKWIEEATRLCEGVPIILVGLKKDLRDDPVAIEEMRKKSLRFVTTHDGEAVAREIGAKRYLECSSLSGEGVDDVFEAATRAALLTFEKGESTGCCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBZ8</accession>
    <name>A0A2T4CBZ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_228528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBZ8"/>
    <dbReference type="STRING" id="983965.A0A2T4CBZ8"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="56720" checksum="ECEF02DB0EECA33B" modified="2018-07-18" version="1">MVGNREEYWVPEDYEGMTAGRYLATRFSSLKPPMLNVPNPIKLLRMLNRQQWSFFAIAFWAWTWDAFDFFTVSLTVSDLAKQFGKTNTDITWGITLVLMFRSVGSIAFGVAADRYGRKWPFIVNNLLFIALELGTGFCNTYKQFLACRALFGVAMGGLYGNAAATALEDCPEEARGIISGILQQGYAFGYLLAAAFARGLVNTTPHGWRPLFWFGACPPVLFIAFRLMMPETQTYRERERMRIEAGRSRSSDESVGKVFITEGKVALKRHWLLLTYLVLLMAGFNFMSHGSQDLYPTMLTNQLRFGPDKVTVTQVVANLGAMTGGTVVGFLSQSLGRRFSIVCCCIVGGALLYPYTFVHDTSVMAAAFFQQFCVQGAWGVIPIHLMELSPGAFRTFVVGTAYQLGNLVSSASSTIEARLGERFPLPPSASGVARYDYGKVICIFMGCVYAYVILLTVLGPEQLRKSFDVAYDHDAAEVAGWDDKPKTVHDEDYDAKARDSTAEKRTVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC13</accession>
    <name>A0A2T4CC13_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF218-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1419501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC13"/>
    <dbReference type="STRING" id="983965.A0A2T4CC13"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="38"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="219" mass="24879" checksum="6D7EFE0B6C02C15C" modified="2018-07-18" version="1">MTQTDQIHRDATLVYNYHKMNLPLRPASAIFCLCSLDTRVAAHAAQLYLDGLAPWLIFSGDSGILTKGLFSEPEAVVFANIAREMGVPEDKIIVEPRARNTGENVRFTYDLLRERGMLGQMESLVLVQKPYMERRTYATFRKQWPERGTLFTVTSPGLSFDEYPDASNPRELVTSIMVGDLIRIREYPARGFQIEQEIPDEVWEAGQRLVAAGFDKHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCG4</accession>
    <name>A0A2T4CCG4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1371037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCG4"/>
    <dbReference type="STRING" id="983965.A0A2T4CCG4"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="607"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1102"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1228" mass="134967" checksum="2148B96EDC9CC006" modified="2018-07-18" version="1">MAANPVKAARLVSESARERETFEYSSSLLRTVRLNETGKPTPSCELAAADDVILTGLAQLGALQTGTDRALISLFDAQRQCIVAEATPTQRLYPALRSDDCDRPLWLCGTAIPRSHGFCELTLLGDKALAAPGGETSNQLPLTIAYDLAHDPRFSSKPFCQLGPSARFYAAVPIRTRRGINIGVYCVIDETPNKAWTDGDSQRLRDISWAIMDHLEAQRLKGVHKRDVRMNRGLGSFIEGKPTIFGWQKTSDDTDPTDNEAPPNDELSHRQQFLRRQQEEALEDDLVANLSPTTRIADPLGATLLTNAGTPTPIPIPDNDAFLGREQRTLSAASSETTPPAFKPMAALTEDESSIVILSKAANIVRESIEVEACLFFEAPIQPYLSPAQSSSTTDEGSDSSTLSSSDEDEDEHVRRPRKPSPQCRILGYSTSKSSSINGTAPSLSWVNLTDKFLSKLLRRYPRGQIFNFGADGELQPDAAEDEQPCQSFDTLAHGSSLPSRGSEVNLSSLLSPRGKPRTRASTRRLEGKALAKAFPGSRSVCFVPIWDPRKDRWYAGGFICTKDVARNFSLEQELSYLRALGMLAMSEILRYKDLRADKAKTDALGSLSHELRSPLHGILLNAELLIDTKLDIFQGNVAHTIETCSRTLLDTVDHLLEYSRINHLSGRDDRALSLASNGPDLGQFGKKSLLRDSQLDYIVEEVVESVFAGFNFLHLSVKQLSDHQRGSINSDVNANHHSDSLQAMDQLEPWMTKNGELRWSFDDVLIILSMDARCNWAYCVDVGAIRRIVMNIFGNALKHTKRGTITVSLTQEMARLRGRKKERVVRFTVQDTGKGIGADFLKHGLFRPFCQEDPLSPGAGLGLSLVQQITSHLQGDVSIRSELGVGTVACVTLPLEQLPLSSGVAPTISDEEEKAFKEQVEDLKGLRVRIPMANPGWRKAVVNICREWLHMEVIPDTPDTAVTPDLVLWSHMDLARLSEDFETFDKTPNVVVCSNALVAYRQSHVFKKAGSPAIFEFISQPTGPRKLARTLHSAYTRWMSSSNSPTASSSVPMVAKRPKGPKRTPSTFSTPASPGPKTEPPSRILGESLALRDKPEAPQLKFLLVDDNYINLKVLSTYFRKRNVAFNEAKNGQEAVDCFLSHPGAYACVLMDISMPVMDGFEATRQIRVHEAQMGLTPVPIIALSGLATEDAQQEAFGSGMDVFLTKPVKLGALGSLLESHGILNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCP2</accession>
    <name>A0A2T4CCP2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_2106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCP2"/>
    <dbReference type="OrthoDB" id="3513679at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="35809" checksum="C4D852C0C16838BE" modified="2018-07-18" version="1">MEELSYHQRALVRDFNRPFNDITREEKLWYLRTGLEAEHRSCQFWMCAWRTFDPPLDEPLPRIPAYQFQDICNKTVPFHILRGHWRLAGILNNYIYRQWFKPYRSEIEYGQIHERRLGYNGEIATGTAGHNVVVDHQHYVLQPLFQALLLVLNPTDWNGEDSSSIEKIPVILIRTGVEDGLREPITFEPIADKIDAYIGENTIRTTVEAAIGFVMDLETREARAFGLRPDPIASWDPDAAFHEWREIMPYDQLVGPGSWFVDDERYPEWSGAGHRMDTVESVENEQRELRHYAYSQGRETTLIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD15</accession>
    <name>A0A2T4CD15_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1398714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD15"/>
    <dbReference type="STRING" id="983965.A0A2T4CD15"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="404"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="567" mass="64507" checksum="67DBDD6E6F759D59" modified="2018-07-18" version="1">MRRTTATRQYGKPSKKSTAERMFAELVQSPVREPRAKQHEDEKAVEDPVTPLTRRISEITIYDTPRGPIKPRRTSEKDALFLVDEAEVPDVSELKVDSPLSRRTSAIKEKVPKKKSFILEDNITIQQEVKLKETKVKPRNTRSRLSPDKRTSPTAHESLRVLTWSDVCPPGDQIVKIAEASSAEVYRITNKRGTSIIKAIRLPSPIKALTKTQVASGLIDEEPHSESDVNNELQISEWLSDIPGFAVYKERYIVQGKTTPELLETHQTVQKKMKREDPGRAQYYPSPSRYLDDTKFLVVELGDAGKSLENWELDSADQLWDIFLLETIALARAEEVAMFEHRDLHEGNLCIKQARPPRKRPPTADGFFGYSGLEITILDYGLSRAEDLSNDDAAPIVYDLERDLSLFTSTYNPQCKVYRQMRSFLLRADREWLPPEAHHVPYAKGIDGPLSWDVYAPYTNVLWLAYTYQYLVENFRGTKRELAKFTKETAELWKYLDPDAPKDVPSFGCAADVACFALEAGWIRQDELLEASTSVLDHEESIIVAQQDAEASPRRTRRRRGSASGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDH5</accession>
    <name>A0A2T4CDH5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1419972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CDH5"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="903"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1722"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2445"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2592"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2448"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2609"/>
            <end position="2625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2639" mass="296671" checksum="66A495701785E455" modified="2018-07-18" version="1">MPARSSGRIEKARKSKNSTPHQKNHRWESFSTKIAKFNSLQPLRKVRRHDLDTEDLASTTSYLQNGLQKWSELNISKPFSSFKREVLPLCDSLPQILHFEERIMASFAKYISEQDKEGLEPLLDLLTAFAHDLGIRFEKYFSQSLELILAIAGRPQPVEVIEWTFGALAFLFKYLSKLLVPDLRPTYAVMAPLLGKSKHPPFIARFGAEAMSFLVRKAAAPSLRETALVSFVEYVRDDISKMAEDRQFMLYKDGIMTMFAEAIKGTDRTIHSAGSAIFIELVNAIPKEECTLAEITTWTDLVCGVLTSVIHHTGADTFKEFAEAIFDRCDAELKKPHDEDSEWWMVPYVRILGVLAGVRKGNRNSDWPRLVRLLVELLSTATRPIDEATGKNDLLWTSVVVNVAIACHHAPMDSLIPQITRLLQCLTREPYMRFFIPFCSYFSELDPGRFGSLFRSDFQKFIATHWSQGQNEDMLCVLLPKIIENRGFPPAGEKDCCRLPQAWQDQIVSKFESLEISPFPERGPYDKDPQTWRDRCLPKYAALLRILELTSVHPSTNARIAELLLRKLKLALRPSSSLASDEVNFIVSQGFHAYLGMSKTAGSTDPKLAPLLRAAVPRFARSVGFLRTYLAYEQTFPDGHEVEKNDGSGSDTPNAEDDPVIQSLVDNLASPSHDIRLASLELLRKMTSAPKQSQCVEIMLEIEQSPLNLDHTRSIAMYLRKLGQEYGSLTDSTWLKQGIPNFMFGMLTVNLSPVWDDSIEAMKQVAESKSGEDAIAATAFRWLEVPSPRWTPPQSDGGSSRSFYSDFECTTLNYLQAAAKSVQEASDGSDDLMLQKFDDSQRLVEPFSTNAKAQALKVFKALPSIAERRSRQLVPHLFAWAREEDAAIDAQGEDDAQSQAAFWSLADRKGLVAVFAQFINPRVLYQHEQVYEVMLQLLANGDLDVQKLALKAILAWKQDGVKTYQENLEYLLDEARFKNEITVFLQGDTAIKPEHRAELMPVLLHLLYGRAISRKGGVGGRHGQQTTRLAIIRNLSVEDLGGFLEIAVGKLKDVRVVGPMVNRKKLFDQEIISVRKQFGFLNMAQSLISELGTNVTPYMDLLVNTILYCLVFSCRRLSGTSTEADPDVPEEEEKASAHSLLRSTRTTGLKCLIALFQNAQDFQWEAYEDIILEEVVAPRHENLPAETAQGVSGMLQLLSTWSNLPKAALFLSPHGDVLPDGVLPKVIACIAFEKSKESVKIYVLDMLRSLARLAMAPASESEFNEVIRAELLDPNATAILDSITTVLRTGDISNALLEAGIETILALAPIFQALENVQAVIRISSFLLQQPARRVNPRLKGRILLVIENFASLPDAAKDGALLQEVYRTVSALFSYFRDRENRASLCRVLLAISKQDSEIETVASLCNELNQFKEGRIDEPDYDRRLAAFSAISSIHGIPWTPKQWLPVLHNLIFFIRNDEEFGVLSSNAADGIRRLIQEVADCQSPETKAVFDDHLKQILMPSIYGGAREESETVRREYLRVLGFLLTTMPEWPPVADLTGLLNERQEESSEPSFFFDILSPATAKQMDALRTLEAANASKEMGSQNLTQFFIPLLEHFIFGRADGGDDHGLGAQAASTISNLAMSLNWNHFRTTFHRYIGYIESRPEQQKHTIRLLGKFTDALLLSLPESRDAETVEVDQEESSSSVVRRLRLMAPKAAELSTQINDYFLPPLTKHLHQKDESEVSYRVPVGITIIKLLKLLPGPQMDQKLAGVLTDICHILRSKSWEAREMTRDTLVKIAVLLGPTFFGFILKELRGALTKGYQLHVLSYTVHSILVHTVPHFAPGDLDHSLSAVVNVIMDDIFGVVGQEKDAEGYVSQMKEIKSSKSQDSMELIAKNASVSRLIELVRPLQAMLMQKVDLKIVRKIDALLSRITAGLLQNPAAESRDTLVFCYEVIQEVYNARNPEAEPKLDWKTRRYLVQRGAKKSGDRGQTSKHTYKLTRFAFEMLRSMLKKYDSLRTPENIAGFIPIIGDAILEGEDEVKISAFRLLAVIVKVPLGTNDGINVYKIAVKEATRCISMSTSTTTELAQAALKMLAVVLRDRKDIEIKDAAIDMLLGKLKDDFTEPLYRHITFNFLRSVLDRRIETATVYDTLDQVGTVMITNDDKDTRDLARGAFFQFIRDYPQMRSRWTKQLNFVVANLKYDREGGRLSVMEVIHLLLMKSADDFIQEIAATCFLPLFLVLANDDSEKCRLAAEALIKEIFRKSDKERMSAFLNLLRSWLGKDGNAAVVKLAVQLFGYYFECNQDAAKNMTDFKLIFDKVMGILGSDNVRDVDGGLVGASIGVVRTFTTVFPDRTLSANREELWAKLPRCLGHKETSVKLAAVQVISLYLADFAKAGASTSAGEDVEGSYGLTLRPSNVEELVRLALSALNGHEVDESLANELGQVLIFLGPRLPVGESPDASDAESETQELEAEDKEEASSKPKDLQYLFWRLSHILRKEIRPSAVAIAPKVVAMEVLETVCRRSALDRLRPSLRTILTPLHNLTDPSIPAPFSMDEVFKAKHEGIKTRAQIMMDSLQKKFGTAEYSKQLMAIREEVKARRLQRSSKRKIEAVAQPEKYSKDKRKKFEKNKERKKTRSKEQKSMRQAYKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDP3</accession>
    <name>A0A2T4CDP3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1327475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDP3"/>
    <dbReference type="STRING" id="983965.A0A2T4CDP3"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="20709" checksum="0FCC780CB651718D" modified="2018-07-18" version="1">MALNSLWARLRGSAAGGGTPSLTRATALNLIGFATWIPVIAWFNLHVAELTVVDGNSMYPFMNADRDSSLRRDVVLNYKWAPQEDLQRGMVVTLRSPFHPEVVAVKRVVALEGDVIKTKKPYPVSTVRIPQGHVWVEGDGPPGSSLDSNTYGPVSKRLLTGRVTHIVYPLGKFGPVKWWEHDRPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDR6</accession>
    <name>A0A2T4CDR6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1428967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDR6"/>
    <dbReference type="STRING" id="983965.A0A2T4CDR6"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="534" mass="58146" checksum="7734BC12E393FD17" modified="2018-07-18" version="1">MIEEAPPAASDASPPRDSKAHDVEPVVEESADNRVLTRLGYKPVLHRTFNLFHNFSTTFAALYFIGGVRVTFSTGIAAGGNLAYWTSFIVTCVFSFISAAVIAEICSSLPLAGSIYLWAAEAGGPRWGRLFGYVVAWWSTTAWTTFCASNTQGAVNYMLSEIVVFNIDFPSDPSSVKFRAVQWICTEVLLALAAIWNLLSPKYFKWIFYLSTGFVLLDFVLNMIWLPIGTAHTLGFRTAHEAFMTTYNGTGASPGWNWCLSYLATAGILIGYDASGHVAEETRNASVSAARGIFWSTVVSGLGGFVVVILFLFCTPDPDTLFSYGSVQPFVPLYAVLLGKGGHIVMNVICIVALWFNTAIAILAASRLVFAVARDGVLPWSSWVSRVSDGQPRNAVIVVWAVASLITCTILPSSVAFTSLVSAAGVPSAAAYGLICLGRLFFTPKTFPKPAWSLGRWSKPFQAVSVLWNGWVVAVLFSPYVFPVTGETLNYAPVIMGAVTIFAVVSWWVIPEERWLPSRRIKEQLMAGESADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDS9</accession>
    <name>A0A2T4CDS9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_245179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDS9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="18215" checksum="C375286963590854" modified="2018-07-18" version="1">MGSVPGQGSSRHRHHYISAICRKPCLTRSWTTLSTTSVFSIRWYNTPHPWPIVTAICWCCVCSANKPFSPSRDNKGQDIKGQSSSPPVLVLIPTEHRTSQILLVPSGGFCSRDTAPFCRFISACVCPDGIFPVPLYIPLFVFVDHIALPTLPILSSAPRFIWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDZ4</accession>
    <name>A0A2T4CDZ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1327268</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDZ4"/>
    <dbReference type="STRING" id="983965.A0A2T4CDZ4"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="370"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB79765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="60605" checksum="7EA35943C6D6BF52" modified="2018-07-18" version="1">MDRPPETTPGGTSPRTFALNHARPKSSFQGCSRISDYELQGKLGEGTFGEVHRARSRKTGALVALKKIIMHHEKDGFPITALREIKLLKLLSHPNILRLEDMAVEHPTRQTDKRKKPIMYMVTPYMDHDLSGLLDNPSVHFKEAQIKCYMIQLLQGLRYLHENHVLHRDMKAANLLINNKGILQIADFGLARHYDGPTPRAGHPVGEGRRDYTGLVVTRWYRPPELLLQLRQYTTAIDVWGVGCVFGEMLFGKPILAGESDAHQLELIWDLMGSPTDENMPGWKNLPGGDHLSPRPRPGNLQSRFREYGTGAISLLKDLLKLDWKTRINAVDALQHPYFKKEPLPLEPHQLPTYEESHELDRRKFHDRKAALPPAPKGGTVGLGPDANGATAGFNSSDAYGSGRNGVNGGRFRGPDDRRPAWRERGPPSRPPQDRPPNWDDADHRDRDRPPRSRGPGRGPDIDTYIPSYGREEAGSRRRDDDRPRDDRRRPTSKDSGRRYDRDRRTRSRSRSPIQDRNRDRDRTDRDIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE04</accession>
    <name>A0A2T4CE04_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1325824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE04"/>
    <dbReference type="STRING" id="983965.A0A2T4CE04"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="73"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="287"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="465" mass="52101" checksum="460F37D9E485C1E4" modified="2018-07-18" version="1">MFSVALRCRGRRCRPSDWSTLAPCGLSNAIPRATFTAPSPLVRTQLRTAAQAGNGTWRPVSVLDEWVAKEARPISLRQLMVFGRSLTESRLISSANYVRTELPVRIAHRIRDMQKLPYVVVTNRHIEEVYKLYYNAFDTFRKVKEIRTLEDNEKFCEIISQNLKGHLTVIPKLAMGILECGGLMDPKELDHFMNVILRSRISRRVIAEQHLSLTETFNSPYFSPGATLSESDFIGEVFIKCSAKDVISRCAKAVTQLARTTNGPDVQVPEVRIDGHLNASFPYILSHLEYIVGELLRNSVQAVIDRHQKQGDHASSPPPPIEVTICEAQEHVIIRISDRGGGIPRDELPYLWSFSKGPLSQKRLENLGQVPRMAATMQELHVTDELGRADLKAPTYLGSLSTLTSRPPNLRLGMGLPLSRVYAEYWAGSLNLHSLEGYGVDAFLQISRLGNKNEQLTTRASMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEG3</accession>
    <name>A0A2T4CEG3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEG3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16513" checksum="EA643D264F9FED9B" modified="2018-07-18" version="1">MYDDHAMDELVPVQAPPSPHSHLVLWLASGWVKGGFGLAGGESDARGTWTSSGEQSPEMLVSLGEGRRREEKQKQKQKQKQKQKQKKRENVMCLRYCRCESAREGKDAVPYRVAGGPLPYLQFVLVLDPQGMLSVYKDRLEKRAAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF84</accession>
    <name>A0A2T4CF84_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1388548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF84"/>
    <dbReference type="STRING" id="983965.A0A2T4CF84"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015617220" evidence="2">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="119" mass="13136" checksum="CFC2F0564C06A074" modified="2018-07-18" version="1">MRAANDPRANTWRLISAGFLLVSLSRIVGHAAATTGPQVHDATFIPDHVLRVTSEEIGIGGIRRYSTLINGTLPGPEIHIPEDKVVWIRVYNDMEDGNLTMVRMAHLPNPISAAWRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFP9</accession>
    <name>A0A2T4CFP9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_16587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFP9"/>
    <dbReference type="STRING" id="983965.A0A2T4CFP9"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000096">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="952" mass="103410" checksum="DE7B0F0DDEEE3D10" modified="2018-07-18" version="1">MAPQRDYYADLGLTPSADIVEIKKQFRKLALKYHPDRNPGREQEVNSQFQIIQAAHEILSDPEAKAKYDATLLRSASSRYPSASGVRGNPWSNVSQQFPVPPRRTAPRTTTSGPQRWNERFSAGVPPTAKQQASAATAARAFESMRKGGAKGRPQDRAPPPPPPRNPPTPPPRTEAAKKRAEASFGAKKAGYYPRSNTPGDEPPVTNNNYSSRTNSTRTAPAPKPDPVADPLAQFRQWNGNEEAARSSAKSSSNMSSGGEKTNPSDSIPSGRARSTKETPESAGPSTAPKRRSPDVARRETADGFQRKPDGPGVDGRPRVVPVPPSSRPGAAWSKPQTDPETSTTATATPNGNVFATNQTTNPPATNEPTTRATADLFTSAFNNRASPAKETGEPSMYATPVRSNSYSAASCLKPQSANSPQTTTPKHNNVAEVGSNHKRRDPSGSSHAVHSLSPFEKEQYRMLKLLIKNRDAPVLRPRNASHHSIPSHVKPAIEKPSANSVLPSSFSFNLDEEAFTPSPPRTSKFRKSTSADGINTTFVEDESSATWQFSAGSGDNNPPPLNRSQSDSRAGRRSPIKRRPVPSPKVPDLGAQAPQNGFDADSWNSMFGPQTFAPPPATPKASVSPTRQGRSSTRKTTRTTRPLAGNAAIVEEYSEEEERYVWTGRKNDPKPAPVDSPQAMDIDPPLTASPAAIHTPSPPPPGAAASTATSTTAFSATPPATQPQSQSHGPAMAARNIPVEPSRPEWRPGNVTGLAQVYEPAEERKPMTANLQGSEDSEEFRATFEDLKNVAPFATPKAGLKSFTDLKDSLPFESQASSELHLDVPQAQPLVFPEPPVAPRLPPTVAVDGVKPNVASWNKYVEEFEGYLRLWDMFNSQVVDHFATRKSNILHTRASKGYSFLGARGDTDIVEYHNWVEQDNGVRRRWLAACEEHEMRFREFMAFREKMKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG28</accession>
    <name>A0A2T4CG28_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1388781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG28"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42699" checksum="6F74CFF1906ED16E" modified="2018-07-18" version="1">MPALSYFNVITWFAPKSVVLANLFGVSSGLGLFPMTFDWAQITYVGSPLLVPFWAAMNVVGGLAIIMWIIAPLFYYSNVLYSSYMPILSTAVFDNTGKVYDVSKILTPDFLFDREAYSNYSRVFLPVTYMLSYGVQFAGLAALLTHTVCWHGQDIWHTWKESLVEARGQGKEGYEQVSDSPDGPSSPQGAAAAAAAAPRASSSGSHIEGLMSHEDIHSRLMKRYKDAPLSWYFLTFISMAVIGIFVVEYYPVHLPWYGLLLALAIGAIFFIPNGIIMAITNQHSSIYLICQLICGVAFPGRPIANMVFRRANAWWGKYTMTLSAALDSGLAFGIVVVFFGFIYPGWMRGFSWWGTEVYKRGCDWQACSFRNVKEGERFGPDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG74</accession>
    <name>A0A2T4CG74_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma interferon inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1324614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG74"/>
    <dbReference type="STRING" id="983965.A0A2T4CG74"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26662" checksum="C53AEE37547E8EEE" modified="2018-07-18" version="1">MSSSPRRIRARDLLFIVTLVVLIYQLWNNATAVPFLPQEASDLVAPTRDETGSNGLVPLEAHIISKCPDTRDALRTLILPVMQQVHDKVDFKLSYIGKPTANGGVDCKHGPSECIGNIIELCARELYPDPKINLGFIMCLTKDYTHIPERTLIEDCALEHAIDFNKLNECAARDDTAHGLELLRNSVQRSADANVTVSCTIRLNNEIYCIRDDGEWKDCPHGPGVNDLVLAIQKLYHGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGA6</accession>
    <name>A0A2T4CGA6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGA6"/>
    <dbReference type="STRING" id="983965.A0A2T4CGA6"/>
    <dbReference type="OrthoDB" id="4574581at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="76284" checksum="00C5C55564DE85FA" modified="2018-07-18" version="1">MADAFEGEDLLYNLAYECEALFDSLQDLLRKTESSDALVRLCSEFQQRFAIWAAHLGVFARKSQCLDTRLRNIPDLQDLVARLLDILRRSLQQCTAEPPCQRENDEVMTDIHELPSGALRIQTADLKTIDDTLTRLNRVGVTVRQSGRGKLDTRAKRFAAGLNLSSFAHLCANAVQALYPSAHQSLKDHLTRSMTDRYARMLFLDSRHQNLQARRNLHAGLPPIHEVPSDEMTPSGPSIPPRTAIKNSAIQKLFRQPSALSQSDLSSVNLQQIRSRLRPPDEASTKFHKTSSIQVNQGNYPRIPATTDDSTVITCQWCSEPLTKKTLSESEWRRHIDRDLKPYICLSEACPDAHPAYATFDEWYKHMKLHDWRWHQRTYLTSSWVCTICESGSGTYTSPQALYLHLEDMHGRDFTQAQLQAISRQSKTEQPRASRDCLLCCFAVEEQGDFGQAVFAKRRKRQTKQRASKSVRKTLEMAHPSPHNSGSELSDTSSASDGMGSGHRKQRGEGRSLAVSRHVAVHLQGLMLLTLRFAEALQDNDGDAGDDARSNSVDIDEGNSASGGTDLGRLSHIASDEDVAPKNESDERNTESDMDSVQGLGDDITADDMPVPDTDIDLQYIPRQHDNLAVEDDEFLNELIESGDFLYGETSTSSTESASSFPMMGMGMEMVMRFQTKLDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGJ9</accession>
    <name>A0A2T4CGJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1436209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CGJ9"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="287" mass="32407" checksum="8FA1A43954F1F5EB" modified="2018-07-18" version="1">MGKKRSREEAKDTPPADAGADRMDEDSSDDEDFDMVNVEFEWFNFDPEIDFHGTKSLLRQLFDVDANLFNMSALSDLVLSQPTIGSTVKVDGKANDAYAMLTVLNTHEHRDKEPMKDILKYLVDKAQTNPSISAVAELLGAQKPVGLVLSERLINMPSEIAPPLYTMLVEEVEDALEDKEPYDFSHYLILSRTYQEVESTLDVEDRKRKKAKEEASTYHFHPEDEVLEKYAVAHGSFRYTKEDDAVADSKRAFQEMGIKTFGHMILIEAGKFKEAVKAVGDYIAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHV7</accession>
    <name>A0A2T4CHV7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1417872</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHV7"/>
    <dbReference type="STRING" id="983965.A0A2T4CHV7"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="14">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="453"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB81161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="489" mass="55610" checksum="99C5E46D5BAA239B" modified="2018-07-18" version="1">MAGLPDLEEWYADANEALNISLVSPSKSGLKTIATFHPKFTYSIFGDDEKIFGYKDLKINLRYRANDMRPHLRVAYSKKMKPVGEHEPTDVVEILEQGGHLPKVAFVKGSDFENSSQQLGDNWTPPGTLYQSFDGSDGQYEVRTASLVDPAIKQLNSRIQIFARLFIDGGSYIGEDREAGPSATPDLSDADKWTFFLLYRKQKSVEDPEKSAYTFVGYATVYRFFYFPAIPTPPTSPTENWELPAGDMDLSELPCRTRLSQFIILPPFQGKGNGAHLYNAIFKFYHDHPQTQEFVVENPNEAFDDLRDTCDLTFLRSMPEFKELRLDTKVTVPKSGPLPPLIVGQDKLEQIRLKAKIAPRQFYRVLEMHLMSQLPRSVRPTMSLDDDVPTPTAADKHQEKLWQLIVKQRLYRHNKEVLSQIDVGERIEKLSETLGSVELEYARILAAHERAMKHTVPSNGKRKADDGLDKDMEEATSSKKARVEDAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIH4</accession>
    <name>A0A2T4CIH4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1418062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIH4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="17318" checksum="74645798DCED4492" modified="2018-07-18" version="1">MTTQCALQAALGKQSRLVLHGFLKAAPDIVIITGGVTDNDFNQARHELELEVAKPQSAGQAYIANETNLAVRDLARLLQHEGKLFLPTRFAADCRRNEDVWPLVLRWRLLESVITVSKADWDQLISGAAPKLQGLEGRRIFRAWQGRRGMSEVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIL2</accession>
    <name>A0A2T4CIL2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIL2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="13059" checksum="11C3D0B6AD2549FE" modified="2018-07-18" version="1">MVVWSPRKPAPRVRKAWGLAIHGVVGLGSRGEHAMEVGFQTLSWANGVKVLLLPPADRCYYYPQVNDEWAFQIADRCQMLLARASWEDWSERREIVESFRHLHETDFRPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJV3</accession>
    <name>A0A2T4CJV3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_23902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJV3"/>
    <dbReference type="STRING" id="983965.A0A2T4CJV3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37156" checksum="F202994F86CCD884" modified="2018-07-18" version="1" fragment="single">MHTFPYEAPEVGEKLTEDGAKKTDAYSYGMLIWRCMVDSHDILTSLGMSTSRGNLGDSKLRDNVKLLKLSDGLLEAAIHNVANYFFQHQLPGQSLNLVTSALMFTLRGDPNQRALDRAQVRLRGMDSVAALHYVGIKDEANRKTLESLKHQTPGQHGMDLDSVGFGLGRLGNDYDAQNNLPGFRPDLPRPTRDGFLFKPLTLRHLLDRAQQEAMVRDFESLANSPAPVERDTSGDLRPEPWSAAFFLFQTYLCGFGVPFDAEKACYWLCRAADPPEEQGETDYLALAWMNRVHAALGVPNPYDTEKQIENLFWGTIRGHRHCVEDAEAVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK28</accession>
    <name>A0A2T4CK28_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1323195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK28"/>
    <dbReference type="OrthoDB" id="4900606at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="306" mass="34889" checksum="D3A5A1FE175032D3" modified="2018-07-18" version="1">MPCLHNHHQPPVLHSRAPHDGEISSPAATGLAIGLILVALVVAVLVYFWCWRQQEPRNHHREARHRRENQREPAGQNAAGNGARAAAAPEVQQVAQRRDDAAQGQQECPLPAVPLSIHHHQHDDKHFHGDQYHDHLHEGDHILTCPDNNNRNVQDNFHHRHNHHDHHHRHHHQRHHRFSRSHRTNRLIIPQDPLAEIERFFRPPSPGLPDINRADLEAILNGLDVPLPNGAAQRNANAQEQGDVRRDDEGWKISQRHNINFMPPLAPPQHVLPLLPWDSSAPYCSLTCACVRVSSLRIELSLRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK34</accession>
    <name>A0A2T4CK34_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK34"/>
    <dbReference type="STRING" id="983965.A0A2T4CK34"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="848"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="919"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110568" checksum="271163422E6CE4F2" modified="2018-07-18" version="1">MSAFHRRKGAANGEGDLEAGGREDHSGSTVAPPEQELPEYAALERYISTYREGSRMGDEDDSKKRRPKWWQFWKSSGPDVIDAQPAKRVVPEAWLETDIRTGIRINEVDERRTWAGWNELSSEKENMFAKFLGFFTGPILYVMEVAALLAVGLGDWIDFGVICGILLLNAFVAFYQEKSAADIVASLKGNIAMRCTVVRDGQEQNILAREIVPGDILIVQEGDTVAADVLLICDYTRPEDFEVFKQLRAEGKLGTSDDEPEDEDEKNQESPLANHRATPLVAVDQSAITGESLAVDKYIGDTAYYTTGCKRGKAYAVVTATAKDSFVGKTADLVQGAKDQGHFKAVMNNIGTTLLVLVMFWILIAWIGGFFHHLKIAKPGSQNLLHYALVLLIVGVPVGLPVVTTTTLAVGAAYLAKQKAIVQKLTAIESLAGVDILCSDKTGTLTANKLSIRDPFVCEGQDVNWMMAVAALASSHNLKTLDPIDKVTILTLKRYPKAREILQQGWVTEKFTPFDPVSKRITAECRLGKDKFICAKGAPKAILKLANPPEELASVYREKDREFARRGFRSLGVCYKKNDEEWVLLGLLSMFDPPREDTAQTILEAAQLGVPVKMLTGDAIAIAKETCKMLALGTKVYNSEKLIHGGLAGSVQHDFVERADGFAEVFPEHKYRVVEMLQQRGHLTAMTGDGVNDAPSLKKADCGIAVEGSTEAAQAAADIVFLAPGLSTIVLAIKTSRQIFQRMKAYVQYRIALCLHLEIYLTLSMIIINETIRVDLIVFLALFADLATVAVAYDNAHYEPRPVEWQLPKIWLISVVLGVLLALGTWVLRGTMYLPNGGIIQNFGSVQEILFLEVALTENWLIFVTRGGRTWPSWQLVGAIFGVDVMATLFALFGWLSGAPEIDNPVDLATQRHDGWTDIVTVVIVWLYSFGVTIVIAIVYFILNQIPALNDLGRKDRKKKDTIVENVITALQKLAIEHERDDVKGVDRYLLSDKVIDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPA6</accession>
    <name>A0A2T4BPA6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_69038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPA6"/>
    <dbReference type="STRING" id="983965.A0A2T4BPA6"/>
    <dbReference type="OrthoDB" id="4884061at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="67"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="434" mass="49873" checksum="4ABD44B7087BD860" modified="2018-07-18" version="1">MDDKQQELESPSLRQTQVQKPVNTQKQPNTTPQLNSASEEDVDEGRAAYRPGGFHPVYIGDVFNERWKVLNKIGYGRYSTVWLVRDLQASGDMSKEFRALKVLSAICYGQGRDTFEKEILVHLRDGDKSHAGYPFVCHLLDDFEHQGPNGTHVCLIFELMGETLRSFGSLFHENMIPEPVMRKFTIQLLVALDFAHDHNVIHTDIKPANIFVKFRDYSMIESEYLQEYIPQQDRQETHYRPIKHCPLDSFYYKEEDTTRILEFDVALGDWGVASWADRHLTELIQPVALRSPEVLIGAPWDASTDWWNLGAVVLEIYRAVRMFDGRVAPDGRYEVKEHLAEIVDLFGPFPKSLLKRGNRELVDAIFDDEGRIKDQEPFNRPGLASEAFMPGLSQEQRDDCASFLKLLMKIDPAERPSTVDLLRHRWLAALPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPM1</accession>
    <name>A0A2T4BPM1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1386815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPM1"/>
    <dbReference type="STRING" id="983965.A0A2T4BPM1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="587" mass="62544" checksum="584B613ADB1BCD0E" modified="2018-07-18" version="1">MASGDVDGYGSRVAGLNSKLQRFWALKRLVNKGQPTTDLDIPLAPWRKGAITCALALAGFMIGVDQSIIEPALPTIIAQFSALHDVGVYTSAYLIPQCVLQPCYNRLYSICSFSSVYISSALTFTAGSIVCALSESSPCFICGRALSGVGAVGLSVGGFRMLALMPGDRKQNVSTGAFSLILGSSVVIGPIIGGVITQSHLGWHWLFWINLPVIGVVLLLVVGTAYTGGSDLRGEKYELKSWEKVKLLDWMGTALLALTLIPLILGLDFGRSYGWGSIRSAVMFAVFGLSFVLLLLQQRLAKTPLFERSILLNRSVWTTTGIFFCALSSMSSITLFLPFLLQVVRELNPRSSGLLSFPLAGTLAVSTFIFSVLSTKVSCFNPLAIAGAAIFLASNILFITLNSDFSLPQIVSYEMIGGLGLGMAWLAEIIFPRAVLDKHQLAMSLGYSRMLQQIGAAVAVQVSAVAFTTSLAHNLAGLPLTPDELLSLQAGKKISGDFSAHTKNAILAAYCKAIRVGLSPAVAWAGLALLFALALPWPSLQRHVADSKEKNNSDSGSESLVLSVLGPSREADSPRDQDSPARGVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPS8</accession>
    <name>A0A2T4BPS8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1406697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPS8"/>
    <dbReference type="STRING" id="983965.A0A2T4BPS8"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="DUF7580" evidence="9">
        <location>
            <begin position="179"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="609"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="910" mass="101778" checksum="2C38268810A7BCC2" modified="2018-07-18" version="1">MPQTPDRDIQEVVYEVCLVAGAFRDGLRPASQRTYRIRCLDELSESELQDLGIELHRISLHEGISLPLLTSSADLTRCFSDIAQCMNDMLEELYITRLANRFLSVAANRGAALWKLAQLITWSPREISIESAIRQDIGEICFTLLPLLQIWEQLINQLMPSSKRLPGRQIETSALRNAASIRTSTGKLHRTLHEHWPCRLNVQAHRGSLCDCLMADLQLEPHWLMSGNDEESFFLLLKGSGISQECKIHLSEPSMDSLTNDMEDKQTTCLTRHEDWQDYCLYLSLEKSGQLLAWPSRSFDVQLQWHNNLCDTVEFRLVTLETLLQCLSPKYDARTCVELVLARSLLLLLHGPWVESHLHLQNVSVFCKIENGVVMPELDKLFLSTRFGSAIDPRPLHNSWSPLTLRAIEAFAILLAEIELGDKVMKIYESLEPDLKAKRPTKVAKALLHECEKRLPCGRGVVQVIKSCLNRELFGCSSWQSPDGPIQNDQAFIECYYSNVIAPLEQELVEGLEWSWDEVKGRAPSRLGDTHVADVIKPLEACQSGKAASTPAPTVLAAAGHTTHTDNDPAERETPKGSDSDGWFEELKKAHFKRYRRRKDDFDEESPRHIKVAVIDTGVDLTHEAFEGLQESGQLIIQEGSNIVDPGQPMTDSDGHGTHCCELILRTAPFAQVYPLKVSSARTGVSPQLVAKAICYAIKEGVDIISMSLVFDREEKAVKGALGEVMTKLGERADAPKPVLLFAAASNNRALDLNRIGYPAREWEKVICVNCSTKYDEKSNFSPHGETGAANLSAIGENIKVACPNSRGGSWKRISGTSFSTPIVAGVAAMLLDFAMQDLTGFSDLEEWNDKKAELWELIGMRSVLKRCMTSAYEDGRYNLVKPWELLSKSEGQIAHAILEALASKHRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPV4</accession>
    <name>A0A2T4BPV4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1395795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPV4"/>
    <dbReference type="STRING" id="983965.A0A2T4BPV4"/>
    <dbReference type="OrthoDB" id="4900688at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31704" checksum="F61295BD05E3973F" modified="2018-07-18" version="1">MSFFKSIADLSTQSLTEAQSITFNRWVYYDAPIFQGRGLIDWRLGEGSDLYCEMVEVLQRLATALNSQAKLGATLDAKPMDGSTQTEKHVSEQQLSKSGVLSAWELPSCPKMPPGCSEIYCPYCCRSYPAEEYSGENWPRHVIRDLMPFVCVMDSCPTPNAMFESYEEWTFHMEQHHSQKAWICRRHTLAIHFEEKEAFKSHMISSHGAHHITTYYAIKPLKPTLLPFEPLEHCPLCDEYDSPHGSETVNEHIARHLVSLAQTSLPEDFLRPRKADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQN8</accession>
    <name>A0A2T4BQN8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1386262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQN8"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF3">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="1">
        <location>
            <begin position="242"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="37331" checksum="5E28007208876422" modified="2018-07-18" version="1">MEELISSTALTQLERIGQGRCGTVWAVRCSSACDNHTHLAMKREDGSTGRSISHEYRVYQKVTRAFLQSDFTTFAIPRSVGFLDAEDDAAWSLILPRLPPDYAACNAIISEKILPVEASARRLLVQKFRPDVDAEEIMRSQSNEHCLVRPYLGRRRYHQTLSLRNYRLHMDQMEQLGIDPRGYAVAMADALAFLHWVAHVDGNDVEFVLGQPRCRPDTSSPSTRIQGICSDTNTAILGSHVVWILDFDLCRDMALDKEGVDQANRAFWGNDPYFPRPGSRNLADQTLWTIFQDRYMASSAAALHKEPDCIKRLPGLFIERVKRSRVVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQR0</accession>
    <name>A0A2T4BQR0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1406419</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQR0"/>
    <dbReference type="STRING" id="983965.A0A2T4BQR0"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="32019" checksum="A378B4C5DB80247E" modified="2018-07-18" version="1">MNNALRLVRNAPSRTATSSTPQWACFFCQNARPRTSSSRPNLADLRRKFSSSRPRREQQPTQTQTQQQAQHNATYAPSMDRVREQYSQRNKTIAYYTLSVIMGTLALAYGSVPFYKMICQTTGWGGQPIRAYGQSGENQDISSRLVPVTSANRIKVTFNAAVSDVLPWKFVPQQREVRVLPGETALAFYKATNMGDQDIIGVATYSVTPAQCAPYFSKIQCFCFEEQRLNAGETVDMPVFFYLDPDLLNDFNMKGIETVTLNYTFFKARYDNNGRFMPPATQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR12</accession>
    <name>A0A2T4BR12_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 18 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1386092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR12"/>
    <dbReference type="STRING" id="983965.A0A2T4BR12"/>
    <dbReference type="OrthoDB" id="2589715at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11576">
        <property type="entry name" value="GH99_GH71_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015530192" description="Glycoside hydrolase family 18 protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44253" checksum="7539CCEFA8B65417" modified="2018-07-18" version="1">MHASLPSLLLAAAAIATAHSHDNHARAHQEHARAAAVDTSTLKGKWLYGYQGWFRKPAAGVNNHWSPNGGTPGPGNVEFEFVPDVSQYPANCLFASTLTAPNGQPVQLYDNTCEGVVDLHFKWMQQYGLDGVIVQRFLSHLDDASFMTILNQVEAAAVKYGRGFMVEYDASGGNSATASVAAQILADYNGKVKPYTSSSAYLHHNGKPAVMVFGVGFPTVHINVTDGANIATQLKGAGAYVGYGVPANFGTDVRANTGFASAYKAANLISPWTVGSYSEGGYKNGYHTTTQIPDSQTLQSLGIDHAPLIWPGTSAYHLNGVTTPANFDYFPRYNGSFYSMQADAITSLPVKPLFAFNAMFDEINEGTQSLPCLKTNQLPTNEKFVGYDNSFADTSFYLELGGQKAAAFAAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRG8</accession>
    <name>A0A2T4BRG8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1364448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRG8"/>
    <dbReference type="OrthoDB" id="10477253at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="9708" checksum="6559287FFC8ED861" modified="2018-07-18" version="1" fragment="single">MSCTHLDNELKQVQAREQQAYMHLRRQLGLSPIPEQQDTATSLPPPIPPRNPARGTPYISKHIHARNLSFEKDITQKQKQVLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRP2</accession>
    <name>A0A2T4BRP2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1102988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRP2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="18858" checksum="1C943A06FE0FFD6D" modified="2018-07-18" version="1">MPLMPFSGRSLSFGQYLRGSYLQQESCGRNPAPGRCAHRLVKWKGTKSGGLPSICLWRSDAPLFHGHRHGSASCRIPRALHCPVGHCLGKDCHQRGPFPTRSYVAGSRLRTSHVVGRGGCMRFMSRRIRTALEPIGCPSPRLFAAIGIIVCKPFAVHPYKPYGRSNSTWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRV6</accession>
    <name>A0A2T4BRV6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1405800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRV6"/>
    <dbReference type="STRING" id="983965.A0A2T4BRV6"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="70523" checksum="7D5A94068723825F" modified="2018-07-18" version="1">MKLPGRVDGSFCGAVLVTRSTAGVARNNVFPRPHAARDAPETRSRPAQPTASPITNQGFFCPRSSQWLLSTFMPGLETHKHRTAPAQNPRRTARAYGTAAASHALHGPGTRQRLPPPAVVQDKDKMLSYVDQSDVGSAEEYFEFYRDPYRRGYAAPDGPRLQVSENKRDVQFPSKDETAMVREETQPVLDRLQAAIGQRLRHPHRYSLDEIYKLYCQLPEPRMLCLTWQWRNRLLKVMGTPQKRDMDSMLRYFALVADVKNAGLTLRRSQWNFALAFATKYAARASTQEMESALRIWKEMEKEAHMMGNEVTFNILFDVAAKAGNFTLADMIYKEMEKRGIEFNRFHHVSLIHYFGLKLDSGGVRAAYREMVESGEMIDTVVLNCVISGLLRCGEEAAAEETYQRMKNDHDMASEMPQKDYMMNKVVTKVLMMFSRVGKQHPELKKSFQTNVRLAPDLRTYKLLVNHYATRVGNLQKVAQYLDEMKHLKIAIHPTIFLALFKGFYMHGGYPGSDWSEQRLQGVLAGFYQAHDERGADFRIDQWVVIWALRAVKKCSSNEALIQTFESMSQRWVISPERQQFMHALFQNILHDKDLKSTRNDGLEQMRSKDAQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS30</accession>
    <name>A0A2T4BS30_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1425949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS30"/>
    <dbReference type="OrthoDB" id="4881893at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015619775" evidence="2">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="127" mass="13738" checksum="1A0E49AD916A16D8" modified="2018-07-18" version="1">MLGWACDVVVVELATLGQAAAKDSSCSRHGGRFEARVGNTPSQVSDKKILSIAITPSDFPNTQDNTRDANMVRLYGDAVIELTASRIQPNDFYKQCLSHFGPVEQRAHHGPNDSPLNDSIGPLMWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS66</accession>
    <name>A0A2T4BS66_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1405900</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="5"/>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS66"/>
    <dbReference type="STRING" id="983965.A0A2T4BS66"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB72152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="380" mass="40406" checksum="4A82C493476B320F" modified="2018-07-18" version="1">MAQTFRILILPGDHVGPEVMAEALKVLDMVEQCRPNLKFERTFDLVGGSSIDKHGVPITEDVLDKASKADAVLFGSVGGPEWADASPNPEAGILGLRQRLDAFANLRPCEILVPSLLDASPLKPEIVKGTKFIVVRENCGGAYFGDKVEKPEVASDLWVYKPDEVERCARVSAAVARILGRNGDGKGGDGPAIVWSADKANVLASGRLWRRVTQDTFAREFPDIELRHQLADSMAMLMVKNPRGFNGVIHTDNTFGDILSDISGGIVGSLGTLPSASISGIPGQGRCNGIYEPVHGSAPDIAGKGIVNPVAQILSLAMLLRYSCVLVDEAAAIEKAVETVFDSKDVGGLGIRTRDMGGEAGTKEVGDAIAVELRRLLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSQ8</accession>
    <name>A0A2T4BSQ8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF590-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1425824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSQ8"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF77">
        <property type="entry name" value="MEMBRANE STRESS RESPONSE PROTEIN (IST2), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="188"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="83004" checksum="2883C62CD098AB73" modified="2018-07-18" version="1">MPLHLEVPPLGDPDLRRSPSPPPSPSRALQTYNDKYVVVYDFSEIDYYEATKEFTALIHSLEATGLHVEVRPGYEQTILLFVKAPSALLGNRVYKLRVRDWLYGITQTRPPGNKHTIVAAWYEAEDLLSMAHLVSWPQSMGGAGITPGLGEWKNVKAIFPMHNEKENQRLLRSFSKKLLLGTDDLDQIRDLFGSKVAFYFAFGQSYSAFLLFPAVTGLVSWLWLPKYSIVYTILTVIWCTVFLEYWKVREVDLSVRWRVRGVSKTKTNRPEYKYERVIVDQYGRTIHYTPKWKQISRQLLQVPFMAIATVALGLMISAVFAVETLISDSYDGPSNLYLDYLPTVLLAVIIPYISSYLETVAKWLTDFENHRTADSHEMSLTQKIFILSIITNYLPILLTAFVYVPFGDRIFPWLEDHIVRFAPTIGNRLTEKPFRLDSDRLRHEVIALTVTGQLASFFEENILPLIKYKMSSWYREYRRNYTKDTILISMVTDDEDEAQFLEQRRNEATLEPYNVQDDIAELVLQFGYLALFSSAWPLIPLGFLINNWVELRSDFAKICIEHQRPAPTRAEGIGPWIVSLEILVWLGSISSAAIVHLFSTDGVLSGGWSTLPLTIFVSEHILLALTWITRVIFQRLGSEQLRRERSEQYARRLRILEEIEEHKRDGEHIGSRERERRKSLLIAGNESFWTKQLEEGASTAAGMKLISLARQSDVREGKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSS8</accession>
    <name>A0A2T4BSS8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1384992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSS8"/>
    <dbReference type="OrthoDB" id="5988651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="6705" checksum="644B061551FB58D4" modified="2018-07-18" version="1">MTKNEMTKSAASNIQSTQAKGGKDMSSSGFSARAQSAADRNQNDSQGTNSGGGYGGNSGNQSQTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTA8</accession>
    <name>A0A2T4BTA8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1091862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTA8"/>
    <dbReference type="STRING" id="983965.A0A2T4BTA8"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
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        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
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        <property type="entry name" value="GAE_dom"/>
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    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="725"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="664"/>
            <end position="730"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB72547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="836" mass="91729" checksum="4F767741CF81E806" modified="2018-07-18" version="1">MSSLKQFIRNVRAAKTIADERAVIQKESAAIRASFREEGHDHSIRRNNVAKLLYLFTLGERTHFGQVECLKLLASPRFADKRLGHLATSLLLDEKQEVLTLVTNSLKNDLSHSNQYVVGLALCTLGNIASDEMSRDLFPEIENLISTANPYIRRKAALCAMRICRKVPDLQEHFVEKATALLSDRNHGVLLCGLTLVTSLCEADEEEGGEEGMVEKFRAFVPGLVKTLKGLSTSGYAPEHDVTGITDPFLQVKLLRLLRVLAVGDAHTSEQINDILAQVATNTDSSKNVGNSILYEAVLTILDIEADSGLRVLGVNILGKFLTNRDNNVRYVALNTLIKVVAIEPNAVQRHRNTILECLRDPDISIRRRALDLSFTLINETNVRVLIRELLAFLEVADNEFKPTMTSQIGIAADKYAPNKRWHFDTMLRVLSLAGNYVKEQILSSFVRLIATTPELQTYAVQKLYINLKKDITQESLTQAGAWCIGEYGDALLKGGQYEEEELVQEVKESDVVDLFSLILNSSYGTQVTTEYIITALMKLSTRFSDAAQIEKIRRILQTHQTSLDVEVQQRAVEYGNLFAFDQVRRGVLEKMPPPQIKEESRVLGRAPSKKAKSANRKSKIIKPTEQDLLDIMDTPATVSAPTDGSQATNSDLLADILGGGLSSAPTSASPGPQQSNISSIMDLFGPGAATQSSPASAPPSAGLDIMSPVASPPPQQQQPPPPAAQGQTIPCYNANDLNVTFTVQRNAEGLIQAVARFQNMSASTHLSGVGLQAAVPKSQKLQLLPISNPELGPGAETTQMMRVAGCKGPLRLRLRITYTHPARGQVVDQVNWSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTE6</accession>
    <name>A0A2T4BTE6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1425694</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BTE6"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="75"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1229"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1560"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1574"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB72583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1583" mass="180156" checksum="1A8981229929A7C9" modified="2018-07-18" version="1">MAATYDVGTRAWQPDAAEGWVASELISKNVEGNKTNLVFQLENGETRTVSVSTEILQSGGSDPSLPPLMNPTILEASDDLTNLSHLNEPAVLQAIRLRYLQKEIYTYSGIVLIATNPFARVDSLYVPGMVQVYAGKQRATQAPHLFAIAEEAFMDMIRDGKNQTVVVSGESGAGKTVSAKYIMRYFATRESPENPGARTKRGSETMSETEEQILATNPIMEAFGNAKTTRNDNSSRFGKYIEIMFDNERNIIGAKIRTYLLERSRLVFQPLKERNYHIFYQLVAGASDEEREALHILPIEQFEYLNQGDCPTIDGVDDKAEFDATKKSLTTIGVTDAQQADIFKLLAGLLHLGNVKITASRNDSVLAPNEPSLELACSILGVDAAEFAKWIVKKQLVTRGEKITSNLSQAQAIVVRDSVAKFIYSSLFDWLVEIINHSLATEEVLSRVTSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYLREQIDWTFIDFSDNQPCIDLIEGKMGILSLLDEESRLPMGSDDQFVTKLHHNFATEKKHPFFKKPRFGKSAFTVCHYAVDVTYESEGFIEKNRDTVPDEHMAVLRASSNSFLKQVLDAALAVREKDVASASSTVKPAAGRKIGVAVNRKPTLGGIFRSSLIELMNTINNTDVHYIRCIKPNEAKEAWKFEGPMVLSQLRACGVLETVRISTAGYPTRWTYEEFALRYYMLVHSSQLTSEIRQMADAILKKALGTSTGKGLDKYQLGLTKIFFRAGMLAFLENLRTNRLNECAILIQKNLRAKYYRRRYLEARESIVQTQAVIRAYIARKQALELRTVRAATTIQRVWRGYKQRKEFLRIRKNLILFESVAKGYLRRRNIMETRVGNAALVIQRVWRSRMQLRTWRLYRKRVTLIQSLWRGKCARREYKQMREEARDLKQISYKLENKVVELTQNLGSVKEKNKHLISQVESYEGQLKSWKNRHNALEARTKELQTEANQAGIAVARLQAMEDEMKKLQQAFDESTMNIKRMQEEERELRESLRLTSSELESTKETSLERERDNMSLRQELEALRDALELAKRNGALNGEITNGASSTPAVASGLINLVSSKKPKRRSAGAEPRELDRLSGTYNPRPVSMAVTSTSHRQNLSGATFIPGVDNIEMELESLLADEDGLNEEVTMGLIRNLKIPSPNTNPPPSDKEVLFPSYLINLVTSEMWNNGFVKESERFLANVMQSIQQEVMQHDGDEAINPGAFWLSNVHEMLSFVFLAEDWYQTQKTDNYEYDRLLEIVKHDLESLEFNIYHTWMKVLKKKLQKMIIPAIIESQSLPGFITNESNRFLGKLLQSNSAPAYSMDNLLSLLNSVFRAMKAYYLEDSIITQTITELLHLVGVTAFNDLLMRRNFLSWKRGLQINYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKATLNDIEIIQDICWMLSPNQIQKLLNQYLVADYEQPINGEIMKAVASRVTEKSDVLLLQAVDMEDSGPYEIAEPRVITALETYTPSWLQTPRLKRLAEIVSAQAIAQQEKLEAGEVDGFDGHQQLAEVEESSETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTH7</accession>
    <name>A0A2T4BTH7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1472518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTH7"/>
    <dbReference type="STRING" id="983965.A0A2T4BTH7"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="255" mass="27670" checksum="8BE85FBDFE6780C0" modified="2018-07-18" version="1">MSLHLFCKETGIGRGISLELARRGANVAMVYANPSRHETARKAVEEILSLDSGAKAISIQADLKVFGNYQKIIDETLRELDVRTIDIVVHNAAVASPVSTEDTSEQLYDDTMTTNIRAPFFLTKAMLPHIPRGGRIILISSIAARRFSFGMSQTAYAISKAAIEALARNWAVEFGQSRDITVNALSVGFVETELVQSLSPESLEAYRKENARVTAAAPRSGTPDDIAQIAAFIASEESRWVTGSTVSANGGKWPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTP0</accession>
    <name>A0A2T4BTP0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_7732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTP0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTP0"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF16">
        <property type="entry name" value="GPI-ANCHORED CELL WALL BETA-1,3-ENDOGLUCANASE EGLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="442" mass="46217" checksum="1EF92EA716B31715" modified="2018-07-18" version="1">MPRQQQAFALYPESSQLQIALAIGNGGAPLPTTAIMKLSTTIATGAALVAGVSAGQKNYLGFNSGNTLPDESAKFEKDFLAEFSTAQKLVGAPGTFNAVRLYTNIQAYSKDTPLEAFSAAIKTKTYILLGVWASGTDNIDNELSALSAAVKQYGKDLTDLIIGVSIGSEDLYRDSQTGRTNKAGVGNGPKEILGFINDYKKTFANTALANVPIGHVDTWDAWVNGTNKPVLDAVDWIGVDEYPFYETGKGNDISNAGKLFDTAFETTLGVANGKPVWVTETGWPLTGPDWDEAKPSVKNAQKYWQDIGCKRLFNKYPTFWYNLRDSNPANQVKFGISQSLSSTPSFDLTCPKEETTSASKATATGKDASATTLVKATGTPEAVKSGSEGTANAGGSKSSNSDASTTSSGPAAATTTGAGAVTKVSGAALAGVAMVAGLLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU90</accession>
    <name>A0A2T4BU90_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1472732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU90"/>
    <dbReference type="STRING" id="983965.A0A2T4BU90"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36239" checksum="70A4A816BB76AB74" modified="2018-07-18" version="1">MPPRTSLKSRPPKIIRDHLSPMPSHLLTTTLNDLLRTPSSSSSSPSSTTGHILPQGHHLVYFPLQTPASNLAPDGADKDHAPNEEFTRRLWAGGEVRFHNSKSSDLVLDGRPWLCREEIGDVRVKGDEQGPGSEKVFVDVWRRYALGHDENPGKWDIEERRTLVFMRKADDEAGDVPPKGRLVRYAHTPTHSAALTPTPAHLFHFSALTYNAHAIHLDPGYARSQDGHRALLVHGPLSLALMLRVLNDHLNPSSKSHSDGGGIVKSIVYRNYAPLYVGEEMKVCVKPAKRGAARDEREEEWDVWVEGPEGGLAVKGSVVVDTKRDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUH0</accession>
    <name>A0A2T4BUH0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1441259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUH0"/>
    <dbReference type="STRING" id="983965.A0A2T4BUH0"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB72960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="467" mass="53342" checksum="6EDD1F3D7B60CF88" modified="2018-07-18" version="1">MMPRHHSSGFSNGYPRADTFEISPHRFQPRATLPPHRKRKRTAIRVGIAVVVILVLVLWFGQPKSVASLISLGILSGYDDLKLETVRYYDLSNVQGTARGWEREERILLCVPLRDAEQHLPMFFSHLKNFTYPHNLIDLAFLVSDSKDHTLESLTTHLEAIQADPDPKQPYGEISIIEKDFGQKVNQDVESRHGFAAQASRRKLMAQARNWLLSAALRPYHSWVYWRDVDVETAPFTILEDLMRHNKDVIVPNVWRPLPDWLGGEQPYDLNSWQESETALALADTLDEDAVIVEGYAEYATWRPHLAYLRDPYGDPDMEMEIDGVGGVSILAKAKVFRAGVHFPAFSFEKHAETEGFGKMAKRMRFSVVGLPHYTIWHLYEPSVDDIKHMEEMERERIAREKEEEERKKKEAQIKEEFGDANSQWEQDKQQMQDLKLQDRGGEKEAAAVLGQGAAAKAAGAVEGQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUQ7</accession>
    <name>A0A2T4BUQ7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1340334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BUQ7"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="95"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="207" mass="22233" checksum="E5A5D2B9C375F5FE" modified="2018-07-18" version="1">MATRQVCQRLPLRRIAPRVAASPAIASPARAAAAAATRTFSSVVSAATRPLPSSRWRSVGGVAGARWYSGPESQVPGSRIWGFDEIKALVEKKDPKDKVVIVDVREPHELLDTGKIPGAINIPITSAVQSFHISDEDFEDMYGYARPPKDANLLFYCKAGVRAKAAAGLAQHAGWESVGEYPGSWLDWEANKGPVEVVRGKKGGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUU9</accession>
    <name>A0A2T4BUU9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1072124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUU9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="15780" checksum="A4E0FE8FBCB7BD6C" modified="2018-07-18" version="1">MKRDGAMTANRSVILAPVASSPMPTFLLCRSLNINISVADAKYSPLRKAPSTRVRLSQKEQIVYQKKRNEGRNGKDKRNVAQSGDESKSFPFKLPHDPDVLLDLPSFRKTLLAHAKQLPAFFEELLYPQCINDKQKQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUV5</accession>
    <name>A0A2T4BUV5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1404832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUV5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="15751" checksum="B1CA985800C931BE" modified="2018-07-18" version="1">MSLDANNWATGPFSSARMNASWAQRNVNRLATHVVTNSDRAILLPSGNDYKKSEIQMFHDNVAYSDLATAMHSYRRTEKMSKDMAYLAVETSSNTTEGRECSFSNRCSNGMGWRGKCSRRNMASGGSCKNLGINEMIEGCSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUW6</accession>
    <name>A0A2T4BUW6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rds1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1441371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUW6"/>
    <dbReference type="STRING" id="983965.A0A2T4BUW6"/>
    <dbReference type="OrthoDB" id="2098436at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015642553" description="Protein rds1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51056" checksum="092638AED9A96D40" modified="2018-07-18" version="1">MRLQNAGLLALSNVLLVHAVPRLYTPTTTFSEAETVTPAVVPQTNVTSHGPFTGPPATTTGALSTTVTASSIPALPPAPNSFNYTADGKLHAPQPAPFTPSGGIGTNGSAPVYRVQSDFDYQSLALALYQEWIELDLFHWGLQNFSVEEWEANGINAEERFLIEYMADQEIGHATVISNMLGPQAPKQCTYNYPVSNVREFIDFNQKLTRWGEAGVYGFLPHLNSGPAAQLLLQSITVEARQQLIFRQFGGQFPMPEWHTVGIPQSWAWTLLAPYISSCPFNQTRLVWQNFPALHILNQPNPARINGSAAFNETTGGWANTLSTQNISRSELCLNATNKALDCAPAISQNRSIPLSYPGRQVFLKWDNPGQLVGPNNSYVTSTTVREPKFAAWVSQLNVTYSPLLNVSMRDNTAFTFQPNASTWDHDPAINGTMFLALTDTNLTVTPYNLTMLNPHVAALAVYQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVB1</accession>
    <name>A0A2T4BVB1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1340416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVB1"/>
    <dbReference type="STRING" id="983965.A0A2T4BVB1"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="115" mass="12804" checksum="6FEBD54AE618BD3A" modified="2018-07-18" version="1" fragment="single">MENNPLPPPPKQSLHIPDDQRYLYKPIIGTKSVRFLILQPGSGSDPLIGSLQLGSLDPDDLAQLPPYEAISYVWGTSDRLFTLLCDGAVLPLTQSIRDALARVRLPDRARRLWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWF0</accession>
    <name>A0A2T4BWF0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epstein-barr nuclear antigen 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1441211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWF0"/>
    <dbReference type="STRING" id="983965.A0A2T4BWF0"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="265" mass="28815" checksum="33925D809967B2DE" modified="2018-07-18" version="1">MRCLYQTLVHPKGGYISTKLFVPRDVWRVKGVKIKNVEDKIANCDFLTAALLKLSKVDTLDADAVLEEMQALEGILEQIQPVLARKLGSEVGVQGSGLLFKDASMIEGDGSAVPRSGSVSGKASAFSWRRLRPKTSGVGLGGSYSSRNASAEMKEVATLPTVPMTPKPTSRSAKRDVSQVQFIGPNASYMGSLARLFDAAQAVDQIARQVDDPGLRLADKTQVGLELCTRHAAEFFGFYICRFVLADLGLLLDKFLKRGSEWVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWJ1</accession>
    <name>A0A2T4BWJ1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1381482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWJ1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWJ1"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="543" mass="60975" checksum="12D4CDDBE33CB1E8" modified="2018-07-18" version="1">MASVQPATAGQATSGSHPYTCNSCQVAYRNIDLQKTHMKSDWHRYNLKRRVASLPPITAEIFTEKVLKARADTTAEADKALFERACEPCGKTYFSENAYRNHLLSQKHKQNLANPPKKHDDETTSVMSSTFSLGDPASAAGEDVDSAAEDEFNQVIEGLQRAKVTEQRPSPVKRPSNPHPTPESGNNGTESTPTPTQSGSDRVWTVNTCVFCNHESSSPESNAQHMERIHGMFIPEKTYLVDLEGLIRYLQERVGEEYQCLSCGKYKNSLFAVQTHMRDKGHCKIPYTTDADQLAIGDHYDFRSTYSDGEDDDESDSGSTEDGNGGAKLGGLRETKVTGADGEELEEGEDADGWETDSSASSLDSEDLTAVPAERHIHQFERLSKHAHHSTNDPRSHHQADGWHSKAHKHTKAAFYDEYELHLPSGRSVGHRSLSKYYRQNLYNYPTAEDREEQLLLEGARKEDGVEPNSESQVAVIKNRRREMAPRGAIGMAGVHDAVKRSVRREVERARDVEHYRARKTEWSYAKKRNNQRHYYYRETGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX55</accession>
    <name>A0A2T4BX55_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1055201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX55"/>
    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="142" mass="16355" checksum="AF6B72DF29D2E2D8" modified="2018-07-18" version="1">MLYSLFFLPRSALCSMADGTVFYLLFAMSISGTCSLDYCYLSALSFDEGRFHDCKRKKKARGENGTELLFSVFLFLFVVHSSTWDREGGQWMKGVEETERDLLAEGDRRHTRAWLARMLLYSISPEIILLIFVNSVRILETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY73</accession>
    <name>A0A2T4BY73_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1403618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY73"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="66" mass="7242" checksum="8924BBECD8165403" modified="2018-07-18" version="1">MEGCSIPIVESGHCLTHSTHLTKEFSISIRSNRLMNYGGMVSTIANIPGLDNVTWISIRLSIVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYI0</accession>
    <name>A0A2T4BYI0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1046588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYI0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="183" mass="19906" checksum="AFFF1276F67421A3" modified="2018-07-18" version="1">MTRSNYGEACWAWDSLSGSSSPVFALRLFSRRGSLAPASTGYRVGSTLSSLGQELGMLRLSKAEDRVSQVCGPRCESPERLNDASRDPPPCMRQRPATNCHDGLRKSAQVGVVSLHVLMRRKGPTYIQVRACTVAMDGSNTNRQGRRPPLLRAGSFSSWSHWGSTSCWKSSGRDTQPAKTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ10</accession>
    <name>A0A2T4BZ10_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1049315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ10"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="2">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="208" mass="23067" checksum="53F94EF1A3623396" modified="2018-07-18" version="1">MSAAANAPQKRKQPSPEPASSKKPRTQEPNTLIGPHEATLKELSPAHNVLALSVLSSTQIRKRVTSATSHLLEKASGSRIVLLHARPADVCKMITVAEQCKRVLGEQGQAWYQYNELFDLPPGSAKKKKEKKKENTEPETMEAEEEAEEDSDSDEGAFEAMESRFEKALLPPPRVQTYKSLRIFLSNQAIPDLKSRENVTVQTSEDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZK6</accession>
    <name>A0A2T4BZK6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1336427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZK6"/>
    <dbReference type="STRING" id="983965.A0A2T4BZK6"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="54"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="488" mass="53763" checksum="773D83B23C474BB2" modified="2018-07-18" version="1">MATSATASAAAKSAATTTPSPWLGDEAGALNVDKVLQQVSQDDQDEWEYEYSATETETYYLTVELSYPEFKERPAKAHHHSRGGYYKNWSDQYADHLKLDTKSNDHAVGEQYSNNKEGGNDQGNDQDDEENPEPERDAPGDEQGGIAEDANIDPRLMAMGDNGRKDATDPTKHGSKAKGKGKEKEAETARATTEATADDMEPADEPLEEIQILELHSRNPIISYRGRVFEGQWAEVIGTEAILADREAKDAAQLPALRHLPGGVDILGASSSRLLTTEKILKPKVAQEDSLAPIREEWNIRIPPGKDRTGERAQQLRFLENLIALKKKRGDPDEVTVYALDGPGKDFDDRKGPDFKPRRKKPSLGVDQGNGVNQDERRERRYTRRSLGRRGGRRRRASAARGGAAATDTGNGSALDSNALSTPTPSHWDELFGIQEDEDEDGSINDISEDSDGPERRRASSGEDNDDDDEADEDDNDNDNDGDVMMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZT5</accession>
    <name>A0A2T4BZT5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_104696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BZT5"/>
    <dbReference type="OrthoDB" id="5413982at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="202"/>
        </location>
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            <begin position="204"/>
            <end position="220"/>
        </location>
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        <location>
            <begin position="226"/>
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        </location>
    </feature>
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            <begin position="293"/>
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        </location>
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            <begin position="384"/>
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        </location>
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        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62354" checksum="508FC0E12E1BCAEF" modified="2018-07-18" version="1">MADAAELERQKQEKIAAAKKRVEQLKKKKKKGAKSETKAEAEASAPDAAEATSEQPQPTEPEVKDDKPAEDDQPAEDNAAIEEPKAEEEAEDKAVESPPSETPSLAQQSKLRSTSFRAGSNAGSGPMSPGPFSPEGGDTAADIYRKHVARIEELEKENKRLTKDATDSEKRWKKAEEELADLRESDTKGGKDDQTEKLKDEIASLQRQNSQLQQQVSRNSGHAHRQSVSISASPPSLQAELDAKSATIESMEIEISKLKARVERQESGASSEKEQIAALEDKVARAEAAAGKAQRELQDLKKDLERTAEKAVREGSERTSAETKAKTLERELEETKQAKEELEKKVEALEKKVTALTTLHKEQDARSQALRKDKEKAEIEVQELRSKVEKLESENAKLASRKSTDGGGGLDDEGVDELEDEGRRKLEKRIRSLEAEIHELRSGAWIERRREMEATSPGFDDVDLSGNNHAPTRKRASTAGGIGEFIAHGLNALAGGGDDDLLDDDDVEFDEEAFRKAHEEESKRRIERIKEIKRSLKHWEGWRLDIVDVRRGGGQGIGDIFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C048</accession>
    <name>A0A2T4C048_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1393233</name>
    </gene>
    <organism evidence="3 4">
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C048"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="257" mass="28296" checksum="21CE31298278123C" modified="2018-07-18" version="1">MAVPEDPETGAFDTSTLPAEKPALGPIPDASAKEQKLQIAEDVEDISANAEASSSFTGHQLFYIFGVHGIGALIISGGINLAIAYATKPIRLWQLPNTLAGDAAVTIIIQCIITWFVEMLILRFDLSQRSVRPIGFISPPSNSLLRSFFFLPRDATAEAKKQPRKWSLIEVIQQALRGFCFAVVGFLLLWPVFVGALTAFGDKEGGDYYYHRKWLPEIFKLVLGGVLGLLTTPWMAMFWLVKAGWEERADVAVVPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0I5</accession>
    <name>A0A2T4C0I5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1268289</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0I5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="58" mass="6491" checksum="6900DB6D188C4821" modified="2018-07-18" version="1">MINSWFGYYRAANPLQYCITVLDLVDWMGVMDRGDVGFVSSRLFASWASATLPTRGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0X4</accession>
    <name>A0A2T4C0X4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1402766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0X4"/>
    <dbReference type="STRING" id="983965.A0A2T4C0X4"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="320" mass="36064" checksum="77A4D290FC4CC56B" modified="2018-07-18" version="1">MEWFGERVRTPYQATVHERTSAAYPGHYSTSESAREHTSTHAQPSPDARHGQRRYKPRTCRICLDTVEPRYPPNSRSSKPTYVSDDPELGKLLSPCKCKGSQKYVHEGCLNAWRLSNPTVKRNYWQCPTCKFSYRLVRLHWASMLSSKWAQAGLTVLILLTSIFFLGFMADPLLNLWVDPVGTVTEAVTSVVTDIEALREPDWEPPTTWAEHFVKGFFSLGLVGIFKSMLALSPWHWWNLRSMTGTGRRQGTGRARVENIGLFFVLMGAFTALVGIWKGVRKLSERLLKNVSERVLDVDGDDGDVDDDGDDGIPGAKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Z9</accession>
    <name>A0A2T4C0Z9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1439752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Z9"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Z9"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="884" mass="96835" checksum="86392869A3710FD0" modified="2018-07-18" version="1">MDSSSRAYQKAPAYPRASSRTSNRSSSHARTTSQGVRSPPPHFAAPQFSDHPTHRFHHTPCNKPLLSPRSTPRNTPPPIREGSVEPTRTQAVSSFLQEKLQRERRAESDKLSQSPLSRVNEDLGASVELGRVSSPRRRSVAASSDGSRPKSSGGSGIELVKKPGLGVKDMEHVISSLHKQNFDLKLELYHRREKQSLLETTIESLERDKRQTEEMNETLLDELEKRDKAVEEAVAMIVMLEAKVDQLVQERNMVMQVEQEGFFCPQDMDQKYLRPTLQVPSDDASRKSETFKSINRVPSFLSEKSENTENLRSVYLGVKGSALSLARVTEGAPDADNGPSNGPGSPTLSVLSESSFASVYGKKSQDSIFPPPLDQPLSLDSADADLQTLSTGRRDASRKISPSGYPPRAASANHFVGGSRSSLGARHSVSGAVDHVSPLQQIEKLGRSQSVLQEGFRPVTSQGRDRRRSQPPPTLRKVMTDGPGSVRLHDPNFPPTPDTISTSTLHRMRNSNDSLAKQDSRNDRSSGVYSDSDSQPLQVSFRNKPSHLRGEADKSSRGSAPMHRHQRASSETVSQKKDNRWDSTDSDEHSDARSHRSSLDIWMRESTNSNGGAASSDLFSLPSTKKSQGIDNDADYIQELFSLRQSLVTNTAPPPPDRRSSLHARTSSTTSSVRNSPRTLTLTSTPEEHEYSDDYSGHSRQQSEGVQMRSEVHTPAQSPSIPQHPHSEKRGQYPPITGPRTALNRLFRRSLVPSSPSNIPASATEATFADATKANQGVSLQPWLNSDIAGQLDDRAGATPPPIMLKPRHMRRNTIGVDAAPAFIPSSTSAPVRLSDMVASGRDSPSARKQAVEPAPPAPSVIGTRRKWLPGFSRTGSSLRNRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1C8</accession>
    <name>A0A2T4C1C8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1C8"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08621">
        <property type="entry name" value="PI-PLCXDc_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015761001" evidence="1">
        <location>
            <begin position="24"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="600" mass="65970" checksum="06375C401DBA1F9F" modified="2018-07-18" version="1">MRYSHLVASLGWLLAAGSTVVNGLCNPQNVTYSNESPPNGTYMPWVLMGAINNVPGARQYVTIVNLTPHRFVLQNTHSYQMDVFDWGDVPQGHARQNTVVYTSKAGKNAVDDGGEAYYAIDGTDKTFMIRAATHIPDAHPTRTVIDLTGMGLGQREYLDPANQSPVTLVITGSDSYGFITSIRFGAGNWMKNIYPVIKDRQIQHVVMPGSHDAGMSTISNKLMGGGISENTQTQGINIYNQLWAGSRYFDLRIGSVHSITDNSDYSFWTLHVSGELNEIALGNSGESLDDVISEINQFTAESPGEVIFFRVRYLVGIREVPSLGPIYWTTDMVNDFFGKLRGVNNRCGNLDTTRTFNQKPASYFMDQNGGNGCVIFLLAGDLTSDVPQDSIADGIYKADQLSIADDWSNMGNTQDMAEDQASDWKAVSRGGSSDTFHISQWLVSADFVTTTFFTIESIGILPTNPALYWMGVNNMSPQSWPTVILVDYIGVVVKGQHSWDQLSAELYTLAIGLNLYMISENCDVSTVASPLLPAGRSAMRLSTMAKPWNGIHYANGTIVDDAPRDSHPGRLEILRKGTRFMNGTVIDHDIVNPYYNSTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1D1</accession>
    <name>A0A2T4C1D1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">M440DRAFT_1379562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1D1"/>
    <dbReference type="STRING" id="983965.A0A2T4C1D1"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="280" mass="30872" checksum="A953C72761052A07" modified="2018-07-18" version="1">MSPSKPAHLDPSELGTKEYWDKLYATELTNHAANPSDTGTNWFDDSNAEGRIVAYLGGLLEDDDDKNREILAGRKEPLTQEGAAILDLGCGNGELLFALRDDGWEGTMLGVDYSAQSVELARRIGATRDAVDAADDEEEKKEEAEGKQVPPVNFLEWNLLTGPLSPSDPSSPLHFAPSPESLFDIVLDKGTFDAISLSATSSPNETHPCEIYRQRLLQLLNPRGGIFLVTSCNWTEKELRGWFEDDKDGELRVVGRVEYPTFTFGGMKGQTISTLCFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1F4</accession>
    <name>A0A2T4C1F4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1431847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1F4"/>
    <dbReference type="STRING" id="983965.A0A2T4C1F4"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845:SF1">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52082" checksum="0BBF3180DCBD6B2E" modified="2018-07-18" version="1">MAFEPYQLSEVLAIANVHPFYVAGSQYPPDQTVVQSLTKKVKNEKEAENDSLSSRPLIWKKDLYNTIQRLVNDTDPDNTYRRSVYASITGGGFGSKPLFFGTDVYENRKQRAHFGRFLQTIGVLEPEDWALTTHCAGELYRSLDLMLEIMENAGASVLSAGNVMPPHEVAKLLAKYHINVFAGDSSQVVQMVHHISTLPEEERALIKLDKIIYTSEVLTSAQRAHIMETLKDVKIYSILGSAEAGPWAASNPDVTGRVSTTSEEDLVFDTRAMLLEVFPSSLAPGDVNVEPLPEGESGMVVQTSLSRLRNPLVRYVTGDIGSVHPLPESSRERIPAEDWPYLRILRLQGRDRRVSFDWDGEYIQFEDMAALLNNEECGVLQWQIILDKLEPSLESFLEVRLMCSPRTSRVLSQEALVDRIKGFLHVVSTNEYRFKMTFVDALDGFVRSTTGRKVIKFVNRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1H7</accession>
    <name>A0A2T4C1H7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1335773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1H7"/>
    <dbReference type="STRING" id="983965.A0A2T4C1H7"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="410" mass="45251" checksum="760187E2735A835F" modified="2018-07-18" version="1">MSTPSPPIAIIGAGLSGLTLALALHAHSIPSKLYESRPSPLDIGGAIMLSPNALKILDTLGVYKHIASLGFQFEKLSFRSHDDTPIDDFGFGSRDKHGFKALRIYRYQLINVLLSMVRNAGIPIEYNKKFSHVTYETPENITWSFADGSSATARLLIGADGIHSRVRKHIHPNLTPNFTNMIGVTAAVPRAQLQAGPEYPLPVTIMSPQHGAFVIAPQRADGSEVLIGKQKRLEQEYDRAGWDELLENKSWCVDFLRQGSQDFPPIVANAVSDIPLEGINLWPFYLVPKLDTWTKGRVVILGDAAHAIPPTAGQGVNQAFEDVYTFAGVLARTTEQCQFPEGGRDAVRMSAALKKWQLGRQARVDKVLELNDRLNKRRLPDAGEADDLEPFDLDWLYGVGFEESIAEWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C213</accession>
    <name>A0A2T4C213_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C213"/>
    <dbReference type="OrthoDB" id="4879927at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="17677" checksum="5C8EE1BFC7A65383" modified="2018-07-18" version="1">MSLQTLIRLIVGTSSRASWNTRSPILQLPAEIILCIADHLALQDLFILSQVCRALRRLVHRDWNTELFLLRPRDQYRFWVGLSLVRPAFWACGRCCSMHRVSGDGSDSRPIAWAPSVPGWRRLPCGAHYRERGRSVVARELSSSESELDEGGFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3L6</accession>
    <name>A0A2T4C3L6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1247095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3L6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015668288" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21368" checksum="84F51E0972D77BF4" modified="2018-07-18" version="1">MSRDGAMLLLLLLLVERQRATTPRFRARAGLRVCRQSMGGLRGDDAITALLCIFCVFRFRGGAPLRRGNKDVREGGGRGGSEVVGVVTAVTARCVASYRSRTLRGNYRGRRRRRRAYRIEMRRKRTELVGYGERSSECRYFLRHGIPTRRSKDVAMACHADAQAVAQEVCMDCRHRRDRGKIPIYSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3S5</accession>
    <name>A0A2T4C3S5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase DHX8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3S5"/>
    <dbReference type="STRING" id="983965.A0A2T4C3S5"/>
    <dbReference type="OrthoDB" id="413653at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25545" checksum="A5ACFE7FBB873B91" modified="2018-07-18" version="1">MSRPSDIPHRQIRASHDKDHIIVYQAYKPSIASAAVKAQKLNASEEFSPGRMTWIKPSWCWMMYRSGYSYKDDNQSHILALKMKMEHFLELLRQGVLSDHPSEHARVDRESTNKTAHERPSDVRIQWDPERNARLEALPYRSIQIGIPPNLSKKWADEWIVGIEDVTERARELKRVLEEEPNIEEDELVKRGLVPEETPVDVPDDIMTRLDMTVLGVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4L3</accession>
    <name>A0A2T4C4L3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1401934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4L3"/>
    <dbReference type="STRING" id="983965.A0A2T4C4L3"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="22377" checksum="FAD9AF9A6BB00310" modified="2018-07-18" version="1">MASHHDDETMPEETQGYKLSQPKQSIAEYHQMDAGDESLQRYKQSLGLGGGKDLSDPNDPRVCIILSLTMDSPGRDPVTIDLSSAGSETTLKDKPFKIKEGAKFTMSAEFKVQHEILSGLHYVQVVKRKGVRVSKDSEMIGSYAPNTDKQPTYVKKFQEEEAPSGMLARGHYNAISSFVDDDKKKHLEFEWSFDISKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4N4</accession>
    <name>A0A2T4C4N4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="9">HIBADH</shortName>
            <ecNumber evidence="3 9">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1401935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3 9"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4N4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4N4"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000630">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="10">
        <location>
            <begin position="27"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="332" mass="35439" checksum="1F26FCEEA5197BE9" modified="2018-07-18" version="1">MRVVVTRLGSLVQRRGFASTQRRLDNYAFIGLGQMGYQMAKNLQSKLKPSDKVAIFDVNPTAMEGLSAEMNAKPDGAAVELAASAHDASKDADTVVTCLPEPHHVRGVYESILTDSLPKKDRIFIDCSTIDPTTSRQVAQSVSDAGQGTFVDAPMSGGVVGATAGTLTFMLGADPNVLPRVEPTLLLMGRKVLHCGAQGAGLSAKLANNYLLALNNIATAEAMNLGIRCGLDAKTLANVLNVSTGRCWPSEVNNPVKGVVETAPASRDYRGGFGISLMKKDLRLALVAAEAAQARTELGKLAFDMYDQAAQREDCKDRDFSVVYRFLGGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C566</accession>
    <name>A0A2T4C566_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1438469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C566"/>
    <dbReference type="STRING" id="983965.A0A2T4C566"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="196"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="528"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="279"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="748" mass="82604" checksum="DD499C75F16C11A2" modified="2018-07-18" version="1">MEAEIRAVLPNIDPVVSDYSVGYLTHASTAWSDEDSEAHVSPLNEAASLITELLVSASGDPAQEEKIKQLVEKWVDKYAEANGGERRGPTAIRRLDQTIQVSSQRNMSSTLAVAGGAVDLESANVRKVESKVDRKKLEKAERKIAAKQQKKTFKTVEYEASRLLEQPEDAQSYEEFYMAVNPLQLGASGANKTKDIKLDNIDVSIGANRILTDTTLTLAYGHRYGLVGNNGVGKSTLLRALSRREVPIPTHISILHVEQEITGDDTPALQAVLDADVWRKVLLREQEELTARLADLEAQRAPLADTSADAARLDLEKETLDTKLGDVQAKLAEMESDKAESRAASILAGLGFSPERQQYPTKTFSGGWRMRLALARALFCEPDLLLLDEPSNMLDVPSITFLSNYLQDYPSTVLVVSHDRAFLNEVATDIIHQHSQRLDYYRGANFESFYATREERKKVAKREYEKQMAERAHLQAFIDKFRYNAAKSSEAQSRIKKLEKMPVLEPPEKEYDVKFQFPEVEKLSPPIIQMSGVSFGYSADKPLLSNVDLDVQLDSRIGIVGPNGAGKTTVLKLLVGKLEPTKGLVTSHPRLRIGFFAQHHVDSLDLTMSAVSFMAKAYPGRTDEEYRRQLGAFGITGTTGLQKMVQLSGGQKSRVAFACLALTQPHILVLDEPSNHLDIEAMDALAEALNEFQGGVLMVSHDVTMLQTVCTSLWVCDGGTVEKFDGTVQQYKKKIAAQADAAGVVKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C589</accession>
    <name>A0A2T4C589_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1231988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C589"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="144" mass="16414" checksum="5F151FFCDE907C05" modified="2018-07-18" version="1">MPGTRDEQYAALGKSPQAVSRTDTEYNEGLEKTSTECDAMRATSYLRYTLKRRNTPQYPSGHTKKASCLHRETPRERQRAEQQGLTNISRNPRQPHRAGHRSSAKRPFPPNSHPNMRGGPQLAISNIITGLRPSTRFKFHLYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5U6</accession>
    <name>A0A2T4C5U6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1238694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5U6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="97" mass="10943" checksum="06E416367EBC1BD3" modified="2018-07-18" version="1">MADSSRDRAVAWQKLRQSPLGRVIVTLPLTLTLTRAGESGSNALLRPSRTSRACCWSGRKRELRVWIGSSLPRSRIEWRRQGRAEEGDGDGRPKQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Z9</accession>
    <name>A0A2T4C5Z9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1332642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Z9"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="32"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="206"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="413"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="783"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="886" mass="99793" checksum="725B1878CE8EE6AB" modified="2018-07-18" version="1">MGNFISWLDRNLAPDENQGSARESQPQSAWGMVDTLVPVLVVSSIYIIIFLFLRRSQRRFYAPRTYLGSIREDERTPSVPSNWLTWFAAFWKIPDAYVLTHQSLDAYLFLRFLRICFIVCLVSLLITWPILFPINATGGKHLSQLEILSYSDIDINIHRNYLYAHTFVGWAVYGFLMYMITRECIFYINLRQAHHINPHNAKRISARTVLFTSVPDEYNNEERIRGMFGGVKRVWVCGKTKELDDLVEKRDEAAMKLEKGEISLLKLVNKARTKAQKKGEVQPEGPASANTADGDIETGNIASRWIPDKKRPHHRLGPLGLIGKKVDTIEWSRSELQRLIPEVDKAQADWRLGNYEKVRAVFVEFETQGEAQFAYQSVTHHEALHMDPKAIGVQPGEVIWKNLALPWWQVIIRHYVVYAFIAALIIFWAIPVGIVGLIAQVNTLKSIPGLTWIGDIPKPILGVISGLLPAVALSVLMSLVPVIMRLCARLAGEVSQSRIELFTQSSYFFFQLIQVFLIQTFTNAASTALVQIAQQPGQVFNILSTALPTASNFYISYFIVQGLTIATSVVTQVVGFFVFTLLYKLLAKTPRAMYKKWTSLSALSWGSLLPVYTNIAVISITYSVIAPLILFWSTITMGLFYLAYRYNILFVTETRIDTHGLIYPRALKQLFAGIYLAEICMVGLFSVSKAAGPAVLMAIFLVFTILYHITLSRTLDPLLFGLPRTLQAEEEALEQRTGGKAGTSVEEGLASNNVSHDDANGKGSVPNFAPRASAKRGNFILRFLKPWIYSDYHTLRQLFLTEEHLAQPTQYAEEIEAEAYLPPSVASKTPILWIPADPAGLSKQEIAASSKVIPITDEGAELDEKNHIKWDAEGARPPIWEEKVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C608</accession>
    <name>A0A2T4C608_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argonaute siRNA chaperone complex subunit Arb1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1332569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C608"/>
    <dbReference type="STRING" id="983965.A0A2T4C608"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53241" checksum="3DF3F1F2F43CF3A5" modified="2018-07-18" version="1">MPEIDESVAPTKHLLPGDIEGESEDEAGDDAEDDAPGPPITPAELSAPRKKRKRSKKTTASRGPTALPKNRGHGFEEYFADPPMTPAEAMQEKQEIYAPDIPFERRIESCIQRFRSRRRIQARRATYLNDYLFLGGVDTNPSAYTGLDQKDLKQLTPAQRREATARDVVYEGSGAGDRFYDGDKTKWAVDFAGVAAGFFSTRLIVLTGLHPKPMEEAISVVENFLRYVLHHDVCPEYEDNVKEALRICQMARDEWTALNTLQTALPGLFNPAATELFVEFDPCSWDTSHFKAPEGFDAKSVFYSSIAMLDDSKLFEHLAGKDVKLVNQYECALEVTKVHLPTEEVIERFKKLAITAADKTLRLMPLGKLTLKPATIEDGWVHQGTAHPLQGKEIDLYFEQDILASLKPGVKMVLEIGELGADIRFVKDIQKITPSFYTFLPQELMVQFKLPQKNDRPAPSVHNPTLEDNQAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C619</accession>
    <name>A0A2T4C619_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1332625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C619"/>
    <dbReference type="STRING" id="983965.A0A2T4C619"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="380" mass="41722" checksum="1D56DFBE3A5663A7" modified="2018-07-18" version="1">MAGILAGDSPIMGLSGMMQHQELGPAAGMGMGSLVGCGTAFNATALNYQPGMPAPMYRYTPNLDFQQADATLNPARSFREDLFSGTNPLVAQSGSDTIAPGGGFDSPYLQQDGPSHTILPGSQSAEREDTDGSLLAAFLLQDETALSESLLMNIRKNKITLKDVLRKGLQSLERDSQTATRPADGSVQGRVLYKVMQVQLPDLHTNTIRVTQMSFVAAVLHNATMLGVTASQMFEYEAESPFCASKKAPGASTEGLAFTNIKDDLKPTQNQLTQRHHPYIDALPFRAFRERLIALMYAEPPIINREELCHDLQNDGVVCWGSFAGAGTGHSGAPWDIRSWEVRPWFLKKYWMITEGAQGEMYQQARWWCELRGEDVPTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C660</accession>
    <name>A0A2T4C660_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1299404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C660"/>
    <dbReference type="STRING" id="983965.A0A2T4C660"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="16474" checksum="5CDE6F1F56FD1906" modified="2018-07-18" version="1" fragment="single">AAEYGHDSIVKLLLDTGLVEIDAPDCCYQTPLAFAAEWGREAVAKLLLDTGKVQINARDSHHHTPLSWASENGHPAVVKLLLDTGQAEVNVEDKYKRTPLSFTAENGHEAVVKLLLAAKDIVTDAKDVAGRTALCYAAYRGHATVVKLLLDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C691</accession>
    <name>A0A2T4C691_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1401393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C691"/>
    <dbReference type="STRING" id="983965.A0A2T4C691"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="63"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="432" mass="49131" checksum="D2C67518194BA195" modified="2018-07-18" version="1">MSPTDPEAPPTASNGDAAARIGPHPGYISSSNQYASELKIRRMLRENGCDPAREDNYRLQGVQLIDTVRQHLNLPVRTFDTACTYFHKFRLNFRDAEYNYQDAALASLFVACKVEDTIKKSRDILAAAYNVKNPDKPAASDDKIFESPGKIIIGLERLILETIGFDFRTRYPQKLLVKVVRSILGREAGESFFKIAYAMSIDMYKTFVPIKRTTFSMVMALVELTARMTGQHLDAVKEFAARRPQYHRPAVLETMLDILDLYVQYHKSTKVGTQFDLNRFMDIKIALNTELEKDFISRHMYHCSRCENEDPTPATPGSATSPTATLSSWPGDLSMRRTARGQDGTMRFVFDPEAAREEQDTVAPYFNEEYEEYEVEVEEPIPPPQHEHEGGGRGGYRGHGHGPRDRSDYRRGGSYGGGYRGADRHYRGRRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6N0</accession>
    <name>A0A2T4C6N0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_51315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6N0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6N0"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="5">
        <location>
            <begin position="343"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="539" mass="57907" checksum="504E31FD684B394D" modified="2018-07-18" version="1">MSHKGKNSASSAKGKKPSKAGAESKGEDVLQAVCLLPLANTPLIEYTLEFLAMNGVQEVYIYCGAHTDQVEDYIGRSRWAPSSKSCPFSVLQFVRVADARSIGDVLRDMDKRSLVDGDFLLVHGDMVSNLILDSALAAHRKRREMSAANIMTMILHSGGTEEHRTKTKGITPVFVVDTKTQRCLHYDEMNPLQSDHYLAVSQSILAGNVVVGKGCTIPAGSLISYGVRISDGIAFSTAAVLSTVTSTGKPVTADASLVGPDGNAAPFYDPEDDELDDEDPSRLQKSLIYSLANYNLSSSSISTLASDADSDSDDDMDGNNLLSADAANSSRSRLSSFASDDSAGKMSFHADAVHGLLDALRADSGDFDSAKLEFMGLRLANNASDAMMRKAVATAFVRRAVELVSPEQHRGGLDPSKAAERAFTACRGAPKFVNEVGVGLGGGEAAQVEFVLALQRALSHYYAKGQEQKTATLLPAMLQQLYALDILEEEGILGWWADPRAVDGEAMAALKEKCRVLVEWLENAEEEDEDDDDDDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C700</accession>
    <name>A0A2T4C700_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1330166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C700"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="79" mass="8748" checksum="F3FE862583AD0B63" modified="2018-07-18" version="1">MASHRDPSAGLGKAVDDISCVLMRHVMSPQMPYIFALQLSSIVISVSAEKAKHDLKGSQRMRSIKLRLEITHSSVAWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Q2</accession>
    <name>A0A2T4C7Q2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1390884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Q2"/>
    <dbReference type="STRING" id="983965.A0A2T4C7Q2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="98"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="342" mass="37380" checksum="C967D3DA08ED8849" modified="2018-07-18" version="1">MSSEKHEALQPLHPSMAGKLDPAFVKLYNENVATKPPQPIDLAQLRRSYSVLYSYGTAPAPDVGRVYDDVIPLADGTELPVRVYEPDEGRPGPWPVHVDFHGGGWGLGDLDSESHICRHYCHKAGVAVVDVAYRLVPEAPFPTGITDSFAAVRHIRERGAERFNVRPDSISVGGVSAGGCIALAVAHLARDAGIPLRLVAAGTPVIDDLSQYASAADSPWPSMRENEFAPTLNWARLAWFDRLKLSSLAPGDKERLGWFANLLKAPDFRGLAPTLVFTAGADPLRDEGERYAQVLVENGVEVTQRRFLGVPHPFMHMDAALPQARDCIDTTARYIRMAHYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7V8</accession>
    <name>A0A2T4C7V8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_3796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C7V8"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="361"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="898"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1758"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1758"/>
            <end position="1787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1927" mass="216252" checksum="5CD33EFFAEAD9957" modified="2018-07-18" version="1">MFNLELVWLSRATPHVDLVFVHGFGGTPETTWHDESTGKVWIKDEEFITRIKRPIRIFSFSYNGDVDANLSASSPAFQANDLLCCLEQALGESPGRPLIFIAHGFGGIIVKKAIQLCFLSPSYPRTKNALAGVVFFGTPHADTNSEALLQAVRGTIDAFGSGDEVTSQDIREFVSIVSRINSAFIACKPSYLRLLSFWEKLPSRAGASSADSHKSPVIPLQCRKEELQGNTDHMIDCSHEELPRFSSTFSDRFMQFMQIFSQFLVDTLAERTVATVSTPITRTLSLSPERSFPIEEISGIEKHDFPIIRPRRRMWRIENDDRSRERNNKENKDATARDHFLRSLRGWSEANYGNEIFVTAGTCEWFKDGFIYKNWLTDPKCCTIFYIGAPGHGKSHLARAVYTHLKSSKPDDIVMGYFCQREEEKPAIWEYFTWQLIKEWPDWFFHIPIQFRRSVVDEASPPRLDPSAYAEIWTSFRRICSPRTIYLIVDGLEQTPPANFAEFFAMVEQLRQPIALGPEKRSSNVIEIPTKIKLVITSRWTDATFTASSTTSCCSLPEDDLKKDVSLYLDKKFLAISNSRPKSEHGLIQKIKQQVNEEAAGYWLYAKLAADEIEGLCGQNSIHELQTDYIPTKLARLYEQKMLPLLQSVNNSERHLRTVLTLIASEDVGLAFSLKQIQDFLECLYGPDDMPAGSLAESIRAYCGDLFWVSPADSLVLSVHASVRSHLNGYLSVEHRHTNIVLVCLTYLLQDRFCSRLPLTDRESTGERMANTAPFYGFAAQGWLSYLAKLETLSPQQKSPLERFLSLDCPQYQTWLHWRSWLVIENAQGIPSAIEDPIMTMVREGCVAVIQHFFPFSASPLVPWMAEPENWLRNIPFIHKRPSGGQVGRQWPNIKGLHGHTLLMAAALSGSRVMVEHILQWKADRNARDEGGRTALLLCLTSERLMGPKAQAQKANLHGIVEALLLNGNSPNISDYRGITPLHVACVRGRLDLVRLLLRFHALVNVTDAWGYTPLDRAYSTGDVALVELLLIRGGADAEAWMLGGEPPLARCIYDGKLDMFKAFLPFASINQTTVFGLAPIHLASDGADRIDFLRALLPRPGLTLDAVSSLTERFKTKRTTALGFAINSRNHTALELLLEAGAYPGLLPRVSVPPLHDAVTVQDRSMVELLLLYEAPVNSFMHSYFPHTALGHAVDLGLEPIVELLLRNGADASMQEGYGVAALIETAVTREGPPIPKILRRLLDSRHPPNANYIRDGEEHCIAGAVDQGDVETVSLLLEHGADLSVYLESGKAVSPLHKAAGQGNVEMCDILLKHEPRLLDLQLEKGFMIESPLFEACHQKKKDTVRFLLDKGAKADQVSYYYKESPLFTACDVGDLDVVKMLLEATPHMVNVPTAFDCTPLAYACEHGDPEMVKLLIDVGAEIYLKGSDTTSAFSRIFEAKGDKPFKIIQLLLSSGLDLHAVNNETGLTVLGLAIVDAEARHVKWLLEHGANPLRAQRVPRAEGKWRTALQVAAHTTNENIMPIVDLLLEQHWGLWDHLTHKDYHGGTLLPVMGRSRKNLQVISRLVSACDTVFQETGKDVFSAIVDEPNLIGLTPVDCAMNALEAKPAALPELDKLIVSRIDELLAGPRTTEKHLLALDYVVGLLLARGGCESDTAVLAEYILTRPRARWDDDSCYMGSVALQSCFICDEAIYEPYVYCILCESSWCAECKDKRDVISLHEHKWLPMNLRKDLDINAPDIQETLERLRKQLTPTFYGDQSESPQRSDQQSNEVNSPIGDQTNEEQPLPSLAKPQISLPLATLHAFNFLAISRPIWTPFLPLTPTAQALIGPWLAHWSEKDEYRRWKGLMERRTMDYENSAQRRLQEMQYLKRGFSRAYADYEGVKRDLVLFDVRRLFLGEEGGGDGRPVVAKDRLVKVVRRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C805</accession>
    <name>A0A2T4C805_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1221827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C805"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="92" mass="10401" checksum="498350761955AE21" modified="2018-07-18" version="1">MILVSAEQWACLSSFCPFILFLAPSSFNSFSAFSFVVPVCSTFLFLFGFRRQGKLRLSRKIWDSAFVGQTQKKARIRSDGINVILCFSCTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C830</accession>
    <name>A0A2T4C830_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1221048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C830"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="70" mass="7580" checksum="486F3CF741D9DB6F" modified="2018-07-18" version="1">MPSGVELEPLAGDVALSTDFLSLIHLTRYAALMPHPPPNHPMLDDETALGSDFIMSKTRHFAAGLENLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C889</accession>
    <name>A0A2T4C889_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_291973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C889"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="17054" checksum="3902482FE037B2FA" modified="2018-07-18" version="1">MRRLPPPLENFKAAGFASHPLCDRLVGRQFGSRETWLRRGCRFSSNNFSDSRRPLTASSDFPIRSHGYLWLAFRLGLVPALPVSCTVPYCGTLIDASRKSQLAAKEARKVTPPLERFSSPAEKKKICRVVENLFFSSSSTQRPTLSQTPPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C981</accession>
    <name>A0A2T4C981_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1399314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C981"/>
    <dbReference type="STRING" id="983965.A0A2T4C981"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="27220" checksum="C6CA95B73A6CB093" modified="2018-07-18" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALETIDLDKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGKKHQTNLARRAAREQREGKQNIDPATGLPASVAANLTARRNVVKIGRPGYKITKIRDPVTRQQGLLFQLQYPDATPDLAPKWQVMNAFTQRAEEPDKNFQYLVVAAEPYESVGFKIPARELDKREDKQFSFWDPDSKEYWIQVMFMTEREERFNAAPGLTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C989</accession>
    <name>A0A2T4C989_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Nup120/160</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1328119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C989"/>
    <dbReference type="STRING" id="983965.A0A2T4C989"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="73"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="7">
        <location>
            <begin position="828"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1159" mass="130466" checksum="0A495A1E9C7D4D63" modified="2018-07-18" version="1">MDSSDLQYLYKETRLNLEPPSPSSVVTIRVPAGSGSRGRPKLSHDAEDETTFRLKNLATAASIYRRKWHDSPRNFLWRVLEDGTLLSIRAVDVSKKDKAADASLIINFHFTAPIQPGCVVFSDPEEHDALCVHVLDQACYLYTFTLRPDLFKRRGAVDAGLPDICKVQSPSGLTFKYPHRMVAVSANTLLVTVNDGGMIRFDRQKGDDASNALWKESFFNVQGWAQNLRSLLPFHGKHTIKYGKANMEYSTATSIDISDFGLDNCLFAVTVCLDHRIRIWNANDGQILQTLDMLNVERPPQELGKWSIDPAQSNLLRVVGRTRGQRICATYSPIGPGEFKFWKITAKDAHNVVIEDLFSKCSLIPVTPSSSDIWTLADFVLASSGEGQISLWTLWKNNMTYRVQRLELDRKNMAQSWEDSWDGVYSEPRSLSVQTSGPCDPTDVTEKWLQMILQPGRFTKATLETALAIYERGLGAPRENNKGRGLAEAICSVLGSTATLDRGSMGEMDYEQFRSSSEIQWRRFYRLLNELDKQRGEAIGMAFDADADMVWVVCADLISSVRECSHLERLYHNIATPDQGSLRQADLIGAGLTLVEGFPDNVVQTCTAALRHELFEESTKTDLQRIQYFSDKAGFWRGITEEDAQQVVETLDTNFAAVTNELYRKVLGLMVTPLDDRSRSPNHPLTEFGRKLVMTAAQDNIALQWKVCFSQLILLVHMEYEFDSEEEILHNRIDVGTVFRQLLAILKRLELLKWLSQTELAIPLPEHSLSSLTKRGEDVQVVTALEANVGHLLGLQGLPGEPLPICITDLVTNLCSPNGDIEVSPSLIQCSLIKRDRADLALELEPFCDQNPFSIYIHGRVLLALKDFESASFKFRKAAVGMGNTTVELERHSSGLLDDTEWNLLNSGMAQYYSHIVALFEKQRAYSYVVEFARLSMQFIGSKPENASIKTDMLSRLFNAALATSQFELAHTTLLSMKDEALRHYNLRKLVDKMCETYHNSELVTLPFPGMQQEVDDILSLRCKTIMDVMHAFPYHQVLYSWRIKRNNYRGAASVILDKIQKLRLAGEGDQITGEDVLDTPVTRQYLLLINALSCVDAKQAWIFDEGVPEGEKNKAAAAKRKVVSLADIRKQYQDELDRIAAIQNNQFGFEAGDVMDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9M5</accession>
    <name>A0A2T4C9M5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1327854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9M5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9M5"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="236"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="337" mass="37682" checksum="0AC0DDC64BAC4E74" modified="2018-07-18" version="1">MASGQNPYSQGPSQESGYGGGAGGYGQLNPYATNASDNASPYGGSNNYEMQDYNNQGTAGGNGYAQEQASRQPAVLSQQDFLNRVQNLRNDIKALTGDIDYIGQLHQRTLSTTDQEATQQLEHYVAQTQIRNTAIKDGIKGLERDLLKTNDSSRNTKKTQLESLKTFFKSELDKYQSIERDYQQRYREQIARQYRIVNPDASEDEVRQATEADWNNEGVFQTALRTNRTGHAASLLGNVRARHNELQRIEQTLSELAILFQELAAMVEQQENVVVSAEVNAENTVQNIEKGNEQVSQGIEHARRTRRLKWWCFLICFLIVLAIALGVGLGVALTNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA92</accession>
    <name>A0A2T4CA92_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1420572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA92"/>
    <dbReference type="STRING" id="983965.A0A2T4CA92"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="227" mass="25026" checksum="23E0DF77B32C94CD" modified="2018-07-18" version="1">MSPPNADDASSPITKSLAIDIVASTRPMHTRINKLITSRVPLALPPRSSDASAYISGMLHFLPVYMAFEKLWLDVTSTPPSGEEKANDTPLDAESADGLPRGTDSKDGHIEVSERVRTILVALYMPQLFRSDRLRGDIRSMTGWSDEVLDRQIHTIKGTGQLSAFLSHIKQAVHAKPHVLIAYSYNLLMALFAGGRYIRASLEKAGSDFWETVPEPIKPTMQPFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAA7</accession>
    <name>A0A2T4CAA7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1194014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAA7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="234" mass="25530" checksum="CE550687CF70B7F6" modified="2018-07-18" version="1">MPETQRLRPHWCEISSSPRLSEFLSLRSSPYAQRRSVGGMGMAPGNGWAAIWPGIWSDSKTTINHVFGVAATTGGPCHVVPTNWPLGEGKKSLLKLRSTTRPTKHRAVRRLAYSGDVLPFLDLTVPQNRKITMFAPRCSDRRCVGKSADGAAKSTGESREATRSNRSRYELLTTRTGGSEGGGGGGLGSKSRCYRTLCNGTAVIAHRTSMYASFRLPKTGGLKSRCSFHSRRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAU6</accession>
    <name>A0A2T4CAU6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_18152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAU6"/>
    <dbReference type="STRING" id="983965.A0A2T4CAU6"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="468" mass="51416" checksum="6C2B398792CC6B18" modified="2018-07-18" version="1">MASETPKLLWNTENVKDVAESVGIGSMSDEALKALTQDVEYRIGQVIIEALRLMRAARRTTMTVNDVSLALKVLDAEPLYGYDSTRPLRYGEASLGPGQPLFYIEDEEVDFEKLINAPLPKVPRDMNFTAHWLAIEGVQPSIPQNPTSAELRPQDLLPKGPGANPALSALAGNDTGAGQPAVKHIVSKELILYFDKIQAAILDDNPDEEVVRLRQAALGSVRDDPGLHQLVPYFINFIMDRVTHQLDDTFTLKQMMELTNALIENKSLFLDPYASSLSAPVLTCLMARKLGTDEGQDALKEQYDLRQLAASLLGRIARKYSASNSLLRPKLTRTCLKYFLDPTKPPAVLYGAIHGLLEAGGMEAIRVLVLRNLKSFDAGILQPLKEKSEGSIEYEMLVQGIVQAVASLAQRKETADGPDAQMNGVNGNIPAQELADLNDFIGPIVGQKIASSRNHHLIRTILDARFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB57</accession>
    <name>A0A2T4CB57_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1437599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB57"/>
    <dbReference type="STRING" id="983965.A0A2T4CB57"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF315">
        <property type="entry name" value="ACYLTRANSFERASE EASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52079" checksum="0F915841EF2406BB" modified="2018-07-18" version="1">MGSIASFSEKTLVRPSIPLVPGRTSVTPLDQYMVRVILPMMVFFKVDEPSLRPIILDNLKKGLSRAIDELNILAADIIPLDPKDDTIQLEYHKDSGVWFHVKELPDVDYEDLARRNFPFSALPASQFAPSPLGHSARSPVMTLQATLINGGVVLTFGGHHVVMDAQGMGTFVAVWAKHVAAVSEGLVVPDEQLMGNESLDAFQLFGPRMERPLSEFPTYQVGPDRSYEDMQAKVLQKAVAGDHEGIAKLIRVSHWAMSQAKLDALRDAAVPRTKEEASVTANATLSALIWKQVSRARRLTEKQVSQSSLITSVNVRRRVEPPLAPEYPGNAIALAKANATAEELEAPGVESLYALAKKVTASIDWWTADELWSLTGALQTCGDVANKLLPPLNYDVLVTAPARLGDMLKAARWGSELGDIKALRWAFPAFMDGFVIVLPSIHDGIEIMLWTAPDTTERLKEDSEWTQWVTQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBQ2</accession>
    <name>A0A2T4CBQ2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNA polymerase III transcription initiation factor B complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1419419</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBQ2"/>
    <dbReference type="STRING" id="983965.A0A2T4CBQ2"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="143"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="241"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="729" mass="80891" checksum="5654F658235EFFF0" modified="2018-07-18" version="1">MSFLTPPPKRPAGQGSVPSKPRFARPNPVRALREREERSHASALARASSIQRPGVVTPAHQQCANKACPKPNVVDGTCQTCGRVADDSNIVSEVQFGETSSGAAMVQGTFVGADQAGVRGMGPAFRRVGGSEDREKSIREARGLMQGYAQQLNISDSLVTAGTQVFKLASSANFIQGRTLASVAAVCLYAACRAEPPCKVMLIDLADLVQLNVFKLGRIFKKLNEVVPIGADGLIPVYPEDLIWRFATKMEFHQDTAKVAEDAVRLVKRMSRDWMVMGRRPSGICGACLLMAARMHNFRRTIREVVYIVKVTNHTIQNRLQEFNNTESSRMSVEDFLKQDFLESSHDPPSFYRKSDEYRKKAEERSRKRKRGITGEALEDQSPEEAPAKRHVEGGADLSKAPEVNYRRDADGFIIPPLPSQIPQGNVSLNPSKDENEDGPEGLEDLAQEFGDALDQEDAADQEAGGRGKGKRAKPQLPINEEWEQDEQELEGVIEEIFNDPLTYEHALAYSTAEQRARIHSLWARQQQPQKEVSMAADVTEDEFADDPEVINCLLSPEEARIKEIIWVNQNKDWLRKHQEKVFRRKMEAERPKQTRKRRKRARMGEGQTSPASSAAEAAIGVAKDRAWSKRINYDAIRSIFDIPNVGLGSAATSRKTSLAGSTFGADDDASEAPDESVAGDDVQEHEEEEYEEPEEYGEGEEFGGGGEYEGGYDEDDPEMDNAYGLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC11</accession>
    <name>A0A2T4CC11_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1327565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC11"/>
    <dbReference type="STRING" id="983965.A0A2T4CC11"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="42366" checksum="87446CC35E001710" modified="2018-07-18" version="1">MPAPAYPLPASPSPIQLYRHLLRECSYLPPVFRTEITSTIQDRFHRHRKHDPRAKAHLARARTALRTLRAANSGDKAAMEGLIFKGFGRSGSRRRELMAKFVIPQGPKDSSALEKVLTSPDAEGEGAAEDLAKGVPKAKKAFFDKWDQDKLLRILKSQRQQQRDTKGTASWLGNPVKTIDPDQFIPQQTIWGKPPCEALKQTKRAHWWRRNADKIMPPLGRGEWEILKELTAGAQERGEWQIPARRPLATSPAATEEMAARAQWNWKEYATKPAAIVEKPKALKQQRRTGQKDNGPYGVKDRDRELSKRWFQRAYSRTWQLTPTMTQDPNTLRYSFTWGSLSPRIPPAAKHQLDIFEGVDERGRKQAKSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC12</accession>
    <name>A0A2T4CC12_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1436467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC12"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="557" mass="59490" checksum="D4852EC02D1B8735" modified="2018-07-18" version="1">MDSKTPVPSIGDNYDGLDEKREDKPDEKREETTVDSPVQNEELAEDEYPSGLKMFFIVLALVLSVFLLSLDMTIVATAIPKITDEFKGLDKAGWYGAAFFMTVGAFQSTWGKAYKYFPLKATFLTSIIIFELGSVICGAAPNAEALITGRAIAGLGAAGIGAGAYTIIAFSAPPKKRPAFTGIIGASYGFASVIGPLLGGAFTDHVSWRWCFYINLPIGGVSAAIIFIFFQTPRNAVPVKATMLEKIRQMDPLGVILMMGATISFILAVQYGGIAHPWDSSVVIGLLVGFVLIIGAWAFVQWWQDEYSMVPPKLFAKRTNLVMSLVAFIQAGGFFAAIYYIPIYFQSVHGTNPTMSGVRNLPFIIAVSFSTVASGMLVSATGWYQPLLLGGTSVATIGAGLLYTLGRNTSTGKWIGYQIVAGAGWGTAFQIPMIAVQALADPKDLGPSTGMLLFFQGLGGAFLVSGAQSAFINTMVRNVLQHAPQVSEAMLVLTGATEIRNKFPADQQPFVIDGYMAGLRVVFAMCVACTGLATLIGLGMRWQRLNPDALKNAGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC75</accession>
    <name>A0A2T4CC75_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1460806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC75"/>
    <dbReference type="OrthoDB" id="5398371at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="475" mass="52963" checksum="A5858031A72C81A2" modified="2018-07-18" version="1">MDEAAAAPAEAEAEPSSAKLERLGLGPEVVAVADAGDIVLDVTFETSKETLRKTGKATAYAARKPGGAPQPTLKTKVRVAYRVSQAALKKHSKYFNNLLSNSSFREAGLIAEAHKKLADRGIKPAEADAADLPWITITDDDEATKAAGREHAFEDMLRIMHQKPPKTARVALQDAATIAILADRFDCITLVARSILNGVRWPVTTTKPYTDESGRVTDAEETLRQKVLVSLLLGNGMKLHQAARELITRGSRLWSDFQDHDESLTAAWWHLPDGIEEELQYRRQCVLNTIASAQRHFLDLYCSKERQCKLGYDSSVACDSFQLGQMVKFLTSKNLLYLVDYTPASLERVPDAATVNIDELLATLKQCPSYQVDKNHTNCGLRTRLEPIVDYIRAMLSASGTSIAHADWKKRRSEVSWTMLRDGQDTGDTHEEPRVFVFTRSVANDQRLRYENAMYTDRLSKSLFTASSWDWTPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCA5</accession>
    <name>A0A2T4CCA5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1398466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCA5"/>
    <dbReference type="STRING" id="983965.A0A2T4CCA5"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11404">
        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="383"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="451" mass="49417" checksum="3F439BDFBE8B5FAA" modified="2018-07-18" version="1">MGSSQPDSDPFQMPFGYSVDGAQEPLFEPPEPAPGAPLLSETDNKFLSDFFDDVAANQYNMPSFGEGLNFNAWFDLPPQFMGTATSYGSQASAPLGPEPHLTYSNDSHNPHVAISGSHLMPPPPPPPPASQSTAYQQHPSDDVLNAAATLMQNGSGLRGAHKNLDPSTPRRPLGPPVGHLRHQPLEEFREESRKSMAHIEVDNTFAEWMWGSKGRQNSTPRAIPVDYQWGSDSNFNLHQGYTPGANKETVELQQQEQLKCLECLEPNKSAATTRPSSPTNSQSTFSVGLHRDVSEAAERPADNDDDAPPRKRRKSKIKKDSTEEGDDEGINAIKPAGGKRRKAKSERTESVSSPPTEAGSTGKRRKSALSAAKTPRENLSEEQKRENHIRSEQKRRTLIKEGFDDLCEIVPGLRGGGFSKSTMLTMTAEWLEELLLGNRELTAQLAAIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD78</accession>
    <name>A0A2T4CD78_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD78"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="87" mass="9676" checksum="03D97484A4B94CE8" modified="2018-07-18" version="1">MPYFSGQSFSSHSRSSQSSSHHYPLHHPTSPQRQSPTSPPPEPPSLKKTHNSRISISVQPSAMQIHDFPSQTLNNPDSRPSKHPKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDB3</accession>
    <name>A0A2T4CDB3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_240414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDB3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="125" mass="14044" checksum="BC561B49950E7AEC" modified="2018-07-18" version="1">MLRPGAWWHERIRAKAGFFVLSRGSLLIRRTTAADLGIGGSSARSRPCRRPFFCFLFFSFTCEDLHVYYHSTSLLGVSDITRALSAGLEPITLAVKSFPSPFQLRVWFPSLAGAYLCEPRKKATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDQ0</accession>
    <name>A0A2T4CDQ0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1436890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDQ0"/>
    <dbReference type="STRING" id="983965.A0A2T4CDQ0"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="123"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="269"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB79658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="360" mass="39449" checksum="56266C7F561FF424" modified="2018-07-18" version="1">MIDAAVPPTNDVDLKSRAKTRSWDYVWRSGVAGGIAGCAAKTTVAPLDRVKILFQTSNPQFAKYTGSSFGVASAMKDIYLSEGVRGLFRGHSATLLRIFPYAGIKFLAYEQIRSFIIPDKHHETPFRRLISGSLAGVTSVFFTYPLEVVRVRLAFETRRDGRSSLTSICRQIYNEHPVEKTRTVKPPNAPGIATVVDSAAAAVESVAPRVGLVNFYRGFAPTMLGMLPYAGVSFLTHDTMSDLLRLPSIAQYTTLPKKKNHPEGKAAPLRSWAELTAGGVAGMISQTSSYPLEVVRRRMQVGGAVGDGRRLRVGETAAMIFRERGLRGFFVGLTIGYVKVIPLAAVSFYTYERMKLVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE20</accession>
    <name>A0A2T4CE20_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_17592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE20"/>
    <dbReference type="STRING" id="983965.A0A2T4CE20"/>
    <dbReference type="OrthoDB" id="10066125at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="2">
        <location>
            <begin position="246"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="313" mass="33815" checksum="9241C1A5E335B2DF" modified="2018-07-18" version="1">MPSSAQDAASAQAKHDHRTIPHKLCKTSLAHHCNCAERKLAKKARKAARKAEEPQLKGAAEVYQESAAQGKKEKNKKDAEVQEQVLELEKKRHHHLAESKKLEIQVELLLKQAHNAAKVLAWVAKALDGAPPDYASPRIKSDDDDVSDADSSDGKNTGTVMKDAVDAPQATSKTDGEKKKKKKDKKKPKIKREETSSDEGQVGGGKRKHQDDDAEQPANKKGKKAKESKGGEKEAHATAEEVKIEGLEGGKARQDKFLRLLGGKKAGVSVAKPGSIASKNQGKSVRAEAAIQQQFEAGMALKESGQKRRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEE9</accession>
    <name>A0A2T4CEE9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1223-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_46735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEE9"/>
    <dbReference type="OrthoDB" id="938668at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010634">
        <property type="entry name" value="DUF1223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36057">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36057:SF1">
        <property type="entry name" value="LIPOPROTEIN LIPID ATTACHMENT SITE-LIKE PROTEIN, PUTATIVE (DUF1223)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06764">
        <property type="entry name" value="DUF1223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="261" mass="28409" checksum="7D3848A58952C7BA" modified="2018-07-18" version="1">MASILRRLFRRQKQPPLVCAVNLDADGNPVGEHPDHVHTDACFINFEPLAVAELFQSQSCQSCPPALPGIHAATADPNVLLLTYPVTLFDHTGWKDTFSSLANDARQRAYAKRWARTSLFTPQIVVNGVADGTGRTKEEIQQIIQQGRDIVKARDWHIYMDANDTEVRVDTDRQEAPPHEVSLVVYANIDQTVKVGKGVNKGKKINHRNVVTSVTKIGDWVGGNAIWSLPTPRSALAPDQGAAVIITEGGVGGPIIAAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CES8</accession>
    <name>A0A2T4CES8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1418704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CES8"/>
    <dbReference type="STRING" id="983965.A0A2T4CES8"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="16493" checksum="57026F20E86C954D" modified="2018-07-18" version="1">MSKAKGAAAGVDTIVKLIVGAGQASPSPPVGPALGSKGVKSMDFCKEFNARTAHIVPGTPMPCRVTVRPDRSFTFDVRTPQTSWLLLNAVGAPVGKKGNRKGVSKPGHETVGTVSLKHIYEIAKIKQSELRLSGLSLEGLCRSIIFQCKSIGINVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF57</accession>
    <name>A0A2T4CF57_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1397504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF57"/>
    <dbReference type="STRING" id="983965.A0A2T4CF57"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18031" checksum="E7C1D72D40BF5448" modified="2018-07-18" version="1">MGHSYGKRAGTRYAFSRDFRRKGMIALNTYLKVYHVGDIVDIKANGAVQKGMPYKVYHGKTGVIYNVTKSAVGIIIYKKVKHRYIEKRINVRIEHIQPSRSREDFIKRVKANAAAKKQARADGVTVQVKRQPALPRDASTVSLTDNPPETVTPLAYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFG0</accession>
    <name>A0A2T4CFG0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CT20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1325055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFG0"/>
    <dbReference type="STRING" id="983965.A0A2T4CFG0"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="286" mass="31681" checksum="8E1610D39BC0E2F0" modified="2018-07-18" version="1">MPPKKRSRLQVSSTPTTIREDSVMDVDTPRPSATPGFLSSAFKPIIPVTPYDSLWTDDQISSLFKGVIRWKPAGMHKHFRMIAISEHLRNHGIDPDIHRHTRIPHIWEKLRTYYNLDLIDEREYFDDDETDDKYVEFSLPFHEFGEMMLQRAVADPSEAPTSPPQLDLSPPPEQKRRRASTAPKTRGASVEGAESSVAASPALKPAKGTRGRKRAASQSKAGKEKVVENSEEDDDESEEEDESGSEESDSESAESGSPAPKPARGGPGRGRGRGRGRGRRGRGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFH4</accession>
    <name>A0A2T4CFH4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1325322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFH4"/>
    <dbReference type="STRING" id="983965.A0A2T4CFH4"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="233" mass="26969" checksum="62F147F3B18E2621" modified="2018-07-18" version="1">MTVTDGNKSGKPVLFFDIDNCLYPRSSKVQDLMAELIDKYFSEHLSLPWDEAVKLHKEYYTNYGLAIEGLVRHHQIDPLEYNAKVDDALPLEDLIKPNPELRQLLEDIDRSKVRLWLFTNAYVNHGRRVVRLLGIDDLFEGLTFCDYSEVPLVCKPHEDMFKKAMKQAGVERVEDCYFVDDSFANCAAAKKLGWTAAHLVEEDVPAPKVQASQYQIRHLRELRQVYPQFFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFI2</accession>
    <name>A0A2T4CFI2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1397647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFI2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="91" mass="9934" checksum="0617AB83C3975B02" modified="2018-07-18" version="1">MAHEKGHGTLHLSASLGCFHLSRFRVALTMVRIDSPQAVAGPIRCWRDETKKSARQAVRRSGAEQVLVLGLLGKARELQKAGARMQDVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG22</accession>
    <name>A0A2T4CG22_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1369742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG22"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="324" mass="36786" checksum="C2BE238366718EC6" modified="2018-07-18" version="1">MGLLTFLGLRRENQWERLTLLDKLLLSPLTFITIKLYHILLFLRGRPFVPPRNRPAIRVVCISDTHDQFVDIPPGDILIHAGDLTNSGTAADIQKQLDWLKSQPHQVKIVVAGNHDSWFDTRSRLDSDVKAGATVNLDGLHYLESGLTVQEVKGRKLTLFGVPDIPECGPESFAFQYPPHNPPWFSRIPPQTDILVTHCPPKHHMDLGLGDSHLLQEVWRVKPRLHVFGHVHWGYGKESVFFDEMQLAYERLLSRPRRGPFWDFVPNAAWWDHLYVLLHGVHAVLWKWIMSGPGSNQGGCLMVNAAQMYGSTGKVKSRAVVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGT6</accession>
    <name>A0A2T4CGT6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1134197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGT6"/>
    <dbReference type="STRING" id="983965.A0A2T4CGT6"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33542" checksum="D190B4839F64FB49" modified="2018-07-18" version="1">MADSLQELLSNLDDEIQDTDEETFLLYANTVPLEGLGFIDSRASMLEIQLNGKDVTIHQSPGVLASSRKGGTTGAVLWKITPLFAEWLSSPSNPLTPFLTQQTSSPPSIIELGCGISPLNALSLSHKVSRYILTDQPYVQKLLLQNLAANIQTFSSSSTTKAHPTAAAEIHFSVLDWETSQVTPFLTHSPTTSSFDAVVSCDCVYNYALIEPFVQTCVDICALRNKDTSALRSNQQQDSADGNLLRPCLCIVAQQLRNDDVFHTWLTAFRRRFRVWRVPGGRMPVELRPEAGFVVHVGILKDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGU6</accession>
    <name>A0A2T4CGU6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Root hair defective 3 GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">M440DRAFT_1324497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGU6"/>
    <dbReference type="STRING" id="983965.A0A2T4CGU6"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="764"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="788"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="47"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="825"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB80742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="857" mass="95726" checksum="28B36038D93CFD9A" modified="2018-07-18" version="1">MNGHFSAVGDQPANGNYDHGCQVIDEEKEFNRNLNDYLQTMHVTEAGFNYHLISVFGSQSTGKSTLLNHLFGTTFSVMSETERRQTTKGIWLSKNKRETSAGTKMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLLVNIWEHQVGLYQGANMGLLKTVFEVNLQLFQKDKNSTPRSLLFFVIRDHIGVTPLSALQNTLIQDLQKIWSSISKPEGLEQSRIEDYFDFGFAALPHKILQGEKFESEVAQLGARFTTGHRVAKGGDGGVAETEGGILLPEYHRRIPADGLSVYAEGIWDQIVNNKDLDLPTQQELLAQFRCDEISREVLVAFDQQLTPLEEKQTQASKLGKAVVLPDLGSIASEAREKCFKAFEVQASRYHKGVYARKKQELESKVDGRLKTLYQGQIAAAHKAGVAAFSEAVANKVKAGQKAGGGYEFAEIVSNEKKKTMDIFKAEVDSLAIEGVEWTNFAAQNQLFEAELDEVSSKLRKDEIRRLATRVERWVKSRLGDAVGLEFNKLGTGRGGSGAPEEGEKPASEKDLWDRIWNVFTGVVSEAEARFSDRAKSFDASDAEVEVGLWRLRRKSWTALREKIEEEVMEGNILMKLRENFEDKFRYDEAGVPRIWRPTDDIEGIYTRARESTLTLIPLLAKFKLLSSQAPPDLIGFIGPQPSGVEAGDEEDLAPIGGVDEEEGKSLEEEMTMLSENKRQDLVVRFKKTADGVYVEAKRSAIGGMTQVPWYFYVLLLVLGWNEIWMVLRNPFMFILLILLGGGTYTAWYLNLLGPMMQMGNAAVGQGLDIAKQQLRDFVANSDTARQALAMPARQDSDISMDTLDSRGRRRTTGQASQPDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGV7</accession>
    <name>A0A2T4CGV7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGV7"/>
    <dbReference type="STRING" id="983965.A0A2T4CGV7"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="49"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="472" mass="51690" checksum="B1B64EDFCFFAFC2B" modified="2018-07-18" version="1">MSPSPPSSTPQKKKQINLLRGWPSPSLLPAHLLSSATQRILASPATSVPLLQYAPDEGYQPLRERLAEWLGRHYGVKPDANRICVTGGASQNLACILQSFTDPAWTRAVWMVAPCYHLAGAIFEDAGFRGRLRAVPEDEEGVDVGELERRMEAWEREEEEKGVRPEPFKDPGPFRKLYRHVIYAVPTCSNPSGKTMSLARRQALVRIARAHDALIISDDVYDFLQWPLISGGLPTPERPSEMRLPRLCDVDMALGRADNDPRGFGHTVSNGSFSKIAGPGVRTGWAEGTPAFALGLSKTGSSMSGGAPSGLCAGMMAELLQSGELVDFIETKTRPALQRRHGIMMDAVREYLEPLGVVARESSVKGGGVYGGYFVWLTLTRGPLAVMVSDAALSEENVVVGRGSMFAVKGDEGGARFDENIRLCFSWEPEEDLVEGVKRLGELIRRMQGNMGHYERLAAQTKDSDRPVSSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGX5</accession>
    <name>A0A2T4CGX5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1398156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGX5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGX5"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50878" checksum="ABDC14732A547DDE" modified="2018-07-18" version="1">MGELADYLVQHDANFRKSRLPALYSDFRPQKTLNPDGYQANISAWLLALARLASEGLLARQGSQSSALVFDLDESLRKSLASKQFGQPLALGAVINEALAQKDLVPLQTFLHANHNIYQHSWSQIPWDVMGWTLRQLGVIDPARGEDRIPKGNYVVMKNVETASRELGEIIGETAPRYDRVFTRGQFQALFTAVLGQDQRLSDTDTDVLLKFLSRDKDMIEYDGQTVRIRASGEARGITQEDSSMASIKELMGSLEHQIDLLNKRIDEQDQEARNAVLRKNRVAALAALKAKKRAESYLATRYATLNQLETVAAKLQQASDQVQLVKVMESSASALKNLNAQLGGADKVESTMVRLREEMSATDELSAILAEPTGMVVDEEEIDEELEALEKEQKREEEEKQRTREEKQRSKDEEQEAVKAMKALNELPAVPTGDEPERVGSPTKETGIARLTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHL5</accession>
    <name>A0A2T4CHL5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1006721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHL5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="156" mass="17543" checksum="F3227365F813EC70" modified="2018-07-18" version="1">MALTWINWRQRYRTRQLDCPRRKEQYVCDQADERKEIEMETIVTLSLVLPRRTAEVDPAVRLHCSSSVARAQGTRQLQLGTQPLRGESDGAGLPGIQLLSFPGSRSGVIPRQVTKVVMRYYPLKPLAKLTRALKLQSRFCPLLASHGCRAAADATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHT9</accession>
    <name>A0A2T4CHT9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_77396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHT9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="321" mass="34786" checksum="E7D0DFA4DEE1410C" modified="2018-07-18" version="1">MPLLSPLSRAPFAAGWPYRRRTCSCTASPRPSSAAANHSFGLRASARGSTTDWLLRRGRARTEARQLGSTSAPALAQACTGYFDFAIAAAAHPPARAMTCDPSPISRHQKGPCRQAHRALFALLLETSIPRPLHFLCLWTLSLALLNNPPSTCATTDRRAGKASGSGSGSGSGSLWLCVRVQQEGIRFSAPATHRIAAASASPESAWVLSAGRFWADQRWFLLFSPFTSSDQPAGSSSSAVLLPFFSRFVIDSRKEDFLDLRYSLSSCYGFFFCEDVAQSILSPDSVERQVSHGVLLLFSCFPSLRCHPLPLSCLFRLPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHU2</accession>
    <name>A0A2T4CHU2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1007763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHU2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="23051" checksum="C2DA6938E3F6A254" modified="2018-07-18" version="1">MAGLRLERCCRAHRRGGNSFCLPRAYIGRYLCGDRSWSTTNSRYNALEMSISDMTGALQLPQACAREMRPNLHEQARGSTSTTHGSLSLLHVSALAPTARGCHGEACAGTATHTGRATSWRGSLNTHGDTTASSPPAPLALFHAVVPGEAIYPAKCIWSFVSLALCVCCRYARNAQRERKEAPEVASRRGRVFFIFDANAVIRGVGEDFHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI18</accession>
    <name>A0A2T4CI18_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_63239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI18"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="14"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="493" mass="53465" checksum="67F3FBDFC23D9640" modified="2018-07-18" version="1">MANRPGSLLHEACFLFVVSMAQFLGQTGLALSVIAAHIIGQSWDNVSDSQLSWFAAAFALTNGTFILVAGRLGDLYGHRRLFIVGFAWYGLWFLLGGFSAYATTSTLFICCRAFQGVGAGLVLPNAVAILGRTYPPGRRKELVFSLFGATAPAGFNVAGLFIALLAQRVWWPWSYWIMAIFCFSLAIAGIFVIPVTLDPLPTTTSGLGKQGRVLDFIERVDVPGAVLGITGLALINFAWNQAPIVGWATPYTYVLLIVGFLFLGGFGFVERKARFPLLPTSVFTGDLGWALSCIAAGWASFGIGLFYYYQFMEVIEGDEPLIVVAKWAPAPIMGVIAGLTTAYLLSRVSPSVIMFMAMCGFLIASTLLATIPVHQTYWAQAFVLTVVYPFGMDMSFPAGCILLSNAMPREHQGLAASLIATTINYSISVSLGFAGTIETQLNRHGKDLLRGYRSALYFSVGLAGFGMILTLLFMFVSWRRSRRPAKSRTPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI33</accession>
    <name>A0A2T4CI33_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1010306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI33"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="184" mass="20443" checksum="27E54885E8F839BA" modified="2018-07-18" version="1">MGSWLSLLSSRTYSHVLVLHAVIHGHGRGRRCTCMDVRKCKTPLPGEPAGCDKSQCSPFTNKDPSHVVSPTLCHRPPYHSVLSPLLFLKGSKMSYLKLTTGRLPSLSGAVSYGRTDRSTEAAEWQSQMRYPRSWMPSVSRLKVPVSERCALPCRQSGHSPSSSSRLVMQREARGLNGYSSHYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIL3</accession>
    <name>A0A2T4CIL3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1466909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIL3"/>
    <dbReference type="STRING" id="983965.A0A2T4CIL3"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="51547" checksum="23AAB076FB69FC9D" modified="2018-07-18" version="1">MSERQNQRLIEAEGQTHGNLRCLDASTSKSFMDMPNEIMCMIIGFLPRPWTLSLGLTCKFLSKVTEGEFRTRLEGLDRVKFLTTLQKDVANAYYCYCCDRLRRLDPSHDWKIQHHAGGTSDFKNSRWLPDIHHILHVRLPKNLFLLLSKANISFMEPYLVMNRHFLGLSHGISLQSLERYVAYEAVINLDRCSNFLGPVTNYRVSLVHTDLEPCLKRKTQLPGRRLEAAPRREDAWRFTFRMTPKIIDDKLFIRRAYTIVGPLVSQEALQRLIETMSIPICSHLSASASPSCCHPGSDLPTDHVHRCPVIRYRQFFYRRWNDRRVAENEPGHSSCVLCSTDYEMSLKRETLSNETHLSITTWHCLGSCRSPDDELWSHFVSALEHPSFWATAITFSSDDGSQSPVHRYTPQQDSKYPDRPQEYTCLIPESYNGAVRRTWIEAADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIM9</accession>
    <name>A0A2T4CIM9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1323256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIM9"/>
    <dbReference type="STRING" id="983965.A0A2T4CIM9"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="45"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="617" mass="68257" checksum="194BD909FF5A9BCB" modified="2018-07-18" version="1">MPDKTTSVVSYAAGASLAAAALFYVFGPTFTIDHDTTSSRKKTIVGLRNQANDCFINSVLQALAGLPELRVYLIRETHRRRIEDPSVYAHLVQPQDGKELAQWKLQGLQDGLVTYGLKEMLDALNERPISKKAISPFPFVKVLEMAFKQRISRQQQDAQEFLQIVAERLKDEYHAGQRARLHARRQGLAALAEPNQAKDGNETDRSDDAAENPDGTEASGSGTQIPITVDLAEVQRAVREIQAAPEPQEGFPLEGKYESHIQCQTCGYTTKPREETFCTLTLAVPQVSSTTLNACFDGIFKTEYIDDFKCEMCRLVQTKTSLEQEMAKSTSDSFRALAQENIQKLQAAMDVDPERPPEDVELGDIRYAPKRRIAKTTRISTFPKILAIHLSRSIYGIGQITQKNSAKVSFPEQLPLGSVMKQRKYKLLGVVTHRGGHNSGHYEAFRRQNTPSPYANINPFQPSDIYSKTPTPISTPHISALRSDSPSISTPDLLSPSSDTTPSTPSLESNGAPPRSVPADLPGSLANGKDRDGETSSLRSFTASTKSALSKLAPPRASLNGSSSPSVGKPQPRPKKRRPADKWWRVSDEKVREAKTSEVLGMQKEVYLLFYELEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJF3</accession>
    <name>A0A2T4CJF3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 95 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1020683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJF3"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF0">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015675192" evidence="1">
        <location>
            <begin position="21"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="4">
        <location>
            <begin position="287"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="3">
        <location>
            <begin position="706"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="794" mass="84914" checksum="417C73401230EEFD" modified="2018-07-18" version="1">MAKLSLQALLVGLLASSASSALDGSRYLWYTSPATDWETGVLPIGNSRLGGAIFGGGNEVITINEDTLWDGPLQDRIPANGLAALPKVRQMLLANNLTDAGNLVLSQMTPAVSGERQFSYLGNLNLDFGHGSGISNYIRSLDTRQGNSSVSYTFNGVTYTREYVASAPVGVIAARFTASKAGALSVSATFSRVSNILNNVASTSGGVNTVTLQGTSGQSQNPILFTGKARFVPQGGSVSASGGTLSITGATVIDVFIDVETNYRYPTASALAAEVDNKINKAVSQGFQKVHDDAIADSSALLGRANINLGTSPNGIANQPTDQRIKAARSAFNDPQLIVLAWNYGRHLLVASSRDTPAAIDMPPNLQGVWNNATSAPWGGKFTININTEMNLWPAGQTNLIETQLPLFDLLKVAQPRGQEMAQKLYGCNGTVFHHNLDVWGDPAPTDNYTSSTMWPMGATWLVQHMMEQYRFTGDLDFLRNTAYPYLLDISKFLQCYTFTWQGNRVTGPSLSPENTYVVPQGANVAGQQEPMDMAPEMDNQLMRDVMSAIVEAAAALGISSSDANVKAASGFLPLIRTPRIGSYGQILEWRAEYPETDPGHRHLSPLYGLHPSSQFSPLVNGTLSAAAKALLDHRVAGGSGSTGWSRTWLMNQYARLFSGPDVWKHVVAWFATYPTPNLWNTNDGSTFQIDGNFGFTSGVTEMLLQSQTGTVHLLPALPGSNLPVGNVRGLLARGGFEVDIDWQGGGFKSATVTSTRGGQLKLRVADGRSFNVNGVKYNGAISTTAGAKYSITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJI6</accession>
    <name>A0A2T4CJI6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1368011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJI6"/>
    <dbReference type="STRING" id="983965.A0A2T4CJI6"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="764"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1184" mass="132115" checksum="A78B8274E840AF4A" modified="2018-07-18" version="1">MPRHNGSEKRTRIAKACILCQTHKTKCDGLCPCGQCIKRERSSTCSYSSHRRLYGRQRPGPKEADIDVPRETKITTIKIEETQDDRLDPGLREQDGIHIAIPKVPNTMRDTKGRAMYYGDCAALSFLRNIQELIQGEEELAEVAKEISSFSVLAEAPPTDGESVLAYSNANLKDLEDLIQVFFTSTCGMLDIINRATVETLLSRWISGNISVTSSSSAILYLVLALAALIRSASALDEHRSRSFFYHGRRIALLELTEYPTMETVQAFSLISLYMLGSCRRDGGYMNLGTAISAAKALGYHRAESTFPQCPEDRLLRKRVWRSLCVFDILLCAMIGRAPMTSAMDSAEEDFEDYRQRPDAKHPDKCQELGLYESARAISILKQTLLEIYTKRSAPLELLQRLSSKLRQMGTELPFEIRSISPAAFSDNKCPKTRQLIIRNATVACNYYFSMMMLTRPFLIACLRAKYSKSPTTTVGSEMRDSEESSEVDKSVKFGAMTSFDTALKTIQLLHELYVAGVLYNNMPLAVGWTFVSALTVCAAYFGCLGDAKECELAIYRANQILQHFMQNNQQARQYESILKKLSRVALRSISGAEDQPYGNSSRVFWSDLFRLTPAHLHQMKEEEKEESCDGVPCNMGRQEGGLAMVDGEGVSSEEGGSLQDETPLDEGLGDIFHFPDDAYKDFANYTLMTEGLFPEQHDFALDQPLSAPHFPAISRSRTPHLITTRIRIMSTSRLADNADEPTQPFSPPGHDRILQRLSEVQAERDDGEINGNGDDGDARDHVHDDEMTLSDSSDGHTCDGNMVYHNNAVTWNDVGNQKQRGDGIHLDIFLDTMSNTCLFKLYCSVLHKGSKAKGQKHTLFLFIHPESVREITLSNGRSSGPSTSKPSRPMLSFSLTQRPSLVVPKGHVLETKEQSKGALNIILALAQATEFTLHLNNSNLNSPLKKSRLELIARKFSPDSVSSRPLTNERCAHLGSLYAGRGGEVIDIDKATGALTDEADAPPSYAGPAHGQTPQNKRRRIDSPIDKGKSPAVENDLFSFIRTSFDTMENRLCARIDSMAGQIKTQLDDFGTRLDKVEIRLRQLEDTVTDAIDHDHSASIQGEISEQLDDCITGIKVETEEVFKSIDDRFDETMERLEQEVGERMNQLEEDVKDCTVEIVESSLKRKLTNASLRVDGSVFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK32</accession>
    <name>A0A2T4CK32_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1418471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK32"/>
    <dbReference type="STRING" id="983965.A0A2T4CK32"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="88" mass="10161" checksum="71D2B031BDCFFE89" modified="2018-07-18" version="1">MRDAGNSWAEIAKTFPTRTEGSVKKHWYKDMHYAEFAEDESQALLNAIKEYENNKWKVIGQKVGKPAKACEQYAKEHFPDLFGNPKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK56</accession>
    <name>A0A2T4CK56_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1435625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK56"/>
    <dbReference type="STRING" id="983965.A0A2T4CK56"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="79"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="304" mass="34787" checksum="AEB2599E3DA223A4" modified="2018-07-18" version="1">MSSTRTTKPEPMTTDNAALRAYYESWDSRIVYQIIMGGTQHFGYWDQDTYWPFPLGSKLRRMEQKLMEILALPKGSYVLDAGCGVGHVARYMAQHGMRVLGIDIIDWAIEDARRAAKDAGLPKESMSVEKMDYHYLDSLAGESFDGVYTMQAFGHAVDPQRAMAGFSRVIRPGGRIAMVEVERKTAAEHDDPNDRLTQELKMVNDYTVMPTNEAASEDYFKRLLEEAGFVDVEVRDWQPNILPILRLFYSLVMIPYLFFRLFGNEKSFINMICARSGYAGRSRWRFVAITATKPGERREKPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK78</accession>
    <name>A0A2T4CK78_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_358054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK78"/>
    <dbReference type="STRING" id="983965.A0A2T4CK78"/>
    <dbReference type="OrthoDB" id="4895738at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31285" checksum="F7E0F2A2DCC44839" modified="2018-07-18" version="1">MKRAVGPLDKRRKVTRCEACARRRIKCQGGFPCEYCNRRKKICAPQNASLPHPADFSAKFVEYTPPDQRLAGAARLPPQVQSHNNDLYRSSFASSLSRCQFSKNFVDIARDLMPLMQTSPPLRDLAIAIGALDAARRVYVRSSPERESPQLVAYRSYGRSLQSLQQRLKTPEAAACDDVAWISFLLGLFEVRCRRPSTTPGMQLTASQLMSESSGDAWVNYMFSGTSKVLQLAGPDACSSPLQQRLFSVFRVLEANRAILYGDATFLSEKKWRLHLNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP20</accession>
    <name>A0A2T4BP20_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_23556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679209">
        <property type="protein sequence ID" value="PTB71052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP20"/>
    <dbReference type="STRING" id="983965.A0A2T4BP20"/>
    <dbReference type="OrthoDB" id="5083270at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="207" mass="21701" checksum="D880970AB800075E" modified="2018-07-18" version="1">MASLAEQPFSLFSQQQDEYTHFAEPPHVSVYSSAPMDLSIPADAYGSYVQRAPSQELYTSPSTISYEPSLYPAEAAFMNGPTSPGYGDEYLPSSSLSSASAQSAPSSAVGSPLSNHGQIGMATDCYLSGLGIQPGIANAEFVDFAFGAHGLDEMTAFEFAHMAHTKSFVGGSLRAGGISRLGGQWLSCPAAAMATPARLPLEWLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPE7</accession>
    <name>A0A2T4BPE7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1442893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPE7"/>
    <dbReference type="STRING" id="983965.A0A2T4BPE7"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18205" checksum="47CB685FE90BA23C" modified="2018-07-18" version="1">MESVESRIIFVLGAGKGSLCKKLAKNYGFTHLSIGDLLRNVVASPEADETVVGFVKHGELLPTELLFDVLGPHVSGGGTIILDGFPRRLDQAEAFEKVFQAPTLVLFFDCPRHLAEGRVINRKQGREGDNLETFKKRYNEFQKLNPPLLERFEKQGKLITVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPQ1</accession>
    <name>A0A2T4BPQ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPQ1"/>
    <dbReference type="STRING" id="983965.A0A2T4BPQ1"/>
    <dbReference type="OrthoDB" id="5689at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050276">
        <property type="entry name" value="MshD_Acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617:SF9">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="182" mass="20806" checksum="A7FBFA5762CFB508" modified="2018-07-18" version="1">MAGHNLQFRLATPEDAGQLQQLVQSAFRAEDSRPDWTGNAELASSFQIGVEEVLPKILNPDNVVLMALDETNNLVASIEVAKRDNNTGRLSMIAVDQRFQQNGVGRLLLAYAEDYCRRTWNAERFSLNALSTRKALIEWYIRRGYRKTGETTAFPLERFRNLDLPDDMCFIEMEKDFGKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQG9</accession>
    <name>A0A2T4BQG9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BAH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1442645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQG9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQG9"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000015">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit RSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000048">
        <property type="entry name" value="RSC complex subunit (RSC1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="262"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="374"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="869" mass="98756" checksum="B43A4EC123EEF291" modified="2018-07-18" version="1">MDQERPKDATDGDVEMKENVDENNVDAGDNADQDEPHDLYQTISDLSKYLCSVEENGEELAAGFQRIPNRRLLPDYFDIISEPVAFSTIRGKIQKKQYTAFSEFVKDVAQICHNAQVYNRPSAPIFGAAERLREIFQEELKKLVDSGEITAEDARLPDLGELPPVEESPSQQSEEEDEQDERMKGTGDGDDEEEEEDSDENSDDEDYKGRNGRRYASDRGSRTNGKDAKFQQKRGRPPMVLTPTEARIFSVLKELRKFKDADGNPLASPFERLPDKAIVPDYYQTISNPIALDNIKKKAKRKKYQSVDQALSDLELMFENAKLYNEDGSPVYEAAVKLQQQARVLAEQEKLKPDDEFRDEDGKLPLASIEYNGETWKVGDWVHIRNPNDLAKPIVAQIFRTWQDREGQKWINACWYYRPEQTVHRFEKHFYEREVVKTGQYRDHPIADVIDRCFVMFVTRFNKGRPRGLAPDKEVYVCESRYNEEKFYFNKIKTWASCLPDEVRDKDYEMDLFDVPRPMKKIPSPIKHLLRDDAKETDELPRPTWGSPNAPPIIGAVHRRPPGPNESPPPADAMMPAMPAHPKIPPEPMQRLPMNPGVKDATSEAARHGAMPYAMVGAVPPPGQYYGHHHTPHFQPVPPNAAPPIPQTPVPIPHPPQQTPPPHMSMRPLQYQQYQPPQPAYMQNYNPGYAPSPALPMHHQPAPVPRPTGYMQGHNAAVPRPPGLGTPNMPQAHGNLYNPPRPPEVYTLPDNLNETLPAAVRQAFQHDEAGRVLFFAAAPLDRSCKGLSPLSSGLGHSARYLAGRGKWLAERERKRKERDEQLTVLRQKVRRTEQQPDESPVVSQAARALELFFQNLSQDSERLKKDVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQT9</accession>
    <name>A0A2T4BQT9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1364944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQT9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQT9"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="650" mass="73125" checksum="18F1DFE864FD2D91" modified="2018-07-18" version="1">MANRLNPRGALPTRPAVPQRNDTSLPPHESEAITSIPVTPGISQGTYGLERPNGFPSSRRPQQERQDYFPRRPAHPVPAQPPAASPYLNEITLAARQGDVALSGNVLSVTFTLPQLLRFRRGGKWELEHKYHCSTHLDSLSYLSSPESPWQHTVIAWTGEIYNVSDNESASASQEKLQESVPASTTTSLGGHAPADDEVGSGETFISRTSKAALEEKLYNDQIRTLPVWLADESDITDAGIKLKSQSRWRRYAEHDLCALFHYKQRAPTDGHQAIVRWNDYRRMNEAFADRVCEAYKPGDIVVVHDHYLMLVPELLRKRHPDMHIVFFLESPFPTSELIRCLHRREEILKGVLASDLVCFQAFHYLQHFANSCSRILRYKATSEWVETDETKARVHLTVLPSGINVAKITSLAYAPSVDKTYAELQKLYRGKKVIIGSDPLSRFGGVEKKLQGFKRFLDKYPEWRHHVVLVQITSPATMGDDDGDNIVYARQVNDLASSINQAYGSLDFTPVQIHNQRLSQDEYFAVLRLGDVAVNTCVREGMSTTSLEYVACQRDTHGPLIISEFSGTASFLEEAIRINPWDVSQVADEIHHALTMSPKERNQMHKALYQRVVQGNVQLCVSSMLKGLIDVLKLGDSGSYRNKENLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRD4</accession>
    <name>A0A2T4BRD4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1406133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRD4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="8819" checksum="CF520AC1CD0FC639" modified="2018-07-18" version="1">MITAVCPQSAGLVLRQPGGGLRDACQRQCLFLCSYIDAAPSQFVPPYDSTSIYGRRLNPRVAILDLLKQVRTQSVSAWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRT0</accession>
    <name>A0A2T4BRT0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_366897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB72017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRT0"/>
    <dbReference type="STRING" id="983965.A0A2T4BRT0"/>
    <dbReference type="OrthoDB" id="4174342at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="525" mass="56763" checksum="E92F696FD79DECCE" modified="2018-07-18" version="1">MMSPDAVSLLFPGRPIRPLPKRRLRERLPPEVANSIKYPSYIHDHIPLFYYPSYATRDENGTSAATSVGATMPHHRDDSKRNSTLRRHGASLTAGISEEVRGSLVLGSSSRIQGMVIQSSVVLDPIRQTMEFQLVPSAASSVDGYESFENTNNKKKRKIPTTGDSLANNGLSLSSDVAALATAVRSQSPAKETDSNRGQLVPPSPAGNGCYVPSSQGLSGPGRGRLGRSRNGRSPLRALSDGSNAWSSRSKATGQTGGGIISNAIATAGKGTLQGQENGSLLQQHVATERELPTASQFTFTCESQTPGAIQWPGRSVGQSTSSQALQHLPAGATSGPGQQEGNSSKQVSRLPASSARKSRRRLERELAAAARTRRQIATENYYHDLVNPADIWICEFCEYERIFGEPPRTLIRDYEIKERRQRQEEADRKRLLEKAKAKSRKGKKASKAGAKGGLPSDHTSDQSHAAARPADTSPVLANGRGRSTHSNDEYEDDYQEKNPDAPARHQPDIASTHADPLPPPRAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRU9</accession>
    <name>A0A2T4BRU9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRU9"/>
    <dbReference type="OrthoDB" id="5213490at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="85915" checksum="9DEF3A7483382FA9" modified="2018-07-18" version="1">MEQATCGTGDKVQCLPDRGCGLLGTCMRSVMRAASCGFVLVRGRPCPLHGRHFLDFSSAPSGPRCAPDLDAPHCPSRTMHDVLPSYPEAIARPDWLQLAAPYVAITDYPALCRVNSRCWHIFAPLLWRDPCAWSKRLGRSTDDNTGRFWSRFLLRDARLLSPRTRDLIRVVDIRKAIAHFYQLLALLPNVESLLIDDFCRVNARCLDHADPSRPDRRLLMLSLENNSHGISPSLTESRHLRALVYLDISDAQWLPELRILKMRRKQLNDYRWEAWAQLLRWRLWSLDISDNELTDASVRNLTALMDGMLERWHQCGAHDQYILRPSYLIDAPPINNADGAHDRDVTPTHVRADGSTPVRPDTLNGVLDLLSRPGVSGITHLHISGNRLTADGIRELLVMLFFPTKRRTTRTYPPSLKAPKLHVSSAVRMSGLPGLGHLFRPVYSSNLRVLRIHHSLVTNIPTLTMDGLRSVECAYLAENGVFPGLEEAYPLPFLPEMNPRLQSLTLTCVPRYSFGPLIRRLAFFFRCLSLQAEALSTLAKNADAEAGRSLRLMAEEPLDIDAEELMASGGASFSFFDSPLTETSNIKPKQPRTIDLWRQMPDPPEAPPGHNPMSPDQPSSSDPERQVWVLYANVNPNMSGDTHISHSVVWAGNGWSTNPVVQGIGPATMHQTRAGAPVGCLLFHTTWRFAAMPQTLNLPPDVDSQEKVDVAAELRQRWCRTQEDYQRAMQRFPHRQYFTWDGKLEIVDPEPVDHGWLLSMDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSE7</accession>
    <name>A0A2T4BSE7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1405932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSE7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="14051" checksum="04F51E958E3C7164" modified="2018-07-18" version="1">MREIWSIGHKHAQKPPCTLNQLRRVLTESTQIPRHTKLPYATRQPQVFLLAIRGFVVIEAVGRGTSSFAGLPRDEGVPATFYTPGICLLSFKVCPSNYIREPWGLKTQPNKVPGLATRVVSTVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT03</accession>
    <name>A0A2T4BT03_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_22394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT03"/>
    <dbReference type="STRING" id="983965.A0A2T4BT03"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="52"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="220" mass="23868" checksum="1BD3ED996580BE14" modified="2018-07-18" version="1">MLHLEAIDSRTTSLQESKPSPSQTSWHTSSPIAPTADPTSPAALSEQIRSIMRLLPHSVVVCTSTHDQAPRAMTMSSFTSLTLSPTPLISFNIATPSRTLDAITQSGHFNIHIMSGDELGVQVADRFTRGNTDDVFEGLDYDASGTDAGTPPLLRGEGVMYALRCRLLRDEPTGGVMRVRDHVIVVGEVVEMIPGSCGKEFGLAYADRKYRQVGRVIARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT05</accession>
    <name>A0A2T4BT05_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1448456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT05"/>
    <dbReference type="STRING" id="983965.A0A2T4BT05"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="88"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="491"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="533"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="577"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="627"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="750" mass="81948" checksum="5C159C93C3EE9BA5" modified="2018-07-18" version="1">MSNQAPAQGAGAAGSYAGQPATSPAGPPAAATTATTATGGAMSNQNLNQIVTDYLLKRGFNRTEEVFRQESKHLGSDGKPVQQLAILGPKKYARAFRLLKDWVENNLEIYKFELSKLLWPVFVYSFIELVGNGYTEEGKSFLKEIGQHFQATHADDLKTFSLITLPQHVNENSVTKLYKENKYRIPLNQHATGDLFNFLERESDQGGSVIRQLLVTYCQIDSTARGPITPYSFEAVFRRSKNLDLEEVDAKEGIPGVNIGLSNKDILDPAAPLTLGPLPMDPDLRDDIRAEIEDEERRNPPSGPSLIEELDQKIKREESADAPSRSDLPLPPSRPRDIMLEMQKLRENRDRFKIEGRTGGVGVPVSACMFTFHNTLGSVSCLEFSDDGQLAAVGTTESYIRVWSLDGSALPSSNAHEKGAKFNSRKLIGHFGPVYDISFSDSASGPPQKLFGDEGRQNPAIDGRPKLLLSCSADGQIRLWSLESWTCLCVYKSHDGPVYRAQWSPHGHYFLSGGYDKVVRVWMQDHASPQRLLVGHDTSISAIAWHPNGMYVFSASDETDKTVRMWSVVTGACVRVFTGHSDHISALRCAPNGKILASADIAGNIFFWDLIKGTRIKRSRGHGKGGIWSLSFSVESNILASGGQDGTVRLWDVESPADPHKAAQQNGLEAAAAGTELAVSGANGEASRLNTASGQPTTTGTTTGTKKKSKEVMITPDQISCFPTKKTPVINVKFTRMNLVMAGGCYDPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTG8</accession>
    <name>A0A2T4BTG8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1405026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTG8"/>
    <dbReference type="STRING" id="983965.A0A2T4BTG8"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031221">
        <property type="term" value="P:arabinan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23399">
        <property type="entry name" value="beta-trefoil_ABD_ABFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000131">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000059">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032317677" description="non-reducing end alpha-L-arabinofuranosidase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="12">
        <location>
            <begin position="27"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="11">
        <location>
            <begin position="358"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB72594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="504" mass="51571" checksum="B848FB1C36848B5D" modified="2018-07-18" version="1">MAMLSTAGIIAGALGFIATASLVAAGPCDIYSTGGTPCVAAHSTTRALFNAYTGPLYQVKRGSDGATTTISPLSSGVANAAAQDAFCAGTTCLITIIYDQSGRGNHLTQAPPGGFNGPESNGYDNLASAIGAPVTLNGQKAYGVFVSPGTGYRNNAARGTAAGDAAEGMYAVLDGTHYNGACCFDYGNAETSSRDTGNGHMEAIYFGDSTVWGTGSGKGPWIMADLENGLFSGSSAGNNAGDPSISYRFVTAAIKGEPNQWAIRGGNSASGTLSTFYSGARPQVSGYNPMSKEGAIILGIGGDNSNGAQGTFYEGVMTSGYPSDTTENSVQANIVAARYAVAPLTSGPALTVGSSISLRATTACCTTRYIAHSGSTVNTQVVSSSSATALKQQASWTVRAGLGNSACFSFESRDTSGSYIRHSNFGLVLNANDGSKLFAEDATFCTQAGINGQGSSIRSWSYPTRYFRHYNNTLYIASNGGVHTFDATAAFNDDVSFVISAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTN2</accession>
    <name>A0A2T4BTN2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1079541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTN2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="9575" checksum="157E067876563071" modified="2018-07-18" version="1">MCLTDGRPTLRPRKRPSFYKQRRLPFETIFLLHPSLAFYFPSSLFLFVRLCRLPTYYLIQLLWTFSVHISIAAMTDATRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTR2</accession>
    <name>A0A2T4BTR2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_7747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTR2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="58920" checksum="17B21A9A3091927A" modified="2018-07-18" version="1">MVKKAVYLYGIAPCTGGLAFGYDTGSMSGILAMPQFLTYFKNPSNFLQGGITASILAGAFAGSLLTGAFLADRLGRKRTILLGSAIFTIGCAISAAANNVEALVAGRVINGLGNGCLTMTVTMYQSEIAPREIRGRIISVFQCFVNFGILIAFWIQYGTSHINSSASWRLPMGLQMIATVALHVTMWFMPESPRWLVQKDRQEEALQVLAQVHAGGDVNDPYVQAELAEIVAKLSFEKSHPPPSYFDLLLGSQRRRMWIGIGVQFWQSMTGINVIMYYAVFLFQQAGLGATSSSLLANGLQGVVLNLFTYPNMYYMDKWGRRLPMVIGGVGMGISMMIIGVLMKAYGDPVYDTLTQKTNFDFTNAAASRTVIAFVYIYVAVFAITWACVAWVYPPEIFSMSMRGRATSMTTATNWFINFWFALYIPTAMAKISWKLYMIFMALCYLMSIVVYLFYPESAGKTLEEMDFLFSKGRSPWTFLDREATKIGALFQRDLEHGEALTVFDEDSMALKDKVRQVEDVVEAGAHGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU78</accession>
    <name>A0A2T4BU78_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU78"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="71" mass="8119" checksum="25F23C6DCD77F17D" modified="2018-07-18" version="1">MSSTSIKPGESRKEGKKKKNKETKSKNGRDQYIVSAPLRGAKREHMIQEKKEKGKKDGLPLWRLLNPWSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUC5</accession>
    <name>A0A2T4BUC5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">EBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_60032</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUC5"/>
    <dbReference type="STRING" id="983965.A0A2T4BUC5"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="16">
        <location>
            <begin position="75"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB72907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="260" mass="29812" checksum="54357C094BE173A7" modified="2018-07-18" version="1">MSQWGLFNYKRQPIKADHPYYPLGVSLPDYVPNGLPLSRSLPLFGTLVGAVVASAFWFSGRRRGASSSRRGVRSVDRFAASWFALCGFLHIAFEGYYLLHRTNISSMNTLFAQLWKEYALSDSRYLTSDVFTVCVETITVFAWGPLSLLTLYCIFTSHPSRHLFQTVVCVAHLYGVALYYGTNWADQRLHNVSYSRPEALYFWVYYVGFNAPWVIVPFVLLADSYKQVVKAFRALQEKETKPETKPVRAVQEKESRQRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUS6</accession>
    <name>A0A2T4BUS6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1433257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUS6"/>
    <dbReference type="STRING" id="983965.A0A2T4BUS6"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="456"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="71727" checksum="D2D8CACCD6D61516" modified="2018-07-18" version="1">MDTKDFDVVRIARSDGVDTGPGYWPVVTPTPAAANATKKAGKEATAADKAPRTKPQMTRLAEDDPRFVEWRIKLGILLKQELSPTPDEGNPWYVHFPRGYWLYEKSKHLWVSGYPIKSKLFKSPQEFGVHLIWLLSASTDYGDCCCVHCNTPASSKPLVAPEEPTGQTISHSSAPISIPASAQASTQPLGDAAARTEQPERPFKVTPVPLPTIPGQPAQRPPSITPRPQPVQPQQSQQPQPQQLTQQQIQQSPVPLPAHLQSREPAQTAQSPQLIQPNPSQPIPTAGTNPPTPVPAAVATTAPMPQQQQQPKAQAIQWSLKSPLLFRAGELVWYQTGNTWRLGIISNPGNMTPNGMTFELLPIGHAVVPQPNVTKLETDLRPFHCYSVPSVDIAELKDKVFDEVPWESLFQAAGNNAVRRDLINLDASKMAASKVDFSHSLWTRRGDDPTGKAVSYYGCFFGAERLEIGDAVRVKMAGAEANSSQTTVMGLLHIFTSADYPGSVFFRGPIYQLSKQGPSAAAAAAAAGGAVIDDEKEKLPLALQEEVRWRTQVTRGRQWCWVLIKDNVVFKEQSIRGRFYPTHRLMPIYNPNEFGALVAGQQPLRDQHIYLNNRMDGAGGRHIGRKANRLDTLGPCVPHTARLMLEPHIQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV47</accession>
    <name>A0A2T4BV47_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_143690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV47"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16403" checksum="B3D8177947AD5A11" modified="2018-07-18" version="1">MMDAESRRWSGHVYMTSDKAVVQLNCRSPSSSRFVAAVVSLSFRVVSCIVVPCVDEKRVAGERNRNQTSGREREGKIWAGWMCDRGDSKRRPRPRPRTQTRAACLALPCLALPCLAPTCFWSWPDPALALAPCWSHSAALFFCFPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVL9</accession>
    <name>A0A2T4BVL9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1382351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVL9"/>
    <dbReference type="STRING" id="983965.A0A2T4BVL9"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="211" mass="23467" checksum="83A6F39B5D0A3609" modified="2018-07-18" version="1">MSFSVRTAIRPVAAAPFRCLVAASRARCAFTTSSSLRSSDDAGATAGELGVGELQGATFKIEPLRRVGEDDATKRARLLYQSRKRGTLESDLLLSTFAAQHLPTMTTAELDQYDLFLDENDWDIYYWATQREPNSSTNPSGFAARRADEALPKDPPKGEWAQTVGNFRPAYRPVPQRWRDSEILERLREHVRRRSVGGEGTGMGFMPPLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVM8</accession>
    <name>A0A2T4BVM8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1361339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVM8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVM8"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="499" mass="55072" checksum="882459D2D320FF11" modified="2018-07-18" version="1" fragment="single">MTSPWFSPRSTTGGSGGAGGNSRPANTSPDCALSNQDFSTPSTGWQLDDFVLDPGYVASREELRWLLLNTAQTAPSSPAHGDSFVSGPDSQGGEDLSSAQHETSHLLSQGRRIEYLKNYISQVAPWLDMFDSSRAFGMQVPLLAQTSPALLCAILAISARQMERKEASNGTSTSQKSFDSLELYQESIRLLTPLLEAHDQAVIPICVILCCLEMMSASARDWRRHLEGCAALFDAFQVHGFCGGLLQAVFWCHARMDLCGALISDGTQSTIIPPLAWLPPGTDESNARQYFQKMQDPDLHANYAVYLCAKACELISDRTHHDELGVSNGCTAEVFSSRWTRLWDDLQAWIDDRPYELLPLQTVESRPFPQILYLHWAAISSNQLYHTACILLLSSMPRGQNPIPGAAGSSIWHAKRTCGISLTNPHHGCLNNAIQPLWLAGRLLTHEAEHSILVDLIRDIESTTGWGTCWRIPDLGAAWGYSVRRRNRSEHAHVDKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVW8</accession>
    <name>A0A2T4BVW8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1433014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVW8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVW8"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="18435" checksum="6214202C18511E4E" modified="2018-07-18" version="1">MPSIADTPIPGNPFYDARSPASNFPWSTVFLAGQACDGPLPASAPREHQVIVMLRGGCSFSRKLDNIPSFSPHDRALQLVVVLDEPPPASQNSDGDEDDAAVDSRGDLPRPLLDTEQTTPKGMKRLHGIPMVLVRAARGDYELFGSAVGVGMRRKYRVESQGLVVENAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW45</accession>
    <name>A0A2T4BW45_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1361618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW45"/>
    <dbReference type="STRING" id="983965.A0A2T4BW45"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="333" mass="36955" checksum="1215E16B672F1023" modified="2018-07-18" version="1">MLPLSVRRAVASAPQGAGLTSLATSVPKVAASSFILNRPQRRLSSSKPSRSDEPNDIAAGQSVPASASARGESKAGRKRKTKDAADRNAAFKKLPSVPSTHHMSEEALGLSTFFSLHRPISVTQTMPRTVTDEHFASIFATRSKSSRIRDTVSTLSDTIDQLEGPMAQMTIGGQDQGASDGMHRLDVKNSDGSESSIYLQVDAMSGEFLPFRPPPLPQPQQGVEADGVAAEAEALEEAAHHRVYKAMFTIEESTEPDGQIRIIAHSPRIMQDKQPRNFLERLALRQLRFDQTRGHRDMYAISVKRQRKLKMKKKKYKKLMKRTRNLRRKLDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXA3</accession>
    <name>A0A2T4BXA3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1361002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXA3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXA3"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015374975" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="203"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="435" mass="48121" checksum="65D491EEA6BA5E88" modified="2018-07-18" version="1">MLKSIYTSSLLLLSASLFSGSTASQEAQVHLTAPAKHHQVDPAILAALEKHSDPVDAFVSLHPEAAEKLAQPRLLHVFGEPSAQWMTEGDKLRLKRQGKKFVDITEHEDFYKEQVHALAGEAHLPKLSHQRLVKSLLPRVSTEKMHDVLEHMTGYYTRYFGSVTGEESSQWLYNHIAEIIKNAPFHTHISLEFFTHSFPQSSIIARFEPKVRNFSLPLTILGAHQDSMNYLFPLLPAPGADDDCSGTVSILEAFRVLAESGFIPSNGPVEFHWYAAEEGGLLGSQAIARYKKESGARIGAMMEFDMTAFVAKNATESIGFIETEADAPLTSWAADLAKEYISIPANVYTLPSGAGSDYMSYTQLGYPAAFASEGNPSAGEAEAGYGEYDPYVHTEKDTMHIDDETGVFSLEHMARFSELAIAYVIEQAGWDNKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXG7</accession>
    <name>A0A2T4BXG7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1432804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXG7"/>
    <dbReference type="OrthoDB" id="3433125at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="538" mass="58378" checksum="D42033F91D1AC169" modified="2018-07-18" version="1">MSGPDSHNRYLQPESSAGGGYGSHYEEDGNTSSHSRSHSQSSTGGRRRKGIVSGLVRGVAAGIGLASESYHNHQEKKKAQAAAAADGARPGNSSEGNRDERHHVSRGREGDQSSSSDNDEPVRVDQETSRQLEEAAWQLDAAQSQLEPPPDYATVMEQDLDVQAMAEGFVQSHALASTQQVQRHGLPMPVILPQRRPGERARGFIHAYAPLLQDVGIEEATFNDFITQLNMATAPSPWINAINLAAVAVQNVPEPVTIAVSIAAQVGTQVSLQAHSRSKTNTFLNKMNAEFFRPLGLIAVILTWKPSRAGEVVTQATFDAAMEQATQRALGPAGSGAASGFNNKMQASHGTTSFEWPESAPLVFPTLDKLASTPGGRQMVEDAGKKPNAMKRSMNFAMEYMDKRSQAQWANEHPESRLAQLNEKPEFHSRYADPNHPASSGSLLALLTGGAVTGRLSQRGQARRDERAARREHRSGRREAKREQRGPTLLSTAGPRALIRGIKKFMHEDVLYLMIANLPSTEDMAAAQQFLRAHPVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXS9</accession>
    <name>A0A2T4BXS9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1339237</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXS9"/>
    <dbReference type="STRING" id="983965.A0A2T4BXS9"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB74072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="97" mass="11212" checksum="52F89167D4EAE19B" modified="2018-07-18" version="1">MKVTIKEWNSVATWQWDIPEDDVCGICQVHFDGTCPTCKYPGDDCSLLSGKCGHNFHMHCIMEWIKQESAKGQCPMCRQPFEWQDQDKENEAPTQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYE4</accession>
    <name>A0A2T4BYE4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1381015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BYE4"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1665" mass="186940" checksum="8A4D8F900A0442F6" modified="2018-07-18" version="1">MAEITTLDALQALHRELLTLSSGGGSDSDNLSNDLLFEIFEKELAAIWDRPKKSDKSRATVKTGKVSVDGSQYSLNDKFQQDVFALSDEIDLDEVEAVRYLLDSQDDVSVMGRSLLECAVIRFHQQRKYVLDSFRLFLELNNMDYDGEEPSALETIKAYVDTRLLRKTSSDASKRLAPRCLHAMGEIKTWLQRLGEKLTAAQTLGTVPTDELPEELETVEFSRVSLVQQHEALGVILCECVDKGQAETADFLEFISVLKKWDKYDTLLVHLVPAIGAYMSVFASSEGGYDLRQGRELNSKIFPPADDSTWPLPFLHATVRAWWLAEYSGWYLDDPPESAIPPGTDLDREDRQRSKQFIDSLKDGAFDFMLSVAGDVRSPDWHDSVRAGMRKWLQRKSSPLVSERTQFSSFFQLCLMSQFEVFVDAFITNLPDVLRKLRVEEDEQRQLSQTHEQDLDLERFLLIIAYAYEGRPDAAANFWQDPDSNLAGFMHWASRRASTPLVAAFCEMLQAISVNDECATAAHEFLLDEGHHSSGKMRRTQSLTWTQIFKELDFFSDKIRQKPTQTQSVRFRGGKLSADVIETEPESSMMLECYLRLITKLASESETTRHFLLLNSGYNLVDMLFELASSPIPSQLRGCVFLALRALISRKSLQENHAMWRCLENWISGGYVGAATGTIRAPQPAPLVSMDRIFDEMSNGFEDPESFIKLLLELVTPASDASPLNDGLPFPENLGASSRAPGIEVYVDFVIGLVFSSKIQELQDVHQTRVLRLSCLEFILACLTTFNEDLLVLANETNIAIDSLVSTTDLATYVRMHPFARVMEWMFNDRVMSALFNTIHQKSIDIGNATPDSPLILGVLRAVEVISKVLDLETTYLDLVRPLIKSQAGPRRHPVANAAYASFQDGLVTRLNLVVDLGKYCGVGHPDLTLACLKLLEKMASSSKITAAWSGTNRHAHRNKAIVAMEANGEHEGISRAFIAEVMTPLEAASGADSPLYTTKVYILDFLYQCLRTTPKEPTIAHLLLGFKCGLDSLSVEVNSAFASRTSLFHTILGLLLESPSSDAVGVRLWLIGIKSRVMRILHILWSSPLSSAIVVRELRENELLFHLLTRETVIHPDLSWEGQNVGNAQFPMTDGAVTLIDFLTLRSMTLEYIAMELCKIAQGRMPGVKRRIFDALNGQIVIEGNETIRTPTVFDLFDFLLPDGFWEIPPPSIQFYKDLDLSACLEEDDDGNRVYSLDRVREILLLKRGEAQQSAVIAANDMALIEREEVMILEYLLACDRQKQISSQCLRVLRSWIKVLLVMVESCDYRGAAQTSFFLQALQAILPSLELFASDRPDEALELAKLARVLLFKMDLSPLPTEDKNSSAIGNLVSDKLYQLFQICLQAIGKWAGSPELRAVYYEICYRYLTGMSEKQGPLTASRPKAFKTVQVYGERLLNVVCDDAYCGEPACQTAALIFLGALVHMDSQERESYIVETLNKLNFIGILIDSLRNIMKEWHDVFASNNTDQKNFQNARLAIILQLAQSRIGAKYILHANLFRTLEHSGLFDADPELQTNPANARALEQHYDLLARVVRIIGAAILSRGNNNVAQGRKFLTDHRMLVTHALKRSAGIGAGKEDQRLEERIEELADALVVVIAATSFLDFENDILPEPKQHDQPLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYT0</accession>
    <name>A0A2T4BYT0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_57558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYT0"/>
    <dbReference type="STRING" id="983965.A0A2T4BYT0"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="332"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="420"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="456" mass="48156" checksum="3A124D721A67598B" modified="2018-07-18" version="1">MASIVNERILAAAPVTNRGQGTQLSADSKGKRIAYASGKSIFVRSIDDPSDCKEYTGHTHPTTIARFAPSGFKIASGDSAGILRIWEPESIETTRGEYPIISGPLLDIAWDGDSQRIIAVGNGRQNVRDHQVGVVIPHGRTDGLIISINLAGELTYLQEGKDEPVRVIQGHDKGITALTGGSDGSGATVVTGSFDGRVCSWDLETGDATVLDGQSHTNQIPQFATSSGKIYSVGWDDTIRTIDDAAKTFVGESAKLPSQPRGAASAGDIVYVAGISGVAAYSNGKLLKETPLDFTPDTIAAHGSYVAIGGQGNTARIYTSDSNGNLEYKESVSSPLGTVTALAFSKDGSHLAVGTSVGKILVFKVGTWELVTDRWSAHTARVTCISWEETGAYAASGSLDSHIFVWCLEKRLQGQRIKAPNAHLDGVTGITWIRGGRLASSGKDATVKLWEVNSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ22</accession>
    <name>A0A2T4BZ22_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MADS-box MEF2 type transcription factor MIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1423582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor acting downstream of the MPS1 MAP kinase (MAPK) cascade during conidiation and plant infection. Required for overcoming plant defense responses and the differentiation of secondary infectious hyphae in live plant cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAPK MPS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ22"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ22"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="617" mass="65719" checksum="C20BBFAD5969DF02" modified="2018-07-18" version="1">MGRRKIEIKAIADDRNRSVTFLKRKGGLFKKAHELSVLCSVDVAVFIFGNNKKLYEYSSKDMGQLITRYQYHGGPNEHKGPSDYNSGQNNDEDDEDGDGTPPRGPEGMEAHMVPAHYQGQPPQPFPQLRHQTASASPPVPNGVPFPGHPHLQRSLTPQPAGPSRPNSRGDMRRMGHGMMPQPVGPHGSHGPHPGITYMPTPPIYNPAASNQPGLMPPQPGPYPYQPAPQPYMEERRPSAPPAFRAHPPPQPLAVGPRTENPSPQPPHQLLPPQSMPPHTSPQPARRHLDPQPPPPVEPRTEAPEKPKAPLINTDTAIKKMSQRKSHSIFTPIEENRSILSQHLASFASEPQSIKNESGASAAANPNRAQSADNGSAAAAVRNGEPSPHLHQRSGLRNTSVSSLPDTPSQASSLKINTAVGGTRPKPPRLTVQIPDGASEAGSATGDSNSPRIPTDAASNAPHRHNSVVLPPPSPSATTLLSAGATGPPNPFARPVPQQNVNGDTPVSALPSRFLNNELLPSPSSFYPEWSFRGSDNNTLPSPLNFATPVVGTGPSFLRDDSHLLSSSGNAGSSAAGGNQGSTQPSGIAKRKSPDLEGPGQDENQETAGDSKRLKVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ75</accession>
    <name>A0A2T4BZ75_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1336798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ75"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ75"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF11">
        <property type="entry name" value="THIOL METHYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="282" mass="30720" checksum="6CD2A4AEFA8FBA30" modified="2018-07-18" version="1">MTDGPTRLRETFASTPVSAHNDAWDALYAESFHPWDRAGPSLALADLLAQRTDLIPPSVDRRNSSSSPSGAAFARRLALVPGCGLGHDVLLLSALGYDVVGLDYSPHALDLARENKAKADAEGRYAEYAKDGIGSGRVTWVSGDFFGTAWEKDAGASKFDLIFDYTFLCALQPSERPRWAKRMSQLLAPGGQLICLEFPSGKPLSLQGPPWGVWPEVYEALLEHPGEPIEYADDGSVKPGSVPRLPHPDGLHRVCLVKPRRTHKAGTNEDGSVRDFISVWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZD1</accession>
    <name>A0A2T4BZD1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1337007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        <location>
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        <location>
            <begin position="1"/>
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    </feature>
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</entry>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
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    </reference>
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        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EMBL" id="PTB74782.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="53" mass="5611" checksum="6D2C96F8E5AA18A6" modified="2018-07-18" version="1">MWAVATAQGSDPLICLRLRRLYVGGSAGQLHCALCIAASPTLFSFALLSHHGQ</sequence>
</entry>
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    <accession>A0A2T4BZU8</accession>
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            <fullName evidence="1">21 kDa subunit of NADH dehydrogenase</fullName>
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                <person name="Chenthamara K."/>
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                <person name="Grujic M."/>
                <person name="Henrissat B."/>
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                <person name="Salamov A."/>
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                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="PTB74776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="19845" checksum="B03C300DD523C24D" modified="2018-07-18" version="1">MASQTAAKVAGGVVSITKKQTLQSTGIWETIRKAFSLDPNRSNGVPLNPYFRNPAPGALDPQTYDDPVTLPAGDIADNPYWKRDVRRAYPKLSVVTQGDAVSLLTVGSAAQPKVELIGEAGDKALVAAQQEGESTGLAKFLEKAPKDVAKDVFVNGLPPLPSGQNLKAGGWDVHAYELNEEQTYGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C063</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C063"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="220" mass="24154" checksum="B0348ACD1F11CA43" modified="2018-07-18" version="1">MTTAVFLCAYGIGSGRGSPVESSLLFAYVVLCVYQIFTDYLPSDGTYSTEDQASSQPEIPPLPPIIMASYSTLLHILSTLPGALHSSLALLYAAFQTITPSVIISLAYRLFVFYCATRIIPSVRDLGARAMLHEPDWDESEAASMFLSLLSYFSPTILISVYTSLLLQHFSTSEGPDGWTLRGGDVGGSTWRWINVGLTMVLYGVELMLSTDDQDHWKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0F3</accession>
    <name>A0A2T4C0F3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0F3"/>
    <dbReference type="OrthoDB" id="4875899at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="196" mass="21423" checksum="6AD2FB25AFEC0F77" modified="2018-07-18" version="1">MEAPSPTSSAKALSPRSKIPVKASPMKPPVKIPIKRQPSSPRYTQIAYFNMSDSLSKPSPSSSPSRAAAPSLKSLDITRLPDDLKLIGPENWAPWSSAMTAVAELSGFDVAALGEMPRAVHVSCWHNADKTAEEVREGKMLGLLIKFNISAHMNDLVSLTMDGYEVWKVLKLYCARFVETDPSRVLKRNGGCIRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0H0</accession>
    <name>A0A2T4C0H0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1267633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0H0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="17020" checksum="3EFC4958238B4A11" modified="2018-07-18" version="1">MRWPPTSANPVSARVVVWPKKPGTWLDERPRALEQPCLFLVSKSSPSFLFFAPVRLPYHVVCSHFPPSASTTRGVRRRRPTRRQRKGTPANVGPRAARFPGKGRRCNSPIGAKRSNSREGEGRLHASFPSRSWEAYQQQGPRRDHADVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0H8</accession>
    <name>A0A2T4C0H8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1402644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0H8"/>
    <dbReference type="STRING" id="983965.A0A2T4C0H8"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="670" mass="72577" checksum="8CD57418A078EEB6" modified="2018-07-18" version="1">MAAIDHTAIDHSSEPSSLGAGSEPEIIEAYDEQVPTASHALAEESIRTGGEAASKGASQLEHDEVEVKNIGWNQKAQAVPHPVVGGLRNEELWTLIRRFNQQIFDVRSIDTVPLADLDMNVADDDAFSPGKLRATMERFYMTVVVSLVSLWKHIARLRSWREWKRTASFLGVYSVAWLLDLLVPTIIVFLMVLIVHPPARTFCFPPVPPAIVDSKTGGVQKPPAGVLANDTSITGAPEKHEGEGVEQEAHNFVNGIASVCTGVVIGTSAGKNPQDDPHDDNTAPDPTNLTDDISRAKDATDGTATDKAHDKTKKPVSTMVWAKTSPLMHMLSDFVDTWERFGNALSPTPPFPIERPRLTLAACLLPALLLSLFVSSYMLLKGIGFGVGFVLFGDPIITPAVQFVNRTYPRWEKFVELRNTILRGIPTNAQLAITLLRIGERNKTPIPPPPPAGGAPPPATIDPQAAQQVGSLGVSDHEAREALRPDLHHAQDGEAKDDAHQQRKPKRAQRILNVLKGTTKGGVQTALTADKAKATVGATNARNRLGAVDKKSSADHMSGPVCFPARYGGKKGHAFITATATTPALSWTSNLEDVNPAWTVAIEDIAQLKKVGGLGWKSKVVVGWAMDREVVDGLVVTTKDGKEYHLTAISMRDELFNRLVAMGHQMWEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0R4</accession>
    <name>A0A2T4C0R4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1358022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0R4"/>
    <dbReference type="STRING" id="983965.A0A2T4C0R4"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="254"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="685" mass="78423" checksum="3E36A4C1760C0691" modified="2018-07-18" version="1">MDHEREDGGWKPISNKMFYPSKDNLCDACRRISLPSLTAELASPPSFWREMELENAMPITSKYGMRLFDNALDFTKRAKSCAMCWLIAHAFAMQYQTLEGIVERPIFLSPWWTYGTATPMTSNPVEDQVPLMGMLVWIPIDSHPYATPRDGYVPCTLRFYTDDESPRTFQRIVGRVPVPYTGSPQILARLRHQLTTCRVNHTKCLQTVAGSPFDEKEEPTLPMRVIDLGPPSLGTEKDRELIRLFHTEGSRGHYVVFSYRSAVLENPLCTTRASLKDYLQGISWTKFPQTLQQAMELTKSLGFRYFWVDLLCVVQDDPEERLRESKRLGDVFEGAALVIADSSGWILEEGLFNTPSNQTFSSLVRIPYHDANGTADGTVLHVDCVDPNNISDPDETDSTFSGRAWVTQEYFMARRIAFFTTSGIVWSCRTVRIGPDGVQDNPTRNLENRKWFDIIQHHVLSELKHPEDRLQSLESIRTAIQKRDGGTPYRHGMFEKDLQEQLMWRVVKGRARKAENPVAVPSWSWASSMAEIQFFEYPANPAPLSIIIQWESCGNMSFKGDAISVPAAKMRKLKKSPWWQKMKVVPDPLTEPDDGNWENTLRFDEIEHPGKFAGSLFGLLLCTKEMKWPDDRLTLNEYFIVLRRISKWNQTYERVGAGMSSSHGRLMDNLLTWSSDCKVRSIRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Z7</accession>
    <name>A0A2T4C0Z7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1271437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Z7"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Z7"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="494" mass="56745" checksum="667994007981DA74" modified="2018-07-18" version="1">MSQNQGQTQKRCWNCRQQKIACDKTLPHCRNCLKKGRQCLGYGLKLSWPREGDRRRSASSRKEHYIIPIRSSEASFINTTSDDVRESQDQVLSRYDGTAFGEVWLTRRPQVNMARLDPYLASHDWSPVARLVSSSQSRDDLYGLLVRMSFQDETLPSLASRYAISALSYQHLAMDKAAVMHQTRAIRALQAAIETAAPSECMQLMAASMLLNIYETLNFDTSDLSWSIFFCGTKRIVNLVTKTDDTFFGDEALIIDWIFYHDVMYKFSIRHWREKNSDQILLASQRKVLSKAVFSPERQVIVPILGCSLELLDLLCQTIDAVYEPDDPNFQSESHLKQIRSLEIRLKYLQQRQSSLFPLDTTPQESTQETTVAELYRLATTIYLLRMAKREPDSAKSVLQAVDKAYETLNRLEHCERPWPLFVIALEARSEEHRGIMLRVLGKSVERRPLGAMALVARMVPDAWTQLDLREGGVDPFMLYGMIISRHRVPPCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1J3</accession>
    <name>A0A2T4C1J3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1J3"/>
    <dbReference type="STRING" id="983965.A0A2T4C1J3"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58634" checksum="BF1FBFC70A258C3D" modified="2018-07-18" version="1">MRGDDLLSRCICTITTTCSSITPTGSSDYSYRGTAFFFSRYVATDHGCYQNYDFIYDIWKPPSMRRSKGRGAAPLKRTDALISAGMTAVGLVGLSKITGDRETMVRAQQSYGAALQLANAALRNPGEAVEDSTMLGVLILGTYEFISGHTPQTLHAWQEHINGAATLATMRGQAQFQTKAGVRMFLMLCHSVLISCIQSGLPMPKSIVDLRNELRHVTDSKRPAWRVIDPLYRALQIRHDIKHRRITGVDEIVGSLVEIEDDFEKLINELPPSWRYQNVKLTRSNPAIMGRTCHVYPGLTQATAWNAVRTMRMLVQETILEQLCHSVDDPTTLPMHHQLLLVKAMRMLRMLGEAVVGSVPQHFGIVSSRDIKYSKTKGEQPTVTARNQSSTLLTAPLLPQPSESSIDESKSPVPAWPRESVATRPTLLDPTQSELGNGRGCDSERFLTLATASNTIIWPLYTLGLSSSCTHEMSAYIVDRLMTIYRETGLEQARVVAGMMQNKVETLTWASIPTTRLPSLPDDALPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1R4</accession>
    <name>A0A2T4C1R4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_324268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1R4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="68" mass="7491" checksum="4D8732868810C51C" modified="2018-07-18" version="1">MFPTVSSRAEKDCETQKQRQSLHDDAAKTWLKLEAGCGVAREEGRRKLTMHGKNGDDGGGEKSTTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1V1</accession>
    <name>A0A2T4C1V1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1334476</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1V1"/>
    <dbReference type="STRING" id="983965.A0A2T4C1V1"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="408"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="689" mass="76790" checksum="79FBFCD2243EC48C" modified="2018-07-18" version="1">MEMGSLPADEAPPDNDIMQLARIGDVAGMEKLFASGEYDATYSDDEGITPLHWAAINNQYAMCAFLIEHGAELNKKGGESVATPLQWAAQRCHYYTVNLLLQRGADPLITDSQGYNTLHISTFNGNVLLIVLLLHQGIPVDVLDSYGHTALMWAAYKGFPQLVDVFLRWGANVHATDEQGFTPLHWALVKGNAACVLKMIEYGADRFAKTDTGKTPALTASELNTTAAWHRALRECGYDEDGHVATPPWPGASYFLKDKKAFLTRFLFLWPFLMVWLVLVTLSGFPVYFGLPLAVGVAYGLLWVAKQVLEYAPSDMRAFHKTPWMAGIFAGSLLLVGVNWLFYILPATIGWQGSSSHLLLNLAFATAYGLTTFFYIASIRYDPGFVPKMNGIAEQRAVIDELLKSWKFDESNFCVVCMIRTPLRSKHCRRCQRCVAKHDHHCPWVYNCVGVNNHRQFFFYLISLTIGIPLYDWLLYYYYEQITPSASESCTLFGPNICRYINADSYTLLLAMWASLQLLWVSMLLFTQFIQVSRAMTTYENMTGIRANTSLSTAFTSTGAPLDPNHPSLAAPAAPAGGHAHGHKHKGGLLKQWSQLLGVDPFIETITGRGAATAKNKRKKKNPYSRGCVTNCKDFWCDPAPIFSQRESGYAMLGGDKVDYTAMYETPALMNITGMRRGGYEAVQTEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Y8</accession>
    <name>A0A2T4C1Y8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Y8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="16378" checksum="1EF75DE6B9BC121A" modified="2018-07-18" version="1">MGFRAQFVSICLKQENKRKHWLVVAVDRGSSRRGFVGEPAKEAELEAGANQRGKKERQRGRERVALEKMVEDGSRKRRREAQSESAVRRLLAVREGPVCRWTPSPSAVSSHRRCSARFGCAHRGSWIKLQSPQRSRRTDRQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Z8</accession>
    <name>A0A2T4C1Z8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1431298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Z8"/>
    <dbReference type="STRING" id="983965.A0A2T4C1Z8"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05323">
        <property type="entry name" value="ADH_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF10">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="286" mass="30303" checksum="C46AAB22520497DA" modified="2018-07-18" version="1">MAEISIKDEDLSGLKGKVVVLTGGSSGIGLATVDLLLSLGASVVSGDVNPPPSEAPGLLFVKTDVSKWEDLRALFKKAKEHHGRIDSVFANAGIGPRANYLALETDDQGELKEPSHELLDIGLRGLINTACLALHYMKEQPEGGSIVLMGSSTGLQPLRAVDYSAAKHGVLGFGRGLARLAEIAGLPIRINTLTPSWTTSNVLPGLEDLMKGISHVPQPALVVARAAAYLMVDASRQGNVVYIADGKYKEIEKTILYPAYETVLGQGNPSDDEVLKRLLEEAAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C209</accession>
    <name>A0A2T4C209_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0075-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1402122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C209"/>
    <dbReference type="STRING" id="983965.A0A2T4C209"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="439" mass="47915" checksum="BF0A20FDA99D6E53" modified="2018-07-18" version="1">MGSIVNPLVAGPALDLTVLGMNSGTSMDGVDCVLCRFRQQDPASPVSLELLKYGETPLDPDIKKRVMNMILHNSTSPEEIAEINVILGETFAKAALEFLKTNNIDQSSIDIIGSHGQTIWHIPHPKNQVRTTLSMGEGAIIAARTGITTVTDFRVSEVAVGRQGAPLVAFFDALLLHHPTKLRACQNIGGIANVCFIPPDIEGGLSDGFFDFDTGPGNVYIDAAVRYYTDGAREYDKDGEMGKRGTVDEELVDDFISSHPYFQRPIPKTTGREDFRDTLAFDLIAKAEKKGLSPDDVVATITRITAQSIVDHYKCFAPSQDIDEIFLCGGGAHNPNIVDFIQRNYPSTRIYMLDAAGIPAGAKEAITFAWQGMDAIVGRPVPVPDRVETRREQILGKVSPGENYRQLMYTAMQFGAGAKLGPVRDLVNIVDGEVMDNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C215</accession>
    <name>A0A2T4C215_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1402125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C215"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="542" mass="59782" checksum="6960A18F6CC687CE" modified="2018-07-18" version="1">MASTVEALRGQHDKTMTGTIETETAPEKEWGVITQGAKEATDLEHSQGILEAVRLQWKGVAWASFLSLSIVLYGYDNALINNFYGYPAFQKAYGVPHGDGYQIAAKWQTGLSQASIVGIILGATFNGFLSSRFGYKRVMLVGLVLMTGFVAIPFSARNVETLLVGEIFCGMTWGTFASIGPAYSSECLPISLRGFLTSGVNIMQIIGQLVAIGVLDGLVGLDSQWSYKIPFAIQWIWPVPLFIGCLFAPESPWYLVRKGRLQEAEHSLRRLSSKSDTKIKEHLAMIIHTVNYEEEVRTGSSYIDLFRGSNLRRTEICCLSFAGQVFNGLFMMNPGTYFWEQAGLSAKNSYKVSVAATAIGLLATCIGCVLIAHLGRRSLYLWGMVFMTIVNVLIGILATVHANEGTKWGQVALTILWVFCYDISVGPAAYATSSEVSAVSLRVQSVAAAKIAHQIFDIIAAVLEPYMINPTAWGWAGKTAYFWGGTSVLVTVWAFFRYPETSKRSYEELDILFERGIPARKFRKYDVDAYDVDGQQDQEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C271</accession>
    <name>A0A2T4C271_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1470638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C271"/>
    <dbReference type="OrthoDB" id="4899884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="279" mass="30556" checksum="55E9149EE443AB56" modified="2018-07-18" version="1">MARDQLHVFSRRSSRSSRHSSRPKKTCNAPDCHRERISKSHDGETKNSKFCHRHSCSLSPSLGLCCAEKRSSDVFCHEHSTCLVEGCKSRIDQSSSRRLCLQHNCRIQNCNDRVDAPSLNFCWEHDRAVFDSLWLPHILPVAVYATPSPSPSPPPSSSCRLSMGEELVDSVTSSAGSVVVSPASTAPSVKDEPRTHIQDGPVDAVTDVPVAAPVGQTLEVKTDIASPVIEGDKARWSEEEESLPAFFSGVGVGLCILLQIIYAIVQLLLELVRGSKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2N8</accession>
    <name>A0A2T4C2N8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_54428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2N8"/>
    <dbReference type="STRING" id="983965.A0A2T4C2N8"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="35"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="246" mass="27212" checksum="1EA7FDB269496CCA" modified="2018-07-18" version="1">MGVVLGASDDASQKKLDGYECAHPPYKTHLLSKSPLVIYIEGFITDEERLHLQKIAEGDFKHSAVLKGGNSAIHSVRTSKSTTVARDAVVRCIEARALAFQGFDTPESHLEPIQLVKYAVTERYHFHTDWFTDASHATASLGGNRVSSFFGYVKADNVTGGGTNFPVLDAPRDERWCRFVDCDEEYEAGVTFRPVEGNVVYWENLLPDGRGDQRTLHAGLPVVSGEKIGMNIWTRQMPLAADIRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2P0</accession>
    <name>A0A2T4C2P0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2P0"/>
    <dbReference type="STRING" id="983965.A0A2T4C2P0"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5672" evidence="1">
        <location>
            <begin position="131"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="40206" checksum="4D4869D22529DC43" modified="2018-07-18" version="1">MPTNTYRQYVKNRLLSCLWGRRRRYTILGIAILLLLPTLTHLITNTTTIALYIPRIRLEYPPAPPPPSPYNTSKVALLIENRPSPVLAPLMLHFITVVPPDWHFRFMGSPQSVASINRSVAIRHHVAAGKLQLTHIPDNMSTNGQEEISQFLTTLWLYEAVLRPAEWLLVFQTDSMLCANSRLNLNDFLEYDWVGAPWNPEGRWGGNGGLSLRRVSRIIDVLRNQRRVNGSQPEDVWLSERLAHHPGGKVANGSVSMTFAGEMHDGRAKQNSSNSGMDQADDEDYIPGVDDWRKGFYEPMGYHIGGSGSFLHSPVWGMPKLREHVWKYCPEVKMTLAMDVAKYVPGDCGARWTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C310</accession>
    <name>A0A2T4C310_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1265149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C310"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="190" mass="21109" checksum="DCF958245A110A55" modified="2018-07-18" version="1">MFKQRRMPRLDPISPWTPIAQRLLWPVKPKKQVDKSPPWLPFQTCKAAASSNCLPDRATACCLETRPFAGVHHLQGAWGGGIDDEITMSRILSGVVLRHELEKEKVLTAHAMSGSCRECLKIFPSWCFIQSRHASWSQQVGNDPSVQCPPFGQTYDGPNRISLTCLVLGNFVTCCRKWMPSDSCSGGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C341</accession>
    <name>A0A2T4C341_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1463547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C341"/>
    <dbReference type="STRING" id="983965.A0A2T4C341"/>
    <dbReference type="OrthoDB" id="5565730at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="22698" checksum="13E4C2DE7B5226F1" modified="2018-07-18" version="1">MGDRPEPSASAVQQQRKKRGILPPEIIDLMVAPVKVGTWTGAAGVMAGVAGAIARDTSPVASGAVTGFQWFALGGSFWFTRSVTVRAMGGDEQLRPVDKTIASTIGGSAAGAVAGLIRGPGKILPAMVMWGVLGAGGQLVANGMSNRKPKVKDENDSWFRSKWSPLKKLTDQEYIDMMEEKILRVDADIALIDDRIAELKSMEQKTKDENRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3J7</accession>
    <name>A0A2T4C3J7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3J7"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="181" mass="19400" checksum="FE4391C1B147B017" modified="2018-07-18" version="1">MKDSGPSAPRWALLSPAAAPPILTFNEPTMDFHVLSRIDSQNASDIQHPPPYSQLVQPDIRPRQPINAGEACSPEGQWNCMTTSWQRCASGSWSAVVPCAAGTMCQPFGLTDHITIEHTTSDSNNGEAHQEDNGHASDRRKGDEGECEKSGKKSSSGMRNSPGLCLLLETLLAGASWASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3P1</accession>
    <name>A0A2T4C3P1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenocysteine lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1430944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3P1"/>
    <dbReference type="STRING" id="983965.A0A2T4C3P1"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="22"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="407" mass="45262" checksum="24BB084137213B87" modified="2018-07-18" version="1">MAFEDHQREVRDKFPALQQDQVFFDNAGGSQTLGTVIDSIKDYLSSTNVQLGASYAVGKKSTSAYRAGYQAAARYINADPDEIVFGPSTTQLLRNLSYALKFNPGDEIVVSRIDHEANIAPWVDLAERQNLILKWWKPTAGPNPEYAPNPKLTVDTLTPLISEKTRLVTCTHASNILGTITDVRAIADVAHSVGALVCVDGVAYAPHRRPNVKGLGVDFYCFSWYKVYGPHVSMLYGSWSAQTQLRSLGHFFNPSASLEDKLGLAGGSYELVQSIPRVVEYLNGKWRSIISHEGHLQGELLRYLRARAGEFTIHGEPEEDTSLRVATVSFSVDGWDSQAVVETVEKKTNYAFRWGTFYSDRLVRETLGLGKNGVVRVSMVHYNTLEEVRGLIRALQDLWLTIMASEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3V0</accession>
    <name>A0A2T4C3V0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1333075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3V0"/>
    <dbReference type="STRING" id="983965.A0A2T4C3V0"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="172"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="354" mass="38978" checksum="231032CD9BC7EB78" modified="2018-07-18" version="1">MAREDDVETQSGPNENTSLLAGEHPEQSPQEERVNEKNLAHWVLWRIVWALVAALILVVFIKGWIDADGDVNFDLKDALRKALGGGLSGAAAMVLQVLLLMPLRTIMNYQYRFGTSFSQATQILYADGGLGRYYSGIGAALIQGPVARFGDTAANAGILALLQSNSYLKHLPSLAKTVFASLCAAGFRMILTPVDTLKTTLQAQGSHGTALLRKRIKEHGIGTLWWGAFATAGATFVGHYPWFATYNLLTEVIQEPPKSELFLWLLRLALIGFVASIISDSVSNSLRVIKTYRQVNDTKVSYGDAVRLVVRDDGVLGLLGRGLKTRILSNGLQGLLFSILWKLFLDMWVFHWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4R6</accession>
    <name>A0A2T4C4R6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1377759</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4R6"/>
    <dbReference type="STRING" id="983965.A0A2T4C4R6"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="451"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="711"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="833" mass="88334" checksum="FC80EE63C15528B5" modified="2018-07-18" version="1">MSAAEGATSTTGRSEGGSRGRGRGGGGGGGGGGRGNQGQNRGGAKRGGGRGGNARGQGRGQKGTEAAAATSAEEAAAANKENKALAATAPKLQADDDDEEDGDVCFICANPVAHHSIAPCNHKTCHICGLRMRALYKTKDCAHCRTPAAYVIFTDDADKKFQAYTDSDFTSTDSSIGIKYTNEEIVGDTVLLLRYNCPDGSCDFAGLGWADLHRHVKSAHRKRMCDLCTRNKKVFTHEHELFTDKELERHMRHGDDKPGAADQTGFKGHPLCGFCGERFYDDDKLFEHCRMKHERCFICDRRDSRQPHYFLNYDELEKHFKKDHYLCPDRGCLEKKFVVFESELDMQAHHLAEHAGKHVGRDARLVDISAFDIRQSYQPERRGGGGAASGSQGEGRSRARARGNRGRDPNEDSILPTVTSAQPLRRDEIAFQRQMAIASAPAGSNRTFRGQLSAPAPAATTSSSPATPTLAPTPAQASSTRNAAATTSRPRSVGPGTGPAPPTDGMEALSLTDTSNLSAEERARLVRHGSVIERAANLLGNDSHKMATFRSHISTYRQGGLTAPQLVEAFFTLFADVSSNALGILVRELADLFDDKSKADGLRKAWQDWRAINEDYPSLPGLGGMQGATSSSSGWASAAAANTGFTIVAPGQRNSTRVLKLKNSTRLGGPAPNTSRGPPGWVPASSSSSRASSSSKAPSSSAFPSLPPPSSSSSSSTAARVSAATSAPSWTASSSSSTTRSRGPPPPNTRAEDAFPALPAAPKPQTTIFGYGKGRGVRRDFGQQESNFQWGATPASSSSAAAQPEPADDGEATGGKGKKGGKKNKKQILVQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C514</accession>
    <name>A0A2T4C514_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1462536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C514"/>
    <dbReference type="STRING" id="983965.A0A2T4C514"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="245" mass="27655" checksum="04C5D9FC1F9F3703" modified="2018-07-18" version="1">MHAMTASNSWEQLLYLYGGDQPWDSLLWVTSDDRVRGGASKSHLFVVNPERARFYGHLDTKTLGGAGFASQHSLGVLDWDLSAYDGIVVSVAQADEKRYALTLKDEIPPRRDDGRQEAGISWEAVFKVPQEGSQYDMKKVYLPWSAFKPTYRGRPKPDAKPLDLAHIKRVGLMMRSFFDEQDGDFSIDFHAIAAWREISDGRPVEAAEQGDEEDDDPKAAVEAAAVKKVQTRRRVWLRRLLCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C582</accession>
    <name>A0A2T4C582_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1421803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C582"/>
    <dbReference type="STRING" id="983965.A0A2T4C582"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015674246" description="superoxide dismutase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="10">
        <location>
            <begin position="54"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="314" mass="31972" checksum="C44ED704B0E203AD" modified="2018-07-18" version="1">MRPSGFLTVLSATLFGCVAAEDAPVVIDNPQGVEFKASLPKKPFFAGAALVGNVKGSVSATAGPAGKGVRFRVQFENLPKTGGPFLYHIHEEPAVNGNCTSTLAHLDPYHRGETPACNASEPQTCQVGDLSGKYGKITSDPFVAEYFDLYTSLQPGSPAYFGNRSIVVHYANKTRLTCANFAKLPVSAATTAPSTTGAHHTAIHGPLATGGAQHNLTGSHSTASHHNLTGPHHTFTASPHQATGAAAPSDVYTLTSVVTVPGSPTTASSTTTTDAGSGGASATSSVVPFPGAASGNRVSLSLLGGVVAAVFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5G9</accession>
    <name>A0A2T4C5G9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1354902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5G9"/>
    <dbReference type="STRING" id="983965.A0A2T4C5G9"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="152"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="642"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="876" mass="98906" checksum="21E0AAF5F5B7E4B6" modified="2018-07-18" version="1">MANTSASEIDSIMSNLRTPTTAPSSPPVDPFDEQEDVGLVDEDIIKEEARARSANIALEEKRRASLLKQRCKKKAETKAEREAKARELDELLQKSAAFSDILTKKTQVLGRVGSSLDGQKLGEHNLQMATQPKCMVGGTMREYQLEGLTWMYEICSQGMSGILADEMGLGKTIQTIALIALLREQEQYLGPHLIVAPLSTLSNWIDEFHKWVPSIPIEMYHGNKAQREEIFRKKIMNHLKSGRPTEKFPVVCTSYEMVLNDHHNLSRIKWEFIIIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSELGDEQGTQQFIEDQMKQDLVKKIHLILQPLLLRRIKQDVAAYLPKKREYVLFAPMTKEQTDLYNVISNKNSDTRSYLEDRAVEMIRSKTASRAATRSSSRARSITKKDKDEKPVSLPLRQSARGKDRSASPANAFSLMMGKRGPGRPPNNAKSTPQSPIIQTPKRKSPPTTISSDTKSAKSSRQSTPLSTRGRRHAGRSYKEADSDEEKMSDDEFEEKLAREMATEDNDNEPPEPMSAEDIELAQTLDMAKKQISRKKLGNPLAQLRLVCNSPHNFYNPWAVATDIPVDESIVTASGKMLLLDRLLQHLFKSDHKVLIFSQFTTQLDILEDYCKELRGWKVCRIDGSIAQADRRESIKLFNSDPEYKIFLLSTRAGGQGINLASADTVILFDSDFNPQQDLQAQDRAHRIGQERPVLVYRLATKGTVEESLLLSADAKRRLEKLVIRKGGFKTMGQKLNEKEEDLDPETLRALLLKDGQVYEGSGGDGILSDQDLETICDRSEEAFEKAARGDGDADAFRVVETGADSIKMARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5H4</accession>
    <name>A0A2T4C5H4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1355002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5H4"/>
    <dbReference type="OrthoDB" id="5367275at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="203" mass="23106" checksum="A41F769F0075BA9D" modified="2018-07-18" version="1">MRRVLLTSGQVSVLATAAMILLCTSALFLSGYAIQQRTLRELRAAIRPRESPKAHLPEEFRGALTDVEESRLLVVETEAQRWSREARGLVPPQSHVSDAEIQVEDTPVEVESKPEPEPEQQKEEEEEKHKAAVPDGEPTKEQLAMLKKIQQSVADKAWAVENPDPLSKNKAPISRAERRKLIKEEIQRLAQSDKPVYYQRRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5N0</accession>
    <name>A0A2T4C5N0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_4307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5N0"/>
    <dbReference type="STRING" id="983965.A0A2T4C5N0"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57754" checksum="63A24BD6F7CA3C4F" modified="2018-07-18" version="1">MANRISTYTMTSRDGDSQNGEPKRNLWTSMLESVASGKRLPEKNLLVLGGTPESQREFLESLAGSEPRRNFDRQKIPPIANNYALGYTYYDVLDADQDDTLARVSLYLLSQPSGEFASLIAPLLTPETIPHTALVILLDWSHPHLWLRQIWTWLQVFQEVLEHLSRDVQTEMEDVMNAWKERGRGGSSVNLDGTPSATVANGDSNGSLPLGPGEWTEPLGLPLCVVCQNAQKIDFLEKSKGWKEPDFDGVLQNLRTVLLRHGASLIYTSQGTTSQLPILIHSTLGITSLLKRQPLKHNVIDRDKIVVPPNWDSWGKIRVLGGSFDTEKVSQYWAEDIKIPLGAPPPSIALPDPEDDDENGPGQPPQVESAIALYEDWCKNPNSGGLALVESAMNEGTEVAVESEDTQEFLERQLKILEAYKSKVPEKTTDGSASGAARKVDYSDEKTVNEHIGPVQFNMGGIQVDADDMLQRLKDRNAHIAADVPSAEAEAAVTNMAKDFDNEQLHDFFSGLMNRTTGAGDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Q7</accession>
    <name>A0A2T4C5Q7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1438590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Q7"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Q7"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline kinase N-terminal" evidence="3">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="727" mass="81864" checksum="31C43BB2C37BB0C4" modified="2018-07-18" version="1">MDDEAVRTPPASGTLKAVQIADPVPEDYIEDDSHHAKQRRGHAAAPPSRRLSGRLSATASPALRPVDDATPSGHHHHHRRNHQSERILAQVGEWLERERKKAAARKLKPRRRKSKSPPSDQTTQAAEGAAAPAPGQPSRERSGSTSSHSSDISFDGLEHILRTSMASIGLTSLPKFSPRVGNKPRRPPSRTSLHRAASSDTDYVDGDAIVPSCDAWLDNSKTMSYTGGASTSTDDVATQVTKVEKEREAWTIFKNEILRIAHTLRLKGWRKIPLGSGEALSVERLSGALTNAVYVVTPPADMPQLEGKKPPTKVLLRVYGPQVEHLIDRENELQVLQRLARKKIGPRLLGTFKNGRFEQFFNAQTLTPTDLREPETSRQIAKRMRELHDGVEVLLHERESGPGVWKNWDQWVDNVGRITTFLDRELEKTPEAARKDSLVHGWKANGYVCGVPWEQFKEMVNKYRAHLNNCYKGHRSIRDRLVFAHNDTQYGNILRIRPDDEKSPLLQPANKHKQLVVIDFEYAAPNTAGLEFANHFTEWMYNYHDPVFPWACNPDRYPNLEQQKRFVKAYVEHRPYSQHSNSTPRMTPIDSQAASGSATPSLHPTASSSSIVDFMLDARYPGGDWNAVEKAREEQVDQQVRELIEEARLWQPANSAQWIAWGIVQAKVPGLDGMAANEELGADDFDYLSYAQDRAMFFWGDVVQLGLVKLEELPEALRARVKLVKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6J6</accession>
    <name>A0A2T4C6J6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1420986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6J6"/>
    <dbReference type="STRING" id="983965.A0A2T4C6J6"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="611" mass="68861" checksum="333D80B26158B545" modified="2018-07-18" version="1">MPQESNAGEAGAAVEPLTENTLEYMLFVIDSQRSDPRKARTRLEVIRKAAIDLAQSLTEDYIWQREGFDLSLKSEHGLLFLHGTTDYGDAIEDEWLIVYILRELSKAHPDLWVRVSDSDGEFLLVEAANALPSWLSPEIDRYRVWIHLGKIFLIPFNPKSRDEPEHLSLLQAVTFLRSNSDALIHLPAIDAEAFHRLQKYPEQIANSVHHALVTIPRTVAYILHALPKIVAPAVEHFYLRDANSLRPILSSSAPLKFPPEDLVTVSVRFSKTLYAQLKSQRFDAPPRWQPLLRKNQELDLLSKEDQKKLERLEMGMKLTCGLEMLAANAENSKSRVVREMAILLEDLEEDGSSALPSDEEIKQWENVDCDDDDSWLDINYEDFERELEGKQAASSSKAKSGFGEAQTQENLRKIVSRFEAFLNDESAGLEGAELDRMDVDDDDEGDDDDEDMDDEVSFDEGVFSEMMKQMMGIAATGTAEEGKNRTVDAAEDVMDSDAEEDRDIQELASRMEAELKEYGSLQLDPPTTNRAIKSKENLDKGKQPMQKESNQQASAADDEDEEIDIDFNLAKNLLESFKSQGGMAGPAGNLMGLMGFQLPRDEDDEEQTSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6M1</accession>
    <name>A0A2T4C6M1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1429841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6M1"/>
    <dbReference type="STRING" id="983965.A0A2T4C6M1"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="130" mass="14063" checksum="BBAB51030EF07FED" modified="2018-07-18" version="1">MIDHTVIVVPEDKFKECLDLYVKAFEPLGYQVSYQFGEYTAGLGSKLDATIADYKLADLWVKGVKEGVTKIHLALRAKDRSAVDAFHAAALSAGGKDNGAPGLRAYHASYYAAFVIDAAGNNIEVVCHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6T5</accession>
    <name>A0A2T4C6T5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1208184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6T5"/>
    <dbReference type="STRING" id="983965.A0A2T4C6T5"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="481"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="599" mass="64564" checksum="F7D58444C7E50933" modified="2018-07-18" version="1">MDQPQKQRSEKLTETHPQGPPNASIAPRIVQRNRPDPSTFHTGSPRPAPRRHPRGAAPPGGAASRPRLRSGPARNAPLDGNGSRTNGPGGIRKPDGRETEKRKGGKKRRSDVVAKWLAHVPGEVMAVLVNMHECYASSVDELRGEVRALRGRMERLSEQEGLLRRMWEGENGRGKGGDVEGEGFDGASVEGVECQGESGVDETTPRHLNMDVPPTLIGERHPVRSTGLKVVKRRPVTRPPLALRQRTEKPATRPSSTDEETPRPDRAGKKVTRAHRLIDNDDGHDDDGLRILDGAPRLCALLRRQHGIASPPKLKSPPRLAHVEPDSNSDEREDEGGDAEYRPGSPSGLPASSSLSAASGASWAPEGSSSSASGGGWRNRATRGSPCAMVTARTASSSSTPLSAPSSTQKRTTRPKPSRATAATRSPSSQQPSSPPPQPPPKTPSPSPSTSASPPSKPRYSTPRRTTLKRTNSGPQYAGKFTFRRMGRTVLSVWNEYKVDGSGGKPFRCIESLEKEYGTCWRTGSVGDIKYASNYVGVRKKIVDFVEGMCEGGKMTPEEACAQLDERVDGRLQALITVLRKGLDPFEAIPVRAGKSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6V5</accession>
    <name>A0A2T4C6V5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1208942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6V5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="12049" checksum="CD56A1374E50416A" modified="2018-07-18" version="1">MRALSAGRSLVGATGGCAMLYLCLCSATVRSDRDGVVLHILLNTCSWFEGPFLPASCLGVSTFMLCLNNSHQLQHHHQSAIHRKQHHTNPRLSPTTHLQVSHSPRPPRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Y6</accession>
    <name>A0A2T4C6Y6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_278063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Y6"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="373" mass="40043" checksum="FABF81540EF1E628" modified="2018-07-18" version="1">MAWAYNTPDGTPNNGPTIAAVALSVTSLAFIALCLRMYVRTRIAKAVGLDDWLIIASWVGACGYTLATVVQTKWGLGLIELDSMPDENVLNFGKTQYIGAPFYVLGIWGFKTSLLVSYVRLVPGTYRLIPISIAVIVTMAHIAFLLVFLFLCIPVEKQWEPLVPGHCADAVPFYLTFSSITIIFDVTTLILPFPILLKLQMKIRRKVALLCLFALGLFVTIVQIIRIQTIRNLTNYLDSAEAIKWSIVETAVGIVIACVPTLAPLITYFSDKTRNNSGGGGGGAAGDASTDGMGKSGGGNSSRLGGGEGPYALQPWRATKSGMRRADEENDGEKSTENILWRTVAPSVSEGSVVSDGGGSRGEDRAGGSKMHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7M5</accession>
    <name>A0A2T4C7M5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_283404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7M5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="132" mass="14309" checksum="8C9B6EAB5F991C01" modified="2018-07-18" version="1">MLPFLSQPTPPASTRASNCELQLTSKRSVPTKPASSPALSPQHRPRDEAATGRARSRCLRDIHRPLHADQLSAPARYLPVTPVPRQSRPCPSRRLAAAWLPPQVSPLSCLGYAPRPAATQALQAIFTPPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8N6</accession>
    <name>A0A2T4C8N6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1462458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C8N6"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="717"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1501"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1507"/>
            <end position="1526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1588" mass="175402" checksum="44AD082324270FA2" modified="2018-07-18" version="1">MSDPEDASPPGEPVAELENPASVIENSDEADVPQLEQQETTEDASSTNAEEKENHAIEGGQLNDNAQNEELPEITSADASSIDAIPRRAGSPMESVTSAPGDSPSVQGSHLSSPSSSVLPSFASRPGFGSPTPSFRPFDRRFQSRIASFNTLSPRPTSPAYVPNHSRHASYASNFPSDQPDTDTPSPPWEVVRWTRLKKLNGYAFSESGRRNFGSPTCLAVSASIILGTSKGIILIFDYSQNLKTIIGPGTKAIESGPITALAISADHTVIAGGHANGNIFTWDTGRPSRPFLTIPHLDGAQVQSRTVDGHMPDASVVHLGFLGTRHTALVSADNHGMAFSHLASRGTGPLGRTVKTTRILGRYPNAPMQPGKTIKPSAVLAFAPLPLGNIERETDKMGLTAMLTPYLLVIVSTTPVAQTQHKSARPKDVPAHSAMTGCLAWFPAVSLKFADAHTGSTTSKAKLAYCWSNVLTVLDVDEIPGDDSDPPSLRFKARSRWKCEEAIVAVQWLSRSVLTVLTISQRLIVLEDRTMRMTEAFDLLERYIYHTDLFSHQLHSLVENLDENDVSMHGVVADAFYMSFKAYKGRMFLLGFNDVSIGALSNWADRLIATMEHGDYIGAIQLATSYYTGDANKLTVGLPDDTEQRHNMVRDKIMEITSASLKYAFAQRQKSRASVDDDHLKQLAETCFVACQTIGNTDYLFEEVYEWYSDAEAEGIFLENLEPFILDQSIRIVPPTVVKDMVSYYVAKGWESRLEELICHMETATLDLDQLTILCKRHNLYDALTYVWNQALQDYITPMIDLLSLLVPLMSNGSSIAGNTSDDYYGVNAVKIFPYLSYVLTGRVYPSGEAMDEETANKAKAEIYWFFFSGKTISWPKGSGRKFLTRADGGPEPAYPYLRMILKFDAPSFLSALNEAFEDSFLNDSSEDRPNGTGLKADMPEEQIFGMTMNRQYILSILLDVMNRSEFAPADTIYLDMFIARNLPKFPQYLLFPGSTLSNVLTGLCNYPGPDLAEDAQLSAEYLLSVYHPSDMPALMPLFKQAGFYRILKRIYKADKQYGKLVETFFEDPEDQDLVFECIAECLRPQSGLNRRQEQEVLAVVEHHARDLLELSPERTASTLALQRTELHQHILDFADDAPELQHAYLKTLLEPENPLADGQHTHERLLVERYVRLMCKFDAQHVSSYIGLVQSVDLQLDSLLPTMEETGVVDAAVVLMANAGQVTDAMARLVRHLGTLESAMEGLLRPSDTHDGEEGADSASLSLEPSAEALLESLQNYVHVGIWICQEQTRSTRRVSVVSKNKASQDTLSTDERLWLSLIGACVQVTQNLSPLIHAAANEHGFDEEKLLAKLRSLVQHTFTSLLVSTSSQDSTQANGQLNPKALASPGSNLSFLRVLRAFLTNAAASSPSLAELRHVLASIFSAYAYEESILRLSNRLLERSLFTSVNTSVELRQRGWRPRGSTCEACGKRVWGPGLAGATVFEAWEDKQAAEEVARKQRQLQAAERAKGHARVSDRRSKGKSLDTRPSSMLIEQLAGKSNKDQVLGPLVVLACRHIYHQTCLDALQEKQENGVLPRELDYKCPIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Y5</accession>
    <name>A0A2T4C8Y5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1420184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Y5"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="290"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="519" mass="60106" checksum="38D2E2013E6118ED" modified="2018-07-18" version="1">MSSAPSTDTSWNCLPPETRQQILQALLEQHDCRLAPYATVSREWQAVIEPHSFSRIRLTPSRIEDFQSMVHRNRAYVRYIWLCVELAEYNCFMCAPMDPILRGFCTTDSFRLMTALLDVFTVLSRWESRDSLQLDISIYSVSDSEHWFKYLTFDPDDPFKKGDRRRRIERAIRDKCDDWNHGWRGGRRSSAPDSWAMHKIFNEIMGDGPFSEDEHAHDYWQLLPLVPAVTSVLLRQQNRRRWKPTALACILGRLPRLREVHYEPWRPWVHAQQVSTDEGMQSLLQALASRQVRRLILFETSCPQYLLDFPNFNADRGSTVGISRAMARASLMLEHLSASFMVEASQFFAARDPYWRWRNLTWLALTSRLLTPVEDPDTRDDMLRAAAAAATAMRKLETMEIWNGSEGLAMVFRYKRAPSRGTAEILIRGTWELTLHPAVVHAWEAVARRHCCYGCAIERESLDAAAITSYGDAVHYLRLSNPVIRPISLEQIRMEQRIRDGTFSVSSREEEVNGELDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9P1</accession>
    <name>A0A2T4C9P1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1188391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9P1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18336" checksum="CD859B6013F712BC" modified="2018-07-18" version="1">MFNPQVINHLGKSDLFFPTYSTPSSSTRPLSSLIFPWRPPSLAAYLPLLCAFSYPGLGVALCSSVAFDCALPTCAGSVRFIDGSVICLLFYLLFTEIPTIPLKSNKELKSIHLPFGLSVCKMVVFRGCLTCSQVFTRLWKAITRSVPMLWNLSRGSFGRFSHSSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9S7</accession>
    <name>A0A2T4C9S7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pali-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1328517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9S7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9S7"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF7">
        <property type="entry name" value="PALI-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="216" mass="23177" checksum="158340B90506BE77" modified="2018-07-18" version="1">MGVGTFFHYFGTVLLLAATALLIVVSVTAPVVNDLSLLRINFSGSSSVDRITFGTFGYCIQNSNGHDACTHSHVGYEGTNALTQVTSLNFSKSDRDGFRILTKVMILHPIAAGLTFLAFLLCLGTSFLGSFIASLFSFLAFVATVIAMACDFAGFEIIKHAVNTRGPANVHAHWGAAVWCILAAAALTLIATILVFVTCCAGRVKNRRTRRSKTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA45</accession>
    <name>A0A2T4CA45_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1399564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA45"/>
    <dbReference type="STRING" id="983965.A0A2T4CA45"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="10"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="670" mass="74579" checksum="D262711C9FB24668" modified="2018-07-18" version="1">MALSPHEVAQLRVALQDAVVKCSERCLYQSAKWAAELLNAVPESEEAEDDAASADLKQTSPIFSPNQDADEAALEAKELSKYLLAKSLFDCKEYDRCAAVFLPDSLLSTVLDSRLEKPPVAAKGKGKSKATDDAKQSALPLPKLSQKSLFLALYAKFMSGEKRKNEDSEMVMGPQDLGTVVNKQLLIVGRFLAAWFEEKTTDDDEVLGSQGWLEYLYGMVLAKEKNDEKALEFFIRSVHKYPMNWGCWLEMTSLISRVEDLNRICRHCPQNIVSYMFHLHTSLELYQQSAGLANSLDQLLSIFPTSSFLLTCNALLAYHAKDLMAAEQHFSRLLSLHPHRLDSLDHYSNILYVLNLRPKLAFLAHLCSSVDKFRPESCVVIGNYYSLLSMHEKAVGYFRRALTLDRSCLSAWTLMGHEYVELKNTHAAIESYRRAVDVNRRDYRAWYGLGQTYEMLEMHTYSLWYYKKAAGLRPWDGKMWMAVGSCLQKMGRERDGIKALKRALLADAYYDVGSSFGSGGDLLGARGATGQMDPEILLQIATMYDQLGEEEEAKAYMELCMAQEDGGPAAAGNLGESVRIHNDSPGGSEGYAEREDANAEGNAEGTGVTAATSKARMWLAKFAMRTADYQTANRLAAELCQDGVEVEEAKALAREVRSRLEASGMLGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA65</accession>
    <name>A0A2T4CA65_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucan 1, 4-alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1328931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA65"/>
    <dbReference type="STRING" id="983965.A0A2T4CA65"/>
    <dbReference type="OrthoDB" id="3941134at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="75604" checksum="650EA5ACFDD44419" modified="2018-07-18" version="1">MEDPWGSPWAVDSPARIELPAAPQNAHFSADHLFPRRGSRSPAPSRSRSPAGWEDDEAWGGWNGGGAASEGGSGKESPGWGRSPGLKPLQVVAPPSVRSLSPDPWREVALKRLDTAAPEDEGGRQPGEGGASETSGDDRAVNSAISLGEEQGLRRGEELKINMPLAVPQLDIDADGAWDAGVAPEAPAVDAVIPAILLERPDLSLDAGVSVLDAVREEEKHGVSTAADEFIREEEATVFPRGFEVEDQSEPTAAIEAVNIAAGVAAVVSEPEISHPALPTEAELAAESQAWQQESQVKVSKAPAVSGGVDGLGVPAPTVPLEAVELAPSRASNKSGLHFPIDLSLLDELFPSTPAITTEPELVPDVIIDDTFTSGSERRAWYLISRFGSIRKHDMGDDDNYVRVGWAGSHIREQTTQTVRRWMEEDSITGRVVLGRRLGGSGAAMFNWNSSAPPVEIGEFLGRHSRNSSMTVHSAVASPTASSFGWNSSAPSSPAAARHPLAKEVPQGDAREEPSPNKETKADSALQSLSLAPPPPHTARSHIPTPIHIPPTYSIQQDEDDDDWGEMMTATPTTSMSFPEDEEVASKRHSVPPQSAFQFETAVESPNLIPPKLEKAPSKRPFSWHLGQTLSKPFRRGPKTPSTPSFSSPLSRPLTPPQVAQSVTPHDGHDVSAGVSFIQPADGPHLSAEDEETVARLLGDIPDLTYMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAA9</accession>
    <name>A0A2T4CAA9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1399645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAA9"/>
    <dbReference type="STRING" id="983965.A0A2T4CAA9"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051600">
        <property type="entry name" value="Beta-PGM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193">
        <property type="entry name" value="6-PHOSPHOGLUCONATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46193:SF18">
        <property type="entry name" value="HEXITOL PHOSPHATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="245" mass="26589" checksum="20E5D2F43877DFA1" modified="2018-07-18" version="1">MPEIKAILFDCDNTLVLSEELAFEACADLINKICAERNVSVSFTGETLIQEFVGQNFRGMLTTLQKTHGIDISPEDLEKYVLQEEDAVIAKLKAALRPCPGVDEQLEALHKAGKYQLAVVSSSALRRVRASIEKVGQDRFFPGDVVFSAATSLERPTSKPDPAIYLHALKVLGKSAAESVAVEDSKSGTLSATRAGIKTIGYVGPYADSKKDEMEKVLRDAGAVVIMRDWSEFPAALAKIENGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB08</accession>
    <name>A0A2T4CB08_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1429623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB08"/>
    <dbReference type="STRING" id="983965.A0A2T4CB08"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18571" checksum="F19D8F8D4FCFE25A" modified="2018-07-18" version="1">MFANLTHATLRFVAFFNHLMILASSAIVTGLVSWFLDKYDYRGVNIVYQEVIATITLGFWLVGAVLPLVGKYRGHLAPINLVFSYLWLTSFIFSTQDWSSGKCSFGEPGEGHCASKKTIISFNFIAFFFLLCNTLVEMLLLRAEYATPVTAAHNKELSAGRPSDATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB15</accession>
    <name>A0A2T4CB15_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lactate/pyruvate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1399876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB15"/>
    <dbReference type="STRING" id="983965.A0A2T4CB15"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="461" mass="50870" checksum="D63D3A37BAD79959" modified="2018-07-18" version="1">MAQHNRPPRQTEPADDLAKGVVATARQSWRDLFVWKQRVVITNGYGETRCEWHEPDRFQNPISLFAQLSARDWLFFIVGWLAWTADAFDFHALSIQTVKLSKYYGRSKTDITTAITLTLLLRSVGAAVFGLAGDKWGRKWPMVFNMLVLGALQIATIYSTKFTTFLAVRSMFGLFMGGVYGNAIAMALEQCPSNARGLMSGILQQGYSMGYVLAACANLGVGGATDSWKTVFWIGAGLSIGVGLLRILFPESQQFLEAKKAGKKASSPGSFWRETRTMLAKEWKMCVYCVILMTWFNYYSHTSQDSYTTFMLEQKMLDNAGALSATGFFMQFFVQGAWGVIPIHLNELSPPAFRSSFPGVTYQVGNMISSPSAQIVNAISEKMFVTVKGGKKAEAYGPTMGIATAIIATGIFVTVMFGPERRGRNFDGVVAGVAPSHSDSKMVDEPMDEEKAAVELAEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBE2</accession>
    <name>A0A2T4CBE2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1399962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CBE2"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="873"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1307" mass="148009" checksum="5E378C6892899A79" modified="2018-07-18" version="1">MIAVESQSGSNGPQTVDTASTTNGPTPLGSSRDGQSAGGIGGNIESTTQDTDKFADEIENLKKMIQQLERKQKGAAPLDAEQEAELAKRREFRENYKRMEDCLYQHRKDWEISNKPDWWNLWSNNDYFQDGRNYRYWNMNYSNEYERPDPFEPSHNCGDTKAHVKSGVYEEFDREIDYGHRRERLRKNFEWDMDRLYLAEEAEKRRREKEKQVEEEVAEQENDAEEVLDAVKTSPSNFTITKQNRVRWPAFKALHSIDEEKAHVIDILIGEPTIDDELRQYRWYGHSGQRRRKVENIRDRKAQETNEAGLAPLPERVRIHSSILRYILAEILGSMADGSLADMNISSVVFIRPFKAIFYCRGALHDWYTALEKKLKSASEAEKNTLAVSEGQQTEANPDAHAPGDGPEPALAEKAPAVETSSEKQHPSDVQLVEDAQNNVNDGARADGGREDEDAEETDAEEEEDKEKGSTDITKSPTALLHLRCLLDFVDSDISKRLEYLQGPQCRKIVFSDLWLLFRPGMEVIGRDGKQAYRVISVTSANHRVASAWERWYSNPTRKSSAFNITCIYIDFDGKNIGPVTKVFDFKRFEGEKEVTLLEVYPLRLHPVKQSDFDDSTCAEIRDLPPDQQYRQKLIRRGTMFLEVAAVKHMYYVGPTLEAREDVEGQVVVDFETAFSVEDETQKEWKPLLQTLIGNTSGQDQDDDDEMRTCRGICCANDYIYNDINVDEQQKTEYINSLLPSVTSLNEQPSIAILPRPLSDLRPSNTNATGASDDELVIMSYRVFGFVLRNRKWAKLDLTYMTAIHPPDVENVLADEQKRNTTGLKKQKTAFDSLVIKKEHRSMIVSLVAQHFRDKKSTSAHQQQFDIVKGKGKGLIMLLHGAPGVGKTSTAEGIAELFKKPLFQITCGDLGTTAAEVEKALEVNFALANRWDCVLLLDEADVFLAERTKEDFKRNGLVAVFLRVMEYYAGILFLTTNRVGDFDEAFTSRIHVSLYYPELDAGNTLEVFDNNLAMIEDRFAKKNRVININGSSIRGFATKHYYEHPQARWNGRQIRNACQTALALAEYEAQGNSHEAILKPDAVINLNETHFQIVKNAYLEFTNYMNTLYGTGPAQRAKEGRLRAVWVDENNCVVDGTGMSHKTQDKKAAFLKATQGQLPQQVFIPNSPPQPQQYVLQQPQFAQGFQGQAPQDVQQQQLFQQMGMQQQQQQQYQHQNIVAPQPVYPGSNPTQTPHNSVAQTWNNPGDSPGNASFQASTAGQSPLQIPRSMPTQQSAGGYPLTGQQQQQPTAHQLGQSMQGVYTAPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCT2</accession>
    <name>A0A2T4CCT2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1460914</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CCT2"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000349">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="212"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="468"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="312"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="901"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1165"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="718"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
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            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="994"/>
            <end position="1026"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
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        <location>
            <begin position="1055"/>
            <end position="1132"/>
        </location>
    </feature>
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        <location>
            <begin position="1141"/>
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        </location>
    </feature>
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            <begin position="1173"/>
            <end position="1186"/>
        </location>
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        <location>
            <begin position="1187"/>
            <end position="1206"/>
        </location>
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        <location>
            <begin position="1207"/>
            <end position="1218"/>
        </location>
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        <location>
            <begin position="1303"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1369"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015110"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00020728"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PTB79332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1472" mass="158522" checksum="866FFF15BDBE701D" modified="2018-07-18" version="1">MYSNSNAFLGGNSPRPGTQSQQQYGGSFNNLGPGQQQQQPSPFAPQPTGYGQQPLQQQFTGYPLQTQPTGYQSMPQPLQQQYTGFPGQGQPPPPQQQFPTSSAPPMPSIPPQFQQQFQQQQQHQPPQQPQQLPQLQPQVPQPTGFPAVPPPQQQPSSTISPPPAPIKPQPTGFAEVAASFQTGGTAKPQGRRGEKSHSKIPNIRLSFITAADQAKFETLFKSAVGDGSATMSGEKARDLLIRSKLDGESLSHIWTLADTTRAGQLYFPEFALAMYLCNLKLTGKTLPPTLPDHVKNEVSSMVDIISFSVADEGPAGNQSNNVPTIEQPKPQPPPASNSQLLQAQLTGFPGAQQQGFGGQSQGLQPQPTGFNNLQNPQPTGFNGPLPPLPPMPTGFGGPAGGGMIAPLNAQPTGVPGQWGLVNAPASGLPNIDALQARMMPQAGREAGSFTTAGLQGNAVIPWAITKEEKTRYDALFKAWDGLRKGYIGGDTAIEIFGQSGLEKPDLERIWTLADHGNKGRLNLDEFAVAMHLIYRKLNGYPLPNVLPPELVPPSTRNFSQSIGTLKSMLHEESDLRKNSGAALLPQKTGVSYMKARSFRGGASPAAGGRKDATVFRNDDEEFGYRSSARRRLGGASPRAESPAASSVGSNDDLTLDELRKKIREKQVLLDAMDFADEKNHEEDDILDRRDRREAEELYRRIRRIQEDIDAHPDAALAVGNSDAEARALKRQLQKLTDRVPELASQVRKTEKAIMEARLELFRLRDAKAHPGSASAIVGTGPGGAVTESDRLKARAKAMMQQRTAALTGKKIESTNEDFDAPKRLEEESIRVRNEKESNERMVHDVEESVREFSRSIEDSLNDAGKDNSSEHERRRWEDALGVEDEVRDFIFDLQRESRAARIRAQEKRSGRPTTADEAPRDRAAVAPQRTESPASTSRTATPSSTAGGGSYSSYKTPEERAAFIKQQAEQRMAERLAALGIKAPTKSGETAAQRIERERSERAAKLRQAEEEDARREAERQARLAEEQGIPPPAAAEEPQSAAKKPPPPPSRKGGKSEADAAKKAEEEAAKAAEEERLAQEHAQQQRETDEMQQKVREEEDEFAKEQREAEARLKALEEQVRQGKLRKEEEKKKKKAAMAEAKEKEAKLAARRAEIEAAKQRELELQRQLEAMNDDDSSSSDEDEGQQQATPQASTPTPEQRVSSPPVAPAPQAPPALPAAASIPSPPPVPTVVTSPPAETESKNPYFKMMSQSSEASSPAVPKETPAAPAPDVSTNPFHRMTQDIKTAPVPTPAPVQPWSRKRADSDDWGSDRDSEDEDSDDDRPGGGNAAQLASILFGTMAPPRPLSAAGRDSAHSTPAPANDAIASPPPLPTGTPAGAPPPPPPPMPDAGSPPPPPPMPPMGGPPPPPSMPGGIPPPPPPPPPGIAPALPAAGGGRPAGFLGEIQAGKALKKTTTKDKSVAAVAGRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD62</accession>
    <name>A0A2T4CD62_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD62"/>
    <dbReference type="OrthoDB" id="5366485at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1460.10">
        <property type="entry name" value="Nuclease A inhibitor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="234" mass="25701" checksum="A5D4B4681F249583" modified="2018-07-18" version="1">MPTLHKPILSALSLLATKRAAPQTFARQIIRLLAPTRTSTTTIIIPRISSAPTTPRFLSSTPPVRKMATDEDYMAFLNKANQDADEGRASAQRSQGGAAATQRTFKATDDGAEIPKSIAEALRDAFYVSEADEPFNGVSLRWKGEGGLPDEVEFAKLIHHWDPENAQIDIMDPVDWDSEGQYANIIDAVREATKGNDVRVYRVARDLTRAEYFVISRDDEGGRIVGVKALGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDA5</accession>
    <name>A0A2T4CDA5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tho complex subunit 7/Mft1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1326211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDA5"/>
    <dbReference type="STRING" id="983965.A0A2T4CDA5"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38829" checksum="891858CF2C57107C" modified="2018-07-18" version="1">MASWELLDEKGESELHKSRLLNVEEKPFKRITKRLSSISAIVSGAIQSGSTAQNGQTISSAQLQEDLTFDFAAFDSSIARFQFLHDANVRERQRYEADKQRILAECQAARENNARLREQLEDAKATLARRKKFDELAEKILSNRLLRPREDQFAALEKLEEECKELERESETYSGTWKERRDQFNRIMEEGMLLRRQIRDEKEEVDRREGMNEGGEDEAEEQRGGQTPGVEPSATGTPRPDGEGTLNETPQPTISVDAPTPSVSSPRPDRLQQLSAEGTGSRAASRASTREFSRTRLREGSGSETGEDVDMEDSRREEGEEEEDGEEGEDKAGARNGDKMEVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDE4</accession>
    <name>A0A2T4CDE4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1173493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDE4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="268" mass="30471" checksum="F8615DF6EBE7D12B" modified="2018-07-18" version="1">MGVRHDGSSEIWGICRVRSRRKQPRGLGERKIRRRRSDEARRNRRQIGCRHGQGEVPGGRGRGTAKRSDKVAEVRCLLEIRPEIRRAGEEEERWKEGENNGSRRGDEIGRRTEEEEEGREITDRLRSVVYSRQLRREAFSRQAPISTARRQTGCNGYLAAGATVKDRHASFFVPPSISPAPWPLQQEARANYPRQGRLRPEIRHRGWAIWCCLSRFPEQSVSDRLASSGRGSEGGWPQGPGGVWLRCSAISSVFVISGRGLWRLGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDK4</accession>
    <name>A0A2T4CDK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1398918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDK4"/>
    <dbReference type="STRING" id="983965.A0A2T4CDK4"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="75" mass="8015" checksum="494441B583E08595" modified="2018-07-18" version="1">MDAKPATFSLASAPVTSPTASTTTASKPKPCCVCKDEKARRDECMLFSTAKDPAADCRSLVDQYKSCMQGFGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE34</accession>
    <name>A0A2T4CE34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_48799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE34"/>
    <dbReference type="STRING" id="983965.A0A2T4CE34"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="919" mass="102714" checksum="94600C84528E6783" modified="2018-07-18" version="1">MYRPGGSGPRARGSILGALKASEMLDARARLPAEIMVTILNYLPVADQMRAARVCRRFQEMVYDDTRWVSRLKSMGCWDEREARQRFEEALRRRREAAAAAAAAAGQSTDGTGRPHAVASATIFDATIEQQRRQRPMSELRDGFETMAIGTSDPAEDPAAYLDVFKRVRSIRGGARQEYGKIYKALAPFYFDLVKAKSHTDPIVFKAFIDPEQQAQMLANLHRFAGSDWAEGWAVRDAKLNTMMNIFEAAVLREFEQGYEFWDVDGRMRRYAHVLHTLNGAKTGIELFIQKHPLFNDRELMHNPMDCLNQAPTDDVTLEPSRRFFEHVLAKVNEQAGILERIFPNPAIVFWALAEKVAEDVIAEYTTPMFDEAHERSILSYLKAVSGIFEQTMRFFESLTPPKGPAEEDITERAKQLTLKVFEPHLDLYLQEELDYFTKQAEIEVSQWEKKLSEQDSSLESFYMSNINRSAEKNDFLSSFKKVIMMPVTVLPNFPIGSPFATTKPTASAAITANGSAALTPQSSRPQTPGLGANEVPGRGSSPMPGGKAPTDELAAKAAIIASKLEGIKSLFSIEVALDLVHKAKGSLGRAAVLIPLGGQVGGEAREQCANIFIALVRILGQRHVKLGFDMAVDHLSQYNPRNVSDHDQKGVAPLVMFIELVNVGDLISQMIDVFYEQQLVTPKISDKNDFLDPAGLAKKKFEQMLDESVAAGLNKGIDVLMDEVEYLQGTLQLPTDYNPTPRTPGDDVNNRLSKRATVGSMAELDIGPTETARRIVELVRSHTNMLVGTTEKSMLDVFNGEVGQRLFTAICKHLKRQRISTDGAVKLIADMNLYSDYVRSLRNQDVLPYFGALRELSQIYLIDAGHAKEMATVIADGDRFGGVFRAEEVYEYAQRRADWYQVRRSVERAMYGMDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE58</accession>
    <name>A0A2T4CE58_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1435638</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE58"/>
    <dbReference type="STRING" id="983965.A0A2T4CE58"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="14">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="235"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB79859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="667" mass="75283" checksum="84D25167BFBF300E" modified="2018-07-18" version="1">MHPFDPIRPEEISLATSILKASLPGISLRFKVIDIQEPIKQHVIPYIEAERMGQPLPQPPARLVYSYLHRLDTHAFLKAVINLDTKAVVSLKELPKHVQGPVDVDEMIGLETICLKHPKVITEIEKLQLPEGVTVCTDPWIYGTDDEAEHRRLVQFYMFIVPVAHPQSNHYSLPCAFSPVLDANSKELVRIDYLPTGRGHEVSETTQPWKPVKAVEYAHELLETPLRTDLKPLIVQQPEGPSFSLDGQLVNWQKWRFRVGFNYREGLVLYNVTFDGRNVFYRLALSEMTVPYGDPRRPYHRKQAFDVGDVGLGITCNQLSLGCDCLGHIKYFDGFRIDSEGRPVHLRNVVCLHEQDAGILHKHTNYRNGEATVVRNRQLVVQMICTVSNYEYIFAWVLDQAGGIEFEVRATGILSTIPIDDAEGLNLPWSTPVGPGVSAPYHQHIFNLRVDPAIDGFNNTVVYEDSVPLDPEEHGVEDPYGVGYVARTTVLEAAGFADTNVELGRVFKIRNDGIVNAISRKPVAYKVQTVASQRMLMSARSFNARRARFHEHAVWVTRYRDGELFAAGEFTNQSRVSTGVDTWAARGDEIVNQDVVFWHTFALTHNPRPEDFPVMPVERLSVHFKPVGFHEKNPALDVPHSQQGANKSTLVEEVAKEAKEAKDCCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF09</accession>
    <name>A0A2T4CF09_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1369034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF09"/>
    <dbReference type="STRING" id="983965.A0A2T4CF09"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="263" mass="27927" checksum="565599BB303FE6EE" modified="2018-07-18" version="1">MDRQTIMETNRSLRTIKNELESLLEKGVIDEAAFDTIHAALPAETPLRGAAPGSAARSATQTPAQPSAAATPPVQAFQNLNVNGVSPAPPSYEDTPAPNLPTRTPAGRPVLAHARALYRYEASDGRDLSLEKDDKVDVYEYMNQDWWMGRNHRTGLEGIFPQNYVFVEQQQKAATPAPAPVAYPQQPTYGYPAQSQGPPAQQNPYNASVPPMAVAEGGQPGQPGAAGNGKVGEYGKKFGKKLGNAAIFGAGASIGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFA0</accession>
    <name>A0A2T4CFA0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1348027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFA0"/>
    <dbReference type="STRING" id="983965.A0A2T4CFA0"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="17800" checksum="C932822CB8765B8C" modified="2018-07-18" version="1">MSVLEVGDTFPGNVSFTYIPFTPESKDITSCGIPTKYNASEEFKNKKVVIVAVPGAFTPTCQASHLPGFIQNIDALKAKGVDQVIVIASNDPYVMSAWGKANYTKDDFIIFASDSELAFSKAIGWTQGDRTARYAIAVDHGKVVYAAKEAERGVDVSGAEAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG41</accession>
    <name>A0A2T4CG41_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG41"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="192" mass="20687" checksum="FEA5DC0C19D6B233" modified="2018-07-18" version="1">MASKQPTTSKDEMTSALSSLAIETPKPITTSTSTSTSTSSTQTKPKPKKKTEPIADSWEDESLSEEEDAAEPASSSTPSSLTTPAVPPPTPASPLALDSSYEWDTLAANQGQGQSSGSGSGTPARRPEKTDAVARRMIAAGLGLKAPRQTEEQRAYQRSVREQEKRRREAQRAEEQRLREAAERAKAAVWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG82</accession>
    <name>A0A2T4CG82_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1419118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG82"/>
    <dbReference type="STRING" id="983965.A0A2T4CG82"/>
    <dbReference type="OrthoDB" id="4850431at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="17284" checksum="2263F2DB8F7EB337" modified="2018-07-18" version="1">MATTDSFHNIQMTVVPPPEHDGSRGRTRDRTMPITNSKNLRPDESSTLRGRSRRRSVSPFSLASRGSSPVKPSANRLMLHNRLREKRREHCPSRIASPANSEVLHKQTRLRSRSRGPRRDKEPHRPVDHLSSLRNEVFLSDEEQPNHGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGG8</accession>
    <name>A0A2T4CGG8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1324875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGG8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF201">
        <property type="entry name" value="MFS AFLATOXIN EFFLUX PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="88"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="584" mass="62958" checksum="00F092610CFA556D" modified="2018-07-18" version="1">MAVPEEKVVAEEAASPIQLPRTSASSTEVANTPTTAYLSDEKPGPIPTQEQTIAQPANSDNEGANLQAPAPDSAEDNYKPKSLKFWLIIVSAFVSMFLVALDRTIISTAIPTITDDFHSLSDIGWYGSSYMLTTAAFQLVWGRIYRFYDLRWTFLTCIVIFEIGSAICGSAPSSSVFIAGRAIAGVGSAGITTGSLLTTIDLIPLAKRPMFQASFGLIFGVASITGPLMGGAFTENVSWRWCFYINLPVGVVAFILLFFFLRVPPKPKAPASVKEQILRLDPLGTFFFIPSTVCLLLALQWGGSVYAWNNWRIILLFIMFGVCALAFALVQIKMPETASLPPKVISQRTLLCAALYMLFVAGAMMLLVYFIPLWFQTTHGISPVRSGIYTLPLVLSLVIAVTMSGLITQRIGYYMPALVIAPCIMAVGEGLLFTFKPTTGSPHWIGYQFLAGFGLGFGFQTANLAVQATLPKKEIPTGVSILFFTQQLGGAVFLSAGQTVLNSLLVSHLKDVPGLDPETIVKSGATELSKAVPPQFVSAVVDAYNYACTHIFLVALALTCAQLVAALGIEWGSVKKPKNQPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGU1</accession>
    <name>A0A2T4CGU1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1324931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGU1"/>
    <dbReference type="STRING" id="983965.A0A2T4CGU1"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="767" mass="87696" checksum="37A26DBD53F71DE4" modified="2018-07-18" version="1">MAPRKDTPFRSAEMSMVQLYVSNEIGREVVTALGELGLCQFRDLNEDVSAFQRTFTQEIRRLDNVERQLRYFYAQMEKAGIPLRKLDLDAEKLASKVAEHRQQLPPLRDEVEDPGEPLEQTLRGNLYMNQSEIPEPLIDPTNNEAIQKNVFVIFAHGKEILSKIRKISESMGADVYNVDENSDLRREQIHEVNNRLEDVQNVLRNTQATLEAELTQISQSLAPWTVLIAKEKAVYSTLNMLSYDSARRTLIAEAWCPTNDMPLIRSTLQDVTNRAGLSVPSIVNEIKTSKKPPTYLKTNKFTEGFQTIVNAYGTATYQEVNPALPVIVTFPFLFAVMFGDLGHAIIMLTAALAMIYWEKSLKKVSFELFAMIFYGRYIALVMAVFSVFTGLMYNDIFSKSMTLWKSAWEYERPEHWSEGDALEAHLNPHGYRYPFGLDWAWHGTENNLLFTNSYKMKMSIILGWAHMTYSLCFSYINARHFKKPIDIWGNFIPGMIFFQSIFGYLVVCIIYKWSVDWQASGRNPPGLLNMLIYMFLQPGKLDERLYAGQEYVQSILLLLAFVQVPILLFLKPFYLRWENSKTRARGYRGLGETSRVSALDGDDETEALANGHGDSFDEDGGVAMISQDIDEDHEEFEFGEVMIHQIIHTIEFCLNCVSHTASYLRLWALSLAHQQLSVVLWDMTLGPCLAKGGVLGVIMIVCGFYLWFFLTIAILVCMEGTSAMLHSLRLAWVESFSKFAEFAGWPFAPFSFSTLIEESEELKNYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHC1</accession>
    <name>A0A2T4CHC1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2406 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_15480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHC1"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42933" checksum="28E75F3C677C6F7B" modified="2018-07-18" version="1">MATPGDKERGLPSPTQQAFSQQPAAQTQTQTQQQQHQQRPSSRRFSFLSDKSRKNSATVKIDLHETHAEKDSRRLHSKADPTLAMNEAEPSVEAIMTASSRPPLRSIQHKDAYGNVIADPDLSNPTRNRWERPLDTIRSFEAAIEGDFARRSMHRSETDPSANVSRRNSYYRANQPRFPQDSYYGSRAASFRGEGSQFGPPPPMSARNSYFDNQHYSSNGGYYTSNAGPSGGRRPSREQTSRMAMASEPQLRTYGREQNVYPLPHKDRSYETVTSAAASGNSEAAGYQTDPTSSDNSSIHRTSPAKQVNDYGIAFSQSQSYKPPMLTVNLTAPASKMPTPPNASYQNPQSAIPRKDASLLKRQVSTTPSGGEKRKSWFSRRFSKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHE1</accession>
    <name>A0A2T4CHE1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHE1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="12780" checksum="B3D27D499785BE03" modified="2018-07-18" version="1">MSFCGLLLISRSEPELLGITGSARSTDAQRILTVKGPSRAGAGSVCAASCAVIIIIDSLLINTPGQGPNILSFSMAAWASGGDDQASESCFCLEPVGMMRQLLQASSANITVQCPTQGQMGCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHE7</accession>
    <name>A0A2T4CHE7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PhyH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1396154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHE7"/>
    <dbReference type="STRING" id="983965.A0A2T4CHE7"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="388" mass="43148" checksum="857F518C318BF8D2" modified="2018-07-18" version="1">MRLPAGFDAGPGAKKRTSPHLRPLTSTASYKSKKFPSRKTLTTIIPTTPLFFTIFHLSLRLFTFQHCLIFTSPAMADPTPGLTPEQLAAFHKDGYLIIRNALTQETVSSLLAETRHLLESFSLKDHPLTRFSTGEKSDHVGDDYFLSSGDKIRFFFEEDAFDDAGNLTKPKERAVNKIGHYLHALSPPFAALLDDARARSKGEVSPAAVARDLGFADARCLQSMVICKQPEIGGAVPPHQDSTFLFTEPPSAVGFWYALEEATLENGCLSFLPGSHRWAPIEKRLVRKAGGAGTEIVDNEGSRFPPGDEYGEERRKKGDREEEEYVPGEVKAGDLVLIHGNLLHKSERNTSSKGRIIYTFHIIEGEGRTYDERNWLQPPKEGFTKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHL0</accession>
    <name>A0A2T4CHL0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1005334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHL0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHL0"/>
    <dbReference type="OrthoDB" id="5359231at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="671" mass="76049" checksum="72A005BF24F27C40" modified="2018-07-18" version="1">MSLCRVPSEILRLIAVSLDPDDLFNLALTSHHFEHVIDDGVICRSALENAKYSPEYRQCKAKEAGEKAIPIEEYAKALRTLVKRRRAVQMARPFHVLEVSREAVHFTYANGAVCYTTKQTSPVHQHHLRVLILKGSSVTEKSKDIPELIEESAISDFESSRPYQFRPLYHADGIVSCLYEQKKSPGNGRWLIIYSLKNGILSSHPLRSSLNIFVRNNDKYLYYGTRSELVEGKRRWSICGFNLKTLSWLPRRFILRDLVGSDIGSTICFELFGDHLYGVSSQEAAELEDAEWGSPKSRSNSYYYAFQLSLGDHPTITILPRCALWRRGATDGPIDDRWNQLQLAQDETTGQVSIFETRKEWLTSWSRRSCYRRQLLWPSCVEFTDGDANGKCRDGWNVMPPTETKLGYSVHRGDNGFCSSSFDFNNSPVRSYNTSCQAFVDVVSTTTPSSPTSKRLRLRVRSRPHESGLDLEPCQSTSSPNGVADAVMDSEGQRIRLWPADHTQQDEHRSRCSEQLWSQYIDELLNPKAYFDYIESVTDESVIVYSPKSGYSPDEPRSIVLISFDPSLHFEGLCHASSTPPSLTSTQPNVDNDPLGLRGRSSDFTKSQQGIARVRGLDLCCPRKEKREVTHASSSTTSPKSIKVDLLSERIRCRNFHTDQRSSISTKMAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHN0</accession>
    <name>A0A2T4CHN0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Map kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_45121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHN0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHN0"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="501" mass="55166" checksum="D61C23A202A7C784" modified="2018-07-18" version="1">MADPFAPRTMKRKNVKGLALTPAAPRPPPTADTSRRGSEINKDDAGKEEQLEIGIEYKLDLRPEELEVIKELGSGNGGTVSKVRHLTTGTVMARKIIHVEAKKEMRRRIVRELQIMHGCHSEHIVTFYGAFLNHNNDVIMCMEYMDVGALDRVSRVFGPIRVDVLGKIAEATLGGLTYLYIKHHIMHRDIKPSNILINSRGSIKLCDFGVSGELVNSIADTFVGTSTYMAPERIQGEKYTVKSDVWSFGLTIMELAIGKFPFNTSEHIDDADSAPAGILDLLQQIVNEPAPKLPKSDAFPSILEDMVQKCLFKEPEKRPTPQELFERDPFVQAAKRTPVDLKEWAVGLMERDNRKSHLVPQLSPSGTHELLRSSDSSPQSRNEEAPLDGPFFGDIPIAGDRLFSPRDQAATQNRSPSRNGAPTSRTGHPSLAPRNPASGYADGSHHSSSNPTTFSLPVRPAPPTSSFSREGPPKSAADEARGQSRRQVKTYGLPPNPSYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHV0</accession>
    <name>A0A2T4CHV0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_77559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHV0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="102" mass="11828" checksum="FDA66106A8BAFCEE" modified="2018-07-18" version="1">MQERGDDEGNEETRWGVSRGCDQGQPLILSSFLRVIPFFFPCSFSALLLFNKAVERFFYLFIEAEGWMGSGRDRGRNERYPDKGVYCWFSREGRPLLACINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIF5</accession>
    <name>A0A2T4CIF5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1367286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIF5"/>
    <dbReference type="STRING" id="983965.A0A2T4CIF5"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="76"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB81324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="172" mass="18008" checksum="556596346720ECD2" modified="2018-07-18" version="1">MSSPAVLSGADDAQIASTCAAIGISASEFSELRRRATAAKATAYCRYSRFREGEEVVVSLFRGAAPGTTVYVPGANVENASYPVGTCAERVALGTAVTSGIRTFRAIAVATDISPPASPCGMCRQFIREFCAMKTPIIMFDKNSDYVVMTVDQLLPMSFGPDALPPPGAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIQ0</accession>
    <name>A0A2T4CIQ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIQ0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8713" checksum="A4C211BBEC9D2C19" modified="2018-07-18" version="1">MEEQIQESQEGGGSEGRGGRRGEEEKRRKKEKKDWMQRNQARKLHVRVTSREEGRTVGFPGLDAPSTKVSDYLPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIT0</accession>
    <name>A0A2T4CIT0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TMEM14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1396641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIT0"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="10756" checksum="5008DB19409CFF6C" modified="2018-07-18" version="1">MSSNSSLSNASFVLAALTAGGGAIGYAKTGSVPSIAAGFLVGFLYGVGGYRIANGQSYGVELSLLASAVLGASAIPRAIRLRKPVPIFLSVLSTYGLLTFGSALRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJZ9</accession>
    <name>A0A2T4CJZ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isomerase YbhE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJZ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJZ9"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="392" mass="43151" checksum="51F2B3CC3EFA213E" modified="2018-07-18" version="1">MSRRLLISRPGHIYLATYSSSSSSTIPKITIDLDLPFPGNPSWLAIPPTDHTLLYAVNESGSSLHLFELDLPSNKLTQIAQRDNASKGVCHLEFNKQGTLLLGSAYEAGAIDIWNTEDPRAPQLVTTLPSKDPVVDAGRVPHAHQAVVDPTGRFFVVNDLGTDSMLVLDALRPHVPVVRRVTVESGSGPRHGVFYPGVAEEGKEEGKAATHYFLLCETRNCVEVFELRYREGDIEFTPRGSYSTFVSDGDGHGEEGVPKRGAFAAAGEIVLSRDNRHLYTSNRLTTDPTETIAHFRIITADDDDDDDEEEEGGLKLELVGETSTRGKHPRMFSLSRDGTELFVGNQEGEWAVVVLRRREDGTLEEEPVAGILMEDVVEEGDERGPMFVLEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP65</accession>
    <name>A0A2T4BP65_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ER to Golgi protein transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1387348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP65"/>
    <dbReference type="STRING" id="983965.A0A2T4BP65"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="339"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="7">
        <location>
            <begin position="883"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="962"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="674"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="846"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="970"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="996" mass="110600" checksum="7B2BDF6D532A52A0" modified="2018-07-18" version="1">MFSISSTPAKQSVGDTISVLSGRLGSATLLEDRRAAVLGLRSFAKDYPATVASGALRGLIGSLSKDAEDVDTIKIVLETLLMLFNPNKESPEASDEIALWLADEFTQRQENITLVLDFLDAPDFYSRLYSLQLLSSILTARTQRTEECVLSAPLGISRLVAALDDQREAIRNEGVNLLILLTSSSLEIQKLVAFQNAFEKLFDIIAADGSLSEGGRTVEDCLILLANLLRGNVANQSLFRESGCIGKLTEMLKGLLEAQKQEDNLAKWAQIQHNRNIYAFLSIIRLFLSPGSAETHMNQATFWRHGLSYLVLQLAFDHDVQFQIKAEALLTCGDLIRNNMPVQEAFASLMVPPPLESAAEAPSAANGQAKIYIIDGLLDLTLNVHELSAFDLRYAACQCLKAYFSNHAEVKSHFLGRAIEGYQSGRDESANILSVLLRLPGDVFISDPYRVWFAAVIAFHLLYDNPAAKAVAKGLTEGDASKGEEVVTSIQTITAHLLMRIRRDDDTRILVAYLMLLLGWLFEDLDAVNDFLAEGSNVQGLIQVISQPVRVAGELVQGLCAMLLGVVYEFSTKDSPIPRATLHSILESRLDRDGYVDRLTKLRNHPLLREFEVTPQKLMSLPDGEEVNVFFDDVFVDFFKDNFSRAIRALDKAPDIEVSVITNGTEQGISRQLVDSLRQQIEDKDRAIEEANSAKQSLEGVIKEVQEAHRRAKEDAEAASAKLAAEMRKLQGEHAATVSGLEQRLAQITQQLNAKEQHLQTQLAAKDQYLQAQLNSKDQALKAQLSQAQKAHEVEAERARQRAEAEIADLRATVSRLEVDVMKANKSKTSEVQALRKEHADALAERDSQLKKANEKAEEHEKQLTGLKEEVEKLRKEADTLREEAEKLREEEEESRTEAEKRQKEVENLQSEADKLRQEAAKSKRDLADAEKAKDSVQSELDDLLMVFGDLEEKLGKYKARLRGLGQDVSDGEDDDGDDGSEGEEESEDEDEKAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPJ9</accession>
    <name>A0A2T4BPJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1426687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="9"/>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPJ9"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000043">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="219"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="338" mass="36202" checksum="E305DCCE36802A0F" modified="2018-07-18" version="1">MSATTKNVLGKVRRMIPPMLDTFHKGQLGRVGVIGGSEDYTGAPYFSAMASARLGCDMSHVICTPAAAAVIKTYSPNLMVHPLMRQSPPGKQSSAEAKDSDSDPDQVASKIIDMLGRLHVLVVGPGLGRDPLMQATVSRVIKAARESELPVVLDADALQLVQNDPDVVRGYKYAVLTPNVVEFKRLCDALKIDVGQQNSETGKVETLAKELGGVTIIQKGYKDFISNGKVTLVSDLEGGKKRSGGQGDTLTGTVATFLGWRKAYLDGLWKDREQPALDADEMMGLAAFGGSSVTRECSRLAFLKKGRSLQASDLTDEVHSAFMALFGEVDEEADAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPT9</accession>
    <name>A0A2T4BPT9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1365970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPT9"/>
    <dbReference type="OrthoDB" id="4763424at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="297" mass="33570" checksum="7159067857394D1C" modified="2018-07-18" version="1">MGAAGGYFVMKWLPKSRSRTSATRTKKRRVEKPLLDTTSKEAVAGLKSKYMAPCACNSRQCCHTEHDTFRVLPLQSTRRTLCEEAHGEELHDEPPVSVLPSPCLDPKLPLLPLHWSVSDHLSFDKLASARRTLTSPNVRVFVPELSNKGNILTDTEARFDWFSHIYFRNGSFEQRCRVTSQMHRGSLEHYIACPHQSISVSEPTFGKKNGHQEVQAWVTARPPRCPSHPMERWVDRTGPYIHRTACRICDVDVECTIDVREGLFMRVIFTCRRGLGAGLGPSDPQWIALMTGNGQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQA8</accession>
    <name>A0A2T4BQA8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1145877</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQA8"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="541" mass="57816" checksum="230A335C856C978A" modified="2018-07-18" version="1">MSSDLTWRPLPQATSSDVPMLLVSVDIGAAAYTVRITDMANIWVESLDRKAIFMRGWSENTSIDPSDTPENMAKFLASLRSALDPTQPGHEQTSLTLSPGSSTDAGGDSLTLLVNCPLPGFQPLRWPIHLSKSPPSAIATDLVLPLLEAQFARKQEVDSLVQALQQKDAVIGKLADKLEATGTGLEHVFTSLSGRKKVSRAAAEDKVKGLAPFRQDTWVSSLKAIDDCPTNVGDLARSVFNGEGLNRRCQIQVDASPALDKWWHDLKGMAQLVHRHKQQSVPSAKKSPSPTAKSTSAEDDDFQVQPTPPHLQSKSKSSHVANADDESTADEEDLTMEPAPSEQDPQPSTGKPASRLANSGSGKSKPGSSLQDTKATGSRTTTAPVSGDDVETASEASDEDLPPSHPASSPKPASTPAPVSPRPTPKAGGLGRIGGIPNRRPADTAAAPQIKETETAEDRTSSTPPVPIRLGHIGKKADTASSKAPAADNTKRGRSTERAESPDEDEPRETSQERADRRRDELKKELERKAAAGPAKKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQQ9</accession>
    <name>A0A2T4BQQ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_23159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQQ9"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="916"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1204" mass="133625" checksum="BF4B1F674869CDC8" modified="2018-07-18" version="1">MGQEQFNHDLAAAKKLEIEGVSKVRRGDSDGEVVFTWLPNDDTEPLDIQILILDVDAYPKNSSVLIFTVSEHSSPEISSLLERLSASLANKNIQAIIETTAEKLLTKPEACANASETAIVESSEDEWEADYDDYSDDLFEIACASSKSRIPNAKETAPSVARLKKELRIAQAAGIAIGIFPPKSVRDADFYSLSLRVKKLGIPEHALEAWGLERCEYLVLLCRFPTIYLPISELMDSQLDKFKLQFRFGKCSKPKPSFDTARLAFTSPSDGGPQGEDGSCEEAADGNGSFIPLYVSNSINMLMNNHFLALLKTRRREGLSWDAALGRLQSDSGNDHSPPTASADAGAPEPSEAPVSENAIPSLSHDYALDDADNFSLPMAAMQFALRHLARCTKYCMVCHQRVEDGFEALKPYVCSNPLCNFQFLNLGLGASIEHEIVSNPYVVDILISFFAAALAFPKGLRNFPTGLNLKSIFTGNQTKEATRIAAEVCFQDKTIRFGPDLKTADINTKVGDRLMIVLNTTENLPVPTILDGNYERHACRVTKVAYELYTFEVLATFTGPLKTARLSQEVTPTQLSHPKKDWMKAMLLRYDCEIDNLDEDDQTIALAMVLREIPSVLDMRSFLLKNPGQRLSSWSRLDKPALTLLQWIISSNRSLILQNDAVPRLEKVGCALLGQADTNPNRVEGLPPLWMQFRFLQGTPERERIFTGEIATLSKSEGDAAMFPTLFAWHGSALHNWHSIIRTGLDFNKVANGRSFGNGVYMSNNFQVSLAYSRMGAHVKVTPPVRYWPNSVLKPSSAISICEVVNRCDKFVTTKPHYVVNQIEWIQCRYLFVCVEPTAEALQEPFPTKPREPCAGYVSQHPSRKLLAGPNKEVKIPLSAIVSNRQLLGHKADGALNDPEVDQPVDQQVDTDQLPEIDHESPGSDHGETDHELLLDSDDDDSVATRSSKRRSSSIDSADQRRPKLSSSEYSKKMPKENAVVSFETDFVPGSLDLDSLPRLPEPSWASTSPMALRTLNRAIKELHDIQSREDLASLGWYINFDKLDNVFHWTVELHSFEPDLPLAKDMKERGCTSIVLEFRFGSNFPYSPPFVRVIRPRFLPHMRGGGGHVTLGGAICSELLTNSGWSAVMTIEKVLLQIRLGLTDSDPPARLDSTKGINSSRDYGIGEAIEAYQRAAANHGWQIPKDLTSIGSAWTAPEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQS8</accession>
    <name>A0A2T4BQS8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1385941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQS8"/>
    <dbReference type="STRING" id="983965.A0A2T4BQS8"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="516"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="605"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1026" mass="115341" checksum="FF6D4F9156736303" modified="2018-07-18" version="1">MVEDEESKAYIYTKVSLRLTLFPSFSLSLPPQVKVTGILLSKLGACSRISYSTERTATPVDWTASDRLTPGTLVVMSPRWDYFRTKCIVATIATRSFNGRAVPDVEDGDSPFDLPRVELFFANISETLIDPIEDFVMLEAKTGYFENVRHTMLGLQHAAMYHSTICVEDDEGRVATAINPAGDTVVIPRAADGFDQSQREAFDMMSTQALSIVQGPPGTGKTFTSLVAIQGFVQTQKETRPGSRRAPIIISAQTNHALDQMLDLCLDRNVGKILRLGGQSRSEFVSRHSLFNIKSKSRFRRQDYRGLASWKRICGSIEELVETYTRDLVGAQELLEVNVITGHQYQSLVDGSPAAVQVARDEHTEDPKEISLVIGWLYSFSSQDPEEGIRAMLPGKARKPIVGRVDDTPNDDMEEEGQAVRGKAPDDAAFRLRGLYLPFDPQHTVAPTPPGCRRTGRWWQEARALVKGNPDLNKINANARPMVYYYLKTRLRDCTIKAIRKQLRAYREVCDTLRAHQLANTVHIIDCEGIDIIGCTTTGLSKYRGMLAALMPRVMLIEEAAETREASIAAAMFPSLEQLALVGDHQQLTPHVDIPFLGAAPYNFKVSMFERLVKLGLPYKTLQVQRRMIPRIREVVQTFYPMLRDHKAVKDTRKRPPVPGMGGTNLWWFQHRWPESQGTKLSYVNRREAEMLVGFMHHLMMQDVKPSQVTVLTYYSAQVELIKELIHKDDMLRFLHPVWSVRTVDGFQGEENDIIIVSLVRSPSDPMDGNSRKTVGFVEEENRAVVAMSRARRGMYVFRNAQHILGSSQRSNETWQKVFNAFATQTGDYLPLTCRTHGNLTVIKTASEWRRILEGGCLKPCNRECPNGHRCSYQCHTNSILHRNCREPCARTLFCGHKCEERCSEPCKCPRGCTPMRRFPAPAQPASSTSFDGFDPHAALQQMEPIDLRSLGLAPGQHWLELLLTRSLHERPPIQARWLPELAFPRPGAPQAEDSGETEESGETEESGESGESGESGESEETQDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR11</accession>
    <name>A0A2T4BR11_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1343500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR11"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="474" mass="52876" checksum="1108F9E0DE4F4978" modified="2018-07-18" version="1">MPDINTEKGQLAQEELLETPEWRARERKLVRKLDMTLLPVVWILYLFNYLDRNNISQARLNSFEEDLGLKNDDFNTAVSILNVGYMLAQLPSNMLITRIRPSIYLPACVAIWSCVSASTAAVTSYGGLVTVRFFLGIVEAPFFPGAFYLLSCWYTRKELALRTAVLYSGLVLATAFSGLIAAGVFSGLDGARNIAGWQWLFIIDGAGSFFAAMVAFFLLPDYIESKTGSGKWLFTKEERELAAKRMALDRVSLPEADRSVWYGVRLALKDTRTWIFVLLLCSNHTAYGFNYFFPTIVSGFHIGSQTITLVLTAPPYLFGAAVSFAVAYSSDRRNERSYHISIPMAVAAVGFIISTATLNIGARYFASFLYCSGAFAANAMVYSWAASTLNQTPEKRAAATAIINLLAQLGNIWSPYFFRPQDEPRYALAMILMMVFSFISIGCSSLLKLLLRRENVKLLREAEVSGQRITLYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR62</accession>
    <name>A0A2T4BR62_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1385732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR62"/>
    <dbReference type="STRING" id="983965.A0A2T4BR62"/>
    <dbReference type="OrthoDB" id="3499003at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31053" checksum="23BEA9A7026AAA6D" modified="2018-07-18" version="1">MGSHPQYSPDGRGGDVDRGRSRTISTGRSDSDYYIHGRGRQDSFRAAPDGGSTAPDRRSVVPSSGTFYREPTPERPPQTRDTNLDASSTTNILQKAGEFYDYQYDHVAPPAPIPAATICGVKARLFWLLLGAVALLVVIAVAVGIGVGVGGLHKSSAETSPGTMPSQTSHTKASAPTPTSRSKTAGAPEPTSTHLLSCPQGNGTRYDVPNSHKTFQLVCDIDYSGAGEATDVASLYTTDMEACITNCASFIGCTGCGWGVIPGDAGSLHRCWLKGSLGKTHQSKPGWYFAILQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRH1</accession>
    <name>A0A2T4BRH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1405938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRH1"/>
    <dbReference type="STRING" id="983965.A0A2T4BRH1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="539" mass="60404" checksum="6CCD9D4858F55D0C" modified="2018-07-18" version="1">MGEERRIVVSIDFGTTFSGVAWAETTQPDVQHVLSDWPSLGSSRNSPKVPTELRKIATGWQWGFQIPKAAKRNRFFKLRLDEPSDTKADGESAQELTRVFLTCLYAHFISVLESRLSPSVVQSTPMDVVVTVPAIWSNNAKQDTENAASLAGFGGDKNIKLISEPVSLAIKYLSPSVLQTGRRFVVCDAGGGTVDLITYEVAKVQPLQMREVTEGTGGKCGSSMLNMRFRRYLRQAHGDKYWTDERLVLALSDFESFKKDFSPRGEPLTLKVDSSLGLRRNRFTIPQDDMTIKIWDPIMRDIICLINEQISMADDDVAAVVLVGGFGQNRYLKSRVRDAIIPRTRVLQPENGVTAVVKGAVIYGLGNYQPAMAPVGISSRVARRSYGTCLLAKYDPSKHDRNEAFWSEKEEEWVVIEMCWFIRKGQSYPEGKPSKIEYQCDIPVFMGHKPQADIEIFSNDDDREAPIHLSGTTKRVATLFLDLHKIPKSAKSAAKKRKLGWHRYYCLTGVIEASYGSAMITYTVKLGGVTHDVIRVRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS13</accession>
    <name>A0A2T4BS13_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1473044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS13"/>
    <dbReference type="STRING" id="983965.A0A2T4BS13"/>
    <dbReference type="OrthoDB" id="4900553at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="234" mass="25211" checksum="11DB7B53D1E6A303" modified="2018-07-18" version="1">MEECAAMDYLLTLRGHTDAVSSVAFSQDAKLTVSGSSDGTIKVWNSATGECQTTVEALDDISNSGRVDHTGHIRSVVISKDSQYLVSASSQAKVEVWNPNQCHRTLQGHHGSVDSVAFSHDSKFIVSGSNDNTIKIWNALTGKCQQTLHGHSGGVKSVAFSHDARMVCSWSSDSTIKLWGATSGRCLQTVQVHGSEVVSVAFSHDSKRMVSGSKDGTIRLWDISLLLTMSKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS24</accession>
    <name>A0A2T4BS24_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1395109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS24"/>
    <dbReference type="STRING" id="983965.A0A2T4BS24"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000614">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="754"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="873"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="954" mass="105710" checksum="F5F94DD6C0DCE5CB" modified="2018-07-18" version="1">MDGQPQPKPAPYTHLSQLSSLPLRTANSTPTTSPGLYSPVARHGHMPNSSVSETNSPAPMFESPYLHPLQTHRVRETHKALIDSDVNTGRKSINQYEVIEEIGRGMHGKVKLARNLETGENVAIKIIPRFSKKRRLGKVTAMSPQDKTKKEIAILKLARSAFRDTVLGLEYLHYQGVVHRDIKPANLLWSKDHRVKISDFGVSYFGRPIRDGEPDDLVSESEAKDFDDDLELSKTVGTPAFFAPELCYTDPDQAQPKISEQIDVWSLGVTLYCLIYARIPFLAEDEFQMFRKIATEEVYIPRRRLMPVDPSTSPAVTSLYKRQNTRPYRDDNDVEYEDVDNLLYDLLRQMLTKNPEKRIRLKDIKKHPWVLQGLPNPRAWLEETDPARPSSGRKIQVDERDLSSAVVPLTFLERARSVVRKAVGRVMHPLVDRSESRSRRRAASSVASSGGDSMPKPTLPPAPATNPPTPYLDRRRSLRPDDYFPPVPERSSPPKMERHSSDFVSAHSGVEAVAYDPMATVLPPLTTPSGVTRGRSHSELDEAATSNFRCDPNLGSGRNSGTLRARNYGQFLPLTPHTVPPTPSYDRNPPYRPELPSARSELSALRVDSMRSPSPHRGLFASHDKRATPSVALNTAVAPGNIPGLRSTRSMRSVDLGRNRYSHALSSSPLSSSPQSIPTQSYHQHRHLQSDPNFHQRYQERPITAHRVDNGGDGRSPPSRTPATMSPEPVYTGSYVSEDGSADMGSQWSRIAHQDWQSDAPSRRGTMDMAKTASTDSMDHLGTPLTSPSETASPVTTCPPANSASQRMLVFQSDPSLPALLSGASSVSADLEGELLQRPGTVDPQALLQTKDSLTPPALVFDNSSSVEGVPLRVKIDGSGPTSDPRGASQQQHRKQEEDDNDDDSDDGLLLMAKSKKRPPVTTRHRPFEARRRDTNLSNISTASDETARRVNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSG9</accession>
    <name>A0A2T4BSG9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_366467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSG9"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="537" mass="56499" checksum="5B6C150B60658BBE" modified="2018-07-18" version="1">MATKVLTEPPSVALQPVKAHGSPDAASADEALSDPSTGSSPAAPAADDTKTAIVHSKWRATLVVAQLLGLNLFSSFCNGVVVVGLPAMAASLHIDEGLLVWPTSVFYLTAGSCLLLAGSITDVVGTKTMSLIGAFAAAVSAMACGLAQSGGQLIAFRALQGITNAIIVPSSVSIVSTGLEEGRPRNLGFACLGFAGPIGFSLGLVLGGVFADSTGWRAAFYLAAATTFALFLAGIWVLPKNVVRPGKSVWFRTLTEIDIVGAIIGTASLVMLSYVLAVLSADIHSIHKASTIALLVVSAVLIPAFIGWMQYQEKHQRNALIPNSLWKNWVFTSCCLMVLFTTAVCNCMELYSSLFFQQVQRHSALHASLQILPSLISGALTNISTGIFVNRMPVMWSVLISSTISAVAPLLMALIQPEWPYWYDAFFAQILTPLSCDILFTVGLLVVSDVFPAHMQALSGAVFNTCAQLGTAIGLTVTSLIATSVTNASSDADKESPGALMDGYRAVFWTMFAAMALTCVLSVLGLRTVKQLGVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTJ6</accession>
    <name>A0A2T4BTJ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1394857</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTJ6"/>
    <dbReference type="STRING" id="983965.A0A2T4BTJ6"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB72566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="105" mass="11309" checksum="683753A9C3D2AA20" modified="2018-07-18" version="1">MASGYGMHGGVGRCFPFWQEVMACYVVNTSASDDSGKKKCSPVLEDYYECLHHKKEHARALALQAAYARAQSATARDDAPSASQIRNLGLLGKTEDTKAVLGQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTP7</accession>
    <name>A0A2T4BTP7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1405048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTP7"/>
    <dbReference type="STRING" id="983965.A0A2T4BTP7"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="3">
        <location>
            <begin position="406"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="886" mass="97759" checksum="2329055F8C36CF7F" modified="2018-07-18" version="1">MLLSRTRSNAAGRLAIDDGLKKQVTSGAVAEDGRFELCFHDDAGSLATWCKNLQETSKRMQTNPCSGPAICRRKSTGGFCPPLNIAMLIVGSRGDVQPFIPIAQLLSKPPYGHRVRICTHPAFKDFVESQGVEFFNIGGDPEALMSYMVRNPGLVPSRKSVRAGDIGKRRAEMWEIINRAWRGCIEAGDGMGDPVRATDVENVEDLFLADAIIANPPSIAHIHCAEKLGIPLHMVFTMPFSPTTAFPHPLASMNYSGADAKTANYLSFIMMELLMWQGLGDLINKFRRQKLGLDPISVMWGFQLLSRLRVPYTYLWPESLIPKPPDWGKHIEVVGYSFLPLAKSYKPPPELTAFLEKGPKPIYIGFGSIVVEDPDAFSELLFKAVKIAGVRAIISRGWSGVGDKCRITEDVHLIDNCPHDWLFQHVSVVVHHGGAGTTAAGIAAGRPTVIVPFFGDQPFWGQMIARAGAGPDPIPFKSLTAENLAESISVALMPSVQEAAKRLAEDIADENGAEATAKSFQDQIGLDQFECEICPGRLATHRHKKTGTRLSGLAVACLVDRGLIQPPELELIRRKNWYVDEGAEHPLVGLAAAFTGPMGDVATATFDYSHALRYRPKHTKAEGRRPSWIDPWAADKITIGSVGSNGASPNRRINPTTFSTKEMELYAHKVARKSLKTNNADIDTLIRQPSLYDKQKAAWHARERGRNGRLFYITRATGRYAVELTKVGLKAPVAFFYNIANGFHNYPSCGYAGVEVRRRDQIIDFETGLVAATKEFTLGIWDAFSGVVIFPYKSVHEEGAKGLGKGLWRGSKGFFSNLGASAFGLPGYTLKGVEKELQKHHLTNCKAEMILIRLRQGIEAFRRATPQERDEVVRRWKARSCSRKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUP0</accession>
    <name>A0A2T4BUP0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1340190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUP0"/>
    <dbReference type="STRING" id="983965.A0A2T4BUP0"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="22670" checksum="0722968082D1DD2C" modified="2018-07-18" version="1">MLLAEDPATLIHHTINNFNIQPDKLAVSRISESLSTLQQARELHLRDSDATLKKLARQLNTINAQHDELASSHSSADHASTIARLDTHKFRIAKAASDAEMEAERLAQQAADLAARLQELELQGVDGSEEGRRRDPVDDEVLLRLKVYRSLGIEIERDDKDGEWARAVVRNDRRGDVHVVNLDKKFSRYFYANYFWQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV86</accession>
    <name>A0A2T4BV86_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NIC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1362426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV86"/>
    <dbReference type="STRING" id="983965.A0A2T4BV86"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1126" mass="123111" checksum="F15E45CB62CBA120" modified="2018-07-18" version="1">MSLFGQSTGTSLFSQQQQQQQGTTTPTPSTGGGLFGGGGGLFGGGQQQQQKPGGLFGQAQAQQSTPQTGGGLFGSAATTQPSSGGLFGQTGQNQQTSTTGGGLFGNQQNATQQQKPSLFGASTLGGGTTAAKPSLFGATTTAAAPAPQTSGAPFSSTLLGGGQTLAAQNTNATTSAAQPAGAYFDSLFAKTMKAGVVNSNMEDLPSLELGLGDLRHRLRKLQSKQTERAEGKAHYLLAASGVDPSTAAKDLGLLDLQGARTERPAHGFAQADVDVETYLSNLQTKTTLSMIQDGLERSLRDFDNFLEDNVAMEWDAQRKRVYQHFGIKPRETSTTAGREAQGGFGRSRRKSQANIPRDSRSSAFGSSAFQRSVIGAPSRIGAHQPEFADVDRSADGAAKSRNEDQALRERQSKLAEKVRSLNSSRLLGRPYPLLAELAEVEQKSHEPHAPHVVEAYRAMIEIVGEDAEAETALSSKTAKERQFAEMYLDENPNSQRSVDMRRRILSGANAFLEKQFLREVESLIAKHPHEAKLGGLPDITSKIKAYIRLRSARKDLVPDNTELQQIHGEYVWAIVFYLLRSGHVNEAAKYVNDNSNHFRGIDRTFSTYLNNYAASEDRRITNRKLLDRCTNEYIQRSRNAPENTIDPFRMACYKVIGRIELNNRNLDGLNTDINDWIWLQFNLAREGDKALEMAGESYGLADLQASIREIGQKHFPKSPSDDNNGSCGMYFYLQVLSGMFEDAIAYLYPFSYVDAVHFGLALEFYGLLRPSDPMSASNDLRTHSIKGLPQINFGRMIGYYTRDFRAADVVSAVDYLTLICLNSDLEGEAGARHSSLCHEALRELVLETREFSKLIGDIRPDGRRILGVIEGRGPLIGLDGQDDFVNTVTLQAASFADESGRTTDSVLLYHLAGEYDAVVAIVSRALSEAISLEIGEDPMRLMPVKPRAGGGHEAEQGGSLSLAAIDDPVELAKTMMTMYERDAMFYRNIQDQNKVACRVLLEMSDIKSLVEASQWAQCLDKIRGLDILPLEAGGDASTIRAYASKFSSLSQPVSINVPNLIMWTIISCVRQREQLVNGQFSGNEGTRKMMVEQLKQMILDLTTYTSQLRYRFPPHLHEALARASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW52</accession>
    <name>A0A2T4BW52_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1404519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW52"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015642554" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33064" checksum="D7E5F1D8A0217C4F" modified="2018-07-18" version="1">MHAIALLGAAAALFGPATAMPKATPEPHQAAALDLARRANIAPRADPTAPWVTVGDEGKPVKTITPSMTTISGTPTLVSVAPHDITASVYTWTTWGSITTSTGRPPNPTATSKDGEGLRLPLKHAAQPAELRAKGHKTNNVTITLQVAPRGSKDSNSSLPLHVALQDPALPSNPAPQVPKGRTLSIALPVALGGVVFIVVGVFLWNRSARRIHLGSIMGRSRHGYSGRKARRGNMFRGQKDAASIQLHNADDHLSDGEYHDAPISGRRDSEALGSLAGTPVNESFDGQGTWGGARNAFRDELDRQHQERRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW92</accession>
    <name>A0A2T4BW92_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1066401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW92"/>
    <dbReference type="OrthoDB" id="10623136at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16804" checksum="93EB5558D89D0B95" modified="2018-07-18" version="1">MAEPIRRWLRLALGSKPGSPRGREPGGGVEHGGGQIVSPCARSFNSLQTLPWMLQSYLSKISLALCLSVQVKGRKHRVAGTKCKHYGCRSVSGYARRPRQRRRESSSRDDKSLACLYAPPPKHDVILKEQPRHGCMAPFQSVGLQVQTTLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWM7</accession>
    <name>A0A2T4BWM7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylcrotonoyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_7318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWM7"/>
    <dbReference type="STRING" id="983965.A0A2T4BWM7"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6381" checksum="158E9989E1532C15" modified="2018-07-18" version="1" fragment="single">ARIERESEATYSSARLWDDGIIPPQHTRQYLGLGLRAAMGGRNEVKAGDTKFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXH2</accession>
    <name>A0A2T4BXH2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1440923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXH2"/>
    <dbReference type="STRING" id="983965.A0A2T4BXH2"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHexose_mutarotase"/>
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        <property type="entry name" value="Galactose mutarotase-like"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="225"/>
        </location>
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        <location>
            <position position="183"/>
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            <position position="78"/>
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        <ligand>
            <name>substrate</name>
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            <position position="102"/>
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        <ligand>
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            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="315" mass="34062" checksum="63725AA0F1E9D87F" modified="2018-07-18" version="1">MVQRPNKPSALAATPGLQPQAQVTISDDSSRVTAVLPTGESIEVLLYGATVLSWKDAAGDEKLWLSEGAKLDGTKAVRGGIPLVFPVFGTAPDHEATSKLPQHGFARNSRWEFLGKSSSEGSSSGVKLDFGLSSENLDDAARQLWPYKFGLLYSVTLAPESLGTALVVTNEGDEPFEFQTLLHTYFRVSDIASVQVLGLEDSPYHDKVDGVKNKTQSSDPVTFSGETDRVYTPVKGPGHPVVITEAGVAKFRVMRDNLDDVVVWNPWVDKAAGMADFEPKDGWKKMVCVEAGAVSAWQKLEKGDAFEGAQTVYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXM9</accession>
    <name>A0A2T4BXM9_TRILO</name>
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        <submittedName>
            <fullName evidence="4">G-protein signaling regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_7015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
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        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
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            <begin position="282"/>
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        </location>
    </feature>
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            <end position="357"/>
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    </feature>
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            <begin position="177"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="362" mass="41057" checksum="886985E5FC37AE78" modified="2018-07-18" version="1">MDDPRDTTASTTPQPDMTRNRLPTLFEVLSRRTLPPVDLFSFYIYMRDQQRSVDYLDFWLDVAQHMSLCRHYVRELRRSVLIATPDLEKGSKRSSQILDLGDMDSRAAGPSMYGTEKERDQDAQMSAFLREDASHESPQTQTASNQTKPSPFSLSRDPTDSNSPAHTVARADIRASAEKILYTFLMPGAEREITLPGSITQDVTASIEEYGRDDPEVFDVAKDYVFQAMERDAFPGFLRMKALGNLIPPTLVMRLIVGLVSMFGAFWASFILIFLDKSRATRCWLILPFTIGVYFLASYQYSLDPILALIGFSEYTPFNFSRIREPYVRRLLAKRAVMVLAVTLLIDAGLCVLFILVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXP8</accession>
    <name>A0A2T4BXP8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1338047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXP8"/>
    <dbReference type="STRING" id="983965.A0A2T4BXP8"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="106"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="549" mass="60780" checksum="C1955E75EBB95F8C" modified="2018-07-18" version="1">MAPPSPRRSSRARTLASHSQQSLSTTNFTRLERHTRSLNRPQSGKSTPSASVSSDPLDDIDDTLLGRRRKRGHDEEQYKGSRGEALDMSNDPDSLQEEEDEAVRCICGCEDYPGRPPVDGSDAQFLASIELSEDVTGFFVQCDICKVWQHGACVGIFSAESSPDEYFCEQCRKDLHKIHTANNGQKYSKYLPLSRPARTASQATSIAKDGARSPRLGSSKSIRSQSTSQISKRRSTMNSRDAAYDDEQLRRAIEASKEEVTQDGAESITRRTKRGRSNSEDNNVAIKRQRTNSQSPSPPPKPIDATSLENTDDESNGRSGPKRPRVFKGTEKSDKEEKDRLRQETANKRKGRADRRRTEEINPPSSKVPATKSAEPTTLAEPAPLPSPVPGTPPMSNSSTANAPKRSSRSNHRKGKGKNQYTKDRNTDMEHSPARSVSRDNNATSSSHAKNTSDHKSSSKAKLGIAGRMSMLDMKRRVAAIMDFISRTQVDLAAEATLDRSNNSTDLDSHDTTASPADTPMSRDFKDLTCIEMMDVLTRDMVKWQNQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXS8</accession>
    <name>A0A2T4BXS8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_126288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXS8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="56" mass="6287" checksum="DF6A01E443194839" modified="2018-07-18" version="1">MLLSWLSVPSVEVEFQGGWWWYYCSPQHLSSKQWTALVFPCKAAATRVGGGNGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXT4</accession>
    <name>A0A2T4BXT4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1058805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXT4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015531692" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15370" checksum="FB427DF6B7037110" modified="2018-07-18" version="1">MFLTPCAYLLCCQVVQCTMLHIITTSCSYLGRYRRNPNPLTVPEPSDIHATLPKARYSLFQARHTPALQQPCLFGILVSIFSFCDPESSFRLLLKRKRPCSPPAYLTWSVRSERDLRRRLTLATGYGEDRLTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYC8</accession>
    <name>A0A2T4BYC8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1403692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYC8"/>
    <dbReference type="STRING" id="983965.A0A2T4BYC8"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="111" mass="12337" checksum="36D305B4334C4B62" modified="2018-07-18" version="1">MADAPYDPYVPKAGADQSGGQSRTQALQGEIDATVQVMRNNIQNVAQRGDRLDVLQDKTDNLAESAQGFRRGANRVRKQMWWKDMKMRVCIVVGIIILLVIIIVPSVVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYT2</accession>
    <name>A0A2T4BYT2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sedlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1440621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYT2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYT2"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="14024" checksum="5D12BC23BF09AF93" modified="2018-07-18" version="1">MSAAIPSVACLGVIGRNNNPLHISIFPAAAALGTGGGAAMSASSSSPSGAGGGPSTLASSSAAAATARSAVGSVGAGLRDAELKPVFRAMQSAYVRLLQNPFYDPDEHAPLGGKGGKRITSKKFGDAMKRIGEAWTPGVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYV4</accession>
    <name>A0A2T4BYV4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1439992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYV4"/>
    <dbReference type="STRING" id="983965.A0A2T4BYV4"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="612"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="606"/>
        </location>
    </feature>
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            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
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            <begin position="433"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="742" mass="76408" checksum="7F3FF96B015B2889" modified="2018-07-18" version="1">MTNQPPESIGPNWPPHRLSAVRRRALVLVGLFVLSLSATLFVRLVTIEVSTLEQQTLVKRQFQLGGFLGSVFREVIGDRPIVTPTVAQPTKQDGTASSWTASVIMETPEATNILSDAPKASIQGTAMSNQSGSGADKLLETLAAAVKEAIMKSTQPPSSVPNHRQKSALSDMIASQSNADSAPLGSSISSPHTPHPTPSGGILGGLSGDGLELRILNARAIAEASSAKPSAGSPSFLSDLSKIVAEISDIDPIAAAKLTDTVLEALHVNSSAIASAVPKVASQASVSAAELLPLVIPAVAQAMDQPLPQVPSVSSLDMAETLDKVLQQGTTVINDLSKGMQDITDPSLLGVLNELAMIVGAVSNYLEKPLCAVDRVVDKTSFEAVIPCDSAEAHSLNSTGQLTTLAAPMLADPAPHSSTSGTSITMGLPPPYSSGNQAPSPEQASPSHSAAEGPSKTSSPSPANGGTGNGPVPDGGAPAGTPSLPSACPSCPSCEECTAKICSVEGPGGTSDDQPPDASIGPCPGRGYRCDDCLDGWFCPPQETPAQVVPCGLGWPCFHCSEGWFCTPNATPGPTSPPSAAAEPSSKDTGRPGTGSAPAPTALPSDGDLPAGWNHLGCYQDEISRVLLNIKHISYVQGDMSSKVCIDHCQSGGHEFAGTENGNECWCGTSLRDDAVRIPDSQCDKPCGGQSTENCGGSWTMDVFSCSDEAGSRAPDKPTGGFMYRLLSTFRGNNRGTVHRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ29</accession>
    <name>A0A2T4BZ29_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
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            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="205" mass="23026" checksum="5025ACF1E1F814F4" modified="2018-07-18" version="1">MDPCRSESPSQPRKQTYNNFGTYPSSPGMDSDSGACHMASQFLQIFKESGLQRQLEDGWGQRYTGGRGPGSASAHNEDVTQGCQFDPKSLRSSKTPSSLDPRKHREEGNTRSRKSKRSRSDDVKEEDEDEDDIEVIPVVQQGSSRPYSPVHDCQPTVSREDHATTGYKVNRDGYRGRGYLSELDTELDALRKHLLQRANSPRSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZB4</accession>
    <name>A0A2T4BZB4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1031046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZB4"/>
    <dbReference type="STRING" id="983965.A0A2T4BZB4"/>
    <dbReference type="OrthoDB" id="4499262at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
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        </location>
    </feature>
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        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
            <begin position="361"/>
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        </location>
    </feature>
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        <location>
            <begin position="364"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="44344" checksum="12F7420B0007A64C" modified="2018-07-18" version="1">MMRLLLVLPLTGLASASAARERYAAVQLVPDGLTPRYSVDRSHPLFKREGSCGDDAHSCLDIGHGDRCCNNESYCYINSSNEPKCCAIGQPCTSDNPCPATAFRCSVTRTITLTTSRTATTTSSSPNNNRAVTTTVLTGCCGRACPQTSLYLCAPSLGGNCCPYDASCQAGGHCVSTKTSPPPGLTPVAGNNGGESQGCTTSQFRCPDGNGCCDNGQACTSFAGAGYCSSATGGPTSTLAAAGGDSSSSSSSSSSSSGKTSLSAGAEAGIAVAAVVGGGLLVAAAAWFYLTNRRARRNSPYPNAAAAAAAAAAAAAQRWEMVSSVTPSGADAGTPFRSPSSAPDHHQHYPVELGTDRELLSEAPGSDVPSPGSGVSAAAFGELRTPETLDGRFELHGSEGNWPMPSPASPLPSPPLQGGSPLPSPPLPDGNPSLNQDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZH8</accession>
    <name>A0A2T4BZH8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1440113</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZH8"/>
    <dbReference type="STRING" id="983965.A0A2T4BZH8"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48171">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48171:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="60391" checksum="C250317E60B61B4C" modified="2018-07-18" version="1">MILTVPLAIIIFVATYLPVILDPTDRNPESRARDRLWVSSSPYFWDRQVCRWFSLCGLHHLRRDPAVLPPLEDEPEDELRLELRKRMDRTWEEDAELNAPEADSRRSKRSDKKRNPQERRKILREVPSYVFKHAPLVHLYSGEQFWPSDIREHIEHMIVTVDHKRVNLTEKVSLHNLQALNKYEKRMVTLHSLEDVESRPKWLHSHDNLPVPFDDPDASTPPSLGSGKKAHTEPDTWFDVDKKHPVHRISDPRNKNVPSYAPTPTPGKEQQRIVPRGHKPDPDGYSKAPATLVLVDKGSGIIDAFWFFFYSYNLGQTVLGLRFGNHVGDWEHCMVRFQNGVPRGIFFSEHEGGQAYAWEAVEKRGDRPVIYSAVGSHAMYALPGSHPYVLPFKLLKDVTDKGPLWDPALNNYAYFYDYTREDPKDTIEHDDGIAEKGLLHDTHSFTPAASNPDAPTTWLHFQGRWGDEVYTLADPRQWRLFGQYHYVTGPAGPKFKNLERQTLCPARNCRLLYEVDPKGTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZS4</accession>
    <name>A0A2T4BZS4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_104724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZS4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="10892" checksum="49CC27169F0B9550" modified="2018-07-18" version="1">MMMRPDGDRIVSARFSKWRLTLVPGVALAQKSGPRSISNGSIGVASSDVRESLSVIRRTAAVDPASLPCARTLRVIPVRHVDSSKQQNNISLPPMVADSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZU2</accession>
    <name>A0A2T4BZU2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1471344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZU2"/>
    <dbReference type="STRING" id="983965.A0A2T4BZU2"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="62"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="477" mass="51452" checksum="142F875E93C6D67A" modified="2018-07-18" version="1">MSPTSILLRNATILVPGPTGNKPVLSLRNHSLLIEGNKISHIAARIDAPSDKTQVIDCTGKIVSPGFIDTHHHVWQTQLKGRHADHTLMEYVPTGNMQSYNYTPEDIFWGELGGCLEALNAGTTTVVDHAHMNYSPAHNTNALAATISSGIRSTFCYAPTTRLISNGPYGENGRVRIGLAFDALFLPKETVTDLYHRCRRAGAKVITTHYVRGAVFGQHSIVDTLEAHSLLAPDVLLSHATNLTPSDARKLSAASAHISSTPDTELQRGLGNPVCFHDDDIQSISSLGVDCHSNNGASLVNQMRLGLQAERGIRNAALIEQGKAPRHLTLSVHDAFHLGTLGGARAIGMEDQLGSLEEGKLADIVIFDGLTPGMVCAAEEDPVAAIVLHSSIACIETVIVDGRIVKQRGDLVPVDLDLSMSDLKPAETRLEWSDVARELLKSRQRVIEAGKKSWGGDMDKAIDSLTKAFHIEPNNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZW5</accession>
    <name>A0A2T4BZW5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1440199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZW5"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF3">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015736793" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="25942" checksum="EBFB53BA5BFF4462" modified="2018-07-18" version="1">MLAQSLLVLASAALSYASPVTCRAPMPDPVLPTTGGATELPPVPSNLELKLIALGLGIQNYSCPSIGSSAASTGALAMFYDISALYPSSGPRALSLEKFNQLPAFALNHHPIPLNFNDSSEGRVTADGPGASLSRPFTRAAPLDLGEEVGKLPFLGHHFFNTDGAPTFILARGKFNVVAAKKASVPAPGSADPGPAGTGAVAWLALDGNQSSRGATLVYRVETAGGNSHGCAKAAGQDSTSYAAQYWFYGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0H7</accession>
    <name>A0A2T4C0H7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0H7"/>
    <dbReference type="OrthoDB" id="4897011at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015647816" evidence="1">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="16163" checksum="555329E700FCF955" modified="2018-07-18" version="1">MVSLKSTVVLALGYASSVLAVAIEYNKGARPAIPVPCDGDELALASPPNNATAGTEHRSLDERQSCGWSGTFYEQTSCSSAGSQFTQCSGGAGCVLTNSVLAFGFQSIKAYDLSCDLFIWNGDCSSGYSWYIPRNSPTGICWGGFGTGHGYSVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1D6</accession>
    <name>A0A2T4C1D6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1379573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C1D6"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000507">
        <property type="entry name" value="Pre-mRNA-splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="7">
        <location>
            <begin position="507"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="8">
        <location>
            <begin position="719"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="827"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1394"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1403"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1438" mass="162916" checksum="86FC2443E608B5A3" modified="2018-07-18" version="1">MPTAKRTRGAAGRAAAAREPPKDTTDGRPTPAEVEEQEHPFVQLARQHWLKPSKKTAKVKVKNDVVKQGIWDVLEQDGFSYKLLLLLESLQTLESYLWPGYSEQASNYHVLILALICNVKRREHLETWKIFEERPDDFSSLFRRILSMTLDRTLSTTLRTQLLCFLIHAFQSLDCTIVRKECAPLVSIGIWHNLHSEKRQEAYLDSTPHLRKAWRAAQKRYDAADEATKARLRFERSWLYTLVLDFINQLYDEGKSDQTLLYCERFTEFICDLQSQLPTRRYVNALVQDLHLTPLMRLSPLYNDAGSALLRDLCALLSHYTFFAIDDQSGIQLSRTEAFDRHCTLLGKLQRIALKHFKEKLTILALSNYGSIDKREELVSHLEPLTDDELLNLVNLLDLRSSYPEGLSLVIDRKFLIEFLLTTFERKKMFQETAQRISIVPTEDSLFDDNFQRADSYDGSRPLALPKLNLQYLSVGDFLWRALVLYRCESFYGIRKDIEAAMRRLRPESTRPGETHFAGFSKMAMPISKPTILEVVPALVGDDKPSMVRAEVSFDARRLGDNVRREWDTLRPGDVVFLLAVQPPASGQASANGGSQPQSDAEKAGVLVVRTAEVLQVTDDRGRHARDKAERLDQKRRILLKLDSASYAQDAEQAAAGKPDVYAGINLLLRRNKRENNFKPVLDAIRTLVLSEMPLPSWLHEVFLGYGDPAGAHYKNLPNRLKTIDYRDTFLGWQHLVESLPGKTVEPDDDVTGSFGPPYVLEAVDRVEEPRGGKPSKKRRRDAEPALLSEVEAFKVSTYKPPNNGPYPVDAPKLNTVRFTPAQVEAIMSGTQLGLTVIVGPPGTGKTDVATQIINNIYHNFPDQKTLLIAHSNQALNQLFAKIIALDIDERHLLRLGHGEEELDTEGSFSKYGRVESFLDNRARFLFEVKKLAASLGAPGAHENSAETAGYFNVSYVEPAWAKFLKVAESDSSSASDIVQSFPFHAYFADAPQPLFPPEADRAQVLDIAQGCYRHISKIFSELADIRPFEILRREKDKANYLLTNEARIVAMTTTHAAMRRGEIAALGFHYDNVVMEEAAQITEIETFIPMAMQKPVNGQLPLQRVVLCGDHFQNSPVIQSLAFRHYANLEQSLFSRLVRLGVPTVTLDQQGRARPSIAKLYAWRYPKLDNLPDVLSNPEFLRANAGFKYDFQFINVPNYKGRGETEPTPHFIQNLGEAEYAVAIYQYMRLLGYPAEKISILTTYAGQRALVKDVLAHRCASSPIFGLPKAVATVDKYQGEQNDYIILSLTRTSRVGYLRDVRRMTVAFSRARLGLYVLGRREVFEACPELRPAFDVLLQRPDKLMLVTGELWPTERPSTEEEAVVEGEVAMEGVEHIGQYVYEMSMTKMKQLQEEQGVPMEDTIDEGEEEMQAGYFDEEEEKVLEPDILEVREGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1D9</accession>
    <name>A0A2T4C1D9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1273811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1D9"/>
    <dbReference type="STRING" id="983965.A0A2T4C1D9"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000224">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="165"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="291"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="463" mass="50174" checksum="9292FDA62838A746" modified="2018-07-18" version="1">MADTGAVPTSAQPGASAAQNGQGNPTHLPPPPLHIPQNTNPIPTAITSPRSGVDAGGILSPTTGFRRAAPEPNKRALYVGGLDQRVTEDVLRQIFETTGHVQNVKIIPDKNAKGYNYGFVEYDDPGAAERAMQTLNGRRVHQSEIRVNWAYQSNTTSKEDTSNHFHIFVGDLSNEVNDDILMQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRDRPDAEKALSSMDGEWLGSRAIRCNWANQKGQPSMAQQQAMQAMGMTPTTPFGHHQFPAHGVASYEMILAQTPNWQTTCYVGNLTPYTTPNDVVPLFQNFGFVMESRFQADRGFAFIKMDSHENAAMAICQMNGYNVNGRPLKCSWGKDKAPNSGSFDPQQPYSPQTSQAPGFPGTPTYYPQYGAQYNGQQGNFGGPQAGSPAGYSGSPMGYGGPQSAGGYGRGHQGPNAQWNQNQGQNFNNGFGGYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1J9</accession>
    <name>A0A2T4C1J9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1379707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1J9"/>
    <dbReference type="STRING" id="983965.A0A2T4C1J9"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015549579" description="Integral membrane protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="182"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61603" checksum="5D302A80C5ECC39D" modified="2018-07-18" version="1">MRALLGLLALGMSLIGARALEVPMNEKEDSRQYCTGMYSRTSWGGPVDPFILVKFLNDTAAQGDDPIASLVIFEWRDSEFIGIPDPDIQATRLALCDDGMVKQGICNSTNKGEFVLAPNATEKSHTLILSKAVHLNNPTPINYPIKKTGYYCVITEGFNIEKYNAVVEFRNAYGELPATQIPKLPFYGGMSILYALVTVFWAFLYYQHRHDILAVQNYITAILIFLAIEMLLTWGFYDYQNHHGTANVGSKVYLIVVAILNAARNSFSFFLLLIVCMGYGVVKPTLGRTMIYVRWLAAAHFVFGIVYAVTSLLVSPESAGPFVLLIVLPLAGTLTAFYVWTLNSLSFTLKDLRERKQHVKEGMYKKLWWAILISVLVIFAFFFFNSITFASVNDPDFVPFHWKTRWFILDGWLNIVYFADVAWVAYIWRPTANNRRFAMSDEIAQDDDGNFEIGDIGMPDDSDDEEAQIGNNKPSANFGQESGLTGAGLAQAGSSRPAPNGAQSQATARSVPRESLDGETIFAVGEDGDKASDSEAESEADSNDEDAKLVNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2B6</accession>
    <name>A0A2T4C2B6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_5231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2B6"/>
    <dbReference type="STRING" id="983965.A0A2T4C2B6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="144" mass="15256" checksum="FEB789D6B54A0EEE" modified="2018-07-18" version="1" fragment="single">MSTPTTAQVAITLPHYRYLHHPPSYSSNYRTTTTANALLPPTAAVDHQPALQTPARPPSYYHHHPPAANAGYSLTDGVAQPSQSAPRPPPYGHYSHHDANSSATARLDDSYASAMPTSSTNTSGAVPAPARTAVEDQPSSSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2S5</accession>
    <name>A0A2T4C2S5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1402363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PTB75825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C2S5"/>
    <dbReference type="OrthoDB" id="2543597at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000075">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8715" checksum="AA95CC54D05AACD8" modified="2018-07-18" version="1">MVAGKKPYPKATLKKIVKAHSGMNVRKNTDITIYLNYVLFMNRLIKEAAIHAKQSGERGLTARSVRKATRDALAKFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C320</accession>
    <name>A0A2T4C320_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1423036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C320"/>
    <dbReference type="STRING" id="983965.A0A2T4C320"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="698"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="905" mass="101195" checksum="870E50AB70FA1D8D" modified="2018-07-18" version="1">MANVNKPVNIKKKEEDINRKLQIYGIINAFKNGKTPSNEQIDVALNSFLQSRAFSRPSDKLSDEGKVLVEDAKEVVKLAKQLLLSKNDGNLIQDFIWQTTQYDTQNLQAPNTPVTKDTAARHKDEALEGLRTLGTLLITNGQFRKLLKDASVLVRDMVGDGATSVAERVRPSDEELHRMDEPAPDNTWHEKPELSKEALKNQAKDIYKGDPKKDAKDVASAATGNALPQGGAASHLGGAPQNGGISQYGAGPQYGMAPQAGGIPQSVHPQGVTAEGTQINPSTGLNTNQANLGSDFNNNNQGLSSGPNTNRVNPSSGINAAQNVVNRKLDENLDDETQEKVKRRNEEYRQKTREYLKKKMPQERREQVIFRLKKIILECQQHPDYSQAVQTLLRLAEEYGRHGRNLGKGSADSAKDVRTGLSAAEEDLRTLIERFANGTSTEDLWQSISQIYRDADRDQELRDWFKRVDTYIRRCLLEQGYILADQSTEDWNRLYDQGRYLLRDKYRGHTDRVVDEVKFITDQFDQDPQNKAFGQAVQKLFNDLGTDDNGKPAFKPHLIKDVTDVILPAIFENVAYVPIPRIEYTDPNFDAVIENLVLESDNFMPNVLEVASDNYFRWGRKKIANKRKNSVDIKVTGVQMDLRDVSYHIKRKTGFPSLTDTGVMDLLLPGDGFSFRLKVATPDKKDAQHVFKVEKVDVDVKGLKFKIKKSQHKLLFALFKPIALKAIRPALQKAIEKAIKDQCDKADEFLFQVKQEADRALEEAKRDPENVPNLYNRYYQAAQKRFLQGKEKAKAVTQDKKVNMAVTKQDSIFPDIHLPGGISSKATEYKELAAKGDRWESPVFSIGSAKRSTDIPPVPRIERKAHAVSGGRANGNIDGSANFRGLSAGEGTSGHQLGGQSLTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C352</accession>
    <name>A0A2T4C352_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1334854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C352"/>
    <dbReference type="STRING" id="983965.A0A2T4C352"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="46"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="424" mass="46936" checksum="FBCC510B3D21CDE2" modified="2018-07-18" version="1">MIPNIKISAGDLEPIPMDRDSMDKAAAQTVQVFFLLGAALISIGGRLYVRCRQLGVKKLGLDDGLAVAGMILLVPNVMLAYLMSTQTRWIGNSSVTNGQAGAQLSAVEYYLRESGYKLYLYSWLFHSAALWTFKAAFLAIILRRTAALGRRQAHRYLGFSFLAGTWIATMMALVQHCRPLWKVSPDSGQHCQPATSSVLVWVSLGFDIITNLYLAFAAMSVAAREDKPKKDKLQWFAALLCGLFATGMAIARAVILSSGHNLQAEQNAEFWAIRQLFVFAAAVGFTDFSYHDYSHSMVVGDADVKSSLYPSYFSARQPSLTDSEATILATPKPAELHEKSADLLVKEVLVEGRRNSGIERKVEVSVFQESFIVAPEEPCDICGNYTKSWANDEDANKPEQRSTYFGGNVHFHVPNYGIIYKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C393</accession>
    <name>A0A2T4C393_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1401492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C393"/>
    <dbReference type="STRING" id="983965.A0A2T4C393"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="28376" checksum="3B5AD0D099AFE5BD" modified="2018-07-18" version="1">MLEARLEQASILKKVVDAIKDLVQDCNFDCNDSGIALQAMDNSHVALVSMMLKAEGFSPYRCDRNIALGVNLTSLTKVLRAAQGDDILTIKAEDAPDVMNLLFESSGEDRISEYDLKLMDIDQEHLGIPETEYAATITMPSNEFRRICTDLAAMSESVGIEASKDGVKFSCNGDIGNGSVTLRSHTSIDKPENNVDIELTEPVSLTFSLKYLVNFCKAAALSNQVKICLSSEVPLLVEYNLSGSSYLRFYLAPKIGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3B6</accession>
    <name>A0A2T4C3B6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1402534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3B6"/>
    <dbReference type="STRING" id="983965.A0A2T4C3B6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="336" mass="36628" checksum="AE0AC6A1194D7321" modified="2018-07-18" version="1">MSRYAEAHVFPQGPGDARPTALQIVKDEQMTDKLKGKTIVVTGVSSGLGIETVRALATTGASFILTARDVEKAKRGLGEVFEPSRMKLVEMDQTSLDSVRQAAKTILASTDKISVLINNAGIMAIPDRQLTKDGHELHFGVNHLSHFLLFQLLKPALFAGSTPEFASRVINVSSASHRLAGLQDSDNYSFQRGNYDKWVAYAQSKTANIYMANEIERRYGSRGLHALSLHPGGINTGLMRHVPEEEAKAMIAQIGPEILLSMKSPEQGAATQVWAAIGREWEGKGGKYLSDVAEAKPGPDDGDMAAPTTVSHTYNEKEEARLWRDSLKLVGLEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C586</accession>
    <name>A0A2T4C586_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1332207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C586"/>
    <dbReference type="STRING" id="983965.A0A2T4C586"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="10">
        <location>
            <begin position="331"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="848" mass="95921" checksum="0F6688147EF82298" modified="2018-07-18" version="1">MASHVTYDGVPGSGGTIFKGIKFWVSVSVPQRASIIEKIESNGGVVVPRERDADMLIADHAKKNAPPESYSWKFITESVSAGIIQVEDKYLIDSPPNEPRSILAGPRAKKTRTPFTTHDDALIAKYVLEEGINTAGNVMYMNLAEKYPHHPWQSWRARAVKFVSCLSDEETIRLARLADVAPNSASTTAKHITRHQREERGQAPRTNATSSTGSEPSRDRTEPSPRVTRVSTSESARRSEAASPIHSNRRGHTKAAVHETSGEGTSQHQDSIDSDEPAAPEEQEVVEDERGGEHEAHEHGQEEAGAELEGQQEEEDDAQDDVSVDGGPSSFSERDQFFSDLRDYCEASGKRLHTRCVIEDHEVDLFDLYQAVSAQSVPPDEVDWKQVAEDVGLGRSQRKEVTAGLLQSSYNRYLSDFAEAMMSFEDNEEDPDEVMAEEDGTVFPDEETAPNLTTPRPSQHHRVLSSTLSGPGESRPRKRSPDKRPTTPERLPKRRRTVHTEIPMTPEDKLRTTQRPSAPSSAPGNLHRILDEEEVETGEPSQVTPQQQPSLEETFDMTPSQQLRSETELVLNPEPAETPTLYFSPMARSSGRRNDGRLETIHEEAPSTYTPTRSRPKKRALPPSFEQAQPPQSREQPRERQQHEELERRQQQQQQQRQQEDRQQAESRRRDEQQAHEQDRAQAPQRQRDSGQQQRPQQSRQTTADTSDPDEDNVEEKKQQYRNCRKDYLIQGYKEHEIVEAMRRTTMTPGEAMDIVIKSIRDGRGVPDDCEGIWTDRDDSQLKYVVRVSGLGGMPGGDGAEERRRKEKAQKMLDRLLYKHGEARVKLRKKFLRELALAQREMERGMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5I2</accession>
    <name>A0A2T4C5I2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1401174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5I2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5I2"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="519"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="627" mass="66889" checksum="12B00C9E533C4592" modified="2018-07-18" version="1">MGAAAAAAAVGRVPVDEGFLHHQKWQPKVLSATDGLSIRTGPTEPALFTGTIPDHFASVVSLHGDRPAVIARAPTPAARESSLTYHGLDLVSNRLASSLASLGVRKGDRVAVSLGNGAEFAALTYALFKLGAVLVPLNPSFNAHQVQAALSHLGAELLIIGAVTDLAYRPGKGRSNRSLLETVVGDLHRSAIQSEAVPTLRRVVVLDNRANHPGVDFPLEDLAALSPYNDLLQGSDRAVVPDAPLDPSDTINIQFTSGTTSMPKAAQLSHTAILNNGAFIADRMGLAPSDRVVVPPPLFHCFGSVLGYMATATTGAAILFPSPAFDPVATIRMAAEHEATGLYGVSTMLVSVFEALDAGGLPVPQHLRKGIVAGSSVPEALMRTIFARLGLQDLVICYGMTETAPVSCMTRPSDPFVQRTASVGTPMPHTTVKIVDPCDPERIVPIGERGELAASGYLVMKGYYGDPERTAQVRRREADGRTWLYSGDEAEMDADGFVRITGRIKDLIIRGGENIHPLEVENCLFQMPGVQEVSVAGVPDERLGEAVAAFIIPRAGWTTSDAAESEGDEAARRLTKEGVRNWVRTKLSSHLVPKYVFWVNDYPKTASGKIQKFKLQEMAKKQLAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5P3</accession>
    <name>A0A2T4C5P3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5P3"/>
    <dbReference type="OrthoDB" id="5130140at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="306" mass="34211" checksum="AFA4770C5B3E2DD8" modified="2018-07-18" version="1">MSHRPDHLTGPVTEGIGLRFLNEAWNDSISNGHLLAIRWNQVLDEARSPELGLFKITYPRDGDVVYELVSNLTDGMDYANATCLWTPNHLNDELYTLWLSSSRDARSSWTTSPPWRLKEHVKKQSHRSPRRWAAPVVIPILVILTVYTLGLTLCVVYRRRRNARRERESSEGENTERESAESPCLLEDADRHPSVDTAATLAADDEEDSKKPQIWLLTQSASGSLLLASPPRGKDSDSDATLVSPTSLSSEPLLMSPISLAEQSPTSIRSERAFIALSDPRDHRAVVASRLGRSLRIIVPSDDVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C640</accession>
    <name>A0A2T4C640_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1240544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C640"/>
    <dbReference type="STRING" id="983965.A0A2T4C640"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="267" mass="29412" checksum="04BEE4D777C1AF68" modified="2018-07-18" version="1">MTAEAISGSGSRPASGSPKPLRLLILEADTPQPDTEAKYGGYRGVFTALLTAAAEAMDPPRPLPEVATVTAHNIVEDMQSYPPLDEVDAILITGSRHTAYEDDPWILKLVEYTRQAIDSGRIRVVGVCFGHQIVGRAMGARLGRSDKGWEVAVTEVNLTDKGKDIFKLDKMRIHQMHRDVVLEYPKDSIPLGGNDICPVQAMYSPGRYITVQGHPEFTEEIVSEILTNRHKAGIFADDMYNEAMKRAPNEHDGVAIAKAFLDFMRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6H1</accession>
    <name>A0A2T4C6H1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1332474</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6H1"/>
    <dbReference type="SMR" id="A0A2T4C6H1"/>
    <dbReference type="STRING" id="983965.A0A2T4C6H1"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015486375" description="Glucanase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="478"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="443"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB77122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="514" mass="54208" checksum="9A7C3DB5E25443C9" modified="2018-07-18" version="1">MYQKLAVISAFLATARAQSACTLQTETHPSLTWQKCSSGGTCTQQTGSVVIDANWRWTHATNSSTNCYDGNTWSSTLCPDNETCAKNCCLDGAAYASTYGVTTSADSLSIGFVTQSAQKNVGARLYLMASDTTYQEFTLLGNEFSFDVDVSQLPCGLNGALYFVSMDADGGVSKYPTNTAGAKYGTGYCDSQCPRDLKFINGQANVEGWEPSSNNANTGIGGHGSCCSEMDIWEANSISEALTPHPCTTVGQEICEGDGCGGTYSNDRYGGTCDPDGCDWNPYRLGNTSFYGPGSSFTLDTTKKLTVVTQFETSGAINRYYVQNGVTYKQPNAELGSYSGNELNDDYCTAEESEFGGSSFSDKGGLTQFKKATSGGMVLVMSLWDDYYANMLWLDSTYPTNETSSTPGAVRGSCSTSSGVPAQLESQSPNAKVVYSNIKFGPIGSTGNPSGGNPPGGNPPGTTTTRRPATTTGSSPGPTQTHYGQCGGIGYSGPTVCASGTTCQVLNEYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6I4</accession>
    <name>A0A2T4C6I4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1400092</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 12"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6I4"/>
    <dbReference type="SMR" id="A0A2T4C6I4"/>
    <dbReference type="STRING" id="983965.A0A2T4C6I4"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB77181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="356" mass="41269" checksum="3C6FDA8049CF6FAB" modified="2018-07-18" version="1">MSRSNPPNNASASRKISFNVSEQYDIQDVVGEGAYGVVCSAIHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSYESFNEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRTLFPKTSDLALDLLEKLLAFNPVKRITVEDALKHPYLEPYHDPDDEPTAPPIPEEFFDFDKHKDTLSKEQLKQLIYQEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6J3</accession>
    <name>A0A2T4C6J3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1400057</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6J3"/>
    <dbReference type="STRING" id="983965.A0A2T4C6J3"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="74"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="590"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB77142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="787" mass="85846" checksum="ACD786ED94D1DD8A" modified="2018-07-18" version="1">MLASRQVLGSIARSRALGGAASSVRRLATVSDSALDRKVRQNNWEENNFINYKKMSENLSIVRSRLNRPLTFAEKILYSHLDDPHGQEIERGKSYLKLRPDRVACQDATAQMAILQFMSAGMDSVANPTTVHCDHLIEAQVGGAKDLERAIGINKEVYDFLSSACAKYNIGFWRPGSGIIHQIILENYAFPGGLLIGTDSHTPNGGGLGMAAIGVGGADAVDVMANLPWELKAPKVLGVKLTGQMSGWTAPKDVILKVADILTVKGGTGYIVEYHGPGVEGISATGMGTICNMGAEIGATTSLFPFNDRMYDYLAATKRKDIGDFARAYASELREDEGAEYDQLIEINLSELEPHINGPFTPDLATPISKFSQAVKENNWPEELKVGLIGSCTNSSYEDMSRAASIARDALDHGLKSKAVFTVTPGSEQIRATIERDGQLKTFEEFGGIVLANACGPCIGQWDRRDVKKGEANSILSSYNRNFTGRNDGNPATHSFVTSPDLVVALSIAGNLHFNPLKDKLVGKDGKEFMLKPPTGDGLPVRGYDAGQNTYQAPPKERADVQVQVSPTSDRLQILEPFAPWDGKDAKDVPILIKAKGKTTTDHISMAGPWLKYRGHLDNISNNMLIGAINEANNEANKVQNFTTGEWDAVPAVARDYKKKGVKWVVVGDWNYGEGSSREHAALEPRHLGGLAIITRSFARIHETNLKKQGMLPLTFADPADYDKIKPDDRIDLPCTQLAVGEPLIMTVHPKEGKPFDVKLLHTFNEAQIEWFKNGSALNTMAKKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6N2</accession>
    <name>A0A2T4C6N2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1420994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6N2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6N2"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="621" mass="69940" checksum="1F8692D298FE0A0B" modified="2018-07-18" version="1">MVYQGKPSRGCQMCRTRRIKCDETKPTCKQCAKSRRQCPGYRDEFDLVFRNETQATEKRAQRASKKALAQRMSKFAASSTPEPISPNAAHSSGCSRPPFGPSQHMPSMAPSYGRKNQQTPWTGLYSLLQKPQMDLDGQVTCHFLSNYVLIPRSGNGRGFLEYVVPLLRAEEVAPHFKAAFDACAMASYANAQGDQLLVERALRTHSKALGAINVALNNPDTIKQDSTLAAILLLGLFENITTRNLGMLAWGPHIRAAIQLVRKRGRKQLRTKIGVALFIAVRTQMIVHTLSTAKPPLMQVEWWINSDAVRDMYASQCQRLGIRAGEIRAEVNRLMSQLPRNMESVEALRDMIRQAQAVDFECIRWAETLPEEFRYRTILWQDEIPDADYHQLEVFPGRVDAYPDLWVASLWSMMRVSRIILASLVIRCAAWVSSPVDYRMAPEYATARRICVENITDLIASVPYQLGWFSTRKHLFQQASLSGFACGEDDTTKSLSGYFLTWPLACIQGQDYTTDNQRAWVKGRLTYIGRHLSVSYALMLTQLNYRTPSMLIRMDGLMANSPSVNVEKLLSMKVAKPSEVLATGPMAPQLFRQQVFHGQPTVLMPQHAAISTYDDTSPEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6P0</accession>
    <name>A0A2T4C6P0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1420998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6P0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6P0"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="183" mass="20798" checksum="16A9A06D69123CF8" modified="2018-07-18" version="1">MAVSSTKQLPVALQYVQYEHRLESQYLPAIRALISKDLSEPYSIYVYRYFLCQWSHLCFMALDPKDSSLIGVIVCKLEVHSSHSPPTRRGYIAMLAVASHFRGRGVATALVKKAIEAMASRNADEVVLETEETNTPAMKLYEGLGFIRSKKLHRYYLNGNSAYRLILLLKAVDPDHDPNYDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6U4</accession>
    <name>A0A2T4C6U4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1400181</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6U4"/>
    <dbReference type="STRING" id="983965.A0A2T4C6U4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="14 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB77280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="458" mass="51622" checksum="7689E97F4684E9EE" modified="2018-07-18" version="1">MATPIPKPPGVPLLGNIFDVKPGNTWDSLRKLAEKYGEIFQIKVLGQTIVFVASAALAEELCDEKRFRKYVGGPIVEIRAAVHDALFTAYDDEPSWGVAHRIIYPKLSPDAMKGHFGEMRNLATELFNAWRGLGDENTICPLEQLNRLNLESTTYVLFGKRLNTLIGPPHPEIQAMEDSTSEAMKRPTRPGVLNSLLYGRKFRSSIKIMRDYAADLVKYRQENPTERQDVLAAMMNTPDPETGKKLTDSQVIDEIVSMPIGSSTAPCLLAWTIYFLLKNPEVILKAREELDRVIGTGEFELEHLEQLEYVQGIVRESLRLSSAAPGFNVEPRPKEGDKSPVLLGGGKYQVAHNQAMIIVLHGVNRDPAVFDDPLAFRPERMVGEAFVNLPAAAKKWFGNGKRVCIGRYYALQWSLVVLAKMIREFDFEMADPEYKPELDGWFNIRPIDFYVKVKPRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C742</accession>
    <name>A0A2T4C742_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1390709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C742"/>
    <dbReference type="STRING" id="983965.A0A2T4C742"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015760087" description="WSC domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB77380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="297" mass="31010" checksum="418783A654EF2AF1" modified="2018-07-18" version="1">MKSSTLLSGALVAAAQVYTALGATAVRAHEMSHVIRANIQLPSQPPVPNAYRSQGCWSSKGNMTHATAVKSTTVSSGSCNDYCKSKDMPVSGLQGDECFCGLVYPPQGDQVEDSKCSFPCPAYPKEACGQIGQPGYFSVFNTGVNINPDYYEPPKSTTSSPSSTSTSSDAEKSSAAAGASGIASASAEPTADGDSKKKTNVAGIAAGTVVGVVVLGGLLGAAFFTLRRRRNAEIEEEHRRNAAVNAFINGSKPPSTSGSISMTDSRLDPIMAHRRLSDGSIADNEDYSRRILRVTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8I3</accession>
    <name>A0A2T4C8I3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1400795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8I3"/>
    <dbReference type="STRING" id="983965.A0A2T4C8I3"/>
    <dbReference type="OrthoDB" id="5425917at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14297" checksum="CE3667A718309FCD" modified="2018-07-18" version="1">MSGRASSGDSPPSEEKGSNNNMDKSLRDAAVVPQSDGEGFVNSYEQEDFWTRNGLNAKSFQKKHYGHGLVELDRAMKTRHLQMIAIGGSIGAGFFVGSGGALAKGVSWPISGLKRRRKKKKKNKGREGDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8R5</accession>
    <name>A0A2T4C8R5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1391119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8R5"/>
    <dbReference type="STRING" id="983965.A0A2T4C8R5"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="446" mass="48722" checksum="5B0AF08EC7242613" modified="2018-07-18" version="1">MAIINQVFEAAHVVARAATVTASATITTSPQTAIPSNTNNSNNNNKGSGSSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNARNRARMTNEDGEPITLENMPRPHRRRREKKLMTMDEVNDKFPMMKYKTWVSQRAREGLPTAGGVGTPSRPNSIHHAEGAIPDVAAKERASAEVKPVQEDASTATKTEEDKEIAVKADDDKKDATTVAETPEDGPVNPIHNLKRTTTEEEEDEEDEEEDDEQINAALPPELLNTSGDTCAICIDTLEDDDDVRGLTCGHTFHAVCVDPWLTSRRACCPLCKADYYVPKPRPNPEGDAAAAGNNANLDPRQNSRMNLPVGFPRTWFRSSGNRNDNSRHSDNSRPPTSLLRLPGRRRAQTAAVNAATEAQQNPSATNASEPAQPSAPATMLSSVRHALRFGRTVEPPPRMNATETVTPSQLESGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8V3</accession>
    <name>A0A2T4C8V3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1329529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8V3"/>
    <dbReference type="STRING" id="983965.A0A2T4C8V3"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="249" mass="27656" checksum="E729B0145933BD55" modified="2018-07-18" version="1">MPTFHVEIRRPGYHHRPPLEASSIHQLTPKANKGANRQTPSSEHSRYVQMLLQQDDIPLLHNVLASVFVWLLLAGFLVFPGTFTSLQASVDKQGDNDNDHTFSKEAAKLIVKSIKNIPLLVIAIVMCGISAIGMLVLTVLHAKNYVWIVNKLFLPGMTNSLAGLVSTLIGVYSQQHGTWSITARTTAITEGASLAVCGGLFLFCRMLLLRKVKETHEEHYKGWPGHRYSKQLFPDSPSSTWKKTSDVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9A0</accession>
    <name>A0A2T4C9A0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1461384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9A0"/>
    <dbReference type="STRING" id="983965.A0A2T4C9A0"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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    </dbReference>
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        <property type="term" value="P:steroid biosynthetic process"/>
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        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
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    </dbReference>
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        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
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        <property type="entry name" value="3Beta_HSD"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="255" mass="28245" checksum="A206DD913CFB438A" modified="2018-07-18" version="1">MASEKRGDLGSVLVIGGNGFLGHHIVNQALSSWTCSAVASVDLRCTRNINAGASYHECDITDAARLTQLLQPELERLTLAGFLRAYDNNKSHIQLGDNTNIFDFTYVGNVAHAHLLAARLLLATAASPMIPLSHERVDGEIFFVTNDSPVYFWDFARAVWRAAGNDKGTDGVWEISRGMSLVLGSASEAFFGLIGKPPTFTRLRAMVSTMTRYYNISKAKRVLRYEPLWTLQEGIDRGVGWFMEEKKKEAAKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9F9</accession>
    <name>A0A2T4C9F9_TRILO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">M440DRAFT_256006</name>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="159" mass="17969" checksum="7E7980C9BE78BDA9" modified="2018-07-18" version="1">MSRDTISGGRVTSPRRPNLLLLPLSSITFSLPLARRPRARVSRLYDGSSHRLCTVRFISLYSAFYRHIPNLTIAKSCSLSCSHIIVSPLCFFSFWTTTLYQNIRAAQGRIIVIHCFNGVLSLCQKKKKENHGSFAFFSLIVTKNLLYEQCGRRVGDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9I8</accession>
    <name>A0A2T4C9I8_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M440DRAFT_1399364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9I8"/>
    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="54" mass="5864" checksum="B5AFBF90474B9F57" modified="2018-07-18" version="1">MAHGRCRAVIATQVSSLIACKTRAQQASPPSTYPRAHRTEPRLNPGVLTKTNGY</sequence>
</entry>
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    <accession>A0A2T4C9P2</accession>
    <name>A0A2T4C9P2_TRILO</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1468763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PTB78280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C9P2"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="234"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="649"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="821" mass="92670" checksum="8BF5A46E804547FC" modified="2018-07-18" version="1">MVNGVSGVCQTTRSSPLPEFPVTLTDPQHFESSDVAPVKGQIDPGFTYITYALLDEQNLELEITCSLETGNVSKARSARPLSTPCRLNIVLYGDISLLEQVGSFFEEHDLYLQDPLCCSRNVLYRNPHKVCDASGHGIWTSDLGREHAKSAIIETTQPRPELIDILNSQEDLVTAQQPGSIRSTMKSHQLQALTFMLQREQGWAWDGSRPDLWEFCPESTGSYYLNRVSGAAQVEEPPQFYGGIIADSMGLGKTLSMISLIASDLLLNIQDPSSITGANAEESSGRTLIVVPPPLLDAWEEQLKQHVFPNSIAWRRHHGKFRIAHKSDLEECLVILTTYQTISSEWTDNSDTKHSLLFQIRWRRIILDEAHLIRNSGTRMSRAICSLSSVSRWAVTGTPIQNRLGDLTALLRFLQIYPYSDEHIFNADMSSLWKVGRIDEAVKRLKRLAGCILLRRPTTIIQLPSRHDFQRFVDLAPAERELYQDFRMRTKSHMEQALSADGTFTKAYSYANMLQRIEAMRMICNLGVHYRVRYDLQAYNEQTSQSWAESAQNMFNIRRGISSIRCRLCLCVADSTEIAVDETAPPSMFSQCLEFVCSTCIPIRSVHQVLRSCSHENLCPTAPVSTEIFDTDDASWLSMAQLGAGLPTKISMLIQDLQSQPHNLTSILNSVVFSSWRTTLEIIELGLKQTGIPCLRFDGKVAQKDRHAVVERFRKDPTIRVLLLTISCGAVGLTLTEASRAYLMEPHWNPTLEDQALARIHRIGQTKEVTTIRFIVKDSFEERVVELQQSKTDLAEVIHRQNESSQSAEARRPLEWLKALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9S1</accession>
    <name>A0A2T4C9S1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1189803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9S1"/>
    <dbReference type="STRING" id="983965.A0A2T4C9S1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="577"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="761" mass="84835" checksum="33161A09112B6B2B" modified="2018-07-18" version="1">MSRLPRDARLYASDSRIPPEPYNLYAFYSASDGPWIPNAAIPPAATLNQSSRPPAFSSGARGFQGYRSVGLPSECGTGPEDSGYGGTRSTYSLVESAASIAENDRCTETGYLETQTAEQLIGDLNISSAIPIYQQPMPYSQSPPVEYRCDQCDAVLKTRSELKHNKPYKCNYEGCPKAVHGFSTPNDLSRHKRTVHREYNENVPVYICRHDPCTRKKEKPWPRADNFRSHLSRSHGIHLKADHDLRQYRHQLGVARPQGPRHHGDQIPNVDPGRRTTQLQDPPLVHARPDEAAVRSEATEAPELRGVGSSVADVDPGPRPAQLQDSPDLRGQQSPAPPSDPVHGELPRQNSSPCPPSGVKPDLAQQSDTLEDMGLSSFPASEHLASTQIVETASMDDAPLGNPETTSPGEEARPEAFDRGEVILSGDEEEPHSHQGSSPPSTRSLEPKPGAPQICSFEAQQTTAGSDDAPGSPCDALADTVTFNSRNPSELFTFLKHLPMDMALKNGTSDVLLFLKKFPKYLLEEALSHDDHEGTANNLASDEGASQKATVACPDCGKVFVRQCELRKHMKRHKKPYGCTYKTCNKHFGSKNDWKRHESSQHFQLESWNCNMPGCDKVLPHRELFRSHLLNHHKLTDGQEVENKLESCRLGRHCDPRFWCGFCDRFVEVTGEVVNSWTKRCDHIDNHLFGKDGMEKRTMSEWHYLEDKLAEEEREGVALERPSETSEKRKATDDLALRSSKRRLYRWKCLPGKPLPTPTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9T4</accession>
    <name>A0A2T4C9T4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1399489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9T4"/>
    <dbReference type="STRING" id="983965.A0A2T4C9T4"/>
    <dbReference type="OrthoDB" id="5355161at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="421" mass="47273" checksum="36CF739E3C3AFD52" modified="2018-07-18" version="1">MTDSAPPKRLACIACTRAKRKCSKQTPSCRRCADKRLVCRYPAPRVAPPYDLVFSQDGAVSVVPVPGASDRNPLPTPPSQRGEQQQQQQDEQPQSQTELSRSAHESQTAADSLRNPWFLSPSSWDIDHKHGPVPSQIYFSDEALTWFIDQLHVWLRQWTAEGHCPFIHRQLWKIHLPDHIQDAFASLAAYHSKTPATERTVLRIIETRVNNLVDTQNASGVGDFGVIMLDPACHLARTQALLIYKIIRLFDGDIRARAQAEKNIDTLALWARQLWQSAGLALSSSSHKEPVDRASSGPVDTQLRTDGTLTSTWQAWIFSESIRRTYMAATLTEAVYLTLKQGWAPCPGGIIFSGGTGLWDATSPVAWMKHYQENAVNGIRCIEGEQLFSSARASDVDEFCRATMIVSYGLERFERWRNENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA68</accession>
    <name>A0A2T4CA68_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1468849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA68"/>
    <dbReference type="STRING" id="983965.A0A2T4CA68"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="118"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="396" mass="45238" checksum="387B943EC6CB7396" modified="2018-07-18" version="1">MYSAEPARSDSSIEPPTGADSSSSSSDSDASDADEPIAPVAVAPPPKAVSAGKIISNLNKVDLDARRKDAEAAEARRIAAEKAERLAAEQGFVTEEEESEEEESEEESGSEESEEESEEEEEAPRRLMMRPKFIPKAQRTATSKDPEADAEAARQAEEEARKRAADELVEEQIKRDLAARAAGKKHWDDEDDSGSDVDTTDGLDPEAEEAAWRVRELKRLRRARQAIEERERELAEVERRRNLTEEERAAEDEAFLARQREEKEGKGKMAYMQKYYHRGAFFQEETAAAGLLQRDIMGSRIQDDVRNREALPEYLQRRDMTKLGKKGATKYKDMRTEDTGRWGAFDGDRRRGERRFDGGEDDRFRPDDDWNRRKRSTSRERDRYDGDKRRKIDGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA79</accession>
    <name>A0A2T4CA79_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_360508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA79"/>
    <dbReference type="STRING" id="983965.A0A2T4CA79"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="17852" checksum="2CC373D80CF3860D" modified="2018-07-18" version="1">MSIPSPLGGGSAQLPQMGNQDPNVRAIQGAMESCYGKSIMSGVMGFGMGGLFGLFMASMSYDTPFGSPLQGANGQPAITSLPLRQQLKIGFKDMGTRSWSMAKNFGKVGALFSGIECGIEGLRAKNDLVNGVAAGCLTGGILAKNAGPQAVAGGCVAFAAFSAAIDAYMRQPSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAE1</accession>
    <name>A0A2T4CAE1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1329030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAE1"/>
    <dbReference type="STRING" id="983965.A0A2T4CAE1"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="573" mass="62034" checksum="FD62ECA636CD92F1" modified="2018-07-18" version="1">MRRTSVSLPTKHAAHDPHEKTDRYLPSHRRKGPLASMKDTMLSQAQKSRWLKTGALVLILMCLFYWLSPTGVEVYNKSPLGEASDIKSPDNVPATNAPPANHGAAAAGNGAPNSGQAPADSSYGTDKCSKSYSKDKPIVQYVLMIDAGSTGSRIHVYKFNNCGPIPELEKEEFKMTEKSVGGLSAFKNDPVAAAKSLDPLMAVAMEHVPDALKKCSPVAVKATAGLRLIGKELADAILAEVRRHLEQDYPFPVVSAEQNGVAIMDGSDEGVYAWITTNYLLGKIGGPDKSETAAVFDLGGGSTQIVFEPTFKDAADGGMPEKLAPGDHKYELDFGGHKFDLYQHSHLGYGLMSARKALHSALIDDLAKAKGDDQTWMNAPIVHPCIAPGTTKQIDVEVNGGEARSFNFTGPSQPSPAQCRNLAEKILKKDAECALAPCSFNGVHQPALAKTFAKEDVYIFSYFYDRTKPLGMPDSFTLREMHDLTQKVCAGKEAWDVFSSVPGALEELEDRPEHCLDLNFMVALLHTGYEMPIDREVKVAKKIKGNELGWCLGASLPLLAPGSGWSCKIKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBE6</accession>
    <name>A0A2T4CBE6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1373866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBE6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBE6"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF10">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="192"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="66570" checksum="66EFDE8974FEDD54" modified="2018-07-18" version="1">MVTAWQPPLNYRTRPVAVLGAGVLGRRIACVWASTGYTVKIRDPSKQQREDGIAYVEENVASYAQKTGKTPGKVMAFEDMEDAVADAWMVVEAVPEKLELKIDVFAELDALAPADCILATNSSSYKSSDLISKISPARKAQVLNTHYFRPPECMLIEVMTCGYTAEGVIPFVVERLREAGLMPYVARKESTGLIINRLWAAIKRETLTILAEGVSVPEEIDALWKEMFAKSRLLPCLTMDLVGLDTVAFIEEHYIAELGLSPEKTVDFLKKNYLDHGKLGAKCAKGGLYPPSATKTTASNGVLSETKLIVLDVGQSAAEPTPTSGQVLQFGLDGKPPKVLVDNLYLPDGVGVDHPSGRMFWTNMGYPGKPNGSVCSAELDGTDVRTIIAPGTINTPKQLAVESLSKKIYFCDREGLSVFRCNYDGSSLERLIHNGRSEGDADMRDATNWCVGIAVSPKLGKFYWTQKGPSKGSRGRVFCANIVLPAGQSAHSRDDVVCLAEGLPEPVDLEVNEEANTLYWTDRGEIPFGNSLNRLQLDEAGLAAKTASSGGHEVLSRHFKEGIGLKLDVKNRRLYVTDLGGRIYQCDLDGKNKTIVYSDDYRAFTGIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBI9</accession>
    <name>A0A2T4CBI9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBI9"/>
    <dbReference type="OrthoDB" id="9981319at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="17066" checksum="6F32C84C43F6A3A7" modified="2018-07-18" version="1">MPLYDIEYVTPLTLEQQEQPAIAFTDEHSQRFNTPRFFINVRYTDVSNQVVFRGGPGSNRTKEVYLDHCKQIVTHWERIIGCEDEEGLRTVWVMGALTTALEAGIGRPKTGEENQWIGDNMQNIQALAAAGDEDFVELLHELEEKKQGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBT6</accession>
    <name>A0A2T4CBT6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1419417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBT6"/>
    <dbReference type="SMR" id="A0A2T4CBT6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBT6"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015499820" evidence="8">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="95"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="407" mass="42632" checksum="E51788DA4B0DFFAB" modified="2018-07-18" version="1">MQTFGAFLVSFLAASGLAAALPTEGQKTASVEVQYNKNYVAHGPTALFKAKKKYGAPISDNLRSIVAAKQAKQALAKRQTGSAPNHPSDSADSEYITSVSIGTPAQVLPLDFDTGSSDLWVFSSETPKSSATGHAIYSPSKSSTSKKVSGASWSISYGDGSSSSGDVYTDKVTIGGFSVNTQGVESATRVSSEFVQDTVISGLVGLAFDSGNQVRPHPQKTWFSNAASSLAEPLFTADLRHGQNGSYNFGYIDTSVAKGPVAYTPVDNSQGFWEFTATGYAVGSGKLNRNSIDGIADTGTTLLLLDDDVVNAYYANVRSAEYDNQQEGVVFDCDEDLPSFSFGVGGSTITIPGNLLNLTPLEEGSSTCFGGLQSSSGIGINIFGDVALKAALVVFDLGNERLGWAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC73</accession>
    <name>A0A2T4CC73_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_229992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC73"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16470" checksum="5B9AEF06FB1D7EC6" modified="2018-07-18" version="1">MASLSGMATSLVLHCGEFLSLSLGYSNRSNATLRTCIHCLGIPWRRILSSALSLRSMINSALRRRWEGRCSLFDSTLTRQIPLPSFEGEVRLTDGKLKLGTSLSLGTLTSWDIRERQHGSYGPSPTHGSCSVSAKGLTVHPSFRQRFCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC88</accession>
    <name>A0A2T4CC88_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_231276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC88"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="81" mass="9185" checksum="F3ED3335B4D71C34" modified="2018-07-18" version="1">MQGFRVASPVPRGDTCQGMLVLVIQACRHRKFYAVSFCASKHAIPWRRSILDRNEQHGIRILCGIRGKVGITWLKKPSHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCQ8</accession>
    <name>A0A2T4CCQ8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1468221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCQ8"/>
    <dbReference type="STRING" id="983965.A0A2T4CCQ8"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="146" mass="16511" checksum="3C099F191448DAB5" modified="2018-07-18" version="1">MVVYSFYIFDRHTECVYAKSWLPPQIPGTPAPVLSTGSDDAKLIFGTVFSLRNMVRKLGGDDDAFISYRTGQYKLHFYETPANLRFVMITDTGSASMRNVLHQIYINLWVEYVVKNPLAPVEHKGGAGVNNELFELGLDQFIRGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD04</accession>
    <name>A0A2T4CD04_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_237995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD04"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="17921" checksum="C25E95E0B18431E3" modified="2018-07-18" version="1">MRWGICTGKRPVCPGIPPDGQVAAWGPRLRIQGRPSAPCPRTPSRNLRLPLQTPTPPVRTTGLVCLTRMPGGICQSRHPTQLSLNGPCIASQLEAGRHRSDFIWYRLIFLRRKTEMKRGRRRQKKKKRWRQLGIWPTYYEPALRAIPVLPSSHLTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDD0</accession>
    <name>A0A2T4CDD0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_240870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDD0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="85" mass="9706" checksum="D176AE0B123A433D" modified="2018-07-18" version="1">MMPCEMQARRVFFLLGGLNLRHGNVFDCCTSCRESEVDSYAAQVDFRIWASCLHFDGDKGSFFQSIPRVQRLVDLQTMFAAFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDE5</accession>
    <name>A0A2T4CDE5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1326481</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CDE5"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="14"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="940"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2483"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="940"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2568" mass="277803" checksum="714ED99E9B0D3AEA" modified="2018-07-18" version="1">MGSLGPDCQSRYASEPIAIIGMSSKFAGGATNTDKLWQMLAEGRSGWTEFPASRFRSEGVYHPNNERLNTTHVKGAHFLQEDVGLFDAAFFSYSSETASSLDPQYRLQLESAYEALENAGIPLTQIAGSNTSVFTGVFVHDYRDALLRDADNLPRLMATGTGVPMMSNRISHFFDLRGASMTIETACSSGMVATHQGIQSLRTGEADMSIVGGANLTLNPDMFKALGSAGFLSADGKSYAFDSRASGYGRGEGVATIVMKRLSDALAAGDPIRAVIRSSLLNQDGKTETITTPSLEAQIDLIRQCYARAGLDPRDTQYFEAHGTGTQAGDTVEARAIATVFSSNQDPLLIGSIKTNIGHTEAASGLASIIKTTLALEKGVIPASINFEKPNPKLSLEDWHLKLVRQLQEWPAARTRRASINNFGYGGANAHIVLEDGASWAPSLVEDTYHKESNKTDSKVLVLSGKDEQACRTLVSNLADYLQRVASTEDEPARLLDSLAFTLGQRRTRFSWVAAHPVPVTEGIEAVANTLLSPKFKPYRSSRRPRIGMVFTGQGAQWWAMGRELRDAYPVYKASLDEADAYIRQFGADWSLVDELSRDAASSRINESGLSTPICVAVQISLVRLLESWGVVPAAVTSHSSGEIAAAYTVGALSYKDAMAYAYHRAVLAADTSLRGPVKGGMVAIGLGREETEAYLRRLTGSGKAMVACVNSPSSTTVSGDFSAVKELEELANADGVFARLLKVETAWHSHHMTAIANVYVEALDNIKRKNSRNGSLIAYSSPVTGGRVTKIEEVARPEHWVKSLVQPVQFVDAFTDMVLGDLGNSTSNIDVVVEVGPHTALGGPIQQILGLPAFKGLQIPYFGCLVRKTDAKDTMQALAANLLQQGYPLDMDAVNFPHGRGPRVKVLTGLPSYPWNHQVRHWVEPRFNKALRERSVPPHHLLGSLVEGTNLESPTWRHTLRISESPWTRDHAIQSNVVYPAAGYICLAIEATKQLHTLNHTKTEAKEVWGYRLRDVDFLQALMIPDTSDGIEIQTSLRPVSDKDVALQGWKHFEVWSVTSDNRWTQHAKGLISLEYEASAKVSGPEAGDFSIRGYKRQIPPAELFANLKALGIGHGPVFQNMRHIVQSGSERRSVVLTAVPDTSVPNDLPREHVLHPVTLDSFITSPYSAVPGAASRETAAKVPRSVKSFWVSSNISHAPEHVFKAHSHIIRDDKHGMEADVIVANDGHDDNAVLLEMKGFSYQSLGRSVSLQHAEPWESQLCSSIHWHPDISVKLPATISSVEQELSYRVNSAEDAGTEISSLCAYFMQKALASLSDSDFSPKVSHYSKYYAWMKSAVQQAAFAKIDENDIDQIARERADGEMIRLLGSQLVPILRGELTPAEVMEQDKNLLSRFYNETPRAKRTSSQLSGLLRHLVHKNPRARILEIGASTGGVTGSALAALGTAASGGPHVSLYHYTDISDRAFYSAREDFADWADILAFDVLDIEHDPANQGFTVGSYDVVIASHAVSSTTTTIAGVLGNIKSLMKLGGALLFTEDVNPSIDVQFVQGLFPAWWFGESLPEEGIESSPLLSVPLWDRSLRQAGFTGIDYELHDSDDVDAFVSATILSTLPPHPAGQSGIDAGKVVIATSEKAGNPPSEWLKALQNSIASSGTEVEGTEGKVLPSVHSIESTTSTAALYSDKICIFVGEINEPLLYNLDAASLEGIKAMSTGCKGLLWVTRGGAVDCERPEVSLATGFVRTLRNEYVGRKFITLDLSPKGSLWQESGHEAIAQVLQNAFGQPLSEHSSAPDKGPVELEYALRDGVILIPRVYHDVAKDDALTPKVLESEEDTQGITTVESFYQQNRPLCFQPELLVFGDDLSTSAYKDTLPPRLVEIMPRAYGAGMHPAEKAIIGQECSGIITRVGSEASKHGYSVGDRIICLLQQSSFSSRAIVDWTSVVHMPTRLSFQEAASLPTAFLVAYLALVETARLKNTQTVLIHNGAGSIGQAAIMVAKHIGATVFTTVASPKQRDLLATEHGIPSHHIFDSANASFGTAVTAATNGRGVDVVLNSLTGPLLQTSFNLVAPLGHFIEVGKQDSLANSNLEMLPFTRGVSFSAIDVSSLLQHRANEMHRWLEEVVRLFELEALAPVSPIMEHNIGEIAQVFRLLHTEDDTGKRVLSVAHDEMVSVLPRTRAAARLSPDASYLIVGGNGGLGQAVAHWMVSRGAKNLVLLSRSAGQSPKMAVLAEELREAGCHRVLPVSCDVAREDDLARAMDTCAQEGLPPIRGVVHAAFVLHDSFVENMTLEDYKYTIQSKVSGAWNLHNQFNLPGDLDFFVLFSSINGILGYASQAAYSAAGAYEDALAHWRVKNQGLPAVSIDLSLVDGVGYVAEASAAEAMRKSLIKAGRRVINEEQVLASLELAIVSPYDPQFILGGINSGPGPHWDVDGDLGRDMRLLALKYRQSAAADGQDGDDNKAGSGGDSLSVKIASASSRDEAILVVGSAVAAMLADMFLVSVEEVDLNDSPSQQGIDSLVAVEVRNMLFSQAGAELSIFNIMQSPSLAQLVADVVDRSTFAKFAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDJ0</accession>
    <name>A0A2T4CDJ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1173832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDJ0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="14266" checksum="C136B3926999A2D9" modified="2018-07-18" version="1">MHLRLTSSHTLSSPILLKSPAVCLLSEYVNRVGSTCSCLPTRDRNRASQSPSYVEFRRSPRSITRSTTPKNHDTLQLSSTTYMYLTSPNSPNLHPHGHDQTNTNRHHPPSHYYTRIFPPPPSMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDU5</accession>
    <name>A0A2T4CDU5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">STAG-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1326275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDU5"/>
    <dbReference type="STRING" id="983965.A0A2T4CDU5"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="343"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="975"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1177" mass="130992" checksum="16CA6F5CA284DACF" modified="2018-07-18" version="1">MDASATASPEPEARRRSGRVVKAPTKYAPEPTAPAAKRKRNDDEVEDDADEGAANGDGASDEDMSDVPSDADSDQDHPSPKPRKAAQTSRAKKPSTKKPKINGARPAMAGTVARIPSRPKKTVRIDAGEKGTGLFADIFASGDSAQFVAKQWLEKYKESDAAALGDLVNCILRCAGCDLEVTVDDIRDPENIPNRLVDLQSVYQEQQIVDYPLIARAKSTRSFRDLLINFFQALITLLHETDVMYKDVDLVDNLHAWLASMSSSPLRPFRHTATTISLAVQSALVDVASILDRRIASIEQQLQAAKRGKNKSKADEIQRSLSESNRYRKICNDAIQSFFDTVFVHRYRDVDPRIRVECVEALGNWIWNLPTVFLEPGYLRYLGWMLSDTNAGTRQEVLKQLNRLFKRDTEQLGHFIDRFRPRLIEMATVDADVSVRVAAISVIDSLRAAAILEPNEIDAIGRLIFDSEIRIRKAVVGFFIACVRDVMDVKIDQMGGSDVLEELDLAGDDIYEAPRRDWLNLKCLAETLNTYDRQVEESQRTGGLAVGLDVDLLESTMPETRVSLAAQVLYDKIPEVKSWQILAGYLLYDHTISTKSKSRSKKNNPSEDAFKKAVAPNAVEEKILLDVLGSAIKSTLLQLSEQDKSKKRGPRTEAADAQEELALELATNIPKLLSKYGAEPETAAIVLRLERHLQLDSFQQLRQDTSIYEKLLDEVITQFNRHDDKRVLAEAAAALLHARQFEELEELTDSKLSVLWEVVINSLRSFDAACELSARGNLEEAPLQELSTILTKISQLSSISDCVDFLEIAPSKGDSTSPAIQILVNIVARGEFDQVEGDMDKLEDEVVTLAIKACQFYFMWKTRNLSKQLMSGTGIADEELDSLSVLRQTYRKHLITTLSSRASIDQLRLFATGSLCDLHLTFASLRPVVARPASSASRPGGNEKFKVLVQQIEATLVPELTAIFEGAEKNYAKKAKKDRILNEPAEDEDPVDDEESSDEEDEDETLSREERLAAELKAEKALCELTAKYVLIITADLIEPKGGQVNKLKRRLQRNATKLGHNFKEVVAYLDADKMSKRNSNKKSAKAATAAAPAEKQPQKPALSAETVHDGDDDDDDVEDEIEEDVFDDAAPEEGTREDLRRRGLLDEDPIGDDEDEEQQHDAEKQNDDADDDVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDV1</accession>
    <name>A0A2T4CDV1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase III RPC4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1436941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDV1"/>
    <dbReference type="STRING" id="983965.A0A2T4CDV1"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="55870" checksum="466512409D84D1DA" modified="2018-07-18" version="1">MVRGRTTARGVRRGGAAASSRPQTDADDSNHSQEQPGATSARAARAAASTGRFRPKNVRRDESERDALAQQEQQKASEREADERRARGRSRFRSKRSRGDAMGSRGGAFGRPVAGASGPFSAGMGGPGGSAGGGWFGAGGGGGGGGSFARSGKFEAKSGSGYGFSGEGGFRESRINADKLHAMAHDGDLDSEDEAMLNALHSRTGSVMPMGILRREHKEAPVVVATAAELEAAEKAQANVTGEEESLWVDGEGSLPPVDQPEEGDWKRAARVKKEPTDDAMDLDVDTKPATDEKKQPLAKAKVKKPVAQDPEENMIRTDLSLLASELGAITINGDGEAKGDEPANKDGRLYLFQFPPLLPPLKQVAAPQPRIKVKEEEQHATSLHATPLSGAATPVDLTQQGDGESLSDDDDDEEDEAEERRHGFRTQALSNGGLIGRLNVRRSGKVELDWGGRILEMSPAAGMNFLTTAVIVEESDEKPQNGVTTGESIGMGKIMGRFVLAPIWSEEEDWEVAPEELDIGAVESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE46</accession>
    <name>A0A2T4CE46_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1389726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE46"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="17977" checksum="07BB7BC04999F092" modified="2018-07-18" version="1">MLEETQTAVILDPEPAVATHQAGRIRSLRRLSDNQDTAGEEIFPDSNPGTVCGQSLLMHGDGAKSRAFSFSNNSPRADVSSSDLQARAAAELHEENNSRDAIIKRKKKSKKTGQETLMLHTYVALCSQPPDQYHNYHVKGDAPGWRWFVFAENYSATLQSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE52</accession>
    <name>A0A2T4CE52_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_64700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE52"/>
    <dbReference type="STRING" id="983965.A0A2T4CE52"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="392"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="885" mass="98292" checksum="5D3C0A914412423C" modified="2018-07-18" version="1">MPSRPSSREDFEVAIICALPLEYDAVALLFDEFWDEDGDPYKRAAGDPNNYRTGRIGKHDVVLALLTHMGKVNAASAAAHMRTSYRGLRLVILAGICGGVPFSGQEEILLGDVVISKTLIQYDFGRRYPDEFLRKDTVQDNLRKRDRNTSNLLAMFDTANGRDKLRDKTSQFLKQLQERALGDQSKYDYPGISEDRLFESSYRHKHRNSTICNCSKCHGRRDPVCDEALGLSCDELGCDGDYLVPRKRRRVQDEQDKATTPAIHIGAVASGDTVMKSGEDRDRIAGQEGVIAFEMEGAGVWEEIPCIVVKGVCDYADCHKNKKWQNYAAATAAAASKAILERYIQTERSGVRPVEEPPTCHFLVPFGRNQNFVGRRSILSKLLDTIRPSANKDDCQRTALKGLGGVGKTQLAIEAAYMIRDEHPDCSVFWVPALDSASFESAYSDIGKYLKVTNADDNGAGVKELVKAALSDESSGSWLLIVDNADDVALLLGAAGLSAHLPFSRRGSILFTTRNHEAAVRLDVPSRNIIQVAEMGQDEALSLLQHGLTERQTCNVEATKKLVDLLANLPLAIRQASAFMAAKSISTAEYLELYESDHEDMIDLLSRDFEDRHRYTEVQNPVATTWLISFDQISRNSPLAAEYLKFMSMLAEKDIPKSLLPTAKAIDAIDAIGTLKAYAFIAQREGCWRCLERFEETFGQSHPLTLSIRDDLGITQIARGKLEESEKTFLQTLRLREQSLGEHHPSTMVTKTMIMAGLLLSGNHGKWEEAEKMARHSLELIEKVLGKHHQFTLYGMDSLAAVLHIVGQGEEASKMFQQCLELRKETLGENHPALIASKDLLATMLGCVGQHEEAEKAYREVLEFGEKVLGKDHPSTLDTASYPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEI4</accession>
    <name>A0A2T4CEI4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1107664</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a complex with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEI4"/>
    <dbReference type="STRING" id="983965.A0A2T4CEI4"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="11">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB79987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="273" mass="29090" checksum="846FFD5E33637F66" modified="2018-07-18" version="1">MHFRPVEQSMDGEYLAQGRGGNSGQVATPEDDSGSGSGGVYFSLDDVFGPETEAGSGSGDDIAAVVSSLGGPEHALHPSDMRRLETEHTTAGYREGISAAKERTVQAGFDEGFSLGAAIGLAAGQLLGILEGIDDALKTTPLDRVGDENEESKTASRLLAEAREELSVPKIFSSDYWAPDGNWSYDVNPEANEDDEVLFADVAKAHPLIRKWTDIVDDRVKVWKIDRSVLDESVEDEDGRAEATAADDATTSTTGTAGTITLPPSASRQRLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEK0</accession>
    <name>A0A2T4CEK0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1107658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEK0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015787160" evidence="2">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="174" mass="18675" checksum="20E77375F8E4DC28" modified="2018-07-18" version="1">MGSRVAFLLAGLIFAMITAPDNAVYPWRGGCLLSLLLLSLLALFLFSVAFALCRREAGDGAGCETGRPFGGANTRYAGREKRQWRRPGKELMKDGKPCQKGKVFGFRTSDDGIAKYLGDEHDEKGVVVWVLSEPKGFRDGPTLSKLGRRGLGSGGGKLWDLGGRKGLGGGARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF06</accession>
    <name>A0A2T4CF06_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1435810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF06"/>
    <dbReference type="STRING" id="983965.A0A2T4CF06"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="759" mass="86455" checksum="DB9C8B2CEC1B5FC9" modified="2018-07-18" version="1">MEDRLSPPSKKHRRLASERADSTGHEPSLAEDSITPAPTSAARTSNATSSSSESAESSSESTAPNADPTKQAVRRRPVRKAVNVACESCRKRKIKCNGNRPKCSACETRRIECQYASAYREETISAALKRKYQEENKKTSAYEEFFTALQNCSENDAMTMFSLVRQGVDPGALLRQMKEGDLLLQLSVVPETRRRYQFPYLAAMPHHLQTPDNPYLSSVLYETAFNGVGNQAGQGSALPQRGVASRYQNIYLQPYHAAELLDPLIDHVKPSKWTMVTTDDHLMRTLLRAYILHEYPTFPIFHKDIFFQAMIDEDTQYCSPLLVNALLAEACHSFIGIPNRHQFWVPQSLRYRFLAEAKRLWELESDRVDLVTVQAATLLNLIYSHNGMDKVGQPYLMHALHVAQQLDLFGDHAHERNQRMIHARVFTAWALFNWQWCVSPSPLWHCTILPPLRTYDFATPIQSYYYYRAPLIPDPPATPLPDPDGHPFWYGDFKLRYPLNPTLVPANYGHYFKAVSGLRSIIHDMAAISYSQKEEHSVSPRQIWSVFSRLEKWFLGLPAVLSPRNIVFPWQLKVHMELYLATIMFSTKQAGVSEASTLMKETAQKTAAHAAARLETVARLYYIRHSFEYCDPFLTIHLSFIAGGAMDSLKLTPAHDEDTIKSLKSTIILSLKGLYDQGQHIHLTSVIYRLLRDRLSPEDLALLQNYVVWDPLAPEEPLLVQYAQSHYPLTMGSKHQDPAAARLENLVKQYEKLSTKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF77</accession>
    <name>A0A2T4CF77_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1435887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF77"/>
    <dbReference type="STRING" id="983965.A0A2T4CF77"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="413" mass="45928" checksum="FF640CFC1AFD3DCE" modified="2018-07-18" version="1">MVYVRQRNLPALKEYKYSAVDRSLVSKYILKPFYTNFVIKCFPMNMAPNLITLTGFSFVVLNFLTMLWYNPTLDQDCPSWVYYSWAIGLLLYQTFDAVDGAQARRTKQSGPLGELFDHGVDALNTTLEVLIFAASQNMGQTWKTVATLFASLLTFYVQTWDEYHTKTLTLGIVNGPVEGVLIVAAVFALTGYLGGAHIWQQSAFRALGVPASLGIPDFIYDLTFTDWYMVQGTIVLVFNTVESSINVIRARRARGDRSRGALLGLVPFFAVWALIVTYLYLQPNILHHHLIPFALFAGLVNAYSVGQMITAHLTKMPFPYWNVLGLLIGFGVVDSMGPVMLANYGVGWPSSLGDGVYQTAFVFLMLGTALGVYGSFVVDVIVTICDYLDIWCLTIKHPHDEATAAKPNGIKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFD1</accession>
    <name>A0A2T4CFD1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1369292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFD1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="270" mass="30752" checksum="8518350075D56EF4" modified="2018-07-18" version="1">MAAKSDVYTLHYFPFSLYSLMVRFGLVLGRRLNANTAPHVQIKLVNLHREENLSEEYLTLVNSRGQVPALTSQALASPLTDSRDISNWLCEMQPELVPDSNRTMIQSIMDKLYSFHAMALTVGREEKKHGIPNRAAELLENKDLTEHHRRALEMKSVFHDLCYSDMFTAASIEDVEAKARGFVQELDSALNEYSKGRQLWIFGDRPTILDAHAAALIARLMDVRRQDLLTERVQEYARGVFATEEWNEVTHGRSTLWNVSLGHVADLNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFL6</accession>
    <name>A0A2T4CFL6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1369438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFL6"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="534" mass="59321" checksum="9D398E55DE1D4A3C" modified="2018-07-18" version="1">MEVLEDEPSWGFEPSSSREQIFTKDKPSPLRIVKRRHSNDRYDGRTYTSHYPAVNADANGSPSEPSLIRSDFSPTLNLPRRRPKSAFERNNGFEAEDRTFSACTLPLERNIRLDLSSRASSRCTNYELKDIPNSTNSPFLPDFTRPKESPVVLYPHIRVVSETVGISFGQQHLWAAVEVSGRLSRADDGPDLEPEMMACSDKETVSEFGYLYDVIVDILPTPQSSILQIIGRQEVPATMFVGSSVLLLVHVLCHSGIASPATRQYKHQRQRSEELIEDLEMQLGSSFMSFVNIHVTYSHSAFPSHLGSGGAELSSLYTKLRTSAEATVKLHNALSPWSPHPVMAKGRLLPLIRRHWGAQEASEVMQQMSEQRSVSSPAHTGKVSEGYFQSMTQRLLDPICSPVVLPRRTSTQGTQHMIDEADTEAEPSPVMRLSCDSGIGMRGVSGGEVSVTAKRDQPCDGAKGQGDTVRRRRPVTPVSRNLTPSFSAGNRGVDRNENGHDDQSDKKKDRRKQGATGDNVGKRKSGVWTWASWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFQ5</accession>
    <name>A0A2T4CFQ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF292-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFQ5"/>
    <dbReference type="STRING" id="983965.A0A2T4CFQ5"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="34319" checksum="1F09D6E14FDECDF4" modified="2018-07-18" version="1">MPPAAATWLTKLKVQLKLAIARLRMVQQRDEQLGKTQRRAMAQLLEAGKVDSATIRVENIIRADITSELHELLELYCELLLARAGLMEGPVCDPGLEEAIKSILYAAPKTEIKELMTVRTLLAEKYGKEFVLAAMENADGKVNEKVVKKLNVEAPRKELVQGYLEEIAKAYGVDWPKRERVVSSPPPPELIDGDDLGDEKDGGDPSGGQAQRNGTDRALKAGERKLSLSEQQLDRATPPSAKLGEPKSPLMVTPPRMTTDNVHPKVMMGSVELKSKQDEAEEARKKKAEPEESIPDIGDLERRFAALKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGD2</accession>
    <name>A0A2T4CGD2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGD2"/>
    <dbReference type="OrthoDB" id="3877279at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31931" checksum="66C33070B2B080F7" modified="2018-07-18" version="1">MQRRGNRDVRFADDDDDYEYNRTCFTYRPLSRLPTPPPTLNKPLVVDQSLEDDDTLNPRYRGPAIHLVNLIPASASLATASVSFVQAMLSRAELSMEMLALAVCILDSLDTKFARTWRLSCPLSCPLSTDDIDSPAAASPSLSKRHSLPPRPRDVPQRQLHIDSVRPEIIILAALVIAAKFTQDPQQPPQFYRLAWGRGLWSNEQLNVTERCIMESLDYRILPLCEDDCLTDAMVDMQLAAELETGPRWNVARQPTPPDSAAGSDCEFVPSHNRSKTTVGFAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGE4</accession>
    <name>A0A2T4CGE4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-alpha protein subclass III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1324423</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGE4"/>
    <dbReference type="STRING" id="983965.A0A2T4CGE4"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB80637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="40892" checksum="9E4051648BED526E" modified="2018-07-18" version="1">MGGCMSHNNDEVEQKKRSQAIDKELDEDSKRLRKECKILLLGSGESGKSTIVKQMKIIHLKGYSEEELYNYRPTVFKNLVECAKAVITAMQQFNIELEKEANRAYADFLVNYQPESGPQAHIDPQVGLAVQAIWSDPAKDQLMEHQTEFYLMDSAEYFFQEAMRIVAADYLPNEMDVLRARTKTTGIYETRFQMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLLLFDSVVNSRWFMRTSIILFLNKVDIFKQKLGRSPLSNYFPDYTGGTDVNKAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILNNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGS6</accession>
    <name>A0A2T4CGS6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1134017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGS6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="185" mass="20076" checksum="9B88549C664A1A22" modified="2018-07-18" version="1">MVGIRRAGGSRQPRGATLGKDEARSSPRSAEKEAPGEDVRTVGETCRREAHKAAQCGVARRPPYEGGGGGCDDKVSDRTAGGYRGFDADVKMMAIFGGDASLPMRVSVVDAMAEVATADKMSEIRSGEKGRAEVKEEEEEQEERERRGIMLAFGLPDAVCRFEQRRWTALGETRRRLCLFVPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGZ2</accession>
    <name>A0A2T4CGZ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_46923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGZ2"/>
    <dbReference type="STRING" id="983965.A0A2T4CGZ2"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="414"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="504" mass="54848" checksum="17A60AC132B5CBD8" modified="2018-07-18" version="1">MRRSLSTRRNFSVSQCLARQADAPFRMAVVGSGPAGFYTAYRVMSKLPQARVDMYEALPVPFGLVRHGVAPDHPEVKNCQEKFDEVAASPNFTFIGNASIGHPGHLEEHCTIPLKVLMSHYDSVLFSYGAAEDKKLHIPGEASLKGIYSARQFVGWYNGHPDCGQLEPDLSRAEEAVIIGQGNVALDVARILLEDVDVLRKTDISDRALAQLAESRIKRAHVVGRRGPMQAAFTIKEVRELMNLSGVAFHGIDDSLVPPALDKLPRAAKRLMEVLRKGTAAQVSETPKSWSLDSCLSPKAFVGDKRNPSRVGSTEFYVTKLEDPFSPQSSVALTEETRTLPSDIAFRSVGYKSVPLPGFAEVGIQFDEKRGVIRNDGLGRATQVLPGLSEPSGTPPITLPGVYCAGWVKRGPTGVIASTMRDAFMTGDAVVEDWLSGAPFLNHPAEGKAGGWDAVKADVGAQADQVVTWDQWRQIDQAETARGATRGKPREKFTSVRDMLGTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH03</accession>
    <name>A0A2T4CH03_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 17">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1398155</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 17"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH03"/>
    <dbReference type="STRING" id="983965.A0A2T4CH03"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="20">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="356"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB80792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="459" mass="50248" checksum="2D9EF2C4A332D232" modified="2018-07-18" version="1">MASSDDVPDSTDWLSTPLSGFAAVEAALRCQVCKDLYKTPMITSCCHTFCSLCIRRALSNDGRCPMCRATEQELKLRSNWSMEETVEAFSKARAAALSLARSQHQDGPPRSSRSSPKRKAGEMPAEAHEPPKRLRTSARLSRNNRGEEASVPVAPAEEVEEQVVPASNNDDEDEDYVPDAPNGLVPCPLCNRKMKEWQVFGHLESCPGPSAAASPSRNNINPSDTAPSFAQSHRKPQKTLERLPPLNYSMLKEQALRKKMSDLGISSQGPRALLEKRHKEWLTIWNANCDAAMPKKRSELLHDLETWERTQGGRAPTMGRVAQTAAVIKDKDFDGAAWAARHDSSFRDLIANARRSRETATKKTEEVDKVVDEASEGSAGRNPEPVVVSSSQPHDGVPATTDGSSGQDRDRRLETAPGLDSVLSPPHAEPMSWELSQRPIGSTSSAEGASTRIAEADKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH67</accession>
    <name>A0A2T4CH67_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_70769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH67"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="103" mass="12125" checksum="472170F39AA686DB" modified="2018-07-18" version="1">MYARNHLCSPQISSSNRSKRDISTHRCCRKHLPVVQSIHHASLTCTTTILSCHEDLPCQSPFPFLFPHRKPQPQPQSQTCVRERDFRHKRRIRQLWLLPKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI47</accession>
    <name>A0A2T4CI47_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sister chromatid cohesion protein Ctf8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1321338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI47"/>
    <dbReference type="STRING" id="983965.A0A2T4CI47"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16455" checksum="96E8FADF72D623BB" modified="2018-07-18" version="1">MSSSTAKLYPHPKHSSPTPNPLPKLLQTPSGLAILELQGTINLPQDAHGEALKDVEVGRLEFPDYAPDAVGSAWMKRVHMYVGQHQRLTGEVKKLPKALAVVRRRQSRTLEGSGGVCVEEGGDNLEVVEIVKYKLMFGSRPEPVGTAHAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIH8</accession>
    <name>A0A2T4CIH8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1321441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIH8"/>
    <dbReference type="STRING" id="983965.A0A2T4CIH8"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="220" mass="22706" checksum="2A9A3583CC0A6364" modified="2018-07-18" version="1">MKPIVVTVAAAALASGLSKHSTAANPPQTLDRVWSGVKQSGSGFTSVTGTFTIPKGGKSFGPSIWVGIDESTECPGGGLLQTGVRLTGNGTAFGWFEWVPLSAPVFEDFKVSEGDDVRMTVHAYGPLNGSAVLDILSTGQTWIVEDYNNSGGNDTGIVASPDYGTITIRNASAQGSAGTVTPEGGELIALFDTRISTVLSQCSAEKEEVTCEYAGPPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIY5</accession>
    <name>A0A2T4CIY5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1346461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIY5"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="23512" checksum="D96266C0938638F2" modified="2018-07-18" version="1" fragment="single">MASPDNSISTPPTSLASYDQEQPPTTQFTTIKELCQVARQASGDYLVIQNVSPTNFEEIICQERRPFRIRRYHADRKILIVTIPTVLHEKLHLELYETFHEQLWPRRREIWTQIGSTTFRPQGHPGGDGGEGDSCGGPKPARNHPVAWPTLVIEAGDSESLTALRDDMRWWFTASDHQVKIVLLSKFNHQRQQIIIERWEEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJF4</accession>
    <name>A0A2T4CJF4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_90695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJF4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="192" mass="21903" checksum="506625E8AEF74DC9" modified="2018-07-18" version="1">MLRFKDRQSYTREPSTTMNGLMLSPSRLHHLCRDSRTCPSTIYGHHGQFSHDGGLNLVNEKHERPTCNNASTEIDNPPPMRGKPASKHPKHLYREHLTKENSHYLTNIAFALPPRIAPNPSHGSNASQNFISIISLPPPGETREEQRSIRLSHGEPWGSTKKKKEMEYPSQRKKHIAKAPIGNLFFLRSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJI0</accession>
    <name>A0A2T4CJI0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1322037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJI0"/>
    <dbReference type="STRING" id="983965.A0A2T4CJI0"/>
    <dbReference type="OrthoDB" id="4487429at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="19902" checksum="FD9299F031C114A2" modified="2018-07-18" version="1">MEPEWSDYLRNYDGRHPELRAEFALGPGGFVRGWPSKGGIYVLSHVFGVELEFLGLDRFNNTARPSISDPAAAAEEEEAHCNKMRQLGAKWYENEEEYRFSNVAPELFDLDIKYVGWPAGGGVWVLLLVSRSYARMQGTAVIQNAFNMEERCMAIEQLGGRFYENPKDCPFLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJP2</accession>
    <name>A0A2T4CJP2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1023942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJP2"/>
    <dbReference type="OrthoDB" id="640151at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="569" mass="63881" checksum="0CDD49054B774668" modified="2018-07-18" version="1">MAFLWCQPLSHQSYWGEFDLRGLKIKIKSPKKDVFRDDSGQIPPYFWAKGFRNRVRKLLGRKPRKHSFPIHHGYSEARELVGHGTVPELAMLSNQARKFVAEVFADVGDASETSSVGDKQSLSSLESGPRVVQLRLSADLQAWKESQHAAGNILPPKGTGLSQASAGALQKFGAAGWPDALKTNNALFGCGIASMLMGAADAPTMFSNYVTDMVFYYEHGYNYVFPTLEPLLQKGLEDPHALRTPGGRERRDAVSLGKQYIQGKIALEDRFKKNLSYRSARLNRRTAQIVSLSESSLLGMAAEAIARGCDPGAVMADLVFSSPGTDVVDVGCDLVNSEVMNSFLNVTDITETGIVSEEVLRRVYDAYAATGARMLTQRWHEPVARMCAALYTWHIQNDRHMFFRRAILGWPKARKAPNQPQFEADFDEVFDKQYRTTGFSRPLDAKYACNGEDTCDHVHQFFHRHQDKPLLKDLWRFLVTEPLAYVRGGVVDEECEYEFAEGSRLTMADLFSRGQVLEMVWIIAHANHHAWQVNHLFEAAMFGSILDGGKLIGKLDRQEKKPLQEKDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJU8</accession>
    <name>A0A2T4CJU8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJU8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015636431" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10906" checksum="7BE33393F6CB1BB0" modified="2018-07-18" version="1">MGSPPRLRFLVTLSVPLLSADAPPPRLHLMPFLSLPVTIPIPASVYKSTHCPAANGRFCLGSPHHSFLARRVFMGPRFEYLKTPRQGFYPQDHWDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP26</accession>
    <name>A0A2T4BP26_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1426831</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP26"/>
    <dbReference type="STRING" id="983965.A0A2T4BP26"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF116">
        <property type="entry name" value="PROTEIN METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="19">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="18">
        <location>
            <begin position="249"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="20">
        <location>
            <begin position="352"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB71075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="553" mass="61337" checksum="AA13A8F38671252E" modified="2018-07-18" version="1">MSARSVSESSSASSNVSDEGEWLDVENDEEEAIPVVSLFDNQRTFPSWAEMLDSCKREHGFDLVATIRDLKLDFHGAVKLVNFVRSRVRDGQPLPQPLAPADFEDDAFFKPVLDGDALIVALDEILDSDLVKAGNGGGDAAAAAAAQLDGSREELLTQKQALEAELEAVRTQFSNYRLAVQETLDRRWGDDEEPSPAKGKAGGEDRGNYYFESYAYNDIHETMLKDTVRTEAYRDFIYNNKDIFKGKVVLDIGCGTGILSMFCAKAGAARVIAVDKSDIIKKATENIFNNGLSDVITCVKGGIEDVKLPVDQVDIIVSEWMGYCLLYEAMLPSVLYARDRYLKPDGLLVPSSATLWMAPVQDSDYMMEHISYWRDVYGFDMKAMQEGIFDEVRVEAVPKSALSGEPYPFKVLDLHTVKPEELSFTANWESRLSRPSEGLDGFLIWFDNFFATSRAEPVPEPFTTPEDFIKAKPGNVAFTTGPSGTVTHWKQGLLLVPQGSTPSKLPETISGQVTFAALEENARALRVDVTCSFDGQPVASQEKKEKKWSWKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP35</accession>
    <name>A0A2T4BP35_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1387345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP35"/>
    <dbReference type="STRING" id="983965.A0A2T4BP35"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="690" mass="74497" checksum="00CF2AE038DF30BA" modified="2018-07-18" version="1">MTPPLPQGRSFTVRGVAAGLAVGTVICAANMYFGLQTGWVSIMSMPSSLMGFAVFKLLKPYLRFPFSPVENVLVQSVAGGMAIMPLGCGFVGVIPAMNYLLEADEQGPLSLSTWQLIIWSLGLCYFGVVFAVPLRHQVIIRERLRFPSGFSTAVLIRVLHSQGQSSSPKELDAAAKGGFASLVPKDDDPMLVDEGGSVAEEEEPTAPKDLDWAYNMRLLLLSFLVSGIFTVCNYFLPILRDLPVFGTVAASTWLWTLNPSLAYVGQGIIMGTETTLHMTLGAVVGWGILSPLAKMKGWAPGPVDDWENGSKGWIVWVSLAIMLVDAVVSLAYIAFRPIFETHAVKLASVLKRQFRHGRIAALFGSAHRYAPIPAQEERDEAEDENQFSTLRDDQSSVVEEEDDGLDDAPVDQQVGSRIVSWGLLASVLVCILATRIVFGDLVPLYAIAIAVLMALVLSIMGVRALGETDLNPVSGISKLAQLFFALIIPQSHKSSVLINLVAGAISEAGALQAGDLMQDLKTGHLLGAAPKAQFWGQIIGATFGAVFSAFAYHIYTAVYEIPGKLFQVPTAYVWIFTARLVTGQGLPYMAKEWATGAGALFAVTTLARTLSVGRPWRSWIPGGIAVAVGMYNVPSFTLARAIGGIISWYWLSIRKQSTTPLIIVASGFILGEGFLSILNLWLQALKVPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPG5</accession>
    <name>A0A2T4BPG5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fms interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1395830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPG5"/>
    <dbReference type="STRING" id="983965.A0A2T4BPG5"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24365" checksum="4040B216A59F8EA5" modified="2018-07-18" version="1">MAVEKIVTEPSLAAVLQISDQARDQAHALLQLADRASDGRASAEAQAEIAKQQKQLFTNISHLRGLHRSACLSARDTKAQTAEARQEVDRLHLQLQNLYYEQRHLQGEITGCESYDHKYQQLPLIPLEEFLALKPEYKDSTDDERMFARIEHEREEREILEQRRQELLKRKQKLIAENKRRKDDLANLDQDLEKFIDAAKPILELFEKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPN1</accession>
    <name>A0A2T4BPN1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dabb-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1406631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPN1"/>
    <dbReference type="STRING" id="983965.A0A2T4BPN1"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="12043" checksum="B62ABF29E8223BAE" modified="2018-07-18" version="1">MSITHTVLFQIRADAKPEDVKAACDRFLALKDNCIHPTTNSPYIASLKGGQDNSPEGLQNGITHGFVVEFNSAEDRDYYVRTDPAHQAFVKSIGGLVEKAIVVDFSNGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPX4</accession>
    <name>A0A2T4BPX4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1466320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPX4"/>
    <dbReference type="STRING" id="983965.A0A2T4BPX4"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015693996" description="GOLD domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21631" checksum="6A465D633A09808E" modified="2018-07-18" version="1">MRFSPALAALLGATLAEAQFLISELSFGYAGRISPAENPGHIPNFIVSGQPSMPEILSSKVILTPVAPGNARGAIWSEQPLLHSNWIVDRHAEVKELFASLQSKLALLDQLAAFQQRIVALENEVRNMNSELQQKIAANERAVHGALRTHHMSLTQRVTESVPGHGRLIAVIVGTQVVLVAAYVLYKRKKANSPKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ31</accession>
    <name>A0A2T4BQ31_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1365783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ31"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ31"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="7">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="240" mass="27305" checksum="30B74B61F2712458" modified="2018-07-18" version="1">MFKQSPQRLSQLQAAVPWAARKTPALGCMINESRSRNYSAPARSDRDKTSSIRSPRSLQALHLKPLKREAEYGIPSCDLQLRSFSLQPLQFFSDFALRAAYYLGLPASGPVTLPRITERWTVPRSHFIFKKSQENFERVTLRRLIQIKDGNPETVQLWLAYLRKHQFYGIGMKANMWEFGTTETSKSLDEIEALTSGQDAPWSHLGQTRSIGAADKVVDILNSRRVKKAADNNFPIHEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ99</accession>
    <name>A0A2T4BQ99_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_214561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ99"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="14560" checksum="92CDDEE0D91AC5B0" modified="2018-07-18" version="1">MASVLLRAGTTWDIYWSKQHAVLWLLALTDSSREEEIDDCLAFLFPANLFCFYISPFSPPLALLYIYDTTLESLPVHIHFITSCTIIISCFLHGGIHRHRRIHHTHTQRHTHREREEMAYTHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR30</accession>
    <name>A0A2T4BR30_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1434316</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR30"/>
    <dbReference type="STRING" id="983965.A0A2T4BR30"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF28">
        <property type="entry name" value="BETA-GLUCOSIDASE L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015488964" description="Beta-glucosidase cel3A" evidence="18">
        <location>
            <begin position="20"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="662"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB71768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="744" mass="78200" checksum="699D42A2219D388B" modified="2018-07-18" version="1">MHYRTAAALALAAAPFVTADSSSTSRAPAEAAVPPAGTPWGTAYDKAKAALAKLSLQDKVGIVSGVGWNGGPCVGNTSPASAISYPSLCLQDGPLGVRYSTGSTAFTPGIQAASTWDINLIRERGQFIGEEVKASGIHVILGPVAGPLGKTPQGGRNWEGFGVDPYLTGIAMGQTINGIQSVGVQATAKHYILNEQELSRDTISSNPDDRTLHELYTWPFADAVQANVASVMCSYNKVNTTWACEDQYTLQTVLKDQLGFPGYVMTDWNAQHTTVQSANAGLDMSMPGTDFNGNNRLWGPALTNAVNGNQVPTSRVDDMVTRILAAWYLTGQDQAGYPSFDINRNVQGNHRTNVRAIARDGIVLLMNDANVLPLKKPASIAVIGSAAVIGNHASNSPSCSDKGCNNGALGMGWGSGAVNYPYFVAPYDAINTRASSQGTQVTLSNTDDTSSGASAARGKDVAIVFITADSGEGYITVEGNAGDRNNLDPWHNGNALVQAVAGANSNVIVVVHSVGAIILEQILALPQVKAVVWAGLPSQESGNALVDVLWGDVSPSGKLVYTIAKSPNDYNTRIVSGGSDSFSEGLFIDYKHFDDANITPRYEFGFGLSYTKFNYSRLSVLSTAKSGPATGAVVPGGPSDLFQNVATVTVDIANSGQVTGAEVAQLYITYPPSAPRTPPKQLRGFAKLNLTPGQSGTATFNIRRRDLSYWDTTSQKWVVPSGSFGISVGASSRDIRLTGTLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRN3</accession>
    <name>A0A2T4BRN3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1364561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRN3"/>
    <dbReference type="STRING" id="983965.A0A2T4BRN3"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="129"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="300" mass="33863" checksum="3973D11DAE637271" modified="2018-07-18" version="1">MAQPSSVFLWVLDTRPLWPEASNTKDLPQVASRALSLLSPTEQSAALKYHFLKDAKLSLASSLLKRLAISHFLRVPLPRATPVRDARTKPIFIHPPQSNLQPLLFNVSHQAGVVVLFGAHNPPAPDIAIGVDVVCPGERRERDVRHVQTEGWPSFVAMHAEVLSPLEVRRMRELPFSPRAEPQRLLDYFYADWCLREAYVKMTGEALLAPWLHDLEMRYFAPPGETPPEGADKELEVWFRGERLEDVDVKLESALDDEYMICTVVKRGEGGVGLEVPAPEILDLEETLRRAERLLEELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS82</accession>
    <name>A0A2T4BS82_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1688-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1100630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS82"/>
    <dbReference type="STRING" id="983965.A0A2T4BS82"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="433" mass="47765" checksum="0D76DC8437F43639" modified="2018-07-18" version="1">MAATLESDIQYLKSLRAVRERSRIVLEAARNGGLNNFELDELRMKETAEFVAGVISRDFGPDRYAEIPPHGRWEHFSIGGIPRLENLVQKWQDSEVPDVEITRRLIDLFFVSVLLDAGAGDTWAFREPGGDKAYGRSEGIAVASLYMFNDGAFASPTVGIKATVDGHALSKLTEDAFIQHFQVGPQNPIVGAASRIELLNSFGKSLLSLPEIFGTNGRPGLLVDHLLAVSKDNDLDYEALWDILQKLLLPAWPSNRPRINGQPIGDAWPLRVLQERSGDSENPTAGIHPFHKLTQWLGYSLTVPFMKVLKRNWINIDKGTGLPEYRNGGLFVDMGVLKLKPEVLAKGLEASGQKLPLFSSTGDVIVEWRAMTVALLDELHKHVNDILAPQGVSLSLPQLLEAGSWKSGRELAAKHRPETRSSPILIDGDGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSH2</accession>
    <name>A0A2T4BSH2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSH2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18310" checksum="2C2824C3F453293B" modified="2018-07-18" version="1">MSTALIQAPSSEHHDASPTTSHHALATVTRTMCSFRVSSSCTSLVFYALPTAPHRCIQYSPSRQPAGKTPLFIVNRNQKAPAQHQTTSQVHLLLTSKSPQPGPSMARLRRARILLLQFLLVNRSNNHKTRPLVCPSSPRAEARIQRGPSRLLVPSSSHGSWMFTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSK9</accession>
    <name>A0A2T4BSK9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1384874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSK9"/>
    <dbReference type="OrthoDB" id="4899581at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="18620" checksum="C5EFC964FDBE6D1B" modified="2018-07-18" version="1">MTKSNRLPKQNHHRSRPQRRDDNNYINSRHFLQASNQEPASDPHDSAEYDTCSGYESAPGYDSSLDNSSEYDPYFGCSSSSGAPSSFGSRAASPDSEAPDEGIDGPIADSNSPHRHLVRKERIAQNRGSGATSNAAADAKDSQFNGSPSVASKPSTASFAPVGAGAFSSSRFSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSW1</accession>
    <name>A0A2T4BSW1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1341727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSW1"/>
    <dbReference type="OrthoDB" id="4874137at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="392" mass="44852" checksum="9364FDFD6DB3BEF2" modified="2018-07-18" version="1">MKLPFAQPVLPPTPLKSPISIPWTVTFERPRVIHTISDHPKRSIDHLPPEIICMVMGNLTSRFDLRNLAASSFYLAAVLSQHKISILKTMLGKMLDPSNLDICLVTMGILQVTRKGDDVWQCLWALSQRPTLDTIHDAETLCNMLDLTLYIEYMLTIYTYPKHPDSFWRRALRKYANRWPDGNVPDGYVSIDSVTKQELRQVASRLWNVRDAALGNSPDAEPRAKHSDELMTLFQREMFSAELKLRCDLVAGLGHDVPEWMSEEAPGDGVQSFLELLVHAMAGCWNRDDGEVWTEMNRSSWAEGRALGIRFYICLAMYMPQSASADDVDEICTAIDCFMSYYRTPGIYGEAYQWFFEFQDAAWPGLWEHTREFCRLLDEGLVDDIDGGTDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT91</accession>
    <name>A0A2T4BT91_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_22408</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT91"/>
    <dbReference type="STRING" id="983965.A0A2T4BT91"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="501" mass="57959" checksum="E7DDFB52A0D587FC" modified="2018-07-18" version="1">MMRQDYSRIDPKRRNVVDYRKKQFATPQFKETQYPHRLNFYADAPTADITLEQFEQWAIDRLRVLAELEACSFRNRSPAETASHMKPILDKYLPLDSNSSSNAKLLHSQRQKDHYSHFILRLAFSSTEDLRRRFARVETMLFRLRFNSDDLKERAAFVSSLDLDWWDPVTDDEKRRYAAELEAMVSGKKTSSEDEMWFKVDWERVPDLVESRRVFLKAGKAYVPGREQSSMVVAEFTSRLERQLELTARALPRLDEDDRLTPILNHLSKNFITPDASYISGSTAPAGAQFSAANVDNLSQHFPACMSNLHRSLRRDAHLKHYGRLQYTLFLKGIGLNLEECLAFWRGAFHKVTDDTFNKEYRYNIRHAYGDVGGDSNRRGGGYSPFSCQKILTEHPPGPGEAHGCPYRHFNLENLTSLVQAMGVTDRSVLQGVKEDKDNQKFHMACNRVFDHLHKAEIKKAKDEGIMTSNQLETIVHPNEYFKRSYLLKNLGKESDVKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTA4</accession>
    <name>A0A2T4BTA4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1425649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTA4"/>
    <dbReference type="STRING" id="983965.A0A2T4BTA4"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="205" mass="22866" checksum="7960734BD6411B24" modified="2018-07-18" version="1">MAAKLSADLLFQMAKTRRSIYTLNKDLPISTSRIHEIVKEATLHTPSSFNVQTNRAVVLFGAEHEKLWDITHDTLKAIVPAEQFQSTADKLKLFKGGAGTVLFFEDTDATKALQAKYPLYAERFPPWAAQSLGMEQLLVWTALEVEGLGANLQHYNPLIDLKVAETWKVPAHWRLDAQLVFGGKAGEAGPKDFQDIDERVKVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTL6</accession>
    <name>A0A2T4BTL6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1441566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTL6"/>
    <dbReference type="STRING" id="983965.A0A2T4BTL6"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="192" mass="21254" checksum="4CED3AD8EDB0126A" modified="2018-07-18" version="1">MSSLEEASPLGAQWFSVGLASTFPDLGHDEDNLAKYRACGGPELRPGCRVFQVPRDDSSQRAEIEIREDGTLQRSEMKGLKDQVLVFQYKGKFHAVDHKCPHSLYPLSQGTPFDIEDFGIVFSAGLTCPKHGWSFDLFNGAADRGSYELGVWETQLRDVKSSEESPEASGGASQSSVSVGKEVWVRRRQRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTP4</accession>
    <name>A0A2T4BTP4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isomerase YbhE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1441581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTP4"/>
    <dbReference type="OrthoDB" id="10044505at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051200">
        <property type="entry name" value="Host-pathogen_enzymatic-act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197:SF3">
        <property type="entry name" value="DIHYDRO-HEME D1 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197">
        <property type="entry name" value="PROTEIN NIRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015536051" evidence="1">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="480" mass="51019" checksum="D198981C38C70CB6" modified="2018-07-18" version="1">MPSYTQLSLLALGLLSGLASAWDQAPALAGRGAPISDSDRLYTGDQSSNTITVIKPMTGEVLGTISLGDSRLSNDLNPQYVKVVNSHGLGFSPDGKLIVSLAVTSNTVTVFRAEDNAVVSQTPVDRNAHEAFFERDNRHVWVGTRGVDRIDIVDGLKGGVVGYVQSYGGPSKVVFSPDGRTAYANHVRSPSLSVIDVARRRVVANITGLGDVFSSDMMISPDGKRLWTAHKMVGKVTVIDLVRRRVVGVMDTGAETNHPNFAVINGTMHGFVTVASTNQTLMYAQPDSGKMPVFLGGIPASGVEPHGLWPSADNTHLYVVNEHSDTVDFIDLTVSPPKVVKTVNVGQEGQAIIYVSGAVSAASNGTQNLGRQGLFDKPALNKILTEVQPQSSSKTPASCLVTVRPEVGLDMFQVIGRNLAFNTTYTVSATMADRLIPLVDFNATAPMGDGCGTAPQVLAFFKFIGVYEVDDLVLTSKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTS4</accession>
    <name>A0A2T4BTS4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1441559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTS4"/>
    <dbReference type="STRING" id="983965.A0A2T4BTS4"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF169">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="279"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="723" mass="77884" checksum="F5F2E610A60E31C3" modified="2018-07-18" version="1">MASETKATLPNDGPHAFTFPPPTTAFIVINMQQDFLNSSGFGSGNPAISSSVRRIVLNICRALHAARRLGLHIVYTREGHLPDLADLPAAKRLRHAKASNAGQPIGMGDEVPMDGLLVRGQKGHDIIDELKPWAADLVVDKLGTGTFWSTGLHRVLLARGITHLILTGVATECCVSSMLREGPDRGYQCCVYLDCFTGFGEMAARSLDILRRQVGLFGYVSHAPELIARAVQHNNRAKPSLSYANLAQTALPPISRLRDLYQDSLLDPEMFMRNVLKRIATYDTINPAVWTSRPDPEETLAVARNLSTAYYMNSSKSMPPLFGIPFAVKDNIDVEGQVTTAACDSIAYTPTSTAPAIQHLIDAGAIYVGKLNLDQLATGLTGCRSPYGTPHSYHSEKHVSGGSSSGSAVAVAAGLVSFAVGTDTAGSVRVPAAFNGVVGFKPTKGTISARGVVPACRSLDTIGILAPSLEDARQVWYVMDQYDPSDPYAKPQESLPTWPVDYRGPREGGFTFGIPPESVIGLCCAKYQELYRRAVETLQSCGGTLVDIDYTPFATAGDLIYGASLVHERLASIGYDLISKNIDTFHPATKAIFQGLLSSNVSAWEVFRDQATQMQCTAGARKAFNKLEGGIDVLVVPTVPFHPTIEQVLESPLELHSELGVFTHPANVVDLCGVSVNAGWVEEGETRLPFGITFLGGSGYDGKVLDIAAVFEQSSRKREDRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV24</accession>
    <name>A0A2T4BV24_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sof1-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_7553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV24"/>
    <dbReference type="STRING" id="983965.A0A2T4BV24"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sof1-like protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="59" mass="7249" checksum="306E8D0661803746" modified="2018-07-18" version="1" fragment="single">INRIRRHRHMPKVVKKAAEIKNEELKSIKRREENERKHSSKQFQARKSEREKMVLAQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVY2</accession>
    <name>A0A2T4BVY2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1424765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVY2"/>
    <dbReference type="STRING" id="983965.A0A2T4BVY2"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="94"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="617" mass="66185" checksum="37DDFABACC6CD9BD" modified="2018-07-18" version="1">MAGDQATTPDRRTSSDETVHPARSTDGEIKAFEAGDGVDKELGDGEIGVSSVGLEDEAPASTSPKAAEAGGPPAQQHPADEPEASRTKIETFLIIFALCLALFLAALDMTIITTAIPTISNHFGSSAGYVWIGSAYLLGNAAFVPTWGKISDIFGRKPTLIATVTIFWIGSLLCAVSTSMGMLIAARAIQGVGGGGTIVLPNICISDLFSMRKRGMYFGILGMVWALASAIGPILGGVFTSKVSWRWCFYINLPLGGIGLLILIFVLKLHNPRTPVKQGLAAIDWVGNALIIGGTLMLLFGLEFGGVQFPWKSATVICLIVFGFITIALFSLYENRVAKIPVMPTRLFRDRTSIAAYGLSIMHAMTFMSGSYWLPLYFQAVLGATSLLSGVYILPYVLALSITSALTGVFIKKTGNYKIPIMSGLTIMTLGFGLFIDLGPKANWAKIIIFQIIAGVGVGPNFQSPLIALQTNVEPRDIGAATASFQFLRQLGTSTSVVIGGVIFDNEMQKQQAYLIRELGPELASKLSGSEAASSVFLVASLKGHQREVAQTAYWNAMQKMFIAYTCFVFVGLLISFFVKQKTLSKQHTEHKTGLSSLKQETKKKPTDVEKAVDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW05</accession>
    <name>A0A2T4BW05_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1063031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW05"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="267" mass="29948" checksum="92B933440CEDCFFB" modified="2018-07-18" version="1">MTRPVPPGYPVSGWSATRYGGRSSCCGAFVSRHGAMEPDGVAVVVGKARQLSCIVLQAVYANKQQQVASRHDKGSAGRTPRIETSANCRLTCSRRVPVGSSRLIRAFHTGASQELPSSYRQRTARRGGHSIWRDERRCKEHRSIQSIKRPRSKAMSHRDWPGVPFAPFRLLPRPTDSWTQPPWRRCSSGWDFPALASLAPHNVSIELVVRESMSWVLLWTKWRFSLCAAVSICRAGGELHNGLIICKMLRTSHERHSRGRQKGDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW43</accession>
    <name>A0A2T4BW43_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1404538</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW43"/>
    <dbReference type="STRING" id="983965.A0A2T4BW43"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="18">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="19">
        <location>
            <begin position="139"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB73539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="293" mass="33419" checksum="23EFBE82BCE328C8" modified="2018-07-18" version="1">MANSKFEYVRNFEQPDPLLPNTWIVVRIDGRGFTKMCAKYEFEKPNDRRALDLMNAAAKAVVTDLPEITIAYGVSDEYSFVFHKSCNLFERRESKLVSTVVSTFTANYVYFWPTYFPDTPLSLPLPTFDGRAVCYPAVQNLRDYMSWRQADCHINNLYNTAFWKLIQLGGLDNKEAEKTLAGTLAADKNEILFSRFHINYNNEPEIFRKGSVIFRDYELAEPGSHNAAAAADALAEPGVQSKSQAEKDKKRRAKAKVVVEHVDIIKDEFWDRRPWILSGKPGQPGKASKEIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWI9</accession>
    <name>A0A2T4BWI9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1066849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWI9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="218" mass="23496" checksum="48755E9798317FC3" modified="2018-07-18" version="1">MASQVEEIEFGVETSGAITAFGSTKETSSRGRSRGGRLDEGTRAGRTQTRTQTQTQDTKIQTRPRVEGTIRSEWRASGRVGRRQAGGGTLKGAMTEAHRGGSTETSTMHVSLQPTMVSGGRGGEAGKERRAMRQREKGRKGKVKKDSDLLLAGACGVGWPGLRDNERVEDWKGKKNQKRQRFSGGDGACGSRTVLVPGPSDRPSPRHSHEAISPPRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWZ1</accession>
    <name>A0A2T4BWZ1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal homeostatis protein bsd2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1393713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWZ1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWZ1"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35759" checksum="0F239F4AA7D1F84F" modified="2018-07-18" version="1">MSGRYERVNAHDEDEEHDVPQRRAQIPNSPPPSFHSRASSPTRNGRVNNDLADAFDDDDASDDDEADDRQRLVRQNSTPTIRSADTARSSAPTAPAPAPTTTDNASSGSRPRVMGGGVGTDGVFANMSARPERTDANAEKEEQPPSYEQAAADAAPPYWETTILAPGYGGADEVYVDGMPVGSVFSFIWNGMISTSFQLVGFLLTYLLHSTHAAKNGSRAGLGITLIQYGFYMRETPDEAPTMTGPDGYAAPPDPNSHNFDPDDVRDDGSGISGNDWMAYILMIVGWFLLIRSVAEYMRARRHEQLVLQSPDRGLGVPIIAEGESSEHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX85</accession>
    <name>A0A2T4BX85_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1055920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX85"/>
    <dbReference type="STRING" id="983965.A0A2T4BX85"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="381" mass="41543" checksum="15884BAEA1E5675B" modified="2018-07-18" version="1">MAPIRTAIIGLSGNAITSWASAAHLPYLLSARGREKYQIVALCNSSVEAAKRAIEVFKLPPETKAYGDPQAVADDKDIDLVVVSTRVDVHHSSALPSVKAGKDVFVEWPLAQDVAHAKELVDAARAAGGRTLVGHQGREAPPVVKVRQLIEQGTIGKILSSEIRAYGGALDRESLRPGLKYFLEKKVGGNIVTIGVGHLFDQIQHVIGDLQNIQPHLQLQRPNVLLRDSATKEVVEVVKSDVPDLIIFNGNLAASQKAVEGANVLFRFRRGQAFPGEPGLTWAINGEKGEIRLQAFSGATLHANSYDAPVTLEVHDFASDKVEKVDWSWQDWQEALPVVGRSIAVLYDKFADGPFEGQPTFETALVRHEQLETILADWDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXD1</accession>
    <name>A0A2T4BXD1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_365073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXD1"/>
    <dbReference type="STRING" id="983965.A0A2T4BXD1"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="167" mass="18055" checksum="AA9CCB4292BA2C3B" modified="2018-07-18" version="1">MPSILNIAHMCSHLQNASKARLGLTSIPSTKYNLHLALALHRSGFFSSVYRSPGTQPPTPEQMVAQVPAPVTTATVSQMRIWLGLKYWDGRPVLSKAQVISKPSRQLTVDVDELGRLTRGFPTKLKGGVVQGLGVGECMFVSTSRGVLEAREALARKVGGVLMCRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXQ9</accession>
    <name>A0A2T4BXQ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1058362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXQ9"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="52"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="358" mass="39237" checksum="E9C5D8B10BFC9691" modified="2018-07-18" version="1">MSRNSQDVALLSPDERDLKPDDLEAGKSHGDSKDQNLDHEYSIPSAVKFTWLGTYFFFSLVLTLYNKLVLGKFHFPWLLTFLHTLFASLGTYAMLQMGYFKLSRLGRRENLALVAFSALFTANIAVSNLSLAMVSVPFYQTMRMLCPIFTILIFRVWYGRTYSTMTYLSLVPLIIGATMTTAGEMSFSDAGFLLTILGVILAALKTVVTNRFMTGSLALPPVEFLMRMSPLAALQALACATATGEVAAFREQVRTGGFNPVSSSLSLAGNGFLALLLNISSFNTNKLAGALTMTVCGNLKQCLTVMLGIFLFNVTVDFLNGAGMAVTMVGAAIYSKAELDNKNRKKKQEAAFKPTEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXS3</accession>
    <name>A0A2T4BXS3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1310598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXS3"/>
    <dbReference type="OrthoDB" id="10541095at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="75" mass="8867" checksum="F359C09576A96E06" modified="2018-07-18" version="1" fragment="single">LSYTSNSVTQIKKKTYSLLFSPLRPVSAQRISNISFAKSVAQRWQDPKKRLIPWRLLRIYHHVESRSKVGKEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXV9</accession>
    <name>A0A2T4BXV9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1380812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXV9"/>
    <dbReference type="STRING" id="983965.A0A2T4BXV9"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="278"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="696" mass="79210" checksum="C18669E54F5E313F" modified="2018-07-18" version="1">MSTQTLAFNRASKPISVQEFRDAVLSVCRPRFPTAYYARPQRVALAISGGVDSMAMAYLFSRLVRMYRGIKIADYPTDTAFGVVVDHKLREESTQEASRVAQELKRLGLKALIKTLNWRELKWHGIEPTTMPNLESVARTMRYQALGAACTYLQSQSLFFAHHQDDQYETVLMRLLAGHGYRGLQGIREANAIPECYELHGVYKSGLLDDQMQKRPFLSFKPAGREMRRLRNILRDDKEAEPWDQIKSYLSSNDRSMSFPGHLSREFDPKVPYLTPLQSEDGGVTIYRPLLEFDKARLIATCEANGVQWFEDSTNTDPTLTTRNAIRQLTRKHTLPKALQKPSILALAQRSKRRVRLEEAEAHRLLARASTIKDFDPNAGTLRIDVSTLWRASPQQMRRPFFQAREEARRRSRRLLAAIALRKLIAFVTPELHLPPLTNLENAVGRLFPELSGETDVAPAAQPKAFSIAGVLFEPVPNLNSTSWLLSRAPYSSRQPLPERKLPGYLNYRAGIFKMDGEGDQPSRHRHWRGWKTAKLWDGRFWIRVSACVAAKFQVFPFLPSSAKPFRMALPPRERANLEKILKHYAPGKVRYTLPGLYSVEEAALDRQDAEPILTLLALPTLGIHIPGLERWVRYEARYKNIDVTLLASGKKKSSKMSLLGHAHPPVRKQSIMQAKRLRTSQTRQAPGTWKAPACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY30</accession>
    <name>A0A2T4BY30_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_21036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY30"/>
    <dbReference type="STRING" id="983965.A0A2T4BY30"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="313" mass="33549" checksum="3694BE9F3CCEA246" modified="2018-07-18" version="1">MATTFSLEEKRFVLAEMIKCSTVDIERLARFVESNVLDPKWITMQIPSGRNLEQCMQVADSLSSAPGYRSAMSQSDHLTGNGMNHARQMAPRMSPGGQAPGAMPTSPGLMSPWQHPDGAEDRRVLPQETPGEHTPKKRGRPPRVDRKTAAPPRLANIAPKPPPLSPGPNTPRTILPATSRQADTQNPQPQPAVRALPPLDSPPAKKKRRTATGAASVSASPPLPPVSAPVPAPAPTPAPAPARAPTPYLPLVTTPPPSVDYGNRTRAPPETESKIVRETEQMQPPRPMPLEPEPRHHTLMPVGSAAPPSQIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY33</accession>
    <name>A0A2T4BY33_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1299010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY33"/>
    <dbReference type="STRING" id="983965.A0A2T4BY33"/>
    <dbReference type="OrthoDB" id="5424797at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="225" mass="25249" checksum="1C9409274789EE83" modified="2018-07-18" version="1" fragment="single">SPAPQPSSGRGRPKGWKPGMSYSALRGPPAAARPGRPAKPKPIAPLAGHAKRRGRPPKAPSPLPWQVYRSLQTPFVAFLCEWTGCRAELHNLDTLRRHIFVVHCRKAPFTCRWAACAQKPASECEFRDEASLQEHVEEAHLVPFSWHVGDGPRNSGRPVKPPLEDDEIPKFLQDEQGNQVTPSVRDQPVEDFATFKQNRQKLKDLLFRMNENLPSEESDSPVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYH1</accession>
    <name>A0A2T4BYH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1424162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BYH1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002040">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="893"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1117"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="195"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="599"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="893"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1472" mass="163289" checksum="9734A2F81494EF70" modified="2018-07-18" version="1">MADPGAEKETQASIAAPGTGAISIETASEGRNDEFDSEKAVHASEKDGDGIERVDSRSDQEEDSPKEALRATKSHATDASAATTAAVVQQPKLRWYKRLNPMRWGGIPEIPKERIVSREYQAGFFSKLTFYWMNPLMTTGYKRPLDKQDIWLVNPDRAAEPMTVRVREAFQRRVKNGQKRPLLGALHESFTFEFWLGGVCSLIATVMQVLSPFVLRYLIQFATDAYVARVSDSPAPHIGRGLGLAIGVTLMQIVQSVCISHFIYRGMMMGGQSRAVLIGMIYEKSMVLSGRAKAGGVKEAATPEANEQEENDKSKGKGKGKDKKKEGKGAPGHDGSGWSNGRITNLMSVDTYRVDQASALLHMTWTSPVACIITLVLLLINLTYSALAGFGLLLIGVPLITKAIQSLLRRRKAINKITDQRVSLTQEILQSVRFVKYFGWEKAFIDRLAEIRSKEIYSIQVLLAIRNAINAVSMSMPIFASMLAFITYSLTNHGLAPAEIFSSLALFNGLRIPLNLLPLVLGQVIDAWSSLQRIEQFLLEEEQEEDVVFDPEAEHAIELKHASFTWERSPTKEADKADAGKTKKSAKKPAAPKEAAPSASGDDSASTLVEEREPFKLQDLNLQAGRNELIAVIGTVGSGKSSLLAALAGDMRKTSGEVIFGANRAFCPQYAWIQNTSLQNNIIFGKDMDQDWYKEVIRACALQPDLDMLPNGDLTEIGERGITISGGQKQRLNIARAIYFNADIVLMDDPLSAVDAHVGRHIFDNAILGLLKDKCRILATHQLWVLSRCDRIVWMDGGKIQAVDTFENLMRDHKGFQELMETTAVEKKEEDEEEDDDKLKQLTLSETAEARKNKKNKKGAALMQQEEKANSSVPWSVYGAYVRASGTLLNAPLVIFILILSQGANIMTSLWLSYWTSDKFGLSTGQYIGIYAGLGALQAILMFLFSVMLSILGTTSSKVMLREAMFRVLRAPMSFFDTTPLGRITNRFSRDVDVMDNNLTDAIRMYFFTICMCTAVFALIIAYFHYFAIALVPLYFLFIGAASYYRASAREVKRFESVLRSNVFAKFGEGLSGVASIRAYGLKSRFIKDLRDAIDEMDGAYFLTYSNQRWLSLRLDLIGNLLVFTVGILVVTSRFSVNPSIGGLVLSYILSIVQMLQFSIRQLAEVENGMNAVERLRYYGSELEEEAPLHTVDVRPTWPEKGEIIFDNVEMRYRENLPLVLKGLSIHIRGGERIGIVGRTGAGKSSIMSTLFRLVEISGGSITIDGINIATIGLFDLRSRLAIIPQDPTLFQGTVRSNLDPFNEHTDLELWSALRQADLVPADAALEDRKTDPSRIDLDSVVEEDGLNFSLGQRQLMALARALVRGSRIIVCDEATSSVDMETDDKIQRTMATGFKGKTLLCIAHRLRTIIGYDRICVMDAGRIAELDTPLELWKKEDGIFRGMCDRSGIRVEDIESAKLELDQLTAAAGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYP9</accession>
    <name>A0A2T4BYP9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">M440DRAFT_1393498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYP9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYP9"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="368"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="474" mass="50526" checksum="EEFE26AE602E5FEF" modified="2018-07-18" version="1">MDASSAQVKVVFTTDEPDLVLPESKRQLLVPADIKRYGLSRILNSESMLDTSSPVPLDFLANGTFLKTSIEEYLKSNGLSQETTLTLHYVRSLLPPVYEASFEHDDWVSGVDVLSSTSPAGLLAGDATVNDRVASSSYDGLVRIWNPSGTAIAVSSGGKGEGHTQRINAVRWLSPTQLASAGLDRKVVVWDYKEADDGFSGTLKPNMELWGHEKNIHNIDVNGATRRILTASSDGRVGLWSASKRTAPQADPESLPSAHSTKRAKLSNAGSTAQRGPLAMMPLHDEAVTAAIFHPKDSTVAYSASLDHTVKTIDLTTQREVSRLTTMHPILCAAALPGTSLVAAGSSARHITLLDPRESAAATAAMTLRGHVNMVVSVAPSPENDYSLVSGSHDSTCRVWDLRSVRPASSDEGGGSVSEPVYTIGREWLKGKKLPPAGDGAKVLSVAWDKTWGIVSGGEDKKVQINRGKGLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYT4</accession>
    <name>A0A2T4BYT4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1464421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYT4"/>
    <dbReference type="STRING" id="983965.A0A2T4BYT4"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02867">
        <property type="entry name" value="PseudoU_synth_TruB_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="493" mass="54821" checksum="18A2ED23468CE0FD" modified="2018-07-18" version="1">MASDVVRDGVFAINKPCGLSSAQVVRECQQAFNPSALFKPMIEAEIARRLKESGGQFMRRKAEKKASQVKIGHGGTLDPLATGVLILGVGSATKLLPQFLDCTKTYETIVLFGASTDTYDRVGRILSKRPYDHITREMVEKELEGFKGKQIQIPPLYSALKMNGKPLYEYAREGKPIPREIEGREVEVLEVELLEWYEPKTHNHRWPTEEAEAAERNLAEQVWRVKKQQETGRKLTPEEKEQDDQAVAAHETFKRRFEERQDELIKDAPRKKQRPSKHSAMMSGALGQLPQPVYSSKGKNLVPPTPDESTPPPWSDEGPPAARIRLKVTSGFYVRSFCHDLGAKLGSAGLMAELARVRQSDFTIGGTNCLEYDDLAKGEEVWGPKVADMLARWNGEPEGSWPGLKAASKPTNQPTEKAEGQKRQERKSASPVASPTAATRSEKRSRSPSADRTASPARKIQAKGDGEKPSRQTNGTKTPTKSDDEKSWNGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ26</accession>
    <name>A0A2T4BZ26_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1403059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ26"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ26"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000033">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="40125" checksum="3ACDDB000EC9CC70" modified="2018-07-18" version="1">MAPLAQAVTVSLKDLQNGNVSFETLQQAFGPDSLGILVVKDVPQEFAKLRHLALSYGSYLGNLPKEELDKLENAKAKYLTGWSLGKETLKNGQADTFKGSFYANCAFYVNPSLECAEPTAEFSPETFPEYLSPNIWPAENVLPGMKPAVTSLCRLIIDVAVLVARACDRFAEKEIQGYPKGYLEHVVSTSNTTKARLLHYFPQGASEAASTAAEGDEDDWCGTHLDHGCLTGLTSAMFIDEQRVNPTVPTADLTSLNGASLPPLEELPASPDPAAGLYIKSRTGETVQVKIPRDCIAFQTGEALERITAGKFKAVPHFVRGVRASVSDGRIARNTLAVFTQPNLDEEVDIEQHLTFGEFARGVVTKNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZK8</accession>
    <name>A0A2T4BZK8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_56182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZK8"/>
    <dbReference type="STRING" id="983965.A0A2T4BZK8"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="45"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="147"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="313" mass="34570" checksum="1FF2A4D1FC7B7024" modified="2018-07-18" version="1">MMRGFQDGNMAGMTIGLTAVLNFARDEAWKNRIAGEVFSGKKKLCLAITEAFAGSDVAGLRTTAEKTPDGKHYIVNGTKKWITNGVFCDYFVVGVRTGKALSVLLIERGPGVETKPIKTSYSPAAGTAYITFDNVKVPVENLLGEENKGIHVILSNFNHERWVMSCGSIAASRFIVEECLKWSNQRIVFGKRLIDQPVIRQKLAKLIALVEANQSWLETITYQMCHMPYKQQALHLAGPIGLLKMSITRVAHEVADEAVQIWGGRGLTQSGMGKYIEHFNRTYKFDAILGGAEEVLGDLGVRQAMKNFPKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0C4</accession>
    <name>A0A2T4C0C4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide lyase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1423913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0C4"/>
    <dbReference type="OrthoDB" id="3889489at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015641262" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="258" mass="29181" checksum="A6D8A8A61608DC08" modified="2018-07-18" version="1">MGVIKSLMVVLASLQAGLATQTFQNGGTTAGFDYVLTENQGKVLQVSDITYKGNTALLMQQTFTPGYTGRYHSEVYHNQGYKRGDELFYGFMFRLSSSWEFDQQSYNIAQFIADRPGAGCDDDDWMPSSLIWLEGNQLNSRIVSGNYRQPDCSRSFTGTGNIATVSAGVWHKVIIQAKWASDTSGYYKMWFDGNKVYEHYNIATTTNDDYVFAFRVGLYANGWHDDKHMVGNQSFRQIWYDEVAVGTTFADVDPDQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0N9</accession>
    <name>A0A2T4C0N9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_24934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0N9"/>
    <dbReference type="STRING" id="983965.A0A2T4C0N9"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="13424" checksum="5792E5E209839334" modified="2018-07-18" version="1" fragment="single">PSKLNIKLLSRPSSTFSSRPSPPKLPAAQQAEFERLQRAAAVSSAFQEAQQSSPPATEALRHTSSPTAAKDKGDGTTLGQGLFRGAKPEFEGDVNPKTGEVGGPKNEPLRWGGEGDWSYNGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0T2</accession>
    <name>A0A2T4C0T2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_338417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0T2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8304" checksum="36162361AD6AC901" modified="2018-07-18" version="1">MQALKLTMQAATPMTPSTATGCSSVRPGRWFGPPQGHSGSSTGTSPFPAETSVPHPAGSRYLHRLPLSPWHLILGHWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0U6</accession>
    <name>A0A2T4C0U6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1439702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0U6"/>
    <dbReference type="STRING" id="983965.A0A2T4C0U6"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="33190" checksum="52B8D8315E442856" modified="2018-07-18" version="1">MAPTGISKKIWFVTGASSGLGLNVALSALRAGHRVIGTGRNIQKASSAHPEFAQLGGEWLQLDVAQPKAEQTIRQLVAKEEHKLGRDKDSAHWVVVNNAGNTLLGAVEDMSEGQIQEYLQTNLFGFVRVWKALLPTLRRNRTGTLISISSIWGFVPKPEHMLYSAAKATTESLTESYASLLEPFGIRTMIVEPGGFRTPFAGNNSLADGGISEDYKPVIQPWVDLVNAASKDLTMVNGDPVKFGDRLVDAVDDQGLFESIWAAHDGTKALRVQLGSDSYGLFEQRLSDFEEGFAKMAEVARSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Y9</accession>
    <name>A0A2T4C0Y9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1336332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Y9"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Y9"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000149">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="35718" checksum="884D9B89650C3425" modified="2018-07-18" version="1">MHFAYPSRKSSNPPPFRPRSTRLPGLRRSRIKTIGIVLFLVLATLWFFSNPRVPRPDPERVPSGRPPVVLVTVIDPTQYPNAYLKTIKENREQYAAKHGYEAFIVKAYDYDTQGAPQSWSKLMAMRHALTKFPECRFVWYLDQDAYIMDMSKSLEEQLLNRQRLESLMIKNYPVVPPDSIIKTFSHLRPDEVDLIVSQDSSGLVAGSIVVRNSQWSKFLLETWMDPLYRSYNFQKAERHALEHIVQWHPTILSKLALVPQRTLGPYTRTDQGDAYQDGDFVVMFTGCTKSGDQSCETVSASYYQKWSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Z0</accession>
    <name>A0A2T4C0Z0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1336114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Z0"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Z0"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="655" mass="72958" checksum="485BA420E5550918" modified="2018-07-18" version="1">MQNLSLPVRTSASRRNQESRSYFTSYTPPSSTEAINGPVREPVREQPPMTDRLIVGVDFGTTFSGVAAVYTSTPDDVEIIKTWPGGNGITSDKVPTEIAYSFPPDAAPGTEPTVKWGFQFKPDESRLRCIKLFLDRAQKLPFYVSPLDTAAQLKKFNKNVMDAVSDYLTQIYRHTMDTLTRRYGESFMASTKVEFVLTCPAVWSDAAKNTTLQAAERAGMGSRSEIQMISEPEAAAVYTLKAIQPNHLNIGDNFIVCDAGGGTVDLIAYKIISLKPLRVEESAVGTGGLCGSAFLNYRFEEHVRTRLGQARFDEMKTKKGKTWQMGLRYFEEFVKRNFDEDEHQEINVPFPGLPDDEEAGLDSGFMVMSAEQIKDIFEPVVKEVCDLVQGQVQGLRAKGGIVSGIVLVGGFGQSDYLYRRLKAHFSSPAPPPYSERPTHATAGTSQDVGSIEVMQPVYAWTAVVRGAVLRGLEGNMVISRKSRMHYGTSFATVYDEEKHSVSERYWSPLWERWMVSDRMQWHIAKVGALIHPLLMSFDSFLCASWGESLSPLSPIAFHYTRNFRPGQSLIVTDDLIACDADEPPAAYTRDLINVCTLTTDLNAVPRSLFTRLTTTRGVEFDNLDFTLEMIVDSAGLGFELKVDGVRYGRVEAEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1C7</accession>
    <name>A0A2T4C1C7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1272774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1C7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="111" mass="12405" checksum="AC7C26ACB31687AC" modified="2018-07-18" version="1">MLASSHRKWHCHRNREMCLAKGDGRFAHQVVTVAAQHTSSDVHPRFIRAELGVCMASLVILRALIELAKDLRKISKQEKNVYSSIASISHGGSNTCKPDSFLPLGRNHIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1V2</accession>
    <name>A0A2T4C1V2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF814-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1334900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1V2"/>
    <dbReference type="STRING" id="983965.A0A2T4C1V2"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="203" mass="23918" checksum="C97E07E7278B419C" modified="2018-07-18" version="1">MVYYFTSSVVEPAGFIYVGKDKFENEDLIKYGWEEDFHVDKLSSAHIYLRMQPGQSWDNLPEQLVMDLAQLTKANSIEGNKKDNVTIIYTPWSNLKKDGSMDVGQVKRVLVPHRENAIVNRLNKTKVEKKPDLKAERDDMLKELRKKEQAAQLIKKKEEQRQAQEWKEKKWQKDHAYDDLFTDENMAAASNQDRTEDWEDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1W2</accession>
    <name>A0A2T4C1W2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1257018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1W2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="95" mass="10720" checksum="4A5BA700BD4654EA" modified="2018-07-18" version="1">MARDWLLVRLRPASPHLLLSRSRCWSSVRVSVTLAGRTSCADVSKRAARMNARVVVRGRARNWVRVTRGGCARVDDLIRCLALVVCKVSARRFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2B1</accession>
    <name>A0A2T4C2B1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2B1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="85" mass="9428" checksum="C79DF0C88B55D28B" modified="2018-07-18" version="1">MVFLSAKTSYSQPIQTNSIPRTTRKGSQTNTHVDTCTPGSHTDSCIPHAHAAPHTNYSSSQPFTLLPPPIMQLREKRERKKIPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2B2</accession>
    <name>A0A2T4C2B2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1258394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2B2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="87" mass="9997" checksum="937FA9AC17ABD5BB" modified="2018-07-18" version="1">MRARKDGEPVCALISIRGNWSVLLFVSVENAHHGADRNRGDVDGRIVSEVIHADWRRRAQYNHYHAANRILYAGYGFVFLFPLRSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2D2</accession>
    <name>A0A2T4C2D2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein translocation complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1357194</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2D2"/>
    <dbReference type="STRING" id="983965.A0A2T4C2D2"/>
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</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2E1</accession>
    <name>A0A2T4C2E1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1402263</name>
    </gene>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="PTB75736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8471" checksum="1274F538A7107951" modified="2018-07-18" version="1">MANGTREAAPGCWDFRAAGGWWEVGGWEERERFWCAEKGDGQRRLSLVFSFGWLAAAGDVMGLVCDSRREDSPTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2M8</accession>
    <name>A0A2T4C2M8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1357251</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="103"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="335"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB75758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114009" checksum="5B1C8B0465691FC5" modified="2018-07-18" version="1">MESQIENAVEILSNPASDQSVKEQAFEYLNHLRTNPSGWQACTNLFARIPRTSEVVRMVCLEVVNFAVHTQGLDADSLAFLKQTLLQYVRQAYGPGAQQEPDPAHLQNKLTQTLTYLFVFLYRDGWQSFLDDFLDLTGLPQNVDNVPGVLFYLRVLSSVHDEIADMLLSRQTSDSKRNTELKDQLRAQDMQKVAESWKQLLSRYSGNDAVIDLVLKVIGKWVSWMDISLVVSQDMLNLLLPVVGRTGSEDKVRDTAIDTLTEICGKKMRSADKMDMISFLSLQDIVSQLVASPMLNDLKGTPQYDTDLAEAIAKLVNTTVSDIVRALDDNQASEETRTRAKQHLDGFLPLLLRFFSDEYDEVCSTVIPSLTDLLTFLRKLGQLSPEYSGMLSPILNAIIRKMRYDETTSWGNEDEQTDEAEFQELRRRLQYLQKTIAAIDQSLYMDVLSNLVATTFQTLDQAGSQMDWRDLDLALHEMYLFGELALPNQGLGTKNQPSSEASERLVVMMQKMVESGIANFSHPAILLQYMEICVRYCAVFESHSQYIPQVLENFVRLVHHNHVRIKTRSWYLFHRFIKHLRSRVGNVAETVIQSIGDLLPIKAEVPGEDADDDMSSDESDHSADALFTSQLYLFEAIGCISSTHSTPADKQALYARSVMDPLFRDMEVHLPRAKAGDAQAALQIHHIVLALGTLAHGFSDWTPGTAATNQHGPPDKLVSDEFSRAAEAILIALSELNSSAEIRTACRSAFSKLLGVLGAAVLPQLPKWIEGLLSQSSSKDEMAMFLRLLDQVVFGFKSEIYEVLNMLLTPLLQRIFGGLGEPISGTDDEIQLAELRREYLSFIQIILNNGLEGVLVSEANQGFFEPMIASVLELAKTLDGNLGPSRLAFTIMGRISSLWGGPDVATISKTPTAPTGSPSPVIPGFDHFMMERFHTACWEVMRNPNFKPSSDAQTKQVLTEIAALEQTIYTKTGDMFIQQMQNEVFPSLGINGDDFLRSLTTSADKRQFSTYLQQLLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3D3</accession>
    <name>A0A2T4C3D3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1438842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3D3"/>
    <dbReference type="STRING" id="983965.A0A2T4C3D3"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="698" mass="77089" checksum="7091CC4C5D939BF3" modified="2018-07-18" version="1">MDAPRLPSSRFMEFTRQLSHDSSVDTPPDFCDSMDANHRFPRAIDPADGHLPHDDLCLDAQASVYSAESLKPLKMPPYTFKASPPSTYAMASLMGYAVQPQSQARHGNSTPAESPSVPETHFSFSWDTYFNDTLAETSHPVRLGKDALPQTEKHCDDDCRSMLSCTSACGISCPSQCGDTGQGMCCDDDACDDQELCLDEMCEDAVTPCTDANCSGLAKLGQLPAEPGFSDGDKQAAAALASIGDTQLELMHSTFPQFTPDSTFGSHPCFPGGTCSHAFPHTSFQTTTDDGLAGQFWEHLSQEDPLTTHILQYHDPRHFVDHARPCIADDPNLTIPKCALPKTVNGDLLSHGLGHNPHDFACGFEVNTLDQFASHIFEDHWYMHMPHSDLGNPSQHSHLEDNFSLIPSRQNLPQPYFSNVPSTNDLQLTASDSSLQSPPVAPPLSPPPTSQTTSPPAQAEESLTESQAESQAESMPSELTPISPPDLETAVEHTCLWKSSDGKVCHMQFKDADDLHNHTKNDHLKDMTRQHPGFCCQWENCTRATVFGQKSKLERHIQTHTGYKPVKCSICGLQLSAKQSLDQHMRVHTGEKPWKCKFPGCSHAFKQQSALTMHERTHTGYKPLRCDICGKSFGESSNLSKHRRTHNERGEHSCPICNKDFNRLDQLRRHLYSNHKCKPDEAESIAKANKAKLGKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3I5</accession>
    <name>A0A2T4C3I5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3I5"/>
    <dbReference type="STRING" id="983965.A0A2T4C3I5"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="716" mass="75444" checksum="B75E33AB3AE477D0" modified="2018-07-18" version="1">MAEQQPSTAASAPAPAPASASATGPVGQQQQPAAITTAVPFKSAPPPPPPPPSASPAPPPPPPNNAAMTGGTPPVPGHGMQAPSPTNGVPGQSPLVRSASEAASVGSGVMGGAPERGGSAPVAQGGEVKAGGNDEKARAYRALLDLVQKTDASVVRQVVREHWGKCLTGSEYHSSFVTNAAINYSPPGVISRTMADLGEKVVKASKREIAKHFSGQDLDEIADLIGPKLSSHFQDRVMATRLETIGAQDLINALARAERLGYHINDIVKKKPGPGGESVIPGINTLITSLPPQMPPHQMHGAPPPPMPPHPGQGPPQQPHPAYPPHPSQHYGVPQGQHPVPMATNGAAVHHGQPAPSQPPPPVSTPRQTAKAAGRIVYCGTCHRPCSSQEALSYHHKRAKCHTLKQGENTNADTCVHCGSLFESSGGLAYHLKSDVCGAHSEATRLQMIELVKQWEHMRKQAPSQPPNTYIAPSYQTTPSRPADAATPAARAYTTPSQNVSTPVATPSPSSNDPYAKLTPDQRRAFDLEMKQVDDYYLGQMRDAQARLPAGPREEEIAKLKNRYNTKQSMTRKKYGIRLRGRRADTEVDRSESAGTGDPAAKKVRTDDGQARPTQAASQVAESPRRRVPLAEMGGLSASSATAELVDPTTSSANSQPPPPTATPAQSQPTTRPPPSFQVAIPAPTHNGTHDDPMQIDDDNSTDSDNMDIPARIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4D6</accession>
    <name>A0A2T4C4D6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1252005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4D6"/>
    <dbReference type="OrthoDB" id="4895274at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="436" mass="47394" checksum="D012CA3BE3548712" modified="2018-07-18" version="1">MVLLGSLPRSRSLESLRKDLFHTITHTTEGVYFPPGCTLLDSKEADKEVIAALCPNEEFKAPDKGVAHLTKLFVQCNKWLPVLEKCDTKKYWAVVAFTTSKLQGITMSPKMAKGLAMSLLKARQLWILRQENPDAARSNVKTHLAAGIQRLLECFEQRAKQPATQARGDNQEWQLTDKQIEDACKARMGPGKRVSKNRIALSFKSPHPLVPIGQLSSTPQLEHSPLNSLGMLHSSVEKITPAEAVQALLSNQMQDLLRDEFTVEQQAAAKRASHSASLAKVAHDDDAQSGSSKASSLMKGMTPSALKTKFKSSWMKSPVYCKDTGKTSAEAAKRAQTVDASPTPKGTGKSKTETTKRAQTAEDSPTAKAKTNIQPSSTKKRFMNELPGNAAKKQVVAKGTARSVSMPVHNGSSVAPAQQTQVARSVSLKVKKGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5H5</accession>
    <name>A0A2T4C5H5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Longevity assurance proteins LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1331951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5H5"/>
    <dbReference type="STRING" id="983965.A0A2T4C5H5"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="156"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="474" mass="54104" checksum="E656082013D285D7" modified="2018-07-18" version="1">MGDSHGLVGEKTATGSSMAPQSSRSTNGAPNGSLYLQASGSNGNVVLVRRLRRRDEGLWKPLARWFVENQVGLSLNLLALLFLSHACIPKAREYTTKFFHLSYYNDTTGKYATGFDDAYLIAFFIVLFTGLRAGTIDYILAPLGRLNGISRRKDVTRFSEQAWLLVYYAVFWPTGVYLYYNSPAYLNMRELWTDWPNREMGGLMKWYMLAQWAFWLQQIVVINIEDRRKDHWQMFSHHLITTALISSCYCYHHTRVGMFILVIMDVVDLFLPLAKCLKYCGFSTLCDVTFGLFMVTWFIARHVLYMIVCWSIYAHTPEIMPNGCFVGPNSSLQGPFDAPAGFTYLIEPFFNSTGRVCFNETVKWAFLTPLLLLQGITIFWFCLIVRVAIKVIRGDGAEDTRSDDEGEEVDDEEELIYEEVQPLEQEVGVEELDLKSWERRNGLKKQASASGVSLPGHSDRKELLGRIGCEKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5L7</accession>
    <name>A0A2T4C5L7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EPT/RTPC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1332830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5L7"/>
    <dbReference type="STRING" id="983965.A0A2T4C5L7"/>
    <dbReference type="OrthoDB" id="25029at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="416" mass="45471" checksum="3594D845A9E388A9" modified="2018-07-18" version="1">MPKTKPIVLDGRTGEGGGQLVRLGIALAALTSQPVEITNVRGNRPRGGGLKNQHVAAIEWLARVTDADVQGLSVGSKSVTFTPRRPPSELFQRNISIRTESGASSTLLVLQAMLPYLFFASTEANDEPVVVELSGGTNVSFSPSYEYFDQVLAPTLEERFGVRIERALKSRGWSLGPLSRGSIALKVWPVARGEKLRFMPPPRYTFPESFEVKRVDVSIIAPMHSHNKLQETIIQDIGALWPSADISFKVIEDSCSDARWSVLLVAHSADGIRWARDVLTSAPKKAKGYDRFVALLSKKLCRELYDEVSLGGHVDEHLQDQLVCFQALCEGHSSFPRDDKGVNEAVDGGGALGSLIDAMSELHVGEGRMRREKMGEPFGHGSTHTKTARWVVGEMVPGCEFYNKGDVVKGVGFSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5N1</accession>
    <name>A0A2T4C5N1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1237291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5N1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="191" mass="20315" checksum="852EF0FB486868B8" modified="2018-07-18" version="1">MAILDPPQGQPAVGAKGTVCSPSCIHLSCLLFVFTCILLTSSNLFPASLPSQSGLICPCRQYTHADENEYKTGCYVLQVRWRRGLPRFSAITAAGLPHEDPPRTTIHGPGEGDGHLKISGGGLARGSEATRATTQSRPSGRRRFKFLGAGRRLVRASPGAGSILLILLILLLLLLPLLLLSLLSFSSSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C630</accession>
    <name>A0A2T4C630_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1332033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C630"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57477" checksum="4A4E0F2F2A492D74" modified="2018-07-18" version="1">MSTNPASGSTSTGETNAGTAAATSADAPTKRRPGRPRMKDSLPADSNDNSRRSRMRLAQRSYRSRKENELATTRARADALQRALNSSLDEFIRFHELSSGKEKDLPSDFVLQLNRTAMNIMAIARSAQADHWPALDHADRLLAATAGEKNKSTAGEDDGSSTYILRDGLPAASSSWGNASSSSSSSYAPPERHNPLRPKPVTISQRLMRACVDRAASMLHLTSSPVMCLLPAMLLPLQHDRRDNLLSRTMRYLSITHDDAAALTLDAEHSLQATRRLPRMLRTVEGQGSSSSSSSSSSTTMVPRAPPPNLQRLQFGRTRTVLATALPDLQGEWLEASDVEEYLEQRGIFIRQDAPDADTLNLAIPVDAGLALQATDLNDANRLNPVRMVRGHPLFVEPAASVGPQQQQPSLDNIALNPDYTIFGQQRDVQVIPSGLRMFTPTAWSIDDSANIIPIDMAMRSNQPNNASGGSSSSYHSSNNPDHINIMVNLDNLIVKLASKAVCLGPCPGIRRGHVDEAIRDSVVQMPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C673</accession>
    <name>A0A2T4C673_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1438741</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C673"/>
    <dbReference type="STRING" id="983965.A0A2T4C673"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB77069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="233" mass="25737" checksum="5D55B7BE96F21A54" modified="2018-07-18" version="1">MASSSSATPLLYSCIAHKTTILSECTTSASSQTSSLASLILPKIEHATPQKLTYTHGQHQIHYVAEAPSDHPDHPAAGGLTFLVIADASLGRRVPFGYLLEIRKRFFEKFPEHTDFADMPNYGAASFNAEMRSLMVEFGTTSGGMNDAIGNAKREIDDVRGIMTKNIESLLERGERIDLLVDKTDRLGSSARDFRVRSRGLKRQMWWKNVKLMALLTLVVALIIMIIVISVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6H5</accession>
    <name>A0A2T4C6H5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1330972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6H5"/>
    <dbReference type="STRING" id="983965.A0A2T4C6H5"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="169"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="340"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="440" mass="45731" checksum="C66B9D9C5BF314B6" modified="2018-07-18" version="1">MTGTGAAPAGGPAGGYGGQPPQRSYEERAAAREQMMSNIRETSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVLFADVLLLPNGMSKGCGIVEYATREQAQQAVAQLSNQNLMGRLVYVREDREAEPRFIGATGTSARGGYGGGGMHGGFNPGYAGGPPGGGGGGGGGRQIYVANLPYNVGWQDLKDLFRQAARIGGVLRADVHTGPDGRPKGSGIVVFESPDDARSAIQQFNGYDWQGRLLEVREDRFAGGGGPMGFGGRGGFGGGMRGGFGGGGFGRGGFGGGRGGFGGFGGRGGFGGGVGPGPGAGGPGGGFDASTAPAVLPNPFTDNATAGTERSEIIYVRNLPWSTSNDDLVELFTTIGKVEQAEIQYEPSGRSRGTGVVRFDSPETAETAIAKFQGYQYGGRPLNLSFVKYLNQPGGDSMETDAHAGLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6K5</accession>
    <name>A0A2T4C6K5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_274257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6K5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="111" mass="12729" checksum="EE4C461350D5C0B5" modified="2018-07-18" version="1">MAARSRSTRQRLHLAFAQVGRERLADRQRRGTTKQKQRPNRDKDSLARRRREKGQTKRQVGKPVEKKVRQARPPPSHKILSPQVSLPVLFVCVCVSLSSFTVLRPQPVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C745</accession>
    <name>A0A2T4C745_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1400316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C745"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="90" mass="9776" checksum="2631A33E9A6ADB1F" modified="2018-07-18" version="1">MQSHFGPSQSHPVQARSVLHRACSLTPLLLGCKGGGLFACLATASIISELRAAVFWLQSDCTSNTTYSTIHRDRGIVHQVGQQCLDKRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C988</accession>
    <name>A0A2T4C988_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1185377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C988"/>
    <dbReference type="STRING" id="983965.A0A2T4C988"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="285" mass="30679" checksum="9418DBCF98BBCFCD" modified="2018-07-18" version="1">MPPRKSDVRPSTPVAAEEASPSSAKAAQTLDKTDKKDKDKDKDKDKGKAEDAVTIEDLTLPKSIITRLAKGILPPNTQIQGNAILALSKSATVFISYLASHANENTVAAGKKTILPADVFKALDDTEFSFLKGPLEAEFAKFNAIQTEKRTTYRQKVRASKHGPGGGGDDTDMADTTMASEASASSAGPRAKKARVAHEDNEDEDVDDDEEIDAIVNDDDDVVDDDDDDEDEEEEAQEDDEDAADEDEDEAGDGAEGSSDETQDALEEKRSRDEPDEALEGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA17</accession>
    <name>A0A2T4CA17_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1429384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CA17"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="743"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1180"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1661"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1661"/>
            <end position="1672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1736" mass="196358" checksum="3534584D48410B19" modified="2018-07-18" version="1">MTSEKANKEDLPSWYANLWAPRVDLIGDIAGKEPFLIHGESLIRHCLEESPPDFQEGFQLLHAVYVVERFLSNLQKRGCDFDVVFFRNLRDLCVPRHSGSEYKYQFARTVIIKHLQRHAEERARNGARASVLEFESVDSQEFDQYLEGLPIHFVLCHDGLEVEGVKDTIILRNLIRSLLWRGKNVAIINHLEWKSSKAYAPLLSKLPEKMRPVPIAKKFDSPYTSILDGMNLRLQPMLVEPQDLTARERLGIAACLTLANSPGNVSTDQGHMQEGVQAFLLHLAVLKHCTLLERQHWVGSPRSISTLEDRDFLRKIIEVSLLLMGKDECTTSINTAECTWDLFDAIDGSLFHFTMDSLRSGQWFPDQITLSWKHLWSVFRAATDRKLPEGLPELAKVPTETTISDDFDKPHISALPFSHPVLDPFLKDIKLKEGQEIRDVSLHSVFEDLHHWHNTKLLLPPLKTQKLGFFARKRIQKRVADIVAYSASLTNARGKLIEPETVVVKKAAAKQASNNNKSTTESSSSNSTATQSQHQSKKSGRLANKPGGRESALKAAQEVQERKASVKRDNTVTLWANTCREIEKEHSLLVRYLKALRFLNDRPKPDHAVLGSEVHLYLCHLLGKLWAEAWTGTNTKAGTYLIALIWRWLQELPMIGVSKAVAQAVHKLTACLEIPDLPVAVGNQPHRMSFQFDYGALKDIKKVMSDFRQMQLEFAAPYMDRRFDSKPDKRVPFEPDAWQIKVLNSIDANNSLLVIAPTSAGKTFISFYAMKKVLEESDEGVLVYVAPTKALVNQIAAEIGARFTKSYKQDGKSVWAIYTRDYRVQNPTGCQVLVTVPHILQILLLAPTNAKGPNAWSKRIKRIIFDEVHCIGQDDDGVIWEQLLLSAPCPVIALSATIGNPGAFQEWLSQVQRSKGLKLDTVVHTTRYSDLRKFMYMPHAREPFRGLRRNKALPVPGLDEGDRACPEFEFVHPVAALTDRARTALEDVSLEARDCLSLWETMKQVLSKEDAARFGVPDPSSALPDIVTKADVIRWESDLKKALLRIMEGPNKVFQEIRKRLEMRSVEGASDSPPIHDKSRIFHLIVDLHSHDALPALVFHYDTHGCEQIVNTIFNNLVEAENKWKCSSPEWAQKMEDFEAWKKTARIQQTLVIRQRQRGKNKDDVRMSKDEQLREKASVDVSPWASFDPDEPLERFSFADTTKMQTSEVEVIIQPVRGNVSPWMIDALRRGLGVHHSSLNREYRQAVEVLFRRGYLRVVVATGTLALGINMPCKTVVFQGNSVFLTAQNFRQASGRAGRRGFDLLGNIVFNQIPRKRVYDIMSARLPGLNGQFPISTTLVLRLFSLLHGSDNCEFAANMVRSLLSQTRLYLGGPESEMSIKHHVRFSIEYLRRQDLLSAAGVPVNFASIIGHLYFMENAVFAFHSLLRGGYFHRLCANLHTNPEAVLLEMMLVLSHLFCRLPVRRNKKIVEVAQTSSSVIFLPPLPKEAERLLIQHNQETLSVFKNYVKSYVSHNLTRTRDRILPFTQTVVGQDEPVHWVSADSGAAGMVRSPFIALSGKKDDFKTIHELCQTVRGDVFLEESAIPTIPVWPHDTSQEFNAYLYDFFKHGSMLVLVRDNGIRRGEVWFHLKDFSRTLSTIISSLTVLMDAGDVDAEEAYGDFEGEFDGETETTDSGLRDGSSEEAASSSPTSVDGWDSAESAPVGGHAKGKGLYRVLQAFIRLRDEFDDKFRKEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAK3</accession>
    <name>A0A2T4CAK3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1420645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAK3"/>
    <dbReference type="STRING" id="983965.A0A2T4CAK3"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="340" mass="37812" checksum="557A7611777A7304" modified="2018-07-18" version="1">MAPSANSHGRSHSLLLLQRLLNFRDAASPLTLLLDNLEQPARPVISELMTRAKLAKTKIIFLSFCTVRKPREADVFIKAAGKDLNSVSRELLAQYPSFQSASIKDKTAQRAVVFIDSLNSLSSTATQSLAVFLSSIITPVVSIVGVYHTDVPVILPKSSNEYEPHPFALLCHLATAILTLSNLRQEIERQKARNRSVVEPEWGLKEHREGILIGLAERSKSEDDAGVVISMELRRRSGRAVDEKFILMPAEAAAKSRLAKLCLLTDHAMFRKPDAERGDEAEEQPESTFNLGLTEKQRKDREGIVLPYFDAQTDIGAGEGGRILYEMGREDDFDDEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB02</accession>
    <name>A0A2T4CB02_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_268062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB02"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="16655" checksum="04AE5E97D677E52B" modified="2018-07-18" version="1">MLVSPGRGRTVGPAASPLPHPTVEAGMSMDFQFWFLFLLRRAALRQLRLAALATVFLVIALRQRGRHTVQMLVCKSGSGRVKVGYQLLASLQMQSRLSVSSCPSVSLQSARAEHLANALDSRPPPTTCIGTSSHLPAPFATPPPQPPYSAQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB30</accession>
    <name>A0A2T4CB30_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SEP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1469065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB30"/>
    <dbReference type="STRING" id="983965.A0A2T4CB30"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="414" mass="44932" checksum="0EF125A8133DD272" modified="2018-07-18" version="1">MVREDEPKDHEEMVRDFVTMSGASVELATEYLETNGWDMLAACNSYFHDEDERNDARRRQQAAEGTLEQYSGPRTLDGRPAPQEDFSSLASRKANQPKKKGIATLGSLASSSSAPHNPLDDEDDEDEDDEEGDGRGNLFAGGEKSGLAVQDPRQEGGSRKIISDILAKAKANSRQSDPSAEAGPSRPTHFRGTGVTLGGDGVESRSIPDPRGAERPSGPPVERVLHIWQDGFSIDDGELRRFDDPSNEADLQLIRSGRAPLHLMNVQHDQSVDVKLHQHDTPYKQPPKRYKPFAGTGNRLGSPVPGASSTTSSTPAPATPTATATASAPTVDESQPTLMIRIQMPDGSRLPARFNTTHTIGDVYGFVQGASVETRSRPWVLVTTFPNKEHTDKSLVLGEMPEFKKGGTAVVKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBA6</accession>
    <name>A0A2T4CBA6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1429711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBA6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBA6"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="15744" checksum="5EFC20D9877DE50B" modified="2018-07-18" version="1">MSTPTRTLGNLRKIGIKEYFRQMLYIGDTKHGTLVGQDRAGNKFYENTEELPLRTRWVDYAKHDYDAGQIEPGWHAWISYAVDKPPTEDPLIRPGTRFFEPALPKPNFTMGRGAFKTYNTTKPKINAWEPVARERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBE9</accession>
    <name>A0A2T4CBE9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1329254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBE9"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="551" mass="60876" checksum="B08C16ACDE1712F8" modified="2018-07-18" version="1">MATSKDNPDIIHLETPPTQDGRKAASNEITPVPKPIAELPLTGRDKAAQFLKQATESPVIVTPSDNARVLRKIDIHLLPIILFVYCLQSLDKTTLSYASVFGLIDDTHLEGEQFSWLGSVVYVAQLVFQPLVAYALVKLPVGKFCATMVFCWGAVLCGMTAAKGFGGLMAARLLLGAFEASVAPTFIAVVQMWYRRKEQTTRNASWYAMLGVVNMLGSLLTYGLGHIKSALRPYQIIFLFCGCITVAFSLAMYLFMPDSPMEAKFLKEDEKVIAIERLRMNQMGIASGVWKWEHVREAMLDPKTWLWFCLMLTISIPSGGISTFGPLIIQSFGFDSFTTILFNIPFGAVQMIATLGGAWASDKIHTKSVVLLFLCLPPIAGCVILLVTGRGPSDRAVLLVGYYIISVYPGISPLIYSWSGQNTGGDTKRKVTTGMLFVGASVGNIIGPQLFKPSEKPRYDRGLRSNLALFVVLAILIVAGMLWIKVLNRRQAARRRALGKAEVIRDLSMMDRKKGESEYDEEVLNMGDENVGDKAFEDVTDLQNEDFIYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBL1</accession>
    <name>A0A2T4CBL1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBL1"/>
    <dbReference type="STRING" id="983965.A0A2T4CBL1"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015703742" description="Aminoglycoside phosphotransferase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47837" checksum="9C2145538AB905C7" modified="2018-07-18" version="1">MDQNFTPSQVAAIILSWLDLELISCTTIQSLWAGYGHMCAISARPTAHCEATQWQRFSRTQEDGQGSLIYLVLKIVHPPTKDGDEGHLRKMFSYEVEQYFYDEVAPHLAGDIAVAQCLASTRRMQVQAAEHGIDHLVATLMNDLRLDFPLSGEKRAVLSSKQVYAALTWLAKFHRSSWTYLPQDLSQLLLPPLEEALRRQKDPKSGGKALWLNGGYTYLATRRQEYGLLAQDKSSEWSGAFCTSVDGRPSLAEQVADFLTPRGRPFETYIHGDVKSENLFSKESGDEVVFFDFQYAGIGLGVCDLAKLFTCSIPTHMLTSHKFIPAELKMDELEMRLLNHYWLILSDSGHARKRPAYDWDDFLRHWETALVDWCRFQASWGFWGNTEWLEARVRCIIRDDAWRAWLASQARTDGAVDGAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBX6</accession>
    <name>A0A2T4CBX6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBX6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBX6"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="5386" checksum="BB7B2A0ACB877E98" modified="2018-07-18" version="1">MSNPRLRDMASQFSSGGGMPDLGSLMSDPNIAEMARNMMGGGGGAGGAPGSGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC00</accession>
    <name>A0A2T4CC00_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1419490</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC00"/>
    <dbReference type="STRING" id="983965.A0A2T4CC00"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="174"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="203"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="368" mass="40669" checksum="7FA6773526149D45" modified="2018-07-18" version="1">MPTVIHLRADTKPFERRSPLSPQTAKALLDAGYIVRVERSTERIYKDEEFEAVGAELVPAGSWIKAPKEDIILGLKELPDDDVDLPHTYIHFQHIFKKQLGWAPSLKRFARAGGTLYDLEFLTEENGRRIAAFGYFAGYAGAAIAFISWAHQILNPGVPQPPVPLFDSAPALVAHVKAALEPAIFANEGQLPRVIVIGALGRCGKGAVDFCREVGLPEDSILKWDMQETAKGGPFKEITTSDIFINCVYLGPTPTPPFVTFESLATPERRLRVIADISCDPNSENNPIPLYSTWSSFDKPTIPTSKPVDGPELRIIAIDHLPTLIARESSDEYSGLLLPALLTLDKRDTEGVWTRAEKTYKDRVAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC03</accession>
    <name>A0A2T4CC03_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_227236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC03"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="185" mass="21336" checksum="697CBED5C98CAC54" modified="2018-07-18" version="1">MTGFFSSFSFLRFEFEIHEEQRHLDICHYSLPSRAGTRQSVVWFRPGDICGLHGGRKPGLQSVPAMLVFWLIHFGKRFKRAEMIYQCGSTWEQEKWTFYLILCVCLRVNDGELPLLLLCARPCLGEGEWPMIALQDAAMQLILVHPHPWCKALLLCWRLANVMHQVLLYTRTCTSDRSSGLCQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCI3</accession>
    <name>A0A2T4CCI3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1326488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCI3"/>
    <dbReference type="STRING" id="983965.A0A2T4CCI3"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="242"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="561" mass="62706" checksum="AE88F49CC91FEC8B" modified="2018-07-18" version="1">MSSPEIDQAAVNETLLERRQVLTDGLKSLPYDLVLYLERAVVYADLGYPDLAAGDAYRALLLADEVLNDGFEYHDQAKECLARYNGELLPDTVVYGQLAEEYPNLANGTPGDPDVTSEQLARLASIRAYQILSLNLLLCGCLRSALQFCERGLAAAPHNETLLHTKRHIDTAARQKLGQATYDVDDLPDFGLVRREVYPWNDHEPDRFAPESLRALNDGLREMAPKCAVQVATLPVLLEGDSDTDSYDSIPLCKQLGVFAVEDIEPGEVVLREYTLLTANNRHKDSVCDACSSELAPLGSENQSIQCEECYDTVFCSQECYDQAQSRYHPAVCDKDVDSIAKDPSAFEADETLHLLLLARVLAMAVNEDVHPLDVKEVKFIWGDFIPSEANEIDVSPNAGPPPEWTLPFSFKYNIETPLHILEKMDIDIYANLMEYDLWVLNTLYAKFRGTASARKNPRDGRPDVAAVHPYWCLANHDCDPNVTWEWSGRMVLTARKERVVGNRPGGIKKGEEILNHYCDVNLPVQQRREWARGSLGGWCMCNRCRTEASENKTADTGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCX4</accession>
    <name>A0A2T4CCX4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCX4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="184" mass="20291" checksum="B036FBBE1F039338" modified="2018-07-18" version="1">MTRSGSVSTGNVRVPVPSVWQPRNCQHAAGVRANCDHRRTPSSAGMLPYMDDGRGHVRHVEHSWALLLTQKERVLMLQQEEDETDADSGGYTNPSDENSSYTYSTRIRCCRPQFWWRQASTKYSIARLPPSGTLLPLTCFNLPEPLPRNNGFASAAAAPNGALSISKKAEMQDAGPYLDPDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD83</accession>
    <name>A0A2T4CD83_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1327083</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD83"/>
    <dbReference type="STRING" id="983965.A0A2T4CD83"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="505"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB79531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="772" mass="88629" checksum="D56D80AE711ABEDF" modified="2018-07-18" version="1">MKFGEQLRSSIIREYQWYYIDYNGLKAELKAATGPLAADGSGHKQWTEDDETRFVAKLEAELEKVHTKQQVKAMEISRRIAVSEREVKEVVNRLNERGPGEEGPSEEEFMLLEEDLSDIIADVHDLAKFVQLNYTGFYKIIKKHDKMTGWHLRPAFDTRLKAKPFYKENYDASVIKLSKLYDLVRTRGNPVKGDSAAGGSQASFIRQTTKYWVHPDNVTELKLIILKHLPVLVFNASKEFEQQDQAITSIYYDNPDGFPLYEGRLKKTEGAEAIRLRWYGGMKTETVFVERKTHREDWTGEKSVKARFSLKEKNVNAYMRGELLPAAIFEKARKEGKKSEKAIAEDERLAAEIQYSVLKHGYKPVCRSFYNRTAFQLPADARVRISLDTELTMIREDNLDGRIRSGDNWRRMDIGVDYPFSQLPPEDIVRFPYAVLEVKLQTQVGQEPPEWIRQVIASHLVEAVPKFSKFIHGTACLFPNRIKLLPYWMPQMDVDIRKPVTHDFGIRRPDISGTTTTSDDEEEELDSDDEEAEAARRGAGNGESSRHGARLRVPASDTEGQTVDLPTANEDYPIYDSDDEYDENYELEEARRVGGWHYYRLLLASKAGAAASGAWNALKWVVPRPRATEMPRAARLQSLFGDQRIQHKRFSAPPGKKIYVPVRVEPKVYFAAERTFLGWLEYSIYIATIATTLLNFGDHPTPTAFWIAGIFTLLAICSLLYSVGIYFYRSWSIRNRKAARYYDRWGPSALCAALFVAAGLNFVYEGRERKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDF7</accession>
    <name>A0A2T4CDF7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1428887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDF7"/>
    <dbReference type="OrthoDB" id="4873625at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015444167" evidence="1">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="142" mass="15628" checksum="4879F8131BD54A80" modified="2018-07-18" version="1" fragment="single">MFGLKNVILLAVAALAQIGSGSPTGQAEPPIPELARRAPNTIWIWAGPNYTGPSQSLTYNTVNECHAIDWQTIGSIWLPDNVVCTFTVKPGDCQDDVGNFRSQTIFPSGLADIRQWYEPRKADFPAYWFHNARSIQCGGANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEG8</accession>
    <name>A0A2T4CEG8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1325446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEG8"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="540" mass="57663" checksum="201793B408ACBE7A" modified="2018-07-18" version="1">MLDDKTSLDGEGRRDEEADSDPDLESQLSTSQTAASNHLALELTPSSVPHPQSLAVEIPFVVTLCLAQLLAQAGLAQCIAPLHIIGDSFGTQDAGQLSWMPAAYSLTVGTFILVAGRLGDLFGHKTIFVIGFSWYALWSLLAGVSVWSRSIVFFDVCRALQGMGPAFAVPSAVAIIGRTYPPGRRKSMIFSMFGATAPGGFVLGAVFSSLFAQFVWWPWAYFVMAMVCALVATAGVLIIPHTPGAAGLRSQAPLWKIIDVPGAAAGVTGLVLVNFAWNQAPVAGWSTPYVYVLLIVGFLFLGLFAWLETRAAYPLLPTKLFSGHLGFVLACIAAGWSSFGIWLLYLWQIVEEVRGYSPLQGSAQFSAAAISGACAAFTTGLILGKVRPSFVMFMAMTAFTVGGILVATVPAHQVYWAQTFVSVVVMPWGMDMSFPAATIILSEALPKEHQGLAASLVNTVINYSISIGLGIAGTVQSQISPGKSEQEILKGCRSAFYVGIGLSSLGVVVATMFILDEHRRHVRERRSGKKQNHETTTTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEK2</accession>
    <name>A0A2T4CEK2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEK2"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="68"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="42416" checksum="461077361DFDBBD8" modified="2018-07-18" version="1">MSTSYCLLEAAPSTSSRCIGSRTPPARNLKDVEDVLERAQRVQFIQEQRIEELERQLLASRRENAAVFPFFSRLPPELRCQIWKLALPAQIFRPFRFLQPSFLEWKSLAPPTITGVCREARDVAYRHGALYCHEFLAPLCWTWFNGHTDMLDLSPFKMKKESQFIPLQKKLLQETRATMLDAETVDDLLLTGLFGEDSQLPNVSTIHLMAGNTFQVDKQSWHPHAVARLFGGQSFVHVDIEDEQEVARLDRLLLAAMSGADGSFMSKWEKEAITRLQAQVRPSADKMKPWKKAKQLVMQGWISHNGEAFPKDIPRSCIGDDGMMKEDEVRKLYPHMPVVKLVQAFELAPVPQLAKWYKQCGRQMMEDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEV6</accession>
    <name>A0A2T4CEV6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1110707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEV6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="88" mass="10540" checksum="AEFF54F413FAAF04" modified="2018-07-18" version="1">MILFILCCLLRGEQVRDRYSFFPPGFPLRFSCIISIFFFFYLVKDHHLRAKEGNESQKGFAFRSLNSPMSFVVTFWSWGTANNLWFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEY0</accession>
    <name>A0A2T4CEY0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEY0"/>
    <dbReference type="STRING" id="983965.A0A2T4CEY0"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="567"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="821" mass="91880" checksum="D854C08E114A412E" modified="2018-07-18" version="1">MNDNIPTAVASSLMKTDTPPRKDEQQEARSAMRKGGQGEPSGRSQQGPLQEQHQKGQDQQQDHDADAAPPSQNLREYLSSCHSMNQAAQSLTLDTSASEKTTVAPEGKVYPQRIVPSPDFMEKQMGVWEALLPHKDSSFLQKLFPSIEQVHNKYFAMEHINGRMALCVSERLGTSAAVITLLQQVMDDAVLKQAVELEGKLTYGPLEGDPALGALEESSFEYDLPGFQRHCSFCVYSNVNSCRPVPAVAIEYRPSDLPMVQEVTAALAGEINPQSDVIGKQDENFTFDSSSKQTVTAIITQLYDCMVRCGVAHGYVYTGVAIIFLEIQQDPSIVHFYVSVPDDDVSVQEESGVYYSAVGQIFAFMMRAMQAGRMPNEWHNKAANLDVWRSDYGEVLLNMPSHESPRSSSPATSDGEEEMVDEDTEYEQEEDDGEVLDDEVDDDDDVEEESYVAIEIRFKLSPDGFLVPEDDVGQPSEQVDNDQSDDEDAIVDDGTRTCWIGKDNRIIVSEIRRREYCTQECLLGLTSGAPLDTGCPNVRMHGEKHLNNIEFLRLVQEQLTAARSTGSNCIYLNLSGSMGVLFKVTLAPRGYTFVIKAVVEENVSRLLREGDMYTRLKDLQGGCIPVYLGILQLNLPFQHMAKHYTHFMLLSWAGRPVKSYWGSPCNRGFVRSTQRAYEELHDAGIIHRDAKLQNMLYNPQSDRIMLVDFERSSAYRCRLKQAQHRKVDGSDSLDEERNRGGDHECNSDCEFVVDAVEQEDIGNSSDEDLCDACNRSYSSSSCGLRRVGKCENLRKEFEAASGQELSRAVNLMSCFAHKYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF38</accession>
    <name>A0A2T4CF38_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">M440DRAFT_1113814</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF38"/>
    <dbReference type="STRING" id="983965.A0A2T4CF38"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
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</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
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                <person name="Druzhinina I.S."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1634" mass="176438" checksum="221102141BA7D1E7" modified="2018-07-18" version="1">MSPGSRATRRPCSSEENWNLQTRLQEMNGQLKEAFDREKKLDHALHASNAAKAATQKELDDVKLSLSKLTEEHASATRHYDIELGTAKRAIAMADGERSAMQRKIDELTSQNLELAKAIAAQRAKAQERESSSGTSDEDLEASAVDITPEHSPPQSPMKGTTPRHAMLETETLKTSLQHAQRTIQSQRSQLHREKTEKLEFRRIIQDLRDDLEKARNELEKGPALPPVRRGRRVEPKEVKVRPPRLLGSFRSSRQEVVIEEPVAMEDPEWEDTQDVSPRSSGLRAGTRSPERRHLQQQQQQHLRRQHGYQSGDDGEELVLDSIETSDQFESAAEEVGGDSAFETAHEPSTETEDFQTGHEDLSDESDAPTEVALSVRGFGNMRRPPSLQPGLPRHAQRESFDSTASTSTEDDEFPEYNEFRTPTAAASLRRMRMNNRFSQSRRSSRQESEEPQFQSPGASFSSGGGDPATPGQSLFAELQDFGSDDESIAYTPSRRSLRSMTPASTRRALTPPPAVPRLPRVIMVDSGVMTDPVDFAPSIDPLDHRASRGSLLSVGEAARRPRSMESVIPNTDFRASTASWRSAEDAPAGSRPASMVAYSDAGAQYDIGEKLAQFPVPPSSRSPSEPDVMPLPAAAPAPPAVLNLSAIQSEHPDVPPPDLTLSSIFAHALEPQAEPEVPPPELTLSTIVSEGLEPVVEPEVPPPALSLSTIVGESLEPVAEPEVPAPVLSLSTIVGEGLEPVAEPEIPPPVLSLSAIATEGSEPVAEPEVPAPVLSFSGIVAEGLEPKAEPEAPAPELTLASILSEEIEPVVEEPEVPELTAAEAIAPEAPAAAPQELSISPIVAEQVEPVAEPAPEPVRIIMAPPPAPLSFSSIQAQQLEPRELWLPTLTLSTIAVEKVEPVVETETKPEPASAPLTLSSLSFQNTIPFDELPIDDEELLLPPPQPEVQPKEPQAPVLGLSSIVAEDVEPVFPLAPQFAFSPISSVDTQPISPTKRGGFILPKDVKSPFIDDGDDEISDKNLFASYVTRRRPESVPSSPIIAEDETSQSRPVSPKVDVPESQRPFREISANAGSKPAQQLSHTSDHGAQTSLTSGAIDELLKAGAETPAKNHSASAVESPDTVGTVKINRASQENHDSPVSAVPSKSRTLEPAAVIESTPAHRPGSATSAKSSLVGAPPLPPNHQQMIQAARAGSSHGSQGATMGPPLWPASATKPAPRTPNSTRPMSPASGRGTPTPRAPPPRAGSSHGTAEYPPPPPARLSAAMSRQSSVSSFASEIDNRFGMRAGDMGIDPSGFGANTDPRMIQAITQTMIGEYNWKYTRKAGRGELSEKRHRRYFWVHPYTRTIYWSDRDPATAGRTEMKAKSLPIEGVRVVTDDNPMPPGLHRKSLVIISPGRTIKFTCTTGQRHETWFNALSYLLLRTSNGHDGHDDAEEMAADLARDDADEFNPQFGRRAVNGASRPSAPSLSSYNSRTTRDGSLAEPISFEIPTLTPSGKHASHASHGSHASTPIKPSISGSISSRVGSYWKVGGSKLSGTIRSRTASAQNVSIYQASEVHDSAEDLREMLERQDMEADRLENVRACCDGKHDVGTLPHTTKRARSHNHSHNHHHVQSSGQSALSMPLSSTRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF93</accession>
    <name>A0A2T4CF93_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1397534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF93"/>
    <dbReference type="STRING" id="983965.A0A2T4CF93"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="104" mass="11398" checksum="98CE5FA10BA49FC2" modified="2018-07-18" version="1">MPQILRLAILECEKLLPKAKAARGSFGDIFHDFFAQGLQDLGPEAADVRLDVSKWDAMAGEYPRIEDVDVIALTGSCMSHSPLSACSFCNLLLFRYSGMSKTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF96</accession>
    <name>A0A2T4CF96_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1460238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF96"/>
    <dbReference type="STRING" id="983965.A0A2T4CF96"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015467997" description="RNA-dependent RNA polymerase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="4">
        <location>
            <begin position="373"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1189" mass="135085" checksum="473921C1DE97A69D" modified="2018-07-18" version="1">MHCAWQLLCLLCLLCLLCLLWSALLGTMSRQQGPGRWLVSRAHPDSEYPARITASLSSLDFGSLVAPTSINVRKSIPSRGGSTISMEVDVLAKRLIILFPLRVKKNANTYETRHFKILAELAQAKTIFKSSQEDGCDVFTFPFSIPPQYYWRADEAQRALPNTRAPGWRPIDMWRRATDISEDATRSFTFPVAADSTHIDPHFFEVGRWTALRVVLSKSDHSSKLAASHLQLAFEDRNINMQVCDDFRVSHSAVTMWDFLDHHHHHHAGSQGDALALLQPSRYPFVHLEFGVRYQLEVCVGRRLLNEHTVSLEFLQGLAALDPLDAKRRLEYLADQGDVMYDPMEVLNWAAAASYTPNTRIPHYCVLARKAAVTPTTMLLSTPVVETSNRVLRYFNHIQDRFLRVQFVEETEMGRMAMSCRNKEDVWKRILRTLYHGTQIGDRNYQFLAFGSSQLRQCGAYFFCPTDHISCDDIRRWMGDVGHIRVVAKYAARLGQCFSTTREMRGLPIPDVRAVPDIERNGYCFTDGVGIISDFMAQMIFEEMTLDVYTEPSAFQFRMGGCKGVLVVWPQAKKGEVYIRQSQEKFKAEVKNLEIIKCAKYSSATLNRQTITILECLGVTKKAFLDILEKQIRLYEEAMGKNEVAIEMLTNFVDENQSTLILSEFLQAGFKTDKVQEPFVANLLSLWRSWSLKLLKEKARIPVDKSAFVLGCVDETATLRGHFNATEGSSEKDISKLPQIFLQVSDSKIYNKMHIVKGLCVVGRNPSLHPGDIRVVEAVDVPALHHLKNVVVFPSTGDRPVPNMLSGGDLDGDDFFVIWEPTLLPEIWNHPAMSYSSPPPETLDREVNVDDLRDFFVKYMKNDVLPLIATAHLALADRFGPLSKICLHLANLHSQAVDYPKTGQPAEWDAAMHNPQQWPHFMEKKNSYTSPKALGDIYNRVKQQSIHFQPHWETAFDRRILSKFELDNATLKEARRIKSQYDGAVRRILVHHNLETEFELYTSWAMSKPPMGSEYKRQEDLGKEFDAVKQRFRDACIEAAGSHDEAKLDRFVAAMYKVTEQEVKIALFEHHRGPTNEAGVVKPARELQARSMPLISFPWMFPWVMIRIATDGKCKPKDSVLAAAHRRVPVAVPSFVPLTQQEGDEVSQDVKPKQSASNDGEEMEMPDPEEETALQQPGILMELGDLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFB5</accession>
    <name>A0A2T4CFB5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1435902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFB5"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="795" mass="88669" checksum="87820F4EB4BC2D61" modified="2018-07-18" version="1">MGFRFGKSDARVEAEAVSSGAEVLPVESHNVESELRNFRKQHRWDPFLDIDKLDNIDEALASGNVEKEAAIDESLIQEDSPYPEVRASVPPTDEDMPVDTIRAWVIGAVMCTIVAACNILLTLRRAPITITSTVVQLVSYPIGCFWARVMPNYTFTLFGHKFELNPGPFNVKEHTIITMMTAAGTAASYAIDILLAQEIFYNQKLGWGFQILLILSTQAMGFGVAGVARRFLVWPSSMVWPAVLITTTVMYSLHDHSAADPAMTNGWKIGRYSFFLIVAAGTFCWEWVPQVIAQFLQLFMFPVWCAPENTAINMIFGGNTGLGLLPISFDWSIISGFLLSPLQTPAFAIANVAAGIFVMLLGIIGLAYAGPEFYRYLPLSANQNFDHYAQPYNTSRILNPDYTVNLTAYREYSPILLGPAFSLSYGMGFAGLISTITHIVLFYGPDVWRRSIDSRSEEPDIHMKLMRKYRETPELWFISIFAVSFGLGMAASLAWPTHLPAWAFVLCILIGLFFFIPVGMVQAITNQQTGLNIITEMIFGYMLPGRPVAMMLFKSWGYMMTYNGLTYVSDMKVGHYMKIPPRSMFGAQAFAVIWLSIVQIAAYNFLLGNIDGICTPEQPQGLTCPNARTFYNASVIWGVIGPKLVFGAGQLYSWTNWFWLIGFLCPFVQWLLARRYPRSMLRYIVFPALFGAAGMIPPATTWYLAQWCIVGLIFNWWVRRRWLGWWTQYNYVLSGALDIGTALCTVLVGLSLGLGNATFPDWWGNTVINNNLDAQGAAVLKVAPTSGPGIGPTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG25</accession>
    <name>A0A2T4CG25_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG25"/>
    <dbReference type="STRING" id="983965.A0A2T4CG25"/>
    <dbReference type="OrthoDB" id="5232836at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="921" mass="101107" checksum="F6B6C3B39CF79B00" modified="2018-07-18" version="1">MAPSTRASKPSAETPYTGAITRSRAASQKQEQQQRRQQQRQQQAPQKLRRSKRKRAIDADEDDDEDKDGDDNDNNAAPKDKSPPPKRKRGPNRCKFCGADPVGKDMFQERPCDYTKIWKENFIECQNCADHRSKNPGIRHKCQPPNVNKVWRQYGVADPTTYTPATCDACRGGRLEHQCNVDPILGYGCTTTRACREGTCTVNGVPMEKPPRPQANVVRWTRGECHVCENKTKKGTATVGCSWLRDRTTWNQACEYCQAHNLVCMSGGNIVASPANLTLPKTWALNHQVFDWGFIECRAIGPHRRNCKRCREDGHEHCRVDAGAYGFACNRCAQLGIDCIDSKDGIHYPIFDLARVGIGGFMPFPECSCCTRHGRNCDLQRPCDSCVKHGDECDAFRGVTARYCFSGRLDPPPGPLYYLALGYGPQGVDDPKDGSAIEHWVGPATNVYCMLPDKQKKEYLTALGAHLRAKLHPPGGPPHGDVSQGGLLVRRASEITPQQIAALIKAQWPQARPMNQFNVYQRYVDEAQQQAQLVRAGRAGMRIPEIPANEEDDADDDDNGGNGDGNDNDNGEGGSGNGSGDMLMGNAAGSDDEERVRINAAGIAAARALALSAIANPPRPAPPPHEVGGDNSRWLQGFVSHDSIVTDGTNVAAATQWGNPWLHVPTQEQFDYDAALHSGQMMSDVNFQTFHVPVSHSNWNFHPDPAFSQGDIDFNPFGAPAPDPSMGVNTNLGSYAVNPEFNPFQVPNPEVDMDVNGVNFDNVNVDDINVNNINIDDINAINEADISANDIDAINAVNIADINFNLDDDLYTDFNPVPVPDTDDSAEMDIDFDLYIEQPNFDPFRADDEPSIDPNTDPGIDSFFDPVTEPEVQVGTEHSVQTGTDPSTGLLDTPNLDDAMMSLLMPYMQDDESAEGHGWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGB9</accession>
    <name>A0A2T4CGB9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_358879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGB9"/>
    <dbReference type="OrthoDB" id="5343483at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="322" mass="37472" checksum="AE7B0FC6813753A9" modified="2018-07-18" version="1">MAPIRRSSRLAPPSRTSPPWETLPLTQLIQQRCRERVLVDPLEWTDVHLELLQCRFEEAPSTRLRKEHEDKVDKMLLPPKYPRAVEALSTDEKAWGRESLIRTIISSNGSPLFRGGDPIAFQYNRTLVRELPGCQGFISSRYSRDEAWRTAWKAPIALVTIDREALELHRFEQMEPYRGRRWSQANRGVHLRHVRRITPSNRLRDPYLVAILIAIAAQQREKTTSRIRSKASYWPQVLMTDRGDECVHLFAAHISSDYLNKFDFPSSEPPKSAQHPLVVHHLPLQIKPYDTFRRRLLTILLHPAEYYTGVPGPKSSRPVWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGH0</accession>
    <name>A0A2T4CGH0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1348810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGH0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGH0"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000048">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="176" mass="19988" checksum="56F4351D8FBACA93" modified="2018-07-18" version="1" fragment="single">MASAGAAAASLLKRQLKEIQTGKDLPGISCGLVNDSNMFEWEVMLMINDDCKYYGGGNFRARLVFPENYPHMPPSLTFQDPIPFHPNIYENGTLCISILHPPEEDQYGYESAAERWSPVQTPETILLSVISLFYSPNEESPANVEAARMLREEKEGKHKEYRRRCRKCVRESLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGH1</accession>
    <name>A0A2T4CGH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_200624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGH1"/>
    <dbReference type="STRING" id="983965.A0A2T4CGH1"/>
    <dbReference type="OrthoDB" id="5279415at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="474" mass="54347" checksum="2FEFA859E4519348" modified="2018-07-18" version="1">MAGQLVFPWECRDKEDQAWAAYNNPLRRTNQLLVEENMRLKRILRENGISWSPLAQNHLNQSDPTRRKTRSATAAGLGDASSPFLPTEVLLRILKFAMKSKYPIIDPLSPVTVENLTDEEKKRGNQIAIHFLATCKAMHAEGTRVLWESNHFVFTTPQALRNFSELSFNYRHKILHINLRIIARYYDDQRRRHKLERYYHPDLKRDQPLKIQMRPKESPLVRGGFRCYTWNQVIDFLLALRAPYDPNYKDKKNPRPRLLPSLSSLRLDLVNFSDSLLPFSGSELHEVASHELGCTLNELQVTGMPFDDVGMKASAELSGLVKDEGLYLDASAAFIALPKGLQSLSGDNWCARVIRAYKDLKEEMEEEGIGFGGDEDDDEQFHLHSFEGYHKVGTLPAAPSEEGHPPSTREEKRVIWKKVPVARESDKRIWIQFSRLNGYEVEESVWDSEDDRICPCCGDSHPGSSIFGLMSDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI07</accession>
    <name>A0A2T4CI07_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1387628</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI07"/>
    <dbReference type="STRING" id="983965.A0A2T4CI07"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="463"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="856"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB81152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1212" mass="133789" checksum="F11441FD4453A60A" modified="2018-07-18" version="1">MATTSNMFLYSLTIQPPTNVVQAVLGQFAGTKEQLIITGAGSRLALLRPDPSQGKVITVLSHDIFGIIRSLAAFRLAGSNKDYLILATDSGRITIIEYLPKDNRFSKLHLETFGKSGVRRVIPGEYLACDPKGRACLIASIEKNKLVYVLNRNSQAELTISSPLEAHKPGVLVISMVALDVGYANPVFAALEIDYTEADQDSTGEAVRDLETQLVYYELDLGLNHVVRKWSEPVDSTASLLFQVPGGNDGPSGVLVCGEENITYRHSNQEAFRVPIPRRRGATEDPSRKRSIISGVMHKLKGSAGAFFFLLQTEDGDMFKVTIDMVEDDEGNTTGEVRRLKIKYFDTVPPAASLCILKSGFLYVASQFGNFSFYQFEKLGDDDEELEFTSDDFPVDAQASYDPVYFYPRPLENLVLVESIPSMNPLLDCKVANLTGEDAPQIYTICGNGARSTFRTLKHGLEINEIVSSELPGIPSAVWTLKLNRNEQYDAYIVLSFTNGTLVLSIGETVEEVSDSGFLTSVPTLAAQLLGEDGLIQVHPKGIRHIRNGQVNQWDAPQHRSIVAASTNAHQVAIALSSGEIVYFEMDDDGSLAEYDEKKEMFGTVTCLSLGEVPEGRLRSSFLAVGCDDCTVRILSLDPESTLENKSVQALTAAPTSLAIISMEDSSSGGSTLYLHIGLYSGVYLRTVLDEVTGELTDTRQKFLGPKQVRLFQVTVQGRTCVLGLSSRPWLGYADPITKAFVVTPLNYVDLEWGWNFTSEQCEEGIVGIQGQTLRIFSVDRLGDTLIQSSIPLTYTPKKMVKHPDQPLFYVIEADNHTLSPALCAQLLADPARVNGDSKVLPAEEFGHPRGNRRWASCISVVDPLAEDGQVLQRIDLEENEAAVSLAIVTFASQENETFLVVGTGKDMVLNPRSFSDAFVHIYRFERDGRGLVFIHKTKVEEPPMAMIPFQGRVLVGIGKMLRIYDLGMRQLLRKSQAEVAPQQIVSLNAQGNRIVVGDVQQGITYVVFKQQTNKLIPFVDDTVARWTTCSTMVDYETTAGGDKFGNIFLVRAPQKASEEADEEPAGLHLLNARSYLHGTSHRLDLMCHLYTQDIPTSITKTSLVVGGQDVLLWSGLMGTIGVLIPFVTREDADFFQSLELHLRAEDPPLAGRDHLMYRSYYAPMKGVIDGDLCERYALLPNDKKQMIAGELDRSVREIERKISDIRTRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI89</accession>
    <name>A0A2T4CI89_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1012258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI89"/>
    <dbReference type="STRING" id="983965.A0A2T4CI89"/>
    <dbReference type="OrthoDB" id="5240751at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="424" mass="43904" checksum="8CD12BF60467DB5D" modified="2018-07-18" version="1">MAGLATGNAPTSTEFSLLPSEGVDPNGPGVGGGPAGGDGGGTISSEAQGMLPTSTHMNILPSASPTNSFSSLSSPKVLVFNDKANFGPNSTGRVFSTQSQTKTFAWTYAKSNTTLLDIFWYGRKVNTGDAFDVSRASVIAHAKFGDTTPGNEFAKLNPSDAMLNLTGPGLSTGEWYTREMVIKIDWKTQGGDEGFTQSGVFTVANGQFDSDAFGREATDNNQDKQGGEATTSIGNPSLPTSGPSDTGNGIGGGSSGSSRGGGGGGLSTGAIAGIAVACSVIGILLIAGLVWFLLRRRRRRHFDAGYNATHQTTSSFIAAKEARPSVVESPVISPFSDNDHSRAIGPISGSSAMPIPLHHAPGTTAADPVSPADDRPSTATSGTRARNIAHLVEEGMTEADILRLEEEERHLDAEIERAARRTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIR2</accession>
    <name>A0A2T4CIR2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1427293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIR2"/>
    <dbReference type="STRING" id="983965.A0A2T4CIR2"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="317"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="553" mass="62924" checksum="7866D8FD850829CA" modified="2018-07-18" version="1">MPTSAQDSAKRKRPSTGDKANKVVKRRRSSNDDAEDPNAKILLMEQGILESKKNYNDIVTLQSIASRYENGEEESMLAAVALCRIFLRLLVQGSLVAKKGLSEKDTVVVGWLKDQFAQYKSLLQKMLADEDLAATALTLCMRLLKAEGEHLYDKEEYTFPYAFLENIVEVLIMSGNEDVRKAFLESYVEQYDDIRYYTFRAVKAILDRLDKDDIPDSLFGHVFDLLSALDGVPQSAEELEDFYVPRPKKKSHNLRTVTQHKRQGQDAWLAILSIVRTKEERKRILNVISTNIAPWFTKPELLSDFLTSCYNTGGSMSLLALSGVFYLIQQRNLDYPSFYPKLYSLLDKDILHSKHRSRFFRLLDTFLGSSHLPAALVASFIKRLSRLALNAPPSAIATVVPWIYNLLRRHPTCTFMIHRPAQDPELKKHIQNNGFEDVFNPTEPDPMKTGAIDSCLWEIVQLQSHYHPNIATIAKIISEQFTKQSYNMEDFLDHSYASLLDAEIAKEIKKAPVVEFQIPKRIFLPQDEPATNPDSLLVKLWDFGEPAKGVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIS0</accession>
    <name>A0A2T4CIS0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1445-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIS0"/>
    <dbReference type="STRING" id="983965.A0A2T4CIS0"/>
    <dbReference type="OrthoDB" id="10262538at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="33634" checksum="04EF47DA10DAC1CC" modified="2018-07-18" version="1">MIKTSIVTGLQARLASRNGIHTSSTSGLAPGHLQANLIILPSRYANDFRTLCARNPVPCPLIAESAAKGCSDAFVSHMKNLRGQDILGPGSDVRRDAPRYMVYRDSKLEKSHCEDVTAEWTDDHVAFLIGCSYSFETALVEAGLAPRQLMQGRNVPMYRTTMGLCAAGVFRGGTYVVSMRPYRRRDVERVREVTRKFGTMHGEPVDWGWDAVRRLGIGDIDGPEWGDGPLDEGGVMGFGMARRERLLRKDEVDGEDEEDEEVPVFWGCGVTPQEAVMRAGLEGVVMAHAPGHMLVLDARDEDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ23</accession>
    <name>A0A2T4CJ23_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1367744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CJ23"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000249">
        <property type="entry name" value="Lysine-specific histone demethylase Aof2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="905"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="1651"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="1651"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="731"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1740"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1785" mass="197240" checksum="8AE768A99C9A0C99" modified="2018-07-18" version="1">MAPRAEFSTEQVRGKARKDLLYLLEGVRGKKNLVFDRSLVGPIGTIVKVATLQEYGVDKFFILENNNVDASQRNVVFVARGECGRHAEAIAAQIKRIQRESQTTHDFHIFWVPRRTLVSDQLLEEAGVLGDINISELPLLFFPLEDDVLSLELEDSFKDLYLSKDITPNFLMAKALMEVQKNHGLFPRIIGKGDHAKRVADLLVRMRQERLAGEDGSDVKTALTPSTTNESVIIIDREVDFVTPLLTQLTYEGLIDEIFEIQNNQAKVDTTIVGAPAQSSTATSQSRKRTVQLDSSDKLYEQLRNANFAIVGGLLNKVARRLQKVQSDYESKHKTKTIAELKEFVGQLPGYQQEHQSARIHTGLAEEIIKHTRTDLFKGLLEVQQNLAAGADPSSQFDGIEELIAREAPLRETLRLLCIYSCISGGIKPKDLEQFKRLILQGYGYQHLLTLNNLEKLQLFLSRSSPLAGMIPMAASSGGDGTKTNYTYLRKQLRLIVDEVQEDDPNDIAYVYSGYAPLSIRLVQCILQKQYLLSITKGNGAANASGIAPGAGTQGWHGFDEAVKHVRGQTFYELQKGEDKAVKARALLSGSGQKQTVFVVFVGGVTFTEIAALRFIAKQEESRKKIVICTTSIISGNRMMDAAIEKEAFARKEPTASEPPNDLSSRLQRFLGSGIIYTASSCGRSLHHMMRLPSAMLLEKKVPIGPTFSHATQDTDTSSSISSLAAESVAKSQSQVPASPRSVLSSRQVSGQGSSDESSEVAPEIVVWTEDMETEEMDLSSGLSNHDTEESSGMQLDTDDEKLQLGDDVPLPAEPTEDAVAESFTSSHSSLSDLSEVLSSPSIVSSKATTPIETEIPSRPQIDGLAQTYSASTSYRHDIERLTFNVRPKSSIPTDIPSYQYASECIAAAESSRLNPYALHPEEYQFLRHHISHSQVTTYLNIRNGILRLWMKQPSVGVTRQEAVGCANARWFDAASVCYDWLVRRGYINYGCVQLPEPQPDFRNEPPTKKRKTIAVIGAGISGLSCARQLDGLFKQHASHFYSRGEEPPKVVILEGRGRVGGRVYSREFKTRPAASEPEFKGKRYTAEMGGMIITGFDRGNPLNVIVRGQLGIPYHALTADTTIYDSNGKPVDPVRDLLVEKLYNDCLDRVSEFKYKYQPSKVIEGNRDLLDEGRDSLGDGSKTIMQAEEATAALPDAPSVSQQNVPETVNMVPVSADKLTGRVHTEPGVPGTIKASEKAKLMGWNIKAGAADKGNLDLTQATTLEGSTLGSVLDYAITQYKNIVDLNAQDHRLINWHIANLEYSNATNLHNLSLGLWDIDAGNEWEGPHTMVVGGYQSVARGLLQCPSPLEVKTKFAVQKITYHGDGFDGPASIESEDGTVVEADAVVCTIPLGVLKQGTIQFEPPLPAEKADAVRRLGFGILNKVVLLYDRVFWDSDRHIFGVLRDAPNRHSTSQQDYSTNRGRFFQWFNVTNTTGLPCLIALMAGDAGFDTEHTSNDSLVAEATDILRSVFGKDVPYPIETVVTRWGSDRFARGSYSSAAPDMQPDDYNVMAQPAGNLFFAGEHTIGTHPATVHGAYLSGLRAASEVLESMIGPIEVPTPLVLPRDSLLLHKRKEAAKDPRQARLEAYEIEVWEHVLSKIGERPLRPNKVAGSAYILFSKAHFEAAKKRCEENRKPGRSRSIPNEVRIMTSRMWKEATPEQKRPYEEQVAEQKKRYLEAMQEYNELAEKWDRQAMALRAAYEEEHPSVPGPEEGPEDGSTMAQKRRAKNVSYAEGGDTDADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ97</accession>
    <name>A0A2T4CJ97_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_89029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ97"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ97"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="202"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="251" mass="26308" checksum="418A94D2B3958B49" modified="2018-07-18" version="1" fragment="single">MLPPRCLSNPHPLAFSHGISCLLARTPAAPHHHSRRLVTLAIETSCDDTAVAVLSKSSATGRARLLFNERISSDNRAFQGINPMITVQGHNASLGPLVEKALGALRRYEEEEEHHDDAVTGMDKRSKTGAPDFVCATRGPGIMANLSVGLNVAKGLALAWGVPFVGVHHMQAHALTPRLVDALNSSSSSSSSSSSSTATATTPSPAFPFLSLLVSGGHTQLILSTSLTSHKLLASTADVAVGNLLDQTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJA4</accession>
    <name>A0A2T4CJA4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1323003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJA4"/>
    <dbReference type="STRING" id="983965.A0A2T4CJA4"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="97" mass="10909" checksum="C80622F1841F868E" modified="2018-07-18" version="1">MLRTTLTKTAAFRPLRAAFTTTARAMGEGDTGAPPKTGGAGDAFQRREKAAEDYAIRQREKEKLLELRKKLTEQQEHLDRLAKHIDDITREQGGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJG2</accession>
    <name>A0A2T4CJG2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJG2"/>
    <dbReference type="STRING" id="983965.A0A2T4CJG2"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="111" mass="12560" checksum="BD5EEF9BCC4DA663" modified="2018-07-18" version="1">MSARKTASLRGHKTASMVAIDTVLNDQIVGFALWDLPVCRDETEEQVVTPAEAELPAGVTDLKAYARFLSILQEDHETTFGERQLKDVWRVFSIQLLLPMFFLMAMENSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJT4</accession>
    <name>A0A2T4CJT4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1346918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJT4"/>
    <dbReference type="STRING" id="983965.A0A2T4CJT4"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="68"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="444" mass="49393" checksum="76163626D54171AD" modified="2018-07-18" version="1" fragment="single">MAEPSEVLSSPTFGRAFGEKHFMFKPGFTHLNHGSYGGYPRPVRDALRSVQDAVQAEPDTFVRYTYPAKLEEVRALLAKHLHAADKDEIVLVPNATTALNTVLRNLQYQPGDVIAFIQGTYGAIEKTVDYLVETTPVESVCVPFDPVSDDDDTLVETFRCVLQEHRGRVRVAIFDTVVSMPGLRMPFERLAQVCRDFGVLSVVDGAHGIGLIDLDLDRLGADFLTTNCHKWLFVPHTCAVLYVALKNQHLMRSSLPTSHGFQPLPDILQMKQYIGPYELPASNNPFVFQFSYTGTIDNGPPLCIPAAIKFRKEVCGGEEAIQAYCRALAREGEKVAVAILQTRTLPMPESKRVAFANVQLPLEVSSHDAAERGGTIPLADVPKVIDFMLRSLSRDYNTFVNIAFVSGSLWARFSAQIYLELEDFEYGAKALQELCEKVANRDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJY8</accession>
    <name>A0A2T4CJY8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1397060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJY8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="74" mass="8278" checksum="30599A1192A55720" modified="2018-07-18" version="1">MLSMLPEARNEGQYYYQNAVSHNTTPRAPRDCISANRQPAGDSVLVLGSPGMGNTVGSQIMSRPELYRQQRSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK71</accession>
    <name>A0A2T4CK71_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1459986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK71"/>
    <dbReference type="STRING" id="983965.A0A2T4CK71"/>
    <dbReference type="OrthoDB" id="5771378at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="320" mass="35646" checksum="870C0CF70120A28D" modified="2018-07-18" version="1">MPVIESTPDFTIRSATSLDEVKDLWWSRMRDLGWNRDELDAETHFTVARRGEDWLLLVPTGSVEPSGMVIGFTYPNKTGWVGFFIMNEEYRGRGWGASLFKAMLDAYRKHDIHMVGLDAVEEQVSTYARRGFVEAARIKLMTRVSVREVPLDYPEKRPKQGYGVVDLQQVDAGTIANLDRAHTGLYRPALWTRDALFSRPDAFGFAILSEASGEMQGLILVRQCEHGHRIGPLIADCKDHASLLLQLAMSNPSISASNGSLIAEAFGPNEHAAKVFSNLGWQSAGLEYHRMWLEGRVPVEQREGGQGSKGMFAVFDAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP11</accession>
    <name>A0A2T4BP11_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679184">
        <property type="protein sequence ID" value="PTB71055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP11"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="135" mass="15478" checksum="159AE1323CA159BD" modified="2018-07-18" version="1">MPQGQKEGGSVHVARDAIVAHRHHSAPPSNPARIPVHERAINGISLKKSNWKTRFEKGKKRRRRTKEKRGKREERKSKEKRKSGRQAGGEGSRKSREKEKRGGKKKEGKEDNWRKGRHDRAIKAIMTAQKNYGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPF3</accession>
    <name>A0A2T4BPF3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1426788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPF3"/>
    <dbReference type="STRING" id="983965.A0A2T4BPF3"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="421"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="867" mass="94614" checksum="EBAD14BAC904E388" modified="2018-07-18" version="1">MHLSPKSPIGTIHDWYPMNKSYFNTLQKLQLDTSHVKVPMMLVEECLHGVGSFKQSIFPQNIAMAASFDTDIVYRIGRAIGTEARSIGIHGCFSPVLDLAQDPRWGRVQEDFGEDKVLTAQIGTAYSAGLSKNKTWSDSDAVFPIMKHFAAHGAAQAGHNTAPFTGLGPRQIKQDLLVPFKANYDLGGARGVMMAYNEIDGVPSCVNPMLYEALDEWGYDGIVIGDDTALRNLLTQHRVTNSEADTLQQWYNAGGQIDFYDFDLDSKINITKALVANGTVPLKSLQSHVRKILGVKWDLGLFENPYIPEHIDPLAIVASHQDVALEAAHKSIVLLQNDNQTLPLRSSKKIALIGPFADTINLGDYSGALGQYPAKYTQTLREGVLRHANKSGHTVRTSWGTNSWEYNNQFVIPGYLLSSDGKPGGLKATYYAHTNFTSPKATRVEVPAQDWGLYPPPGLSSNNFSAVWEGQLESPTDLDVNGWIGLAIGPNSTSKLYVDGRLISSKGYSDQGNLLGTIEGYSWTQANSTIPPQGGVEFIFKKDAKHHVRIEFQSWNNYKKTANVNSVNSQLIFWWNLVSPNGEALEQAVSIAKDSDVVLLVVGAAWNSDGESGDRGTLDLAPSQEELAKRILALGKPVVLVLEGGRPFAIPDHYQKSAAVLSTFFGGQAGGQAIADVLFGTFNPGGRVPITVPYSVGQIPAYYNYKPSARAAQYLDIPSGPIYPFGYGLSYTTFSTSSPIASIRGSSKRSRDAQEGQSFGAGDWIDFSVTVENTGSVAGSYVAQVYLLGRVSKITQPVKQLVGFQRVYLEAGQKKTVSIELEVDRYLKILNRKDEWELEKGSYAFALLEHGGSNADTSKNVTLECLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPJ7</accession>
    <name>A0A2T4BPJ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="6">HMG-CoA synthase</shortName>
            <ecNumber evidence="6">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1366049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="6"/>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPJ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BPJ7"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="453" mass="49906" checksum="8FBA89219E295F97" modified="2018-07-18" version="1">MAARPQNIGIKAIEIYFPSQYVEQSELEKFDGVAAGKYTIGLGQTKMAFCDDREDIYSMALTVTSRLIKNYNIDVNSIGRLEVGTETILDKSKSVKTVLMQLFGDNTNIEGVDTLNACYGGTNAFLNSVNWVESSAWDGRDAIVVAGDIALYAKGAARPTGGAGAVAILVGPNAPIVVEPGLRGTYMQHAYDFYKPDLTSEYPVVDGHFSLTCYTRALDAAYRDYNKKEARLTNGNANGVDSSKTPLDRFDYLAFHAPTCKLVQKSYARLLYHDFLSNADLPAFAEVAPELRDMDYEKSLTDKALEKVFMTLTKKRYQERVNPAIQVATLCGNMYCASVWGGLASLLSFADSKALENKRIGLFSYGSGLAATFLSLRVVGSVETIGKTLDIATRLEARRAVPPETYDEMCNLRKQAHLQKNYTPQGDVSTIAPGTYYLEKVDDMFKREYAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPK1</accession>
    <name>A0A2T4BPK1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1386811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPK1"/>
    <dbReference type="OrthoDB" id="4882991at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38892" checksum="36B6FE985CFF7155" modified="2018-07-18" version="1">MLAQSIWAHDLSIVSIVALITSIVRSHARRYFERIIPEWSKLDEAVKSRLAVEVGVIPSRVVLFCLTLPLVLTGFSPMESWTANETARSLASCAILTGSYIVDLTVTRSDKASTLHHVMGPALLLWIRLCFSSFTSSDALLCRLLIQFVFFGATISGATTTALVFLYQFRKTWFRSSTSNAYFYFTLLLPVLAFSTIASTFYCTIYLLVWFDKIFAYFGHWGYLPLGWVLIECGMQWKWLMWFYKFEQWYRTTTYESPEESDEIKKKMAEVAAAAWWLPKWRFGAIKFLAAAWLATVLGVVWETGDIQLLTRWFASVASSAWGERPGLCLSVSKSKTHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQJ9</accession>
    <name>A0A2T4BQJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein YMR-31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1395521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQJ9"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14805" checksum="9C8031D54BFBE656" modified="2018-07-18" version="1">MFATRALRQAAVHAERTPMIRFLGPRTIPSSIDHTPRPHPASPSGKLPEGFTAYYGNGDAAARHNSFGAYRDHAQQHGPLQKTIGGADAGIGGSSGHQLGSVLPPKGVAFDVSELPARFRRRPIDMSEIEAIESGGAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQY0</accession>
    <name>A0A2T4BQY0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1395438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQY0"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015554910" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="36085" checksum="B1E704EB358E7D23" modified="2018-07-18" version="1">MMRLALLPLLTGVALAATGDATLTSTGCADSSGFESCQKQANDKLSSCIAQAKKDNSQQELLACGCQNYVDNYNCYSASCWNRVWECEYQEYIIDYFLNCPIAKLPVPYFPAPNKAPDECSCNIGKVFLAIQEAIQETATCSNNANSGDASSNLQQIQGCDCCEISGALSSLYNICPDTDPKLIGLSNVSQLQSQLNTDFNSCGSYLETYDCVADLGYSLDGVSKYYKPTDTVPSGTATLSNAAGTVTSPASGTVFSYTNGGDGTVYTITAAGHVQDSGDSDSGSGSNSDSSGSQTTGSRDAAATTASSQGSATAASPTETGSKKSGAGVAAASLYLAVVAIAVPLVACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR40</accession>
    <name>A0A2T4BR40_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="14">3.2.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">1,4-beta-D-xylan xylohydrolase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Beta-xylosidase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-xylosidase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Xylobiase xlnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1406286</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="14"/>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR40"/>
    <dbReference type="STRING" id="983965.A0A2T4BR40"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
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    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF13">
        <property type="entry name" value="EXO-1,4-BETA-XYLOSIDASE XLND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015544247" description="xylan 1,4-beta-xylosidase" evidence="19">
        <location>
            <begin position="21"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="694"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB71769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="797" mass="87302" checksum="0259E157D09B6E7A" modified="2018-07-18" version="1">MVHNAALLTALSALLPRALAQNNQTYANYSSQGQPDLYPETVATLTLSFPDCEHGPLKNNLVCDSSAGYVERAQALISLFTLEELILNTQNSGPGVPRLGLPNYQVWNEALHGLDRANFATKGGQFEWATSFPMPILTTAALNRTLIHQIADIISTQARAFSNSGRYGLDVYAPNVNGFRSPLWGRGQETPGEDAFFLSSAYTYEYITGIQGGVDPEQLKVAATVKHFAGYDLENWNNQSRLGFDAIITQQDLSEYYTPQFLAAARYAKSRSLMCSYNSVNGVPSCANSFFLQTLLRESWGFPEWGYVSSDCDAVYNVFNPHDYASNQSSAAASSLRAGTDIDCGQTYPWHLNESFVAGEVTRGEIERSVTRLYANLVRLGYFDKKNQYRSLGWKDVVKTDAWNISYEAAVEGIVLLKNDGTLPLSKKVRSIALIGPWANATTQMQGNYFGPAPYLISPLEAAKKAGYHVNFELGTEIAGNSTAGFAKAIAAAKKSDAIVYLGGIDNTIEQEGADRTDIAWPGNQLDLIKQLSEVGKPLVVLQMGGGQVDSSSLKSNKKVNSLVWGGYPGQSGGVALFDILSGKRAPAGRLITTQYPAEYVHQFPQNDMNLRPDGKSNPGQTYIWYTGKPVYEFGSGLFYTTFKETLASHPKSLKFNTSSILSAPHPGYTYSEQIPVFTFEANIKNSGKTESPYTAMLFVRTSNAGPAPYPNKWLVGFDRLADIKPGHSSKLSIPIPVSALARVDSYGNRIVYPGKYELALNTDESVKLEFELVGEEVTIENWPLEEQQIKDATPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRP5</accession>
    <name>A0A2T4BRP5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1102903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRP5"/>
    <dbReference type="STRING" id="983965.A0A2T4BRP5"/>
    <dbReference type="OrthoDB" id="5425782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015568198" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="4">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="319" mass="32153" checksum="06A49204EF5D2E59" modified="2018-07-18" version="1">MYSSRLVSVLVVVVSILCLVQANWWDVQKVHHRGLIRRADLSDVVGDLKKSTSADDSLPSPAPPSQSPSSTPAQQTTADDSSSSTSASPSSPPSTSESASATPAPGSTSSPASTTAEPTTSAPDSTSSAGPTPSATTPPSTTTSSSGGGSDDSSSDDSSSDDSSSDQKTSDGGNGKGGSSPSETPSAVVSTKVEVVTMTNSDGSKTTQTTTTKTTHTAALNAENQKPTGMSTKTRNTIIGVVVGVGGAAILGALILVAFRVWGRKKHAEEADGLMAYNSDLVAGAEKSPRGSSSGAGQRNPFQSTLENYHQPVNASANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSF8</accession>
    <name>A0A2T4BSF8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1394917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSF8"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015641255" evidence="2">
        <location>
            <begin position="28"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="466" mass="51853" checksum="719B190CCD29E2EE" modified="2018-07-18" version="1">MLTRASTAGVLSQFLLASASSLSPVDTFYPDELNDTSYITNSALGTYGGTYRAPANKASQGSPYGIYDYCSMPHPRVSEYEMPEDRHAKLVYLEYMQRHQRRTMYNLAPGGENQPFDCSSFEAFSYGSQAHGPNGLQVYASVYTDPNNPFVDALPYVNSTCFFPQLTTGGLLDGVLHGKDLWALYGEKLGLIPKAPTDKVWLRSSSATLTQQSAGGVLRGLWPHYSGALPLHQQPGPDTINGGYPCNAKGAILSSIQSTSEWNQHLIVTAELRQSLGDILGATSSAWQNTFDHFSDNFQARLCNGYKLPCSFTDASKCVSESQAEEVFRAGDWEWNYYWRNNPQVVKYIQATEGLFIGEVVRRLQAVLNNKQKYVYSHTFFHDGDIGPFLGALGINQLRWPAMGSNVAIEVWETTAKQKKAYYARVLYSGHMLRSIHGILDWIPLNQLIDILKVYVPEDIIALCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSZ6</accession>
    <name>A0A2T4BSZ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_156808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSZ6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="13858" checksum="515C717AAC523711" modified="2018-07-18" version="1">MPWFSAVDTSIKILKMAHEVASVGFLIFVPLASPQALRPLKLQQSFAGQHPGSLHALPPTSPVLGQPACVMPQRKSPGSPGRTSVDRGPLARVDACRDFSSPIEPLERLFRLEETPEPRIFWRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT37</accession>
    <name>A0A2T4BT37_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_22412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BT37"/>
    <dbReference type="OrthoDB" id="5382952at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1513" mass="164120" checksum="225C3043C4814282" modified="2018-07-18" version="1">MSPELSVLFSDLTITRTKHASFNIRLEQYGIPQGGIWVTGQAFRWLSTTTRRLKVVEWHPKVYPPDERKTDGTPGIGKARAVTTPRGQPSPSPIVSTPPFSLYHAANRPQGRPRPAFKIMGLGNKLIWLFTIPHANRVRVFLLQSVFRRWFTVGTECAETDEALSNARGREPAWWACQYVESALGIQLDRDITASPSTLQKEEPPEVSKPVGQSPVIYPELDRYRHHDRARSASSRPAVDVPYRLATHDLPPPTPGSLLFSANSSQVSAISGSPSTRFSASPGPGPYSRDTTPTSISSQSPGLIVPNRGFPVNKFRQHSPAFTRPPVTRRRTGSISNEMDSISVDPHGLAAVRESLTSSSSSSTVKGSVINAKKERRGGKSLAAPPPSPPPRKSSQKPFASEDEDELSPRQKRQPGSQPMAVSSPPRAGLPLRSYHSPSPQAMPPRRPSRDGTSDLKSQLFTPIPVIQSSLALRAANLERRDSEATIPRPSQATGLQSKKSASTSNLPTAEQPATSSKLAGRRKLSISGPVRASGTPSPTVKASSGSRFPFFGRKKAASESTPNDKDKKEKQKISRKGPAAGTGHEGYGRLGAIRRRSGVVAPPQVSNESLVSGDSFLADRINPVVIAGGAIVENRNASAELLRSDSNLSLTTDERPSIDSIANSTTSSVARGMSGPGLWPSAIPRGRNQMSSARRPSDSSDTGGAPMQSTLAYRRSVQRLKSCPDDPLQLPRPINTSGVITSPLTSFDTSILSDESSLFNLQQLPSQDFSNNHPAPKKLKKKPRSPRKWNFFSRSNNQPKSDKASQPVAVTVQPVEKKPVAFYAIMDSPEQGAAEPDLKEILREADAYARSPANVDVPEVQAEDAPAVNASHLQPQSSVLPEPLSPVQDTYPVMVEPSFSSMEGTPPAVTLSSGRPSRLAQVGRIPQVVSNRPARPSPRSFSRPFVANQQLSLHIPPTHGVGSNSRVPNFSKPSTPVRDAFGGDCSTTDAGTEFSFFSEPRSHVTPEKATAQEFLAFSPRKNSDCTASSTESCVSYNYAEATAIVPRPDDPPVDDEVWDEYNDLLGDDAVKERQSTTSSRGIPFHLENYHLKLAKEKALESPTLVTDGRKLSAISDAPTASTTFSADMTERIRKAFQPHPSPTVPSPVPEVAEQPVGGHSRKPSAAESMRHSITSVRKSTQSGSSTSSGEWTPLAQVNLRVGSMTVSKWLSFGQVLFSDIRHLLVKGIESPERPSVLVIDGLGNDDWSFYAAETYSTADFFNLSPRAPLPTDVQSSASRYPLSPPNHHQVQYLSQLDEFPFPAHTFNCVVYRFPAAAPESHYQNVLSEARRVLKPGGCLELSILDVDLNNMGNRGRRTIRQLKERIHEISPETNLASTADLIVRLLGKSGFSTIKAARVGVPVASAITSSDDNSQGSGTAENKKKRSSKNQPSLAEMMRDHSPNADEGITNMVSRVGRWWYSRCYESATGHSSGKKSIWNDKALLRECEELGTSLKLMVCCARAPEGLNNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT47</accession>
    <name>A0A2T4BT47_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1089671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT47"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="167" mass="18051" checksum="A92B65A674FE356B" modified="2018-07-18" version="1">MQVHSLMPGHACAAGHIPSLVHRHDCTEEEGFIRPCADRHRIDLGTKLEKIEQTKATSTPCLGRLLRLHDQLSFRNQASHLASEEGSRSKKQGHISRKDASDIPASDATLPPLMHRSSRQTELLHWATDGDAPFGATGGGGGGGEGHPFRSSASSPRARDMVFASYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTI5</accession>
    <name>A0A2T4BTI5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1472527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTI5"/>
    <dbReference type="STRING" id="983965.A0A2T4BTI5"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA damage response"/>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="CK2_alpha"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
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    </dbReference>
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        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="303" mass="35228" checksum="ED520F19F7E2AFCE" modified="2018-07-18" version="1">MLALSRGEGEGLKSDQYEIVCKIGSGKYADIFEAVRMSNLKKCIIRPAKEAGRPGIEQDIKILRSLSGGPNILELEDIVRDNEMGTPSLVFEYVENTDFRCLYPTFREEDARYYIKELLKALEFCHGRSIMHRNIRPHNVMIDLNRRKLRLFGWEHAEVYVPKSRYSVRVGQGWAKAPELLLDYEEYDCSLDMWNVGVILASIIFRKEPFFHGVSSFHLLQTIARVLGTKGLLNYVEKYDIETTPEDVDAIPYFEKRNWQSFFNEENEQFSCNEVVDLVDRLLQWDHKARLTAAEALNHPYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTU3</accession>
    <name>A0A2T4BTU3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide lyase family 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1362784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="77013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015681659" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase 2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="250" mass="26144" checksum="797B2894B0DBEA3C" modified="2018-07-18" version="1">MAPKSIISLLCPIPLTAVLALDSSCAPGGNFDLSAWSLQLPTGSAGKVDTIESKDLQGCNGYNGPTFFTDQSNGELILTAPGNPDITGCATTSGSEHCRTELREVSPTTGQNTDWAPTGTNTLTVTMKVVQADDGSHGTAIGQVFAAAASKPLAEMYYSQKGDVTVGVKQDPSGGQAVTKLGSVPLGEYFTYVMSYSDEVLSISINGKETKLDTFSWGTPNCYFKSGNYNQGKTAVTSEVHIQSIAVVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU76</accession>
    <name>A0A2T4BU76_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1441717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU76"/>
    <dbReference type="STRING" id="983965.A0A2T4BU76"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="150"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="284"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="375"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="650" mass="69605" checksum="691202BCE43AC096" modified="2018-07-18" version="1">MQDLNGSAGQGAPNGANGARFGHASKPSNSDTGFSHGAQDQVQDAQLAPLQPRCSHRHRTVYLGNIPPDTSAEEILGHVRSGQIESVRLLPDKNCAFISFLDASSATHFHSDAILKKLCIKGQDIKVGWGKPSQVPTSVALAVQQSGASRNVYLGNLPEEITDEELREDLGKFGPIDTIKIVREKGIAFIHYLSIANAIKAVTQLPQEAKWQAPRRVYYGKDRCAYVSKTQQQNAAQYLGIAPGYAHMLTGADRDLISNALAQQSVAAAAVATSAGGMNNLGNRTIYLGNIHPETTIEEICNVVRGGLLHHIRYIPDKHICFVTFIDPTAAASFYALSNLQGLMIHNRRLKIGWGKHSGALPPAIALAVSGGASRNVYIGNLDETWTEERLRQDFAEYGEIELVNALREKSCAFVNFTNIANAIKAIEAIRGREEYKKFKVNFGKDRCGNAPRQVQQNSSPRGDGVSSPAPNGSQNSNSPSNGNTPQPAAAMFNASSNPLTMYLNHIQQQAQQQQQQQQHMSVQQNILFNTAQSNDMSMDVPQQGPIGGHGQSASISNGYPMNGSMSSATTIGGLLAPGSGRGQHSRAVSLPVLAPGFENGGISPSESNGSHGERRGHHYQASFGGMGASGYGLAIQGGLNGWVEEEVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUA3</accession>
    <name>A0A2T4BUA3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1441745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUA3"/>
    <dbReference type="STRING" id="983965.A0A2T4BUA3"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="2">
        <location>
            <begin position="267"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="717" mass="81636" checksum="EFB231FAF72B23CE" modified="2018-07-18" version="1">MGLHEEPPAISRHNTSSSRGSIEVAQQAAEFTKQSEKLSHQALGNTSPAIAVQADFITPRDPVIVTSDGNRLPGVPLDEAYKLNVLREELQGHLDNGRTELDEHHQHGEASRMTSKLHDGARKVSKETQARRKASKGTLSQTMPPSHTNPLFPPLPLYGPPSWLRNIQCWFFRATSFVLSLDFLGVIVLGSLFTSIPSIFQSLFQPDRNKKRPFYEQEVQNAAIRRQKEVEWEQKRTNKHLDVESESIVDEYPPTEGGKDPIVCDVGYYARRVGLDVETFKVETEDGFIIELWHVYDPKEHTPLDEASREKLGPDVFQEPSEKPEKPGKKKKKFPVLLMHGLLQSSGAYCCNDDQSLAFWLCKSGYDVWLGNNRCGFHPEHVLLEYGDPRMWCWNIRQMGVFDLPALVSRVLLETGFAKIGLICHSQGTTQTLVALAKEQRPELGEKLTVFCALAPAAYAGPLIGKMYFKFMRIISPAMFRLMFGIHAFIPFMMQMHALLDPRVYGWLGYKVFSFLFGWTDERWDRGLRNRMFQFAPVYVSAESMRWWLGRECFATHKCILATREVLRAEEGLDGDGGDSSTSPDDDDSEASDDQAHAPKQRHHHIKGSTAWYNHQVPPFALWVCGDDHLVDGQRLLRRFKAGREPHVQVVHSKVIPEYQHLDVIWAMDAPDQVFREIREVLWKTCDARDICRTPEGCDAVERWEPAEVVTMEVGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUT0</accession>
    <name>A0A2T4BUT0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1404785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUT0"/>
    <dbReference type="STRING" id="983965.A0A2T4BUT0"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="288" mass="31556" checksum="649026EA690A2029" modified="2018-07-18" version="1">MAESKTSAISDEPINVLIALHPKFDIFDFAGPLSVFNAAQHDFSDESSKAFEVTLAGAEPQVLSSQGAIVQSQITYKEAHERINEFDILIILGGNTDEVIKKELEPLGIITAFSDLQKRDPARERTMLSVCTGAHLLAREGILCGLAATTHPDHLTRFENLCSDACTRLGTDRTDVIDDARYVVNNLRFELDEDASPYTRRKSDAGKPHGRKGSISFKESRTRRESIVRRVAMRLGGLRVITAGGQSAGVDASLYLVSALVDDKCAEEVARLLQWNWAKGIVVDGIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV22</accession>
    <name>A0A2T4BV22_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_141709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV22"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="654"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="907" mass="98176" checksum="AA9B32F0248573B9" modified="2018-07-18" version="1">MSSNAVKNGSSARLNQAPSNQSLLLEKVNARTSTPDSEALASSEDEGDHRHEASQSLAQPVKPVRRASWLNDTSAPLSRPRKGSFASNSMSPTTSHPSTPSIETGAGAWGSHPTSSVMGRGPGSNFPWGTGIWNNDRKDPPARLSEVLPSPTSTVPPGAGNNSFFGPDSGLTPTTSATREPGTNSQIPFPIPLHPTPKTYRSQSYSAGQLDPETSPGAGMSSSALLGRARYPTLQHRPSRPSMLSEMASDGTMLGKVKEVEDDDDEESSESLQGSFHQSAESKTIEMLARENAMLRQQQQQQQQQQQQQHQYGTRIRQRGAPGSYHGNGYPLREFVPEEDYAIDELDETNDGEAIARRATERRMSEFGTTGPYRNPMGYDGQKGVPTLKKALWSSSPSYFANDFSQSRRHSFANMPTRQGSISSIADSVATLEAPNPDNQLNQGYSMSYSDNAAFGGANNGKFQAAATERHRAVTDRSLTANFFPGGGNMAGSIPSAFGNPYMSQYGMHNQFANRPPSPHRNVYSVGQPRHNQLLHVVLFKCARADVFYIQEGTGLTVKPGDLVIVEADRGTDLGTVARDNVDWQTAKELKEHYAEEQYKWLMMYSQNAAAAQEGSGAGLLASSNGLQGSAIGGMGPPSQHHMQEPSAGELRPKLIKRLAQNHEIHSLRDKEGQEAKAKRVCMQKVKEHGLNMEILDAEFQMDWKKLTFYYFADSYINFNSLVTDLFKIYKTRIWMSAINPASFASPTLGIQAPSGVGPGAVGVGRGANANERRQNQTSQQEQQSQAFAGAAQQVRGMRSGYTQPPMAADRQGPPATGFPPSNYAYGTAGAFGNARMNGGYTLGINQGVDPFAGTGFPQSGDLQSIRQRFPTSQTMPSPGPHSQGVTAMSPHNDWTASFQGLSLNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVB6</accession>
    <name>A0A2T4BVB6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1076469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVB6"/>
    <dbReference type="STRING" id="983965.A0A2T4BVB6"/>
    <dbReference type="OrthoDB" id="5154093at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="18326" checksum="CF7D9CC6B9DD21B9" modified="2018-07-18" version="1">MKFGKQIQKRQLEVPEYAASFVNYKALKKLLRPLLHKMTATARPLLRTRRRRSSSHDRASRGARPSSPRSKRASSSSLPISTSSSSSSRSMVRPFQRFLRSGTRHPSPRQRSCTSREPSRSNRSSMRPSSASCRIRPPPAFRNSVPGQMESRSTSTRRLPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVC9</accession>
    <name>A0A2T4BVC9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1447949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVC9"/>
    <dbReference type="OrthoDB" id="5152716at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="18230" checksum="5F80778B96FB0305" modified="2018-07-18" version="1">MLTIAPGHLLRSIFSTLILSACKPLLKLFTARLDMDGTSKEPRSTTSTREAELNPELILKNLFFTIRASPKSNEKIEKRTRLSDVHRHPPYQHARRQEPAGSRSSRIKQLSIQQRATRLSAAILADRARGPEVFTLGYRGYAIINQGGFDGSFGNQSERRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVF0</accession>
    <name>A0A2T4BVF0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidylyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1313415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVF0"/>
    <dbReference type="STRING" id="983965.A0A2T4BVF0"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29382" checksum="943702B07B21B9E4" modified="2018-07-18" version="1" fragment="single">MRPNPKQLVDFFARSLTSFQSSPDAFRILCTLPHVVGREPGPRRPASRVKRLVVLDSSFNPPTRAHAEMAVSALKWASSSTTTSTTPLRGGNDDDDGAVRLMLLLSVNNADKAPKPASFPVRLGMMDGFGHEILRSVDLEGVEIDVAVTKMPYFHDKARVIGESGVYNSSASEEEEGGRRSEPEQVFLAGFDTVIRILNPKYYGKEEGGMKAALGPFFERARLRVTMRPDDEWGGEDEQRAYVRGLGEGALDEVGGDGAWAGRVDLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVH5</accession>
    <name>A0A2T4BVH5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1464802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVH5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVH5"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="8">
        <location>
            <begin position="133"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="9">
        <location>
            <begin position="659"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="788" mass="87154" checksum="C8D8FEF5DB70AD1E" modified="2018-07-18" version="1">MASRQAAEKGLPLELESEPFLVRDEARGSRILDRPHRGLRYYVKWLLTFIVFLFACHSAVVSTFRWTTVSGEIYNSEVQREIQEELAGRRLAALLRQQSQEEHHHQEQNHSRLGKGGKAQAHGTAGSAGDGHYLIGVGKADITGPVVEINMMGYANTDQVGSGVRQRLYSRAFIVGDLNQPEDRFIYLVLDTQAGDTAVRYGILRGLAELGPEYAMYGHDNLAVTATHSHSGPGAWLNYLLPQITSKGFDKQSFQAIVDGCLLSIRRAHESLEPGFLTAGNTKVYGANINRSLYAYLANPAEERAKYNISAEDDGSVEKDLSLLKFTRASDGKNIGVLTWFPTHGTSMLANNTLITGDNKGVAADLFEKRVRDRDGETDDFVAGFSQASMGDASPNTLGGWCDDGSGERCDLKTSSCSSSGMTKYCHARGPFFREKDSGASSCYEIGKRQYEAAVALYASMEQQPPNIKGSGVKAFHRFHDMSDFQFQLRNGSAAPGTWDEPGHFDITQWGSDESNSSPFWKALRWLVGAPSKEQVQCQAPKPILLNVGKTHKPYHWTPDIVDIQTFRVGQFIIIVSPGEATTMAGRRWKDAVVESSRTQLAKELDGREPIVVLGGPSNTYTHYITTEEEYSIQRYEGASTLYGPHTLAAYIDRTDALLHLLKDDAPRSEPGSRESGPLPPDNSDRSFGFNTGVLFDKPLKGRQFGDVVTDIPKSHFSPGERVTATFVGANPRNNLRLEQTFAAVEHRRPGETEWTMVRDDSDWGLIYSWKRSSLLMGTSSVQRHMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVL5</accession>
    <name>A0A2T4BVL5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1404365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVL5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVL5"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="393"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="616" mass="66080" checksum="4E89575B29A6A4E9" modified="2018-07-18" version="1">MQSREDPRYGSTPDSTADYDLSRPIHPAVGMRQGLPNYGDPHFSLFLRKVFIKALGYSEDALSRPIIGIINTYSGFNPCHGNVPQLIEAAKRGVQLNGGLAIEFPTISIHESFSSPTSMFLRNLMSMDTEEMIKAQPVDACIVIGGCDKTVPAQLMGGISANRPILPLITGPMMPGSFRGGRIGACTDCRNNWAAFRANELEIEDISALNEELAPTVGTCGVMGTASTIACLTAALGLIPLRGGATAPAVSSARLRIAEQTGANAIAAAKHKRTPQSILSEASFHNAITVLQAIGGSTNGIVHLLAIANRHPEVYGRITLQTIDEIGRKTPLIVDLKPSGDNYMTDLHNAGGMPALFNVLRPLLKLDALTIMGKTLGEALDEENFRPFPLTSQIIRPLDNPLYPSSSLAVLYGNIAPDGAVIKASASKYRHLLNHRGRAVVFAGPEDLAKRIDDPDLDVDEDSVLILQGIGPIGFSSPGMPEAGLIPIPRKLAARGVKDMLRLSDGRMSGTAGGSIVLHISPEAALPESVFAVVRGGDVVCCDVERRKLEVELDETEIRRRVAERRDRLESRLEGRGPGESRRRPARGYRGLYETSVMQAQDGVDFDFLTANGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVM4</accession>
    <name>A0A2T4BVM4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1339450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVM4"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58457" checksum="85ADCB2032FA3D65" modified="2018-07-18" version="1">MGLGNLSLLATVIAASVTYYWVLRRLTRANVQPDRTKRPDTSPNVRTTFRVSGVPIDWGPEQLRSFLSSKTSTTDVVVESLAHEAGVDLQTATVSLGTIPLQLQSGRTWQIQLPQELEGQVCGEQCLAIETDFHGITTLYAPPPEDHRIDIVALSGLGHHAFGAFTDRKGTHMWLRDSLPWHLTSETSGKPMARVMIYGYESAIAGSKNMQNIEDLATTFHSSLYSLAADPTKRRIILIGHSFGGLIIKQTLISLSRSKNPDDVKILRAVCGVIFIGTPHDGMDISSLVPMVRDGANRSLIESISRLNSQVLSIQQRDFHRALGDEGDLEVFCFYETVESPRAQQDEDGKWTMTGPPAAFLVTKSSATYCRPWNDGPEYSCAIARSHSDLVRFGPHDADYRTMKERIKGIARRALEAQRTLQAAAPKVPAAVNIGLDKNGDSTEEDVANASLVHNSTQYKCHGERNTTDGLVQAANTRAREVDEKHVNTLAYLNNRELAFVDEGRWKEAENLWSQLAEKRKQILPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWG0</accession>
    <name>A0A2T4BWG0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1424927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWG0"/>
    <dbReference type="STRING" id="983965.A0A2T4BWG0"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="192" mass="22058" checksum="060E2DEC7647BA4B" modified="2018-07-18" version="1">MAASKASRIGEEIWKTRIDKVNAELVTLTYGTIVAQLCKDFEDDYPEVNRQLDKMGYNIGLRLIEDYLAKSNTMKRCSHFRETADMISRVGFKIFLNITPQVTNWTADNNSFSLVFDENPFADFVELPDDGRAQNELWYSNILCGVLRGALEMVQMQVEAHFISDVLRGNDTTEMRVTLIRYIDDELPPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWH7</accession>
    <name>A0A2T4BWH7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TOM core complex subunit Tom6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1339528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWH7"/>
    <dbReference type="OrthoDB" id="5403997at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8165" checksum="A0C1E85CD37F2C7E" modified="2018-07-18" version="1">MPPKRIYGEKGGRRAPKGFVASTYDTLTNAENAAFVRSIAIFGAAVTFLSSSWGEILLPPYVSPDDPDLQQTGICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWV3</accession>
    <name>A0A2T4BWV3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair protein Rad26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1360596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWV3"/>
    <dbReference type="STRING" id="983965.A0A2T4BWV3"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048379">
        <property type="entry name" value="Rad26-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022093">
        <property type="entry name" value="Rad26-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048380">
        <property type="entry name" value="Rad26-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21046">
        <property type="entry name" value="Rad26-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12331">
        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21048">
        <property type="entry name" value="Rad26-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26-like N-terminal" evidence="5">
        <location>
            <begin position="362"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like helical repeats" evidence="3">
        <location>
            <begin position="468"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like C-terminal" evidence="4">
        <location>
            <begin position="712"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="85413" checksum="E52D0A3E78794A89" modified="2018-07-18" version="1">MDLDEFSDDGFDDLTDNVLQELENQALQSTQAQHARHAVTQQFDYAWEQEDDDLDTTEVINDGGVAVGRPIVDKTLRQQQQQQHQQHQHKQSQRGRPPIPAVPNPRWNPAIDAAAMAERPRMANVRSLNQPFMSSQRFPDPSQSAARPQTAQMAALPPPTQGQSGAMVTALQKRIRALEAELNAARGEASILRSNSTKAQQSYDEQLSRLRKLNAEQLQNKERAMEAALAAEKHANVELQFLQRDMREANDRARKKDTVAAGLATPKKASKTFGFADGFDDMDIAASPSKGQGRNKSAGSVAANIGERTPSKGKRKRPVSESPMKALDIHTGDVEMMDTKPISQPVLQQPVIVAAPTAPFDFLQLVLDHGFAQGQPPTFDILSRISFPSDPSVSFATLIFERLPLMGNPYQPMQLLVDFAEQIIILWTRCFEERFWEPIKYLVALISFTFQLNTSSVAPLIIPRLVPVAQTTIFTVAEGLSRLSDGTAANNDEQAILEQHIDTTHMLSLLYTASLACATVPTEVEDGARYTSPAFWKLISLDFTLLLLMPKQKLADTIGMLDLLATSSLPDSIGPISDEKDAESVARAVIERVSAKLMEHPRATTTPAQKRALRLAALRTLVTFARHEFGAKQLASHDNAIPRLVACLSTSIDELYDQPIPPSILPPFPDVMTSSSLKFVEPTTSADLYRIISQCVTLIHTLATDPATANLADITRKLSLSHGGSQRYLIALGRLSFAEEDLVMEAGIEGEVVEAAHELLEMAVTPDEGEIVSEAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXI8</accession>
    <name>A0A2T4BXI8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1361160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXI8"/>
    <dbReference type="STRING" id="983965.A0A2T4BXI8"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13164" checksum="ECC96FD11C8058ED" modified="2018-07-18" version="1" fragment="single">MVFFFFVCGEHTFRSEVKGYEGVICQCHNCGNMSARVIKSRPFFTFCFVPIIPFTISGFVEVACHICNFKQPLKNRPDVVSMANGGNPGAGPLPPPANPGWGHQQQQQPYQGQPPARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYH5</accession>
    <name>A0A2T4BYH5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0220-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1337699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYH5"/>
    <dbReference type="STRING" id="983965.A0A2T4BYH5"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="18688" checksum="6D335328C316BA90" modified="2018-07-18" version="1">MEEERLWKFRKPEWLNSIWARNAGVYGAGALFSLAFYVMLDSAVWSKSAKNGSNVHVKFVDWLPLIFSSLGMLIINSVEKQRLSADSFSYSGSGVAWKARVVLFLGFAALAGGMAGGVTVFVLKFVVPGVGMPALSMGIENLVSNALVGFSSVVLWISQNMEDEYSYNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ68</accession>
    <name>A0A2T4BZ68_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1403119</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ68"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ68"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="64"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="255"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB74622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="404" mass="44777" checksum="242CE873ABD1A88E" modified="2018-07-18" version="1">MASRAFSKTLRAPAARQLIAPRVAQRSYMVARGATRAVAAARPALAGVSQQQARGIKTVDFAGVKEEVHERADWPQEKLLEYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKNGKSWNDAIQDGWVPGKNLFDVDEAISRGTIVMNLLSDAAQSETWPSIKPQLTEGKTLYFSHGFSPVFKDLTKVDVPKNIDVILCAPKGSGRTVRSLFREGRGINSSFAVYQDVTGKAEEKAVALGVAIGSGYLYKTTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGANGMDWMFEACSTTARRGAIDWTPKFKDALKPVFNSLYDSVKDGSETKRSLEYNSQPDYRQKYEAELEEIRNLEIWRAGKAVRSLRPENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ77</accession>
    <name>A0A2T4BZ77_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1358912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ77"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ77"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="378" mass="42540" checksum="8D4279A049E404D8" modified="2018-07-18" version="1" fragment="single">MSRPSGTSAVSVRHASNNSSSAFVSAPLPPADQDEICPVCKTTRYFNKDMEFRVNTECYHRMCKTCVERIFKDGPNQCPYAECHKTLRLRGFKTAFFGDLGVEREVDIRRRVAAVFNKAEDDFESLDAYNDYLYMVECLTDDLVNGGDEARKKAEAQLAEWEAQHKAEIERNRKLARESDETRQKRLAAEQDAARQRRLQELQEDAAERANAARFREEMLNSLQNAELGRAEEAVDRILLKKRGQQKRDATLDAVATMGGSGLSIRGLRDKRAPVQDDRPYDPFGGLDLAPQRIDLSSEKLSQYKSEWLDITRTKEDYIVGGYSSREYLTRALFEAFSGLGVFVSEDKDMRQEATVAASLEAVSAGPAGGKMDLDGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZL6</accession>
    <name>A0A2T4BZL6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1380314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZL6"/>
    <dbReference type="STRING" id="983965.A0A2T4BZL6"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="464"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="819"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="908" mass="99051" checksum="6CC4A2790B1A4F97" modified="2018-07-18" version="1">MDVNGGNMAGGPRRRPPQYMTGYQQHQHQSHHQHAHQYQSHHPQQYQHQHMNSMYSPYGSYAPQSYYNMPPPQFQAGVHPGYMPYQSYTRSPPPVQQFAPMTGVAVSPGYHRASPIPTVPYQAPLAYGPNGLPHTPSSTHSSLPLRPPTPMTPQTPRSDQSTGVVPPPVMNYVPPPMAVPVPAPEVAPVLASEITPVLASAVAPIPALVAAEVTAVVATEDVTLVVESSEPFRPPLPWLSHPDVPFPKRTPRSKRQNKLTLAEGGSISLPVIAAEQKSTEEPAISAKPEASTEAQQQDGKEAGSAPDSADISKASDEKKAHVARTAAPAVPAVPVLPKHSPKPSASVTPAAEEQQGMNGDAAKSDNQDSAVADTAEPQPDDKNDAPSPVVRAPPTSWANLFAKPSARAAVHGSATGGDAVNGEAADGSNNFASGFAKSNIHSLAQAIQSYQVENIGKVDFLEPRGLINTGNMCYMNSVLQVLVSCVPFYDFLDQVGKKAAHSFKSETPLVDALIMFMREFKVLKSAPSVEQLNRILKSEDLERYGEPFTPEFVYDAIRHLPRFASMRRGHQQDAEEFLGFLLQSLDDECTHVMRDLPLGNEEVPSSNASTGSGVASDDWLEVGRKQRAAVSRLSGHNTSTPITKIFGGLLRSEFRVPGLKDSITTERYQPLQLDIGSPDVHSVVDALRGLTRPERLQGDFNSPRGKDVMATKQVFIESLPPVLILHLKRFQFDAEGRGTVKIWKKIGYPLELEIPREALSRQRRQNLDNASMPRYRLISVVYHHGKNASGGHYTVDVRRQDGREWIRLDDTVIRRIRPEDVAESGTEEDAKDARKDATTNASSNRFGAMNDDDTGDEDGWKQVTAPTSGGKKWSSVVNGATNGAVRDKQVKDSIKDNKVAYILFYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZQ5</accession>
    <name>A0A2T4BZQ5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1380168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZQ5"/>
    <dbReference type="OrthoDB" id="4892440at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015449667" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12528" checksum="E5E733F7F91F243B" modified="2018-07-18" version="1">MQFSVIVAAALAGVAAALPPRQFHDTSKAQVAYTYTNGTYTRPHFIKVNQGAQKLPSGGPVTDVFVSPPFDGRHYVLTECSFQTPTNKSLGAVSVRKAMTVPVNPPAAVAYVTCTTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZT7</accession>
    <name>A0A2T4BZT7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RasGAP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1440229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BZT7"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="596"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="798"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1286" mass="142932" checksum="40991767ED72C9FF" modified="2018-07-18" version="1">MYLRVTNDADTDPAANSPPVSSTRRASPGQSLRSCPVSTLLGPPEPSSTCTCTSTGLRNDDGNGDNDVSANSSSSSIVESSTPCSNTTTATRTTGVTASGKSSSSSGGGGGDVRCGTGVRMVLNNGMSKSPPVMDGYATRLQEGGSSDSEDQALLQRQQQRQGQDQSLAQSRHPPQGQMQQRHQHQRQRLQAPLEFHRINLERLSASNLRSSFRFRHRVSSISSGSQPAVDDHKTLKPSSDPASYSTIPTVRIPEISAPTSKDKNKSSHHNKRLLKRQPSRPTSPLVEPQPSVDSFPYPIPTEDANRLISLMKALGGRMRGELEYQGEYQGTWHTGMAYIDEEKGTLMFGLGHTGQNASFHIPLVSDLRGCKVHVTGYPDAERECLEVVPNQMGLELLIRPIISEELELWLAALLCWQQLTPLNLKPPSGKPSSPSGHIRPEMRRRAKSSDAARATNIIKVGKFMLWDKGPARSARALVQRSSTRDLMHPAMFWRRISCVLQDNGEFRLLMENDVSVLSSIELSQLSRCAIQGLDRSVLGEEYCIAIFPIYASTATHVTIFRPIYLAVDSRIDFEVWFALLRTFAVPDIFCLDDPQSDEIQDVADIEKDQPGEVFRMEKIVRVRVVEAKIKANPSGPEWFSPERYGRAGPDPLVGCYLAEVILDGEVRARTTTKMDTKNPFWREDCEFNDLPPIIQDLSVVLKRVESGPEGYSKPPTSQEIICGSVKIALNDLERGQGQEQWWPILDERQQNIGSMLIKVFHDEHVALLSKEYEPLSEVLHRFPTGLTTLISASLPGQLRILSELFLNIFQASGSASDWLMALVEDEIDGIGNQAAIKKYRFSNRLKSSESLESSNEREMMVRDIHKTLAGEANLLFRGNSLLTQSLEFHMRRLGKEYLEEILQDKLCEINELNPDCEVDPSKLAHTGAGADLDHHWGRLIHLTTEIWLCIADSAERIPAELRHILKYIRAVADDRYSDFLRTVSYTSISGFLFLRFICPAILSPKLFGLLRDHPKPQAQRTLTLIAKALQKLSNLSTFGKREEYMEPMNRFLTQQRQSFRGFIDHVCSIPADRTGRALPPSYITPVTILNRLGPTAREGFPSLPYLIDQARSYASLVKLWVDARPIDAKHMQADGELLVFNDLCFGLQKRADACLAKVMDFRSREVPSYMSADQLAEILEQVNFTGPYHPYYPGSPSSMPSGYERPPGSSSSDGGGETKQNRRSKEWKRGREDSDPRKGNSPRTASGSASGTAKQKNGKMGRTLLSGIMKIGGVRADSPESKGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C022</accession>
    <name>A0A2T4C022_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C022"/>
    <dbReference type="STRING" id="983965.A0A2T4C022"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="67"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="552" mass="60472" checksum="80D4FAD1E646761B" modified="2018-07-18" version="1">MGELHGSRGFSVLINGKVYQSPESKSADVGPCFAECMIIRDGIIQYVGPEKDAEVEAAKAAGATIKDLDNHTVLPGFIDGHLHILLLGQSLTKVGLEACKNLEDIRSEIKRYAAAHPEVPRIFCRGWMHSMTPEGVDSTLLDDLDKRPIFVDTKDLHSTWCNTTGLEEVRRVMNIAEDAPDPAGGTFQRGEDGKLNGVFNESAVFEYIWPFTAKVASIKERKEAIKAAIKAFNAAGYTGMVDMAMDETIWEPLVALRNEEGLGGMRIAAYWLMKPSDSLEDVIPQVDRAIELAGQYNSRTTPDCRVVGIKVICDGIIDACTASLTEPYSTGTSPDPIWSEQFLNPIVSKAHAAGLQVALHAIGNRTIRMAIDVLEKNTDRSRRPRIEHLEVSDAEDAARLGKLGITASIQPVHSDPAILRAWPRLIGDHRCKRAFAYREFADGGAPLALGSDAPTAPHLPIPNMYVATTRRSYREPGLETVVNPEFALTVCQSVVAATHGSAYSVFADEWTGSLRKGLKADFVICDVELEAERLIRGVVKETWFEGTQVYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C030</accession>
    <name>A0A2T4C030_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1380478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C030"/>
    <dbReference type="STRING" id="983965.A0A2T4C030"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF0">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="339" mass="36739" checksum="5ABB52E05FC5B8B0" modified="2018-07-18" version="1">MVKDNEYTTKGLPPPPPISITTKPMAGLLVDIYGLEELPPAPAPVSCLWLLHPRTRARGIMHDVARRTIHAWNQSQPQNPARGLVALVFDMPNHGTRTVSELANKAWDQGNEQHAMDMLGFVRAAAADVSLLMDQVAGYLGREEVDGHVCLGWSLGGHAAWESWFAEERVDAAVVVVGCPDLAGLLSSRAAASKLDCGETGFLGSKYFPADTIAAIRKSDPKGILFGTDPVPSLPLPQAEQDRLRKIFDGRIRGKKLLLCSGAADELVPYKHAQPLIGVLKDAAEGWYRDGGLEVDDRVYEGVGHKFSAEMVGDAVEFLVRVFGEGRRGRDGGEARAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Z8</accession>
    <name>A0A2T4C0Z8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUC189-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1402780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Z8"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Z8"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="164"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="404" mass="43859" checksum="3F2AAD1A6946B0A7" modified="2018-07-18" version="1">MSTPKRRTPAKLATPVVKPDARRTARNTIDESRTTVAGADALRSSQAETIEISSDPDSDEDMSDVEDVNGAADEAEQNPEQKPLANGQPKQSGKDDEAESDAEETSPSFGELLRGSEAIDVTAMLQQSSADSSNAAAQASRSAIAPPSHQSLTTVLTQALKTDDTDLLESCLHTTDIHTIRNTIERIDSSLAGILLNKVAARLHRRPGRAGTLMTWVQWTLVAHGGALAAQPKLLHDLNSLQKVLAERAKGLNSLLALKGKLDLLEGQMELRRRMQRSAGLLGEGDEDADEEDVIYVEGEERDAEQKNLANGVRSRRRGEAGADDNEDDNDDRVLNGFIGDSEDEEEGSEQDEEESDAEEDQLDEDEVDFDDVDESMGEDEESDVEVAPPTKMQKVSKTSGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C102</accession>
    <name>A0A2T4C102_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1379296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C102"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="551" mass="58318" checksum="781E8522CCC8B193" modified="2018-07-18" version="1">MDPEKEAIPSSSSDEDPPSTPPTPPTPPNHEPAARTVRGLRWVLVCAALYIGTFIYGLDTTIAADVQGAVVEAFGHVEQLAWIGAGFPLGSVSVILLYGVLYASFDMKWVFAASMVLFEVGSAVCGAAPTMTALIVGRVIAGSGGSGVFMGCLNYFTALTTARERGIYITGTGFCWGIGAVLGPVVGGSFVQSSATWRWAFYINLIVGGAFAPVYLFGLPSVHPMTGVSVLERVKKIDFLGLLLGVGTWVSFTMAFTMAGGQWPWHDGRTIGTIVAFAVVVACFALQQTFCLLTTPERRSFPVHLLRSRSQVLLYVATSSNITALFVVVYFIPIYFQFVHGDSAIEAAVRLLPFVVLTVSFNLAAGHLLSRLRYYMPIFAVAGFFITLGSALLTAYLDPDTPTAYIYGFTVLTAVGTGLTLQIGYAVATLKVPAHQMGDALALQNVSQIGGTVIALVIAGQVFQSEATKNLTAALAQTDFTAADIQSAIAGAQSRIFEEITGDLRASAVLAITKAMQKAFILVCVGGGVHTVSALLMKREKLFGEVVIGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C114</accession>
    <name>A0A2T4C114_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1336292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C114"/>
    <dbReference type="OrthoDB" id="4776075at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="81" mass="9034" checksum="19A875C02578F679" modified="2018-07-18" version="1" fragment="single">KTYNSRCSLVVTHPTTNLPVSGLSMGERTGPRVFHYLWSYVIGKAAYSVYIDGLDRGNALYFGVCKRLSADCFLFFSSPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C156</accession>
    <name>A0A2T4C156_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1336138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C156"/>
    <dbReference type="STRING" id="983965.A0A2T4C156"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="22681" checksum="BC60E70BEE6377A0" modified="2018-07-18" version="1">MPGTSPVVLILGAGPRVGLPTARAFAAKGYKVAVVARSLNEADSTDSQLNIKSDFANPDDVVNAFTKVKKNLGIPSVVIYNAGAATFSSPGDPFAIPLDAFKRDMAVNNTSVFVAAQQAVLGFKELPADAPRVFAFTGNILNVRPLPQFLESGAGKFYYVDERKADGSAAFKIDGEAHAKLFWELAEAKTQGPWLQTFVKGVGYKDFGPYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1R1</accession>
    <name>A0A2T4C1R1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1255916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1R1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="26175" checksum="51733BC0FFBC0B66" modified="2018-07-18" version="1">MSSSSMQKPRQRAPTSGKYQHQIDRWSAPPLMLRVTMAPVLQLPCSSSSSKHASKPLGPETLERAATQGVRGPLRPTDKTRRGARVVYKGSLHHYGRYYRLLLLGFESRWTARAARTADWCCRRKLDGFCSAPGQAEVASFTRHDHVSSASGSRTNTVRHEPAANDESSGQVALYSLLLCAASMVNGSMAEYYDGEGSLLPPGKPAAISQMEARETEDANPHFTPRLSMGVLCKRNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2T7</accession>
    <name>A0A2T4C2T7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2T7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="65" mass="6493" checksum="7AA0690D08DAC26D" modified="2018-07-18" version="1">MPPFGSSTACRPLAASALTAPPKSRTPEPGARAASSHLYGSSSLTPQPPSFEAGHRGASAAFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2T9</accession>
    <name>A0A2T4C2T9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide exchange factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1335002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C2T9"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="396"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1578"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="946"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1272"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1352"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1519"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1275"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1294"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1355"/>
            <end position="1369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1825" mass="200476" checksum="4909036018AA6417" modified="2018-07-18" version="1">MDAAEPPLAAARSTVALRPKLSTKRRKALQLKAIQTSNLGAGANYDNPTRKVSGGSVSDAKDTTPPKLSTKVKRKPSTTTGRPIVPVTEQRSINRTLSIGRRDVEKDRWDVAPDGASAGREGRQFSVVNVGNNGKLFLRPSVRRGNKRYPQPNFTFPITPPGTAGLEGAYPENRDEPEALKPPTNLHDNQFTPTPRTSTIPVNYISDPSALPSSSQHRRAVSDSTVRDFNSPTATDTEGYRIVITKPTNGDHHRPKTTDHLDGPDADGVPLLNINIPSWKLGTPRFSTRGTPIFRGSSYAPTEEMRSNSRASLHHSSERNPGGPLRGLGSRRPNHLVIPQLRFPRTSLASSQASSARPRRAVPSAYATHLVIEPEMFDDLTFKPACDDRLIVRYSPSGSVTAATPSRLVAEITSPSFLDYELISDFFLTFRAFLEPEVLLRMLMARLRWALERTDEIGMIVRVRTFVAMRHWILNYFVDDFVLDYDLRVLFCILLNDFVDELSQDAKERRVQLKILTELKKCWRRVCAHYWDSPDFDDALAAQAPVAPGGIAGHRDPSLDPTFWDREGIDPPQWHAVSAMPNGVSDEANPSSDVLPTSTNIGHFTLSEDRPGTPEHQMIANTTMLGNGPASPLSIASMDIVSCSFPSKNVRSLNPNSSQPLAAHPVYSTSPVLPHGAIATTPKALAGKRVRPAHSHSRNNSATDSLRGTSFDHSPSQDVDLHMILQSAGNLVRGNILPPGQPFVDIEADTPTGDHRQTTVFQPVSRHGTKDRIFGVAMTGSGMKKFLGGVRRALNTRGQWSSGSHTSLPAVASLASHTFSIDQLPGTAFTARGCTTQSTTRPLVRIDVLGAEVAEDFQRAIREEEEAAEAERLGLPKPSPKPPRTAPRPMEYSAAHMDSTTAEHEPEQQRSRPLSDMGITAGSQSIVIVDDTAALDRSNMRDRLPTTAFDPASVGGLSAGSFLTPGGDPTPPTTPPAQLMAGTPRKSSSLFHQLAAPPLAPQDEPLPTFVSNLGADQYNVGSSDDAGRSSFLTLRRGSQRHPVPNRGTLRIDQRHQSTYTRQSIYSFGRPASFNSRLERHSTARSFDATTTSSMLDEEYGTPAVEPLRMLRRRPGGYLRDAAKVGSLSNQHTLRKSRSVASFTTYTESIRSSHLLGAQAEQDDDDRSYAGVVEDQLPRDRHKVFSVGQLTGKPAKRHLSLISTHSSKPIMRPSFEIEARKLAQIPDEDDGGIESALLKLEGRYRPKTKSLDLFRQTAMIDADEFGISHDAAYSRSKGTQSQGSEKGSVVDDNRNQQSRDLSQNRGKQPVSSAYSRDTMVVRTEITNVETRSFLTADSDESYCSIPLLERGLSNDSLDRRGTSEWTDRSVLRGSSDEDDAAASDAALEGRDVSHQVSDSQLSYAFVEKTESIENITAGQATPPAVDAQSFLEDASVGGSDLSSELTPSENEGVYKPSGRGAAFSISSQPHPFGDPLDAVRSNSSSARMTLAQALAMSPVMRSQLTMSPVMTNLERTLDPDQIWSQKPPPLSREIFHGTSPKADYEPPRTTEAPVQAAPEEETPKTLKYSVHLPFILAFPSDILAQQFTLIEKDALNDIDWRELIEMNWRNATSNDSRSWVDFLRNTNAHGVEVVVARFNIVVKWAISEIVLTQHVEERARCITKLIHIAAHCRRYRNFATLAQLTIALSSAEVSRLHKTWDLVPARDLNTLGELEALVTPTRNFYNLRAEMEVGSDGGCIPFVGIYTHDLLFNAQRASEIASSPNTPPLINFERCRIAASVIKTLLRLLEASTRYTFQPVEGITERCLWMGALSDDEIRRHSEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Y1</accession>
    <name>A0A2T4C2Y1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_332543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Y1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="108" mass="12640" checksum="38466EAD4BE64E56" modified="2018-07-18" version="1">MDRLVAVRRRLLLDGEHHHICRELPECMHVLKQEASADGAKERGQAAGGGHARKRERVRLSTETHQKGQEIRRWGGSGDKVKHHQTRKEKEREKGQQKGKLRRRTRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C326</accession>
    <name>A0A2T4C326_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C326"/>
    <dbReference type="OrthoDB" id="4923568at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="16322" checksum="EA15BDE7B234D7F3" modified="2018-07-18" version="1">MSRERLAMTALAGVGVVGATIYATRRGGPKTDAQDRRDKAQETRELGLGSAGVGGNRMAGGPSNSAAPSGPERDPNDRQVTTADSRDKLPSGGVGGGEAGSGSDHKKWPNPANLLGSAAQKTGSNAASRSDAEGYHDTRGISKMGPEVETKRGPADATRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3H9</accession>
    <name>A0A2T4C3H9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1401561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3H9"/>
    <dbReference type="STRING" id="983965.A0A2T4C3H9"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="566" mass="61480" checksum="C5C0E707EFCFF552" modified="2018-07-18" version="1">MSAPSPGGDATAAPPAPAKPRLKINVSRSASFVGDGAPTPGGGAPPSATAPLPTPGEGARKVKLKISSSQPPTPAVPSANNDSAIKDVTKDQEKEREKEKEKEKEKDKDKNKGLPPVVTTKAGRQAKPSQKLIESKKRSLSDDEDEAPLRGSTAGTAGHGPPPATKIKIKPIVKVGGAGGGTKVKSGSKAGLTQLVLKPRGRPPVHPPGDGYDSEASDNEIDPAIEEQFILRMLPGEHADYVRWCMENGKIGLPKSAGGADIYMRFFEEESRRGVICVKGQCFAAVLVDLPTITESMKTWDRKSLMKSADICQMLLVFQAVKSEEEARHVPLPSIIDSNFKWPHGLTPPMHDCVNRRFAKTISRKEIEDKEAEVERLLAEDAKCASTKWEWVDERNNAEEDGDEDAEGEMDDSLGYFGQQHETQGVEEENDFDLEADLEAAFADELFAETPATAMDTQTPTAALATPSASAALQESIEQSESEEDDDDDDDDDDDDDLDEDARARRDEEHSVKEMINDLTRQLASRVADLERTQNKILRTRLENQIKSLKAEIALKQSSIGIEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3X6</accession>
    <name>A0A2T4C3X6_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M440DRAFT_1249180</name>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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    </feature>
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            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="185" mass="20205" checksum="E6427AB65C119659" modified="2018-07-18" version="1">MGGRPWQRLLSPCSPSSRGCAKQAFASPHHNPDPAVLAATFRSARANSKTPRMAIPAPGCLGNKVHARLARRPTAPPYANNHRLSHDGAVSNRHERPPMFARQPHHRNKYQRPSTSSPRAKAPAFKRSPIHAQIVAHRHSSRGSFAPLKHSLGDYAAGEAPPLSPLWEEQNQQSILASSTDPARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="ESTER CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="182" mass="20390" checksum="B5FAF13B608091C8" modified="2018-07-18" version="1">MATLEQRNKAIVAKYFDEYWVKANVNIVDELCSDDFLISYPNHGHHRGKEGAKKMLSEFMEAFPDLTFRSYQTPLIAEGDYVAAQWVGGGTHTGRAFDDMLVGKLDKPNTGKKIHFSGINIFTLKDGKIVREIAEEGSLTVLQQLGLVPQPNPGKEIVYDAQGDQVINELVYPECVELVRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C458</accession>
    <name>A0A2T4C458_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1401789</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="35"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="576"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="814" mass="91710" checksum="77487C86E73A2422" modified="2018-07-18" version="1">MPPTLGSSLRAQGLADEQRGLLDLVDKLQFAQLDNVKLPQIVVVGDQSAGKSSVLEALSGTPFPRDAGACTRFATEIRLRRSKETNLKVSIIPDKNRPYNEQARLLQFGGDVGIDTSFDGMMREATELIAPRSIPGRFAARDILVVEKTGPEMPMLSLVDLPGLVRVANRDQSEADIQTIEMLSDRYMKSSRTIILAVIGGNNDYVQAPILKKARHFDPPGSRTIGVLTKPDMTEGIGLEDKFIGLVTNKDPENNFKLGWYVLLNPGPGDYWSSAEERSHREAEFFTKGKWTALPPHMWGVDALRQKLSSQLQRHVGKHVKSLRRQIQQALEQCEADLKAMGSGKDTIEEMRFEMGELFSASGNLVTPAVNGNYKNPVGESFFSRRSSPKGTPAQKLRARVREESERFSRLFRQHGSKVNFAPSSGSGMNLPAAGVVGDQAKKEFAQREVEPLLRQIRGNELPLDSNPRAPYILFQDFSRNWPVLAQEYKDNVGVICNEFLADVIDHVWPLRMRDALRFHFLEKKMKEMMDEAEKELKRLTDDLELELQPYDPEYEQRLIRWRAEATENGGTYTEAEEVLEKMLIYYDLTARIFTRNAITQVVERHLLLRMLGLFNPVEILRMPDSTIEAIAAENKETRDRRTALKARKTAIEEARSICASLAMRSELRAYEDEMKDQVDTDDEGQSQKDSSSQRFSVSSTLENGQQPSPSQNPALRRKRREERPRPSISADTQQSQQSVQPNGVSAPEWDESYYTTTQPAPHHAPPPPPPRPQKVGFEDGERFDATPRVDSASRAKESARHKLASLMRNGVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4K9</accession>
    <name>A0A2T4C4K9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III complex subunit Rpc37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1470446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4K9"/>
    <dbReference type="STRING" id="983965.A0A2T4C4K9"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="42706" checksum="A6D57B13A4977C58" modified="2018-07-18" version="1">MSNIDPDLMDIVHDAPKVDIPHDDNDDDPITASYQVFLNPSLPLGRRLLVLQHPNRTDNTPRPPPTELRLKEHSGMVEVDMPLDNTTAYDREKGLRWGRALQNSMAVKSGGSHGLAGGFGVGAVQQRAPRKKGDADADEDLDWNEAVRQGKVLSTQTLGGQYPEADEVQYMVGVFQGKHLHLTPVSNLIHLRPQLHHIDAATQQERQSSAAAAASTKDGAPATASSARAIHMTIKTTSDGADGVSTETMADRLRAVQTEPWRKMRYTDENEETAWDVYNESLFLRPRADPTATTAGEQQQQQQAEAEQDLEELVPTLGNKWDDTQFLESISGIKKPEPVPEPPAEQKKKPEPVAAAAPAEQQREPPRATRPRAGAAAAMAARRGGRSSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Q3</accession>
    <name>A0A2T4C4Q3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1254545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Q3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015711859" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12943" checksum="517801A41EE2C581" modified="2018-07-18" version="1">MSRQYLILQLMQCWVGGTAAGGELGKRVPASTAQQQASDYPTNPHHTISVCLPLSPRWSEPLLSCSASLSRLPLRQRPRPSPDSAALACACTQPASPNDSISGIRPFASTLLSVLLSAEGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C547</accession>
    <name>A0A2T4C547_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1331709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C547"/>
    <dbReference type="STRING" id="983965.A0A2T4C547"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="202" mass="22804" checksum="A1512E1AF86FEBB5" modified="2018-07-18" version="1">MSPKSSKAAAAAAAAASHPEGKPRYWYRDNFFLTTDKAYLEPQAVNAVFESDLMWWNDPLPEDQMRKMLANCMTVSIYHVPESEKQMQKNGPPKRPYGSDIKLVGLARVVTDYVTFAYLTDVFIVEEFQRRGLASWMMRGLKEVVDEWPHLRGLVLMTHDKAAAKMYQRELGALDWDQGPSAGLVLLEMPGGGVKDVPEDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C598</accession>
    <name>A0A2T4C598_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1401065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C598"/>
    <dbReference type="STRING" id="983965.A0A2T4C598"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="551" mass="59807" checksum="1ABF887154337A95" modified="2018-07-18" version="1">MSLNLDVSNAAVVKDEQGRPFIVVRDQGKKKRQFGNEAVKSHILAARTVANIVKTSLGPRGLDKILISPDGDITVTNDGATILQQMEVSNHVAKLLVELSRSQDEEIGDGTTGVVVLAGALLEQAADLIDKGIHPIRIADGYDQACDIAVAELDRISDTIEFSKEETSNLLKVARTSLGSKIVSKAHDQFANIAVDAVLSVADLERKDVDFELIKVDGKVGGSLEDTLLVKGVIIDKDFSHPQMPSEVKDAKIAILTCAFEPPKPKTKHHLDITSVEEFKKLQNYEKEKFVEMIQQIKDTGANLAICQWGFDDEANHLLLQNQLPAVRWVGGPEIELIAIATNGRIVPRFEDLKPEKLGSAGIVREMTFGTTREKMLVIEECANTRAVTVFVRGSNKMIIDEAKRSLHDALCVVRNLVRDNRVVYGGGAAEIACSLAVEDAAGKTPGLEQYAMRAFAEALDAVPMALAENSGLNSIATLAEVKSQQVKAGPENRGKLGVDCMGRGDNDMKAAFVIDPLISKKQQLQLATQLCRMVLKVNNVIVAGSDENDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5C7</accession>
    <name>A0A2T4C5C7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1469901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5C7"/>
    <dbReference type="STRING" id="983965.A0A2T4C5C7"/>
    <dbReference type="OrthoDB" id="4662630at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="23581" checksum="6FDBB7D9C6A7B01F" modified="2018-07-18" version="1">MKPFRLNLILLGHLPGADKAGYRCCSLEQFAKGVACSSLGKIMVDGECVCPSDMIEDAGGLCQDVTPAPSCESGLREGKCYIFKLSHGLFGLDTLQGQYDIVDQGRKFGKFKFCKTEACSGRSAINPDDEFRIYDVHGDGLSGIVSTGTWHKASRLAITRWGDGKYCLSQVFDAFASQQCFPLWVVEVPCDIRAPENNCLWREASDLVEKFWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C649</accession>
    <name>A0A2T4C649_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_309948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C649"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="17075" checksum="95049A23616CD7E3" modified="2018-07-18" version="1">MATWADWAGMDRGCTCAIHGINGIHMDVVHFRPPAPEAVLLALTTLHLNRGLKLALFFFSLSLSSQLHPRDALHELAYPWLPLLGLVWAITPDDDAWGVGICGHGARELQVSRCQRAHVCALVVPVSTIERNRLHELDWITHRHGTSGCESTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C657</accession>
    <name>A0A2T4C657_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1401350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C657"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="8">
        <location>
            <begin position="156"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="6">
        <location>
            <begin position="344"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="450" mass="49272" checksum="00D9BA2CF229557A" modified="2018-07-18" version="1">MSIPGLGQIPVQAAVSSTRTISLRPAWEWRFQVPAGGSITVKVLSGTAEKDGVELPLRNSYTFSGIKSKILTWXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVNADPREGMLSLAGTLSASVFATVMDPEAVDGWGSTPTSGPSTVPVKLPMVFHYGREAPEEDEDFYRELVARLAGAVSGRLSEDEEVRGSGVIVDSTGISEGSQIGMDLVAHIVDEFSINIVVVIGSPKIHADLTTRFASEKTSLGEQIHVVALDKSDGVVERDEAFLQHNREAVIKEYFFGDAKRTLSPQIQQVDFDALTIYKLADYSPEEKQSLVTEEPSSVMQHWTFAVMNASVRDSPDVVRAASVLGFVYVADVDEDRRKIKILAPVSGRLGDRPLVWGRWPEPYINLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7D9</accession>
    <name>A0A2T4C7D9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7D9"/>
    <dbReference type="STRING" id="983965.A0A2T4C7D9"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="69"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="197" mass="22345" checksum="88385B0BA2036D0B" modified="2018-07-18" version="1">MFLLARLPKRTALSAVAPRQPRLSLISSQPVRFKRYEAYDAQLDQDALAEARLWYNSFDASQLPKGNTTYARSSGPGGQHVNKTETKAITVIPVKELLAVLPKYLHSGVRSSKYYTAGNDSLTFSAQAHRSRSANLDENRRKLIDEIMGIYRAMTPAETSAEKKKKHQDIERRFHEARVQDKKYISAKKQSRRGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7G6</accession>
    <name>A0A2T4C7G6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1329900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7G6"/>
    <dbReference type="STRING" id="983965.A0A2T4C7G6"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="303" mass="32615" checksum="0EE37B47DDCBFA5F" modified="2018-07-18" version="1">MASAEIEQPQGGALQTAKDLFSGAVGGIAQVLIGQPFDIVKVRLQTSNQYSGAVEAAASIYKNEGALAFYKGTLTPLIGIGACVSVQFGAFHAARRWLETRNTSHGKASDLSYAQYFAAGAFAGVANAPLSGPIEHIRIRLQSQPHGAGRLYDGPLDCIRKVSHQSGGALRGLYRGEVVTVWREAFAYGAWFTAFEYLMNADAARNGIDRKQIPSYKIALYGGLAGEALWLASYPFDVVKSKMQTDGFGARQRYPTMRACFAATWRADGVRGFWKGIGPTLLRAMPVSAGTFAVVEMTMRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7I1</accession>
    <name>A0A2T4C7I1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1331399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7I1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7I1"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="162"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="787"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="953"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="991" mass="110504" checksum="2BFC3454B6732A78" modified="2018-07-18" version="1">MASEETSWGNEGFAAAEGDHTQHSDEQVDNFAQDSHVSGETADNGTEDGGDYDPEYVPDESVVPDPPVPEKTAPAVPSQRPPSSKPKMSGGFLVEASDEEDEDEDEDEGGSAAGPGQRESSASQSQAGQPTEIKMATAPVPSVPTNVPSNVTATPVASLDPVALLEARIKEDPRGDMDAWLNLIADHRRNGRLDDLRKVYNRFLEVFPQAADVWVEWIEMELGMDNFVDAEQLFGRCLMSVPNVKLWTVYLNYIRRRNDLNNDPTGQARRTVSQSYEFVIDNIGVDRDSGNIWQDYIQFIKSGPGQIGGTGWQDQQKMDQLRKAYHRAITVPMSTVNNLWKEYDQFEMGLNKVTGRKFIQERSPGYMSAKSGNIALDNITRDLKRTTLPRLPPAPGFEGDQEFRHQVSLWKKWIEWEKEDPLVLKTDEPKVFAQRVLYCYKQALMALRFWPELWVDAAEWCLHSDIAEVDKEMGVEFLIQGITANPESVLLALKHADHIEATSPLREGDKAEYAKAVRKPFDDVLNRLYALGDKAKEREKLEISTLKQAAAQEASLQQSIEHNYDDNSDEGASKKPPVEERIAAIQKGYAAETNILSRTISFVWIAMARAIRRIQGKGNQTDGGLRKVFTDARQKGRLTSDVYVAVALLESVVYKDPVGAKIFERGARLFPNDEGFIVEYLKFLHSKDDTTNARVVFETCVNRLVANPETLHKAKPLYAYFHKYESQYGELSQIHKLEARMAELFPEDPKLKYFAARYSSDKFDPVAAPVIISKAAQMRPKLAAPIIEQPASSRNSFPPQREQSPRPQYVRATASPKRPLGPDDEELNPPKRLARGASPLKGAAGRRLDQQRRNQSSALHRDITFLLGILPPAHTYDSQRLNAAAMVSLLRDTPLPDYATWKAQTGGQYRFTAPVHGRQASGDFSRPISPYGRIAPASNVYRQSPLRAEAGTAFPAAPYGGTDANAPPTQWPPAPTGYNAPAPGQYGGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7R1</accession>
    <name>A0A2T4C7R1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1438102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7R1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7R1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="294" mass="31965" checksum="8E6A9A469CF4F566" modified="2018-07-18" version="1">MGSIAKTVVATGASSGLGFEAIKQLLLQQTQPYKVILGARNPQGTIAAYDALGYDRSGHAVTVLPLELSDLRTVKTFSQQVLEKIGGDKIDYLLLNAAISDGAEKPGPHGWRWCEALVVNHFSQHYLTHLLREKLVESKSRVVFVSSGAIRRITDPSTLEDTLKGASGANGQDVYCASKFVQLLNAHWWRRQLAGQCDVVAVSPGLIPGTGLGRGNGLKLTMDMADAKPVSTGAQSILAAFTRSDFPSDPDQIFLTSWGEWWGKDVIEKSLDKELQDKWSWSKEEIEKEAGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C835</accession>
    <name>A0A2T4C835_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1390958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C835"/>
    <dbReference type="STRING" id="983965.A0A2T4C835"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="485"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="798"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="725"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1233"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1263"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1280" mass="143319" checksum="66D713AAD7B7A2FE" modified="2018-07-18" version="1">MAGVDENTAQEPDSRSSSSRAQPENGGTGTAPAAEHSTATAASTRSPQQENAPAPPKHSTIAPKPPGSKLSPEAARTASPSSSSRPRAGVGNSPALPGEQSFFETTALTPTLTADETMSEDAVREHFDDVESSFLPTLSPIPTAPATAGATADDSFVFDLPAKRPAQPPRSSTQPEGQPKSSHFRPEPRYGSSYKAEQDYTHQFDFHPDSEDDLTRASNTTSNLEDFDSSPAAAAAARSIHRATSAAQNNQNTPRVGAQEGERGKNGQDGAGGSGPGSQDPSASSFRHSQQAAEPFDTSGSPGHAMRNRRPKYVRSNRFSSSRSSTSSFITNPESQEDSDATVGTVGLGLDYALHSGGAVPNTGMSRAPSNLLLRSISTGSMTSGMGTDEFGDNTRQLEPLAEVDTPTRGRDNYGMVTPKTKDSMNTAPTDTVIAQHVKNVHVPDSVAKEFKFENGLQTPRMSVSTSTAVNSAKTTGKGGNQNWTLKEQSSTIERLSKENFDLKLKVMFLSKRLDTLSEEGLKEMISENVELRTNLAITTRDNKILRKRVKELEKKEKEDEERPSTARSAASSTDQTAKMYNEEAQEREEELMFLRERVETYATEIERLRSETMDRESEKKKLSDIVKTLGERSGDAYGRQEEADVWKDLLEQETARREQADEDNRKLRDEVFRLKKEMSGAGSGMMHHTTNIYNITKKPRDRNASPGRPMSSVSGDMDGSHANFSAASTLVDELRRESEQLRHENAELRREVGAQTSMLTSRNREKERLYQEIEDLKMAQRRGGPAPSTIDSLLERSASRAGHDRPGSRGSVRTRQLTAEDEAEREELENQIAEARDKYNKAMLENQDLRGTLDRCLGDLEELSHEKRIAEENILALQEEVENMGKDLVALQQERDEALVAEQALEDEMEALRVEAQGEIDLLDAEIGKLNIELRDRSENFESLQKEMRQMSEALLSLEDEQDQKLQHIQRLEEEQANLTHRIQHMEQEQESSNKELEELEQKLLEANEKNQRLSVQQESSQGEISFLREEQEADKIRIGDLEAALSNTQRSLEDEKERVKELENRMQEERAQWEDVTTKKDADVQQIFANLQRENANAKDEVKRLRKSLSSREVEATEWKERLLELENNLREALGDLNGTRSSLLKSIARMQRELENTVRELDTSKAALVEKERIIKQRDSLMESHALETRKITELLEKERVAHRNTKSQFESFQKTHQHLTRTASTQDVRISELEATRGQDRRRNQDRQAARQRLGGLENENRDLREKVRRANADTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C847</accession>
    <name>A0A2T4C847_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome oxidase c assembly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1400700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2T4C847"/>
    <dbReference type="STRING" id="983965.A0A2T4C847"/>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27939" checksum="48BA3BC773726536" modified="2018-07-18" version="1">MASRIGPRSVKDATRFTSTIPHATSKSATSAATPSAASRIPGETPEQRVRRLRQAHLAAQRAQVSKADKVIDASRRFFDVAHRWFTVVAGVVSVYSVWDMLRYNRARRAEWIEAQRKFEADELSTARLAYLKGDATEEQIALVEEANREAEAKGVRLPPLLSPPEHRTHFEEHVKTAFDTGKLAEGKGKGLLGFLWGGSDSNTASSGTENNSATAIVKDAWEKEKENQRSGGSLDQLGLETASAAPEPKKKGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8U2</accession>
    <name>A0A2T4C8U2_TRILO</name>
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        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1354508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="544"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="764" mass="84209" checksum="F3E4B901D2E0A477" modified="2018-07-18" version="1">MAQPSTPGPASSSVSLFGQTPATHAGGTPQPGMTSQTSSETLSNAQQAPASASSSNNTYIMPNSPLKARPLADGYRPKVTRTLGQRPACLVNASVTYCGNNQIYAFGGFDQYTDEVYNHVLRLDLTSHQWSLVDNYGDIPGVRMGHTATLYKGDKLLVFGGENEHRTYLSDLIIFDLKTAHWTQPLVSGPIPKGRARHAAVLHEDKLFIIGGITGQNNYVLDDICYLDLKTFTWSKAWRFVGRFDHSAYIWGDRVWVFGGLSEDMDKISDLWWLDLKGSPEFDSRPHFGVVDRHSTAHRASSSPRPPYTMAPNPVVGTSGYAANSRTAQVNPPSFQVKSYAPMAPGTISALKFVSGPTVPSQGSGIHFHTYSSGTLLDFVTPAATITHRECSLSALDLSTLRWQKLADGREIYKTGYRWHYCTMNEDGTKAWLLGCPVDPAATDLGPNGYEEYLSDIMEVDLRRYGFLGNNLAPETLAQSRPSFTTRLSDQPSKGLGADLAKLFNQPPESGSGTDFIITALADDADSDETLSSGLIRADDANRDQSWLSADAPTSMPIHVHKLILQARWPHFARLYNAQMAEFHTKKMHIPEPYSVVKSFLLYLYTDNIHGTTEADSDATTDLSDVAGLLVMSNIYNIPHLRLLCVNRLAKELDVEHACVIWYCAGLASEEWLRKRAATFCMTHWGRIVRTQGFLRLPRNALVELSQEIDMEGRVVAGDELEWGSVSGRYSDGTGHGTRKESISSSTQMQIVESDDDDEDVEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C905</accession>
    <name>A0A2T4C905_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1351165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C905"/>
    <dbReference type="STRING" id="983965.A0A2T4C905"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="507" mass="55224" checksum="3F929E0F082F06B5" modified="2018-07-18" version="1">MALKAFKANRAAPSAAHVEESPSALETGSDPESKEPPSGLKLDASGLPLVPQPSDHKDDPLNWPYWYKYYVLGLLCLLAFVVQFGAGMVPAAFGPIAASYGVTHQQASYLTTSYTLLGGVTPLLITPFVNLYGRRPAYLIFTLIAIGANIGSAYAPSYGTQILTRCIVGIGASVALAIGGATICDMFFQGERGKYIGFYALALTNGPHFGPIAGGFIAKDQGWRWIFKVNAIMMGAVLAIYLVSFPETLFSRTEFSALENRSYWQRLAFRGKVIDRKLKGSDFLANFKMLKYVAVVLPCVYYMTTNTYGSIVFVLTASSISERLYHFDTAQNGLLLGVPLTLGCIIGECCTGWISDWLINRYARRHDGYRKPEARLHLAPLGLFLPAGLIIHGVSVANRAPWIALAVGMTVASIGVQAGTTLTYSYISDCYKPQAAEVSTIINLFRQIFAFTIGFYALPFGDSAGFDVAWGVFAVANFVTWCPLILLIYRGEQIRKAQGVPAIHRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9C1</accession>
    <name>A0A2T4C9C1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1328628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9C1"/>
    <dbReference type="OrthoDB" id="4161238at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="117" mass="13346" checksum="4D6BBE70C85EC2D9" modified="2018-07-18" version="1" fragment="single">YIAKSFARVAKSRANNPGHATRTARERAHRALENNKFHCDVCNLSFSSRHSLQDHHKRPKHLRKSQQPTNPFVCKPCDLGFHNKSNLTRHEKSERHAKQVQLLAGQTFILLEKGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB47</accession>
    <name>A0A2T4CB47_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOM13-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1352471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB47"/>
    <dbReference type="STRING" id="983965.A0A2T4CB47"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="125" mass="13571" checksum="124DA69A13540874" modified="2018-07-18" version="1">MSTDDLSTHLADSGITMRSDSEQYSPGDEVSSPSSSTSPVILYKPPTAWTLLRSAAINLLLPFINGMMLGFGELFAHEAAFRLGWGGTKVFPVSRRRAHPIGPGIEVRERPERPGPSLNDFASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBB9</accession>
    <name>A0A2T4CBB9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1203325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBB9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="140" mass="16301" checksum="1DCF3E4AB07DDBE7" modified="2018-07-18" version="1">MKMHAGRDLFLERSMLFLPCFFSLWFLRFFFSIRRLAGHCMNLHGCLCVQTESNVTVAGSEKWVACDLWFVMTIVFLHRLEILAKEIARACMYRRMIGNTAPDLDGMAMLKPGFTVTRFFPQCGNVELSTRRDDDAYRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBH5</accession>
    <name>A0A2T4CBH5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_49771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBH5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBH5"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="57"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="472" mass="51064" checksum="8CCA5EEAC66313D0" modified="2018-07-18" version="1">MSNTTLNLHSDSEKSRNDLKEVPNRDFNVLTGETGAEFREDAERAIIEQGEHKFNRLGWKRLTVVLIVEAIALGSLSLPSAFATLGMVAGTICSVGLGLLAIYTSDLVGMVKLKFPEVAHYADAARLVAGKFGYELVGFMFAFQLVLLIGSHCLTGAIALGRISEDAICSVAWAAISAVVLFLLALPPSFTELAIFGYIDFASIIIAIGITMIATGIQAHNAEGGLSAVPWSAWPKENLGFTEAFIAITNIVFAYSFSICQFSFMDEMHTPKDYKKSIWALGLIEIAIYTLTGAIIYAFVGPEVESPALLSAGPLISKIAFGVGLPVIFISGSINGTVVGRFLFSRMFKDSIIRYINTPKAWAIWTAMIGILTVIAWVIAEAIPFFSDLLAISSSLFISGFTYYFPAIFWFVLLREGSLFDRKNLVHLILSSISMIVGLIVLVGGTYASIVDIKNQYENGSVRGPFSCASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBT9</accession>
    <name>A0A2T4CBT9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1389119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBT9"/>
    <dbReference type="STRING" id="983965.A0A2T4CBT9"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="269" mass="29041" checksum="9F5DF5D9FB08E62A" modified="2018-07-18" version="1">MGHDETPPGLESGLVLPSGRTSSDNSQHFPDKAEIERLGRARPAVLPSLVTEVFFVVTIVLSMTMSEYFIGGFNIVLPPIADALAMPEDVRTWPAGVINLTTAAFLMPFSRLCDMYGARSVFLFGHVWYMIWSLVCGFSTNTVMLIICRALQGIGTSAFTPAGLALLGQTYRPGPRKNLATAGGLINTLLYLGLAFWLGIAEMAVSEANRRALPEGLSLREQYKIGFWIGVALAGVSMLMVVTIKIDRAAAELTADEKAARAEREGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBV2</accession>
    <name>A0A2T4CBV2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1460697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBV2"/>
    <dbReference type="OrthoDB" id="4900590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="19097" checksum="A0DD902D4334840A" modified="2018-07-18" version="1">MSDRQPRYKTPTEHTRSPKGSSNPSTPSIVSGSRWGESRTLAAKAGAEESIGPGNGNGNQGTGKLMAPLKAFVGAAAKIAEEEASQRRWLARLEAGRAALRERYLGEDRTRGLTGLNEEATQCSISELSQLMEGVCLEDEGLAESESPDEEGKGKKKDEDWVVVKEDFDVLVFLDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC38</accession>
    <name>A0A2T4CC38_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Glutathione reductase</fullName>
            <ecNumber evidence="4 20">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M440DRAFT_1419547</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="4 20"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC38"/>
    <dbReference type="STRING" id="983965.A0A2T4CC38"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000671">
        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="7 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 19" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="22">
        <location>
            <begin position="10"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="21">
        <location>
            <begin position="357"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PTB79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="470" mass="51113" checksum="6379C442E679FA16" modified="2018-07-18" version="1">MAPITTKETDWLVIGGGSGGLGAARMAASKYGVKSMIVENSRLGGTCVNVGCVPKKVTYNAAALAEAIHDSKHYGFSVQETAPFDWTTFKTKRDAYIKRLNGIYEKNLGNDKVEYLHGWGRLLSRNQAEVTLDDGSKVVVNAKKILIAVGGKPTPPPEIPGAEYGINSDGFFDIAKQPKKVAIVGAGYIAVEFAGMFNALGTETHLFIRYNTFLRHFDPMIQETVTKEYERLGVHLHKQSLTTKVEKGADGKLSVTYRDGEGNESTVHDVDHLIWAVGRTPLTKGIGLEEAGVKLNEKGYIVVDDYQNTSVDNIYALGDVTGQVELTPVAIAAGRRLAHRLFGPPQFSNLKLSYENIPSVVFSHPEVGAIGLTEPQAIEKYGRENIKIYKTAFTAMYYAMMDPESKGPTSYKLITAGPEEKVVGLHIMGQGSAEMLQGFGVAIKMGATKEDFDNCVAIHPTSAEELVTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCJ9</accession>
    <name>A0A2T4CCJ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1389302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CCJ9"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="101"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="604" mass="65607" checksum="72BA1DF9D5DC726B" modified="2018-07-18" version="1">MADDKASLPEQTPHPPSSSSASTSSETVTTPDHDVEAQRQAPPSEKISHWRVLLDQTGVTQQVLEHNYSGQGTTESPYLVEFLPGDRWNPMTFKDSFKWTITLIQASATLSVSFASSAYSGGVSEIIREFNISQEVAILGVSLFVLGFAIGPLLWAPLSELYGRQKTFFISYMALAAFSAGAAGSQNMATLIILRFFAGAFGSSPLTNAGGVIADLFQAKQRGIAFSIFAMAPFLGPALGPIAGGFLGESKGWRWVEGLIAIFTGVVWIASSLAYPETYAPVLLRQRAAALSKKTGKVYISKLEEGQPPKTIGSQLRVSLLRPWLLLIKEPIVLLISLYMAIIYGTLYMCFAAFPIVFQQGRGWSPGIGGLAFVGIAIGMTLSTVGSVFDNNRYIRAAARSPDGIAPAEARLPPAILGSILIPIGLFWFAWTNGPSVHWIVSIIGTIFFASGIVLVFLSLMNYIVDAYVIFAASALAASSVLRSLFGAAFPLFTSYMYKDLGIHWASSIPAFLALACVPFPFLFWKYGAKIRAKCQYAAEAAEVLARIRAKNVRVTEDEAAAEVEKHELERRESRALQREQSRASRASRASRASRFSRFSRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCK3</accession>
    <name>A0A2T4CCK3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_232793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCK3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15757" checksum="1A592BBE1C33EB22" modified="2018-07-18" version="1">MYDDETTARAFCIRHQQADLAWSSRPPRFVWLVLLSRQLVSFRLLWSVCVSLSVFLSLPLSPAPSPLLPLLVPFFTSSLFSFSLLLLLSPPSLPVEPPIMPFIAHSADCTLHDAWLVRHTSTATKSTSTSTSTRARESITSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCP5</accession>
    <name>A0A2T4CCP5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1326183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCP5"/>
    <dbReference type="STRING" id="983965.A0A2T4CCP5"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="507" mass="56455" checksum="FA48F034FFE70B55" modified="2018-07-18" version="1">MLSSARRWVHRNRTPIAIGLGVVGAGYAVTQYVMSKINDARERMSSDRIAKENLRRRFEQNQEDCTFTVLALLPTATGNIVTALNTEQITYEIQQIKSSARSLKGIQTTSPPSIADTTLTEDDSKSTVSVPVELGMPFTSDGSQQELAPPRPRPRKTKRQLWDDLTISAITRSFTLIYTLALLTMLTRVQLNLLGRRSYLSSVVALATGSQQATINLENNDDDNPDQSYGSDFDTNRKYLTFSWWLLNKGWMDVMHRVESSVRTVFGSLSPRDLVTFDRVSQLTAEVRKLIEGSSADERKRSDWLTFLLPPKDKEDEVIRESGILDDGGLSPEGGSPVSSAALRRLLDETADLIESPAFSHVLTLILDRGFSHLVDKKLATEAFEFSLDDSPTTVATTASLKRSRAILLPKILSVLTRQAHVIGNGVPNEYLQEMESVRDLEAFSAVVYSSNWENEMKDEGLMESAVYLKSEDTQSQSTQVDSSVVMVDRQAASLEGAWERATEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCZ5</accession>
    <name>A0A2T4CCZ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1327169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCZ5"/>
    <dbReference type="STRING" id="983965.A0A2T4CCZ5"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="42"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="346" mass="38704" checksum="B84F7FC4B6801676" modified="2018-07-18" version="1">MDTSKLKPNDPRVKYETKQIRGKTYSYILSEPQDPQKQLHETVVLVHGWPDMAFGWRHQIPYLTSLGFRVVAPNMLGYAGTDAPRDLGEFTLKSVAADVAELARSFVGPEGQIVLGGHDWGGAVVWRTAYYHPELIKAVFSVCTPLHPLSAEYTPLEDVIAAGHMLNFKYQLQLKGPDVEGRIQGKDMLRRFFRAMFGGRGPNGEVGFSTSEGLHFDVLDKLGAPPLLDEEELEYYVEQYALQEAPELRGPLNWYRTRELNAKDEMERARDGPPLRFEMPALFVAASKDNALPPAMSKGMDGFFRDLTRAEVDATHWALTQAGDEVNRLIGEWLDKALNGAVKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD33</accession>
    <name>A0A2T4CD33_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1460982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD33"/>
    <dbReference type="STRING" id="983965.A0A2T4CD33"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="433" mass="49024" checksum="DD45ADBEA22903B7" modified="2018-07-18" version="1">MADVLKNMFGGAKPEQPAAAQPDSDFADFAGAPDAVPEAAPQAATTLTGSAAQPTGDVVWTKWYNVHERHSLSEFKPEGIILVLASVIFLLHIFGTRANRAKARAWIQAHAPVMKREFASVGFRGVPTLDADFDPNSFIKEKSLFEFASYATGRQNVAFMDVKITLAKRFNPFLHYIEHGLSLITDTFAAPEEAVEATIYPFDGKEELTLPPSAGGVDARPRDSKSTYDGFVWAIVNKSSMQRLRDERYDVSLTATKDNSKLPEWLTIMSESAEITETFLTPELIEAVTKAGDLFDYIIISDQPVEKPIRLEETTPRKRVFLKYRLPSNNNYDQFLPLFEHFLRLPDALVRDAHFRPEVLKRVRATREAMIAQIKKAIEEEKNEERQLEKEKAKKAKRDAELKGLDAKAQKKYLEKEREKELRKSQKRMTMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD40</accession>
    <name>A0A2T4CD40_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1389455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD40"/>
    <dbReference type="STRING" id="983965.A0A2T4CD40"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="181" mass="20199" checksum="1DB848D4DE2649C9" modified="2018-07-18" version="1">MSSSSAARSGERMIHQDFIARIRFSNALPPPPNPPKLLDIPNTGLASGQYTTPQKAVYYYPIMQKSTIRPQRTKNIARTNYGLAEDDEVQVVDQLELTVEDPTEEMRGAMKMYAEHPLGWDQEEGAEEHEHEHIEQSIEEADVDADGEEAERNGASSPGGQEQRSPSAERDAEGDEDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEV0</accession>
    <name>A0A2T4CEV0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1388449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEV0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="12957" checksum="62F8CC7740FABAB8" modified="2018-07-18" version="1">MASSCCAGPYTGAPLFFFVLSVTAAYYEYYSYKSRSGGSRDSDKDTADACTPWHPSSGRSEAVQTPTNMAKGETPGAAMIFMYCNNKKAGDTETRRAALLKDPAPRANSRVPPLVLRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEW7</accession>
    <name>A0A2T4CEW7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEW7"/>
    <dbReference type="STRING" id="983965.A0A2T4CEW7"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="254" mass="28075" checksum="6F9EFE05494CEDA8" modified="2018-07-18" version="1">MAAPRVFIVRHGETEWSLNGRHTGRTDIPLTANGEKRVIATGKALVGDDRLIVPRQLCHVYVSPRKRAQRTFELLNLGISGPLPWHPHGTPVGGGLECTAKVEVTEDIREWDYGDYEGVTSPEIRRMRAEQGLEEAWDIWKDGCPGGESPQDVTDRLDRLIADIRSRFHEPVLRPAEGQQPHKVSGDVLIVAHGHILRAFAMRWAGKTLQEGPAFLLEAGGVGTLSYEHHNIDEPAILLGGAFVVDIAEKGMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFJ8</accession>
    <name>A0A2T4CFJ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFJ8"/>
    <dbReference type="OrthoDB" id="5146389at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="168" mass="18203" checksum="2A796A60A5B2F6BB" modified="2018-07-18" version="1">MAPGYRSPFDHHPPPPPKTIHDHHRPGAMLPLLAIIICMSVIVRLALITIRASFHRQQRGPEDDTLLCLPAAIALGEAAMAKSLVVRSGRDPQRAMDSRQWSLCEGEGCGVDGGSGQQPLLRAEGHGSLLSEDTSSITQAARQDDAHGKAYINWHGTNTLNTSWGWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG10</accession>
    <name>A0A2T4CG10_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1397876</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CG10"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="120"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="352"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="856"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="856"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB80507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="918" mass="101145" checksum="D8CC2C2F27938B08" modified="2018-07-18" version="1">MPGRRAASPAPSEPELDILDSLYPGDDDNGEQGLGKDGQDGLDFDDLFHAGAAGGGNDDDDDEAYIALQQAASYRKASNLKGRTVKKGGGFQAMGLNANLLKAIARKGFSVPTPIQRKTIPLVLERKDVVGMARTGSGKTAAFVIPMIERLRAHSSKFGSRALILSPSRELAIQTLKVVKELGRGTDLKSVLLVGGDSLEEQFGFMSANPDIVIATPGRFLHLKVEMGLDLSSIKYVVFDEADRLFEMGFATQLTEILHALPPSRQTLLFSATLPASLVEFARAGLQDPSLVRLDADTKVSPDLETAFFSIKGAEKEGSLLHILHDIIKVPLGPPAGANEETEKGSRKRKRQPDNGAGKPTEHSTIIFASTKHHVEYLYNLLKHAGFATSHVYGSLDQTARRIQVEEFRMGKTNLLVVTDVAARGIDIPVLANVINYDFPPQPKVFIHRVGRTARAGQRGWAYSLVRDVDAPYLLDLQLFLGKRLVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXANDEDGSRGAKMIVGESGVKIAASFSSGRFDKWKRANRVHKLPQVGELVKPGSGNGVGQLPSGVRYKHKKELAPKEADKYRDDFHQRKKRVNEAREKRVGRFKDGMGSKKEIKGVTDIRKAREEKERKRAKTGRHQTGNHKGGHKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG49</accession>
    <name>A0A2T4CG49_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1460421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CG49"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1442"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1782"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1810"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1844"/>
            <end position="1854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1854" mass="204999" checksum="EBBCB924148CDFEF" modified="2018-07-18" version="1">MQPDNMQRSDEGGSANHGAAAPQNAISRPFTLQESLPYSPQTSTVPFVSEIIPDPSLGLGSPAPSISDLFPHSEYERLNKEALGQPHLPRSTKQAVDLVLHEIKPSQRTQYNFKSVLAGQPNPRSASLSQGLSPIARVVYEKVGGYFKATKPNAAGPHAAGVNGNKSHSLAAGMAVPSSLPEDPVAPSDGQARPKVRQSRIEVLIPSRRGFDPSAYVDATASSNAQVPPESPVQKTASSVLPNAPDDDQNAGSASPDLNNLNYNTASFRVELPSSHIKKDEYLEFAHVPSAPDNLSSRKDDRHAAPDGQGLVSSVSLGQQQRAETALESINTLMRSVFAAVGHAIAMEPGHDQVVTLNDHNEVIMNGGMHQKLQSAMQKAISLKCFHRVPIEDLLHIMKLSDNSVRAAEALELRVDETWDEASLESWVRQLPDVELGMKAARTCLRILSGGREDKRLYAEGAMTRCFNVFKTVVEDIIIPLVELRNSSSSASLFRMMVKHKKALSSTFVCCQRLFATLAELITKVELSESVLNALEYTASKLVFVENAYFEKDSVVGVQRFDGIRSVAMDMLCQIFLIKPDQRQGIIDDILTSLEKLPVGKQSSRHFKLADGGNIQPVSALLMRLVQASSGRVQENEGRRTAALRNLGDEDDEMEEDAESEDELPDKTTKKEMLSSVNSEEQGAQQYAVAIQELEAAADPLSESAARNASYIINYIVKRAIGSTKSGDTPYRNLLDLFVEDFTTCLDSPDWPSAELLLRLLMLMMVQLFEAPRTAAPAKNMALEMLGHMSAAISRLRSHVKRTANLFEVSNVDELSRYLAALACHVLEQKSPLEHIVAWDGPYRATLEFLQARLSDDPYLFSAVSYLITDWATRVHVGYDSLQDNDAERDQELGRLAYRLRMMIQDRRWLSNEYTFKAVSATQAKLSYSILLLQSPLFESFNKILNILLGSMASDQATVRSKSLKSINQVLETDPSILDGDSMVIQLILDCSSDSSTQVRDSALGLLGSCIALRPFLEAPLTPKVIDRFQDAGVGVRKRAMKLARDIYLRNHDNGLRSSIANGLLRRVQDPDDGVRDLARQMIEEVWFAPFYGRDDSAAFQTSLAEHVALIIQTVKTGNVTEILDKVFQSILRPKDKSLEGPFSVCSQLVSSMFGLIDSGEQEEGGPTGRDALQVLTIFAKADPKLFSLEQIRLLKPHLASFSGTDELAAFRAVTVIYKRVLPRLPTVPTEFLMEIRLQLLKGIGKIASRGALDDLIACTKVVCDLLNDFGPLANLVASGILGIQKLRAGGTLLDSKKINFFSAYSILVGNVGKHCDLDKQKAVFRARLPKWEGDSIPRLIVDVLSPFTSPSQPLEARKAALDAIGMVCQSWPRNYVLAQVYTAFQQVFQEQVPILEAMILKSFKEFLLTEESRSELGAESGATDKKRELTVMGGTNFDDVASATTQRFLKDITRIALGSLDEHAFLAMEVLGSINRQGLTHPKETGVTLMTLETSSNRKIAELAFLEHRSLHEKHESVLEREYVKAIQSAYNYQRDIVKDSHGAIPEVFQPKLHLMMEVLKISKMKNRQRFLEKLCGQVDFDIAQLDATEEMPPHLDYSRFIIENMAFLEYHTVGELQTVVNMMEKIVSTTGANLAHLIELEVFNVRLDPDKTEQDEVTGQLMTETTEAQAIAEGDILLGVKVDPSRLRQLTTGAVILHCLWEARTHLRRLYGMGTGRHDGKAKALAKDLNKTPMKVQGVHGERFWDEVTAHVSSLETMSKMAHKCKAFVELMNVDKELKVQDDDEEMAMDGPSTPSEGDAGRATPERGRKRKGAGTPGGRKKRARSGSQPRKRGRPRKAAEPLDEDDDMEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGC8</accession>
    <name>A0A2T4CGC8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1398008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGC8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="54" mass="5832" checksum="CF676A67C6D2B8B2" modified="2018-07-18" version="1">MAVKKDMATTGSACYCPKLETVCWRDAGLSLLLSYSPVNHAVCLLAEGMLVLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGX0</accession>
    <name>A0A2T4CGX0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1389012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGX0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGX0"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="373" mass="40527" checksum="0F792E0A61F0792E" modified="2018-07-18" version="1">MSFRKRNTVIGISGAAPELQQKKVSIPGTRPSPHDGRLTTSTGTLSLDQLLAGHAGLPVGTSLLLEESGTTDFGGILLRYFAAEGLVQGHSVHVLGFGDHWRRELPGLAAEGRSKESKSSGASGSKMKIAWRYETLGSRAAPSRGPSISDSTEGMAPFCHTFDLSARLDDSVAQGQFHTTRSIGMDPSQSLFRRFINDVTSRIKSSPPTSIHRLVIPSLLSPTIYPPSASRPQEVLQFLHQIRALLRQYPFRIVAMMTLPTSLYPRSTGLIRRAELICDGVLELIPLQQQPHHPPERSSANDTKAQGLFRIHSLPIFHEKGGGLEGSWVKEDMSFKLSASSGLVIAPYSLPPVLDEEGPSNAPANENKPKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH26</accession>
    <name>A0A2T4CH26_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1395997</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH26"/>
    <dbReference type="STRING" id="983965.A0A2T4CH26"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="312"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB80856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="359" mass="41350" checksum="4CDC7B0C67E514C7" modified="2018-07-18" version="1">MTYTKTEAPRQAVKLAKVVANSHASYRLAGHPALTRRLASTGRPVCSSHLFHGQTVRAFSTTPVSQLRDFFPAKDTPHIKKTPPAWPHPGFTIEELQQVTPSHRPPRGFGDWAAWKIVRLARYFMDKATGMDREQQVDKKHPTTSVRAEKPLTEAQWLVRFVFLESIAGVPGMVGGMLRHLSSLRYLKRDNGWIETLLEESYNERMHLLTFMTMCEPGWFMKLMIIGAQGVFFNSLFVAYLLHPKIVHRFVGYLEEEAVHTYTRAILEIEEGHLPKWSNPNFRIPDIAVQYWHMPEDHRTMKDLIMYIRADEASHRGVNHTLGNLNQKEDPNPFVSTFKDREVPKPALKPEGYEREEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH65</accession>
    <name>A0A2T4CH65_TRILO</name>
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        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1387444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001075">
        <property type="entry name" value="Zinc finger, C2H2-type/integrase, DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="298" mass="32511" checksum="0DD8B697F4437738" modified="2018-07-18" version="1">MHGSDASGRRVSLLNDDEVTRFTARPSAFTWPSAQSQHYGSDSSLPNTPALLRSDSFDSQLSEAAISPLTPPGDGFFRGVRPLTYAFGRDYAEGPPTKRPAYGPCSPPASGEEDSSAAPCVPERPVKRYPCRYRDLHGCEKTFTTSGHASRHSKIHTAEKAVHCQYPGCHKKFTRADNMKQHLETHFKDKTRSSSGSQRASKASLTSNARRSSTASSRSMSSTTGPDSFVFWDESELRQKQSLSPTSPLSQPTRDWEPGMGGIELPLLNRPSAVGRMPSGLDTLAMAVEMDCREGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHC0</accession>
    <name>A0A2T4CHC0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1321459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHC0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHC0"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="258" mass="28076" checksum="28574FC7B872F602" modified="2018-07-18" version="1">MSTITEIETDEQWQQLLTTAHPSTLIIASFHAPWAAPCAQMATVLSTLASEYHVTDPPSTKWVSINAEELSDISEAYDVTAVPYLVLLRNRQVVETVSGSSAVKVRTAIEKHAKKDGAAAQDAAAPNGVAETAEVAQSDAAAVDPAKQKEELFKRLDDLVKAAPVMLFMKGTPSAPQCGFSRQMVGILRDHSVKYGFFNILADDDVRQGLKEYAEWPTFPQLWVDGELVGGLDIVKEELSSNSDFFKPYSVNSEETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHD8</accession>
    <name>A0A2T4CHD8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1002824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHD8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23879" checksum="30B399F96B1F52F2" modified="2018-07-18" version="1">MFAGISQHRIAKAHPIESTSSSFPSCRLWSRLGLAAPSRLLFLPRIGCFCRVFLGCVHLLLSFSSIFSVILSFFSVPPTPPFSLFKLSQLSGSLSSFLYLLSFVCSPSVPLFASLVSLSFFSPHTSPLPPIHPTSHPRKTRKGSGFFSPLLSKIERHAASCALSQTPGAATRPLHPFLPPLPPPPVQRAAASGTRRPSILGLTASQSANQILHALDLPRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHG4</accession>
    <name>A0A2T4CHG4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1387516</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHG4"/>
    <dbReference type="STRING" id="983965.A0A2T4CHG4"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB80990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="445" mass="49579" checksum="BF5952FAF4EEA1CD" modified="2018-07-18" version="1">MREIVHLQTGQCGNQVGSAFWQTISGEHGLDASGVYGGTSDQQLERLNVYFNEASGNKYVPRAVLVDLEPGTMDAVRSGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAENCECLQGFQITHSLGGGTGSGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSMHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVSTSLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSPGAHSFRAVTVPELTQQMLDPKNMMAASDFRNGRYLTCSTIFRGKVAMKEVEDQMRSIQNKNSSYFVEWIPNNIQTALCSIPPKGLKISSTFVGNSTAIQEIFRRVGEQFTAMFRRKAFLHWYTSEGMDEMEFTEAESNMNDLVSEYQQYQDATADDGEEYEDEMPLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHS4</accession>
    <name>A0A2T4CHS4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1434958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHS4"/>
    <dbReference type="STRING" id="983965.A0A2T4CHS4"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="89"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="23738" checksum="56AC3CB655E1681A" modified="2018-07-18" version="1">MAEVIKPASALIPLRAASAAAFSTTSRQDATSLTPSPHSSTYGKARKEVALPSEEGTKGVIQYALTSLDVIANWARQSSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTSEALMYGIFQLQRKMRNTKITRMWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI01</accession>
    <name>A0A2T4CI01_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1459456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI01"/>
    <dbReference type="STRING" id="983965.A0A2T4CI01"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="290" mass="31432" checksum="60F0CC210E0C3347" modified="2018-07-18" version="1">MNTFRFLRPAVGKVPFQRSTLPRVARAYSSKSYEYILTSTPKPGVGQVTLNRPKALNALCTPLIHELNDALNDFNASDETSVIILTGSQKAFAAGADIKEMAPLTFSEAYTKAFIESWSLLTTQVKKPVIAAVSGHALGGGCELAMMCDLIYCTETANFGQPEVKLGTIPGAGGSQRLTRAIGKSKAMELILTGKSFSGADAERWGLAARALPSYEALMEETLKLAETIAGYSKVAVQACKEVVNKSQDLGLRDGVEFERRVFHSLFGSQDQKIGMKAFAEKKKPEWTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI13</accession>
    <name>A0A2T4CI13_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1427141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI13"/>
    <dbReference type="STRING" id="983965.A0A2T4CI13"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="475"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="567" mass="62770" checksum="6D8F40C369C2A55B" modified="2018-07-18" version="1">MSGPPSRIRSILGHLIPHQPTPPHIHHLSPTFFLERAASIEPNAEAIYHITSNGAILRRSYQEFADRARGLAYYLKKHDLKRVGILAPNTPAFLEAIYGIPAAGAVIVPANYRLKPDDIAYIFEFAEVDSIIVDAEFVHLLDAFKAKHPKVPLIVDLDTDATEGQLCGPFDEAVLEGLTYDRSNGNAGWAGLQSHATNEDDMIAIPFTSGTTSRPKGVVYTNRGAYLACMGNIIESGLNQGRCKYLWTLPMFHAMGWTLPWAVVAVRGLNVCLRKIDYPLIWKLLKELRITHFNAAPTVNTLLVASKEAEKLPHECRVTVAASPPSPHLFEQMTSLNLMPVHVYGMTETYGPLTKCYVLPEWDNLPPHEKFAKMARQGHGFITSLPIRIVKPDQPGGVLVDVEKNGKEIGEIVFFGNICAKEYYNDPEATRKLFEGGGLHSGDLAVWHPDGSAQILDRAKDIIISGGENISSVALESMLVEHPDILEAGVVSVPDSHWGERPKAYITVKEGKRLVGEDVIDWAKHQSNISKFMVPREVEIVDELPKTSTGKIKKNVLREWAKTGRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI44</accession>
    <name>A0A2T4CI44_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1322313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI44"/>
    <dbReference type="STRING" id="983965.A0A2T4CI44"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF804">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="186"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="334" mass="37133" checksum="FF8DEC34E6CAAAC7" modified="2018-07-18" version="1">MATDAAVSKDGLFIPLIDFSEFLNGTAATRQRTAEAILRGFQDAGFIYLKNHPIPQETVKHTFTMSANFFAQPAEKKAALEWTTPQANRGYVAHGREKVSLLQDNAEVEKVRSAVPDLKESLEIGRDDEQGHPNNWPSEEGAIVGFKADMLSFFEQCKALHVQVMRAIAMGMGFEEGFFDRFVDVGDNTLRLLHYPEVKSDVFNTPGQVRAGEHSDYGSITLLFQDYRGGLQVKSPSGTFVDATPIEGTIVVNAGDLLARWSNDTIKSTIHRVVEPPRKEGATYPSRYSIAYFCNPNFKDLIEALPGTYGTEQEKKYASINSGEYLVQRLTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIL1</accession>
    <name>A0A2T4CIL1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1396500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIL1"/>
    <dbReference type="STRING" id="983965.A0A2T4CIL1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="102" mass="11404" checksum="89A7CE716306CDE5" modified="2018-07-18" version="1">MPKAAAGKRGAKDGGKKRAKKDPNAPKRGLSAYMFFANEQRENVREENPGISFGQVGKLLGERWKALNDKQRAPYEAKAAADKKRYEDEKQAYNADQEEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIN0</accession>
    <name>A0A2T4CIN0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1435202</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIN0"/>
    <dbReference type="STRING" id="983965.A0A2T4CIN0"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
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        <location>
            <begin position="418"/>
            <end position="576"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
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            <end position="325"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="20">
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="575"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="298"/>
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            <begin position="342"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="579"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="PROSITE" id="PS50830"/>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="599" mass="68208" checksum="704E2F51337F62CA" modified="2018-07-18" version="1">MLLLDYQNALIQSVLTERFSGAPPVHIDQTVSDFDGVTFHISTPEVKTKILLSIQIRCFKDLAKYGAEQVLQREYGQYVVPVEVGYDFSVLVDLENLPESKEERDALAMQFALLKRHAMAAPFEQAYEEHYKLKEEASKFSSEDAPKGVMEGGEVKAIHYREEEAIYVKASHDRVTVIFSTIFREETDRVYGKVFIQEFVDARRRAIQNAPQVLFRNDPPLELQGVPGVQDTGSGEIGYVTFVLFPRHLTPARMPVVISHIQTFRDNFHYHIKASKAYIHSRMRKRTADFLQVLRRARPDNEERERKTASGRTFKRHSTQSPPKADLRVATTMVWPFGGSEPSKRAPEDDQPQKKRPISWPDTLSSNAEDAGPLAAAKAWAPMVGFSLVGLAALQLYANYLRRIPGAAYVRPNFFRNRSLFGRVTSVGDGDNFHLFHTPGGRAVGWGWLRKVPETRKELKGRTIPIRIAAIDAPEGAHFGKPAQPYAAEALQWLRNYILHRNVRAYIYKTDQYERIVATVYVRRFLLRKNVGLEMIKAGLATVYEAKSGGEYGGLEERYKAAEAKARRKRRGMWAGDPKAFESPREYKTRWAAQQDKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJG4</accession>
    <name>A0A2T4CJG4_TRILO</name>
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        <submittedName>
            <fullName evidence="5">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1427508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
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    </dbReference>
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        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
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        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
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        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF5">
        <property type="entry name" value="RCC DOMAIN-CONTAINING PROTEIN ATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="365" mass="38615" checksum="6828D01FE9B93C41" modified="2018-07-18" version="1">MDAVYAIGSNGSGQLGITHKEDVSVPKPAVFHPDQQAALPRIIKVAAGGNHTLLLTEAGKLYWSGDPTSGACGLRPFPNIPVFLEARLAKENEEAVGEIALVAATWEASVVVSRDEEDGKRTKVFSFGIGQKGELGLGELIVRTPSATRIKDFPPAGSEIVDLSACMGHVVAVLDNGEVYGWGNCRKAQIGEPAAVVFAPRKIEGIDFKAVRVVCAKEATCIFGEPGSGNIRVLGSDKWGLVSQAPSAAPAWKDVGASWGNFYILGQDGRLTAWGRDDHGQLPPPNLPPLERIAIGSEHVVALTVDGDVLSWGWGEHGNCGPKTDNNDVKGRWNVIASSKLIPPESKIDNIGAGCATSWICITSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJJ2</accession>
    <name>A0A2T4CJJ2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1323633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJJ2"/>
    <dbReference type="STRING" id="983965.A0A2T4CJJ2"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF23">
        <property type="entry name" value="JUVENILE HORMONE ACID O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="23125" checksum="29B12472DB732AD3" modified="2018-07-18" version="1">MTEVQTPQMYLAQARACGSVQDCMSLYDKWAATYNIEVGDKAQNYVAPEIVAQVAQRSSQDLAQYTILDAGCGTGLVGQALARAGANAIDGLDLSPAMLKIAKETGVYRNLYQADLTQRVQQPEGVYDLVTCVGTFTNGHVGPDPALREFVRLTKKGGTVIATILQEFWETAKFDVEVKKLAAEKVVEIVAQDVIDYVKGHGDKAVVVILRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJL4</accession>
    <name>A0A2T4CJL4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1022089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CJL4"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="3">
        <location>
            <begin position="117"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="5">
        <location>
            <begin position="245"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="4">
        <location>
            <begin position="698"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1353"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1412" mass="157988" checksum="8FA31161A15E0200" modified="2018-07-18" version="1">MLASSSSSQKGFAASSQPSQSLKQTDGAPIAGRTSIDREGTGLQIPNGGASRNLSASAVSFAPRASSSLNPGAGPGSFSSELRSQVVPIRQGSRTDAGPVYPSSFNDQLEEGDIVEQNLVLLRDKLKREMKIKEGSENMLEALNLKKAKQTKEQRQRVEAELTASHSRIKVLKQQITDAQATKAAPPSTPPRNRSQQDVPPHRSPHSLRSGPGSDIEEATENPTFTLAELLQALEVGGMTPDYYVTRANLLVDLFKRYPTLKYDLVWSVFGLRMQMMLLSESREVVAAGYRATRYAISDRNSLKKIRSLNTDYLVIRSLNNYRKADVEREQALKFVRAFLDVKDGVQEISRAVVRTIVAVAEYGDDRSGSAQPTEQNTDRLRPICIETLAEILVRDPRLLLASGGLGPLSEALAEGTYKAPESLTSAFLYLLDTPHRRKYIQPGYGLDVVFNSFTSQLAGSDIVLKQNCKAISVALRSWSGLMTLCMYDFRSIRSLVMSISLPNPAIRETILDLLFSLLRIKPPAWAVSFLAGRRLTTYGRVNNLNIKAETRDRGYLEEDTGEQNFVDHYTALILAVLIKSGIIQTLLQVARSESDTMLKRKTTLLIGETLKLAAKLLPPSWSAEIQLLPELFSAAAKFGDSQSYIASSIVYQMSSINRTLYRSAPTDTLAGFLPSSDSMNDLALLDDQRKAGSTVAFDDATFRQLLIDTGVLNSSNYSKWNWENILKVIDGPLQVGKRLEEAIKASKFMKRIMSFYRPFKYKFADVRNTRNAQKYVRAGCALVHSLLQSPEGVRFLADSKLLRQIAECLAQCDPTSGLTAQYPMFSKDRLTDTLCAGYFPMLGVLTGDPKGLAMLERWRMFNMMYHIYELTTRPDLIKLLLSSFDYSRQGHHRILLSKALTAGTKEIRIHATNTLRKCTLRRVPSIDGRGELSDSRWAIQLLVTQLYDPEIEVCSTAVKILEKACNRKAYLAYIVECRPALDHLGEIGAPLLLRFLSTSIGYHYLDGLDYISNEMDDWFLGRNDTYVGLIEASLAKAFLTDTDEHHHRLSVFDEHEAETDYHDSHIPPHFYRELTRTQEGCKLLSDKGHFEEFANTIREHGMQSEDPELITKVKGCLWAVGNVGSMELGAPFLESTDMVEQIIKIATSHEVMSLRGTAFFVLGLISRSTHGLEILSEHGWDANTTLMGNSLGYCIPSDLSKLFSLAPWHHETPASIRLPESQCTIKEQPPPRPARPPLELSEMPPLVNDVAISERILELIVDLGNTVLYRKAVTELQKIKARKPMAFRSAEFFKMVMGLMEWNHYRLGVRRMVIDLFEKTVMRQIVFDEEESDSSEEDESSQVEVEYSASSGEDRDDRTERQRSISEPTEPSPNLIPAPLRVRRSEDQAMRPPGFLAPGGLARDDDVLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK08</accession>
    <name>A0A2T4CK08_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1368400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK08"/>
    <dbReference type="STRING" id="983965.A0A2T4CK08"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="337" mass="38114" checksum="A5BA91B963CF4023" modified="2018-07-18" version="1">MSLPTRRLGTDGPLVTAIGFGAMGISAFYGSTEPDEQRLKVLDHLYETGERFWDTANVYGDSEELIGKWFERNPEKRKDIVLATKFGNRGPNTPNNDPEYARQCCEESLKRLKTDYIDLYYVHRVDSNTPIEKTIRGMVELKKKGWIRYLGLSEVSADTLRRAHAVHPIAAVQMEYSPFALEIEMPETNLLNTCKELGVAVVAYAPLGRGILTGQIKSPDDFEEGDFRRNIPRFSRENFPKTLELVTTLQEIAARHNATSAQLVLAWLLKQWDMVIPIPGTKKIKYYDENMGALRLTVSDEENDEIRRAIDKASIAGDRYPPGWAAGLFVTTVPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK72</accession>
    <name>A0A2T4CK72_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1027497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK72"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="91" mass="9880" checksum="B1F4DE083408B8A4" modified="2018-07-18" version="1">MVPIDRIGHVGRRSSAALPPRSESRSMTGANSHSHQPYSRMRVFIPREHKPKGESTGAFPRAPRASALNLALICVVGCSMALFFAKGSHHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPA4</accession>
    <name>A0A2T4BPA4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1154553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPA4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="95" mass="10285" checksum="299EC83692CA7AFF" modified="2018-07-18" version="1">MTSHHKPPRLGLGPFSAAHRQGKGKHRRRLLKKWTDFGPNLDALAGSRFRSLASLALPAGVFLTEGNRQLCRSSIRPPSHSGNSSPVASSWASDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ16</accession>
    <name>A0A2T4BQ16_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1386726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ16"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ16"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="94" mass="10300" checksum="CD6B8EB174018148" modified="2018-07-18" version="1">MAEELLDKLRDLVEGQIDFEGQRRAEVFATLLLALTGLIAFNVGYVLQDIVKCVYVGLGGTVLTFLVVIPPWPFYNKNPVKWLPAGSAFNTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ62</accession>
    <name>A0A2T4BQ62_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 76 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_213676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ62"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ62"/>
    <dbReference type="OrthoDB" id="4104179at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="597" mass="66178" checksum="B85D65AF422609F6" modified="2018-07-18" version="1">MLRELQSVAPQLVSSVRFLACSVIATSSADCRQTPADFLRIPTGNHTINNASTEILQYAYSALAVLQNDYYQVGRNTWPLAIDWTAAVTQTVVSGMLSTLTRSLDLIDPGVTPGIRQAQENLISSLYDQIIGYHYAQDIVAIKDEAFDDILWVVLGWIEAINFARLHGNLYFPEAQHEANTTYPTDIHAALTTLPWRGQFWIPSFQSRAQSFWLLGAQGWDTELCHGGMIWNPRLEPYKNAITNELYISASVAMYQHLLDESAVDKDPAYLQAAIEGYKWLVNSNMTNDAGLFVDGFHIGGLANGGIECNVRDEMVYTYNQGVLLTGQRGLWEATGSPSYLTDGHNLIQAVINATGWDLETNQPTDPVGTPSALPIWRGLGRGGILEDECDASGTCSQDSQTFKGIYFHHLNQFCRPLDGKGFQEHKSFNVKSFNSVRAAHRSACQAYLDWIEHNAVAALETRDEQGRFGMWWGAGLVGNSISVSPQSDGIDHDAANTTDYRNHGTPVDDTWGRTSRWLPGPQKGGLDKQVVARQLANKDEDTDMDVMQSMRKSSVQRKKRQSTDPNDRGRGRTVETQVGGLAVLRAYWDVSQSVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQM8</accession>
    <name>A0A2T4BQM8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1395519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQM8"/>
    <dbReference type="STRING" id="983965.A0A2T4BQM8"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="70"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="579" mass="63443" checksum="3A789A7774FE83FF" modified="2018-07-18" version="1">MSNKESGLVTPPEKGDNVVDYQTSTTVIPKEGLERDPNWLTRNGLNIDSFKKKHYGPGIVELERPMKARHLHMIAIGGSIGAGFFVGSGGALSKGLFENQGPGSLFVDFLIVGIMMFNVVYALGELAIMYPVSGSFYTYSARFIDPAWGFAMGWNYVLQWAAVLPLELTVCGITIGYWNDDISVAVWISVFLAAIIIINVFGALGYAEEEFWASCFKLGATVVFMIISVVLVCGGGPSDGRYNEYWGARYWYDPGAFKNGFKGFCSVFVTAAFSFSGTELVGLAAAESANPTRNMPGAIKQVFWRITVFYILGLFFVGLLIDSNDSSLLSSSAYSDSKASPFVLVGKYAGLKGFDHFMNLVILVSVLSIGVSGVYGGSRTLTALAQQGYAPKLFTYIDKSGRPLPSVVALILCGFIAYVSLSATGPVVFDWLLAISGLAALFTWGSVCLAHIRFRNAWKYHGHTLDEIPFKAAGGVYGSYLGLFLCVIVLIAQFYTAIIAGPDEPGMGTAESFFKQFLAAPVVLAFWIIGWLWKREPFLRTKDIDVDTGLREIDWDEVRRHREEVAAMPAWRRILHAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQP1</accession>
    <name>A0A2T4BQP1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1426398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQP1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQP1"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015672400" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="411"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="463"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="584" mass="63265" checksum="7CC478933CE87362" modified="2018-07-18" version="1">MRIESAAAHSPRLIPSLLVALALALPHALTVQAAALQEIVFQKEAPGHVGGVASESRECSAIGRDLLARGGNAVDALVGTTFCVGVIGMYHSGIGGGGFAVLRDANGEYEAIDFREAAPAAAFEDMYKHNVSASVRGGLAVGVPSEVKGLEYMHTKYGVLPWKTVMQGAIHVARNGFRVSSDLVRYMSNTVKGDGETFLTQDPNWATDFAPDGDLVKEGSWMTRKRYADTLETISEKGSEVFYTGELAKTIVDYVQQTGGSMTLDDMANYKVLSRPVHNVTYRGLTLHGIGSPAGGAVSLQILKILERYSQEDWWSDQDLSRHRLTEAMRFAYAARISLGDPAFVDGDVEGFEKEMLDPKNIDAIHERIWDNQTQATKYYNPHDFYVPENHGTSHIVAADKSGMAVSLTTTVNLLFGAQIVEPKTGIILNNEMNDFSIPGVSNEFGFAPSPANYIRPGKRPLSSITPIIAAFPNGTLYAAIGAAGGSRIISATAQVLWHVLDGHDTALAGALERPRLHDQLMPNTVLLEEMFDDEVAVGLERRGHNVTWVRPGLSSVQAVRRFTDGVFEAASEPRQKNSAGYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQV1</accession>
    <name>A0A2T4BQV1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_207994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQV1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="111" mass="12014" checksum="E515C2374AF3C349" modified="2018-07-18" version="1">MTSTTSHPQDLHHQEHPTNEAWKEEQAIAVEIPYVFSSVTGPEGGASASSRRETTPPSASSRRETTPPSASSRRERTPPSFSLPSYLRKTLPCTKAGNSLAGWLAGWLGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR01</accession>
    <name>A0A2T4BR01_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_61682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR01"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015716121" description="Glycogen debranching enzyme" evidence="1">
        <location>
            <begin position="21"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="82045" checksum="5765622D2293BCF0" modified="2018-07-18" version="1">MVRKILTSLLLLVSCGGVIPHSLHNNSSSCAARTLHLSDPPYQDHFYSDCHVDAQAVVTSPLPNSNLSIIGPRFIVAWPAGNSGICTLFQPQSGKNGSLAIELVNSTLGSPLGPVYRKSNQSAHPFVGVEGVLSFNDSAELPIAILGSVRNIRDFTEGPSLLSPVIQAGINVTKYQNNGAQITRRWLDNVTTTTFTLVPWKNSDSHVRIHNATLRFGSGFYHFTASFNYPQLKQLTPSQILNNQSQALVKEQPETVSSLSFFSYTEKLLAGGWRFLTYFGRDSMISALLLQPILSTGNGSAIEAVIGAALERVNRTDGSVCHEETIGDYATFVNLQNNITSTAAGFTYPMIDTDYYLPILMARYFASSPDRISPLLSTEAGTIDVTNANLTWGDLGYTTASKIMNLTAPFEHTQTVENLIALKPGQVVGQWRDSTYGLANGRIPFDVNCALAPAALYAISSLASMPGVYPNNSVTRDWATAAARRAKVWEDKTLQFFQHNVTTQTAVSRLKQYTSMNTFYKGPTNGDSVSEYSTNGTVIDYGLSINSTATPDIIPISHTDTAFRHYLLNTTDDEQLTTFINASANAILRPFPAGLSTPVGIVVANPALSDNEVLIANFTNSAYHGTVVWSWQLALMAKGLERQIERCRGVNSTDIPQSVTNATTIPKFCSNKGVFGALLKAYNKLWDIIEDNEEQLESEVWSWTYNDGSARGFDFSPLGVLPPPPGVGGGTESDVRQLWSLTFLAVKRNKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR15</accession>
    <name>A0A2T4BR15_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1140418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR15"/>
    <dbReference type="STRING" id="983965.A0A2T4BR15"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="761" mass="84976" checksum="62080CDDA6BB01DF" modified="2018-07-18" version="1">MSSSTSSTSARAERRKLRRGTTSCWECKRRKTRCHFEKSGSSACESCERRGCKCVLQHIEEPSSGTEAAGLSVRAGPAGDQLNHLEGLVDRLVGQSTLPTQNSPQKKQTSASFNHLPQRNRKLQPYSDSRRRLLPKPVHGPAQSSFNDNGEISEQPTQTVTPHLSSHTKAADALLLPPHPTNGALRCGSLTLLLQSILPSANVTTRIMHQNKLLMMSMHVFRGLSTDPFRSAAPGRISRLASATPTNVEPIDLARRLFQLAICLQQSDRTSEISALCLDRSNRDVAGQFFEAASRYVTSQDSLVVSSAGIETLMLEGLYHISAGEMRLAWLVFRRAIGIAHLMGLHLPQRRRHSKRTPICLATLWFRLIFTERYLALALCLPISVRDDSFMEDLVGLEPPEQLERLQAKLTSRIVSRNELMRLDPFATNLAYDHYNETKDIDHALKQAARCLSADWWAFPRLKDAQTNAKLKDMTSKVVLQLHHYNLVLLLHLPYIVPRLEDRSPGQGVQDNTNFKLSAMFAGRELLARCLIPVSPSRWSASTRGNTLKIVLAALALLLAHLDSHRLGRDNVLDHQRPSDLLMVERAIQGLDSMAQKYDDVLCFSAVQALKKLGNIEAMAAGGLGYKVWWEHSDVMHLECLVRDEEEALTLVFPYVGTIQVVRQCRQDDIPTNAVESSVITETTCFNDDLMTSWWAWRSPPSSFWPELTPMSPSPGDRQSTIPDGRGIHDSRDLSSSGIGRADMQTMPRLRLQDLQVSDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR21</accession>
    <name>A0A2T4BR21_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1395469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR21"/>
    <dbReference type="STRING" id="983965.A0A2T4BR21"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="484" mass="53496" checksum="74807E4E2E51B9F9" modified="2018-07-18" version="1">MSFQPTKLPSTTVPPASLKRDDVAREIPELLTLYDKFPHIIYTKSDPVYETISSAFNLSISTRPLVVIRPLEESHVQATVKIARATGMPLGIRSGGSEMSARNYRGVDKGIIIDMRSMCSVKVSDDKTSAKIGGGTIGGDLAVALSEQGLFTPIGWHPRLGYAGWSLAGGYGLYTSAYGLGLDHILGARLVLADGFAVDVDKDNHSDLFWALRGAGNGIWGVVTQLTIKIYPAPKLLIGTLQIQKGNWPAVLDRWANDIEPNLPQEMAGDLYFRNPTLNKPEMIIFFAWCAKEGDDLQKGWEYFDMMKSLPGALVQRIAESDFASYILSELTIQPASFQTRGVIAKGMTDKIAQVIINNWKDPSIYMGIPCHFIHGMATKPDPTACFPLRYRHRIFPISARHAELPRTAEKDAHVAEMCARVVEELRATGDCYVGAAYENLLPPIDTDLEATFGREALDKLRALKKKYDPDNFFSRGYPILLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR51</accession>
    <name>A0A2T4BR51_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_8733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR51"/>
    <dbReference type="STRING" id="983965.A0A2T4BR51"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="161" mass="17653" checksum="1379CE4900B86778" modified="2018-07-18" version="1">MQSWANNGSPIAIKAAGLSHDGASDVCEQSFPVESTSLRPMPQLASHPSADQDVIQRAQAIFQKQRPCARLLQADAGYHSSHVILYSESYVESLVVCDIRPKQPREGCTRFSSVDDDRMEGDMIDALKGGCLLEGQTVFLLCYSQWLLSSMQTVNFPATPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRA5</accession>
    <name>A0A2T4BRA5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIM-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1385801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRA5"/>
    <dbReference type="STRING" id="983965.A0A2T4BRA5"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="10"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="279" mass="29792" checksum="959CB9159FBB2B97" modified="2018-07-18" version="1">MAPPTDRDMILASLRARIAAGTALIGAGAGIGLSAKFIEAGGGDLIIIYNSGRFRMAGRGSLSGLMPYGDANGIVVEMANEVIPVVKKTPVIAGVCGTDPFRNIPAFLKQLRDLGFAGVQNFPTVGLIDGQFRANLEETGMGYDLEVDMIREARSLNMLTTPYVFNVDESRKMARAGADVLVAHMGLTTNGSIGAATGKTLDECVQLIQEIRDAAVEINPDVIVLCHGGPIALPKDVEYVLDRTRGVHGFYGASSMERLPVETAIEEITRSFKELKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRC2</accession>
    <name>A0A2T4BRC2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1451229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRC2"/>
    <dbReference type="STRING" id="983965.A0A2T4BRC2"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="401" mass="44300" checksum="4936542C7F9A5497" modified="2018-07-18" version="1">MIPTKNIDDITNLFKAIDNKQVDQISKIVAAGLVSPDAPNNQGETPLIAAVTSNDPAMIRTLVSLGATVNGYGLYCEDDSRTKAQRTPLQVAAAQGKLGIVKILRDLGADDSLVAPDGAIALRLAAENGHREVVEYLPARRGGAWKRWKTTHGKQMQRVRRILEKIGSVLKFFVWTVPKFLLWTIPKRVVTTVPKAVFVTLPKELYERRHKIGPWCKRQIYKFPSRVKKLANHAHDGIKKAGKVIEKTPGKIWEVMKRMPGALRLIMSWIGRGSCNIGNAAFDVLKRVVSLIHTTTEAVIGFFRAVTLADVANGFRAVLRAVFIDFPKAAAWLVTTVGKTAYQVLESVLGTLGKVIFYAVALLIRLVGWLPQKTWEMLLACGRSVGKGVEEVLVCINPKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS70</accession>
    <name>A0A2T4BS70_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1405909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS70"/>
    <dbReference type="STRING" id="983965.A0A2T4BS70"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="269" mass="29289" checksum="55614B47EF79A895" modified="2018-07-18" version="1">MHLFLIRHGETVDNVAGIYAGSRDSALTSHGVLQIRRLATHLAEDADSALEYIFSSDLQRAAKTAEAIAAEQKRVHSRDIPVVQLPELREKDFGSDEGIKFGDSRGRAPDSETPESMKARVDAFLDGYLLPLLSLQTEEASSRSRCAIVSHGIILGVLYRELCARVSRGGITVDPNPSAASSLISPPFWDNTGYLKCTVSMAEAMAGEDKSLPLRLHVSLVNCTIHLRDLKKTRGGIGSAAFDEKQRTLTSFFLPGPTKKRKSHDMSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSN3</accession>
    <name>A0A2T4BSN3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1384904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSN3"/>
    <dbReference type="STRING" id="983965.A0A2T4BSN3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="485" mass="53512" checksum="9B0B0D92604210E9" modified="2018-07-18" version="1">MAVISKPVIDITSYKGNIINGQFVPTAKTRHSIDPATEEPLPPVPLATKQDLDDAVKHAQEAFKTWSQTTFDHRAQLMLQYADAVEANRSDLERLNTMESGKPLLVSKTELDFTIRWLRAFATMQLHDEILEDDDERTVYGTYRPLGVCGAIVPWNWPVLLGLGKVGPALMTGNAVIMKPSPYAPYTDLKLCELAMAIFPPGVFQALSGDDALGPWMTEHPDISLITFTGSVRTGKLVAASCAKTLKRCILELGGNDALVVCEDVDIAKCLPKIATMTFINSGQICMLAKRIYVHEAIYDEFKAALVEFTKEHVKTGGGFEPGVLVGPIQNKMQFDLVKDMYQDVKASGYQLALDGRILDSEKGYFAEPTIVDNPPDASRIVVEEPFGPIVPLLKWSSDDEVVGRANSLNHGLGASVWCRDLVRAERLARRLSAGSVWVNSHFDVAPNVPFGGTKESGIGREWGMEGFKQFTDHVSLWVWKKVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSS5</accession>
    <name>A0A2T4BSS5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1385007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSS5"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="513" mass="56827" checksum="79CF4249629E7A5F" modified="2018-07-18" version="1">MRFFKTTTDTAQEPEVEVDLAGKAGHVEKNPLPVHNEDAVHRPSIDRQLERRVVRKLDMNLVPLVMALYLLAFLDRSNIGNARIAGMSDDLNLIGDRYDWLLTIFYIPYIVFEFLGIMWKVVPPHIWATFVVFLWGLVSTLQAVIQSWGGEMALRFVMGAAEAAYGPGIPFLLSFFYLRHELGSRCGVFLSAAPLANTFAGALAYGITSGHPSIAKWRVLFLVEGLPTIVMAAVAFFYLPDSPEKAKFLDEDEKRVAMARSVRQAGTSRRIGGVDWKDFGRGLIDIKAWFTGLMYFSCNVSFASLPVFLPTILSEMGFSDVTAQGLTAPPFFLSFLVTLVTPYIADRTQQRGLMLIFLTIIGGVGYVILATAKSVGARYFGVFMAAGGIFPSIANILPWVLNNQGSDTRRGAGIVLLNVIGQCGPLLGTRLYPSNEGPFYVKGQSICAAFMFFTTLLVIGLRTLLVWENKQLDKKYGTIEQQKTRLTEAEGRGEEADQVVAVENYGPMFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSV4</accession>
    <name>A0A2T4BSV4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1384987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSV4"/>
    <dbReference type="STRING" id="983965.A0A2T4BSV4"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="540" mass="60307" checksum="1030C76AB42CDFF5" modified="2018-07-18" version="1">MVEVTRERTLQDIENELDIKIYPGTEVMVDVGTHHFIKSGSGDGEARVLVPQPSDDPQDPLNWTYFWKLTTIICAGFVSISQNLGPLANAPLFGLYVEEWNISLADAVQTTAVTILILGFSNLFWIPISTCFGRRPALIFSTLVCTISSIWRVRATSYRSFLGAAALNGFGAGPCESLMPQIIADIIFLHDRGKYQTLYFAIYFGSLSIGPVIAGSMAERFGWRSFWWFNTGLLIFTLVLNIALLPETRFARKTHPRSESSPSVDEPETKSSSVIDHSEDASQQPQDPWLSRGHPSMKQFTPWGSYQGSILQELWLPWYLHAFPIVEFAAFIVSFSASGFLVANLTQQQYFGAPPYSFTTQEVGFTNFAIFAGSMIGLLTSGPLSDWVANYFTKRNRGIREPEMRLITMLPYTLGMIIGLVVVGVGYTQQWSWKVIVIIGYTLLGMQVTSLPSIASTYAVDSYKPATGAIFIAITINKNVWGYGVGKFITPWTMEAGYLVPIMTLMTLITFFCSFGIVFWYCGKYFRGLTKNSFLHQLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT19</accession>
    <name>A0A2T4BT19_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1405417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT19"/>
    <dbReference type="STRING" id="983965.A0A2T4BT19"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015367442" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="380"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="540" mass="57305" checksum="7421C2C00A5FD941" modified="2018-07-18" version="1">MSLSKLSVSLLALAGSAIAGDLPSITAKGSKFFYPNGTQFFIKGVAYQQDVGQAGSTDSSTSTFIDPLSSEANCKRDVPLLKQLGTNVIRTYAIDPKADHSACMKLLNDAGIYVFSDLGEPSLSINRDTPAWNTELFDRYKAVVDEMSQYPNVIGYFAGNEVSNAKNNTGASAYVKAAVRDTKAYIKSKKYRWQGVGYAANDDVDIRAEIADYFNCGEQDEAIDFWGYNIYSWCGQSSMQKSGYDEQTTFFSNYSVPVFFAEYGCNLPSGAAARIFQETAALYSDEMTKVFSGGIVYMYFQEDNDYGLVKVNNGAVSKLKDFSALQTQVTKADPKGVDADDYKPTNKPASCPALTKDWQAINSLPPTPDSSLCSCMQSSLSCVHSDDLSPKDFGDIFGFICGKSPEVCAGINGDPSTGVYGAYSMCEDAAKLDYVLDAYYQSQKKASTACDFNGQAQVVSPKAASTCSAALASASAINKQAATATAPVGAGSTSGSKGAATSTNAAVAGRPSAQLLSMGEISVALYMGVAMLAGGAMIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT59</accession>
    <name>A0A2T4BT59_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1090198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT59"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="122" mass="13412" checksum="A7373B1AD2F324C6" modified="2018-07-18" version="1">MLRTTARATSRAGRPQGKRHENEREKKKKAECRRLGARSRVAVFSLVPTGTTTAGYVRPGRKGEIPCSPPRILVQVGNLCGGIVPLRLGVAVLRECYRHRITRTRTYILHASAGDYGDGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT85</accession>
    <name>A0A2T4BT85_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1384567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT85"/>
    <dbReference type="OrthoDB" id="4194555at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="772" mass="86605" checksum="9F5947FEB5DB4AE3" modified="2018-07-18" version="1">MAQLPVEIFELITRYLTRAEIQTLRLVCREFEAKVSAQYFRNVVVPFRSELYTSLDRDENTVIASRLFSNGMRIFESFGPHILRFALSLELDEFTLAYPPVKPAQEAVPAFWGIYRWPHATYHRYRDLEGLEQTADETDSMKKALRCLTKVTNLGLCCDAGLGFLVGPDQAVRKMNNPDPVFNTSNFRQEARSDRGDAVTTVADFNGVPRELTSATAQHDNFKRRVLEKMIADAGFAGFYIHEAIDLLLETEGVSLSNIDFDEREVLVAQPAPAMVQSPPHRQRRAENQVPRDSMSDPSTSRQPLIPTNLTRAQKELLLELEWAHRAMIQSYVISIIDNARDGCFSNLTNITIAKIPSAHVHILCRKELWESIPRVKNVSLAVIADWRRISKTSPGVVADTHVSPLDAVSKVYNLLNRYIGQQQNIETLHFEWICGGEFARGPYQRNQYILPAPFVDSPELMSSVDGAKDPERLLDLPYVKEFSLKNCWASPHVLTQIIRNMALQSLEKLEFESVSLSGPPVFAPQPVNVAQAADDAGLPLPPIFPGGVAPMIAGPVGEPAAAMFPQPAPAPPQPSDDQQSDRLVLPEPFSWAGFCEHFSPGIKMRMLPRFRELADGAVRPEDLTLPLEKDLAPFLPNADQLAADEAQYNLSSITFKSCGYVYLDVRNLDVRALLPAEGQAAHSFVNSLRHDIFHSMQYCKDKLLGRILPYILPSEWKTLETVFLMERGWANLYSTRMSDDAIADGFEYPGTGRFSGTVERLDDAQDIEMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTA1</accession>
    <name>A0A2T4BTA1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1405478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTA1"/>
    <dbReference type="STRING" id="983965.A0A2T4BTA1"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="228" mass="24464" checksum="3F09E2E788AAEED7" modified="2018-07-18" version="1">MADYTALKVPELKKLLAEKKLPQTGNKADLIARLQEDDKKNTASAPEADKPAPAAAAVRKDEPKPAEEETGDKPAAAEEAPEATAPAPSFAMGLSSTTADEELKKRAERAKRFGTELDDETKKLAERAKRFGIDDKEVAAGLDSALPERPLKRGRGRNEGDGSGRPDKRRGGGQDRREPSGNERRSARNRGGRDQGGKASGKPKFGSVIEDPVERAKAEKRAARFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU85</accession>
    <name>A0A2T4BU85_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1405326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU85"/>
    <dbReference type="STRING" id="983965.A0A2T4BU85"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB72867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="57817" checksum="5BED691E88EDB2D8" modified="2018-07-18" version="1">MLVTYKNNRLIPALIIAVCFALFYCLIDPSLENYGYDPEAMHKGIVVEEVQMSDGQRKLVELDKTPKTEAPELPAKEVQYVAPTNSHKTSDEDQTPSKAISYNGLSTDDVLLIVKTGGTTVWKRMLVHLTTSLAHHRIPLANIAIYSDVSEQIGPYKIIDVLANMSSTAKAQPDFDVYRQQPEYTAHNYYVEAAGVNGDDWGPVGGWIIDKYKFLPLMQHAGDNWPKAKWYIYMEDDAYIFLPGVLGYLAKFDWTQPHYLGSYAAKSDVIFAHGGAGFALSRGAWEQSFGKQGNGNGSLTEEYYQYTADHCCGDQVLAHALRKHGIKFGENGGDGKFTFGFNPLVHWAFAFASANWCSPLLSWHKVHNRDVARYYELEQSWDWSKGPLLHRDFFNAMILPSIKQHAEWWDNYSGVFEVSSGNREWAPKPGADNGKFDEALWSNAWESVQACEAACQGWTKCMQWNYVEDLCKMDDKMYMGQGYAPGMSQRKTALKHTSGWMWQRLDEWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUA5</accession>
    <name>A0A2T4BUA5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1465483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUA5"/>
    <dbReference type="STRING" id="983965.A0A2T4BUA5"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="757"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1188" mass="131624" checksum="49DAD0C638AC932E" modified="2018-07-18" version="1">MADFRQLALDFVLEEDEAKLTELAQRAAKELEAAPANSNPVARWVEAVQPWMPGNNETEDSQETPDWTSRAKALEFLSRTLDFVKPDLLKPSQVKLLIAFFGAMLDIDHKAGILASASALSRIIEMKAFQSQSGYDIISKVCGMKEDFQRQTAKTRLAVYELLRSLMTTPEVASNLQQRDGASSGFMMNLLELCRNERDPDCLIVWFDILRIFFQQYEPSQEVLEAVFAAFKAYYPITLPRLTQSGITPEDLKSQLRKCFSSTYRLAPLALPFLVGKLDQGDGVTVNVKVDVLKSIKECLEEYTHPEQSIIPYVSRIWGSLKYEVRNGEIEDAIWATLEVLKTLATRLKDDDLRNYTLDVTRDCVNDLSNPMYTTQAGRLIVSVLSANPSAFVLMVAPTVTHIKDNLRHRKSITHSQDLLKILNVILETRLLLSQTQMTDDQKSDFVAVDGVFKNLYNDVYKGPVALGSNVNANEDDLKIATEAVQGAGALISQRTVPLGPENDGGLLLPEETCSEICQALFAIPLSAFNNHSNSNLDDLLNETAKALHRAIQAYTPGFRPLVDQFVSVVRSSRDDQSDEAAEKIQKIASLLAYVGCSELPKSLVNGRHNFLVLIHVFTTELTAAIDAKASPKIWCALVVGIQAASRYFNDACLKHNPETDQAFDGTMWLYRATYRYPELRSLAGEDDDGSAPSYSSATPPKETTATELRNDFLLIGLVVVRSLYRRATAAVGPIHGTQKPALQLSGDFDGSDKPSEYQYLHLISDFAGFVLREMGEAQQVSLRLDHYFVNLFQDELIPVPASTSEEQRKARLEKYTDEQGSSWGWLTEKSVNILSLGLLEAMRPSVVAKLFDSGVAQELLISGTLSASLNQSSLTRPVTRSILTILANKYKIEGISYLMPRLEGRLDTALQNAQNAADSDDAARYLEQVSSVYAIVSGLIRRPSGTQARALIQRLREAPRNETTGHLLARRLEMLVAPQKCLTKESFAIVKPLWTQKIYFELVKPMLDTATAQDPEAGSPLIKTNYRVAVLAMVKHMPFAIWEDDSAAILRAAISLSQNLGPGPDTLPALEVLKRVLAEAPATAQEYVKSLIGLALPCFSAKAAAQLTRSEWLPAGYVPARTSPEVGAECGRLALEVVGALPRLFESRFVVPFVPQVRRELSLACGHAVRDLRRLARMARAAWTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUG4</accession>
    <name>A0A2T4BUG4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_7957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUG4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUG4"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="263"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="646" mass="67829" checksum="D12DF9BE3E7BFA91" modified="2018-07-18" version="1">MSGSDSVPATPDSVADGTRELAMQASPYSEDSSVAGTPNGDEVGDSPKRLPSLNTIADPRNMHPSSTALGILGKARRPSQTATSSFAGGAGAMENSVMAKARALHQQRMQKGMAASGSSPVSPMPSPGGAGVAGFPNLRMPPAMQRPGAVPHPRSAPVIPKPSLSERRANMGMGMKLSDIGGGGNASPTGGLRRPGAPSLAGSAANGPGAPNGKPSLGSQLDDFKKYIDAEKGWITFDGAATITRTGVEFTNGQTFSISLDEVEILDELGKGNYGTVYKVKHAKPAVPRFGQGLSGPKLAPHPHRSQSDSAVLDAASLDGRTGKIMAMKEIRLELDDAKFTTILKELVILHECVSPYIIDFYGAFFQEGAVYMCIEYMDGGSIDKLYAGGIPENVLRKITFSAIMGLKSLKDEHNIIHRDVKPTNILANTRGQIKICDFGVSGNLVASIAKTNIGCQSYMAPERISGGAMAPGTADGTYSVQSDVWSLGLTIIECAMGQYPYPPEASSTIFSQLNAIVEGEPPAMPEEGYSDLAKDFVKSCLHKIPKMRPTYAALLKHPWIQSLSKPETIDEVAEEGDAADKVAEAVGHMDLSSGTEDAEVAEWVKSVLQKIADGQNGDGPTKPALHAAPLDSVSPLASPILHQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUN9</accession>
    <name>A0A2T4BUN9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1472329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUN9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUN9"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="24781" checksum="CCDC90417237DADF" modified="2018-07-18" version="1">MDARKRRATTKPTSPDSQPHQRSSSSSTTTTTIPSSAPKSSKAEMEALNLSSSRASWRQHWMFFAVASGACAAFNGVFAKLTTTELTSNLSTAIAKSLSLQSHSSIIFFILNLTFNGIMWSLFTTALAKGKSATQVSIMNTSTNFLVTAFTGLVIFSEALPPMWWAGASLLVAGSVIAGRKDEGEGDAGDGAEGDGAVPVPVPLGSGGVLELDEDLVAGERYRDEDVPDLGELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUS8</accession>
    <name>A0A2T4BUS8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">M440DRAFT_1425050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUS8"/>
    <dbReference type="STRING" id="983965.A0A2T4BUS8"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000034">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="222"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="401"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="452"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="556"/>
            <end position="557"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="562"/>
            <end position="566"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="630" mass="70827" checksum="5E14764D426CF9DD" modified="2018-07-18" version="1">MASRERSVLVLYGSETGNAQDLAEELGRLCQRLHFESHVDELDATDLNALLQHQLVIFVISTTGQGDMPHNSLVFWKKLLRKKLPPNCLSRLKYTCFGLGDSTYLKFNWAARKLVRRLDQLGAATFIDPYEADEQFPDGIDGSFVRWAEDLKKHLLEHYPPPSGLEPIPDDTILPPRWSLAPALDPILKKIQELDLSSLRISHTNGAPTVPNLPPDGLLPIPAGWTATLTKNERLTPQEHWQDVRLVSFDIPALPSGHRLRPVPGDCLTLYPKNFPNDVQKLIDLMEWNNIADSPLDLTTCKSLPRNLYSPESCTLRDLLLNNIDITAIPRRSFLKNMSYFTSDEYHRQRLLEFNMPEYIDEYFDYATRSRRSIIEVLDEFTSVKIPAERLLDVFPLIRGRDFSIANGGATVTQAASSQDDAAAAAAATTTRVDLLVAMVKYRTVLRKPREGLCSRYLASLAPGSTLRVSHKPVLSPIHGAANAQRPLVAMATGTGVAPVRCLVHERLTHPSPAPMVIFFGNRNRAADFFFEDEWRALAQDAATKGSELLVFTAFSRDQRDKVYVQDLVRREAARLEKLIPQRAIFAVCGGSTKMADACKRAVFDPFTESGDEVVRKEMLAGITWWQEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUV4</accession>
    <name>A0A2T4BUV4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1340778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUV4"/>
    <dbReference type="OrthoDB" id="4492972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="271" mass="29291" checksum="8E76B5DB8B4CE88C" modified="2018-07-18" version="1">MIRQLFSRLTSILLHPMALLNPLYAFVVPFLLVTTIPLAIFAGITTTFAFSILILRVFVVYLDIALSLVSQSLSHLTESSAAKFHHPRRPSSSSPSSSSSVHSRTNSVSPSASSTLLKRQHNSRRRRLSSSVYSAGSATPASDIGLGLIPSVGAERDFEGIGGWRLGDDDDDDEEHLWTTINSRCELPDRLHDRNHRRSLSGGPAGAAADGGFLMMKGRARSPEQRLVTPASPNSSKARAPSAPRLMGGSNQNDGFFPVITTSKATKRNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV34</accession>
    <name>A0A2T4BV34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1340603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV34"/>
    <dbReference type="OrthoDB" id="4741350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="223" mass="26575" checksum="56601C662894D10F" modified="2018-07-18" version="1">MAKRWFVETTPEGRQQFVSIKRSRSYGGHHNRVREIDYIKVSLEEWNALVENERRLEEINKSVVDEVNRLKSTAATAQAEAKRLTVVVVPGLEKQIGVLTIENEALRRSIEKSVGDSSSRHHREEERLRFKITKLEADNLELREENAGLREKNRSLSKTLEQSFSRRVSELLGDVEFWKHQYKHWRSRYDELLKRYNDIFDLMETRTRKMKAYEDILRRNDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVB5</accession>
    <name>A0A2T4BVB5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUC173-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1362504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVB5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVB5"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="345"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="881"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="979"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1086"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1151" mass="126112" checksum="855E801CE4C8B53D" modified="2018-07-18" version="1">MATPTPTLAEKLDKIKSPGLQSQQKTVVVLQAVESTLKEQNTPPTPTGYFAALLALLQQAENNGSVNIELATPVVYLLDVVTPFAPQALLRSKFTQILTLLAPVLLAQDAEPILLRTSIGCLESLLLAQDLASWELSVTQIGPRRAVAGLLNLALDQRPKVRRRAQDALKKVLKNPPPSPSLDHPAADMCAHTALKNLEDLAAQAVQARKGKKAPSTTHDPALIHALQLIKTVASASGGWPSTKIESLCELLLNIAKTGNEYMTMAAFEIFELIFEGMTDELTSAKLPRLMEIISELRPAANDTQLVPPWLAILSRGYDVSAQVEPDETFQNLPELFTMVAQFLQSDSENIRISASECLVSFMANCIPPRVIVEPSIYDEKVLGKIAKAAESLLSVQYQAAWLQTFNVLEAIFTSLRWRANPIMLNVTRTIGEIRENPSFRNKKEADEVLGQAVRAMGPEAVLSILPLNILKPVKGQAGRAWLFPILRDYTSNTNLAHFKKEMVPLSEVMFQKVLDHGEAEKTMEIKIYETLVQQIWSTLPGYCDLPLDLMESFDQAFAEILANLLYKQVDLRLDICRALRTLIESNQAIANIEEEEDDLLLQSRVTKDAARKNLAYLGQFAGNMLAVLFNVYTQTLPQSRGPILQTVNAFLSITPNQELMATFDRVSQMLAGELQNAPAPEKKPQGQKSQDHMPSTAQTLMDLVITMSAYLPRESFAALFEIATVIINREEEPQLQKKAYKLIPRLATSELGKSTPHMISASVTAISRLLYEFRSSLSDQTLSDLVQTMDLFLTSNNREIVKSCLGFVKVCVISLPVELMMPRLDTLVPNLIIWSNEHKGHFKAKVKHILERMVRRFGFDAINKSCPESDRKLLANIRKTKERAKRKKDASKGAHDDDDASDDEEADGKRQYENEYDRALYSSDSDDSGASDDDDEAAQKPRRKAQKGGKTYIVEDDDEPLDLLDKKALARISSTKPVKQRKPQRTKAKMDLDGKLILGKDSDDEDNGAMDVDQPGRGGEDSGVGAYVAAIKGRDAGKRGRGGKLKFSNRRSKDGDDGDEMDDDTAVAVKNAISPGGRDPRAGRGRGGNGRGGPMRGGRGGGGRGGNSFGGGARSGKGGIAAGRRGLGSEKRHGPPMGAGVGKGKRGGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVC3</accession>
    <name>A0A2T4BVC3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1340234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVC3"/>
    <dbReference type="STRING" id="983965.A0A2T4BVC3"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="524" mass="56997" checksum="39F883ECC035F6FA" modified="2018-07-18" version="1">MDARGSKVVDRSKLAGKGDAAERDKDRQARGLGTAAAAATATPTGGVGKNTKKRRKVNHACVYCRRSHMTCDLERPCTRCIKRNIGHLCHDEPREADPKKKTSTGKTSTASVEDSDTMSQSDLGHSSISSAMGPPPTFDGARQRTNSGLGAGGVLAQANPLSLVQPDASSGLQANALNNNGNANQFAGFSDAWLTAQNYNDMNTYNPNYMIGPDVTHEFNLLNDFLHNSILDEGGVEAQQNAAFNRPGGPSEMLSGYGNGGGGGSGSGNGLPGASIAAGHAPGPMLPPPNTDSKALARSDKEKTREYYLQAADPSGNDNPEERMSRVLKAKYDAGLLKPFNYINGYARLGKYLDGHIASTSKQKILRTINQFRPKFREKAQGLTDMQLVYVEMWFEKQLMDYDRVFASMAVPACCWRRTGEIFRGNKEMAELINVPVDRLRDGKIALHEILTEESMVRYWEEFGTIAFDPAHDTLLTACSLKNPSDSSDHPIVKCCFSFTIRRDEHKLPALIVGNFLPHDPPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVL4</accession>
    <name>A0A2T4BVL4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Catalase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1404373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVL4"/>
    <dbReference type="STRING" id="983965.A0A2T4BVL4"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="9">
        <location>
            <begin position="10"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="491" mass="55634" checksum="C005353178424316" modified="2018-07-18" version="1">MATSEKPVVTLANGQPSSGPGAVRQIRYGDTNGGLVVLSDTQTIEVLAHFARERIPERSVHAKAAGAFGEFEVLEDISDLTDADFLTGIGKKTKLLCRISTVGGEKGSSDTVRDVRGWATKFYTQEGIQDFVFNDLPVFFIRDPIKFPSMNRSHKRHPQTNVPDNSMFWDFHKNNPEGIHALMHLFGPRGIPASLRNINGFGVHTYTLNKSDGSYVYVKWHFKPEDGIKTMDSKTAVRLAGEEPDYHVKDLFYAIQRGDYPTWSVCVQVMKPEEVESAPIDIFDCTYTWPYEKYPLRRIGRLTLNKNPDNYFQDIEQACFSPSNMVPGVGPSADPVLQARMFSYPDAQRYRVGPNYFQLPPNRPINKVYAPYVRDGPGTMNGNYGSDPDYVFSQLRPVAQSKRVTMPTHEHWQGRVIPFSTSFSDKDYEQARKLWEIMCREKDGKEQLLHNIVPTLVDIPESLRKEVLDYFGQVDQTLKQCLEGGLAKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW14</accession>
    <name>A0A2T4BW14_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1404507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW14"/>
    <dbReference type="STRING" id="983965.A0A2T4BW14"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="364" mass="39805" checksum="8735F4DF81D66196" modified="2018-07-18" version="1">MAEQTKSLEAKCLCGSVHFTVDVPVASLPLGVNICHCSICRYATGAPCMFRTQEQSLKPKFVAPSSDKSLTSYAVKGADCTYDFCSTCGCHIAGVSLDREGWTFSTSVFQDHGPDNFRLKTHVFSDSAKDKGLAKVLTHYAGVELPDWNPPKDDPRAKIVEAEPEVGADGQERLRAQCHCGGVSFTIRRPTQEIREHALLRNAVSPVDPSKWMASFDVCDDCRLSNGTHLVGWAFLPLSYCEPEIKSGDDDGLRIGTLRAYASSPGVQRCFCGTCGATVFYGCDERKLPGPGNWQVVDLATGILRAPEGSMADEWLTWRSRLAWADSGRRYDALFCSGLEQGMKKFVVAKSGRELDMDISFGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW40</accession>
    <name>A0A2T4BW40_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1433055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BW40"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="635" mass="71206" checksum="659150611C05E71E" modified="2018-07-18" version="1">MASSGRSSRWDGLPDEIVLQILSYLDPLHITRLQLVSRKLQKLCLDDELWKRRCFEESPWYQYLKNRRRLSSESEGEHRDGAALQSPEANGNTDGDGPKATPVGVKGKAGPGKTRRRYHRWQEIQDMANWDPTFPNERVSWYSEYIQRNGPACVNWLQTPRIRDRGYEAMMEARGLELYYPYDGNDGIGAMLAVSPLDDGSVCLWDVKGTRGKAGSLLATSKSDILFIDGPGSQNTRRSKRVDTGVTECVSVDNQRHRAYFAVQSHLIEIDLERLEVVSRESFEWSITALSKIQNDVPLTVGTSLGIHLHDFRSRARATHTAVERVDQNDIFKSIFDPTPLLPYAPLSQPTPVSIIHLPLRGSPDLVSNDIYVAGRFSNILHYDRRKFPVILDSIYSGATINSMAAMPHPFSSLDSEVRRHAELSTEQVIRSKGDGEGWTLIAGGTYKSKGSLEIFGLSQTAADPAGREMMQTSTMKNRQTAASAAILSVANHGTKIVFSDGAGSIKWFERDGLTECRRLRIGHCEGDEAPSLFASMSAAGELARKIVSTKSREGPDRPNDDNILFWTGERLGLVSFTPTPLYQYRDFEEDERDPAAEAEEEERRRVAEQMREALERQADEVRFMQTFGQGVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX94</accession>
    <name>A0A2T4BX94_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX94"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="70" mass="7639" checksum="E7C781717383C408" modified="2018-07-18" version="1">MSTSNTPEKTANPPANAEAKALPLTQAPAHSSLWLMGFCRHHAGASNRQSVCLSTAHVPLHQNLRLQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXR8</accession>
    <name>A0A2T4BXR8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF382-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1423932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXR8"/>
    <dbReference type="STRING" id="983965.A0A2T4BXR8"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="285"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="604" mass="67292" checksum="44424AB4ED819270" modified="2018-07-18" version="1">MAAPKMTKNQMRRAKKKEQKKAKGDNQKPDQTDEPTADKSDESPQPINGNDEKSAADSAKPSATVTVEPIQEDLLDDDPAFAAYRDVFNKFGLSFAEDQIAKEANAGNQGDVFFGDNDDIPDEEDENPSQPKLSKKKRKQMNKLTVAQLKAMVNIPEVVEWQDVSSSDPRLLVQIKAQRNVVPVPSHWAMKREYLSSKRGIEKSAFRLPKFIADTGIAEMRDAVLEKQAEQSLKQKQRERVQPKMGKLDIDYQKLYDAFFRFQTKPELTRFGEVYYEGKESEVDYQHFRPGELSDATKEALGMPPGAPPPWLINQQRFGTPPSYPTLRIPGLNAPPPPGGSWGFHPGGWGKPPVDEFNRPLYGGDVFGLTAPNGAGQAQLTQPQAANGDAVERTLWGELQPREEESEEEEEESEEEEEEDDEVPGGTEDVSGLETPGGYTSTVQPDYSQQGVETSIAGEMDLRKQRRGYETDESSAPRSAYTVVPERQVRAEGFFGSDRAYDISAAQRAAASGIPVLGADDDSRKRKKPGDVDIAIDVDSLSQQGGLSKDDLRSKYEASNKAEGIGAKWAYDDDLSQMIAEESRKRQRTEKELNEKKRESKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXV0</accession>
    <name>A0A2T4BXV0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1361227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXV0"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015444162" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44311" checksum="2653E53DCA6EA776" modified="2018-07-18" version="1">MQTIRLLAALLAASFSHAAPIEFDDEKIFVVSQKPSLALPYAPQAKSATLLANVTDPDLSRDSCGSVKMGNRTLWTCRDTSIRIPDTDQYGFVFANSVSWTDTRQDGAPDIQSGGPVGAGSDGTNSILLMKGPRPTLPTFYPLGSNMCPKSGICADGTTRWTGWPDSPPMITNTTEDGTTTAYTWVSSNHISTTTLELLTPQPSTTLYKMTYTPDTDPDVLPAVTAVDEAFWEEHEIGYGTYGNVVQGGYAYLYGLLKPGGVALARVPVESVEDKSKYEYYTGGNWITTKPAIDDKTAAVPNAGTTGQGTFYYSERAQSYVWIGQASPSIWADFYVTTAPSAEGPWTTPYLLYSGPNGDGELPSYSLQAHPHLLREYDDGIYLTWTQYFKASTYTAYITPLVYVSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY39</accession>
    <name>A0A2T4BY39_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1424028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY39"/>
    <dbReference type="STRING" id="983965.A0A2T4BY39"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="424" mass="47968" checksum="C3FEBE37C2F3093F" modified="2018-07-18" version="1">MHAQAADGRGSNIDELDRSLDEANTNLRALLDLTQSALTTIPQPLRSHDFPDDNRRNKRRKLDADRLGSSGVKPFRYGRYGQVEPGQLRMEIVSCDGGMFSNQSSYAAENILKDDNSVYCTKGNRCNIVLQHQGGSVFTLQELVIKAPCATNFSHPVREGMIFVTMHQDDMLSRTAQYQIQYAPSSRQRSRNADGDNALVLEREPRHIVSIQHHVDGTTSTRTRRSYVYRPDDDESRLPEMPEEFNRETSDFRVTTECSDEEDDDDDGYGGSRFHHTPNRIGSLPFENVDSDADDIVMPFSPQDTSDDLLLHHSRRHNIIHRQRDEDDEHTPSFSLSEAMDAHANATQEAVRAVGGRLLAPHARFYIEKKKSKCTIKFDPPVSGRFILLKMWSSSHDSGSNIDVQSVITRGFAGPRYFPSVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY42</accession>
    <name>A0A2T4BY42_TRILO</name>
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        <submittedName>
            <fullName evidence="3">Upstream activation factor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1403562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY42"/>
    <dbReference type="STRING" id="983965.A0A2T4BY42"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="182"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="416" mass="47835" checksum="323433D50318FB09" modified="2018-07-18" version="1">MGFTKPPVQALKVANKQKRKQLFVAHKKASNKERHEERHRRRREENKNPELKAARLAKNVPRTLEHKRVWDDVDDDSLGAVVDLEQLKRRRIEQAEAEERAAVEAAEKMEQDEDDDDDDNDSMLDSDEEDDEAKEARLERQREKRAQRVPSIAPSTTSTNLDLTPTSLALKFPALFTDEPPPEPKILVTTSLNSTIHDEAQLICTLFPNANYIPRSSHRYGYKYSLREICKFSAARGYTAVVLVKEDQKVPTGLSIVHLPKGPTFHFSISNWIEGRKLPGHGNPTNHYPELLLNNFKTPLGLLTAKLFQTMFPPRPEFEGRQVVALHNQRDYIFVRRFRYAFRDKRPTEKSVTDAEGKPLQGVEAIRAGLQELGPRFTLKLRRVDKGVGRAGSEGEDAIQWEWKSKMEKDRKRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY78</accession>
    <name>A0A2T4BY78_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1424079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY78"/>
    <dbReference type="STRING" id="983965.A0A2T4BY78"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="467" mass="52051" checksum="47D7FC730CC979B0" modified="2018-07-18" version="1">MAEKKADAPAAGMLWGGRFTGAIDPLMHKYNASIRYDKALYKEDILGSIAFARANSKAGIITEDEFQAIERGLLQVMEEWKQGTFVIMPNDEDIHTANERRLGEVIGKDTAGKLHTGRSRNEQVVCDMRMWLRDRIKEVDSKLVAFLKVVVARAESEIDYLMPGYTHSQRAQPVRWAHWLMAHAAAFKQDLERLRQVYERVNLSPLGCGALAGNVFGIDRYAIAEELGFSGITSNSMNTSADRDFIIEFLTWNSFFTNHISRWAEDLIVYGTSEFGFVRLADAYSTGSSLMPNKKNSDSLELLRGKSGRAFGQMAGLMMTMKGLPYCYAKDSQESWEPMLDSVEFVLDSLGIANGVIATLTVRPERMRAALDMTMLATDVAEWLVKKGVPFREAHHISGRIVALSENTEVSMDQLTLEQLQAIDSRFTADIAEAFKYESSVEAKSAPGGTSRSAVLEQIQNLRAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYC2</accession>
    <name>A0A2T4BYC2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1359939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYC2"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="513" mass="59486" checksum="96A56026455FC12E" modified="2018-07-18" version="1" fragment="single">MSLPNLPAEVMHMILEALAQDGRDLASCAAVSREWQAVIEPQTFRRIKVTPPRIAQLNDMTRRNRSHVRYLWLCVELKRYDCHSCSFASDIEEIPMFIDAADDLPIKTAIQALFSVLSTWDSSSSLTLDMSVYSTSDREHWFKYLTFEPDDDEDDGSSSHGYSHAPRFNQAVSRENGDAQHHWDTTVNGVFKAQDAVLTVFTRILDSWPDESDDEETETDDLEWWRELPLVPAITRLLLRQQTRRRWVPEALRELLARFPRLCELHFEPWREWHDMLQMYKNAPQACYRTLLESPSIRRLRKLSIFENFNQRYMDAFWDADCSRIRPPNPTLGQILSEVCGNLEFLSASFMLDAEHSFDLDDVQPPKRWPNLRCLFLTSQLLAPDRDETRIADMLRAAARAAAHMPKLEALKIWNGRKDLAALFKYEAATEQGQASTITWKGTWVLHLQAPVIRAWQFLASEPSQQLRVVYESIASDQVRCHGDAMVLLELPQMVIRHVSLRQILNEQLYIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYC6</accession>
    <name>A0A2T4BYC6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1044934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYC6"/>
    <dbReference type="STRING" id="983965.A0A2T4BYC6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="77" mass="7822" checksum="2A99A0B5436903F0" modified="2018-07-18" version="1">MASPGHRPAIMASIEGSYQTPAATPTGSPDPDGMEPLLPPTSMASAIGGDSGSEATRPAKRGRRSNPKVKTGCLNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYU7</accession>
    <name>A0A2T4BYU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal binuclear Zn cluster-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1337622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYU7"/>
    <dbReference type="STRING" id="983965.A0A2T4BYU7"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="724"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="908" mass="101066" checksum="3C1D3066C1F1F5C0" modified="2018-07-18" version="1">MDRMGMFQVPPLGPPPLTHQPPQIFGSFLPDGMSSVQQLPPDLAAHMFPDSSLLLDDSNDAKRRRIARACDQCRRKKIKCDGKLPACTHCTNYKTECIFTQIEKKRATPKGAKYIEALENRLARMEKLLRLAGILVNDDDDLAELEKRLTEKAQQTAGAQSSAPSSPSRLTFESDGTASPRSSVTSPGFQKDKDRRQDDRHKPVATPVSLQGEEEVEALSEMMCSLVTNNCGETRYIGSSSGFSIFSPKGIQWINNKTGDVAFQNMISEVSEDDHKWTNWKPEIFRDLFQRPVFKPLPSKAEAMSLLTDYFENFNCMFPLFHQPTFMHLVERQYSDDPYQGSGWWASLNCALAIAHRLRVMSNLVPQEDDDKAWGYLKNAMGVFAELTMRNTDLLSVQALLGMALFMQGTPNPQPTFLLIAAAIRLSHSIGLHKKGTGFNLNPVEIEQRKRVFWIAYMLDKDLCLRSGRPPAQDDDDMNVELPDADPEDNIGNIPLADGKGKMNLFRVMCEFAVIESNVYKRLYAAKAAKQSDGELLATIGELDQQLEEWKDRIPIDFRPEHEIRASHTPLILHIVMVHFTYYNCLTTIHRMSVHHGFWTSRLANYAISGQNVRPLNPRVYSSAMLSTAAARASISLLKYVPQGDFSCVWLILYFPVSALVTLFGNILQNPLDQRAKSDVRLMNLVVTFLSMLGQEAEQGGVHRMLGICSEFCRIAQRVIEKAEKEQSSRRKRKAADTPGSTDTRNASSSPNTAATAKTMTPASSTQTPHQTGTGATTTPQTSVHDTLTPEFAAARASIHNAANKVTPSGSSPSVDSMGWTKDYQMPQDIDFEPFSDLTELGADVQSPPVPGGRGFPQPLLPQDLFSLSMSLDWNWVEMSGGAYPTVENGNFGGLETTGVLDPRNRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYZ5</accession>
    <name>A0A2T4BYZ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1403842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYZ5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="71" mass="7791" checksum="00EFCAA850E6DF80" modified="2018-07-18" version="1">MLLWLQMVSGACVSPVSNLPASAWPNGLKALTSYMHRDPVRLPAYVFAADSLLPPLTPLLRFPPHPPLNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZK7</accession>
    <name>A0A2T4BZK7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZK7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="82" mass="9402" checksum="AC00AED0E0EE7777" modified="2018-07-18" version="1">MTLSKPPQDLRQPPMQQQKQVEHRETPQLAQPPPPGHRYPLGSRTSPVPTWRFPRCGTLDAPHRHKPRFSASNCRSGSYFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZY6</accession>
    <name>A0A2T4BZY6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1471434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZY6"/>
    <dbReference type="STRING" id="983965.A0A2T4BZY6"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="MeTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polyketide synthase-like methyltransferase" evidence="6">
        <location>
            <begin position="164"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="431" mass="48450" checksum="AC36F96463250BF5" modified="2018-07-18" version="1">MAETWIQSTARNLVFQILKRIEHGRLTILTKYENGKNESVSFGGDGSDTEAEIVVIVKNPQVFVRLCQAFDLGLAESYMVQDVECDNLIGLFSLYVKNQHVLGASGGNFLYTLIPRAAHYLVPSNDTTNALKNASFHYDTSNNHFAGFLSPDMNYSSAIWSGEPGESLESAQRRKIQNILDKAEIAPTHHVLDIGCGWGNLAISAVQQTGCRVTGVTLSKEQKTLAEEKIKAAGLQDKITILLCDYRKAPVPEGGYDRVISIEMLEHVGDKYMNKYFQHISNYLKPKGGRMVVQGITRINSYISTGETVDNFIDRYIFPGGYLPSINQLLTSIHNGSHGDLEVETVQSIGPHYIRTLQCWRENFEANWDTIRQDFATKNPSATDSTIEAYRRQWVYYFQYCEAGFRTRILGDYVISAIRTPWPEIPANVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C053</accession>
    <name>A0A2T4C053_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1464167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C053"/>
    <dbReference type="STRING" id="983965.A0A2T4C053"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56425" checksum="E4525862FB4F30DF" modified="2018-07-18" version="1">MSKAGENVILPSNAVFLVHKVGTSKAGHETQWETRTKPMRTAPGPNPVLSIANNKNEPVKAKSDAAEGGSWEFVSYTPRKDRQQLPRRPKEKEPKRKRRVQNRPNSHENTNTSLVSLRQDPKLLRNPGDLPPDLPVALFGHALLYVNFYFHSIATGAYSLPCLLFNPAKRDWFPRMMQDEAWRCIILSLSASTLASLTGSSSNYVDSHALLDEALRQLKSRVASGALPSDQTLGAISCLSMWSNEQGNLDKGWVHAKGLAELVKLRGGFSKISDGMRSKLYRGVFDIAVNSDRPPLLDDGLRGYPDNEVVSEDDDLETDKSDLSSFECRISPRLSSMFDDVVQFSTTVDDAITRNIKLDTNSLYDLVFGLYNRLLSCQSDSMSGCDNSLRICLILYIKSTVSHDNLNTTSMHLVKKLQASLQDCLNIHSSTPLTRWKLFIGGMAATDGTPEKQFFLQHLAEALAETEIAGEDGWGSLQAELSSIVWTRPINEAAGQKLWLQIAETRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Q4</accession>
    <name>A0A2T4C0Q4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1439740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Q4"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Q4"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015529860" evidence="7">
        <location>
            <begin position="24"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="545" mass="61715" checksum="4963549A15E09239" modified="2018-07-18" version="1">MFKAWVTLGLIAVTVLLWQLSRIGRRPSNYPPGPPTLPLIGNLHQMPTKNAHLQFQKWAKEYGPVYSLMLGTKVAIVLSSDVVVKDLLDKRSSIYSGRPELYMGQEIMSGSYRPLFMGNNSVWKMVRKLAHGVLSVKVSRTYVPYQDLEVKAMLMGLLESPGNFLNHIRRYTTSLTTQMAFGYRTPESDDKNLLEMFGNFEELSKLTGSQSAAILDLYPIARLLPDFLLPIRQMGREYHEREIKLFMKHFQNARTQQPCCAIDLLCAQKEYGFSDELGCYLSGSLLQAGSETTSIILVGFFQAMLAFPEVAKEAQAEIDRVCGDRIPDLNDFPDLPYIRACMKESLRWMPATALGVPHAVTQDDAYMGYHIPKDAGIILNVWAIHNDPERHPDPRRYNPARWAGDNQNSAQAAVNPDPSKRDHFVFGAGRRLCQGMHIADRSLFLAIARTLWAFDLKRPVDKQTGKEIIPDVDNIKDGLFISPMPFAADIAPRSERRAAAVREEWGKVADLFDEDMQWKTVPEGLKWKDYEPLDDDNRDVLESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0W2</accession>
    <name>A0A2T4C0W2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0W2"/>
    <dbReference type="OrthoDB" id="3700495at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="81" mass="9573" checksum="077B983C0442514A" modified="2018-07-18" version="1">MCNYIYKELKCQHHYHLVESWCPKYIATERRCTPTIVSKQYWGDDICAACRERQQPSNHPWAKLIRRPADRTAPQASVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1F5</accession>
    <name>A0A2T4C1F5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1471114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1F5"/>
    <dbReference type="STRING" id="983965.A0A2T4C1F5"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="55"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="826" mass="93566" checksum="93519347F194D905" modified="2018-07-18" version="1">MHPYSLYNYYRPTMTTLNFEIRILRLEPSTPSSSEIRASLIKSSLLHLREQGVFFEALSYTWGQASVTKDIIINGTTFPVTANLYAFLQQYQEPDQTADLWIDAICINQADLLEKNHQIPMMTMIYAAASKLVIWLGESSSDSDLALEWISHLGSGSPYDKMPNTPNNAWQAMQSFLSRPWWKRIWIVQELVTGAMGIKLEKASVLCGNARIAWMNVVIAAARMKAYEDDKRQAFPTITEILELDSLRDSAGNYFMKQPTPQGLFDLICRYRHFLATNGRDKIYAIWNMFATVPSKRLEARYDRSVEEVYVDFAAQLLSGETGLELLRHCGNGSPDIPSWAPDWSPEYDAPKGLIGADGTRTESNVGYVISPLVNSSEAEKERERRIKRLEWTAKGSAAVKSLDDVPAHFTIHNVPEATKEQIKELLPRDDVIFVIADETRHLPDNPDVVQQVELITERKMKKWLLQELRHSDAEPLYKAAASTQATLNIDKSTRSLQAKGILWDEIEVCHDSFVRDVDEDFVDATRFMVAVGCCKHLAMTNQSAGRMYPQAADLLEAFWSTPFPRYQEWLPEIPESWIPGEPPVTATTTGLIEVAEVSEALNHSMFATHAEKGEGSPQFLNQLRPDLKERVFPAHDDEHVALVSRLASTWSQQPYDLYHRPFDLLSVIPDPYWGTRCQENEIAKQQARKRKAGCLKSSLDAIKDPLDREFLNRAYDRVDEVLKQQPSLVPQDTLPAGIEKYALGRRFFITKKGYFGLGPQKAEPGDRIAVMLGTGVPFVLRRCSTAEGKRGWKIMGECYVHGIMQGEVIQKWELGSAEARMLHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1I7</accession>
    <name>A0A2T4C1I7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1439940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1I7"/>
    <dbReference type="STRING" id="983965.A0A2T4C1I7"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="284" mass="30944" checksum="C6C8A280617BEDD7" modified="2018-07-18" version="1">MAQTNLPSYYARGHSDYTIATHLRRKAETDAAFLLPYIKPTDHILDVGCGPGTITTSLAKYANQGTTIGIDISLDVLQKAKALAEESGVPSQGPGSVIFEEGNVVDGLAYPDNTFDIVFSSQVIGHLPRPDIPLRALAEMRRVLKPGGILATRDGMGHHFYPQSLDLDRLWGGNQLRASRRGAPEADPTATMMPALLRSAGFNADGGKVRVGAGASVFSEPEARQRLAWRAEGQLQKGDPFYQTWVDAGISEEEIQQTLDAIRKWAGMQDAWLVILQSEMLAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1J4</accession>
    <name>A0A2T4C1J4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1274535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1J4"/>
    <dbReference type="STRING" id="983965.A0A2T4C1J4"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="276" mass="29037" checksum="71CADD7749A47525" modified="2018-07-18" version="1">MSQAELINSPFQLNRIYQTLPIMSTDFSGKLAIVTGASKLNGIGFATAYALAKAGADIVIHYNSNKAAAEECLAKIKELGVKAIAVQSNAASVTFGTDIVNATVAAFPNRKIDILVNNAGHVTLQDSPAKTTIEEFDALFHPNVRGPHLLTIAALPHLASPGGRIVNIGSVVARTGTKFATLYSATKGALNTLTLAWAEELGDRGITVNVVAPGPISTDYAPPEEFELTQKFRVQQRVKRNGTPEEVASAVLFVASQGASFMTGQVLGVDGGLSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1K7</accession>
    <name>A0A2T4C1K7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_20556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1K7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="281" mass="29819" checksum="0E61CFEE2CDB2D3F" modified="2018-07-18" version="1">MHAARSQVLCAATGGRPHGAYPVHSLVALGNRCSGNLQPTGGQATTSRTWGISGTRLIGPTKSRRQAKASTVHTGSIQASKPPNVVTASTPATHRHFKRLPVLILLATPRGCRKTRSQSTPSIAKDGKTLELPTSSPPLLSVQSFGHHLMNTNTIRAAHPLISPARAVICFLLDVPLSSYTPRLATLNESTYPDTDIDYSFAKLRPIVNYVLAPPDDSTTAEAPSSVTGTLGNHGAVSYDFARGFLPCDLTVLNPLISERRHTGGTATKVDNHTTTALLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1W6</accession>
    <name>A0A2T4C1W6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1255792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1W6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="108" mass="11683" checksum="D6E548A32E86CB09" modified="2018-07-18" version="1">MGEAGAPKAKSVGFRFVLVRPTQTYIHTCVLGTFLSVLTATPADFEAVSTLTSVITLEWLRRPSPFGTRTDTALCPVDLVVNWVNWPSSAITARARLHLCGSMLGIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C208</accession>
    <name>A0A2T4C208_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1334520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C208"/>
    <dbReference type="STRING" id="983965.A0A2T4C208"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="264" mass="30003" checksum="D7714524D52FD947" modified="2018-07-18" version="1" fragment="single">PNHPVQVQGYVGLFTWLVVQYDDIVGLGNVAGNEMLEDALKFHARFFRGEPQGNNLLEGIAILLREADDHFDTVMANMLQISVLKFLTSNLLERHDGFQNMKVTRAGIKFPDFYRDMSGMNVAYAVFCYPKAQYPDAAAYLEAIPDMARFIDISNDVLSFYKEEVGGDTRNFLHNRANTTGKPILEVLKEVSKETMDCAKRVEQILKGRGVYEQSWQDSVRGYMAMHTTNPRYKMSDMGLGEEHPLAPFEHKIGEFFDRVNNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C233</accession>
    <name>A0A2T4C233_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1257240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C233"/>
    <dbReference type="OrthoDB" id="4898821at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="416" mass="45252" checksum="30902CCE4BE7D3AE" modified="2018-07-18" version="1">MPITASQDNAATGSTMTVTAAPKPANGILKASSGRGSRATPTSPPDTECRLKRSRSSSPPDDQEHEIHSAKVSLLNSPSLPTVPAFPSAPGAAPTTPAPLTPPGSPAKRSIAARASPRITKQPASCLLKKLTMSEIAPFVRRQRQLLHEMVKAGVIVIHPNVIVRVGIDGLLEVDGTKDDQGAVKVGSKVFSKDNIPDGEPPAFVGGAGIHPSLVNKDGRRLTHRDFLKRQGDSIFYMWIVKTLSGLPDMTHERWWDAVDLLQKLRPGRRTQKALVEPLYKAHIFDTMDRATIHNVGVKLNAYDDLTDEEIDIKLPIAIGRLMGLSPPTVLSTRDVWQDQFCAFAFEIDGGVAEAATSLLSILKLMAKHPNADEHLRPVAMEKQEELETAFEKIQRLPELKSLHNFVESAVKAGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C257</accession>
    <name>A0A2T4C257_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife protein DSP-PTPase phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1378178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C257"/>
    <dbReference type="STRING" id="983965.A0A2T4C257"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife protein DSP-PTPase phosphatase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="344" mass="38442" checksum="FED1D60EB39C072C" modified="2018-07-18" version="1">MTVIPFRQSIPKSVLSPDPAPSVKVLKQQVSMPLPGLGDDCLEIDQEFFISLYGTDEVFTAEGKSLRVRPYINKRTQLWKCVRDSSNRFAFMNQATRMFLGRDKHENLGCSAPRHGEWESLTFTKLTTGGYELTVPFESRLSHVERAADSGGPYMTVTIIFVQPIGLHKFNAGPFLNFRWVVPGRLARSSAPHYRSSDLDQNMDAEALEYLKDQGITGIISLNTCCLPATAVTRIQEYGMTYDHIPVAESCAPTMDQFRELWDVFRCQTVTLVYSGFGFGRTGTAVCALQLYSHRALSDVGFRMNCVVTPDQLGALNILRSVLQQTLPASEVFRPDEGCQSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C284</accession>
    <name>A0A2T4C284_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1402166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C284"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="335" mass="38522" checksum="81796C69345FA5BF" modified="2018-07-18" version="1">MPLNIHIVDYKYVERDLERAIPDNYNTNFHTAADAPDDPIPSNKPFSYDIWLPPILRSRGVPASDLQVIVLHRPQIELLVKAAAASIHTRVLNRSYAEDLQEEVYPAFQSLTFPPEGLFMRLGACSPKDGAHTTPGVLSLQSVEDIVLRMTTSLRTWSALTNVLNSDAEETHAYFLTFDPRLQSSREYRVFCCPESLRITAVSQYEWHKPWIFANKDRDRMGERAQSIVDGIEKVHDEILEFMQAQEDPELERVIRRQGFTFDVFYDQLDDVCRLIELNTFGVRSACGSCLFHWLRDRELLYGNEGGPGIVFRVTMRRDETDEKGEPWSVRICHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2X2</accession>
    <name>A0A2T4C2X2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1334705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2X2"/>
    <dbReference type="STRING" id="983965.A0A2T4C2X2"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015648782" description="Peptidyl-tRNA hydrolase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26517" checksum="28FF832AC6B867C7" modified="2018-07-18" version="1">MRFSAAALVAALPALSAAQENPLDQYVAQFQQLVGKYSAYLPSPSKYDDVAAHEAKTGPKKLSVLGLHNWEETLYEPVAPDAKVPVEWWVLISGGNKTCYGRCGQAEAAFNETAVKFAQLPTAPHMGYVNCDDQPILCNSWSAGVGQIWAFEMLPKPAPVDIYKKRLNLTTVTSDELVGLYEAGDKKDFTLINSWFHPFNGKAKELGLAIPFGYFLWVFNLLPQWAFMLIVSFLSRSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3A0</accession>
    <name>A0A2T4C3A0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1334418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB76004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3A0"/>
    <dbReference type="STRING" id="983965.A0A2T4C3A0"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="109"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="242" mass="26331" checksum="6F5F287434F5FEE4" modified="2018-07-18" version="1">MLSRGCTNGASAAKSFIQLAKRRYSVAPFHAQQTPLEFLIPRRVPQAPRLRNVSSAARFGQRLIITQVSKASVLPVGRNTSSRSFTASAARLATICVRNPVKDEEGKEMKLEITPRAAQRLSEIMAKDKNPNLALRIRVESGGCHGFQYLMSLITMPTGEGLEASTIINEDDSIFQYVPDDTDSAAPPPNSPKIILDEPSLELLTGSKVDFTQELIGSQFKIVDNPYASSSCGCGTSFDIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3N8</accession>
    <name>A0A2T4C3N8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad17-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1401602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3N8"/>
    <dbReference type="STRING" id="983965.A0A2T4C3N8"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="234"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="820"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="876" mass="95499" checksum="C0E01841BFFD6C6E" modified="2018-07-18" version="1">MAPPAKRRRRNTVVASEDEDEQPKANTLTNFLLSSPNSPAKTRAPTASPSPAKRKTANGQQPSSNGSPLRPSRSLKNGTTSSPRKTRAASKADDKGKTADLKMLFSKQAQKATRPAADRRTEPIDDLISDPISDDDDDEISERQASSSSLVGQHVRKRLKGTSGAELPVLSGSLTMSQRFLKPSRQAAIDASNDDLRPWSERFGPRNLDELAVHKKKVTDVRRWLEDVMGGRMRQRLLILKGGAGTGKTTTVRLLAKDMGCEILEWKNPAGNAVNGFVSASSQFEDFLGRGGKFGALDLEDAEPFSTPASSSKPSQSQQPGSNGKKIILIEEFPNTFSRSSTALSSFRRTILQYLATQTPSLPMFGHQRPVEPITPVVLVISETLLTTTSASADSLTAHRLLGPEILRHEGVGLIEFNPIAPSLLAKALEVIVQKESRKSGRRRTPGPLVLKRLGEIGDIRSAISSLEFLCLKGDQDADWGSKVTFAKQKKGAKDGIALTRGEEESLEQISQREASLGIFHAVGKVVYNKRDEVPSNDPAEKLPSYLSQYSRPKPSQVSVDTLVDETGTDTHTFISALHENYVLSCEGTDPMDLSTPIDYVNECIEYLSLADLLSPSRDVFFGGRGGYGGTFGGDSASHVLRQDEITFQVAVRGMLFSLPNPVKRKAWTMQKGGDAFKMFYPTSLKLWRTKEEIEGLIDVWSGKVLRGEAELPTRSIMDGASIFRRNQPSGVSSSNQDQKPTTTKERECKEDARQNAEAARDSPPVPTLGSTARRELLLDRLPYMAQIARGRKVPGTRQKDLEKIVSFSGVNMALDEEEADVDDDGATGETWATDKPSEETSPRKKRVGIKIGGAGGGVAGMLKQKLVLSDDDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3R9</accession>
    <name>A0A2T4C3R9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3R9"/>
    <dbReference type="OrthoDB" id="4876528at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015641264" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14627" checksum="76C811936EDC15D4" modified="2018-07-18" version="1">MQSCLLAATLLSLITLGLAAECHPKVEPIPSFSIADGRNLQNDIHGNQFDPPLDFPFTIEPAHTASFSVGSAIACLENGYSFESTKIGQTDLANAIQNIMDECDNGDGTSKGGRAEIIGDSGLPLEILIQDRSLGCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3U1</accession>
    <name>A0A2T4C3U1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_355315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3U1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="24360" checksum="C9B0B74537B4E04B" modified="2018-07-18" version="1">MVHDLYKMASRHRRERLSCTTIPPHILTEQAEQIPSPRNNSTLADMSSYFDQVEALVALRDCNNCELQSEIYEALTDALFFRLIAPEDSGPFIIVTEVAWCHGYYLVWKLRIPKSQEPDWPIEIDSDLREDAAEVFELAARELAEYQTGYRDDGYTTSIDGDRVTIFNDTFERVACLLSTAYLTISPEPVESLLYLLNPAGYLNIYDLGDAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C419</accession>
    <name>A0A2T4C419_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1377298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C419"/>
    <dbReference type="STRING" id="983965.A0A2T4C419"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46410" checksum="1B435048343557C8" modified="2018-07-18" version="1">MANQDITLGWELELILHLQPGEQPGLALEAHKLRDLALTIAQQVPNLPIAASCIHRPSASCPVCEGAPAEHRLPHVRVVNPATPIRKAHGPIEDSYYFVKREWLNVPTDNDGDRLAHGYEITSPILSTAELRAGLPQTAQILAAIRKSGLPISAHTECGLHVHVGVKSGMTLAIAKKAATLVMLLELPLLKKFASEERSESRYWFIPISKRSKFMSYADRYHDEVTDAIASPELRQHLPGLSDMKPAEWNSNEPKRMHLALNEMWLTDSIWRLSTGFFSYEGQKASLVLCTRERNGESASEPARGAPDNLEGTPSTLEFRYPPMSFDIDFVKCWAEIGCRIVEVATSDVAAFRQVATDLLKELESNDAAQWERLLKVLGLDHQVPFWRQQLARFDDDEPIRFLDDDGFLIPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4B3</accession>
    <name>A0A2T4C4B3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_4882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4B3"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49289" checksum="9850501D4E686C8E" modified="2018-07-18" version="1">MYPESPPRLNPLLPVFVPNPPVEIEIIPLSSSPTLGPEHVEYITAEDIIFTIETSPEPRPPSSLDDSVEILFAEATEHAALQRNPFHGLENGAELEAAIRSFLHRPSTTTNTLLQLMDFLAEDPAYWPPSDLIPRAFLSDKITFIQNILGDLSEEFGEQEFNTLQFVYFCMMETHRVHLISTEDWEQNEYFMDMTAELPRSLFRYVDVADPSRLAQNPVEQDIALARDGNVCILTGAADPKACRILPFATTANQYNAQSSWAFWYTMNDFLDEESRAGFNSLLLTAGASDKAWNMLSMTLAMGALWKKGHFAFRCVRITPVDGDRAVIRLQFHWMPRNDVDPKAVATLTEENILRLLQDTSGLDGPGGADARRTTGRRVENGHTFGLRMTMAEAVRMKVAVDIQWAAIRLAAISGLARSWDAGNGDVDLESFYADNIPFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4D0</accession>
    <name>A0A2T4C4D0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1401873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4D0"/>
    <dbReference type="STRING" id="983965.A0A2T4C4D0"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015451960" evidence="1">
        <location>
            <begin position="19"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="362"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="851" mass="95528" checksum="A8F10649F7302DA1" modified="2018-07-18" version="1">MQCLSTCIILSLVPFTTALSHYKPSSSDYHANAGVLQHVNPLIGTRGYDPNDLGGMIPSVSPPFGMTRWTPQTRENFISQVPYNDRDRRMHGFQATHQPAIWIGENGHVALMPGLGDDIRPLFQHRGLAFRKEDEMSTPYVYEVTLDADSGGEFGWNLTEQATSELLGDACPPCPGGAAFVPNKDVTEGANGRVRRDYVFEPENQDAIALQSVSANASDHGHTERKGYENSLQVALSASAHVGHLRVNFQDTKKRQPYFIIQASRLNWTGHVEIDPEAQEVSGSNSQRQEYLLGPDKPESFRLYFVSRFSAPFTSYGVSRAGDLYKGQKYIEDKFVGGYVIFDKAVPRVEVRTGVSYVSVEQARRNLDIDIPDGTAFETTVENVKSAWLERLGRIKISGVNETDADHDPRTIFYTGLFHALQYPSDYSEPTTSSEGGTRRFYSGYTDSVHEADDSYYQSWSIWDTYRAEHSLLTIFAPERVNSMMRSLLRIFDWSGRLPLWNNMIENNEMIATHVDAVIANALVRGFNDFNVSRAWDAVYVDAYVPPDNDTDLLYYSREPNTPYECRAGLTSYLEHGWVDNDRWAESASRTLDYSFDDYAAAVVAEHAGDLEHAKELRERSQNYRKLWNPETEFMQARNANGTWANESWGWTEGDKWIYTLNVMHDVGGLVSLFKGGKKAMKARMDEYFAGGHNLHSNEPSHHAPYLYSAIGYPADAARQIRELAWENYNATASGLSGNEDLGQMSAWYVLSALGFYPVNPASDEYVVGTPFFDEVEIRLPPRPGDFGEEHTLVISAPGAGTEGKAYVKSLKVDGEEVHKPMLKHGQVVKAKRIEFEMSDEPTSWGQEGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4W3</accession>
    <name>A0A2T4C4W3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1332616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 4">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4W3"/>
    <dbReference type="STRING" id="983965.A0A2T4C4W3"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="191" mass="21024" checksum="0A2723D072284E61" modified="2018-07-18" version="1">MADSEQPEAPVEPQGRHVVYCGVCTLPPEYCEYGGTVKKCQEWLEKNQPAMYERIWSAEALEAAASSLSIDAQKRAAKDAQKKAAKAEAAEQKQATKLATSVVTIKRIERNKKKFVTAVIGLEAFGLDLKKVAKDFGKKFATGSSVTKVPSGGEEIVVQGDVSDELEEFILEKYKDVPEDNIELVDDKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C510</accession>
    <name>A0A2T4C510_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1312722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C510"/>
    <dbReference type="STRING" id="983965.A0A2T4C510"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015709944" evidence="1">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="275" mass="29124" checksum="9BBAA5E89D304023" modified="2018-07-18" version="1" fragment="single">MLSKSIATAALALAASTLVSAQTSTDCNPLEKTCPNDPAFGKNSGECDFSKGACSSFESLPGTSLKYNGNGAVFSISTEKEAPTIRTGKYIFFGRIDVVVQAAAGAGIVTSAVLQSDDLDEIDWEWVGGDNSQAQTNYFSKGNTATYDRGAFHPVDNPLGSFHTYSVEWTSAGVTWLIDNNVVRTLTAANAQGGADGLPQSPMQVKLGTWVAGRKDAPQGTVEWAGGYTDFSKAPFLGYYKSISIVDYAGADAPTSKSVKEYIYSDHSGSWQSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C518</accession>
    <name>A0A2T4C518_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1231377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C518"/>
    <dbReference type="STRING" id="983965.A0A2T4C518"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="140" mass="15722" checksum="3DD80E5B4ADC0BBF" modified="2018-07-18" version="1">MSAKVPRNFRLLEELEKGEKGLGAEACSYGLEDGEDLLMSNWNGTILGPPHSAHENRIYSLKMHCGEKYPDEPPTIQFVSQINLPCVNPQNGLVDPKQLPCLAQWKRENTMETILIELRRYMAAPANKKIPQPPEGSTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Q0</accession>
    <name>A0A2T4C5Q0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1236560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Q0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18423" checksum="7456A3E273B7A5B0" modified="2018-07-18" version="1">MGEASRLGKKGRSLTARHSVFSLGIVGLALKLRIVLTWMVCCSLSFFGYYSFPYPLAKSFAPLQMLFTLLVTRFCSPRRERECRMHVRWNWNGSSRRPKKTHGYFSSSDTGDMALGSLLFFLLLIPMGRMNWGSVTGLPSGVDRQRGTSPRWSGSEQPGRMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6C2</accession>
    <name>A0A2T4C6C2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1355592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6C2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6C2"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015574387" evidence="5">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="7">
        <location>
            <begin position="375"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="465" mass="51992" checksum="1916F7B74987B556" modified="2018-07-18" version="1">MKSSISVALALLGQSAAWSYDTKTQYRANIKVNARRTYQTMIGGGCSGAFGVACQQFGSSGLSPENQQKVTQILFDENIGGLSILRNDIGSSPGTTILPTCPATPQGKFDYVWDGSDNCQFNLTKTALKYNPNLYIYADAWSAPGCMKTVGTENLGGQICGVRGTNCEHDWRQAYADYLVQYVRFYKQEGVDISLLGAWNEPDFNPFTYESMLSDGYQAKDFLEVLYPSIKKAFPKVDVSCCDATGARQERNILYELQQAGGEKYFDIATWHNYQSNPERPFNAGGKPNIQTEWADGTGPWNSTWDYSGQLAEGLQWALYMHNAFVNSDSSGYTHWWCAQNSNGDNALIRLDRDSYEVSARLWAFAQYFRFARPGSVRIDATSDVENVYVTAYVNKNGTVAIPVINAAHFPYDLSIDLEGIKKRKLSEYLTDNSHNVTLQSRYKISGNSLKVTVEPRAMKTFWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6K8</accession>
    <name>A0A2T4C6K8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6K8"/>
    <dbReference type="OrthoDB" id="4083871at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="10594" checksum="A81F787B232BBBA2" modified="2018-07-18" version="1">MASTLGQLIPLLIAIALLGGTSWVLYQIYLSLGAVRASASERMTRSNVVFTKDGVRVGVRGMQNEKYVDKTQSYVVKAWNLGTAQRDDEMKRKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C759</accession>
    <name>A0A2T4C759_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1374591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C759"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000283">
        <property type="entry name" value="Anaphase-promoting complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000531">
        <property type="entry name" value="Negative regulator of mitosis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1885"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1886"/>
            <end position="1896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1951" mass="216576" checksum="231076854F6DA161" modified="2018-07-18" version="1">MATVQSLGLHKPAGLQHAIDEQLLPPDASASSYAWDVVTDDDREGSVEDELLTTANCVVWCRGGIFRKSFRFDLEKESITQALLTYFPTSEDEGGGRKASTALEKGLVVFLKTQAHIYMLSGTSHVVHMPFEVESACAAPVGVIIQTKQKAENLAPIALKFPRVPPNSFVSSQLTALGGSQQTAFSVEGLGKPKALPVGLNMTLENMWDAPLEQPESHWPRLVALTDPLLDIGLVVTDAEKQASKRGKRDKPRKVHGFLDPAEELLYVEKVVVPSTSPERPHEPLILGVTINREANTYTIWRLSYLEHQDHFIKRRKCPSTKASRRRSSMQPGFASGASTPVQASHRDSFGAPLPGKRPRKSEKIEKPLDLVSTLEKQDMESTGAGRRSSHRLSSVLARADLSASYDRAVFPEQSSAGGVSSKRHDSLGHHGRSSASFVYQAHHSLGSLLEAPLDAGLDERIHNIRLDDHEFDGLQHEILFSRIHVIPIDSPNVRYSASGGTSRGHTKIFVLAAPPFATNDHQTGQLLIGIQEVMEKRLQLVTFSLKLQQKSDAAVTSGKREPSPMYTVSVPPGELVRAHDVVDSCKIIDGDQSAILVLSESRDGRHELSIQAPWSEMTKLSISLLFVDDTKSLQFRGRAVDRDVRQRKSEIIDLTNGSIVGVCHSRHRGVVDVVDTQGRLHQLKIQLRPSSGSVSAILNICRSVLPDSRGERIHTGWLHVMQWLYSQGRADTNVEWSALTILLLALFLNLDRPELRNPPSERLTVRKRRIPSGSFGSIRDSDDWKALEMGETVNSLGCPPWMINRGWQWVLDDDVEETSSQSGTPGLGTKFISRHIALAKEFMASSLGTNALGPSGYLPTSLGRNPDYKRKAAVDIFMALHLLLEEQKLDIMSAEYLPSGRADFRVILCQIARWLKWHNFSSFYDLGIQEDLDPRHDQELRLKPAIPEPPDRPDILEWIQSRFSGVRSQQYPIPADMFYATAQLSESDKLFDRRWDSILPRTLTFRRFFRLLQPNTTAVQMVEAMKDCGLTNHVLDTLPEAILVPLRDAIALCQPHPPSSWTEEMLEFVKRTDISLVLASNKRPRPAMSNILTPTHTASWEFKLLCESVEQTNSQGYDEGEGTERQSVIRALFRDDRRLQEARDLLATHKPRIVTLPQDPGLPESEYLEKQKELVSRIANGTLAIPAGRGLLYYSLRFPLITQKFHIGGFNLNCVVKPNNVTVGVDKTLFTEEKVCWGFFHQGVAAGLAISPLAKGIDTSWILYNKPGQDLSNRHAGFLLALGLNGHLKGVAKWVAFKYLTPKHTMTSVGLLLGLAASYMGTMDSLITRLLSVHVTRMLPRGAAELNLSPLTQTSGIMGIGLLYCGSQHRRMSEIMLSEIEHVDDEDEEEPLRSECYRLAAGLALGFINLGKGNDLKGLQDMRLTEKLITHATATKNVEIVHVLDRASAGAVMAIALIFMKSEDQIVARKIDIPESVLQFDYVRPDILLLRTMTKNLILWSQIEPTFNWVQKSLPAPYRSRHKLQSTTKLRSSDLPFFSILTGLCFAIALRFSGSASPKVRDLLLHYLDQFMRITGLPATPRMHPDAAPLYDEELARTNARMCQDILAVSCSIVMAGTGDIPVLRRLRALHGRDDPDTPYGSHLAAHLAIGALFLGCGTATFGSSNKAIAALLVAFYPIFPVNVMDNRSHLQAFRHFWVLAAEQRCLVAKDALTGQPVSVPVHIKMRGGSSIESVLYRTTPCLLPPLDQISSVTTAGGPQFWDVELDFSNEELRKSFAQTQSLYLRRRPPREGAFTSTLRALGEQGKGENPLEWVLNLDALRDLTYAEKAALLDTGDEEQGGIGSAVDARLEMERGIEEGGDRERLEGARLLFAWGDARENLRQSSSVSMADSQSTVKPAKSQDESTAAEDVAAQHEETEDEGDGVWWMRDSAIEALKGKAWMVARQHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7C1</accession>
    <name>A0A2T4C7C1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1329903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7C1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7C1"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22676">
        <property type="entry name" value="FHA_SNIP1_DDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="317" mass="37047" checksum="65144FE16A4A0BE1" modified="2018-07-18" version="1">MAPREDPDQGASRQHQDRNGDASRRDRDDSRERRRRRDRRSRSPDRPSARPRSRERDRETRRYRDRSRDRSRDRSRDRDRDRDRDRRRRRSPEEPDSRRRRRRDPSDDEAPGRDSRALARHRNSPPMKRSGPLPSQQESFAGTTTTQEGEDPEKPKEKPNIGTTGRLAALSNSVAQADGSSIVLKYHEPAEARKPPPRDQWKLFVFKGKDIVDTVELSARSCWLVGRELAVVDLAAEHPSISKQHAVIQFRYTEKRNEFGDKIGRVKPYLIDLESANGTILNDEKVPDSRYLELRDKDIIKFGHSTREYVVMLAPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7L4</accession>
    <name>A0A2T4C7L4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_52218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7L4"/>
    <dbReference type="STRING" id="983965.A0A2T4C7L4"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="657" mass="73315" checksum="D28164AE7CA71D13" modified="2018-07-18" version="1">MQEGQQRQSGARPYRSHLRPACVPCRRRKSRCQTAGDAAVCLTCRAHQTECFFPGDSRESTSPGSARRRRRVETRPSSSEPSGANPLRVAQAAASFRESAKDNTSASVAGPVPDVPPRPIAGMSRTGQNYHDHEEESTLALGSDDDQHLNLHIVGPAATNEVLSTYLSGIPGATRSTRLIIPEPASCSRPVLFTEVQKRPFGVKLNRSPSAEKLEIIEKLLEPHNEAVIDEYFKKVNVCLPLLDEVSFRRQYQEDKTRISPALMACLYAHTIVYWQSSPTLSRYRCPESRFIWNLANEAVYSELHLSPGMSIIKAIVLNIGGRPTTSLIGNGVLLGSAVSMAHSVGLNHNPLPWKIPQPEKYLRMKIWWALLVHDRWASLAHGTPPHIQRSQYDVPPPTLEYLGETLIETNNPRSELRANVFISLVTLSEVLGRFLQYVYCVGRDKPTTTDLEHALHQWTDTLEGPCRRIVLRGSHLDVTGAANLRLAYLTAKLLLQRIQLEAEKQGDSVSEEGVMNRYSEARMTSEEILMLIQDLQPEHLGDFWMSVSAFAFPAAVNFLLRCALETENSPEGLAQSPSFRIARDLITTLRSHQEQHRWDLGDVCLAQHAEIVDKMLTGAVPDEQGGNNGSLDLQDFDVSILDHIFPSVWDPLQNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8M8</accession>
    <name>A0A2T4C8M8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1330464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8M8"/>
    <dbReference type="STRING" id="983965.A0A2T4C8M8"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="79" mass="9262" checksum="8DE3E4C4630D3F10" modified="2018-07-18" version="1">MIIPIRCFSCGKVTGDLWERYLQLIADPRKTDGDAMDELGLKRYCCRRMIMTHVDLIEKLLKYTPDGRNEKKQRLNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8W3</accession>
    <name>A0A2T4C8W3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_251011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PTB78017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8W3"/>
    <dbReference type="OrthoDB" id="4898977at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="522"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
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            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
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            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
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        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="522" mass="59478" checksum="1DB1DB8BD1800EE7" modified="2018-07-18" version="1">MPIWTRGNYVPEIRPFDPPYFFRISQCQQWGKVTNEMLGDELLWRTYWKRFNTVEIPILPQDEFFDTALSIAKLAGGRRKEFERIFEEKNKERWEEVKRQLGKTEYHAKCHKEAFPCEDARKKLIKVCETGCLTHFLDILKGNAYGYEADVVRDEPPENAPKGYDEETQVPEDYFDEDGMPRSQRFNYDPDICFYEEPSTNDWREPLMADNVFYIGSYTVEYAPPEKDDDGRRTPSPVTGNTSTTSPLLPGSASTPKRGDGEKSAQTTRQGKRKRLTRKSVHFEDAVDVESHQHQQQLGPDDDTQDDDRAHKRARLDATSPDASSLSQPATDESVSKKRTRQDDDNNDRQKRQKLETPTSPAPAPHVSSPIPTATTKREPRRRTRNNKGDDHGRTHQGLEDSLACPPTPSASSTTATGSTTSRKRSREGDDEDNGFKRQKIEDPAAHTPPSVGLSYTQQTTGERPNDQKADARKTRKRRESSTRPSRQKPPPAPRSLNTRSRRKGGSSTFYQLDQSGKPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C908</accession>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="192" mass="21391" checksum="A643FAC56D15F050" modified="2018-07-18" version="1">MYQPYSARCCMRDVISPSGNLRTKYISGYSRCQTCIHPLRRAWPAAVTVGMTGKCCDQPLPHPRISQCSYDSIKKDYAEGPPFCLISERQDPTSYGTANGGHTTTHIYLSCYLPNNHLEKITSTQHLRHCVTSAASFKATLSAPACCATPELQLAMVIWAQISFPMLQIRRAVNRFNGDSISLISCIFEKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9F6</accession>
    <name>A0A2T4C9F6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1389886</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="983965.A0A2T4C9F6"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38161" checksum="226E94BF8AE2EB28" modified="2018-07-18" version="1">MPGGVCAVLDYEVDMMAEYVAEMATRVVTPEASVTSPFRKFVSQILTSTRLPSTTILLGMNYLAKRINSMKSQGPYKASEGQVWRFLTVSLLLGSKFLDDNTFQNRSWSEVSGIPVSELNTLEYDWLQAMNWRLYVNLDHSKDYQAWLDNWREWQQMKKRRAAQASRERLAALVPAIDTDLARYNSNRCSPQFRYIQAQVAEYERYQAMKAQQHTYRSRETTWANNPWNAPLTPPDSGYGTPEYAVSAASSNARYNEWFAQAAAQYSSRYPQPPAHNTFYPNRQSPYSSHYPYNHHHSGWEHGVAECSCSGCVEPMKQTPYFMAHGYGQPVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA41</accession>
    <name>A0A2T4CA41_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399538</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA41"/>
    <dbReference type="STRING" id="983965.A0A2T4CA41"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
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            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
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            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="42390" checksum="D1FD1898F1C7C823" modified="2018-07-18" version="1">MSSLINKVKDVLHSDNKSEQPEGTHGPHSSRAANAADPRVDSDRDHRDNLGRHDGSYTTGGDNYSYGAGNTATTGTHGTTGTHGTTGTTDFGSGPASKTAGMHSSNLANKADPRVDSDLDASRNMGMKSHGATHGATYDSSTTGTTGYGSGTHSSSGTTGYGTGSHPTSGATGYGTGSQSTQTAGMHSSNLANKADPRVDSDLDGSRNMGMKSHGATHGTTTTGSSTGTSGTTGYGTGSHSSSGNTFGSGSNATKTAGMHSSDMANKLDPRVDSDLDGSRNMGMKSHGATHGTGSTNTHDTSFGTGGMGTDSLGSGGLSSTTGSTGAYGTTGGAHPSMGHGTTSEFTTGDRNLGQNTSALGGNSTTSGYGGGLGSTGGFGNDRQTTGPAPNTAGPHKSDMLNKADPRVDSDLDNSKTIGGDKTFAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA61</accession>
    <name>A0A2T4CA61_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EXS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1420560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA61"/>
    <dbReference type="STRING" id="983965.A0A2T4CA61"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="679"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="874"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="969"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="998" mass="113815" checksum="F7421C7E97302167" modified="2018-07-18" version="1">MKFAKELEREAVPEWRAKYLNYKAGKKFVKAVASAIQRTSGSTPRLLTSRRPPSFFAVASPQTEPTPHPSSRLETNRQTDETPKSTRWHGQSEPVSIAKRVEEDALSSDGNSLQYGSFVPTPPGNPQTPSQEALQDDPDDGQQEERETSHKRNQSMGTDDFFELPAPAIHTTSSSPGGKRILSPSMKSARFDLHRSSSSGPLSSGTLPNLARRDSAEETLRRLSTARESARITGFPRQSLDLVREKEQQFYAFLDSELEKVETFYKKNEDRAGERLVILREQLHEMRNRRIQEIANERANSSLSRLSHHKVDETSADRSLSWMHPLKTKIFPLGPNSKALQDMPRTPHLLGGGGRASEDRMDYVRRPENDEVAYRTAKRKLKLAMQEFYRSLELLKSYALLNRTAFRKLNKKYDKAVNARPPMRYMNEKVNKAWFVNSDVLEGHIKTVEDLYARYFERGNQKLAVGKLRKMNKKPKDESGSSFLNGFLIGTGAVFTIQGLVYGVQLLNDDDPAVRLQTSYLLQLYGGYFLMLMLFSFFCVNCYIWLQNRVNYPFIFEFDQRSQLDWRQISEFPSFFLLVFGLIMWANFSRYGDDTMFLYYPVLLIGLTVVVILFPAPVMAHKSRRWFAYSHWRLLLSGLYPVEFRDFFLGDMYCSLTYSMANIELFFCLYANHWHSPGQCNSTSSRLLGFLTTLPAIWRFLQCIRRYRDTRNIFPHLVNCGKYTATILSYVTLSMYRIGQNKSDLALFATFSTVNGLYTSVWDLFMDFSLLQPQSRHTALRDILALKYRWVYYVIMVVDPILRFSWIFYAIFTHDLQHSTIVSFLVSFMEVFRRGMWSLLRVENEHCANVAQYKASREVPLPYHIEPLLEQSTESSPMLAAQGGARPSEGPQQPRPQTTERPGTYDSGTSTAVGVPPSGSLRHRAEPASPRVARGFSKIMAEAHKQDFEKKRRPADGAGDGAGAAGQGDEFDDDDDDDDDDPDGGSLSGMRPHSGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA86</accession>
    <name>A0A2T4CA86_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA86"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="73" mass="7926" checksum="B4941D72188B6088" modified="2018-07-18" version="1">MPLVTAALIAFQGTIVCHFANLIDCTDNSGSGLCGLTRTTYSSHLLLECLFFGFSLFSLIFSPDIIEVPLQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB97</accession>
    <name>A0A2T4CB97_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CB97"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="562" mass="62255" checksum="D4B5A90CA695C15B" modified="2018-07-18" version="1">MADKVSWHNQALPPVNSSASEIRILQIRPGPPTSPLQCNFLVTSLDNQVTPYDALSYAWGNDAPDSYESIFFGDAQIGVTPSLANALRRLRLPNEPRNIWADALCINQADDIEKSLQVSMMGRIYRQSTQGAIWLGPLKHTSPSDAQAALDTLSWIAGEQDPPPWLANEPKRTAASAALKALLNVPWWSRIWTVQEAILLPKATVYWGPCSLPWTTLDSASDSFFDGSAPAIHAEFWSNGCLLDLQAALRGLAASRGEDLFQLLWRWRYRRATDPRDKVYGLLGFRSDISLPSVKMCDYTVDVRTLYHNVTVDLINMSTDLQPLIGRGGEGSDIPGLASWAVDWSGVEDPSRRSRANFWDHRHWWHFGGFEADRGMYGVGEGLRVEDKGAALRISGLKLGRVTLVDESPADIPEGDSVASIFRSYGNRWGRLVSQYHQQFPNGLSDGGMTAFLGIIMGNLTPDGSNDRDDFNPWVTQMVRSQIIFVTDNGYIGLGPPNVRPGQELWIVGGCRVPVVLNPLPKASEQESDASLTFHSECFVYGIMRGEAVEGREDQVVEILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBL5</accession>
    <name>A0A2T4CBL5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1419390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBL5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBL5"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="517" mass="57917" checksum="C1442E6E35D80A1F" modified="2018-07-18" version="1">MQHHAPYGYPTPPASPAYDNLKCNVQQPFATRTFQPRCVPLAPEQRLGQLLEGKLQLTDILGTGAYGVVYTALDINTGVQYAVKCLSKYNADGTPLERRQVAYQQREIRLHYLASAHPNVVSMMKIVDDPDCIYVILEYCPEGDLFSNITERGQYVGNDELSKKVFLQILDAVEHCHNLGIYHRDLKPENILVTDNGETVKLADFGLATSEDRSEDYGCGSTFYMSPECLDPSARKPYYMCAPNDVWSLGVILVNLTCGRNPWKQASFQDSTYRAYVRSQDFLKTILPLTDELNAILGRIFNPNPEHRITLPELRKMIMACSRFTVPAVPTPHSTPDQYVSNDEDAIVDDYECDSALSSASSSTTEGSLASSVSTIDDLDTDEDDDDYMSVHQDLPQEYMSQAYESEELDAQQAVYHQGHEFVPQQYTGPVPVPLLHPHTHMVPPATPAAPLQHMPCQQASASIQAPIPTQPGYQLKSLLPFCVDMFKYVQHVQMMQPNHVPFHQQVSFLSPLHGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBP8</accession>
    <name>A0A2T4CBP8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1157408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBP8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="178" mass="19760" checksum="E214C7C695F95E38" modified="2018-07-18" version="1">MQPSPVDVCLKLPDIGMQDRIRTVVTCLAQPSSDIDKSHMPGMGPDTKRILLSIASYQRSHWASYDSMDHADGFAGCVRESPSASHVRRTKDSAFGHYPAAFHSPVSESVTVNTSHSTPCRVPACWIPNCSRKARVVSAYPGVRVFDVIISQSWNHVKFRGRTRKDFLQSACQWVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCD6</accession>
    <name>A0A2T4CCD6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCD6"/>
    <dbReference type="STRING" id="983965.A0A2T4CCD6"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="82791" checksum="AFF211F244B597EC" modified="2018-07-18" version="1">MHRAVTARLLRQALRVGEAAPSTGVPLYLCPAVAGLSSKLSSISLGATRSISQRRRNHTEALSSHAESNTTTPVPPQPIQKPVRRLPLTCSGCGAFTQTEDPNQLGYVDVSKRRIREWLHPVARRTAPAEGEEDKIVNAALESLDESRLKELGLDPAALLEGHEPESVPINSTIQPQHSLGIASLLTSTFAVTPYQKPPVCDRCHDLLHHSTKGGTAKVAMYHPTVESLRETIEESPHKYNHIYHIIDAADFPMSLIPRLNVLLGDIPLRTRNRRSRAGKFQHDRKTEMSFIITRGDLLGPTKEIVDSMMPYLKDVLRDALGRLGQRVRLGNVRCVSARRDWWTKAVKEDVWNRGGAGWMVGKVNVGKSQLFEAIYPKGRMGDKPQRASVATYPRGSPTAGMASDDALAEDENLATLNLGNLLPPPRPAENYPDMPIVSSLPGTTASPIRIPFGNGKGELIDLPGLARSDLELYVKEEHRQSLIMKKRIVPEQVTVKPGSSLLLGGGLIRITPRTPDMIFLMYNFTPLDEHLTSTEKAIAFQNQTHQSTGLENITLPGVGDKMKHAGTFKLDHDVTKKRAGPLTRKNAIGLSVDKLPFRVLSVDILIEGVGYVEIVAQVRTRTLERILESQNAPRDVERDTIPKEEPKDTSDPFSSMYNMRRDTAANDRATEPKVQLQLQPQESADWPAVDVYSPEGRFVGSRKPINGWLNNKPRELAEHKRSRPRRSMKGAKKLEKRRGRERQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCH5</accession>
    <name>A0A2T4CCH5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1164337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCH5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="97" mass="10327" checksum="56F40F017C522F5A" modified="2018-07-18" version="1">MLSNRIPRGWTRPSQSRGIDSISSSPTNPTSQRNLISDMTGSSGLLRGQSTAGVVQLIILPSAAASQMASPGQKPQRRGSARRCKHATTKHPTSIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCJ8</accession>
    <name>A0A2T4CCJ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1371109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCJ8"/>
    <dbReference type="STRING" id="983965.A0A2T4CCJ8"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="566"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="862"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="957" mass="106842" checksum="D605B793DFB55E4A" modified="2018-07-18" version="1">MDRPEPGLVKWSPKASIDSFVHINLQHRVVQLYEPTGHARAGRFDYAKVSRHDDFPPLTTYDWSPENPSLLAVGTGAGIVNLLRIDDSSNAYVELGLKMARTCQAVSFNTTGLLAVGLDRVRMDQSLQIWDVHRLSSVTSVGKGFVENWGTLSEPKRVEPSVSVSSIKFFEDSPQVLVAGIKGQGVRIHDLRDPTGVITFPTKCNNNLAIDYADQNYFASSALDHPGVMIWDRRATSRPVASHTYNQAVEEDDLPWGGALRLDTVVDTDSDSSMAEEKHSLIRSLRYCRDHRGLLAVLSRTGQLKVLDTNKESPSSDAVPHGGPELLKVQRSHEMDVSYRDNSRKNDRIVSFDWVTLGSAALRPRLLVLRANGGFDILEQSSRTADHIFKLVPWQAPHRGLEENTPYQDLMRFEATQASKMLAPVIMESNLSDVAIFGPDRVTIEAIVEKTLDPKTPISISVELANQISSPLPESFTKAETIAEKLRSLRNYVREESNASDTLAEGRPHANDVRRLNHGKPGSALISSNGIGSCTEIHEALLGTLASASGLPREAQVVVDHVKLFRAKERYLFDAVTNRNVISDDPWKRFVWDWIGDAERAADDGALMLSHMDLSYLGVHAIWTNNLGEQHVFPNLKTGRNPTTRLSPGAHVPDAYAWERSIGAYCKKHQLPKFDGVATKKPHHRQLCLEICGWGDDQNHDPSGLDREADPEYPAGIHTMAASRALFRGDTNLAIEILKEASQSHPELLFVSLALQLIGREGRQLPKERLEIDEAVASKTDPYLRAISSLIATGDWTIIANQPSLPLADRAYVAIRNFSDEQLTAWLNEQVLRAVAEGDIEAICLTGITDTMVDIFARYVEKFNDFQTATLVICPNCGRHLPRCILCYEVVGVPRSDRPEEREETRMASRFPTFCLRCEHVLHLDHAREWFARHAECPVPECRCRCSFRANPELNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCY2</accession>
    <name>A0A2T4CCY2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_236813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCY2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="188" mass="21420" checksum="79DF1C85CE16DFBF" modified="2018-07-18" version="1">MSTCSKGGASTQLRPRRREKKASARCHASSSTDGSAMLVLDSTSCKFSLYTSTSLCDYVFSCAILYECSIRLRRGIVIILYTPVVRLLRCIEPCRSLVTSHQIPMIPPQQEYFRKWCKPKSQRKKRLRALQLQCCSAYIPPMSQSTMLPVYRHQLLFYMYTSHVITKRIASNETASPPISMYICTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD20</accession>
    <name>A0A2T4CD20_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Map kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_48692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD20"/>
    <dbReference type="STRING" id="983965.A0A2T4CD20"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="193"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="492" mass="53242" checksum="8E1BE27778FB155F" modified="2018-07-18" version="1">MNSPAPLMRPAIPGSRGRAAPRLGLAIPPSPNAKPVGNLTIQPPARPPLPTLHLATPMGSQVTPVEQPARPQGGIQPGQSAGGGSESSAAHSRSGSFGPLDGRASNPTSAGSQFSALSFASQYGIPVTRAQGTPDPVSAVGSMRSEGGVSMERDGSLQGLEGFDRLSIEKARTADVEDLDDEGWRIASLEKRIVELGNLGEGAGGAVTKAMLKGGKTIFALKVITTNPDPDVKKQIVRELGFNKECASDHICRYYGAFVDPSTATISIAMEFCEGGSLDSIYKEVKRLGGRTGEKVLGKIAEGVLGGLTYLHTRRIIHRDIKPSNILLCRDGSVKLCDFGVSGDFGTKGEANTFIGTSYYMAPERITGQSYTITSDVWSTGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVRQPVPKLKDEPDNDVYWSDNFKYFIECCLEKQPNRRASPWKMLEHPWMVEMRSKRVNMVKYLSFVWGWDEKQVKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDN2</accession>
    <name>A0A2T4CDN2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-protein signaling regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1327308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDN2"/>
    <dbReference type="STRING" id="983965.A0A2T4CDN2"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="213"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="336"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="504" mass="56834" checksum="1FC4C4DA8F3A3243" modified="2018-07-18" version="1">MHQTSSRLLRMTDDDRPFTRDFKDLFSTLIVSLLPLGSHRVRLTKVDYTFLSEDAINNLGSLKFSQSNRMPDPKDPSRIVTTTTTTTFSMAKDMARSICQRFVEARFIESADGKMQPVYNMKGSVWQLTAKGVAILDRFCARNGIQQKQVAELVNLHCCSLVILEREQHSDKILSDRGTVEVIFRRFVGTESRNVKPNVAAADSDSLHDYEDGLTGVKMANERRVNGKVYKDTFTGKACADWLIDCCTIVDKREAIEIASLFVEFELIETVVQDRSFMLQNPGCHLFQPTKYSVYQISQRGKDVINGTSSRGRPSESEAGTGSQRNGVVRDSNTQRLEKILNDPALRLLFRENLRETHCEENLSFYKDVNDFVQSCKTAIRQAESAPSGTSMDIIKEIMAQAYGIYNAFLAPGSPCELNIDHQLRNNLATRMTKAVGQENGMIETLQEVTSLFETAQNAVFKLMASDSVPKFLRNAKYEQQLQNFNLDGSSRGVERSLSRSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE55</accession>
    <name>A0A2T4CE55_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1372092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE55"/>
    <dbReference type="STRING" id="983965.A0A2T4CE55"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="233"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="715" mass="80293" checksum="A42DE38FA7F85796" modified="2018-07-18" version="1">MPVFGEPSVDDLSSDPTQRTRWSYASSSDPPLPDEDATQPFCPRHAVTIARLDRDSFGPHPMKASSITPHRDWHFGNLDYVLSRRDWCRACGLIAAVILEDPSNSILERQNAEIIACWIWDGVLDGSHSDVGTLRLRIAPEMVGWESLFEPFDLVPLADADVEDNKLFLGRTIKETQFDLDLVKRWINSCAEWHGGECLDTTPWQTLDLGVSFIRMVSLKDCKLIETSCPPPYVALSYVWGSAPVFKTTLSNISDLMQQQGLPVSSLPRSIRDAMSLAQELGFEYIWIDSICIIQDSGDDKAQQLRMMDSIYTRAHLTIVAAAGSHANAGIPGLQPETRSRKQHIVQVSDSLSLVALHPDTHRSAAATTWSTRGWTYQELLLSKRCLYSFPDGSVSFQCSRAVWGEDYHAETPHLKRCAPMLDISLNRSWMSPGGVRERGAPTVHVKDTPYLHEYSRLVEAYTGRNMSFASDRLAGISGVLDVLRREFSLYFLHGLPEVLIHMALLWQPRNKLKRVPNDASTGLPLYPSWSWTGWTGPVGYEDWNAFNSMPELDDRAKRVIPLAKLAKPPFLSLRTRKAIFRLTNLVLSPDFSKDDFPIEHRGRFGLALPSPATGDRPWLGTILLPVQYLAKMARNHEFIVLSESYGFSRQEVSPTTAGQMEPFEAYDVMMIRRVAGEELANWLDGKSVVERIGVGRMLKSAWSGDGGWEDFVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEI8</accession>
    <name>A0A2T4CEI8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEI8"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44905" checksum="F9542C30CF22B857" modified="2018-07-18" version="1">MLWLGSNVEEMMEKIGKPEGPTVWSFMLWWFFLVLMCATQDIAVDGWALTLLTPGNVSYASTAQTVGLTAGHFMSYTVFLALNASDFANKWVRTTPSDDGLVSLGGYLTFWGWTYIIVTIGLGLLKREEKSQNEDGVWDVYRIMWGILKLRNVQTIIIVHLIAKIGFQANDGVTNLKLLDKGFGKDNMALTVLIDFPFEIGVGYYAGMWSQKYTPMRLWCWGFAGRLLAALIAQVTVAMFPAEGVTTWYLLVVILEHVFSTFTNTIMFVAISAFHAKVSDPVIGGTYMTLLATVSNLGGTFPRYFVLKLVDSFTVATCHPGSRSTSNLKGPLVTEPFSCAIQGEKERCLNGGGSCEMIRDGYYTVNILCVLFGVATFIWYIKPKVLHLQSLPLRAWRLAGSGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CER7</accession>
    <name>A0A2T4CER7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1324853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CER7"/>
    <dbReference type="STRING" id="983965.A0A2T4CER7"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015517506" evidence="4">
        <location>
            <begin position="20"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="110"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="229"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="350"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="616" mass="68641" checksum="22568B4FE72B83C9" modified="2018-07-18" version="1">MNLFPAGLLTLVCVGSVIAQSSSPASYKVQKPPLDTDWTYKVGTDPWPEYPRPQLQREAWQSLNGIWTFQPAQAGAGDSGSPPGAPLQSEVLVPSCIESGLSGLQIMNITDMWFATRFKVPHSWSGQSVILNFEAVDYQAVVFVNGARAGNHTGGYFRFGLDITEFVKFGGENDLTVFVHDPTDMDVIPIGKQTRNPSHIFYRSCSGIWQSVWLESVPSNHITQLDVAAGMDGTVCVTVHSSNKQGASAKVSVIGLDGRTIASHKGPSDKEFKFKVKHPKLWSPSSPTLYNLTVTLGEDEVSSYTGFRTISSGLVKGIKRPLLNGEFTFMFGTLDQGFWPDGLYVPPNREALVYDLKMLKGLGFNTVRKHIKVEPDLFYRACDEMGLMVIQDMPSLTNDGNRPPNPDQQAEFQRQLEVLVNEHKNYPSIVTWVIYNEGWGQLRGPPYPEEKLVEVVRSIDPTRLIDATTGWNDHGAGDFSDNHHYANPQCGTPFYSTPSSPYDPKRIGFQGEFGGVGHNVSIEHLWNVQEAINTINQTYEVDADLATYNYRASVLFREFLEQVERYACSGGIWTQTTDVEGEVNGLYTYDRRLLRPDARQWKSDVRKLYAAAAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFM8</accession>
    <name>A0A2T4CFM8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1325318</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFM8"/>
    <dbReference type="STRING" id="983965.A0A2T4CFM8"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="878"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="630"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="753"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="896"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB80369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="920" mass="102355" checksum="624990F1ABC054EA" modified="2018-07-18" version="1">MSNNSIKVVARFRPQNRIEIESGGKPIVTFNSEDTCTIDSKEAQGTFTFDRIFDMSCKQQDIFDYSIRPTVDDILNGYNGTVFAYGQTGAGKSYTMMGSNIDDPEQRGVIPRIIEQIFASIMSSPSTIEYTVRVSYMEIYMEKIRDLLAPQNDNLPIHEEKNRGIYVKGLLEIYVSSVQEVYEVMRRGGSARMVSATNMNAESSRSHSIFVVTITQKNIESGSAKSGQLFLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGKSHYVPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNDAETLGTLRFGTRAKSIKNKAKVNAELSPAELKALLKKVQGQVTNFESYISNLEGEVQLWRSGESVPKEKWVQPVTDGIAAAKAEARAPRPSTPSRLTESRSETPIASDRAGTPSITLEKDEREEFLRRENELQDQIAEKESQASAAEKLLRETKEELSYLKEHDSKMGKENERLTTEVNEFKMQLERLNFESKEAQITMDALKEANAELTAELDDMKQQLLDAKMSAKETGAALDEKERKKAEKMAKMMAGFELGTDVFSDNERSIAETIKHIDALLEQSTIGDHIAPDEFKALRAKMVETQGIVRQAELSMYSGPSNDLDARRRQELEAKLEALQQEYEEVLTRNLSEADVEEVKARLEAVYSKREKSEVELVEELKADLAQKASENARMKTLIEELQQRVKAGGAGAMANGKTVQQQIAEFDVMKKSLMRDLQNRCERVVELEISLDETREQYNNVLRSSNNRAQQKKMAFLERNLEQLTQVQRQLVEQNSSLKKEVAIAERKLIARNERIQSLESLLQDSQEKMATANHKYVQLASVKERLEAAKAGSTRGLGGAGGGFSFTNAGSRIAKPLRGGGGDTPATPTIQGGDGTPTSSKRGSWFFNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFX7</accession>
    <name>A0A2T4CFX7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFX7"/>
    <dbReference type="STRING" id="983965.A0A2T4CFX7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18833" checksum="416AFD53E22FDCE5" modified="2018-07-18" version="1">MAPKNNNRGENPPAYGEPPQVPEAAYGGYGGYAGYQQQGQPSNYQQGFQNPQSQQQAYYQPGPQMGYYNQQQGYSQGQYPSGYNQWPQGQYAQGQYGQGQYGQYPPQGYYGDRRPGGTTSGLLGGLALEIGKPITQMIPLWIRFEWWMRSFGYQGRFLWESHELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGJ8</accession>
    <name>A0A2T4CGJ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1428318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGJ8"/>
    <dbReference type="STRING" id="983965.A0A2T4CGJ8"/>
    <dbReference type="OrthoDB" id="4900214at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="335" mass="36678" checksum="9CDCF9E2E372BC72" modified="2018-07-18" version="1">MSDPSRYTVGWICALPTELVAAKAFLDEKHQPPSYVAKHDTNSYSLGSMGGHNVVIAVLPKNETGTASAAIVARDMVHSFPNIRVGLMVGIGGGAPSSEHDVRLGDVVVSMSEGAQGGVFQYDFGKTMQDQAFRYTRFLDQPPTVFRTTVNQLSTDMKFHRKMLEEAINDVLKASPMLRPDHHRPAPESDRLFRSDVVHPPVGGSCAQCCPADPSTMVARPARKVAKYSPAIHYGIIASANQVMKDAMIRDKLVKENNVLCFEMEAAGLMNHFPCLVVRGISDYSDSHKNDEWQGYAAMAAAAYAKALLRRIVPSQVEEVERIGKLLAQSQFFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH10</accession>
    <name>A0A2T4CH10_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_69756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH10"/>
    <dbReference type="STRING" id="983965.A0A2T4CH10"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="182" mass="19776" checksum="D146A92E9A78ACC0" modified="2018-07-18" version="1">MIAASVPNSEPILNLLLQRGADVNIKNNNGQVSKSNITTPFLQRHTPSTPQAYPPVKRLTQPPLQSALHFVASKKNLDVARLLLAANPPASTRVRDRRGQYPIHRAAAVGSVPMVTLLLRNRSPLNAADGEGFTPLHHAVAEGHDFTLKNNDGELAIDLAPDQEVRHFIIQGAEREGISLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHB9</accession>
    <name>A0A2T4CHB9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1002519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHB9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="206" mass="22974" checksum="A5E888C0DB750154" modified="2018-07-18" version="1">MGGYRDVGSTTSGRRDQAVVLLHPYLGTLGMENHHRVTWISPQILSLEMHHLSCFFQLFQLPGYKTTRQAQPCMSAGMPVKHTGNLSGMTNSAGFPLWIILDHLLHRLSPQAIVQAQTKPTRRTCCCWSPAVWRSAAACAKRHHQQRREVNLSQALEDILIPLDPRVGSGHLQRRFHLHPTSCCCWSQLLASLSRLAVTVAVPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHW3</accession>
    <name>A0A2T4CHW3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1008394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHW3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="23803" checksum="09C0BA33789BF966" modified="2018-07-18" version="1">MDHLPPLHQHPSLAHGAKFSDSKAKAGSQFLRPATLHLKEARRAWPHASLQPLPGQMAAMGRKKGPPAIGLVASLPHMLCFAVLSDGVHVHSLPSDRSASPRLQVCDTYRFFSFALFSMGIWTREQNRLDILLLLAGQLEKVRGRNTAGPARSFLTVGCFEGHLSERLYKATLRHQPRSSRRYAPSTEYKSRCRCHAIWRKPHCCTPSLIAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIU1</accession>
    <name>A0A2T4CIU1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-terminal binuclear Zn cluster-containing/DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1323099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIU1"/>
    <dbReference type="STRING" id="983965.A0A2T4CIU1"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="213"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="581" mass="65521" checksum="BA863B4C80879EDD" modified="2018-07-18" version="1" fragment="single">GRLHQDIIKCDRKRPCSKCAKAGTECVLQGIGEKQRWLRVLTTRRPVSKSYVQALEGQIAALETVIHKLALADDAERTQIISDLSLTSGAPSVPLLPEAGPADAKTDPSLAAARKMMSRFFQEVYPYNMVVYREYFLRDYDVGSGKYYSDVLFYSICALGALQCDDMLNLSDVFAGQAQTLLYSMLDSPDLTVLQALVLLGYREIAVGRASKGWLFCGMAFRLAHEMGLHLDPTNWQGPTPHETSGDREILRRVYWAVFIADKQLSLYFGRPPALYPSESDVRNTIRLQYPPGWQGLLETYICKGASANEWDNGVSLVGSFIYRAELAKIIHLIITDLFENRRGGADPTIIATKTRRIHVLLTRWLTNLPSSLHWNQWTVGQVPPYVLHLHMMFHTIMIILHRPPSHMFENPGIAESEDVEICYESLQAILRLMRSYSRYYRYRCLPLDFVHTLSTAASTVMMKRFLQKASWSDPDIERALSLVMQAMNEIQHTWPCVREIRDVVMQAQQTQATMPPEDPLNAPGLMNGLEGVAGHDGFLANLGEDVDIGTLITDEFLSAQVPFLEEGLEPFDFNQFPGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJX6</accession>
    <name>A0A2T4CJX6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1388156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJX6"/>
    <dbReference type="STRING" id="983965.A0A2T4CJX6"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="72"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="239" mass="26527" checksum="9DFFB4DA3ACD65C0" modified="2018-07-18" version="1">MSSTDAATEPKVEQTKTEAPSVTSSSVFSMFGGGEKKEKKEDEDRGDNSGSAKAQREAKAEEDEAPESEDVHFEPVVKLTEKVEVKTNEESEEQLFKMRAKLFKFVKAAKKEGEEAPAAAGEWKERGTGDVRLLKHKETAKVRLVMRREKTLKVCANHYIVPEISLSANVGSDRSWVWNAAADVSEGEPEAVTLAIRFANSDNANQFRDAFLKAQKESAHLFKTSEEKEEEAEEEKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP27</accession>
    <name>A0A2T4BP27_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_9276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679161">
        <property type="protein sequence ID" value="PTB71062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP27"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="18144" checksum="17EEDCF89BB432EA" modified="2018-07-18" version="1">MPPVSSCANTVKQYYNLEEEEEEEEDREEEEEEDREEEEEEDREEEEEEDREEEEEEDREEEEEEDREEEEEEEEDREGGGRGVAQPYCSSFITGLVTEPAQSISTAAASRWQHGLTLVIIVAQGPRSRSRSQKQGILPVVYKFTIAQPATQRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQZ4</accession>
    <name>A0A2T4BQZ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1473316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQZ4"/>
    <dbReference type="STRING" id="983965.A0A2T4BQZ4"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015548769" evidence="6">
        <location>
            <begin position="21"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="115"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="587" mass="64039" checksum="2F00A6614FF05117" modified="2018-07-18" version="1">MLAFSLRLLLFLAVIGSGLCAPQTEICKAYPGTASWPPAHAWASLNRTLNGRLLRPVPPGAVCHPNQPSFNSSQCAEVAAAWKTYEFHVESPISVMWDKFDNFTCLPEEDTPCSPAGYPAYVVNASNTEHVKIGIDFARKHNVRLNVKNTGHDYLGRSNSPGSLSIWTHHLDTMTYNKGQYKLHGSGKVLLGNSVTVGGGSEMYNIYAAADKYNETIVGGGGKTVGIGGYITGGGHSVFAPKYGLAADNVWEMEVVTPGGYIVVANEDQHRDLFWAMRGGGGSTFGVITSVTLKTHPSPKILGLLYGIITDPQETIVYDLITYILSQTPYLMAQGLSGYNLITRDMAMPLQLPGAPDRVAGFLGSSVLQDVDSPEAVAALFKPLNDTIRKRWADKAQFYVLPTAYDSFLAWFDNNYDTDPAGESQYLVSRLLDGEALTGNQQKLKSALEATLASSGTIAAFMVGGKGVHDAKPRGGSNAVNPAWRSAYLHTLTSQSFGPFNKTAEEDAIATLDSEFQPLRDLTPKSGAYINEAFPFEKNWQETFWGSNYARLLRIKRAFDPTDVFWCSPCVGNERWEVRQNGKLCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR08</accession>
    <name>A0A2T4BR08_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1139750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR08"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="13880" checksum="CE09B32195D03927" modified="2018-07-18" version="1">MNNISSPNHASHPSPHKLSLPLISLLLHLPTSEAPRLLVSWSLHWPEAVADTELKSSYAFSHRLQHITIASSLACRKTILCQKAPVKRPTKEPRTRRIIGQVEEGGGHAKEKVECGRETRQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR39</accession>
    <name>A0A2T4BR39_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1386138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR39"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G00100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="273" mass="29993" checksum="A158CA168F1B8618" modified="2018-07-18" version="1">MTTDGLSAAKLALYLILIQPALFCLWKHGRTGFLGWFFVQIFSILRIATGGIGLHGNAKGEAALILSSIGLSPLLLGISGILYEGRRAVNPRLDRKRDITLELGYHTIVNLGMVLIIVAIVKIMKGDLEPKYKALLYLGLAVSCVSWGLVTLWAVWSYLMARENSSYASMQTVDNGKILIKGVFVALPFVAIRLAYGVVSLHLQVTHPSSGFLTSEAVQVCLSFLPELICITILVFVGVVTRSLRSDLKKREQETIGLVSDQENVLQQQTEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS34</accession>
    <name>A0A2T4BS34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1364246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS34"/>
    <dbReference type="STRING" id="983965.A0A2T4BS34"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="326" mass="35849" checksum="D0AC0222DFC1EADA" modified="2018-07-18" version="1">MGSVSKPLLVFGTAGVNTGGAFPTAEQAAELLDAVEKVGIKQLDTAQLYGLSEQILGELKAGERFTIDTKHIGGWTPGESTREKVVARGLESLRKLGVDKVNIFYIHAPDNSVPLEETLAGIDDLYRQGKFERFGLSNFNADEVRAVLKITKEKGFVAPTVYQGNYNAVARKLETDLFPLLRENNISFYAYSAIAGGFLTKSKEQLLQESGGEGRWSKKTVVGEMYHKLYNRPKVLKALDLWSETAAAAGIPKAEMAYRWTAYHSALKEHLGDAMVLGASKISQLQQTVEGLGNGPLPEEVVKKIDDIWELVKDEAPTDNFEVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSE4</accession>
    <name>A0A2T4BSE4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polysaccharide lyase family 7 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSE4"/>
    <dbReference type="OrthoDB" id="4221926at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33681">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33681:SF4">
        <property type="entry name" value="OS12G0171100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015642551" description="Polysaccharide lyase family 7 protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="21651" checksum="FFB86ED64A082C01" modified="2018-07-18" version="1">MLVKTLLATLSAATAVFAATPLESGNWVSVNPGFQTQTCEGGSVSGTTFTIPTSPNGNNSGAGCSNGHLRAERRYTNDYSSGVHQFAGTFKINSMGGSRIAIKQTFNGDTGPYFILAVDTGGRLYSVEGGATLATGVANVGSSVTINTVHNADIHSYRVYVNGKLAFRDDNAPDGSFYDKFGAYTTDSGTGPMSITWSDVAFWTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT74</accession>
    <name>A0A2T4BT74_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1425633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT74"/>
    <dbReference type="STRING" id="983965.A0A2T4BT74"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB72513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="323" mass="36035" checksum="06E91D5AC9EBA349" modified="2018-07-18" version="1">MSGGWNTIESDAGVFTSLIENLGVKNVQFEELLTLDPSELLALQPLYGVIFLFKYPTDQPYASIEGPQDGTFDHDASERIFFAAQTIQNACATQALLSVLLNKDSGDGDDDVEIGPQLKDFRDFTMVLPPEFRGEALSNSDLIREVHNGFARSSPFADETARQHGGEPSEDVFHFIAYTPIQGTLYELDGLQPAPISHGPCAPEEFPTKVVDVLRRRVARYDEAEIRFNLLAVCRDLRIRAREFGDVELLERENRKRADWAFENALRRHNFVGFAGEVLKKVVEKKLEQGGDEAVDRWVGESLERRRAAEKARGGGGDVDMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTA3</accession>
    <name>A0A2T4BTA3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1384561</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTA3"/>
    <dbReference type="STRING" id="983965.A0A2T4BTA3"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="434"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="144"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="259"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="411"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="528"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB72528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="730" mass="80405" checksum="6642DD413ACB0395" modified="2018-07-18" version="1">MSNDTEGAAAVAAVAQSSGPDADAGGNKFSHAIAAWRNVDLTNLISNLDNTASEIVTYQRDSTVQRKDLAQKTKDFRKLDDATKLTEIKGLLKAYQGFIDLLTNHSKSVNSAFLKAYSSLSEAPDPYPLLEASVDSMLVSEDTLPKVTEENQRLQKSVAKLTTQLEESESRLQSERAARKELEDQLESKVKEVEASWTAVLDEKKDNWEAKEKTLEEKIANQERLLSEVKANYEVSQRLGKASGDDHDGQRTQALNAELEMLHADLERTSSRLAEVEARNEQMRLELAQAKSSQQTQSISLEDDPGYMRMRSENSSLVRKLEAARVEKEGYKRELDSKLRSVEREVALLREEKESLKAKVDKWADYEEVKQELEVLKSIEFSTGDDDEAAQELEGVASKGDTLEKLLLARNKKLNDELTILRVSHQDLQRRLEDIQEELSRTNAELEKAQNLNEKLESDLESLQAEGANAFPSGASVAGTYITRAQGRKGRISPTSSIISGIDPRTAPGEREPMGGGSGILPMVAAQRDRFRKRNAQLEQELSESHRVVQQLRQEVAALQKDNLNLYEKTRYVSTYSRGGATTSSSSAYATNPNPSTVTIGGSGSPGMELDRYRKAYESNISPFAAFRGRESARAYRRMSLPERVVYSITRMVLASRTSRNLFAAYCVALHVLVFFSLYWLGTSDLERHASNLGSSAAAAAAGGASAGGGVGGGVAGGGHSEWQEDGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTB8</accession>
    <name>A0A2T4BTB8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1092063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTB8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="86" mass="10526" checksum="FAB808D9DB645C2E" modified="2018-07-18" version="1">MYLWYDILSGSLVMLTDYSTFLVLSLHASSFWMLDLGVSLFWRDERVSFSLHQFHSRNVFTLNDNEHYIRLHIYYQTYIYPVHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTH2</accession>
    <name>A0A2T4BTH2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1433428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTH2"/>
    <dbReference type="STRING" id="983965.A0A2T4BTH2"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="535"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="958" mass="106926" checksum="17D4D990C6D1D2A9" modified="2018-07-18" version="1">MAPTLKVALVQFQGKDGKAAEAIIELHNITYFIAAATGEILGAYQKKNLWHVERGVLTADQKSPHKAFSAPLLGSNYVNPTSNSRLDTAMEPSAGSRHDASPSPSHHLGVTRRFAHAVASRLTRRRYVGNIVSRFANRRFAFAVATVSIFSAKGVHIYTHLSSLPLVHLVRWGYSFFAQDVTLLVLVRLLLDPWLTEGSGWLRTATMSLASIIITYLITVGVVTVTFFAVCGSEIHWRNIGLAGDASSFAMFLSGLASLVVVLFTVLFVACIMQDICYVAAGIATDILKWPISFALRRSSSSAAAYSQVPQLDVELANAFDELEDEEEFCNLKSKTSVTILRRLLYLFIGCALLTHVILILIRPNESALNFLSWTPALLPFVDFTFSSPSLDHLEPIYNTGIGRSWDNRTALTDPVSFPWLPRRHIPGFGDWYKNHQHYNAAADPLKISNLQDSLLPALEDKLADVPIRHVMLILLESTRKDVFPLKKDGLIWNRLSNSYSNGTLPEEAQAMLASLTSNANYITGDYDDGFEHESKKKRGGISFSNALTTATYTIKSIVGTMCGLTPLMADFNLEYLHHFYQPCLPQVFDALNKLDDDDVDADADKESAKDFTSFKWHSSFLQSVTKNYDRYVPLMSSMGITPDNLVSKEYLRSRFAKFGPVDLPDINYFGMADVAVEDYIRDAFVQAKKNNERAFVTHLTSTSHHPFAIPAEEPYTPLGSGLDDISHYINAIGYDDRWLGKIMKILDEEGVADETLVVFVGDHGVSMPENNILAPYYNPNIGTLRVPLVFSHPKLPAIQVDDAIISSQILPTILDLLRETGSLSKSQTRAASDMVQNYEGQSLIRPVHTTNNETGQANWQFTVVNPGRAMLSIRDARQPDWHLVVPIIDNVEWQFTNLMKDPTGAHTLLGFDFVNFMYSVENTHGVDAAKWVEEAAFMARWWVEENGKRWRYGPYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUT4</accession>
    <name>A0A2T4BUT4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUT4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015653582" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="102" mass="11018" checksum="0A5FF7C2AF723508" modified="2018-07-18" version="1">MVLVLVFYSCVCPRLVRLLYETEVLSQDISRVGSISAIVASSLDVRNPVCLDVDVDADGCPGAAIANRGALYSIDLDWGSLTEGLQPTRRWTRECGLASSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV59</accession>
    <name>A0A2T4BV59_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV59"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="218" mass="24485" checksum="18B61F1783F7949F" modified="2018-07-18" version="1">MRHLRDRPTTEPEASSLLPSDTSYKPQISSRWTKLQPPMFKSPKKRRSSIEEKKSHAEPAIRRKKKHTSPKRPISPFQGYVGSAPASVRTSPACIVNTCNFASEQKKQNQSTVWFSGAWRERERGAQTHAPLSPIPILAGDTLDRYLVGGPKYLAGREREQGGSGLAEKSLRQIERAEEREAMCWHPSVLLLPACPVFEGCKGRGEGPVQRFSTIDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV88</accession>
    <name>A0A2T4BV88_TRILO</name>
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        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1076037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BV88"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
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    </dbReference>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="185" mass="20035" checksum="DDEC4381EAC327E1" modified="2018-07-18" version="1">MADFAPPPGPPPPKAPEVPAGWVARWNEQYKEWFYVNIYTKKSQWEKPTSPVYPDNEAPPSEPPPGYDGHNAPHVSDTKKNPYGDHHSSDFAGSSSSRSAQEQEDARLAAQMQAEEDARARARGGGSGSQQQPPGYGYGGGAADSYRQQSTSPYPPPQSSPYGTPQPQQQQQQQQRGGGLLGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVS5</accession>
    <name>A0A2T4BVS5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nineteen complex-related protein 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1424728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVS5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVS5"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51227" checksum="041AEAB4A52F26F1" modified="2018-07-18" version="1">MSSFGVRRKAKVIKVDYDEDESSGDAPPAGDNGSLKDDGTKPVFSSKINRKPLRQSGLRNAFHPRDEETSGDRDEASQGNDEDDDGPVVVRPSTNRAGALKQKKKIAISKVSFGDDAGQDDDEPSSDFTTPKKPAMGQKGLEKNSIKRGMAARKLPLPVRSFQDDDDRPRYSKEYLDELKSSTPNTPSDLSSLKATLDDEMELDPSELEGALIVDSPIPSSVSQPQTTQILTEAEIRERKERRARLAKEKDFLSIEDEDDGLSARKKKDETRLVAEDEDLGEGFDEYVEDGGLSLGKRAEKERRKKDRQKMAELINAAEGHTSDSSSDSDAERRIAYETAQTRAGLDGLKKPKKDPNELLLQVPSKITPLPSLAECLVQLQATLKTMEANINTKAATVAQLTRERDDIIQREAEVQAFLNETGKKYEEALGRKPTSTDGVAGALAGERGLESLGATPVNEVHMEDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVT5</accession>
    <name>A0A2T4BVT5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1441058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVT5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVT5"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="83" mass="9341" checksum="045A9540C283FAB7" modified="2018-07-18" version="1">MAPAQPELKKYLDKRLFVQLNGSRKVIGVLRGYDVFLNIVLDEAVEEKDGGEKIRLGMVVIRGNSVVMLEALERIGGDDRQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVU9</accession>
    <name>A0A2T4BVU9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1339626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVU9"/>
    <dbReference type="OrthoDB" id="3492129at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="354" mass="39955" checksum="433735AA79653746" modified="2018-07-18" version="1">MRHRSSAHRVSKHSAAAELERRRRYSAVGPRDQWPNLAIAENRRRGNCVQYQTRPWFLPPGARRSDGTLVSPPPTPPLPGLSEAELAAWRRKRQLEEMRDWQVFLWGRGWERLGRIDDAHVFVRALPLTGTRNPTASTTSEGPDVPTSSLSSPTSTVPRRLSLRAIVHSGTNPPFGLRREFDLDALRKTIPEPHHLENWSVGARRKFHREEWMSKVQLSSDTRRASWPGAASAPISKDPEAAERKAERMAARMDEPETPVRPRGLQSMGVPMNLDYARTCLPALAAIIMSDRVKRGDMIDLAMPQPEAWPETVAYAYTGSLAFFSNATKENVIYLGGKLGKTRDMWSARRTYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW27</accession>
    <name>A0A2T4BW27_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1064099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW27"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="15708" checksum="1E752BD84833F443" modified="2018-07-18" version="1">MLAHDMIYGVIVDENHQEHDARASVPACSYTAAARYPRRIRIRQAMARYSSNHFIDKHPRQNQEHQHRRTPAPYQGTTRQPSTRIMQRLTCTVSHPQSMSEITPTQIAMTSRIAQQHPPCKLNEEKKQGETCQSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWB8</accession>
    <name>A0A2T4BWB8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWB8"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="265" mass="30096" checksum="89A8B22E2DC2F114" modified="2018-07-18" version="1">MPPTIHLVRHAQGYHNLSPENETLPDPDLTPLGLEQCSSLRASFPHHDRLRALVASGMRRTLYTCLHAFAPSDNDNDLNNSNNKKKSLLPVIALDTLQEVSDAPSDTGSSIAKLKEEFGEKVDFSRMREGWNDKTEGSYFEPTLDKLATRARDARLALREIAMAAGEGDDDDAHVVAVSHGAFLHFLTEEWHGITSTYPTSWTNCEYRTYQFVDPTGQDPDAQLRETDESWRRRHGSLKVPSEEEQRELRQMMVRELSPFFKTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWQ8</accession>
    <name>A0A2T4BWQ8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 10">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1051427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 10"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWQ8"/>
    <dbReference type="STRING" id="983965.A0A2T4BWQ8"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000001">
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    </dbReference>
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        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF51">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
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            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="123"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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            <position position="177"/>
        </location>
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        <ligand>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB73757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="291" mass="32728" checksum="78961875EBCE481D" modified="2018-07-18" version="1">MLPSRIGGQSLRLAVSRPSSLIFSAARRPAAAGSRYCSSSSSSSSSSNTPSGAASKPHAKAPARLPGMPEHDHDVERYLRENHQRLFENNRKWAAERLKQDPEFFTRLSAGQSPEYLWIGCSDSRIPAEAITGLGAGEAFVHRNIANMVISTDLNVMSVINYAVRHLKVKHIVVCGHYGCGGVKAAMTPKDMGLLNPWLRNIRDVYRLHEKELDAIPDEKKRYDRLVELNVFEQCRNVIKTADVQYSFEHNHYPIVHGWVFGFEDGLIKDLQIDMRKILGDIQKIYNLTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWT7</accession>
    <name>A0A2T4BWT7_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M440DRAFT_118977</name>
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    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        </location>
    </feature>
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            <begin position="86"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB73725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="12633" checksum="5CB2B800689F92BB" modified="2018-07-18" version="1">MQVMMPLIHTHGSIEPLPCLFATSLLLLVYKNGTSLTAGQAREFAVELQRRVTNSRNPTLDLLPIFVAKPVSSLPSPSNTVMRSQGRRDIWPDRKQYSRRSALTHVRYDTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWU5</accession>
    <name>A0A2T4BWU5_TRILO</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="ORF">M440DRAFT_364872</name>
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        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Chenthamara K."/>
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                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        <location>
            <begin position="298"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="385" mass="45118" checksum="1F03AC3371B17FD5" modified="2018-07-18" version="1">MAPSQATEDYYKFLGVPQTAGTDAIRASYRKLALKYHPDRNPNNPQATAQFQLLEAAYSTLFDPERRRIYDLQYESIKRNSATDTNKNPPPPQANSSEPDQLYKTQMAKLEAAIQQLRNREDELARQLAKARADRDTSWRALERLQAVADMDAKEEANRNSWYGYFFSSRQSEEEKQVRQRRMVENRVARTVREAELKRLTSRVATAQSLVEDIQRRVQEKEELAERLRKAQEAERVWREQEAERRKAQEAERRRAQEAERLRRAQEARKYEEDWDDILRGFREDIRKKTSYTEEARQGTSQTKARGQRSQRGQGSNAGNSTGRQSTKAPEGRKSSCLHRSWWEKEDGRHECERCLDTTRRFAFRCPSCRMVACAGCRDILKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWU9</accession>
    <name>A0A2T4BWU9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1299197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWU9"/>
    <dbReference type="STRING" id="983965.A0A2T4BWU9"/>
    <dbReference type="OrthoDB" id="4900387at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="73" mass="7998" checksum="BDA84ADD8CAAA755" modified="2018-07-18" version="1" fragment="single">RTSLSYASMAGRTSTARYLLDKGADIHVKDDEGNSSLIYATLYAHQETIKLLIKRGADVRAKDSRGKTPLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXA7</accession>
    <name>A0A2T4BXA7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1432737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXA7"/>
    <dbReference type="STRING" id="983965.A0A2T4BXA7"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="726" mass="78489" checksum="13A1BDD7578BCB8F" modified="2018-07-18" version="1">MPRPKVHPSQRQRAAEACNFCRTSKKRCSATVPCTACQRRGIGDSCHLTHRPRGSRAAAPPLPYPPRTRASAPEQVPASPGGGDGGIPDGLGGDASMEETAWGRTEFGDMNAPEWCSVNGDDAEGGYRPLTPSDSRVSASEGVANRSARLSRARRGSPAPEPESHARMLLNLRGERVYIGEAASLSFLQLIRDTVTAQIGPSQFSHNEKRDSMLETESAAAESSGLGTTNCNIDLEGSLLYARTFEAATGGLLDVFGPTEVEDLLMTIRTDEAQSLNPCQRASIDLAIAIGAQCKSPMEAQQVGPAYFRQAQQRAFAGMLEDPNVDMVRAFLLMAFYMLGHCRRNTAFMYLGIAARAAVALGMHSPHSYTDLGNPACQQRLHIWMSLCVLDMLVSSILGRPPATAGLRADLDATVISTNSSSATRHGPRTIGVFASYEILTIINESVDALYGRKVTSTAMIELFLSKIEAWSKQLPSYLRNPLTTKRDASAQKAATDSIHIACLYYFAITLVTRPVLISRLTSHPDVASPSSSPLASACLDAAVYLVQTCSEAHKSGLLLANMCILKALIFAAGLILGFDMFAKKELDYEVEVAFRSAKDVLDYLGIQSPQASHYSEILGLLSNAIMKRRMELSSRPRSRYVGKLLSLNREADIGQGDGAANEEALAPDGYASGTSITTRDIDEVWGAEISNQTAELDGDVLRGWDGLELSQWDSFPFFNPRVFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYE3</accession>
    <name>A0A2T4BYE3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1403654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYE3"/>
    <dbReference type="STRING" id="983965.A0A2T4BYE3"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="401" mass="44029" checksum="302E4B5C33627610" modified="2018-07-18" version="1">MRKPLMRIPYTDILPSPKIIPPSAHSLQGALAALHNFFAAPPPKPLPSSTVVLTGAGLSVASGLADYRGPNGTYRVNKTYRPIYYNEFVQNHEARKRYWARSFLGWTSLQKAKPNAGHYAIRDLGGLGLISAVITQNVDSFHPKAHPHIPSLELHGYLRSTTCTTCRSEYPREDFQHQLARLNPRWADLLQEALASGALDTEDPDEKKFRGLKVNPDGDVDFPDAPYTTFRYPPCPRCLADPPIKAEGFRHTVRVDSDGAWMLPSSAGVLKPNVVMFGENIPNHVRSAAENAIDSAGRLLVLGTSLATYSAWRLAKRAKDRGMPIAIVNMGGVRGEDQFFADVNPDQAGELAVRVEVPTDDVLPALVSQLRQRLASGALPIDAPLGNHERENSSVFKDMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYR0</accession>
    <name>A0A2T4BYR0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1338090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYR0"/>
    <dbReference type="STRING" id="983965.A0A2T4BYR0"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="5">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="254"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="358" mass="39517" checksum="851CA3D5417E1430" modified="2018-07-18" version="1">MAVSREGARLARVLRQRLPAHQAAPLCARGFASTRPAHNATVKDDGIADIESTSSFTAPQPDQNIVKAFEEARSQDHKERRLPGNRYQYHPPKYNRGPLHPVQAPPSSDPTARDFVPGPFSFPRLKHTYDSTIAPDLMTLTYKHTPPGTTPPESQKGLLRQWDGSSPYHKNRPSRGPRGGGSSRLGIIERDITWNNIPEIEAVTINSYAPLAADNKEYLHVARAVVQAISGQFPEVTTVKHNVIHWGVRKGSKAGAKTTLRGGAAYDFVDKLVTLVLPKIKDWPGIKASSGDSAGNIAFGMQPAWMAYFPEIEFNYDMYPPKLMPGCDIFIHTSATSDRQGRLLMEALGFPFYGKVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYX2</accession>
    <name>A0A2T4BYX2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1440001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYX2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYX2"/>
    <dbReference type="OrthoDB" id="5281682at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="572" mass="64495" checksum="D690EEDBB292A12D" modified="2018-07-18" version="1">MQHDDTGDGSFSSPMTTSMVAAFLNTTSSPVSPGPSSPSFQMAKSTSFVPPARPSSTPFPHPETRSPQICCLDDSESSSDGNGWDQTSTEPVDAASGRPLARHFDELPTEVHEAILDHIFGYCVSATSRSTMRISSLTRGWSTALRHSRRRELTALALVNRVWRILVQQRLFRHIKLKATLDSIDNAMDFLVERPHLAEYIKHIEIWFPVFQPTYGPFALSNTLTLPTVTTDGLTNATYTLPGNNCTLDQVFLFVAAALPETRVLTLEGGERRKAPGVVHFDMSTGPPIEERRLEPLVSVRTLVTKGQWNLMRDDEDFKYLMRALPNLEEWQGSYSKPKSKTYITAAEFMPFLPKHVTNLNLCMESDYRREGVMPAFYYKVVQKAHLCSSLAFVLPSLEHFVYTGRICHHFFYDAARYAEHQTTNLRSVDITVKNCCRQSFSFHNSGSGIQDMAFIEAFEKLVLSAVRSLERFKKLDYLRIRFVDLDSVLPPLNPYFLVQDGKCTGVWSDVILTEMNRVRPDVTFPGLSDSFGNIVYSKDGRMIIAPEPSKTRITSLKLANYRSLATRITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ16</accession>
    <name>A0A2T4BZ16_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1028293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ16"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ16"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="352" mass="38747" checksum="570CA40B5EF1B540" modified="2018-07-18" version="1">MAFVRPTAEETIKHPAYPSVIWALEPHQRGVVEAAKGRGGPVKISWEIHGDGPTKLVLIMGLAGVKTSWQRQTKYFGHDHGSEYSVLILDNRGMGDSDKPLARYTTSAMAADVVDVLDHVGWTADREVHVVGISLGGMIAQEVACAIPQRLRSLTLVATTAQYEVGPAKSWGDALWARVGFVVPKSEEQGIADTSRQLFTDEWLAAPDDAATLPSPKTTPRCGPAPGTPDGEYLPFDTNFQRFQAQELYKKRQKGWFTRQGFLCQLVAAAGHWKTPAQLRSMADRVGRERIMIMHGTADNMITVANGEKLIKYVEPGVGLIVEGMGHAPLMDRPEWFNSVLEERFMAWAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZK3</accession>
    <name>A0A2T4BZK3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1403258</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZK3"/>
    <dbReference type="STRING" id="983965.A0A2T4BZK3"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="264"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB74753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="359" mass="39032" checksum="3BCF9638DE4E8DBF" modified="2018-07-18" version="1">MDSFVIKTPCSSANIGPGFDVIGLALSVYLELHVTIDRSKPSSEHPLNCRVTYEGQGEDSGDISLDPQTNLITRVALYVLRCHDQRSFPVETHVHIKNPIPLGRGLGSSGAAVVAGVMLGKEVGGLHHLDQDRLFDYCLMIERHPDNVGAALFGGFVGTYLMPLKPEDASRVEIPLSEVLPAPAGGVDTGKRPPEPPHGIGHHIKFPWNKEIKAVAIIPDFIVPTHDARAVLPPHYQRTDVVFNLQRIALLPVALGQSPPDPELINLAMQDRVHQPYRQTLIPGLCQIVESMSPKTHPGFLGVCLSGAGPTILALAVSNFEEIANEIIATLRKHNENKNLDCKWLVLEPAEGTHVVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZY9</accession>
    <name>A0A2T4BZY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">VAMP-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1440241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZY9"/>
    <dbReference type="STRING" id="983965.A0A2T4BZY9"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="9">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="278" mass="29910" checksum="53C54FD612F7052B" modified="2018-07-18" version="1">MSVEIEPLELSFRRPFTVEVAQILKIKNPSSSPLAFKVKTTAPKQYCVRPNAGRIEPGQDFDVTVLLQAMKSDPPLDAKCRDKFLVQSAPITADKEFASIASVLETTDKASISERKIRVNWLPAGDSPDHGPSAISTPSKPTTANGSYETPEPTRDYSSPTAADSSNAAPPPYVNEMNDDDDSRPQTAKSAASKTASAVASTVQTGVEEFKAKIAQLEAELANYKNSGLRQRNVKGGESEKNPVAALAQQPKQAVEGVPVKIVAILCLISFLLAYVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0N1</accession>
    <name>A0A2T4C0N1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1268185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0N1"/>
    <dbReference type="STRING" id="983965.A0A2T4C0N1"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF804">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="216"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="375" mass="43038" checksum="B5158E84C4F9F833" modified="2018-07-18" version="1">MATEAIPTTQLRLASPNGIVTRTVLKTPLRDALPSEIPIIDISPIFSQPLEERKAVAQQVRAAAQNMGFFYIKNHGIPADVTRDAYEACLAFFRQDKDTKMRADSRKAKWENGYRAPNTQRLNPYEGVDVRESFSYRYDPRYDDTVGEKGLDEIPEEARRYLRCEEYPWEKTRNLPRLRESLTRHIGECLRLARALTRCFALGLGLDEGCFDGKVRYPDASYGLNYYPPLERPTDEETDDATEGDREQQERVSIGSHTDFQLFTILWQDSQGGLEVLNKQGQWLRARPVEGTLVVNLGDLMQRITNDEYVSTVHRARNRSGRERVSIPFFWGFGLHETCGVVVGGEGERKYGDVRCEEWVARRIRDMKDLAVMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0N7</accession>
    <name>A0A2T4C0N7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_337676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0N7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="17924" checksum="D1F038B37AC41911" modified="2018-07-18" version="1">MRTTGITSYTIHPSTHYLASPAAQANIPSTSAKSSLWTTSSSSSKLHPPSPSQSYQRPYLDHKAKPIDRPRGLHARFSRSPRSTPRLAGDSASLLERFSRAHVSVERRDRAAAAAREFVAALLVASALPHSASVCDGYKVVSTSPGGQPLLRRRSEESSLVFRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C131</accession>
    <name>A0A2T4C131_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1423334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C131"/>
    <dbReference type="STRING" id="983965.A0A2T4C131"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="271" mass="28894" checksum="1B2616C7A6472D7C" modified="2018-07-18" version="1">MSHSHEGVSHSHDGFSAQEHGHSHEILDGPGSYIGREMPIVEGRNWADRAFTIGIGGPVGSGKTALMLALCLALRDKFSLAAVTNDIFTREDAEFLTRHAALPPQRIRAIETGGCPHAAVREDISANLAALEDLHAEFDTDLLLIESGGDNLAANYSRELADFIIYVIDVSGGDKVPRKGGPGITQSDLLVVNKTDLAEAVGADLGVMERDARKMREGGPTVFAQVKKGVGVEHIVNLILSSWKASGAEEERRSRGGPRATEGIEGLKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1J7</accession>
    <name>A0A2T4C1J7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1379605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1J7"/>
    <dbReference type="STRING" id="983965.A0A2T4C1J7"/>
    <dbReference type="OrthoDB" id="5030973at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="311" mass="34572" checksum="DD00280B6A32923E" modified="2018-07-18" version="1">MDWGEIWLSDDDGGNLEEEDEYPGHPTSFTLGLTYRGQEGDFHVRNLPGQLQRQRVSVRHGGLGKRHAFTAVCNAKAIVHGEMGPPSDKHATLLVFEFKFNSYRGTRIKEADVLFEFQAAQGQAGGPSVLQVRPRGRHQMQQTSQQESPRDAQELSLGVNVVAVDASLKLSRGASADKDTQHFTVVTGDNPQSLRYGDYRQARFALAENRSQASGIPSRFLACVLLERDTDDDFVCVPHVEVKPDFKTMVASLFSSQERDDPILFKVTEPPVIKLDSLVEIDRLNLGAVDLNKLWDCTAYNLYGHAIKESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1L7</accession>
    <name>A0A2T4C1L7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1274780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1L7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8566" checksum="386952082AB00C90" modified="2018-07-18" version="1">MDQPINLPSLFMSLRCRCVEIQNSSRGPEKSSETSKVLYPAGISLLSPPLQYCSPMIFSIRPMQNKRANANQSHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1U8</accession>
    <name>A0A2T4C1U8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1402077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1U8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="87" mass="9672" checksum="ED3068E21336AB19" modified="2018-07-18" version="1">MDLLCLPDCFACFAVCFAAFYPIRIFFLFSVLTKRLRNARGNGPAHFSRSSGIIAGAMMPPTTRHIIEATNTYCLEQADKILQTPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Y3</accession>
    <name>A0A2T4C1Y3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1439297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Y3"/>
    <dbReference type="OrthoDB" id="3926209at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="246" mass="27600" checksum="3C3C99DC6EC80828" modified="2018-07-18" version="1">MEAAEDVDAEADPVEERKTFASSLMSPVVTLMVGKEEPTLLQAHQAFLVRSPYFEDICSKFAEDGSPRHIELPDEDLDAVGCFLEFLYTGEYFPRKIAGQRTLEHDPSIPPIDDSGIQLLKHAKIYTLAQKWGVAALQTLAANKIHCINSTVKGEIEYARYVYANTAPDDTTIRAPVANFWATRSHTLRSEAEDEFKALCLEFPQFGFDILTRVLDDKLKRERNEKMHPSSGSVRKRPRHSSATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C274</accession>
    <name>A0A2T4C274_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1439330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C274"/>
    <dbReference type="STRING" id="983965.A0A2T4C274"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="131" mass="14174" checksum="B0E399829ECBF5F6" modified="2018-07-18" version="1">MIQLKTMLNCIDNSGAALVECALVVGQKRHARIGDRIVVVVQEQRGSSSSGMAGMSAAAKVKRGDIRHAVVVRTRYPTQRRDGTVVRFDDNACVLLNKSGDPVGTRINGVVGAELKRKKWSKILSMAPMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C296</accession>
    <name>A0A2T4C296_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1334551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C296"/>
    <dbReference type="STRING" id="983965.A0A2T4C296"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="244" mass="27453" checksum="8533DDB4B76D359E" modified="2018-07-18" version="1" fragment="single">MRLLHTKELETGGFELQEFGEQDTPPYAILSHTWGDGEVTLQDMALGRFAGKKGYEKIRGCCSLARANGYDYAWVDTCCIDKTSSAELSEAINSMYRWYGEAGVCYGYLADVPSTAEFAESRWFTRGWTLQELIAPETVIFLDEAWNELGTRETLKQDISRRTGIPLSVLSGSDLNGMSVAQKMSWAASRKTSRSEDRAYCLMGIFGINMPLLYGEGERAFMRLQEEIMKVTDDDSIFAWRSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2E0</accession>
    <name>A0A2T4C2E0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1392254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2E0"/>
    <dbReference type="STRING" id="983965.A0A2T4C2E0"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
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        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
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            <begin position="182"/>
            <end position="215"/>
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    </feature>
    <feature type="domain" description="J" evidence="2">
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            <begin position="270"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="41629" checksum="0F11C3A82F44A21F" modified="2018-07-18" version="1">MATFSRIVPPPSAKDMAPTREMLHHIKSAKDTLQRGSAMSMVLHALDQAERGLGPGVSKPRKWQLMRGEAYLKMGRENSLGEAQGIAMSLLRQNNQDPEALVLRGRVLYGQGENEKAIQYFRMACSCDPDFRDAVKWLRIVQKLDRMKEEGNTEFKAGRWQAAIQKYSDALDIDPSNKSMNAKLLQNRAQCKIKLHQYEEAIADSDRAVSLDPSYTKARKTKANALGKTGNWEECVREWKAIQELDPTDNSVRQEIRRAELEMKKSLRKDYYKIMGLDKNADANDIKKAYRKMAVKLHPDKNPGDAEAEAKFKDMQEAYETLSDPQKRARYDNGDDLIDPADMFSSGGMGGGMGGIDPEILFSMMGNQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2G9</accession>
    <name>A0A2T4C2G9_TRILO</name>
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        <recommendedName>
            <fullName evidence="3">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_66462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2G9"/>
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    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5672" evidence="3">
        <location>
            <begin position="135"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="357" mass="41079" checksum="7FDC3ABA26B13B15" modified="2018-07-18" version="1">MSGFNTSVVLTVAPARILVPILLVSVWYLGRLHSQYEPIVSSRVTSRLEEARRMIPSVKLDWPIPPTKDPRPAFNSSKLALLIEARPLPHLPPLMMHMMAVVPPDWRFLFIGSSESILSVSRAYSIQHQQVIGKLDMVELPPPWSIASKEDVFRLLTDPRFYDEFLPDVEWILKYEHDSMLCANSETSLNDWLDWDWTGAARPDDNGFSGYGGLSLRRVSVIKRVLSFQARFNDSEPEDDWFGKRLWILPGAKIASKLEGAISVEDVYMERPVGFHIREGGNNVNEDMWSDAARRREIFEYCPEVSMIMDMKLERERCPDDDGSGKREDQEPREKPVEAELLWLRIIEAMDLLPWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2V1</accession>
    <name>A0A2T4C2V1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1378624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2V1"/>
    <dbReference type="STRING" id="983965.A0A2T4C2V1"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="384"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="388"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="676"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB75901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="769" mass="86370" checksum="9416D716D48EF602" modified="2018-07-18" version="1">MFRSIKRKTEAAFRRRKTNRTISSTVTQVTAPTDVDWPFQNDYSSYPPSTTHSAAAATTNNVTPGAGSEQSSPVEPRRQTSFEGGGDTSVAESSSLDLSYLEEPYLEEGVDAAGIEGAEDEVREDAYTTKYVPFVETSAMRNNMFVHAATSHYGMVNPAIMSGFGDDDESIWLVDDEETEENSAVERQGHEMREDEEEDELVQEEREEMGEEEPDIAPPPTNQSPVVPSVSEAASTAGPQTGFTYRINYALFDDDEFASSQEEEATATSVSVGRAPSLRPRSSGTNSLESLSVGNGSHRPHETRDTIGASSGSSTPATSNPYVHLLEQQDSAMMVAYQRRLDLSGRRGDDEADDFSFGQRYQKDPDTLAVLVTHQRVPSDHAAGDRDCSICADTKEPILFPRFSPTASCEHPPTACLECLEQSIRSDLTSKIWTDIRCPECRGLLDYTDIQRYADEETFKRYETLALRAAMAEAENFFWCTSDCGSGQIHESGHELPIVICLHCSHRSCFRHNVAWHQGLTCDEYDQLLANPDNFRSRLEIDNDAWAASQQAQLNADRAMAQGLLEEERRAAEMRHRREREERERTRKAIELARQIAARRKKEEEMSRITVGRTTKPCPGCGWAIEKNDGCSHMTCVKCQHQFCYECGADHRQILENDNTVHLDTCRFHPSQLEESGAEETEDTYEEEEEDLEEEERSVSDEDDEFGSYENYLDEEEDEEEGEHTEDEGEEDDDDYDGYVDYGSEEDGFDGYWIGSDEEVRISESTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C315</accession>
    <name>A0A2T4C315_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1265351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C315"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="6">
        <location>
            <begin position="1663"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2001"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2508"/>
            <end position="2648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2768"/>
            <end position="2985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1832"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2006"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2595"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2620"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2630"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2791"/>
            <end position="2823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2824"/>
            <end position="2843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2885"/>
            <end position="2897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2908"/>
            <end position="2919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2920"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2943"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2974"/>
            <end position="2985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2985" mass="336475" checksum="BC44E59EB2D0ECF8" modified="2018-07-18" version="1">MALLSPTFLIGVIVLLYIFSFVLFAVLRIVTGVSIQRIGYFSLRRIAYTPRDGIRIEVRGLGLNIHRPTFAQPTWLSIVLSDLTVTADFKKLDERKPAAKNPPRDANRKTASADDDEVDPLLEVPPPAQASSGSEAETWARLHKLKEKVKKLHHGVKWLRMVDVVVTNSVINVVDVGSLQVGSLTLAVDTRHKMADRARFFFHRSDSTKENAEAEWILTVRSVFFAVDGNESLQILDHALLNVHGFLYPTQEGLREATVALKLGRVQIPYDELHHCATKFKLSRKKPKAANVQDPVDVFVSKVKEASLGDASEHLMKTVSDSKQFFSSILRGIKEVQFAVSFVGLVKKVESVNPAAKPVHLTASMKEVGVDLHRLDPKSPAHRMYFPSTDIAHEALVAALSISVGMDDGHGKPERIVYIPMATTTIRTTLPSKTIQLSRVDSFEEKNANILFANSVVTSPSIDLDPRHLPLLIAMMRSRPKPSKTEQKQQRKDLFSRLLPKASIKFTMHEPVLRIKLNPLGETENPDDYGLIISSISSVSLDAESSHSPLDDLHYSLDGAMRLQSHHLYYQAVSGERFDLITTESFDLKVHLAANPEVSVDATSNVQSFSVSMVRPEITDGIRQIVRQLRTDVEPTKRATPKSRRHPNFLRSLPEWLFRYQVTANDVNIEIAGVDEEISDDSKGMSLHIDGLSAEYRAQRLDGLQRRMLRRRTHSRSLTQSDSDFASSSPTRAKKPPQTIGDGRRLVFNAKGIEAQIIETADQLELEPFVNVPRLEFSLSASSDNHGPMFHVQSSIRSIMVQYSLYRHYAVGVAMKTLRKAFMKTTGDAPRASQQGLSQPDLLVPPTGGFSSADASSAIADSLVVDVKVALVQIKAEMPHDPMVMLHIYSLDAGRQRWSTPYFTSKLIRFYVASPRMRNIWSRMVSIKSGRLDLRESKHKSPQGAYTEEKLIDVSAEAIRIGIPHEVIVHRITDNIINVIKAVQQLQHRFKTGTNEYILEKKPEGAKTVPRVSVRSRNFLFEMEDGAFEWKLGMIYRAGRMEQMQRLTRDEAFRLKLKRVREEELKRGNNGKTRSRSAFSRGRTDNSSSAWFRSRSSDATKQDERGRERRHSTLPRYDPENETLGISGNAKVSAEEARLHLDMFNAQAWKKRIDRAYQVSRDGVKELRGLFWGQNEVPSDIEETENILEVPARPALMATYISNLHIAVDKPTFPLQDLPDFIHKVGKGMPKDMQYSLLVPMHISVEMGEARCSLRDYPLPLLHIPGLKTGQSSRLQAVSLRTNFVLAEEFRGLDSSRRVPVNIIPPKSTDPSASKEGCFAIEVRRTLGPVKSFSDVYMDINTALPTRITWGPCYQPAIQDMMMVVESFTKPQIDPSERVGFWDKLRLSFHSRIHVAWKGDGDMHFAMKGTRDPYQVTGHGAGFLMCWRNDIRWNINAEDNPKKFMTVDSGEYVLAIPDYSSQVREAARLRDDDSSRLANDHMRCGPAQFKKVVMKLSGRVQWLAGLIFERAIEDGKRSFDFKPHYEVVLKNPLFAEPDENGLPYDAMRGFRSRHIHLSIAVRAPADREWMSQNLEPSRSYNTIHLTPRFFTHFFAWWGLFSGPMSLPIRQGSLFPGREKNSKKFGRHLATVKYNLLFAPLFLSHIYKHKDAEDYSENAVSATGLKVRFDSFMLDLHQRREEFNTIAKTKNSPSRITGIKLHEAHLDLACADLRAVSASLYGTTTEAIRKGSISHLTLDQDDKPDVSRFTIPDGDYSWIDMDDFVELDWILPTEAHPETKILPLAYVPRLTYFRQTDIGGIIAGDPTRTSPFGDEPTHFCIMSEENDPKSVQAQLIKERLEQLDEQIRAHIRHVGEAELKVIRTDSKDQEMLEDFDILRQHSNVLRDKRAFLETTLERMKAGVPTNGQPFNGAASIHRSDTASVDAPSEHMDMPSIPSNAEFESEYENRFVIHNMQLKWNNLLRNIVLRYVHQSSQRRGFIYYLSRPAVKFILDMVDEQTKARNERTTTSSEPASSAANGTPTSPDAPPLERDAAKDLEDRIKGMMGDGRKRCSTGFAINSNGVVEGSLEDLESGISDEYNPQCSYHVRLIAPQIQLQSEKNKKHVVLVTSKGMELKVVEVMDKSRIADNVSGLVQRRFLVNMDSTQFFVTHQKWFTTNLVSMYAGSKYGTPTGTSWPPWVPMEVMFDFRTDPFGFKRVVQKTSAMLRYDKYNTLRLKSNDEVNADDSDEATQEPTERRVDNLWVEFPQARALCNSSQYYAMYVIVLDLLMYSEPLEKTRNERLEKIILGSDFSDLSGIPEMVMKLQERIRQMEEIKSHFQTFSLFLDKKGWEDRLALERDLAASEDELFFMMKAIMSSQRRFEKNTQSNALLKWSISVRDIVWHLMQVSNEPLVELQLKDLEYDRTDNADGSHMNLVRVGKLLGLNLLPDATYPEIIAPYHDGERPGTRYGDGDDSDMIRVYWYMLEAIAGIPVMEKFEIELYPIKIQLEREVGKRLFEYIFPGMDMDQADEEGSESPKSTISRHGTPGPESPSFSTRPGSLELRLKPTLSSSVVEERPSSKRTLGVNNAEGGGGGHFRLFRSGTTRTLAKKTSVESLRPQTATPRPGAIGRTSTGISSRESRDSDSTKKASRFGLRSRHNTEDKQMSDDLTKMIERANNYITFAHIKIPSVVLCLSYKGKDQRNFEDVHNFVFRLPTIEWQNKTWSNLDLALALKKAVVRALISHTGAIIGNKFSKHKPNAEQRNRLRELASSSALISPMASSLSQNYAPSIHDSDDSASMYGTSPIDYSRSPPRSTRSSIRSGIPAPRSASRSSSIASSRSHLTGGSTQNLPQVPSYLTMTPPTPVDAVGRGEGHSNLAIDLLRPSSSQGLGSHRSGLMRTLSGGSDSRPSTSSGPLEAADRKKNGTTNGSSTSSFGFRDKLSALTQRMRDRDTPTVVQTDEPEPMNDEEAAASPTTAVDMNEERPARTKRMSWSQTRSKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C368</accession>
    <name>A0A2T4C368_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_311999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C368"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="19597" checksum="0E8D018DA391552E" modified="2018-07-18" version="1">MALLVVRCPSMYVNGHDHAYAEDFFAASDQHRLESSRHAQFSISLTGARVSRWKPNALTTPFFPLSLPPIGGHHPRASSILDLLDRLRDAYKQVSTQGLTQNHPASLHMYSHTFGVRSCCAIGPIVGPDWIRLGSCQPLLSRRSRRAQCYLYALASADSPSPRVNVRLIDCLSACPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3U6</accession>
    <name>A0A2T4C3U6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1333501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3U6"/>
    <dbReference type="STRING" id="983965.A0A2T4C3U6"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF103">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="364" mass="38526" checksum="FC966875CA877921" modified="2018-07-18" version="1">MAFSTRSVLRASRAANFSAASRAAAPSNAVRFFSATRGVRVSDTANKKSVVREKEVPVTNYGAGQGDKSTLQVPEGAAKVPYDSPAPAERDEVEPLSKKVYDQLPHTLKTMTVHGKVIIITGGARGLGNHMARACAEAGAKAIVIFDANQELGDASAAELHQKSGLPVSFFKVDVRDGAAINAAVDSVVELYGAPDVLVNAAGIADSNIKAETYDPAMFRRLIDINLTGSFLMAQSVGRAMMAAGKPGSIIMVASMSGTIVNYPQEQSCYNASKAGVIQFAKSIAAEWAKYKIRVNCISPGYMDTALNRVPALEAQKKIWKSLTPQERLGAVDELNGLCVFLASDSSSFMTGSNVLIDGGYSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4T9</accession>
    <name>A0A2T4C4T9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4T9"/>
    <dbReference type="OrthoDB" id="4898523at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="383" mass="42655" checksum="C6458833ED4A0E0C" modified="2018-07-18" version="1">MAHSRDGRWNKPTSTAYEAQTTPTMSARHPSDDVISISSSSGCDSDCRIVKVLPSPVKRGKNRSTRWKRKPSNIQTKREATLTDQRGREMRIRQREQAYDRDRLGTRSASRVHAKWLNEDSMQRRRDAVCDGGLQGTKRMILKDGHLSVTGEDSQAGHQNTVDSKLSSASSPFSSQGVECKLEVRHQGDDDNWAVRSRSCSTATLDFSPRIRAAQLEGHKELRRDGQELLSMLNGPSEVLDFGPTPRSSILEHGEGEVASSSSAYPMPSAGSTSILKEESNADGARLTRKRRSRHKSRANDDQSGSTGGPQHRIGAWVAAQRDRHQLPPIRSGPMWESIINVGAFSALPGPFFTRPKRVLREVTYEGAMKERAKRKRKRGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4U8</accession>
    <name>A0A2T4C4U8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1229898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4U8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4U8"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="21996" checksum="4C228DD0842B66CA" modified="2018-07-18" version="1">MVNLRTQKRLAASVIGCGKRKIWLDPSEQNEISNANSRQTIRKLVADGLIIRKPVTMHSRSRARELNLARREGRHRGFGKRKGTADARMPSQVLWMRRLRVLRRLLVKYRASGKIDKHLYHELYHLSKGNTFKHKRALVEHIHRAKAEKQREKALKDEMDAKRAKTKAARVRKLERVAAKRNALMVGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C531</accession>
    <name>A0A2T4C531_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1332289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C531"/>
    <dbReference type="STRING" id="983965.A0A2T4C531"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="301" mass="33344" checksum="58953036E75326F5" modified="2018-07-18" version="1">MAPHNDIEAFHEVLRSSRRILALCGAGLSASSGLPTFRGAGGFWRNYDATQLATVRAFKMDPGMVWLFYAYRRHLALKAKPNNGHRALAALARRNPDFLCLTQNVDNLAQRAEHPPSQLKCLHGSLFDIKCSNESCDWMQKGNFDDPFCAALAPASVDMPNGEPLPLLDPYHRVKHITEDELPKCPQCTSGLQRPGVVWFGEDLDAYMMMDISAWLRAEPVDLMFVIGTSAGVYPAAGYIDKARRLGARIVVINLEAEDEAEMLKMKPDDFAFGKDAAEILPVLLEPIIGKPNEDGEFQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C562</accession>
    <name>A0A2T4C562_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1391260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C562"/>
    <dbReference type="STRING" id="983965.A0A2T4C562"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF288">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="155"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="418" mass="48336" checksum="0740FCAEA23432E5" modified="2018-07-18" version="1">MDVLKQILIIILAICFVVFITFFGRLPALKNTPIAWLHKLLWIYIPNVVLRIDQTLTAGRVTGSLAWLYRRLMYDRHPTIVIFFLLIMTVSEYMYLPAVLPKISPLAQSTALITVLMPYVFLYLACSADPGYITRENHAHHMSLYPYDYALFHPGNECRTCRFLKPPRSKHCDVCKRCIARADHHCVFINSCVGYGNHHWFLLLLLSTCVLVTYGGLLGLYLLTAKIREDYPTFTLWPARDMDFQRYLAIWGWGLHGDIRMGASTLLALLTAPLIWALFLYTLFLIYCGTTTNESMKWTDYKEDMRDGYAFWRPLAPDRPRNRRLEPPCPRWPSSPEHIILTTQDAQPPSQERNFAGQGEWERVWDLDDVDNIYDMGFLHNLGDIFFSNYTFGDGTGEPLTERRPRGRSISAKSGYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5F0</accession>
    <name>A0A2T4C5F0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1332322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5F0"/>
    <dbReference type="STRING" id="983965.A0A2T4C5F0"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="336" mass="36676" checksum="5F1375BB7EB57423" modified="2018-07-18" version="1">MHAKAGPPPPSTPQEFGHGAPSGYTFQYSNCTGKRKALLIGINYFGTKAELKGCINDVHNVSAFLVERYGYKREDMVILTDDQTDPVMRPTKANIIRAFGWLVNGAQPNDSLFLHYSGHGGQVEDKDGDEDDGYDEVIYPVDFETAGFIIDDEIHFHVVKPLQQGVRLTAIFDSCHSATVMDLPYVYSTKGILKEPNLAKEAGQGLLGAITSYASGNMAGVASSIMGFAKQALNGDGAYKKTMATRTSPADVIMFSGSKDDQTSADATIGTQATGAMSWAFISALKKNPKQSYVELLNSIREILETKYTQKPQLSCSHPLGMFMTRLWRSCRANMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5K3</accession>
    <name>A0A2T4C5K3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_19173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5K3"/>
    <dbReference type="STRING" id="983965.A0A2T4C5K3"/>
    <dbReference type="OrthoDB" id="4897642at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1208" mass="133595" checksum="D1D9CE6D4501E240" modified="2018-07-18" version="1">MERQSKRRREGSQEPASSDSDLMHAGCQFENIDIDRDDSSNELADATLPNLSHPEDNDSCGGINDEPEADEIPGPGSSTVSSAPSKDWKSTLDVVDRDFTVAKRSDPWFPIPRWSRTTSTYAKQVAFKFAMAIRMLDALLASPAKVSEGKPAPTEQTDSAYASMPGDASTTCPANWTRHSQEVQPDFEAFHTRDAENTTESPTLCSDQSSVDANRSQDYVWEFTRHLYQRIRPFLSDDNVSSAVALLPDLLSAFALQKGQESQAQVNQDIRYFVYKHRLLLAQSLAAFYETEQASTSQSLSDTGFMVPERISLIWNRASHKGSSSGPEESSHPCLDADSDGNSSGGFSQYREAITTGPAFHWVVEELKRELSPSPSGLYTMEKMSSDILKGLSKDQKMRKRHPSNPSKLTFNVACDIFAYMEDQGYAMDADEVLPRAITLTGSSTNAQALTIRQYVCQTWPTIDCHLVEAIQAALRVYKASGYDASKPFQNSPRCVVDDVGTEVRVSIGEKMMNVEAVGKVCSIAAIGAQLGWLATTLSSSHRERVISFCHPEISGLSAHLNEDGFDNTFSCRVNTETEHLRDNLPSVNGQCWLRLFNNPVVVTGYPIKSRQDFVVEAGLELPFDMLATLSECQFLTTWEGKTVIKGFSTMLIPTRVQDNIISWHLIVSEAGKRLSYRDDQVSKGISIAPQILPDARHILGWCAEAQDNIGAAGANYKIGWSGLPLAGNDVSLGPVTTSFGLGGFVKVSSNFTRGNRERITSSYTGDHSSSPGDYTRSLVRHIGQQHFLLWDVDEKRGWLTDGSRAHLHLVRASLWEDHREKPNGYYIDRIKRLNELALLKDNAAEVLLDAENLDTEAEPRDPAYSSLKTRMQEIGCLMEKAIDQVRKATNSQGTSVGMSVHVLEGFDFMDVATLRDLHLHTLKLPFLESGDGWASLVPHLPVVTLFGKGFGDLIRPGANNPTKSCDKCGFVVSLPSGRHLLAVCVDVLEKILRIRGNKDSRPWQLIHELYWPAREPVFEPCTCTGSEGRGNSDGRVQMLSKKKPRGASFSKPIKLEKRGAVIFGHSFRLSLRTSRLFHSHDRASFSSNTSSATQTTKQVADVPASATNDESFDTNENPLSDTISSITPNTATWSRTEDLISNDTTIEQQNQAPATVCAKTDTFAASPPTIELRVSAEPPRKRPAKRVREFCATAWKKVKMIKPRRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5V7</accession>
    <name>A0A2T4C5V7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPCR, GprK-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1438641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5V7"/>
    <dbReference type="STRING" id="983965.A0A2T4C5V7"/>
    <dbReference type="OrthoDB" id="5313079at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="539" mass="61082" checksum="452A3AA4A9384179" modified="2018-07-18" version="1">MGTEFGINKNTKPELRLGAVAIFYFVFAALWTTILLAGMIFLWVRREMPILRIRGLALSFAAISFMHTYWLAVQLAYWYGALMPEVAEFWIMGVWFPFGIALFHASNSRFLYVADGQRKFLQRSEVPSAPVGQGGLLARWRKLDYNRRSLILIFACMGLQLAVTAIIFLVSRKFHSSFGIAGTEVHGSFMEQKVAQGRGWEWVPSILWQMFWAWIFAPYILFRARKLRDTQGWRFQTIACCISNLHAAPMWLIALYVPAMEPVNTYFIPPQWVAASVMLLEIFTVFVPIIEVWKHKALTQETLDSIARWESQKKGFNGGNKSLNSDSTRSSWGGRHGRSSSVHTSTSGGSILTMEALEHTLSKNPEPLQQFSALRDFSGENIAFLTSVKEWKATYFPTTARESEKEDGAVKVLPRECFESALRIYVEFISATHAEFQINLSSTDFKALQSIFEQAASVISGRERGSPDPCTPFADIPDRNGSESTLDVRYGGDVPADFDEHVFDDAEMSIKYLVLTNTWPKFIKERRSFDMASMEAGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C688</accession>
    <name>A0A2T4C688_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1355392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C688"/>
    <dbReference type="STRING" id="983965.A0A2T4C688"/>
    <dbReference type="OrthoDB" id="4893733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="153"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="642" mass="73059" checksum="A062682BBB45C109" modified="2018-07-18" version="1" fragment="single">MVRSSERTGPADPVRKSRAIDREHGRVGARQHATSQGQGLRPSRHQTSIIRDRPAINWGSGLQCNNHGGTQNVVTGGTLIAGSTFNGEVQFIGEERESRAEILHKLRVWLLGDHTPEERYETSIRKRLNSTCDWMLERPEFTDWLSAAPLLPKLLWINGPPGFGKTVLCARLIQYLKTKHQEPVGYFFSSDLESHKDPVAAMRSWIYHITQAEDSVLDAVHRKWGHGLSASQDVVIELFREAMKSVSNCTLVVDGLDECSPGENRLSLNEFIGELNEAVNGTTTRVLITSRNEPRIHRAILKAKHTTLFQYEVCENDVRSDIDTLSRHIVSEKLSDREESFQIVMIKRMSDQSKGQFLWLRLQEDSLSGGLNQAQLEEAIDRTPADLSCLYGRNWERIQKLPADKRARAMSLLRLAAFSFRPLTVREISEAVLVSDEYKDFPVRELPDKWDENYVQHRILDLGNSLLETRMQNQDAPVGEWAIHLIHFTVKEFLLARIPSQDTVRGNDKLMLAAVHTSLAKLCVTYMKYPQVWQGSDGDNSSRLGSFTDYAARFWHRHTEAGAAEQRRLVDIEDFFHVKNPSWAPWRKWFDSTHDGWGNAQSRAAPPLCYAIELGFVDLATRMIKKGRMRIKCNANNRTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6C5</accession>
    <name>A0A2T4C6C5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1422134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6C5"/>
    <dbReference type="STRING" id="983965.A0A2T4C6C5"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="20"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="481" mass="52153" checksum="6FA382EE1DF7457B" modified="2018-07-18" version="1">MEPAIEMAAPRKSFFQTALPVFACGAGLFSDGYVNNVIGSVNTILKLQYGTVYTSSNASKYVSDIAFAGTVVGQLLFGFLADRWSRNNSLLVSTAILVVFTALAAGSYYHGDAVGMFNMLTAWRFFVGIGIGGEYPAGSVGCAETSGELKSGTRNRWFILFTNTMIDWGFVIGAFVPYVVAAATHNGHLSTIWRTSLGIGVVFPMVLFILRLKLKEPEEFSKNSMRHKTPYLLVLRYYGFRLLAVSVIWFLYDFSTYAFGIYSSSILAGIYSDSAPLTTIFGWNTVINLFYIPGTMIGAFVSDIIGPKYTLIIGVSLQAIIGYIMAGVYAKISHHIAAFAVVYGIFLSLGELGPGNNIGLLAAKTCATGVRGRYYGIAAAIGKIGAFVGTWVFPYIEKAGGDDPTKAAQYPFWVASSLCLLSAAIAFFCLPNVGQDTIAEEDAKFRVFLESHGWDTNQLGMGKSDSIPTYHEEELTMPKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6I1</accession>
    <name>A0A2T4C6I1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1401464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6I1"/>
    <dbReference type="STRING" id="983965.A0A2T4C6I1"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="376" mass="42443" checksum="5AA4EC0B95933E57" modified="2018-07-18" version="1">MTATAITVPDGPDTKNGYTFLFVNIPLLVVAICIVGFRVWWRCIKNGGRTFNKADVCVLICLIFNIIQVSCISVAIVKWGFGHHAAFLTAEQRYYSLLYFFIFQCFVKNTVAITKLSFLFLYLDIFPQKKFRMICWAMILQIAAGLVALSFTTIFQCTPVQYSWDKTIPGTCINIKAFWYGQSGWNTLMDLLVLVLPIPVILKLQMNRRAKISILAVFILGAFVTITSIERLISLNFNATFILDFTWATGTSVIWTQVESTVGVICACAPSLRLPLARFIPFLFGSTKHDQSYELNDGVHGREAPSNKWNSQSTRSKRRGDFEVTTNDLETSYRSDGSEEQIMGIKKTVSIDMTFQERAPELDADSNKLGLNQQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6K6</accession>
    <name>A0A2T4C6K6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1420995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6K6"/>
    <dbReference type="STRING" id="983965.A0A2T4C6K6"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1280" mass="143625" checksum="33E8DE4AE0A3CF73" modified="2018-07-18" version="1">MSTNSNGDARNGGDADVLAKIHLALEVVHSPHSTNDARREAQSFLEEVKDIPEAPFQGYNLAADKAQPPVVRHYALSLLEHAIRYRWTTYTEEQARTLRNWVLELSQAVAKDDPGYLRNKTAQLWVEVAKRSWGSEWTDMDAMLVELWQIPNSPAHKELVMFVLEALSDEVFAGDDPVVAMREGVLSKACVEIFTPTAVLVEAFPNRQAGPDVRCGHEGWLSRLSDFLGLCISSDAKNDEVKTCIVKGFSVLVSLMPWAIPKAVSSARCVPILSAGLASQSTEIQKAALDALYALYCRSNFTDEEFRELVAPMYSGASIQLFRDVMDRSAVDADDIDEDKYQILKKLSEMLSILGDYFERKHSQVPMDANPEAFLQLLLQVVQHQSLMVSIPVLVTWARLLSNKVIGPSDIVTSMIGPLLEVCSSRLVRYENLDPENTDPTFLFLMEDTDTIPERHAFLGNYRRFSSQIVELIVQLKLVDAVSHILGRTEQLLLHLYDGQPPFSKQNYFKHSMPVLQVDAHFTLIEASLKGYAKWKKLHQHDNPQQIAELESSLEEWCSRLLEMNFEDPLIRKRTLQLLVFFSTNALNKNANFMLKVLEHIILTWPVLEAEYRAYNEAVKDFQTESMLELHRLAIGMPDHLLGVYDQIEVRVNEMISTGKLDDRRILAYRSFLFLIIHRAKSIDTQAKVPKLREFVEPVKAQWQEEGIKSAVKSYSGFCELLALDKAQAYLVSRRAQNIQDWGSYELDAEGLALQNELEERLKQLPLRPTKTLLALSVDRVDKSTTAFQATCAIWEEGFPNILADLLRLLSYAHASHNPHHWTGFPEDMRHIVDKVLSDRFWQAGISEGSKDDFYARVFDKKGTMEGLASTIRGTVRFVRETAYGIIYCMSKLHSQFYGFSELAAPLSEAFFSDSIWLSTHQQSNLLSLVRHLVDDCPVDCRENFLPRLLSSCFQQMDAKINSEWAKLEQKQSVAADGDAELKEEMKSESILRQVTYTAVVMVADILDPTKPNSPTLKSQAQKADEHDESGEAYPSLRKFCLAHQEIIEPLLLFCMHGIRMRDIRCCGMVLRLFISLVPEFSSSPSHGSKRSLTSPDAQGAGGSVDAARISPELASAAREYISSDVMRACVTSFHEPYFVDVQKELASLIATIVVYYSPITSTPVNVLLALPNVNPAELERLNAYVPKPASHTRQQRAIVMEFLKDFKGVSVSEMGKLSKTGVDSGSSRSKRTGRSKMAQGFMTSAPAASDAAGRKRAEAGGRATPDNDGLEGISNLFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6X2</accession>
    <name>A0A2T4C6X2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF602-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1400228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6X2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6X2"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="266" mass="29064" checksum="9467DA2F8C23D613" modified="2018-07-18" version="1">MGNDGGSIPKRRELVKNAARAPTISEMKATALESLAHAWAHCALSDTPLDFESVVSDWRGRLYNYEAILNGLVPSDDPNEVTPAALGIRSLRDVAKLKFSKTGDKWACPISMKEMGPATKAVYLVPCGHVFAEVAITEIKEKACPECGEAFTQENVIAILPTAEKELDRLQKRIEDLQANGLTHTLKKGKSEKKKKRKAGEAAEEEEGSAEKNGERAKKSDASRAKKEPDARIKGINNSMAATLTARVLAEQDERNKRRKLAQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C784</accession>
    <name>A0A2T4C784_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_279522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C784"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="17540" checksum="0AF3437E0A40A2D9" modified="2018-07-18" version="1">MIWALGRLLAGDPVPCIGNQPGYKDGGVSCTRRRVSDGERWHSNREKKTLFLSLCLAEVDLNEVRPRTLFTRLERLIRDHQAPRVVIPYKAVVLVDRVQSTKRPGIRPFLVLAEEAVWGLSPRAAARLTARSPVPNIIHLPRRDVLALRPAHLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7K9</accession>
    <name>A0A2T4C7K9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1374863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7K9"/>
    <dbReference type="STRING" id="983965.A0A2T4C7K9"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="301" mass="32444" checksum="2EBDA9D3C093AC78" modified="2018-07-18" version="1">MRSTSSLLFRASRALQHENPLGLPRSGTPPSWPKRPQRRKITGVDKVIAVSSAKGGVGKSTVAANLSLAFARLGFRAGILDTDIFGPSIPTLFDLSGEPRLSSNNQLIPLTNYGVKTMSMGYLVGESAPVVWRGPMVMKAIQQLLHEVDWGGLDILVLDLPPGTGDTQLTITQQVILDGSVIVTTPHTLATKDAVKGINMFKTVGVDILGLVQNMSLFNCPNCHHGTHVFGSNKRVEKLCQEHEIDFLGDIPLDPNIGDDGERGKPTVVSEPSSERASAFLHIAKAICPKIDLKEVEGRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C861</accession>
    <name>A0A2T4C861_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1400714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C861"/>
    <dbReference type="STRING" id="983965.A0A2T4C861"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="67"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="349"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="437" mass="47260" checksum="D3CCE6F3163C63D4" modified="2018-07-18" version="1">MPIALSPPFRPRPGLTKFTNCRLLRGDKLVHEDLWVSSVSGKVVNSQAAFFDDLVLPDQTIDLGGRIVSPGFIDVQLNGAFGFNFSTLLDDMSQYGKKVKEVQKLLVQTGVTSYNPTITSQRPELYQKALPFLGPSGHLQEAEDGAESLGAHCEGPFLSPTKNGVHNVDVLIEAQTFEDLEACYGKHNLTPRAEGERIPIKYITAAPERGQMMKLIPELTTRGITYSVGHSEATYEQASEAVGQGATMITHLFNAMRPLHHRNPGIFGVLGIAESLPRPYFGIIADGIHLHPTTIKIAFNSHPDGFILVTDAMHLVGLPDGAYPWTNGDTTCNIVKVGSKLLLENSDTIAGSSITLLECVNNFLQWTGTGIPHALRAVTATPAAMLGLQGVKGSLEAGADADLVILSEKQTPGQPSTLVLDEVWKFGTRVHRVVHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C862</accession>
    <name>A0A2T4C862_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1391011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C862"/>
    <dbReference type="STRING" id="983965.A0A2T4C862"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="776"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="605"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="805"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1069" mass="115975" checksum="5666793E3404F7ED" modified="2018-07-18" version="1">MYQGSQRHGSANDPSRPFQVPPPPPPPAMAPPMTGPQMNMMVPPPPPPIRYPAVPGPSQGVMLPPPPSGPPPGSGMMPATNWHGNFGRLYDGRPSYPVPPPPPTNQHQPYNPTKFHQHHALQAGQAMVVPPPPRPSDAMGATYIPTGETYGEGVGIPGFGREETQTSWLASPSQNGTETSTTTPMEERQPAYMGGSHAKGPSTAPGAPTTANAPSSIPPEIAAQWPLDKVLLWLAQNQFSKDWQETFRSLNLHGAQFLELGSAHGGRGNFGMMHQRVYPRLAQECTNSGTGWDQPREREEGKRMRRLIRSVVTGRPVEASKAMPSHSRKESTASSQPPNLAPASSDAPEALESPVVPANSHARRFSQTRSTTMPPANGTDNTNHRTMLKNLEHGRQRYQPPSPAELSPSSTKPSPPTANPPSPPPANSSSSNPKSPGPDLDFTDTDVQFTQPPTTQQSSSSEQGRPPPADDSDDDSDDGLFAIPLAGRGKGKSPTSKPGHAQKPSLTVNTSRAKGKTLSVSFTSPNSTSENADDWSRAGNGSRRTPGTPGSESWESDKEVKLGRRKSFIEKDVWANRPPTDDLLNNLDDFFPNYDLDEPVLEDSVAAETTTSPIAEVEESPQQTAPPAVPAPAMYQDSISAAPASAPAPSPAVASSSQSVYDGDTLGSDESTLKALDRRPSIQTVAQKSMRRSGGLGRMKSIREVARGAHEANKRFTHAQAPHNAGNASTSGIMRRKSTKMFNANIVQIRPDQRGSMIFPQIPQDTLPKRQTTFRWFKGQLIGKGTYGRVYLGMNATTGEFLAVKEVEVNPKAAGGDKSKMKELVAALDHEIDTMQHLDHVNIVQYLGCERKETSISIFLEYIPGGSIGSCLRKHGKFEESVVSSLTRQTLSGLAYLHREGILHRDLKADNILLDLDGTCKISDFGISKKTDNIYGNDKSNNMQGSVFWMAPEVIRSQNEGYSAKVDIWSLGCVVLEMFAGRRPWSKEEAVGAIYKIANGETPPIPEDIQETIGHLAVAFMMDCFQVNPFDRPTADVLLSQHPFCELDSNYNFYDTVLYKKIKETYKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C876</accession>
    <name>A0A2T4C876_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1375288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C876"/>
    <dbReference type="STRING" id="983965.A0A2T4C876"/>
    <dbReference type="OrthoDB" id="4524805at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015725305" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="53750" checksum="33C7092581A2581E" modified="2018-07-18" version="1">MPLGTRPSSSSFALSTCFVLLWSVASCSPHSHTQTETRSDSPPPARGLPNSSKFLPAQIGGIVAAYGVSLVLVAILLLSLSRRRREHLRGSDLPPSYILQPSFPHPEGQVVVPPLIIPKAGHYQSGPYSARIFDPNGVPAPYFLPSPSSSSVVPTTLGVSPLVDQSIVAADRAMAQQQLEEMYKYVMEHEEAKQKGIVLESPVASPNPQRESSASDKSKGLLSKKGKSKPTSLNLAAAKEEKSQSKTSALFSSLLSPKKKTAKGISISSPIMTPMSGTFPQHESREMSAIPPRHYAPPPPPPIPMDQVPFGATNARSGAPITPDISPQSVQTIDERIGASLDRADRSRTTLPYTERDPESATSENSQSPLVGLPSSPRPGSTFPSLPSSPRPGASFSRPNPPSAVRTGGTLPLRAYEEQLGSPYVTAQTTKQTVFERTGPLSPGGGRTPFTGTAVPYSPYQPFTPCVPITPGLVTREDRKRMKRMVPKTPTTELVKSSEEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8R4</accession>
    <name>A0A2T4C8R4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1375610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C8R4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="733"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="881"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1204"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1347" mass="149749" checksum="DDFF562D7BFBEF6F" modified="2018-07-18" version="1">MGSAPVKKPRTGASPPRRLEMLGDAMFPLSSVSSLQLKRDDAVSPLFFSHAPARHFSRPHSVPASDVASAILAHARDETSGVVTTLKLPRASVSSTSAALSGSTPSSMDMSAPSLSPDMRSLPPGLQMLQGVGVLEFLEHDDRPTFLIDLANPADAHRPGLPTVYQNASLRAAQSILALLNPSQENPASPGPTDEFNDFKAWVMATGVDSPNAPSSTYEYGGITWVCTTLRRRFRFISGDPTYRETHAASPMPMMPMMEEEDEEEVVVVQDDSGQCMSTPVTPGADIPEPPDYFGDADAKTTIEATDTADTTPATGLIEPKYDINRRHPDDFTNEVLQSQPTKSTFDWTRIPYSDSLPEHIKLAKSVDWASTPLGPMSEWGYNLRAMANMVMGSPNPAAMYWGPEFVSIYNAAYVALAGSKHPSLMGKRYSEGWVELFDEFAPIFQSAWESGQATMKHDDQLFINRHGFLEETFFSWSIIPLLGEDGEVVGLFNPSFENTRRRINERRMLTLREIGERTASAASVSEFWPQVRKGLAFNEYDIPFSMIYSVKDDAESEVSSLHSGSQFYSPQLVLEGSPGVPEGHVAAPPTLDLRTSDEGFAPYVRQSLAGGGAPVVLSEEDGTLPKHLIEGFEWRGFGDPCRTIVVFPVIPTTTGDAVTGFIVLGVNPRRPYDDDYKLFIHLLSRQLATSMASVLLFEEEIRRGQRAAHLAALDRQELSEQLLQRTQEANELETKFTRMAEFAPVGMFIADQQGHINYCNDMWWQISRHSRSEQIGTAWMDSVRVEDRPDLEAAWTRLLEQKVTISVEFRFNCSQLCGDHTVDTWVLMSAFPEKDPDGSLASIFGCITDISSQKWAEKVQNERREEAVELKRQQENFIDITSHEMRNPLSAILQCVDQIANSIGSFTAHSDRTEVDALLESCLDAANTINLCASHQKRIVDDILTLSKLDSNLLAVTPVDEQPIKVVHRTLKMFESELLAHDIDFEFRVDNSFEAYGVTWAKLDPSRLRQVLINLMTNAIKFTQGRERRAITVSMCATKDISEVTSQGTFYFERNDIQRTVGMDIDNEEEWGTGERFNIHCSVEDTGAGLGDEEMKVLFQRFQQASPRTHVQYGGSGLGLFISRILTEMQGGQIGVSSQKDAGSKFSFYVQSRKCLNPPSQYEHITPFKLERKIQVTPATNGPPVSGPASRCQSDAGRSPLFDVLIVEDNIVNQKVLQRQLRNYGNNTFVANHGREALQTLEKSRFWAGQEDEGVDISVILMDLEMPVMDGMTCARKIRQLEKEGTIIKHIPIIAVTAYARPEQIENAKAAGIDDVISKPFRIPELLPKIEELVGKYQSLSLSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C995</accession>
    <name>A0A2T4C995_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_253245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C995"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="172" mass="19111" checksum="14BB56ED13A19C01" modified="2018-07-18" version="1">MERCGCVPHHVNKCQKPSWLGSLACPARLTQARYMYATYSSICSRFQPNWLRVVFWIGRSASSCDTSSASCERGRFRGKPGGMYNSQSMRLGGLVPGIVGEDGSRHCVSTALGFSLIFLRYQPSLYLPCLVSKGTLCLDPTTETIHMPGQSLFHCERIIRSLNFPDANLSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAJ1</accession>
    <name>A0A2T4CAJ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1327840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAJ1"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="13960" checksum="C75E9C09B61FF85E" modified="2018-07-18" version="1">MPTAGLKTIIALSFVLAVGFLLVILSCALYKVYYPLLVVATYVLAPLPNWICGRCANPDDFVETGGAAVLDLGRFFTGFFVVMGIALPVVLAHSDLIRVEAMIMSIAGGLLIYGTIISFGMFFQEEQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAJ8</accession>
    <name>A0A2T4CAJ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAJ8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015579637" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="59" mass="6730" checksum="87A67BD19F5AAB48" modified="2018-07-18" version="1">MKLVSPLVILLVGVAVAHPLQHRQERECAVYDECFQYPLPCPSNHISRKVNGCYTCCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAQ9</accession>
    <name>A0A2T4CAQ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1399770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CAQ9"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14134" checksum="CAF404B33A069810" modified="2018-07-18" version="1">MNSIIRLARPLLPRIAPLSQRTYTCLSPLRPTLTSTFRPTATSFTPSPTTTATSSEASADVVPAAAVSAHPALQGMQLRFGPRNTMNGHTRLVQKRRHGWLKRTRSKTGRRILQRRKLKGRRHVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAX7</accession>
    <name>A0A2T4CAX7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trichodiene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1352398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAX7"/>
    <dbReference type="STRING" id="983965.A0A2T4CAX7"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="258" mass="28976" checksum="2B3A73007A266D7D" modified="2018-07-18" version="1" fragment="single">MSTKFIANHVRNVVTAMGFGMRKSLKDRDLELEAKLMDKFTDLGLSPTDLEPLEQFFQSICLLASLCYKHNPMDVKAYAAIYTILLLGVDDLFSEGSVICTFAHRFGTHEAQGHPFLDCLARLLRVETPKLFGPFGTNIIITATLDGINGSTLETWFPRGLPKLMPAFSSWQRTWTGYSLAYGCFIFPNVEFPESEYLGRYVQIKPSLRDVISFMNDILSFYKERVLAKEVCLIANLAQEKSISDLASLKLVCDSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBA4</accession>
    <name>A0A2T4CBA4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1437668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBA4"/>
    <dbReference type="STRING" id="983965.A0A2T4CBA4"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="142"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="533" mass="57848" checksum="DCC18408D18DBC82" modified="2018-07-18" version="1">MESGSRARSAASSVSLACTYSATVQTLLSSHTNPPSSRTWTPSSGGFKFPGDVDDVEERELFVNYYNRLAAKNGTSLERRGWFFRIFRPSSGQSSPGKVTPPSRAAHKRSVSDLGAFMRSKPEVSKALDLADIVRLSGKSLLHLPPDYAPCVLNLPTCLRATAHYIAQHADTRGLFRIPGAVKVVNTLYDYYCGARDDASEVSGTVLFATLPTHIQYQVQDVASTFKRFLSCLPGGIFGSLSLFDAFLAIHSQLKGQPEYPRTKQTRLRARLIALAIGSVQSQFRRELIIAVFGLLSMIGRIGEVTPREDDEGRPLPTHDLMGYNALGIVFGPLLVGDLIDGYTVKETTAESGPTLVPISPKKQQRCRDRQKTKEPKEPKDGKDTKDARAAPHDINKAMVAAEIAEMLIANWRDIVRQMFAVGAHLDQGTASTQAPLASMAASMTASLPVDSDAVAVDEGSPGPGASPVSLRRGKTRSSRQGSGRQPSATQLSPTLEEGHQGDADRGRRLFRREPQQPRAIKGNPMPVSKPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBM8</accession>
    <name>A0A2T4CBM8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1389071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CBM8"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="802"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1728"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1728"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1742"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1786"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1815"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1834"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1846"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1892"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1928"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1975"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1986"/>
            <end position="2011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2029" mass="228589" checksum="8829446C0403F8F1" modified="2018-07-18" version="1">MPAFQAINLEPEENLDEQIDTTKELHVDEALKRFQNALKLHAQGLRSREAASAAYDELFESEIFKYREAKTDYERAELQADGQADISAPEFFADGLDVAAGGADGVAANLALALYLSYKNYGQFYLDKLKDEKDADPDWGSKFQLYYSSDHGKKILGSWTAALDQDPSDPELWRKVARFAGALNSGRIKRYCLEAAIELDDDPAVMEVEPPSLAESLAGEQLKMYLNLLGDDMALSHPAMAPWIKKKLPKLLKRHLDPIPFLPDPTATLSMPAELQISKQLLDNGVADGSVTISNDSDMSSRNVESWSALGSELMKCAESTKDALEICRLILQTAKQDTDMDEPRDEAANGPANGTLSEDKKASDAKSSKTKASPTPPREAKGSQASDGADDAAKGSEAARKESNATQSARKRSQSAAGLPDGADEENVTEKRSKRVRRRAETTQTEEAPDPSTLIANQLRPFQEADQHLFAMTKHLLEVIGLEDKETFDYLEEMLNLCAAEDRSSKFTRTGAKDLRTLIADFKEDVAMVFLNKKEQATLGLSSFLEHAKSGSEDQAVNVPFNETKGLRDFALRVEERGEQMTSHDVIFEWMKVISSSYASFKWSDDMKRTVVQMLNAADSSLYTLVSEALRTESSPEALAELESLVPMVFELYIDIYERITNPSSAVDYATRMETKYRLQRWLDLASAYVRLMNRPATDPLCVRFLWASVLVSSLSDNPVREHILLLWTSLRDFLTEEKVEPLTLPNNVVMPTISPAAADREISKLTTMDFFLSLFQEGMESPVHVIETLEPVLNPSSVCISAEEPDESPDSEASSPPESEEHQPQKKKRCISDCATQGMRDLWKFLSSSSTELRLFLWSRLGDAYEAIKYTTKRFSCLLRSIELIVADLESEKYAKLPDESRLLLYMRTLKSLDELLIQALTLALNDSSAFDIIDEDHLKSSCSAIAKVNSILHVAFLYEDEVKIGVKTAPSSNSTFQSLITKLREMQVRTWSLQFTMFRAALPLHDSVDSEKELADFLAAIHQVIGLRKCCKASNKIFLKVMRMELLKNKNIENWEDHLPQVVYDLYGLKLGVGAWEVQDHGCPHEKLEKRQTMQLVEKVMILANRMPMKDLLKSDLKTAIDHMQQTIGQPKSTAQMIHNLRNFTELVKKPIHPLRLYQALAGEVTVDAVSTNTPEAALAKYGWFFLLGMIALTKFKAVDLNRRQTPGATDDLRIGATFLRLQLQFSSDSWESWFRLAECFDYDLDEAVLWTADKMNKDRAELVKFQRNAIHCYTLALSHSRYQQIEATDEDPLHDLYHKFGMRLYASSREPFAMEPFQHSDQERFFIQNMGSGTFKRILHEQMTEYKVWKFAAKLFRMAMERKPNNWKNPYMLAKCYWKMYQTPDEELDSKDRETKIGINTVLKALKDAVKVAQNARRSRHSDPILEPHYKIVSIVHKLVMRGDLPAKEGANILSEQPFGVQFKPDDVFASFSEPADWTEYIIPTLVKLKEKDKSNWQHRIVARHAKILFDESQGAQVSDKVAAQAAFAILRENMFTKTMVMNVWKCDAERPGRHHVFTEQYVRFMTNLLVVMTDKTNLEQLLRRLRKKGADFYHFVDLWQSCCMAYLKLLRDAHDIPHPTDDAFKSLSTEEFEIISERIAEWATRDEANVPAFICMKEAIELKKLNANLMKVAGIDDLINDCYAKIYVDIAATLPGQEPSKIIEERNQAKEIAAKLEAAAHAEAQAQAQTQAQTQADSKPTSSLINILNPPSTHDSLPGTATPLEGEKSEAAPRVRKTGVRRPDVLRKAEQAVTRSLETPKSALPRSRVGSMSSAKRGSQTPNAGVSDVDSDDDDEGPDAQVRREAGEDTDMPDTHAYDEDGHDGHDDSKVEDKEDLESDDAHTLEDSVDSDLSDVPEDYEEDVPPSLMFPHLGRTLQSGETSGEDADSESEGDEAEEDEDEEDEEDEEHHGEDEAEEAEEAEEGEEEHEGDHSKEHLHDDEEEEEEEEDEDEEGGHEDEPEDAEMAEPHTPGRGPDDSLDMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBW0</accession>
    <name>A0A2T4CBW0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBW0"/>
    <dbReference type="STRING" id="983965.A0A2T4CBW0"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22815" checksum="9747FF4D93E551DE" modified="2018-07-18" version="1">MTKLHHWENFARLAGTTAVPWPKGSLKDALSCHFCTQKILQADQTRLGKDFTAWDLNCIGNVDIRWTTNLADHLRFVDEDQAVFIFHCVSFLQVHKSFTEIDPQLVKCEPIERHKLRLGDFNHWHDRLVILKQVLDESTPSTLSQRWHDVRNCLRWYTFWIAIPLFAMTFLFWIVHSVEGAVQIYLTCKGFESGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCH8</accession>
    <name>A0A2T4CCH8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">17.2kDa subunit of NADH:ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_47798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCH8"/>
    <dbReference type="STRING" id="983965.A0A2T4CCH8"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="211" mass="24522" checksum="2CAC9306DC449E0A" modified="2018-07-18" version="1">MTPKQIGPFAQAWYKWKALRLPWRRRFLIGFDLQGNTFWEFRHHRGAQDAGERWRRIVDYPRSTHLSQVKVSPQWHQWLRHARRDPPSLDEQRAEAARQERIKLLAAQADARWEAKPRVMEDPRARAAARTGRLPLAGEEDGEVVKAAEMEEIPNTSAEPARAHRTEDETPKTKTKVKQDVKDPWARAAPHGPGEQWQPAAWDPSAAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCK4</accession>
    <name>A0A2T4CCK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1398574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCK4"/>
    <dbReference type="STRING" id="983965.A0A2T4CCK4"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="10">
        <location>
            <begin position="320"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="443" mass="47875" checksum="E7D7F004EA3D50C7" modified="2018-07-18" version="1">MSEDITQNDGVSAMRRPKPLTVVIKLGTSSIVDENTHEPLLPILTLIVDTAVKLRKDGHRVVIVSSGAIGVGLRRMDVAKRPKHLAQLQALAAIGQCRLISLWDSLFAHMAQPVAQILLTRNDIADRTRYLNAQSTVNELLDMGVIPIVNENDTLAVSEIKFGDNDTLSAITAAMIHADLLFLMTDVDCLYDKNPRSNPDAKPIEIVEDISALEADVSSAGSALGTGGMSTKIIAARLGTSAGVTTIITRSSNPGNVLSIVRYLHHQPTKSSSSLALNLMAQSEPADSRPAPPLHTRFLASNDPIRDRHFWLLHTPNPHGTLYIDEGAHKALLTKAGLLPVGVVDVEGNFAQQEVVRLVVVNRRSFPGPDGKRWEGLGVEVGRALVNYAAPEIARIMGHQSTEIRGILGYADSEYVAHRSHIGLFRGESGTATPTRELRSPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCW3</accession>
    <name>A0A2T4CCW3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1398661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCW3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="9456" checksum="FBB31EC0714AC221" modified="2018-07-18" version="1">MGFWLVGSAISAPETLSRSSFDWSWYDFQCRRFGLMQQRAGLLWPQLAFAVRRVWEASLLTALSKTGLASNESECSSLFNDSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD12</accession>
    <name>A0A2T4CD12_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1326349</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD12"/>
    <dbReference type="STRING" id="983965.A0A2T4CD12"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="658"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="258"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="445"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB79467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="710" mass="80908" checksum="6C4E3E197DE226ED" modified="2018-07-18" version="1">MEDRKRPAISGGEDLAPPPSKRVAINGSKAKDENAEMKEDYWVEAFTKGAIYRQMQEYSRKAATAEARLEELHKRSVHHDDHIRIVDAWWRQMLEELELLVESAISTTESRDLQYSYVSGIAFKDLQHFQSHLQEMGKSIKTKAESLINRLAAQRENISPKTTELESQIANLLAKQKEYHLNLDRLSAEKEQLSEQLNAATLRYFKAEKKLDRAKSAQVQRLEQQAFANATRPVTTPTEGGSEPSEANGNALEITMKYEEAAATVSKQKEQLDSLFAELKSLQEENTTLKSRRETLSDEDYIRTDVFKQFKSQNEELIKRVNTLEASSKQLREEAEKFQAERTAFRAQLEADMNQVAQDYEADIAARDQDLARVRSARDEILAENVQRRANAEQERIAMEHIKELVAAKEDRISALESEVARLKPASPTEGEEASAGSDAEALSEEELRQRYKKLKQDFDSINQELPAMEKAYKKMKDLAQKKVLDFVALEEKVAVLIAEKAKADQKYFAARKDADTRNGEIRTLRHQSVKSAELIAQLKDFESQTRTLLTNLEKQLADLKQANAVLVAENKKMEASSLEAARRSESVAKQVADLTNLVKSKDSSTAIIRERNAMREVEVEKLKIRIEHVQKDRDSWKNKALSNSSEEEDMLRTMALCPVCHANFKNTALKTCGHLFCNKCVDDRISNRMRKCPSCSRAFDKMDVMQVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD91</accession>
    <name>A0A2T4CD91_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1172160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD91"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="134" mass="15132" checksum="AEAE0EA869D578D4" modified="2018-07-18" version="1">MERCMKRMQFLAPFAAPSAGSAPYYMLLSGDGVGALHSGVWCGVRTKVRFIVHHALCPFFLRCGRTIYYIVRLEDAASVARVGRRWCFVSQAQEEAPLWFHLFWASASEAWVSPDNSIDSEPHSRSSYLVRSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDK7</accession>
    <name>A0A2T4CDK7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1327114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDK7"/>
    <dbReference type="OrthoDB" id="4923153at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="134" mass="15171" checksum="A21FDA489406E289" modified="2018-07-18" version="1">MPGRVTLSRSSNSPDPASTVLEAEKLLRKIKKDRIDGIRAVMADAEAALAEVRERVTSWQLELQQQREKRRLDCVTKLIELEDRKDEIENKMGDIGAKAHAMVEDLEAMMMAGYEGREKDATLALEKMTLNRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDS7</accession>
    <name>A0A2T4CDS7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_245276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDS7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="15828" checksum="F17E458BEFB80E53" modified="2018-07-18" version="1">MGHRLFVLKEMRHGAYQMYFLFLRVISLLYQMATGRQSLSFFGLGFALSGLPQLCYSCRHAYRYAPYGADTLKQTPPYPCREGKALWPNPTTGCPPCIRRLLIGRCMQSVSYLRHNSIWLYISCQAAHYCLPSCQQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDU8</accession>
    <name>A0A2T4CDU8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1326942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDU8"/>
    <dbReference type="STRING" id="983965.A0A2T4CDU8"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="588" mass="67020" checksum="A1A5269A2940E2C0" modified="2018-07-18" version="1">MGWDGEEDGETKRQKHISFEDGSLDGSDEDEGAVEVTFDNGNPYRRKSSLVTSEATVPRTKRIPPGQRAECVVHQLIEDQRRSRHSSAASSPNRNQYRAHPIYTHPNHHESAVDISKERRMDRIIDLKSPGDQQKCRAVVDTECLSDEDAGLGQVDQKVWTKEMTKTDSETDLTHHTSYENIHSRMLTKKQLSDMAWGVRELSRRLSSMRIRFRVKTIFLLTKIHDSDLICNTRALAQWLLSKDRDVKYVVYVEKILKTNKKFDVGRMVDDLVRDYAKEGGVDEESARDDIQKRLRYWDESMCRARPHQFDFVITLGGDGTVLYASWLFQRIVPPVLSFALGSLGFLTKFDFEDFKPILTSAFSKGVTVSLRLRFECTVMRSVRRKTPEPESEEDSDDTHYKRDLVEELIGEENEDERTHRPEGTYEILNELVVDRGPNPTMSYTEIFGDDEHFTSVLADGICVSTPTGSTAYNLAAGGSLCHPENPVMLVTSICAHTLSFRPIILPDTIVLRVGVPYNARTSSWASFDGRERVELKPGDYVTVSASRYPFASVQTEGRRSEDWINSISGKLGWNTRQKQKGFKEWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE54</accession>
    <name>A0A2T4CE54_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1327398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE54"/>
    <dbReference type="STRING" id="983965.A0A2T4CE54"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="6">
        <location>
            <begin position="106"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="324" mass="36118" checksum="12797636FB5625F7" modified="2018-07-18" version="1">MPPLLLRPHATLSHAEALQVAQQAPEFLRKNPASYSASPLFSLFSPPENSKTWTIYENLLLACLRTGDYTTAHQCLDRLVIRFGVNDERIQALQGLVKEAEATDNSELENVLKEYEAILANDNTNVPISKRRIALLRAMGRTAEASEALVQFLDFATTDAEAWIELSDLYLSQGLYAQAIYAQEEALVIAPNAWNLHARLGEMLFMAAESGSDGHPQAHLAESLKRFCRSIELCDDYLRGYYGLKRVTDKLLDKDSRPKKPSESDDVVLPETSTIEQLNEAATKKLGEIVRKYDAKDPLWQGYDSGEVAAARACLSESSQKIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEG0</accession>
    <name>A0A2T4CEG0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEG0"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17515" checksum="3E474031A84E1565" modified="2018-07-18" version="1">MAKSSLSISYYAFTALHFACFALAITVCGLYGANLQRTKNFDNYTKSKWVYAVVVGALTAATCALYFIPFIIEAGGIFIASWNTILFVLWIALFGVFGKLYIHENAHGNGDVERMKHAVWVDLTSALLWLIASVAAFAYWWKHRNTRTRFTGRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEH1</accession>
    <name>A0A2T4CEH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1427799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEH1"/>
    <dbReference type="STRING" id="983965.A0A2T4CEH1"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="378" mass="40191" checksum="1D791843B03A34B3" modified="2018-07-18" version="1">MCATTVKASVLHGERDLRLEERSLPAPSTDEVQVAVQSTGLCGSDLHYFGHFRNGDILVREPLTLGHESSGTIVAVGDGVANLKPGDRVALEVGLPCENCEFCNSGRYNICRGMKFRSSAKAFPHMQGTLQERINHPARWVHKLPESMPLDLGALIEPLSVAMHAHRRANLASESTVLVFGAGAVGLLSAAVSKANGASAVVVADIQKDRVDFAVANGFADAGFVVPLARPQTVDEKLAYAQEVAEQARGVKVNGEEVGEFGAVYECTGVETCLQSAIYATKPGGKVMIIGMGTPVLTVPMSAAALREVDLVGVFRYANTYPAAIQMLSNKPAGLPDLQKLVTHRFKGLDEVTHAFEMAGKVKDGEGNLVIKVVVDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEJ2</accession>
    <name>A0A2T4CEJ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1347554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEJ2"/>
    <dbReference type="STRING" id="983965.A0A2T4CEJ2"/>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50053" checksum="2F5FEDF00F2D3F41" modified="2018-07-18" version="1">MVQPATAPEHWTELIAARRQRRLLTEQVEALKRSCASECGKRHVSECPKCWPLVIDKMRQRYSEGSDREWFTSRTALHRELEVLFAEAKEHTISIQQIEARIESEKEAWYRGILRKHSEFLVICNDDFVHDELRGMLDDPDRSREEVVEMMWRGIGKPPDWAERVEAFVAKVAAAGGNPAALKKLYVEEFFLNKETGEPLEDSKPYLDEYLSNESMGIEEILGKIMKDAQESRNLRPQRDMHTARLDDLRRAKMADELNKKQQAKSQAQAAQERVVGEDLYNLPPCLVCRKSLDTHDVFSCPICQAVTQMGGKKELTVFCSEECHAAGFDDHASEAHACESGDNCVQEHSEGQVEDVEMDDGVPQDGFICRECLVLKRVTAFCSERCAFENVVRHYKRDHEAKADADEVSSLVRPMQETLESILRRENPGLHMEWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEZ8</accession>
    <name>A0A2T4CEZ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEZ8"/>
    <dbReference type="OrthoDB" id="10620322at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="511" mass="55326" checksum="31EF62FB526C99D8" modified="2018-07-18" version="1">MAEMIPLQAAEASSHPGTNREPLLSARAFPMAHNIASSGTAIVNSDFRGRHDVAISPTAVASTPRGPAIVVSDPRALAAATALREGHNIPTTVASVPRGPRAQHAGEASQAVAGIRHVAQILQHPEMAQRPSLVAQGFHDSSQALLNAPRGPRADYRPFHAQSNAPPNAPRGPRADYRHFEPPRIAPQAPRGQPWRYQTPLNDPQAYRAANWQHPNRPNVFPENISTSQTPQNGFSAPQTAPRAPRAMQTLPPAPPWSSPMAEPFVGATHPTTYPYSLYTSPHCPTFYGPYAYSRPANYQYMEEQPYYEVLQDHHQWHASGPGNGGPPNAAPPETDDVVRHGMILRFLDSLPPPPSNPEFPPDPPQLYLKARHRRRNRMQSSRGSGATAQTGSTQGTTAITRPVVPPASADVTPRIAQRETYRRGKRGRFGQQHESGQRSADGADLLGELEISAETVVAGAAEVAESADVDNVVETPENVEDNGEGEECEECNDEDEEADDDCASAATCMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF19</accession>
    <name>A0A2T4CF19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1113298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF19"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="137" mass="15529" checksum="135D6CAFC0DB9B1F" modified="2018-07-18" version="1">MHLQIDRSWVEFVSTVGLIFPSLLFFAHPILPTYNTILQFIFRFYCNRFFYTSPSTSFSSSVISAASEGSCYFLNILAPILLYRPRYLRPSLLPILAASTHGNLHLNIRLSFPPFSPLEAFSPPLSSSFSRSTPFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF82</accession>
    <name>A0A2T4CF82_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1397530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF82"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="82" mass="9392" checksum="C7E115297B55FD57" modified="2018-07-18" version="1">MFTVRRTAAITTPSTLQALIATTTCFVRYRGGPRGYDTVKTMVQAMKEQTIMRWRPVRPHNPVSDWLCSWATSWPHCRAHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFI9</accession>
    <name>A0A2T4CFI9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1121967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFI9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="18531" checksum="93672BAC5BBD1864" modified="2018-07-18" version="1">MEYNSALLAATYSLSYGRCISSNKGLIRLRDPSGVQVSSASEPSPASILTSWGSLLICSTHRPPFSRKINDYYSYDLPLSAEHRHSRSRTSELIRRRLCRSNYVFVVHKLVATCYPSALDYGLYGMTFTALLSWMRPEPAAALQVRLSYCRYRRDGRTRCATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG73</accession>
    <name>A0A2T4CG73_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG73"/>
    <dbReference type="OrthoDB" id="5221152at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="72" mass="7397" checksum="1D6D9297240F397F" modified="2018-07-18" version="1">MPSSAPPAAAAAVPAPAGLGDNKGIKFQIKTGNARWECTLQDRSAYERMKAQRSDSTDSNSSTGSTSSAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGH3</accession>
    <name>A0A2T4CGH3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1131143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGH3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="247" mass="27221" checksum="00F38116005A78BB" modified="2018-07-18" version="1">MQRRGLPPIRWRAGAPQTPLERAPSVDVLGGRCWHSSGSSGCATAPSLGSLALASPPPGSAATQPYPEELNELGLSWALLPLADEQLAHGYKYRAYSTNAYEDHPLSLILISSSPIFHSASRFTALSARPFVSAIVRLDADESWPLARVISYRSRPSISPGLHPVLNSGLLPTATTALNYHLRAPDQKRKRTQSTRESIEDLERRNFSKSKEDIAFARFSRREALCRLASKPWEAALPDLNHTIFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGI0</accession>
    <name>A0A2T4CGI0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1419217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGI0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGI0"/>
    <dbReference type="OrthoDB" id="4900680at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015406911" evidence="2">
        <location>
            <begin position="18"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="261" mass="25533" checksum="65DFE829334D32C8" modified="2018-07-18" version="1">MKPSSILLLAAAGLSSAMPAKPFHKDTRSLFGHHAVGARALVPLNANTAAPPPPPAVDPAVMQEIPTPTDQKADDAAAATTTAVVATEAAATTTAVATEAATTTAAATEAATATEAVTTTAPPPALDTGAAAIGNGTAGDNGKGKGKGNGKGKDNGKGNGNDKGNGRGKGNGNKGNKGNNNNNNNGGLGDFISGALSQLGLDGVLNAGAIDKLSAGDQISLLAQIVSLQTMKDLQMVDGKKIAVVLNQGFKSAGLNVAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGP6</accession>
    <name>A0A2T4CGP6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1419287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGP6"/>
    <dbReference type="STRING" id="983965.A0A2T4CGP6"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF19">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="633" mass="69000" checksum="B3B73AAA670623E6" modified="2018-07-18" version="1">MPPPTPSKPPQQVCDNCRFRKMKCDRGLPCSNCVVSSIPCRYLHTLRRKGPRGGKGRRLSQIRQGLTEPDRNHFEVSTPGAAQQQMQFGVLEEASTAAGRCSSSRSCGGAAGGGGGGGGGSQQQQQQNSLLALATATEHDRQRLSVALAAHVQVFMKHLFPIMPVVNDRELLADSLRLDALSPSRYAFLLSLCAATRIQLKLDSADEYDETVVGINTSLDSPLTGEALLSAAEQARLRFNVVDDLSLDTLLTSFFLFASYGNLEKHSHAWFYLNQAISLALSMGLHSEAAYGSLEESERETRRRIFWLLFVTERTYALQHRRPVMLRNTIAKPQIVDSDCPVVMHDFVNHARLFELLPCSLYEWQPHADGCCQPQGVALSRAVSDRLSAAVRPAESVMESQRFDTLVTQQWLRVSMWRLAFGSRPGLAYGGQQQQQQGSMMPALGLPFEAGRSIMKALGSVSQSSKDCHGIAIEQKLFDIGMSLADASMSASPPIPSFEFGPHDLLCSVVKFLGRIRGCQSNLLPKLLRHSELILGFSSSSPLAGIDIHWPALLEEEHHHHHPSAADVGDHLAHHHVQQGGESSSASSSSSAGSWQDTCDLAMLEPGAGGFMGLGCEEAFEEQVHLAGQVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGV8</accession>
    <name>A0A2T4CGV8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1460603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGV8"/>
    <dbReference type="STRING" id="983965.A0A2T4CGV8"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="17935" checksum="6BD9F62BC480E917" modified="2018-07-18" version="1">MSEQPMLEIRTDTAGTGKCVVNLLPCRVQHTGPTGPSSAYWNPSVDDNGIRTAYLRGRRLQGKTASLPADYRGVVLQRKDDETEPAEQPDVVMVGDDGDEESAPKLGTMHVVTEFDKVVVWSHDAVADASSDPYLRSVEEWFKVADSVSCALKQLQRNDGLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH12</accession>
    <name>A0A2T4CH12_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1321635</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH12"/>
    <dbReference type="STRING" id="983965.A0A2T4CH12"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="399" mass="45279" checksum="55B24C4FFCF526A7" modified="2018-07-18" version="1">METTKKPLRTDEKDAAHADGTVITNGDRDYLDNSEDRPYPVLPDDGQPQSYEFGAWRAGGIRFAPLRMPFPRRLQTAAVFFHCMTIVVLISMFWFTCANPLSWPLLVPYLVHLSVSNAATDGKLSYRSEYLRSLPLWRFFASYFPMRLHKTHNLPPDRRYIFGYHPHGIISHGAWSAFGTNALGFAEKFPGITNTLLTLESNFRLPFYRDYILAMGMASVSKESIRNTLTRGGPKNDGRGRAVTIVIGGARESLEAEPGTMRLILKGRKGFVKMALRTGADLVPVLAFGENDLYDQLSPKTHPMVHKFQMFVLKVFKFTLPALHGRGILNYDVGLMPYRRPVNVVVGKPIRIDVEPCEQPLQEDVDRYHDLYMAEIEKIWEAYKDQFAKGRTSELVISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHP4</accession>
    <name>A0A2T4CHP4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1417812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHP4"/>
    <dbReference type="STRING" id="983965.A0A2T4CHP4"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="306" mass="33057" checksum="95D101B50177E85D" modified="2018-07-18" version="1">MAAAPKYLTGDAAGTKEFIDKFDTFLFDCDGVLWNGDHVYEGVPDTIALLKSKGKKVVFVTNNSTKSRQDYVKKLEKLGIPCDAEDVFGSSYSAAIYINRILKLPPSKNKVFAIGEAGIETELASEGIPFIGGTDPNFRRDITPADFQGIADGSLLDPEVGVVLCGLDFHVNYLKLALGFHYVQRGALFLATNADSTLPMHHTFFLGAGSVMIPLANALGRQPTVLGKPSQAMMDAVEGKFQLDRARTCMIGDRLNTDIKFGIEGNLGGTLHVLTGVSQKADWDREDAIAVPAYYADKLSDLLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHU1</accession>
    <name>A0A2T4CHU1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1008373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHU1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18330" checksum="D6AF753F3249E8F8" modified="2018-07-18" version="1">MPPRGEEGEGGRPNGEGLTGQKGRKGIFKGSKAYRVQEDQSTNSHWRQATLSLTRGGERDPAANREQSARKKKVVCVVNELSLVGKCVCVCVVARTTSGMPCISGRRVSERKEGERGCGWTRWGKGWRVAQTRDHREASLVLVLNLTLHCLPTASRKHTQRIAHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI35</accession>
    <name>A0A2T4CI35_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_45677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI35"/>
    <dbReference type="STRING" id="983965.A0A2T4CI35"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001834">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="256"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="478" mass="55155" checksum="0F0471B46BE47D33" modified="2018-07-18" version="1">MPPLQRASSCTDIGFTLRRQFHKDDFRPHQREIIEAALDGHDVYVQAATSFGKSLCFQLPAVIDQGITIVVSPLLSLMINQVEALRAAGIDASSLNSNTPLDERDRIQRDLETGHPRTRLLYVTPELCSGSRFRERLQLVHRQRELARIAIDEAHCISEWGHDFRKDFKRLSWFRETFPDVPIMCLTATANAQVRQDILKVLRLDATPERIKTFLMSPQRSNLHLEIRYTKDEDDNRLSDFLKWIHGVYDRRRAEPRQSELVKYRERTDNVSGIIYTMSRDECESLSASLRDAGIGARPFHAKLPKDVKEDTLTKWINNEPGYDIIVATTAFGMGIDKDNVRFVVHWRLPKSFEGYYQEVGRAGRDGNASYCFLYYSREDLERVSRMIKSDTKADSNYESRLRSLQALAYYCENINACRHASICKYFGEDKIPECDYACDFHKDPDDLEDRFVAGLASEEWVSTQAMQGTYDNYADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI55</accession>
    <name>A0A2T4CI55_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldose-1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1322670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI55"/>
    <dbReference type="STRING" id="983965.A0A2T4CI55"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015468077" evidence="4">
        <location>
            <begin position="24"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="406" mass="44586" checksum="4A1135DF88FCA754" modified="2018-07-18" version="1">MQLTGSSLAVFALAAALPLTATAAKSGSGPDKDGKYWIRAKGIEASFIPYGASISNLFIDDRYGIRRDVVGGFDNASYYGIDAQHPHFGGVPGRYANRIKNSTFSIDGKAYHVLPNEAPTEAEPNGTDTLHGGPDGWDWRNFTVTAHTPTSITFSIVDPDGKEGFPGEVVSHITYTVKDHQWDFKMVALATTKKTPIMLSSHTYWNLDGFANNETQTALNHTLHLPYSGQRVDVDGYLIPTGDILANKKGTANDFWSKPKQLGKGFEQSGIKNNCGNNCTGYDTCYIVNRDALQPFDWRTEGPVASLSSAWSGIHLDVYSDQTAFQVYSCNSQDGTLALKKTQGLHGNKRFPRTIPQYGCLVMEVEDWIDGINNPEWGRKQIYGPGDEPYVLQASYRFSIDGKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIM7</accession>
    <name>A0A2T4CIM7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cellular morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1387840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIM7"/>
    <dbReference type="STRING" id="983965.A0A2T4CIM7"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="231"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="4">
        <location>
            <begin position="389"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="902"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1229" mass="129568" checksum="16BF92F6644EC247" modified="2018-07-18" version="1">MRLSSQRRRATRRPRLSSTSIATLAAIAPSLSRAFNITAAPPANLDFSQLGSIGIAGDFNGISLYQFEEQIARPLSTNGSEYLLTQLPNGVLAPIAATDASILAMCSVTLEDGAEGVVLGGNFTSMDGIKSTAIAIYNTNTTTFTPLEGLEGEVNALLCDDDKGIVYVGGNLKGGNSTNAIAWKVDGNWTNLPFAGFNAPVSAITKASNGHIIFGGSFTGLGNVTAPNKADGQAINLSTAKISAGGTSSTQGFDDPKNVICTDGSGGSGKTWLLKDGVSGSWEAAFDFGFEPTKLRLWNTHQDGRGTKTFRFVALPINGIMNFTYIDPATGKNSSCTSECPLSNDPKVQFQDFHFVNSVGMNAFQIDISAWYGKGAGLNGVQLFEDNMFSYAINSFNEPACNITFPSSASATGPWKQSPSLQSDSKYLTAHLTSPISSKSASVVFSPNIIESGNYSVNMYTPGCVPDGSCLTRGRVNITGIMSSGNTPSNFTTSIYQTNNFDKYDQIYFGYIERTSDSFKPRVTLTPLDGQDLSEMTFVAQKVGFTLLNSTGNLNGLFDFDPSQNKVNTTSLNDSPVNQLGASFDHNTGVKSLATSGDITYIGGNFTSDAHHNFVAIDTSGKVSSLNGGLNGQVLDMYLQGTQLFVGGDFSNLRSDGKAGLNHVAVYDTKSQEWSALGAGVNGRVEQVVAFQVNISSVTEDAIALTGSFTECNAFGSFEATPAQGFAVWVLSRDNWLQNLQGPAPNFGGMLTASKLNLTTGNSLFAGSVESSQLGANGAVMLGDQGLGQFPVQIQPKAQQAGSKRRRDLSTEPTSGVLTGAFYTGNSSNITVLAGHFSARSSNGSTVENLVIIDDSDNGTVSGLGPGISSESVFTSLVFHGSVLFAGGNVTGTIDGSSVSGLIAYDVVSKSYSSQQPASLLGGNQTLSVVTVRPDSAEVYAGGSFEKAGALDCPGVCTYDADSAQWSRPGSTLAGRVSSFMWFSKTQLIAGGDLRTNGTDTGYLAMYDVKKRVWKDFAGASQIPGPVSAITPGSNDNGQLWISGNSPNGSVFIMKYDGKQWQSPSVLPPSGSVVQSLQVFTVTESHSKADLLDDRQVLMLTGSIPFPNVGMASAAIYNGTDYLPYALTSTDTGAGSIAKVFSQKDNFFTSSGKHLPLVFVVLIGLAISLALIVILVVSGIILDRIRKKREGYTPAPTSMYDRGSGIQRIPPRELLEQLERTRPGEAPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ27</accession>
    <name>A0A2T4CJ27_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_63423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ27"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ27"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000899">
        <property type="entry name" value="PHD finger and BAH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="9">
        <location>
            <begin position="136"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="559"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="667"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="854"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="951"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="960"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1180"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1247"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="138847" checksum="345386A67AF6DAE0" modified="2018-07-18" version="1">MAKTSPSSGAAEKEAVIDVAMPYGTRSRNRTAGSRPNYAEDKDIEMDIRAQERKLEARHTPNTVDTADLDDEPLDEDEDDVHGCQTDRTSPADDDAPHQGTAEQIYQASLWPWRYLGMHCKPEDALDYDDRIYPRAGTRIGPRNQASVGPWPGQPVQYVKPLEFKKGSKKDQKLLKEQQEAERARRVQRPKWVQDQPPGYVARGEDLDENDPNCTAVPLWKPPPAGEPPVETINDYVADAMSKAKQLDLPERSTNLRDVAVETLFREGYDPSKALSALVEKPRAEFKEPSFTPAEAKKFEEGVSKFGSELHLVMKHVKTKSPGEIVRHYYVWKKTERGAQVWGSFPGRKGKKQAKREDAAAHKLADDVAHDDDDSAFDADKAAQKKRSFICQFCNTTNDRQWRRAPNPLPGLVNEQGLKGSGKDKAGNQYVVALCRRCAELWRRYAIRYEMIEEVAKKVAQAGGRAWKRKQDEELLKELQLAQELGYMTPERAPTPSKAAPQPSETQEPPRKKLKSAADKEAEATPSESGSTPSAVPTKKKEKAAVEPPAVPEMPKPRTLPCAICDQMEPMGDQHLSCRECRLTVHRNCYGVIDHKVQGKWICDMCANDKSPQVSIQYKCVLCPVEHTEHDFVELPKLTHHKKKMSEKDREREKLEVQQARKAAEFYRKKQEDMNRPVNPREPLKRTADNNWVHVTCAVWTPEVKFGNAKALEPSEGIPSIPRSRYDEICQACNQQGGACVPCHHCRAPYHVECARQKGHVLGFDIAPVKSSRRDQFNIVTVNGESGTMSALLWCKDHLPTKTIVHRIHDVVNESGLNALQLYVQNFKQADLTLTGTVRKATLMAAAARLSGAPVQTGNRRASTTTAPNGTWTQPRNTEVVDAGSNAQHPGEKVCITCGIDVTLRWWPIDTSQERKLTNGHHGTIGLEAQKFVEQRRFQCHKCHKLRKAPRSPRLTLLPGPSPPPAAPPELPRPQPMETIMTPVPPLRGATPPAPPVDYRDGRHASHPLSWPQPPSSHAMPPVSTPPAIPAPVHAPAQVAPHRPPPVTHAYPPAPLPPTRPAAYSDWAPHRPGSQHNSPPPPRHINGGPPPPLLHSAPPPPPPISNLSALRPPAMAGPTMPVSHQHGHSYANGLPSSPRRMSGPTAPAPYVPPPYHAGVGHPGHGGPVHPPAHLMNNGTQPPPPPPPPRTDAFSHGLHPQRSFQPPTHASPPLLRNGPPPPPPPAHDAPPPSAPMAPRPPESRPATGASTNPSLRNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ30</accession>
    <name>A0A2T4CJ30_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ30"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015772412" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9067" checksum="04AC9C72CD589226" modified="2018-07-18" version="1">MPWLPIGLLLLCCCYSIPCGKSIRLSARVRVVGTQSKKWWRCVRDQGSSSPSRWMAEGSPFALLEWKVECIWMPIWHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJE9</accession>
    <name>A0A2T4CJE9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate dehydrogenase dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJE9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJE9"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydrogenase dimerization" evidence="2">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="335" mass="37783" checksum="E6CC80632EFA27EF" modified="2018-07-18" version="1">MASAQTSQVPAGMENFTVGLIGMGDMGRMYAEKLSEAGWRCRAPRPTPTVLGCLRSKYVHLTAQEHDRITADTQAVTHAAFLSMGKAWHANTQYPWELSRYVGGIENVKMNIMLRIYSQKWHVYAGLAILNPEARQQVAQYARSVTELYKLMLEGDLAGLTARIYAAREKVFGPSSNAWASRPLIEPSILSSFSLGTPTPETPARPNNHLSLLAMVDCWAALAIVPYDHMLCSTPLFRLRLGVTEHLFRNTDMLDEALRVAVHDKRYRSDDLEFTFAARGWAECVTLGHFETWEKRFVSTQEFFQPRFADAKKVGDEMMKKVQASMDEALKLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPV0</accession>
    <name>A0A2T4BPV0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1452167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPV0"/>
    <dbReference type="STRING" id="983965.A0A2T4BPV0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015376738" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="38"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="561" mass="61481" checksum="1DA8F8EB00E9AB5F" modified="2018-07-18" version="1">MFGHWSIDVCSVVLLFLSSFSPAGAAAVHHQRAPSAHTVNGTYTGLSLETFNQEAFYGIPFAIPPLGDLRLRYPVPYNQSWTDTRNATVRSDSCPGFDKPFAQGFADGLTMSENCLTLDIVRPANVKPGDNLPVFFWIYGGGYKAGGSADPRYNTSFMVRNSMEMKKPIIAVVPNYRTGAFGLLASKEVAAAGVGNIALFDQRLAMEWVHENIRAFGGDPTKVTIAGESAGGSSAGYHLVAFGGKNNGLFRSAILESSSLLGATSESGWYNNITTTVGCNTAADSLACLRTVPYPKFFSAINGFQFKPYIDGKFVTQPPSVSIAKGQIADVALIMGSNTDEGTAEFFTPRGTLNNDSDIASLVAHLANGLSDEIVSNVLRLYPDDPVQGCPFGTGPERFDDQGVQYKRGAAITGDLNIHAGRRAYAVSHSQRSKHPIYTYRFDQAPWDMKEVDVTTTAPVFVTHYSEIVHVFDNPDKNVNWIGPYPILSELANYVSRSWVSFIHDQNPNNHGLQDKPVWPRYDASKPQNIVFRAGASWIEKDDWRKEQLAYWSTIWSEVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ76</accession>
    <name>A0A2T4BQ76_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bax inhibitor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1395591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ76"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ76"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20554" checksum="5419E31EE1359CA2" modified="2018-07-18" version="1">MEHMGLESLTRSIWGFEAQDKEVCGIWRSCGGKSRGRPRYSVIPLPHLRPCPLVPLPLFPVVPPLLPPDTPQLPGATAKQEKYLYIGGPLLAGAAIVAASGFAPLLLPATAVRTLAFTESIWLYGGLAVFGGFTLYDVQKVLHHARLAQAGVIKRDPVNESISLELDFLNIFIRFVQILSMNQNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQC7</accession>
    <name>A0A2T4BQC7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_215069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQC7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="217" mass="24151" checksum="639326DAD4C9E1ED" modified="2018-07-18" version="1">MCVYKNYLGPTLVLSMEPDAVGQSRGRGDEEKGGASRGYIGARMATSKTQTSPWERSSVPRQLRTSLPHAEWLRNTRTQELQRERMVPSKRYRSLDLTRKSESVACRTPTLSESPPSLDTQERRGGGTPTLNRVVDGSPRGVALGAKNCLDDSKRESRDTRVPGSAVFQGRFRIGNVMMHGPGRQLQSFRAEQFSNRSMYAGNVDKEAVCHFTPCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQT6</accession>
    <name>A0A2T4BQT6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF654-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1473444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQT6"/>
    <dbReference type="STRING" id="983965.A0A2T4BQT6"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="711" mass="80057" checksum="1F3D7F4C9728CDDD" modified="2018-07-18" version="1">MSTRQLRKLQKQRELEAKTIQEAEGSDDDGDDDEIAPTVAKPRPNLFAALLEEEEEEEEAEDEDEVGADDAEERKEQAPAADAPAPTAASRKHKKKKKKGKKKAATAPTQDAAEHSEDDEIDRAIRELKIEPKPQAASAPGGTPASNGLFKVNLYNLKEVHEMRNLFGRETIESAHAEEVEQRRQGFMPQNVDLETFLRGPPGARKLPEVSRRRNIFIQGREHWPMGSPGGLIMKELGRTYDGTGVEFTYFHTQEYDRTQHMFFAQVQMGDPMRMVHLLIQYPYHVSTLLQVSNVAKQDQNMALASELCERALFSFGRVAPPSFKQHLEQGTARLNCRRPENRQLWLAGYHYIKSLIRKGTYRTALEWAKLLYTLDRTDPYAMRHMIHFLAIRAYEADWLLEFLNQLDPEGSRDDTAYILQSRVLADLQVGDEKKAREHLAEGIQRVPWLYCALFQELNLDAPPSIWGINAESDTSAFWVKLYLYQTKDLWNNPRAIELLKDVAKGLGRVDAKALPQDKLPIDLGAARLAYMDGQTSLLALVPREMLERQPNYEFDPLPPAEKDNIFTADGCRLPWLEERREAVPSSQRLDAMIAHLEEFLARRVPPATHEDEDRLVDELQTGAFLNENREAADGVAGEAVPVSNEDRGMIRALVRMFGFGGGGGAAAVDATGGDDAAGEQYDWEEEEGNGDDSGTADLPGAWPSEEGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQY1</accession>
    <name>A0A2T4BQY1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1343470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQY1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQY1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="527" mass="58121" checksum="A3C1B14A4E882D33" modified="2018-07-18" version="1">MADAELKREVTRPDSVHDLKHGGATAEAIEAIRAEHELTFTEALKLYPKAIAWSGFVSIGVIMLAFDPQLIGNLYSTPQFARDFGHLYQGDWVIQASWQTALSMGNPIGQVVGALFAAYPMDYFGRKLTFAVCVILTAGIVFIQFFSKTLGVLLAGELLAGLVLGMFVVIAPAYASEVCPTALRGHLTSFVNLCFVIGQLLGNGVTAGTSKLNNHWAYKIPFLLQWFWIIVILPGMAFIPESPWWLVRKNRLEDAEKSLRRLASSKVNVQATLAFIMETDRLEQELEAGSTYWDCFKGDNWRRTEISMGVYCTQVLSGIYLINYGTFFFQQAGLPTDRAFDMSVGFLAVGFVGTLVSWALMIKVGRRTLFVTGLAWLVILQFVIGILDCIPGRPSGAIWAESSLMLIWNFFYDISIGPVCFILLGECSATRVRSKTIAAATAAQGILGIVMTVAIPYMINPEQANLQGKLGFFFGGLALLCLIWSYFRVPETMGRTFEELDLLFDKKVPARQFKGYKLEGAVSAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRJ0</accession>
    <name>A0A2T4BRJ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRJ0"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="12543" checksum="8CFD5FF611EC9E45" modified="2018-07-18" version="1">MSGQGRSNVGASNIYEAGDQRNVSQSEAQDAERYNEGQRNSHIANDSKDQRTIANKLAAEERRADPGDDIETVRLKKDPTLPAKVHGNEPSRGAQIDAELARDDEERLKQKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRN8</accession>
    <name>A0A2T4BRN8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1426094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRN8"/>
    <dbReference type="OrthoDB" id="2134400at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="180" mass="20903" checksum="B7A44CED0C95DA32" modified="2018-07-18" version="1">MEEYDYEGRRLPLDYKLIDQDVADLHKAVKSDKGGETLMISIVVQRSDGHLRAVLKEYEHQYRSNFARDALKKSNNLVGEVLAHILNGVINRPVRDALLLQHAITASRKDPLRKELLISRLVRFHWDSFHMQDVKRAYRERYGQDLQDAVREATGGQLGLFCSELCIARMPNEIRRMDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRQ9</accession>
    <name>A0A2T4BRQ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1343092</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BRQ9"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="45"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="320"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="377" mass="42976" checksum="5E8B0A2B6913944C" modified="2018-07-18" version="1">MAATLAEAQPGTAALATGMASTSDPSTDPTLEPLPPTRKFKLSDFKRVRTLGTGTFARVVLVRPANATKPLEEEKNPEVYALKILKKTEVIKLKQIDHVRHERAILADVSGHPFITNLRGSFSDRECLYMLLDYVPGGELFSYLRKYRRFDEPTARFYAAEIVLVLEFLHEQQGGVAYRDLKPENLLLDQDGHIKLVDFGFAKRLGYKDDRPVETYTLCGTPEYLAPEVIHNKGHTTAVDWWALGILIYEFLTGYPPFWHQNPIEIYKQIVEKPVIFPQEPVISDEAQDIIRSFCTIDRSRRLGNISGGAGRVKAHPFFRGVNWDDMLNRRYRGPIIPPIRYPGDDQCFDVYPEDDANSTAYTVDMANKYDCYFKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRR1</accession>
    <name>A0A2T4BRR1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1343017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRR1"/>
    <dbReference type="STRING" id="983965.A0A2T4BRR1"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="193" mass="21095" checksum="FAFA21E0770B0739" modified="2018-07-18" version="1">MPPSPTIPLTPLSQLRISKHLIPAHNLLPNSSLTSKPLLIYHAAFSPSQQQHQQHPNPSPDAIESHLLGVGVVTPQWRYTMYDTTHFHSTAHEVLCVAAGRAKLCFGGELNPGRVEPVVKGGDVIVVPAGVAHRLLEDMDPDPFLMVGSYPNGQNWDMCYGKTDGEYDADSVKALPWFTRDPIYGDQGPVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSJ1</accession>
    <name>A0A2T4BSJ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1310357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSJ1"/>
    <dbReference type="OrthoDB" id="4900266at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="239" mass="25090" checksum="25E2A9D52C944736" modified="2018-07-18" version="1" fragment="single">MNKRKSAVDGEQAQTCKKFKLETLDDAPDVQALDAGTGSSTPSSSAAPKASVSASASGSVSVAAPSSTGTSKAHDAPDAPDAPASERPNKRKAGGDAESSQARKPKKKRLEIDWENFDLEAFEALGRGKSPPKFNFQWKEHVYKPRPPPTPLQQAIRNAPREIHAQFAAYPETDSEVEQKRNGLPSPGSSVDGDAVPQPAANPLGAHYLISIPHPAPQPEGAAGRSEPDSRASVAGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSM4</accession>
    <name>A0A2T4BSM4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1096096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSM4"/>
    <dbReference type="STRING" id="983965.A0A2T4BSM4"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="206" mass="22853" checksum="A08C9A0B7D06478D" modified="2018-07-18" version="1">MFNPRFLIISLGNPLPKYESLHSAGHFVLNGLTKALHQPAFREVTLGRQSCMVSQGPKYTLVQSPTYMNVSGGFVASAWQETVRKYGAESLSLVIVHDELEKDFGVVKMLPWDRSPRGHNGVKSVRGSVSPKKYPESPFARIAVGIGRPEARDAATVSRYVLSKISREHRTALEEEAPWDVAKCLMELEKQWREDVQGSSGTNTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSQ4</accession>
    <name>A0A2T4BSQ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoglycoside 3-N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1394996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSQ4"/>
    <dbReference type="OrthoDB" id="9987540at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="AMINOGLYCOSIDE N3-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104:SF0">
        <property type="entry name" value="SPBETA PROPHAGE-DERIVED AMINOGLYCOSIDE N(3')-ACETYLTRANSFERASE-LIKE PROTEIN YOKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="TTHA0583/YokD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="252" mass="26935" checksum="692A79DE4B8722D9" modified="2018-07-18" version="1">MSGASKYTAIVTPSELTASFKHLFSSIPSADPTVIVHSSLGSIGFIPGFAPSLIQSLLTALGPSGTLVAPTFTGENSDPALWRAPPVPESWWQTIRDSTPAFDPATTICRRVGVVPETLRKWPGAVRSAHPQTSFAAVGPRAEYITAGHAPDCRFGESSPLAKLEAADAWVLLIGVGWDRCTALHLAEYRLQSPGPLVDNSFAINVDGQRQWMTVKDLVPISDDDFEELGADFERDCQVVRAKVGANYGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT36</accession>
    <name>A0A2T4BT36_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1089509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT36"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="195" mass="21468" checksum="CA155D0B591D6FC1" modified="2018-07-18" version="1">MAAGEVNGEGIATKDRRHRLPLRWLNCLGVAAGMRILFVDLLCPWWAHLHHTFSCAMANSLKRRFVVEQCPSQSLSVVVLCLICACRSRWARPTWGLSRNSWAMPPCKGSRKVADAPPRRRTKEKKPGSPHSTGDRSHPHLGAGGFLLQKSGGVLHISGHHAPPPQQAHLHTSGHDVQVQLSIQLQCKAVNQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTA6</accession>
    <name>A0A2T4BTA6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_8071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTA6"/>
    <dbReference type="STRING" id="983965.A0A2T4BTA6"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="70" mass="8164" checksum="D40E20361CB06F27" modified="2018-07-18" version="1">MSLIDAKNKVPEYQRFYQAAYKAHTRLWKIHPRSRWYMGPYLVALWGGFGASIYAASRKVAGHNTWFGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTE9</accession>
    <name>A0A2T4BTE9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1384660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTE9"/>
    <dbReference type="STRING" id="983965.A0A2T4BTE9"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="43"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="246" mass="27244" checksum="AFB9B42770210806" modified="2018-07-18" version="1">MAEKPTPAAAPTQCVGPAFRPVADKPTATVSHEVPFENVCVLPQTPQLIALLSMIRNKDTDRTDFIFYSNRIIRLLVEEGLNHLPVIEKTITTPVGRTYNGLGFQGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEDTAQPKLFYDKLPEDIAKRWVLLLDPMFATGGSATMAVEVLKSRGVPEDRILFLNLIASPEGITTFATKFPRLKVVTAFIDEGLDEKNYIVPGLGDFGDRFYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTH8</accession>
    <name>A0A2T4BTH8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1383672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTH8"/>
    <dbReference type="STRING" id="983965.A0A2T4BTH8"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="479" mass="53579" checksum="E69209F8698CECBF" modified="2018-07-18" version="1">MDGRRSGGQHNGGNHRPRFEFITVSGTNIRGDSETRRRVRSRAQADYRRRNPPPPRNALTVDLDVASWLQTLSRDAALRSDQYAPLPVALQPTPQAGESLQKSPAEYDLTAGRHGASVFSLIPQDQRPRARQLWNHLYAGGCVIFKSMIEIGFLDILHGSASLTQMLSSSAWHRKQASSGDHESSIEYARYSLMATRALRRRIDNPAQRATLETIIAILTFAAFANLISNSQLINVHLDGLTHAINDVGGLPMFSQFPVIWLMVYWIDIRGGYLQDTKPRFPQPYDILMAESKLRITPMPSPNDHSSNCELAEDPAVAHIFDAIQQVAGIIHAEAEAQGDAFWRTVLFPGFHFAPILHDLLSLPRDTGGIGSQFSKRRECFRLAGILYVSELRVKFGMDNTGATSFAYKLLRLLKSRGMFVSWETDNFFLLWALVIGSVSLCVPETLRFEFMELLSEYPYVTGSASLRESLPTVYGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU18</accession>
    <name>A0A2T4BU18_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1465435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BU18"/>
    <dbReference type="OrthoDB" id="4896543at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="437"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="854"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1427" mass="161644" checksum="1B4082370351759B" modified="2018-07-18" version="1">MWRFLKSKTNHTDQSPGDKAGDAIRGRKRDHILSFFDGSSSRSPSRSKSVDGGSQCQPPHNRATSVLAIYALRAASGASEAPGPERSPHAVDASITKETMSHSEVMEMINPLTPKEIPITKGCPRDAVSPQGLWDEAYDKLKSEEPELIKGYERILSNVLQSLQHDQEDSSQVTIKSNSDSRRAQLLDVIKSSQKKIEREGKVKENIGQVLSVISSLNSTIQAAIQAAPQAALPWSIVFMSLEVIRNPMKEFEENIEGLTYVTTRMDWYWNLADSLLGGVESVDNGTASNMQDAMCSRLVELYKELLAFQIKSICSFHRNRGLAILRDMAKWDDWASNLQAVRTLEIRVQGDYTAYTAFEQTNIGRQMRDLLEKLVKRQPKELGPQAKQCLQDLHITDPRLDRDRIMSSKGGLLQASYQWLLEDSTVRQWRQEQQTCLLWIKGDPGKGKTMMLCGLSQELEDAREGPSLLSYFFCQATIPTLNTATAVLRGLLYLLDEYEKVGDRKLFEGVNSWFALIEIFKRILQDQLLQNSCFIVDALDECSDRDRLLDLIVESCAMSTYSLTIDFRSWSLSRTIRASRETSDPSSILQRSNGTFLWAALVIEELKNLETYEDEREVLQFLDKMPSGLPELYDRMIAQIKQLASNMDRADLKGNLARPETLRKLIQMCGSFFTIQNQTIYFSHQSAKDYLVQRGNQIIHYDIYSRSVGALKSQGGLRTNIYALTYPGAKTEEISPPHPDPLEHIQYCCVYWLQHFWDSVEASRTPETGAIEDVYTFLQQHLLHWFEALSLLKSLQTGILLLQRLSALPIVYVSALIFSPRQSEIRQHFQSALSWLKHLPHVDDNWGSCLMTLEGHTNTVTSTAFSDDSRFLASSSNDKTIRVWDLTTGDTIHVFETQRACSVKLSDNCKWLASTSHGQLSVWDIESGNHMYSLALFAHYGETPLDQLVPFSGYRLDIPIWNSTTGKPVEKLPLTLNELYDTTFSLSSDSTYLAQRMGLNQVQITNHLTRNVTHSLQDYIDIVVAIIFSPNANYLALWYSTNRAQIWHITSDQAILILERHEEASSIAFSQDSELLCIGYPNGRVKVWSLEDGTELQLHIGHIQPVTWVAFSKDSKLLATASRDSTIKVWPTISGKQNLLGRFGWPDHGSIALSDDGRLIAAGDKRGVIKIWDRLLHRSLEKFELKSEGRYPPALAFSRDCKLLVILGVADTQNLFIDIRTVGGEPKSRLLVPSSGKRRFEPRAMSITFSPDFAFVAVTYLQFHPLTYDFPISIWDIRAGKRVHDLIPPPDDRFFWPYRLHFTETSLYIQDATSCLKWAEEGSEPEEWCSSTARMRHTGDHPGIGYTYDTNSGCITWNGKDVIWLPTDFRPESPMSANYSTFSTTSFEVLIESPLRGSLLFSFEKPPADLLDWTPWKSSELFKGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUC7</accession>
    <name>A0A2T4BUC7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1363255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUC7"/>
    <dbReference type="STRING" id="983965.A0A2T4BUC7"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="504" mass="54979" checksum="26D58BBFB64C443F" modified="2018-07-18" version="1">MRQRITYFRPQDADWDPNQLAIHDSSVQGPALQALKEHKITLTLPELPSELAGLLRDLEQLHLRWATTASYDTLEPFSSRISPGLHVSYTPAKEDHDPEKLCTALQAFGRLDCSSPDVFINFSDDRQPGSPALFFYNELEKLDGFAKRLGPVVCSGPSATECKKQLHELRDAVSLDMSYDSTSEAVKVQALWPLQKREISVPASPKGRTEVGILGRDAPPGMEAHEIGVSGVLTVIGEQKEPSPALFAFASRHRAAAGSFTSRFQQPTGLHPTLQLRLSGTSAPLHEDDGAECAPYAYFTLPKVIFADRYQLADELFLASKNLTAAKYVSEPVDLEAPAYTTKPWGSNVLLQLAPPKDEAEEWTAEVPLHLRYLKPTPTGKEEAGIPYPAVFWACDGDKDAAFTVSPFDRATLGYDGLFEPGTTFWHVSPQPEADGRLINTISVPVVTEGASQWVGIGTAVAVVLGFAWVVLTLVGGYAKSGHGAVVAKKEDEGKKEDEGKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV42</accession>
    <name>A0A2T4BV42_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1441379</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV42"/>
    <dbReference type="STRING" id="983965.A0A2T4BV42"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="12">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="214"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="461" mass="51998" checksum="E93289A351B064DC" modified="2018-07-18" version="1">MARKTYNIAMVSDFFFPQPGGVESHIYQLSSKLIDRGHKVIIITHAHDDRKGVRYLNNGLKVYHVPFLVIYRQATFPTVFSFFPILRNICIRERIEIVHGHGSLSSLCHEGILHARTMGLRTVFTDHSLFGFADAASILTNKLLKFILSDVDHSICVSHTCKENTVLRASLDPLMVSVIPNAVVGENFRPRDYPAPSEQGGGFRAEPSPRLLGPDDMITIVVISRLFYNKGTDLLTAAIPRILENHPNTRFIIAGSGPKAIDLEQMIETNVLQDRVEMLGPIRHEDVRDVMTRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTQVGGIPEVLPSHMTTFAKPEEDDIVAATGKAITAMRAGKIRTEKFHDEVKKMYSWSNVAMRTERRYYGCGIWAGKLFCLCVVVDYLFFLFLEWWFPRENIDICPDWPRKPPARDKAQDSMKIAMSRSTSRIRVPKLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVA5</accession>
    <name>A0A2T4BVA5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1340781</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVA5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVA5"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="401"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB73225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="741" mass="84214" checksum="E3A1A08C9E7426D9" modified="2018-07-18" version="1">MAADKAALASGADLGDGLRKRQPAFQPVPSFIPAHDTEDTKKLAKKEKSFVEVLAGWESVLAPLIFTAVAIFTRLYKIGLSNIVTWDEAHFGKFGSYYIKHEYYFDVHPPLGKMLVGLSGVLAGYNGSFEFKSGEQYPEDVNYTFMRAFNAAFGIACIPMAYFTAKELKLSRPAVWFVTLMVLCENSYTTISRFILLDSMLLCGTFATTLCWAKFHNQRHNSFEPEWFFWLFMTGLSIGCVCSVKLVGLFVTALVGLYTIEDLWRKYGDRKMPIPVLAAHFSARVVGLIIVPFLIYMLSFALHFAILDHSGPGDAQMSSLFQANLKGTEVGKNSPLEIALGSRATIKNMGYGGGLLHSHVQTYPEGSGQQQVTCYHHKDANNDWFFYPNRHEPDYDPEGEIRFIGDGSVIRLIHAQTGRNLHSHDIDAPITKSHREVSSYGNLTVGDEKDHWKIEVVRDAASRDRSRIRTLTTAFRLKHTVLGCYLRAGNVNLPQWGFKQIEVTCDKQNNPRDTYTHWNVEAHWNDRLPPSDPGVYKSPFIHDFIHLNVAMMTSNNALVPDPDKQDDLASQWWQWPILHVGLRMCSWDDNIVKYFLLGNPFVYWASTASLGAVALVIAWYVVRWQRGFRELSNSEVDQIHYAGIYPVIGWFLHYLPFVIMARVTYVHHYYPALYFAILSLGFLVDWVLRNRAAVVQGVAYGILYSVVIGLYILFMPICWGMTGSSKQYSYLKWFDNWRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVD7</accession>
    <name>A0A2T4BVD7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1078037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVD7"/>
    <dbReference type="STRING" id="983965.A0A2T4BVD7"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="464" mass="50435" checksum="02930E4EFEAED8B0" modified="2018-07-18" version="1">MGVASFFKERSLKANDKRRTKGAELTLRESIFPLALVTVLFFLWGFSYGLLDTLNKHFQNTLHIDQARSSGLQAAYFGAYPLASLGHAAWILRHYGYRAVFIWGLFLYAVGAAIAIPCIKAKSFGGFCASIFIIGNGLGSLETAANPFITVCGPPKYSEIRINISQAFNGIGTVIAPVLGSYVFFNFSDERALQNVQWVYLAIVVFVLLLASLFFLAKIPEITNADMAFQAQEAHGSSDDKPLWKQYRLFHAALAQFCYTGAQVAIASSFINYAVATRPGTSSSLGSKLFAGAQAAFAIGRFTGSGIMRFVKPRWIFLVFISMCIVFICPAITQGNNTGVAMLYVVLFFESVCFPTIVALGMRGLGRHTKRGSGFIVGGVVGGACVPPLTFAAAEHQGSGISMVVPLSFFIVAWSYAFCVNFVPAYRDVVDAFSETDVGTKGHTHDEEIAEKIDNEKPMVTTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX12</accession>
    <name>A0A2T4BX12_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_67491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX12"/>
    <dbReference type="STRING" id="983965.A0A2T4BX12"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="444" mass="50515" checksum="8C335A64CF80106A" modified="2018-07-18" version="1">MHKLNRKAVHPTPLTSMERWALFNQCIDNVPSAEAYLRSWFLGAEIKDIRRDNLRDFLLWGFFDQAGEDVESNGGHSEAEARDLEAFVRRIEDRLGYPLQDGRGPAQCIRLTLDDIEVTYRSLTWYLVIYLVDQAAHMALAWHGFQFYARGLAPTLATFPPRPQEIFTSRRSRAPQLSYWYRPHASSDCNPVVFFHGIGVGLWTYVDFLANIHAAKDVGGGQGIGVIAVEILPVSFRLTSPPLNKAEFLRQMARILEHHHWDRFTVAAHSYGSVQTTHMLHSKSLGHKITSVVLIDPVTVMLHLPDVAYNFTRRKPRGAYEWLLWYFASTDPGVARCLGRHFFWRENIIWKEDFEHADPVYRRKVAVCLAGRDILVNAPSVAQYLTDLGVEGINQARGTADNRTADVEVLMFPHLDHAQIFDTPADCQKVIRLIRSYCGAGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXF3</accession>
    <name>A0A2T4BXF3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXF3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXF3"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="232" mass="25656" checksum="57A02ECD5BEC5770" modified="2018-07-18" version="1">MAQNSLSTPLPEVCKQLTSAQKNGEMCDLVLACNGQTIAVHKLLFCVQSPVMKAACTGPFVEASGTYEIKDCSFETIQRLVEYLYTGNYSNETPGKIEVVHEVAVHVAMFSLADKYLIDGLLTLSETKFRQAVKSEGRISVLLEHVKAVYDLQCDASKALRNIMVDELRQRITRILGRDATQALQSLFDEIPDFAKGVATSYVQQPFMGSCPRCQRDMNSGLSTARNRSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXL7</accession>
    <name>A0A2T4BXL7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXL7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8539" checksum="D6AE713D0BC68EC3" modified="2018-07-18" version="1">MPKQSNSARNNLPLSKVASRHHHPLALARKPMHDLQTTSVWHLSVTPSPAPPLINRIPALSPFNLSTSSPSISRSKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXN2</accession>
    <name>A0A2T4BXN2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_127623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXN2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="19524" checksum="39401B3F43B76FAF" modified="2018-07-18" version="1">MTLLGDRAGPAFTLSFFFEQRLPGTCASYLNVSRALPCRVRGQIHARITGITSDRVQSSNKYKPYPRQRRKRACYTRERSMVVCAPAGQTTTHSGSFDRCLLVMRNDGRRVREQLAREFLWGTVPSQRWEMSNIVGLEMSVLKMEEQADEPNEQAPLWHSTHECTQQVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXU4</accession>
    <name>A0A2T4BXU4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1440376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXU4"/>
    <dbReference type="STRING" id="983965.A0A2T4BXU4"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="270" mass="31826" checksum="94B57C8EB2E2AD7D" modified="2018-07-18" version="1">MSANYWESTQRRHWLFTKEELASMRQKLEEENADLVRMFPLPQPRHMAIYFNQQLLRLGKRLTIRQQAMATAQVYLKRFYSKVEIRRTNPYLVITTAIYLACKMEEAPQHIRLIVTEARQLWQDFIGLDTSKIGECEFFLISEMNSQLIVHQPYRSLLALRPELSLVDEDVQLAKSIINDHYMTDLPFLCPPHIVALIPSMPEVKERVQEARITRVQHFAAWLAESDVDIAAMVDATQEIISFYECFEQYNDKLTKEQINRFVKARNLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY16</accession>
    <name>A0A2T4BY16_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1424031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY16"/>
    <dbReference type="STRING" id="983965.A0A2T4BY16"/>
    <dbReference type="OrthoDB" id="4899351at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="218" mass="24295" checksum="8F52DE239671AD20" modified="2018-07-18" version="1" fragment="single">MAAENEREPATRGRGRGGRGGRAGRGRGGRGASNNAAAGVAKAANNKSGRGGTRRGRAKSFADSRVQAAYERQRDLKATYQTVSYAIKTALQELADRSIDEVERNSNLDDYEATAELQELLDQKLALFERQFQAKTQLAKHTYDASVYVAEQEFQLGYEDLADRFIDGHLNRVRIIGALRSKNLPVDISDDQYEYKVITDHQLDTEFGIYESYKDGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY48</accession>
    <name>A0A2T4BY48_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_20970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY48"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="174" mass="19757" checksum="C9E21C4F20881843" modified="2018-07-18" version="1">MRVGVAAGPPTPVKSPSGRTRANTWSFSKFRRRHMDIQPWYATRLPAKWLSEQMGKTCVAATKWSHRDQHLLLQHANATQMQAVSIKASSSPFDPGYTNGGDWHQTRTSRPRSSRHSAAEETRKLGTCLWRGRTERTLRVGFFFDRVDLQSGCDTGRLRCAQAICNRRDEQLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYK3</accession>
    <name>A0A2T4BYK3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">ATP-dependent metallopeptidase Hfl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1360241</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYK3"/>
    <dbReference type="STRING" id="983965.A0A2T4BYK3"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="449"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="858"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="858"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB74427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="905" mass="99949" checksum="F0615B50CEA90CB1" modified="2018-07-18" version="1">MSRYLRQSGQLARLARFSNSVSLQRTQRLVARSSAISLRALPTPYGIAPRFYSSKPPHPDDSKNSGPDKPNSHNDAGAKPDTDGPESNRVPLPPLPEGWVRLTKEEISQLQSFQQLLPEGQRQTLKDILVGIQHTGVPAEVRELLHKMRQGPGNLSIMDKGRLMRCVFITAERVAEWEIEQQQQGKRGMFDQNNPEMNEHKDGEKGEKGEKGEDAGRSHKASSESQASQQGSGGKSPKPERNGWMDALQTGLVLGITLWAIESFSRPFSEKEITWQELRKAFLDKGLVQKLVVVNGSQVRVELHPDAVQGATDGSGARRTYVFSIGSVESFEKKLEEAQDQLGIPPSERIPVSYESGGSTLGNLVLAFGPTLLFIGLILWTQRSMGGRAGGAGGMFNFGKSKAKKFNAESAVKVKFSDVAGLEEAKTEIMEFVSFLKQPEKFEKLGAKIPRGAILAGPPGTGKTLLAKATAGESGVPFFSVSGSEFVEMFVGVGPSRVRDLFAEGRKNAPCIIFIDEIDAIGRARMESGRGFGGNDEREATLNQILTEMDGFNTREQVVVLAGTNRADILDKALMRPGRFDRHIYIDRPTMKGRQEIFQVYLKKIVTKEDQEHLVGRLATLTPGFSGADIANVVNEAALIAARENADDVKMTHFERAIERVIGGLERKSLVLRPEEKKTVAYHEAGHAICGWFLKHADPLLKVSIIPRGQGALGYAQYLPQDAYLMSTNQLMDRMAMTMGGRVSEELHFPTVTTGASDDFKKVSQMARSMVTQWGMSEKVGPVHFDNDPNRMVKPFAEATAQQIDDEVHRIVEEAYARCRNLLVEKKKEVGLIAEELLKKEVLSRDDMVRILGKRPFDDNEDFEKFFGGKEESAPPPFPTETDTPRDDPPAPAPAFRDLPDDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYK6</accession>
    <name>A0A2T4BYK6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1440562</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYK6"/>
    <dbReference type="STRING" id="983965.A0A2T4BYK6"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="351"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="534"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB74410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="633" mass="70287" checksum="DEC57319068D8D39" modified="2018-07-18" version="1">MADGDSLADNYQVLEELGRGSFGVVYKGIDKVTGETVAIKHIDLESSDDDIQDIQAEIAVLSTCASQYVTQYKGSFLRGHKLWIIMEYLGGGSCLDLLKPGTFSEAHIAIICRELLYGIQYLHSEGKIHRDIKAANVLLSDAGKVKLADFGVAAQLTNIKSQRNTFVGTPFWMAPEVIQQDGYSFKADIWSLGITAMEMANGEPPLCHIHPMKVLFQIPKNPPPRLEGHFSKDFRDFVAQCLTKECARRPTAKELLRHRFIRSAGKVEALQELIMHRQMWDANRNRQKHAMYYQETVQPISAKNNDVEAWVFDTVKSAAPPKRPTVKHRKTSSVLSTAEEAVRKMDINDRCLSPASPATSTVRKATVRRNPSIIQVPSPYANGSPRGPNIAPKRPLQPDTSFGNSSGSTMRLYRGAAADSPSGLRESRSATPDDDVFVDENATRPSPAATPCEPHNKEGVLGRRLWSKALEPTLASLHTQTFTKRKQEALAKVSEAFAALDAVDPEGAYYLMHNLVLAVSQDDKLDAALLRHRDQKVPDDGTPQGTVLVKNSTPSTSPTKMMPGSANPRYKSQRRRQLESPLSRESLRGQDKPAIEEKYPGREAQPGMEHCKQLSDVLYNRWADGLRIRWPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ13</accession>
    <name>A0A2T4BZ13_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1338274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ13"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ13"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="93"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="332" mass="35756" checksum="8C4AA1BBC180A21E" modified="2018-07-18" version="1">MPITILNPQPSTPAPRRPRAMDIDMDVASDSDSDSEMGGAAILTPGTVITSNPQWMRGHGTYVPPNTTNITSSLAGTLTRTNKLLSVRPLRARYNPEIGDLVVGRIVEVQAKRWRVDVAAAQLAILQISAINLPGGILRKRTETDELQIRSFFAEGDLLVAEVQQLHQDGAASLHTRSLKYGKLRNGVFVAVGGTGGGGGVVRSKRQLWTMETANGGGKIDVLLGVNGYIWISKHAESDVAAEAAGINRMEESVSSQIYSSQNNHIDVPTMREIARCRSVILALVENGVKVDEDTVTRGYLEAVEFGRESADDDIYLGGERGKRLAAALSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ84</accession>
    <name>A0A2T4BZ84_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1336376</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ84"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ84"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015611135" evidence="17">
        <location>
            <begin position="19"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="477"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="654"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="771"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB74621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="863" mass="94805" checksum="CD0F4E49F7FEEECD" modified="2018-07-18" version="1">MRILSILGLAGLAALSSAARIARDYDKNDYYVLHLDRSVQPADVASRLGLTHEGQLGELTDHHVFRAEKHERDIVKDEVRERKRRKRDLGGFDVLDGVLLTTKQKARNHLQKRIIPPRPPSDLLPRLPQSPDASAVQLQESVMAELEIADPIFKEQWHLLNTVQVGHDVNVTGLWLEGITGKNATVAMVDDGLDMYSRDLKDNYFAEGSWDFNDNDPEPKPELSDDRHGTRCAGEISAVRNDACGLGVAYDSKIAGIRILSSAISDADEAEAMIYKYQDNQIYSCSWGPPDDGRSMEAPDVLIRRAMLKGVQEGRGGLGSIYVFASGNGAASGDNCNFDGYTNSIYSITVGAVDRAGQHPYYSEHCSALLVVTYSSGGGDGIHTTDVGENSCYGMHGGTSAAAPLAAGIFALVMQVRPDLTWRDLQYLAMDTAVKLDDQADAEWQTTAAGRPFSHTFGYGKIDSYSLVEKAKTWQKVKPQAWFFSPWLHIKKEIPQGNDGLVVSFDVTADMLRNANLARLEHVTVTMNVEHTRRGDLSVDLISPDSVISHIAVTRKSDDFKGGYDDWTFMSVAHWGETGVGKWTLVVRDTEVNKEKGKFIDWHLKLWGESIDASQAQILPMPSEDDDADHDLVISTVSGAASTKSLSIASSSKTAAATIPTDHPVRPTKPGAKPTETKKPQEGTVDVKPTDTEHEAVPGTPTAPASSTTSASSWVSWLPTFGTKAKIWIYGAMGLIAAFCCGLGVYLWIARRRRLRNNPRNNYEFELLDEEETEGLNSAEKGPGGAGKKSRRTRGGELYDAFAGGSDDDDEFDEYRDRAADRLAGHNPDDDDLGEHPGRYVVGEEEESDDDDDDEAEKRRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZR2</accession>
    <name>A0A2T4BZR2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AhpC-TSA-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1337056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZR2"/>
    <dbReference type="STRING" id="983965.A0A2T4BZR2"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000404">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41415" checksum="45D01383B100CE77" modified="2018-07-18" version="1">MDVSAPPHTFTGILDEQQQHQTTQHSSNSNANGSSNSNRNSHAAAAGTTHDTRSDRASSSYRRSKPPSLEIDKTRPQDFDGELQTNNELPSAEVQKMIEDYIVLDKDGKSRTFKSLYTGSNVARRVLVIFIRHFFCGNCQEYLRTLSEVITPDSLLRLPISTFITVVGCGDPKLIDMYAKETGCPFPIYTDPTRQLFDALGMVKTLTMGAKPAYTKKSTSKGIFDSIVQGLRQVPKGLALKSGDHRQVGGEFLFEPLHISTPLSTPREEQHPQFGTLDKPEAGKGKVDEERAEEKKITWCHRMKTTRDHAEMPELLEVLGLDGIIEKPAVMDDKKWEEMRRERKGTGATMAPEMKRLSQAARASVEQAHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C034</accession>
    <name>A0A2T4C034_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1336619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C034"/>
    <dbReference type="STRING" id="983965.A0A2T4C034"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="13"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="435" mass="48944" checksum="B3A430861F6BEEED" modified="2018-07-18" version="1">MAHDITEGQAKVLTTIERTNAIISMVACAFTILTFCFSKYFSKSINRLVFYASFGNLLSDIAIIMSRDFINNPDSAGCQIQAFIIQVFLSSDVLWTLAMAINVHLTLYYKYEARDVRKLEPIYLVCCYGIPLIPGFALLFAKGHHGVRIFGPAIAYCWISSDWALLRILVFYAPIWVVIITIFGIYIRAGRTIYKVRKQVYFFQSSDLDPISIDEVTSPIQSSDEIHTVGPMSDPERTTIDYILSQPDGHAAGSTSESPTTRPPPVHLTSNKSNQSNNSDGTHPPFYFYSDIPHRGSDPPQPPRNASHPSHHSAASRALRALRRRNHERDNAAWSYTKCALLFFGAMLITWIPSSANRLYSLTHNNSISIPLQFVSAFVIPLQGFWNCVVYVTTSWVACKNLFRDMWLATVAGTNDFAERIRSRPDSEVEETRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0T0</accession>
    <name>A0A2T4C0T0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1402730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0T0"/>
    <dbReference type="STRING" id="983965.A0A2T4C0T0"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="299" mass="31682" checksum="64A06CD01BFD10B9" modified="2018-07-18" version="1">MAAKRTVLISGCSDGSLGSHLALAFHRNGWRVFASARNPSKLEQARASGLEVVQLDTTDDASVAACVARVSELTGGSLDALVNNAGAGYSMPVLDLDLAQTRQLFELNVFSLLAVTRAFFPLLVRSRAPGGGLVVNNTSCMALPHASMPFSGAYNASKAAAASFSEVLRLELAPFGVRVTNLVTGSVRSTFHANAPRVSLPPTSIYNVAKEAVERWMSGAEATATGADPVQWAEGVVKDLSREKPPLWVWRGKHAMAARIGSFLPVGALDGVYKSRTGLDEVSRKLKEQGGLESIFKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1D2</accession>
    <name>A0A2T4C1D2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1D2"/>
    <dbReference type="STRING" id="983965.A0A2T4C1D2"/>
    <dbReference type="OrthoDB" id="5409998at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="453" mass="47880" checksum="B7F722995AEDE6DE" modified="2018-07-18" version="1">MNVFVPLNPQRPPAPATAASPLGGTFRKPSVRIRPRPPTSHAQPRASQQSQSHRRLSSRNPDSPLPPLPDTSAAPVASAPALSPFSSLFTRSRIAGEMAASPSISGPLDALQSIINDVLVQTGKALRASRRDSQGNLTYAYGPTQAKLPDTIEQFHMTLHDLETEILSAKSVLLRDYNELQEKKRQILLRPSFQTGDGQTKRPPTVEMATPPEPVFKDETMAEDTGVKPMAPFPNMSIDLAEPEPMEISVKDLNGQQPQQQQPPPPGGMNGLNATASPAIASQPPNVDPKPTADMHTGPSGPAMPPAMPETSGMNFTDMEFTLAAPPGSEAAGQPNTTKEPSFDMATFAPPEGGDDLLNLNHLLPADANNASGAAPRPQTKADGGAAPVNTDFFGPGSGAADGMDFDFSLGGSGDDTFDDLMNNRDSTFELMDAGGDFDTAFFGLDKADENPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2E6</accession>
    <name>A0A2T4C2E6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_54459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2E6"/>
    <dbReference type="STRING" id="983965.A0A2T4C2E6"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="53316" checksum="C990198DBED88419" modified="2018-07-18" version="1">MPSAFQRYLPFAASTTPTQAATYLLGISLFSISFLVFLNSSVSFVITDLIGQKKNVGDVVGTLGFADEIVALIACPAWGLVSDRLGVRWVAAIGYLIVGLSLVVFVQASNVYPQLLLARILFALGASATATMVTAILPSLTDEDEELRNSALERARAARNSLSSARLSAAYSVESEATITPEMYSRSLSSEGRPISAGVDPQGRSGKSSVLAGYVGLFTGCGALLALSCFLPLPAKFGEIENVTPGEAVSYSYYVVGAVALLVAVFVFFGLRDVQGEEGKGWRLLLGFKGSSSDGYAYSGRTQNKVIPYLHLMMDSILLGFTDSRIALGYLGGFVARASTVAISLFVPLYINTFFIGNGFCQGSPNDPSPELKKECRQAYVLSSILTGVAQLMGLLCAPIPRNARRQHFLAPDEDESGESEPLIRIATEEEFVSRLRLKGSIAGVYSLCGGAAILLLTKLGGLLFDKVSTGTPFYMMAGFNAVLLLATLFVDASQTFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Y9</accession>
    <name>A0A2T4C2Y9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1264681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Y9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18521" checksum="814D42BBAAC82B1B" modified="2018-07-18" version="1">MYCCLSHSYSRGARSSRYCKIRRVGEPLFVVQFKRQFVMAASGNEGAYGRHLMVVGSRDNAAVVLMGRARSWRGAWERVIQRLWMLIRSLVAGPNNFRGKRAEGLPRGFGHRRCHGMEGWKSFLFDALSNSWGGPGESLSHHQGGVYFSPWLIVREDRDDDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C312</accession>
    <name>A0A2T4C312_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1431549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C312"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="464"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="721" mass="79881" checksum="46A9AB6BAA86C156" modified="2018-07-18" version="1">MSSNAMWTRDEAFDESDLSFIKRLAAIGDSYSAGIGAGNRLGTFLNALNPHSDWACSRYDNAYPYLINEDSRLGSPVNRKFQFESCSGAVTADVVKKQIPRIDSGQQVILLSAGGNDAELVAILNQCIFQWAVWNEDQVSVAKSAALDKKFDWAGDYDWDALGRGCDAQLDRSQQIIDSRQFSDSLDSLLAAAKQKLATDYARFFAEGMSPDCDRVSWSTWIYKTYNVFQKEQYLTAVHRERMNALVDAMNFNLAEAVKRAGPQVMFVDYDQYVGRWGGRYCEAGVDESTSQSNTRTGLMFYELNTWDPLGATPWRRSSADPLNGTFHGEQEAFAQITLLLDPHADFAAAEANNPFRLAVQPNQTRPAQELELPEVQIPNLLPDGYGRVFHPQILLHHVIANLVVYHMVERNAALNGQPDVPEVRRVDTCPLPLSGIGRDVLHYKNTQPGRRIKGGIDLKILGVGDSITAGFLSDLDGGDGNGYQLQLRNDLSENKVVFAGTETGGGSMSDRHFAAWSGEPIDYIADHLGPSLEQRPNIILLHAGTVDMSPDSALPTDGNDPWVTVGHLSMLVDKMIEKCSDAVILVAVIANTCSVGQSGRTEQYQAMIPEMVQQRRDRFQRILAVDFTSFPTSLLRDCIHPINEGYKKFGDYWYDFITQIPREWINRPAGEVTDGEDLPSVECVKDADCVEDLNCPAGFHRGCGLVWLIPSGLSCMCLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C319</accession>
    <name>A0A2T4C319_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_66549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C319"/>
    <dbReference type="STRING" id="983965.A0A2T4C319"/>
    <dbReference type="OrthoDB" id="4898213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="384" mass="42430" checksum="37FE2D0272F6F5B1" modified="2018-07-18" version="1">MPISPGAALKAQWATPGDIFSVLLILGGDVVQLALVSLAGGYITPLAFSFGSIAYAISAVLSAIGENRLIACSPEVSLQVINVQSGYRRTNQSWVIGRLFKTYSFWMPKDVAQKASNIHQAAPALCVAIYKWSESRPFGDSLHDWVWWSGVAVTAVQLGISAIPFGQERDWSIFLITAAGNALSYASGSLPQWRQEKWYAPRLNSEKQVALTLGNGSRHVMIVHGRKGDVDLEALAAGWTPVVWSTRPFTLVLAILWLALLVTSTGIKTNTWYLLAVGGLGMLQNLLAAGAPRYPPSLGLPIELVKTSSVYGKVPAVFGEAKVMWTLMELEDKYKHHGQSLVEEFFPGKLNEWEEKWWAEPDSLIRRELLEEVKRQHQRSREDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C354</accession>
    <name>A0A2T4C354_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C354"/>
    <dbReference type="STRING" id="983965.A0A2T4C354"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43336" checksum="C65F7814EC9C99A3" modified="2018-07-18" version="1">MPPSQCTPTRVSPRRDAGAEADAAPTASELRHARRRVQNRLNQRAHRSRARDKRIDSSTQPYRVHRWRIDDGRDDMPDIIKRTRSNTRSNNPDYGSIPGAHMKENKSAHQHQPGASTHSEQQHQEANIEAHQHYAPLASVSVSVPDRAASSPGLSLSYCLLSDHLLHLIHFNVLRGLSYNKKVIKPEALLECSRGSASAQLRRVLPHLPATTASLSPLCLPESLAPTRLQLSCPHSNWIDVFPFPRMRDNLIRREGCFSHAEFLTDLLGNLISCMTAPPPRTGRGSRLLRPRARITESHRRGEDDENCADGENEYMDDGDGGDDAPADRRGFILWGEPFHKDSWEVTPGFLRKWSWAVEGCGELIESSNRWRTARGETPLRMMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C398</accession>
    <name>A0A2T4C398_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1401495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C398"/>
    <dbReference type="STRING" id="983965.A0A2T4C398"/>
    <dbReference type="OrthoDB" id="5428038at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="687" mass="77498" checksum="88C37521A8C98FD3" modified="2018-07-18" version="1">MSVRSAAQCPPRGIVSPSSAVWITDAMLRQAIDRYHRQFSAAAQCRRISSHSGPLESRRRQLGKRNMTGIMPSSATYPPLWHFDVAWVPSECKWEPPSTVEERRRKKQSISPSALFESLISWLEKSDADKPFIAPPPADPIVSSTSTGEATAAAPAEAIATEYVHQDVPTRAKVPRELSVLRRSISRLDVVDVKAIDDLLKPFQRKYFRKMETANLSVEGLGLLMEPLDQAARDKISDPSMVELLIARVRRSLLTGLEIAQNRVPDSVVLPDLWTTFASVVCSSGSGYQNIRLFRKVMSLMPAYIRAQIQMDEISTLAASFVLAQASNSNLVSRWSRAASQFGEALSKLSPLQLQILDLEVNALFLQREQDVEESRRLRFAWLMAKAYNSSATNEEFVQSYRELIASRDIGLVSAQLWQVTVARLKSAEVIDTIPHFDLTRTKYSSLSQRWAALFSAIHDLPNANDVLTDLYGFFKDIHRTDALIQAISYLPISPMSIDTARTIATACDDHKLALQLYETIRARLGPDARIESWGWEAWVPYLERIIKDPEITRPVHWELLDLPRLATPPDADPEEVAREVQAKMALVDRIGQWYMEAPHLNDRQLLRRLQRCVDVQRALAEAVSPQVLARVAEVVTRDLQGGDWGRTTRLRWLLGMVAQTHGEEQAGDVSRTLEGWRRMVDRYKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3E4</accession>
    <name>A0A2T4C3E4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1401544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3E4"/>
    <dbReference type="STRING" id="983965.A0A2T4C3E4"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="200" mass="22176" checksum="335BFC549EE4FAB0" modified="2018-07-18" version="1">MSAKPTTKQFGKSTREVPASADKAKKWYPADDDSEPKKVRKAVRSWAPRKTLQPGTVLILLAGRFRGKRVVLLKTLDQGVLLVTGPFKINGVPLRRVNSRYVIATSYKVDISGLDAAKIEEISQPKYFTAEKAKEKASAEAFFKQGEKPQKKEINSSRAADQKAVDKALIASIKKVDLLASYLASTFSLRKGDKPHEMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3L8</accession>
    <name>A0A2T4C3L8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1332879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3L8"/>
    <dbReference type="STRING" id="983965.A0A2T4C3L8"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="465" mass="52073" checksum="034A735B8B5047C9" modified="2018-07-18" version="1">MSYQGYGPPYGRKYRLRDGQYPPQQGQYPPPQGQYPPQHGQYPPPQGQYPPPQGQFAPPQGAQYGQYPPAQPPQGGYYQSPPPQGQYPPQQAPYGQPSPQPYGAPPQHQQPYGAPAPSPYGAPPPQPVGQYAAPPPAPHAQVPPTPPSPGYGPPQLIQYDATADADALRRAMKGFGTDEKALVNILARKDPLQIEVIRTTYERRHKRSLIDDIEKETRSWFEYGLVQLARGPLMSDVHNLYKAMSGPGTKEILLNDILLSRSNADLKAIKSAYQQTFRRSLESDVKGELSLKTERHFLIVLSANRAEDMAPVNPQQVEEDVMNLYRSTEGKMGTDEILVCSILSTRNDNQIRAIAHLYKQKFNRDLDSVISSEFSGHMKDALLFQLRHAVDRYMHAAQLLEDSMAGLGTKDHLLVSRVVRFHWDRNELANIKGAYQQRYRKSLSSRIRSETSGDYQMLMVACVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4C2</accession>
    <name>A0A2T4C4C2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1401858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4C2"/>
    <dbReference type="STRING" id="983965.A0A2T4C4C2"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12183">
        <property type="entry name" value="LDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058205">
        <property type="entry name" value="D-LDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026:SF1">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="113"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="346" mass="37400" checksum="55A1FF67D1AC0C88" modified="2018-07-18" version="1">MKLAVFSTKPYDKRYIEAARATSSVPIDVVYHEFPLEQDTVILARGADAICVFVNDSLTAPVVEALAGEGVRAILLRCAGFNHVDLVAAEKAGMMVANVPSYSPEAVAEFAVALIQTLNRNTHRAYNRAREGNFALNGLMGRTLFGKTVGIIGTGKIGIATAKIMKGFGCKVVAFDPYPSKAFEGIGEYEVLDEVLAESDVISLHCPLMDSTRMIINDEALAKMKAGALLINTSRGGLVDTKAVIRALKTQHLGGVALDVYEGEGSLFYDDHSGEIIHDDVLMRLMTFHNAIVTGHQAFFTEEALKEIAECTLRNVGEFLSTGTCTNSLTKDLRLIRSESLPVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4M2</accession>
    <name>A0A2T4C4M2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1422572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4M2"/>
    <dbReference type="STRING" id="983965.A0A2T4C4M2"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="19993" checksum="24939628A4183C03" modified="2018-07-18" version="1">MAASILRTFFSPARQTLTAFSTPSSISSRLQAQQPSSPSSLFSSPTALLRAFSTTPAPQATLNQVLRGIRKGKRARHAVSPALSNTHCPALKGVCLRVGVVRPKKPNSGERKTARVKLSSGAVVTAYIPGEGHNIQQHSVVLVRGGRAQDCPGVRYHLVRGALDLGGVASRTTSRSKYGTKKPKKATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4U2</accession>
    <name>A0A2T4C4U2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_355646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4U2"/>
    <dbReference type="STRING" id="983965.A0A2T4C4U2"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="186"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="267" mass="29241" checksum="2DCBA7820305CB83" modified="2018-07-18" version="1">MSLPLSSDENQRYTAIIDDILATADLLTISRKKIRQGLEAALGGKDLSEQKDAIKRLIEERFDAVSGADAGDAAPSVTPEAADNKRSATTETPEHDGLSASPEPAKKKVKRSSSTEDADARLAAQLQEMENSLAKGRTTRGRGDKARLVKKKKAPRKKSAKKVGDDDDSEVDASGDSAPKRKAGGGFQKPFLLSPTLSELCGETQLSRPQVVKKLWEHIKANDLQDPKDKRQILCDEKMQAVFKQTRVDMFRMNKEIGSHLYPVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5A2</accession>
    <name>A0A2T4C5A2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1331653</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5A2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5A2"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="473"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="643"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="687" mass="75770" checksum="9403700DC9B65E4A" modified="2018-07-18" version="1">MASPIPDSPVSPRSGSNNQAYPPRTTASTPNDRRPDSVVSSHMTDIASEDEADGNASTSAPRTHHTRESGSAIRPETAKTGASSKAWGGARKSLGVGKRGSGTSTTSSALGLSSSSVTSRSHVPSLTSNAFFHPMSSQKLQAQRAVAARPPATAQPPAAPQPQFGDLPDNATDFDGSVIHDFAPSPVAHHAPPVQFQHVMYSEDQRQLPSRGTDFTEHDTFDQATETTTSPTGHYAGGSLSESVRPLRKVSGPEKTPPHLDLSRGSHLRDLRSFPSPMLKTPRSFRSTFLPGASDQGQAQSSENRNAAGVEKLASTAASSPRLNPVDSQVRPKTESTAVKRKTRRRRNYEYFEGNTMFLFGGRWQNTRQRPINVATGLFVVLPCVLFFVFEAPFLWHHISPAVPIIFAYLAYICFSSFLHASISDPGILPRNLHQFPPLAPHEDPLRVDPPTNDWTLIKSAEPTAAAMEFPVKHCRTCNIWRPPRAHHCRLCDNCIETHDHHCVWLNNCVGKRNYRYFFTFVSSATVLSLYLIGVSLAQLIVYANQHNISFGKSVNHFRVSLALVILGIFCFLYPAALMGYHIFLMARGETTREFMNSHKFTKSERYRPFDQASIWRNILAVLCRPRTPSYYQFKKSYENGDQRLGLHRHQRPAPDSRGHEMSAVKPSSQGGFQGPVALRGSSHGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6D1</accession>
    <name>A0A2T4C6D1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1332042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6D1"/>
    <dbReference type="STRING" id="983965.A0A2T4C6D1"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26900" checksum="EEBD908438804050" modified="2018-07-18" version="1">MLISINYRAASLRPGSMMLSRIAAPAQARAFSTSFAMRFNASRPLFDGNDRINPLVGNFAPPAPAPKPAAAAPPPKPQSEAPASTADFVPPPPPPPPAADSASPSASSEKSSSSSSTQFPYTAADSSAPFNFDIAEIVAARSAAYGQSLNVGDPLLRPKVRTEAVSGRTVFIRDRLSPTSAPTPAVAIRVLERMCREQKVRNKYHSQKFHERKGLKKKRLRSQRWRARFKTGFKAAVSRVMELKKQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6D2</accession>
    <name>A0A2T4C6D2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1376685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6D2"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="399" mass="43834" checksum="B807C6D7CD93A51C" modified="2018-07-18" version="1">MALYSSAPPERPFSDAKPTLLVAWWITLFCTCLILLRLSGRYIRVEKLFLEDKITALALLPLYLRMACTHVVLLYGTNNIELAGLELSPVEVHQRIIASKVVLAGRLFHAATLWTLKFTTLEFLNRLAGASSKKIYKILINILRTLLAASFLAVVVSDLAECRPISHYWQILPDPGPQCRQGVAQLLTMGISSAVLDAMLIVFPIPIIMSTRIPTRRKVLLSMLFCFGFLTVGITIYRIPETIKEHGDQIVRSMWASVELLAATAVANLVALGSFLRDSGARKIKFRPNYHSSGTTSRPQQGQGTTASVWDQAESEHRARSDINRWEDAKQADTAANSLSNGGARPQSSSGSAVSPTQSHDSLIQADRGSTKAAAILSLETPRSPERVVPAGMTSLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6H6</accession>
    <name>A0A2T4C6H6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_311709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6H6"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="377"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="980" mass="110484" checksum="6E39894B3BE53940" modified="2018-07-18" version="1" fragment="single">MSLDVQRSATVRRSTTVHRSGTRKGPNPAVNATASKKQKGYEVVQQGIKELCPLDKANVVPDLDIVFVPGLGANPEDSWKSSKTDFNWTTHTDGLRRDFPKARLLLYMYDSAWTGQLKVKQFMGNIAMGLLVGLRSKREKCQRRPIVFIGHSMGGLVVAKAITLADSRRDLFPIMFEATTACIFFGTPFGGAPVASVAAMYAHFAEKVDVAFSSKLLELMKPGDEELRQLTHDFMRLAGKISPKIELFCFWEEHPTDFSKMAGLPSLFGLTRSLIPKQYAEFVSRDSATLPGVEELGLACNHRDLVKFDGPKDDRWTQMVRDPVKRIIHGAQLAVRNRLNSVRDIDRAMISGIMDALDGAQVQKKRKALSQSFSPSSWIPQEAEYLEWLGSSGEPNEAQASHTVDCLYVRGPEGRGKTNATMAALDGIEKLMRDNEENDSGQGPILLVYFFCDTTAEYSTAEDVLKSAIRQLINQQETLAPYAKIFTKKKGKDDASRSQQAQITVENMWQSIQDMLADEFIGSRVYFVINNLHALPAESDSTIKLMKFIAGELEGIRSTDSKRVATRWFITSRESHNIDNVLKTDRVRVIDLEDSRYENQVQLELRKHAKKMISAIGQQKQYNKALAYFASSLVGKRAQNTQWIDITCIQLGELSDTESDLGVRRILENMPQDLKTLLDHSWRQIFQLNEAHVEKIREMLRALVLTYEDPTESELGLLAGLSSGDQERGELRKLIEQCKPLLFLKRTGKPDSVVCFVNIIVKTHLWENAKELLGLSKEEIKWQHGVLALRCFSHIKDALDFPMPDPVPEETETAELPETTEGEDAGEDDATEHEDEEAGAIDDTEEEVDNDEEYSESEETYEEDGEEEEGEADPEVEMVKDKALAYTVKHWLHHASKATLEIAEDLSLEDDFWNPDSTIRRRWMIEYARMTSTFDDFDYKTLNGLHVAASIGFRQLVAALIRNGHEAEIKERDSLVNTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Q0</accession>
    <name>A0A2T4C6Q0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1437830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Q0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Q0"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000091">
        <property type="entry name" value="Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="601"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="812" mass="91699" checksum="764E0FFE4168E69A" modified="2018-07-18" version="1">MADVQSIRAFGVARSTIKGKPLSDEEIKQYNDYFKASCYLALGMIYLRENPLLREPLKKEHLKARLLGHFGSAPGQIFTYMHFNRLIKKYDLDAYFVSGPGHGAPAVLSQSYLEGVYSEVYPDKSQDVQGLQRFFKYFSFPGGVGSHATPETPGSIHEGGELGYSLSHAFGSVYDYPNLIALTMVGDGEAETGPLATAWHSNKFLNPITDGAVLPVLHLNGYKINNPTILARVSHEELKALFHGYGWTPYFVEGDDLDSMHQAMAATLEHCVNEIQRYQKEARETGKATRPLWPMIVLRTPKGWTAPRKVDGNYLGGFWRAHQVPITDPSTNPEHLKLLEEWMRGYEPDRLFDESGKPIASLTALPPTGNRRMSANPVTNGGILRKPLNMPDFKKYGVAVEHPGAVMDASMQKLGVFLRDVVAANPHNFRLFGPDETESNKLSAVYQAGKKVWMGEYFEEDENGGNLAPAGRVMEMLSEHTCEGWLEGYILSGRHGLLNSYEPFIHIIDSMVNQHCKWLEKCFEVEWRVRVASLNILLTSVVWRQDHNGFTHQDPGFLDVVANKSPEVVRIYLPPDGNCLLSVMDHCLRSSNYVNVVVSDKQEHLQYLDMDAAVAHCTKGIGIWPRFCTDIGQEPDLIMASCGDISTHETLAAIDLLLQHFPELKIRYVNVVDLFKLIHPSEHPHGLSDNEWISLFTADTPIIFNFHSYPWMVHRLTYKRPGSQNIHVRGYKEKGNIDTPLELAIRNQTDRFSLAIDAIDRMPHLHNKGAAARQAMLNAQIEARNEAFERGMDPEYLTKWTWKRDGLWNKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Q1</accession>
    <name>A0A2T4C6Q1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1437795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Q1"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Q1"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="4">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="240" mass="26170" checksum="06EA45A65B596DEB" modified="2018-07-18" version="1">MAHHGFGGVLDTPRSNAGDATYLNQMPDFADITQEASFIAPDKDDDLLQQLRNGRSNGTSFKTPRRRTSLADRRNLPSNIGGGEFTPLLKSATVNSSRRTGKGAAVTSTPAALNRIDEDEMTPLPRMDFSALSARHADFLDNELPQIEASSASSTPMGLPPRRDVDKGPLQDGNQLSLREQEHVIDKIEKENFGLKLKIHFLEEALKKAGPGYSEAALKENTELKVDKPSVTSRASANRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6W0</accession>
    <name>A0A2T4C6W0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M440DRAFT_18478</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Vacuole membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C6W0"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000446">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000487">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="HEAT" evidence="18">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="21">
        <location>
            <begin position="1243"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="2021"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="22">
        <location>
            <begin position="2400"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2349"/>
            <end position="2376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PTB77317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2432" mass="275810" checksum="0337F702410E0BC3" modified="2018-07-18" version="1">MAQAQQVALERLDYITRGLRSRANDEVRKRAAIQLRELVTVCHRDLSPEQFLTFYNNVNNKITQLITHGSDSAERLGGIYALDALVDFEGVDVAAKYTRFTQNLKTILRGKDTMPMRHAAIALGKLCRPGGAMISELVDSEVNTALEWLQNDRVEERRYSAVLVLRELARNAPTLMYQYIPTIFDWIWVGLRDQRQLIRETSAETVSACFRIIRERDQEMKQIWMSKIYNEARQGLKVNTVESIHASLLVLKELLEQGGMFMQEHYQEACEIVFKHKDHRDPVTRKTVVLLIPDLASYSPADFAQSWLHKFMVYLSGMLKKDKERNDAFLAIGNIANSVKSAIAPYLDGVLIYVREGLSVQSRKRGSVDPVFDCISRLAVAVGQTLSKYMEALLDPIFACDLTPKLTQALVDMAFYIPPVKPIIQERLLDMLSIVLCGEPFKPLGAPQPNTLTSVPTITKDAKDPQAYENRKTEIKLALNTLGSFDFSGHVLNEFVRDVAIKYVEDEDPEIREAAALTCCQLYVRDPIVNQTSYHALQVVGDVIEKLLTVGISDPEPNIRRTVLAALDERFDRHLAKAENIRILFFALNDEVFSIREVAISIIGRLARYNPAYVIPSLRKTLIQMLTELEFSDVARNKEESAKLLSLLVQNAQSLIKPYVEPMISVLLPKASDPSPTVAATILKAIGELATVGGEDMLPYKDRLMPLIIDALQDQSSNIKREAALHSLGQLASNSGYVIQPYLEYPQLLEILQAIIRTEDQRGPLRQETIKLMGILGALDPYKHQVEDKSPDSQRRSESNQLTDISLMMTGLTPSNKEYYPTVVINALLQILKDHSLAQHHAAVIEAIMNIFRTLGLECVSFLDRIVPAFLLVIRSCPPTRLESYFNQLATLVSIVRQHIRNYLPEIVDILQEYWHKSASLQTTILSLVEAISRSLEGEFKIYLASLLPLMLGVLDKDVSTKRTPSEKVLHAFLVFGASAEEYMHLIIPVIVRTFEKQGQPTFIRKQAIDTIGKISRQVNLNDFAAKIIHPLTRVLDMGEPTLRLAALDTLCALVQQLGRDYIHFMGTVNKVINQHQIQHQNYDLLVSKLQKGEVLPQDLTSDTRLLDIGDETPFADLGTKKLEMNAIHLKAAWDTKGKSTKEDWQEWLRRFSTTLLTESPNHALRACASLASVYLPLARELFNSAFVSCWSELYEQFQDELIQNIESAIKSENVPPDLLGLLLNLAEFMEHDDKALPIDIRVLGREAARCHAYAKALHYKELEFLQDQSSGAVEALIVINNQLQQSDAAIGILRKAQLYKEGIQLRETWFEKLERWEEALASYNKREKEVPADQPIPIDIVMGKMRCLHALGEWDALASLTGSTWANSAPEVQRMIAPLATAAAWGLGKWDSMDNYLSSLKRYSPDRSFFGAILALHRNQFREAIACIEQAREGLDTELSALVSESYNRAYQVVVRVQMLAELEELIVYKQCDERKQATMRKTWETRLEGCQRNVEVWQRMLRLRALVISPAENMRMWIKFANLCRKSGRMGLAEKSLKQLIGSDAPLEALIPYWNDTKGDRQAAAAAPRNVPPAQVIYGMLKYQWELGQQPSMKASGTAERTLYCLQRFTNDSAHRLDVAKAHLTAQAGSEVNLPLEYGFQNQVDPSVMSPQTQRALVDQTVLLAKCYLRQGEWQIALNKDDWQYTKIQDILSSYSQATKYNPRWYKAWHAWALANFEIVQTLSARGEGQLTRADQSMIIEHVVPAIQGFFKSIALSAGSSLQDTLRLLTLWFTHGGNSDVNTAVTEGFANVSIDTWLEVIPQLIARINQPNKRVQQSVHNLLADVGRAHPQALVYPLTVAMKSWQNSRRSRSAAQIMDSMRQHSANLVAQADTVSHELIRVAVLWHELWHEGLEEASRLYFGDHNIEGMFAALEPLHEQLERGPETLREISFAQAFGRDLKEAQDWCHQYETSRDVNDLNQAWDLYYQVFRRITRQLPQVTSLELTYCSPKLLNARDLDLAVPGTYRSGQPIVRIMSFDSTFTVINSKQRPRKLNINGSDGVSYAFLLKGHEDIRQDERVMQLFGLCNTLLANDSECYKRHLNIQRYPAIPLSQNSGLLGWVPNSDTLHVLIREYRESRKILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYALDNTTGQDLYRVLWLKSKSSEAWLERRTNYTRSLGVMSMVGYILGLGDRHPSNLMLDRVTGKIIHIDFGDCFEVATKREKYPERVPFRLTRMLTYAMEVSNIEGSFRITCEHVMRVLRDNKESVMAVLEAFIHDPLLTWRLTNAASPTGPNFRSEREVALAGPHAIRARRQSILDADVTPSELMANVEASAPPMARNRARTNSSAIPEAAQVNGADERESQNARAIEVLDRVSQKLTGRDFKPNEELDVINQVNKLIIEATKLENLCQHYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6X0</accession>
    <name>A0A2T4C6X0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1209779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6X0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6X0"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="534" mass="60050" checksum="17E5CE8E2D040B5B" modified="2018-07-18" version="1">MSDNSKLKPTLPHSLLFGHISILLQFRKHHPEDVHFGIIMKWLVDNCPNWIPDLKHNTPSPPPVLYLDIWPVFPDLMMMVFDGSLSAQFTQTKSLPKHRITRTFLEPLTDNLDMTSADGAQSKVWRSRFNSSFSPRNITALIPELIDEIVVFKELLAGLAGPEGQWGGVFQLEERTTNLTFDVILRATMDERLHEQINPQGSPLKQALISQIRLMSKVLGLNHILGIKRWPWDSLTRARNNEALRKALLGHVQDAINRSPPRVADALTEDKKKDKKKTILNIALDRTLAETGGAAPDKGDIEAILANLKLFLFAGHDTTSSTICWMFKLLQDNPDCLSKLRAELDNVLGDDPSQAASLLRDSPQLLNSLSYTNGVVKETLRFYPLASTVRQGEKDFFLTLPGSNVQYPTEGTAIHDVPSVIQLDESVWPRAGEFLPERWMAPQGDPLHPNKDAWRPFSMGPRSCIGQELAMVEIKLVAALVCRDFDVREAWEEWDAKRGGMVKREMVGGERLYGCGQTVQHPKDGMPVCVRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7E7</accession>
    <name>A0A2T4C7E7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7E7"/>
    <dbReference type="OrthoDB" id="4900091at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="439" mass="49321" checksum="8A53B4D3D2A15959" modified="2018-07-18" version="1">MKMVPQERVPYDPPPQRPGETDREYYLVWRNHFNLWLLQTIDDYFKAKGGRLPAPSSDIDDDDEREFFDRPVTYENQVFEIPPEFWERQLRETRDKGLPSKSSGKVEVSRSENGEVIQSSSSGSLQRPERDSSNIRRNIEHSEGPAAEQQEMFLSEIRPSVEQTPGRPQTENDMESSTPISSSNIEPTQTRKRRRLPAEESALGSSSKKQKTDKHPQLSTASNAAGCKRKRNAEEPLDEPSLISTPEQPTDKKRRLNTQRKIQSSRKRKRSSQEDDKGLQVSRVASEVPGSKRRRVSKTEVTDDASTAAGSRRILATASSLRITRARRRQLSGEDAQLLQLDQSGKPDVQEPKHAVHQPARELPATSRNGRRPKEAASMDHKNSRNPATTNYTKGGVKASIIAATKDTTSNKTSTKNNARTRSRNASGKSRGKGRLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7F3</accession>
    <name>A0A2T4C7F3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1213383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7F3"/>
    <dbReference type="STRING" id="983965.A0A2T4C7F3"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05510">
        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000072">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000032">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="339"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB77485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1139" mass="125103" checksum="FD89234F4F454348" modified="2018-07-18" version="1">MSVPNGQAAWPPPGLHHSSSSRSLQVADDGVARIATPVDNSMVLMPEATLDVEDERRRAHFADLYQKSEEKIALLFADDGSYNLNAIESLRRYPPTPAVTLPPTTDHEPIKEPPLKKAKRTIDEDDYDDDEEDEDDEDASSAVAKPPAATAAAAASNSLLSPTKSGSSPVQSVTSPSRIADKSKPQDGSQTKGKPEDDAIKQLEDARKATEAAARRSFHTIIYTLENDRTAMLEQQQLEDSEKQLQAEMENNHSASATGPQAANQGSLSSANLGASSLTLKHLIARIDMKRDQVKASDAELRLLMNEVRKNRSKWASEENVNQEELYEALEKVLTELKAHTEYSTPFLTRVNKRDAPDYYNFIKNPMDLGTMTKKLKSLTYKSKTEFVVDLNLIWDNCLKYNQDMNHPLRRMANGMRKEAEKLIPLIPDLTIRSRAEVEAEERRKQNGGEDDGGEDSDDEPIMSSRGRKATTKGANKSRKAPNDPKEDTPVVDQKPILQVNGLLGKLGREGSEMDGSNGFATPPIGGSITPGAANGPSGITSNADAMDIDGPSINGMSLNQAFGQASEQAYEDEEYKVWKQCTKKDRALVAKERFQLFKDNKLSVDAPALLRTKAGMRRFLAHQKEAGLSNGTDFDAPATTAKAAGSKAPETLAEGIEEEKEQVLPDYYTPMSNIPDIPPKMQWVEDGEGQVVNQHEEFLRLVPPGSFVASQSKLTKKMDENIHQIQETRKLAMKISVIKQMQVQSQVYTNQFPKSNSEPFRELDVEPHFISDDGPVMAPNTCQNALKRSIAKILYTTGFEELQPSAMDAFTSIAADYFQKLVRTFNVYREAEKKSVHIGGKTVLQPRFTPEEVILHTLDENGHDVASLETYVKDDVERLSSKLGALHDRMKSHLADLLRPALAADAGEDGAGAFNDGSDQFTSGDFAEDLGEDFFGFRALGLDKEMGLDFVSVPFHLLQSRVRSQYQMQAQASGESSSEIFEPLPISEPVTKENIQHQIGLVKNFFLAKLHANNDAPLVEDEDLPTKQRKPRPRLGASGKIISAQKRPPKEQLALAKKKKKLEAAAAEARQNASPDKAAAANAAGAKKRPANGNVPNPALLALAPSMERTDSMQSQGGMSQTDKDDTTGMMSPESIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7T5</accession>
    <name>A0A2T4C7T5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1430142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C7T5"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004282">
        <property type="entry name" value="PRK05691.1"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
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                <person name="Druzhinina I.S."/>
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                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
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            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="329"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="440" mass="47857" checksum="436A95169E826587" modified="2018-07-18" version="1">MMQSTSPFTGGAHQSPSFHSSSYLPKLEANFMRDFTCCGKILPNLHDLLQHYEEAHTQASPSAVRNSAFNQFGALGIQGSPKMPARSTPAPGQGSQQMGQQRQMGGPGLQMGGSQRLGSSMLQMSTSINNMNDEMDAVADMEMDDALGTMDMDDSQKMHQTRQLFGQQQRPQLNMNTSGITQGLRTSQPPTPAAQSFGFQNNPTVSSVNTPTLTTQQQMPQQQSQQTGMSEMDEDLPGMPMGGDATDLGDMTFGNGNNNNDGNDSNFCINDPGKHLFSPNGAFPQGNRSIQAQLAQLGLTHGQFADPEANKVLLARLQSMMMPEEHKPFKCPVIGCEKAYKNQNGLKYHKAHGHQTQQLHENGDGTFSIVNPETSAPYPGTLGMEKEKPFNCETCGKRYKNLNGLKYHKSHSLPCNPEFKLQALAAGLNLPGIGEDVMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9A2</accession>
    <name>A0A2T4C9A2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S proteasome subunit P45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1420306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9A2"/>
    <dbReference type="STRING" id="983965.A0A2T4C9A2"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="391" mass="43971" checksum="B52FBD73BEA447C6" modified="2018-07-18" version="1">MSAEEERQAALNAYRAKLIESREWEAKLKNLRLEIKDLQKEYDRTEENIKALQSVGQIIGEVLKQLDDERFIVKASSGPRYVVGCRSKVDKSKMKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFAGIGGLNDQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHASSVVIDGDIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRESVNQDDFNRAVRKVMEAKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9T7</accession>
    <name>A0A2T4C9T7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1329374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9T7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9T7"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF2">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015456262" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="40303" checksum="8F091E3E66595E49" modified="2018-07-18" version="1">MLLLPAALLALVSEVAAEPPAATAIKKQLPDPNEKLFPDHLAFEALPRSAPYEAANLWLDDDSSINSTERYHPAFSNHFQNPEENLFRRAANVLGILQNRAACPSGMESCSSIGADNKCCPDGTYCTDVSASDAGQVACCPDGATCGGGVANCPSDAASCPADLGGGCCIPGYVCLGIGCVPSASASGMPTPTGSPSSVSEAHSSPTASGATGAPPWRPTDVTSTSASVSSSSSVSSTAFSSTSSVPPRSTTRPGETQTGCPTGFYGCLATHGGGCCRTDRDCQTLSCPAPSTTIVSHGVTVVVPANDVPTATASDECASGWFLCGKDAGAVAGCCPSGYKCGTASCFTSSASETGSVQKQQPEPEAPNKSAAAVSMRCSHWLALGSVAGSLFLLSGNMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9X2</accession>
    <name>A0A2T4C9X2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1191177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9X2"/>
    <dbReference type="STRING" id="983965.A0A2T4C9X2"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="141" mass="16143" checksum="C22EF5917AED9FD0" modified="2018-07-18" version="1">MIRVLKHPQSGTRSLDALDNFIKNAYGLQTDAVKKPSEWDPVSKWSALRWYIDDKTQGDLVGEGREILWDIAELLISLLLYVDASTDGNEAAKEIFRRFVQDKFAKEKRQRDTTAEELKRDLAIVYGVEEAEAVSREISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA29</accession>
    <name>A0A2T4CA29_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cwf18 pre-mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1191849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA29"/>
    <dbReference type="STRING" id="983965.A0A2T4CA29"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23930" checksum="C6AC574180032B47" modified="2018-07-18" version="1">MNSHNSLSAAADERKARLAKLKTLKRKQPVDEVATPEGDRDASPAAAAAAAAEEHENDVATRHLSGRNYDPETRGPKLGFDAPPTLAMEKPTLEEQAAEVEAEIREQAAEEARDDRGLDLFKLQPKKPNWDLKRNLEKKLEVLNVRTDNAIAKLVRERVQSAQKAAQKKEDIDNGNLDGDAAGVDGIALVEGLRVREQEEQEDEERERREDEALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA99</accession>
    <name>A0A2T4CA99_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cutinase transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1351948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA99"/>
    <dbReference type="STRING" id="983965.A0A2T4CA99"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="606" mass="68901" checksum="155EAE96CA9C61DD" modified="2018-07-18" version="1">MLDEPEEETAMKDGPRDLLEEFAIESHPLEAPMSMEDLELLRADIDSDKSPRDLLLDMFDASFDLPKYVRPLTSLPPDDMEFLHAEGALTLPDSALQNALLRAFFEYVHPYVPTLDLDAFLHSIGTPDGSAGQVSLLLLQAVLAAGTAHVELHHLRNGGYQTRKQARTAFLKRVRLLYKYNCELDQMVLTQSLLLITSWQDASDEHGKTWFWIDAAVSHAFAAGLHLEPSVHKPNLSRRKQRLRRRVWWCCFIRDRLLSLGMKRPPRIRDGDFQVAMLEEADFQPEQIRSDDGDHARFEAACVYVRSRKKRAELARMCVAQATLCRSMSFLSSGMYVAPHDSSLSAGTRRAAADGGEQRLFTTYIRDLLEWRDGLPEGVSYRPISSSDIGRDGNTSISLDRAVLHMIYYAAVLCLYRSRFMVLQHDRADASAMEKEMCKIYMQHSAKRIGEISRNIYDHGLDRLLPSMAANIAVSAASVHLLELRGQLQGCGTEPSYRQSRRLMQSMHDIYAGADLSRESLKWHEEDEEEEEQQEEEKQEKSRSSGGQAAAETREEEEEDYLVADADWLKDLEAATCWYVAEPYRADSFLQYPGEGLDVVNEFFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAM1</accession>
    <name>A0A2T4CAM1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1328745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAM1"/>
    <dbReference type="STRING" id="983965.A0A2T4CAM1"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="57986" checksum="69BA3F597B6D0538" modified="2018-07-18" version="1">MTNSSPPTRNQLLPSPESGLLSRFLVEGRNNELNHQSALAAAQEEHKRVREAAIRVYELHELREEHQRILELERKEQERLKAEAAIVEEERRLRELKAKTVPKLPPEPVPEPPKKVEPTPVQPPEPSKVPPEPKKQNPFETKQQPISNNVAPQTNGFLGGQTKPAAGALFAPTAQATSASKIENRATPTAQAALAVQPPVTRSPAPPLASAQKNALADRYLEIHKELKKLRQVLQAEAKVPGSPLKGKMGTYRREIRVSIGQLTAGKGANAQPIAKITMALKEALDGKVPSAPIEVSRFVAGQRQPAEGAANNGDTLPSLFIYLLNICAKGIINQFINECSANPKAADPIGVFTAHIFSQKDFQWRGESLIDILMAKFRVVCPVLFGLKGSDRTERGRLAIGWKKDGPGYVTEQTHNDRMTGLGAGFASISLRDFSKTSKANPYPPVNYWKALAGIVNSSPNETSNTQYVVLRAMIEGHEQRFLNFYGNAAIAALRLALIEFPKKAPANAAAAHSLLAMVELLRNEGLVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBA7</accession>
    <name>A0A2T4CBA7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1329032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBA7"/>
    <dbReference type="STRING" id="983965.A0A2T4CBA7"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="294" mass="32616" checksum="754F7B16A58322D4" modified="2018-07-18" version="1">MDLSQQQEFIPQHDADTSIGPDDTIAGFDGASEAASSNGAHHQQSHSFDHSIAGSLRQEEDSPSRHTPPVSSLSRPASGLSNPAPPPYNDYRPSSSEQSNGRSHVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPVLVGTKYDHFVNFPIQDQEEISSQARRFAKAMRASLIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEIENVGEPLLLYQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBD6</accession>
    <name>A0A2T4CBD6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LexA/Signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1329506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBD6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBD6"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000015">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015781170" evidence="8">
        <location>
            <begin position="31"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="17932" checksum="CA50273284028326" modified="2018-07-18" version="1">MISHLLGHPLRFTISTLKITCLAHLTLSHALQVSPAQGPSMLPTFTVDGDWIAADMTYRLGRGVKVGDLVLYKIPIFATQNGVKRVIGMPGDYVSLGTPGEPGEEQMIQVPEGHCWIVGDNLPASRDSRQFGPLPLALIQGKIIGKILPWKDRQWAKNGLEKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBF7</accession>
    <name>A0A2T4CBF7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1329740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBF7"/>
    <dbReference type="STRING" id="983965.A0A2T4CBF7"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="242" mass="26377" checksum="DCFD6A64B9DE6176" modified="2018-07-18" version="1">MDQTYRSLADCLLCKWEEQRATVAIPNDTSALHSPPRLLVAVAGPPGSGKTTIANKVAEIINSLPPQSNNPKAIVISADGFHLPLAILRKLPNASEALARRGAPWTFDGHAAVSLVRKLKSDAPRRSILAPTFDHAIKDPVSDGLLIEADTDICILEGNYLLCDEPPWDEIANLVDEKWFVHVEPGLACKRVALRHLAAGIEPTMEQAVHRARTNDLLNGEFIVSKSLGRYNVMIESIEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBI4</accession>
    <name>A0A2T4CBI4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1373999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBI4"/>
    <dbReference type="STRING" id="983965.A0A2T4CBI4"/>
    <dbReference type="OrthoDB" id="4894353at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="69032" checksum="40C771314AD7BED5" modified="2018-07-18" version="1">MELSVPAAKRRETVDCFNCSASGRPCDRTKHRCETCASSSELCQGYPRALQWLIGVTSRGKLKGRSISIDASNTAWESTTPTNHTFIFKQGRPPKKGRLETRAPKQQWKSKPRSKSPHDVGDVSRLAESHQPSVPVELRPHKETAVQNMSEFDPSAPLGAALDNAENPGFQILSCRDDISSLAPLVLGSFNFTLKETTGAATDAGLSFPLIEAYDEGYSPPLIPQPAIGSSELLAFYDAELCTLPLTFDFSANPFRCNTGPSLRPQYLFHALLAFSIQHVSRLGDAMCKDLTDQQIASYRYSANNQSTVELIFAGESTKHFVVDTILVLFALDTLTSAAGPWYARLSDAYQKLETLGGVNAVACSSRFSAQIAMFVWWDCSISLISRSQPVFPSSYYDFVLSCDDSSWNIFTISGVPRPLFQHFRELLQLASEREQISGLRYATFDMSRVEELERCIQDYTEDGCEVCDTCADEETVQNAYDYHYASNTWKYALLLYIYRVFKWDRTSDTPMAQVSSLSRQLLDSARCCRPESSLQKQFLIPIFLAGAEATGDYARKFAKDYCVGWYKKSRYSMFLEAADLLEEIWAQKDAQSNAFGIWWGSVIGPRRSNAPEFLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBQ8</accession>
    <name>A0A2T4CBQ8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1349354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBQ8"/>
    <dbReference type="STRING" id="983965.A0A2T4CBQ8"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="272" mass="30288" checksum="6835C8D2C827C8C4" modified="2018-07-18" version="1" fragment="single">MMATVPTAGVDFRDLLRSGQFSDLTVVCRGTEFKLHKVIACLQSPVFLAAVNSDFQEGRTGVIKIDQFDPETVRRLVEFLYTGDYDRLPQEPQPVLEEQTQDTPSTVLHVRVNAIADYYGVKALGHLATHKVQQAFQDKWDPKTFMITAKEALGASGDKALHDSMARIAAQNMTDLVGCPELTDLVGDFAAEIMRHQGKKQADLVALRQHAEAETARLTAKFGKIIEEINTREYCRNTACAEASFGCNIEQVNSTVGEPTYILRCSYCRCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC27</accession>
    <name>A0A2T4CC27_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC27"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015406052" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7386" checksum="971D7E26E4C5C055" modified="2018-07-18" version="1">MSMVMVMIMVPAVIVHLFLLMLPTTRVSATIHSNNILPHPHLSFSPTSHIRHLKDFVSLEVGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCV4</accession>
    <name>A0A2T4CCV4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_48127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCV4"/>
    <dbReference type="STRING" id="983965.A0A2T4CCV4"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="149" mass="16599" checksum="CA109CC7A199098F" modified="2018-07-18" version="1">MSWFQKQITLPAKSRGSYLITDQILSALPEIQEYKVGLLNLFVQHTSCALSLNENWDEDVRADMSDALDRIAPEYGAKGEALYRHDAEGPDDMPAHIKSALIGASVTIPIKDGKLATGTWQGIWYLEFRASKHRRNIIATIQGDKGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD39</accession>
    <name>A0A2T4CD39_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD39"/>
    <dbReference type="STRING" id="983965.A0A2T4CD39"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49685" checksum="F9BDA8A9B77AF044" modified="2018-07-18" version="1">MAYSGSYTASFNPASSSSESFGSGLLASSISSLSSSGSKRISPVSKTYRQASTLFLTRRLPEALSTLRPIITPPSSADDGEPVPVAKSSRGTRIKVWSLYLTLLNAIVELEPEEGKEAFGNQEWRALCTKVRDGSIWEEVVKNGYHGVEGDVDADVVINLATLLLAHARDQSLNQKRLENFLASSNIPNLDLNDFTAPSRRYQSPARRANGANTPGDLNSRVKLLELYTLHVLPQNNEWEYAREFINVSAVLDEERREAFLQALQSLQEEQEEHEKREREERQRQEEQLQKDIAEAKRLKAENEEKERKRLDEKRQHRETSEGDYGIEQTPSFSGVGRAQPPGSPQNNVARPPRPTGKARSKATTASGSTTITARATMILSRFGHLFESLASSFRGNPAVVMKLLVFTMGLLIMLGHKATRQRLEQIVGKAWAKVAATVGMGTKVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDH9</accession>
    <name>A0A2T4CDH9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1174465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDH9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="172" mass="19915" checksum="3E926F7F35AA1CEE" modified="2018-07-18" version="1">MTFCYTTIHHHHHHENELCYRHAECLALGTFLRYPICQGIAPPWGTTFSGNVGEEKYDDDDDDVRAEREADTTWVGKKGGKGRERERERGIMLAMAQRMERERGTWVYRVLLSLISLLHCTGSCFTCMDLFRVLFGSLSLLLFSSLLFRYFFLALFFFFAMISLLGMDQAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE47</accession>
    <name>A0A2T4CE47_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1429076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE47"/>
    <dbReference type="STRING" id="983965.A0A2T4CE47"/>
    <dbReference type="OrthoDB" id="5142935at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="531"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="767" mass="86381" checksum="66C17182E8188292" modified="2018-07-18" version="1">MSKPEDYAVGWICAIGTEYVAAQSLLDEKHGTPSSVARNDNNDYTLGRIGEHNVVIAVLPDGEYGIASAASVARDMLHSFPNVRIGLMVGIGGGAPSPDNDIRLGDVVVSAPRDGIGGVFQYDFGDTIQNQVFKTTGFLNQPPTVLRAAMAGLKAEHESEGHQFEATIRKALDKKPRLRKKYSRPAQSSDRLYQSDIVHPIDSEDSCSVVCGDDPMDLVSRRNREEDEDNPAIHYGLIASANQLMKDAIMRDMLAAENGVLCFEMEAAGLMNQFPCLVIRGICDYADSHKNKEWQGYAAMTAAAYAKDLLYRIPPNKVEAEQRIKDTLSHVVSNVDYMKSEWDRKEDLAILDWVTPINYGPQHSDFFNRRQPGTGQWLLESAEYKSWWAEDNKTLLRTDTTVSLFATSRPIPAIEKEFEGNLRKEVLANEQDMCRYIRAHMKDLPDFLSNMDDLKKEIKTEILQAAQGMFLLVHLNLDSLKGMTSIAEVKSTLDRIKSRKRTETGQDEGQTALRQAYDEAVERIDKQSPDQKCLGRNALEWITCAKRPLTRLELQYALAIKPGDIVFDPDNFRDIDSIVSVCAGLVTLDEETNIVRLVHYTAQEYFDSRKEQLFPDAETKMSVFCCEYLSNISRSGDSRDRSSEAFLQSNPLYNYAGQNWGHHARLVPQIPQTVRDFMTCPTTIEAAAEALDHDGEEWNGLHLAAFFGICKAIDFLPRKRRDLKLRSRYWMTPLRLAVHNRDQDMVRLLIEKGAAKKPKGSKTFVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEE3</accession>
    <name>A0A2T4CEE3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_16315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEE3"/>
    <dbReference type="STRING" id="983965.A0A2T4CEE3"/>
    <dbReference type="OrthoDB" id="4850804at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="94443" checksum="9FE9BC0D8DD40C5C" modified="2018-07-18" version="1">MASQYSSAAPLPQGFSVYQPQLGAQLQFFPALGTQELDDMINAYIPGAAPLKEKRASISLDFLEHSQLTGQTFKFYPVYYSSSPVAASPVNSIATSSFSNASPATSTLDWSQTSASPSVSSRSSVSKSRKTSKSSGLAARYPAVDLSHLPGMKIMTKDGQDITDSASRGSKTKEQRDHAHLMRIIKACDSCRRKKIRCDPDHKKRSASQSQPQSTAKPAKKARTTPPAAGTPAPATSTPSPQKSAPASVAISSLDDNPPIPMSLLGLDPTFTFTGLDGLESADQMFESWEEFVQYPPADADDNYDFFLDPEGYFSSQSSASSSSASPSKALTPASQQDAQAAAGPGEREGLPSQSASPQLPFLQDSYTTSSGSYTDFNLFSPSSSFSEDDRMVPISSTRLLSPAQTSVSGSEPFASEGFVADGNMLSSNWDGTSAPASPLDTASLTAAAHTDMSWYDPGHSEVESGEPGDSRGGISTIATTDWAGEVRIAYPSGGSVLVTAASGSGGVEVIANSAPLGRSDVYGSGSGSGPVSVSIMGSGPSVALESSPSTSTALQVHPDIQDEVLSYESSPTERGRFPSESPVNHSSWLSPGRAGSPTESTSPFSSQRGTTPAAVATAAYDPVQLSSSPEEPPSRVCDATASANYHSVRLTRSKAQIQLAANHNVTSENLSGGLRASSGYALQAVPGSTVHAAAGEDTLSLRTSAGSTALAWPHRPGVETLLSVTSLAAQQLDGGVDEHQQAVTTAADNGLQTLSPLLLQAISPNESLTAAGGSAYFRPGQWSSQSVLRQVLMQAIGSILAATLLGATLASMAGAFGMFSLLSMSLATTAIFQRLGEVKAPFETKPPAMSSPRFNEGLQVWGKKPHGKKAQQPSVLRHEASRLSSRFSSFLRGTRPLALMAPLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEK6</accession>
    <name>A0A2T4CEK6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1107771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEK6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="19162" checksum="360FC367713C6BA8" modified="2018-07-18" version="1">MTEYRSLYCTAQFPVQLTWPYTPQSLRFLYMLRHTHSRCCEKQAMSASSRISYNVLLLQYSVHTGRPILCPSPVSQCGSTAAATYCGPAMTFKQKALTITVLAWMSGRTRKIPRASSVSTCDGGCSFHVHSSSSLPLALPPCRLAMRKVEDSTARTPYLVGEDVSQAHHLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEN8</accession>
    <name>A0A2T4CEN8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_176149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEN8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="12829" checksum="A9728F83D974F20D" modified="2018-07-18" version="1">MQRHDAAIKHLGNHWASLHEPQPKRTRPASRESPRGAPAAKELTLAAPLWFWPAGDGALRTAPPIGSLHCGGWNGGEDRRRKDPSTELFVQFILDECVRRGPQAEPWLFRDTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEP0</accession>
    <name>A0A2T4CEP0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1109035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEP0"/>
    <dbReference type="STRING" id="983965.A0A2T4CEP0"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="329" mass="33774" checksum="6D97EB645D5D9F58" modified="2018-07-18" version="1">MSTTFLSGAAFGAAMMAASFHNPAIVIAQMKFENWHMMQAFLAATASSAAMYAVADQLDYVKLKPRSSSPLGLFSKYDGNIIGGALLGTGMALSGSCPGTLYAQLAAGVHTGFHALNGAILGGLLWTGLLSKIVKRRKERADISSITVTANDQLGLSRGVTLLIFETVCISVLAATTIYTPKFPGAKLVGTAGGFLIGLSQLFSLATRKSMIGISTVYEEVGNYFWWLTKGADPSAKPTSYNSILFAGGVTAGAWGLLQAIPSLAGTPVFEAPPLLAMIGGALMAIGARMAGGCTSGHGISGISLLSLSSMITIGSTFAAGAVVAPLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF87</accession>
    <name>A0A2T4CF87_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrophobin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1397521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-ulmin hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF87"/>
    <dbReference type="STRING" id="983965.A0A2T4CF87"/>
    <dbReference type="OrthoDB" id="4500971at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23508">
        <property type="entry name" value="hydrophobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.120.10">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010636">
        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101751">
        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015438779" evidence="4">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="86" mass="8788" checksum="81F816ED3A82161A" modified="2018-07-18" version="1">MQFFAVALFATSALAAVCPTGLFSNPLCCSTNVLDLVGVDCVTPTAAVPDGVFFQAHCASKGKQPLCCVAPVAKQGVLCQKPIGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG04</accession>
    <name>A0A2T4CG04_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1128258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG04"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="69" mass="7950" checksum="78584442868E81CD" modified="2018-07-18" version="1">MKLIVRHEPLRHLDEQKARSCFHAVHSFFVAADTSSYRARLSLFSESIIVSPPSRTHEKQRALISCTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG39</accession>
    <name>A0A2T4CG39_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_196568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG39"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015710747" description="Secreted protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9357" checksum="556F13C27ECA6B1D" modified="2018-07-18" version="1">MHRVVWSITPLVTAVPRRTSWLAWVCLFLLQRGLSDRLWPGSPQRRSYRIGRNGVSCFFQIFSAKVAEHGVMLIWVICVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG92</accession>
    <name>A0A2T4CG92_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sterol desaturase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1467793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG92"/>
    <dbReference type="STRING" id="983965.A0A2T4CG92"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="304" mass="35593" checksum="44635881D4B24496" modified="2018-07-18" version="1">MEVANATFSALNQTQGYLNVLEEVGKYNVHLNYFERLWAAWYLYMQNDTLATGIMSFVMHEVIYFGRCLPFIIMDKIPYFHKYKIQSQKMPTLKEQWDCASIVLISHFTAELPQIWFFHPIATYFGMDYSVPFPSLFTMAWQIAILFVMEDTWHYWFHRALHYGPLYRSIHKMHHLYSAPFGLAAEYASPIETALLGIGVVGSPILLLAITGELHLLTMYAWITLRLLQAIDAHSGYDFPWSLRHFLPVWAGADHHDMHHEKFIGNYASSFRWWDYMLDTEAGAEAHKRRREKKLAQIKAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGV0</accession>
    <name>A0A2T4CGV0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1419297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGV0"/>
    <dbReference type="OrthoDB" id="4900077at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="69" mass="7491" checksum="EC45BD26CA3F213D" modified="2018-07-18" version="1">MPASPPSAPPTWFDQGCRAPLFQERKRDHGASTSHTTVKMIESCSKPTNFGRGAYDTTGLPKPPPPQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGY1</accession>
    <name>A0A2T4CGY1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1325579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CGY1"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="634"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1554" mass="171043" checksum="6B1E3BD238BDFE35" modified="2018-07-18" version="1">MATPSPVRSVRPASPSLHHEIPRMQYRSRPVSVAVDPVSLVISECIAITSAIQKHARSSHFSVSAILGGNPNTIQFGSPSPRERGAGGGPFRDGDRDEAASSRWSFQGQRAKGLQDSPMITGFSNLRHEITGVQNIHSFDALTLLAPFLFVIQEKGTAAPITILALGALRKFLAYGFISPESPRFALAMQSLSAAVTHCQFDISDSAQGEVVLLMILNLMEDMMSGPGGYILSDESVCDMMGRGLAICSQPRFSPVLRRTAEAVLVRMCQIIFEDIKHIEVEAGDASSVMDQLADQHMENVKMDTTAGSAVAEPIVPATTRDGPPSGAPDSGDAEQAEEERADVEKADQGPVVNPDNEDNGESDTESLDLRPYSLPSVRELFRVLVNFLDPNDRHHTDTMRVVALRIIHVALEVSGSFIARHPALATIAKDQLCCYLFQLVRSDNMAILQESLTVTGTLLATCRGVLKLQQELYLSYLVACLHPTIPIPREAGIDPSLYAGIPETPKLVKPPPSQTNSGRATPVPVKDRQKLGLEGGARKPDARQAMVEALGVLSRMSTFATELFVNYDCDEDRSDLCEDLIGLLARNALPDSATWSTTSVPPLCLDALLRFIQFMAERLNDEPVYENCPDPEELRERRRRKRKIIIGTSKFNEKPKLGLSYLEANNIITDVNDPVSVAKFLKGTSRISKAVLGDFLSKKGNEAILAAFMDLFDFSGKRIDQALRLLLETFRLPGEAPLIAAVVESFSEKYCDCNTICEVANKDAVFILTYAIIILNTDQHNPNVRNEKRMTLNDFSRNLRGQNGGQDFSPDYLRDIYETIKANEIILPDEHDNQHAFDYAWRELLVKSETAGNLFPCNTNIYDGDMFAATWKPVVSALSYVFMSATDDAVFARIVTAFDECARIATKYGNVEALDQIVYCLSHITTLATRVPFNTSLNTEVQVGDGSVMVSELAVKLGRDFRAQLAVLVLFRVVTGSEALIQNGWKHIIQIWIHLFLNSLAPPLSSTDLPTLPIPAIPLQTPSQVIDRAARSNDVGFFSAFTSYISSYAADDPPEPSDEELESTLCTVDCINSCRIDKVLNNISKLPPARIDILVQALLDQLPESDHSAVIGVKQDNVTVIPPNGPGSSTGLPSYDPSTPFILELCTILAIRDGGCAPATVKQVLDAIHGVLRDHSQWHGITVSRAAFYGLMILKSGYDHDFVNVPIFLHTISSLPQDLLLKTADIILSGLSLCTREPGPLRSEMMTSPDFWVILRVVSGDANAAAQIFDILERSTTGTPPAIMADNYEAVISLLSHFASAADPLATRDPKSPEAARKKVDPQVTARGCQAVNTLYGMTARIPQLMQQSHLESSEAWSAYWLPILQALTTQCTNSCRDVRQLAFSALQRSLLSPELTCSDPKEWTAIFSKVLFPLIFRLLKPEVYSSDRDGMSEMRVQVASLLCKVFLQYMVVLSEWDGMLDLWIKIIEIMDRLMNSGQGDSLAEAVRENLKNVVLFMATSGYLVSPDKDPSRKKLWDETWERVNRFLPDLRNEILGEEAPEPGEAKEGEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH53</accession>
    <name>A0A2T4CH53_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1434821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH53"/>
    <dbReference type="STRING" id="983965.A0A2T4CH53"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="366" mass="38316" checksum="4D552F59410E93A2" modified="2018-07-18" version="1">MDPSSGPPRPPAAADAAAPDTSSDTPPVATHLARFEFSDHGTKILMVEWYPGAPTLSGQDTTAPSVDDVSHDKAHDGAVDRASGDDRDDNASAAPARAPSSPVGVHDDAAASWEVSWAGKSTFLPARDTDDDDDARRRVYFMLPPDAPVPATVTVACPGRPSIVLKPLPAIFPEHFHIESGPRGVLHTIWAKKRLRELELEMEAELRANAESVGLEMALAEKQWIVDNFLRAPPSSPLPASSNSAAAATSPRSPISGRLGDKLKGLRLATSPADLVPNPAANTFTSPDSQSHMLSPLGGDIAVSSFSAISRSRPTGPMSLDAALSGGAVPLQPDAQDAEDDLFALPMSPRSPDMIKSPFSALGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHR5</accession>
    <name>A0A2T4CHR5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_76528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHR5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18076" checksum="7ADAA68A959949B0" modified="2018-07-18" version="1">MHLISRRETMLQRHALVTSCMRVHAPCQAVDRPSCQNAADIAEQGGFPRPVICKVHMRPPRSEVETSSQSLASYPNILESSICNQSSLHGPSGLLERWLRFTSLGRHHVVSCPPSYSFLRFDWTPGALSVPALRPVVLLFDQRNAVRAPPGGQIRVTGDALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIJ6</accession>
    <name>A0A2T4CIJ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIJ6"/>
    <dbReference type="OrthoDB" id="4886852at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34083" checksum="CCD8671DB369C433" modified="2018-07-18" version="1">MALAAIINPIDTSEALLFYYEKVEDTYSLAVRHSSVSGGRDQYFENRNTIGTRVKPPPSDLAVTSFLGLVRVFGISKIPKVVKSADPDIAVISQLSPVVNPIDKPSAATVQPGDYSAISACGSVTNTGYVSFLKEVGGVVSLVNYTINKSVSPTHKTVDVTAAAYSKLASIVVKGKPWVFFQNKAGKYLYYHNILAGETFRIPTTGMAEQGTHLAVALSPDNSILFLYYRNQDGNIARTWLHNGKWAPEEVAAEDAMDDDSAIAVVNHEKNLHIYFWNNGDVIHDVNDLPDESQLGASHAAGFHAVRAVPAESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIK3</accession>
    <name>A0A2T4CIK3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1466883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIK3"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="89"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="383" mass="43454" checksum="B036B0FA32BB8FB1" modified="2018-07-18" version="1">MASTQESPIVSNSTQDRSVWKPRPTQKAIPNFRDILSQENRTQSSSSIFVVVDGKETPKPAKEPKESIMEMVKEIEAGDSLDETLRNEHAVIIRDTKTGRGHGLFATRDLLPGHLLLSEQPALSFWIPRDVSMANMRRDFEAQWCDLLHHEQEALRAEFPQLRPVPSGRWTLSLFQSIMLYNFALEYSYSSPDGDFANIYSLASRINHACRGCANAVRGMDWYEPHRILITLAKPVKAGEEILIHYNTMEGSKLACADEWRWRFGGRSTRASEATSAETMEEEEDVDFNADVPGPSLSVMDRARWLRNKAVRRWGHLFTGEGCGWMRPWQSPPWQSPPRTPYPRSPSPEASSSSIPILRAPPPTTTGSPVRRQWRNRPRGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIT1</accession>
    <name>A0A2T4CIT1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1322700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIT1"/>
    <dbReference type="STRING" id="983965.A0A2T4CIT1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="337" mass="36093" checksum="F4AC809776B9177A" modified="2018-07-18" version="1">MNFDYPTHGQPPAFSNPWSSSPSPSQTAAVAGSNLYVGGPQPPSLNHNLVHKSHSARAPTSSAPPLSSYASMPVHTTAADLLNLNRLQTSSAAYADATYATTASPVHGHFAPPSATPYDALGYAPAPVRPPAFSALGHETDASRRFSQHVHADDRRGFAEALDASQGMLAMSQETPRNIYGNRNDRSSVDSYGFPSTHSTSSSISSSGNFSSYYGDSVSDYSTAGSDIESVGSRTLPRPQGMMSSMPPAPQSMMGQFSSKVSSSTQKKHKCKVCDKRFTRPSSLQTHMYSHTGEKPFACEVEGCGRHFSVVSNLRRHRKVHRGDARSEAGSEDHHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ17</accession>
    <name>A0A2T4CJ17_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1018049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ17"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="98" mass="11576" checksum="86415383DBAC14E5" modified="2018-07-18" version="1">MMRWIARAASWTAFARACPRCFRDPPVHMGRKRFTSTEMRSWWAFFFFGGRLMRYTTGYDLFFFPLSLSFCLSLSFCPLFSSFHSLAPFNSLMMCYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ26</accession>
    <name>A0A2T4CJ26_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1323092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ26"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ26"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="189"/>
        </location>
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            <begin position="122"/>
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        </location>
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        <location>
            <begin position="84"/>
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        </location>
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            <begin position="210"/>
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        </location>
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        <location>
            <begin position="371"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB81518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55337" checksum="7603B714DD290D04" modified="2018-07-18" version="1">MPSNQVSRELEEIFKELGISQYLDAFVEHGFDTWDTILDIQESDLDALGVKLGHRRKLQRRIANARGIDPGISLSSVQAAIEDEKYDGSHRKREAPCHAGNGGSGTAKRKYRRHPKPDENAPPRPMSAYVLFSNKLREDLKKDPSLSFVAIAKLVGGNWQNLPLQEREYYEAQARADKERYYREMALYKQTPQYQEYMKYLQDFNEKQAKLRRDQENAKRIAMRGSTSTASGSGSSSERMRESESREPPSLRHNSSNSMHSPSGTHHTVAGSGTFPALAQPNGDMSTQSESRSRRRYSTARERERQADTPQQALPSVFDLLSDRQGQPSVPVTNNSGLIHGSAPADHGRRSISHGTPSWPVDSRPPLPHEPSSGGSSIPTASSSSLSSRLSAGHVPIHALLSDEGQPPQRIDEVPSYTPHYVASPIEQKGPSLEYQGPKGYGFQIASSAFQHMRFEETSNGDVLMTSANEPSPSASPMALSGLDGVNALLRAGEIVGQPRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ88</accession>
    <name>A0A2T4CJ88_TRILO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">M440DRAFT_1396800</name>
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    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="54" mass="5981" checksum="7E4FD355741AED0F" modified="2018-07-18" version="1">MNPYIASCPVRLTRAHLIVSEPYPFGSEGSLWLTHMLMSQSLISRTEALCSVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJA5</accession>
    <name>A0A2T4CJA5_TRILO</name>
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        <submittedName>
            <fullName evidence="3">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="112"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="29036" checksum="C2DCD0CE8D1E99EC" modified="2018-07-18" version="1">MAPETRRASKTGPEYELIYWPGIPGRGEVVRLLFEEAGVPYKDTAKGSRAVPTVLAHSAPESTGDASNPPTFAPPVLRHGELVINQLPNILLYLAPRLGLGPASGNGVYHLNELALTILDGLLAEVHETHHPIATDQYYDEQKDEAKKRARAYREARLPKFMGYLQRVLDGEVSTSGGGGWLYGEFTYVDLVLFQCLDGTKYAFPKTVEKLRKTGKYDGVFKLYDAVRERPKIKAYLESDRRVGYADGIWRYYPELEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJI9</accession>
    <name>A0A2T4CJI9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJI9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJI9"/>
    <dbReference type="OrthoDB" id="5387995at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="416" mass="45778" checksum="421828EBA12A079F" modified="2018-07-18" version="1">MSSLEPVQTLRCHDALVEAGPIGAGLHSLGAAARPRLSSMSRALSRRKSSDFLLEAPHRHRLKSIPRKPPPPPPPPTRTLSSSSTLRAHPQPDNLIQFALLDRTTLTAFTFTFIPDNNNNNQKAFPSRRGVKRCRLGSDVEGPNTASVGRKKRRLRTRLITSPLSQPFSQPATHILHREGRPVGDRRFVKMAAMLDASRRAAHLRATAYLRYSIVNRMRKRMGPLPPRCCNYQADAGQAEDGSRSSTVRQGSDTFGRAPWQVQAVKSGYEAGPGFSETRRGAPPATASHEPGETLAKAPACRLSKPIALPLPSADADATDDRPSARIDSTTSSPEPRPPLAWMYDDAEEDSFAHLHADEEHLDDDDDDDGGDVYCNFDAIFAVRATSPDPQAAPKDDHTYEEYMDELDGISWRVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJL8</accession>
    <name>A0A2T4CJL8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1346915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJL8"/>
    <dbReference type="STRING" id="983965.A0A2T4CJL8"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="13770" checksum="DA252A2800CB2850" modified="2018-07-18" version="1" fragment="single">MPSPQAVHTDAAPAPISLFSQAQVYNGLVYCSGNIGLDPKTGKLVEGTVTDRTEQTIRNISALLEAANSSLRRIIKVNVYLTTMDNFGPMNEGYAKFFCAPFPARTCVSVAGLPMGSDVEIECVAALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJU5</accession>
    <name>A0A2T4CJU5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAS complex, SAS5 subunit/transcription initiation factor IID, subunit 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1368225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJU5"/>
    <dbReference type="STRING" id="983965.A0A2T4CJU5"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="251" mass="28749" checksum="925CFC51CA7A9A78" modified="2018-07-18" version="1">MMLRSRRGAPRAAKLGSTAEPEADGQQRKIKVVTEQHVIDKPSPVAEFPMRQWSLQLHLLDEEGNERPADVFTKVVYHLHPTFENPVQTFTKPPFICSNEGWGEFEIGIDLYTTEKTKLAPIIHDLNFAKERYEVTHTVVFKNPSQALQERLRESGPLPSDEDRPKKKGIAGKKSAQKYDYEKIADALEKLEEEDLLRVIQLINENKTPDTYIRSDVEVNNLFEAGEFSIDLYTMPDTLTTKLWDHLVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK27</accession>
    <name>A0A2T4CK27_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1368452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK27"/>
    <dbReference type="STRING" id="983965.A0A2T4CK27"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="109"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="602" mass="67573" checksum="AC41BDE51BAF864D" modified="2018-07-18" version="1">MAHSPDLKQPKDEFLSHVEDASPSFSRNVNAKIWNPLMGITKEDLYSQVTAFCREYGFQDKQDTFFRGALAAQSPFDYEAIPELTDDDKYWLRREVTHRWHLPRALYYTIALCSLGSAIQGWDNTGANGANLSFPQEFGIENNGWLVGVINSGPTLFGLLSAWAADPVNNLLGRRGTVFATGLFCIFPVLAQAFTQNWWGLLICRLFMGLGMGIKISTIPVFSAEVAPASIRGGLVTSFQLWVSFGMFVGYCCNLIFYRVGKLAWRFQLASAFAPAIPVVIFVWFCPESPRWLMKKRRYPESFQSFCRLRNSEMQAARDLYYAHCQVMEERDPFAGVSFLHRARELVTVPRLRRAAVASGWIVISQQFSGINIMAFYSSTIFVEAGYSTLSSLLASMGFGLVLFVFAFPAVYTMDTFGRRNLLLTTFPNMAWCLLAAGLCFLMSTSNSARIPCIAFFIYLFTAFYGPGIGPLPSIYFAEAFPLSHRELGAGLTICINNAVGSALSLTFPSLLKALGPTGAFGFYAGLNMLAFVVIFFIVPETMKRTLEELDYIFGVPTRRHMSYQVGTWLPWWIKRYIFFQRKAKLEPLYKLDGVDDTAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP14</accession>
    <name>A0A2T4BP14_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1426883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679207">
        <property type="protein sequence ID" value="PTB71054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP14"/>
    <dbReference type="STRING" id="983965.A0A2T4BP14"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9304" checksum="FCD083A68BF36533" modified="2018-07-18" version="1" fragment="single">LLDEADAKVQTAPHLLLASKDEPADKVALYKEIMGDRIEVTTYENMHHGWMGARSDLKNEENVKEFERGYKQVADFFAKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPH3</accession>
    <name>A0A2T4BPH3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-Aspartase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1153213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPH3"/>
    <dbReference type="STRING" id="983965.A0A2T4BPH3"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="145" mass="15993" checksum="BF9F6A6F01002194" modified="2018-07-18" version="1">MPGKVNPTQCEALTMVCAQVMGNNVATTIGGMNGQFELNVYKPLMIRNLLHSSRILADGMRSFEDHLVKGLQANEEKIASIMKESLMLVTCLNPKIGYDMASKVAKNAHKKGLTLKQSAMELQALTEQEFDELVKPELMVKPKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPQ0</accession>
    <name>A0A2T4BPQ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1365821</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPQ0"/>
    <dbReference type="STRING" id="983965.A0A2T4BPQ0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015500620" evidence="14">
        <location>
            <begin position="22"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB71256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="494" mass="55531" checksum="6A76BFEE538692FF" modified="2018-07-18" version="1">MYSYILAISILAYWIVKRVVASTEERIVARKNACQPCARLPQRERVIGFSLFKQDAAAAREGKSLQTAQDRFRSLGDTFSGVILGQFFISTIDPENAKALLSSQFGHFDSGKKALFGPFLGHSMLTTDGAPWKHSRSLVRPHLGRNQAEDLSKLEDCVQSFFACLPKNGSTVDLQHLFFRLTFDNVIQLLLGETVSTLDCQPGSELHMVIEAFESIGDLVNRRATLGPLLRFYRDSEMTAACRILHDFVDRIVEKAFRKRNTSKGSTPPGSFLENILDSTDDLVKIRFEVLGLLLAGRDTTAGTLSSLFYILARRPDIWAKLQTEIKRLGGRKPTYNDIKGLKYLRQLIDETLRLYPPVPVLFRAANQTTILPRGGGVDSQSPVLVPKGTVISCSTFSLQRRQDVYGLDAEEFRPERWEILNAHWNFLPFSAGPKVCLGQTYAYAQMAYIVSRIVQHFERIEERSSEPWVEKWSIILMNASGTKVGMIPRTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPR2</accession>
    <name>A0A2T4BPR2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1473620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPR2"/>
    <dbReference type="STRING" id="983965.A0A2T4BPR2"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="657"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="846" mass="93106" checksum="3AE41B6830216EF2" modified="2018-07-18" version="1">MEPSSKKRKLAPKVTTSVAPNPQPAAQYSHETPPQQQPYPVHDATLAERQDFEAFARHLQDAAMLIQRQTERPPHSDVSVLLLSWEEDHTVDEDVAAVEQVMQKQYGFTTKRWQIPTVPNPSIKLGVQMASFLENARPNHLLIIYYAGHGYAGPDGQLYWACNAREDAAKLKWDGVRCLLEDAQSDILLLLDTCADPEPAAAGSHGMKQAIAACSPEHKIRREPGQRSFTSFLVEALHKLSGGQRPFSVQRLYDETRALKQQQRARSPPPPNGAASSASPIMPIFFTLTPGKAQNLMLASMVGRAPVGPANGDASDGQNSRSREDQIIDPESVADIRFEEARILVCTTFVGDASPDMSYFHQWLQNKPTLGASIAVEGMFLGPPTMLLISMPHSIWNVVQHDKVCCFLGYISSHNMIHLYEKLVGPAGIRPSAKEVEDGRILLEARELAAGTPSRARREPDQYLHAAARDGLEYRSQSSPSGTNYTPAAPRSIAPIKPKDEVEDSAEMQEAAEQLKALSHVRPRSDDGPPPAVAAQPPAPPVVRHRTTLPDGIPERHIEPNLTRDANEPGVDAMAVDAAPSLRMKAPRRSLPKQETRCDHCTHAPFKDSSSLRKHIAAAHTRPFPCAFSFAGCASTFGSKNEWKRHIASQHLCLTYYCCSACPQSSAEGKGNEFNRKDLFTQHLRRMHAPFQIKRTIAKGDSKLQAEWDAHVKEMQQSCLVTRRHPPQKSACPRKECNALFEGPTSWDEWTEHVGRHMEKGEGQRLGIDKLLADWALDEGIIELKSDGGYRLCATNGVLPSGSNGNPPMELAHKESTASLPENASSADEAQVAEVKSGDDMEMAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPS4</accession>
    <name>A0A2T4BPS4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPS4"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="38340" checksum="8A5A17B1116CC7D6" modified="2018-07-18" version="1">MSSKAHLTLTPSSRVALLRSQAQAGKSKLPIKNVHTHPRASSAGKEDASVYFIGNATTILEWGDFRILTDPNFLHAGDHVHLGPGVTSQRRTDPAVDLDQLPPMDCILLSHYHEDHFDQLVEESLNRDFPIITTPHAKGCLTSSSKPEPFRAVHALDFFDSMLLKSPPNTQTETATPVIKVTGMPGKHVPPGPLSTLNDLLSAVPPTNGWLLELGWADTSASAKDDEMKTGYRIYISGDTLFVDELREIPKWLNGKQVDLMLVHLGGTTIPGASAPLVMVTMDAKQGIQLIHLIQPDVTIPIHFDDYDVFLSPLSDFQDKIEQEGLKERVVYLNRGDQYRFSVPRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ44</accession>
    <name>A0A2T4BQ44_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_217867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ44"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="206" mass="22441" checksum="6E9EC5A4861CCE41" modified="2018-07-18" version="1">MGGPEGKKRPGEETKQNVPCESLDQQTCRHSHTRWAHSPLNTTAQHHHRSSAPLRSHSSNSLTQSITHSLRPSRGGATDHCIAPFVIVAWVRKNPLVSIQIPSFSFRVPNVPDEAVEPCALRLALPRWSASIFPDILCPSSFPQSESSTHHPCPPDPCPSYHSPDQPRPGHIGFQPISAPPAPAFLCPAPLPAGRTLSASKHVPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQA9</accession>
    <name>A0A2T4BQA9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPCR, PTH11-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1146586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQA9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQA9"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="47"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="351" mass="38968" checksum="ED4549F12338FF46" modified="2018-07-18" version="1">MTSQWLVGGMPPPPGVEPNFIDPYDHMSENIALHSTLLTITTLAVGMRLYTRAIITKAKLGVDDYFCVISYCLVVGFSVFMFLCYNKGIGRHLWNVPVQYVVDMLKFFTIGSYIYLLASGCVKLTFLFFYYRIFAGSVKMRYLIIAGIVLTFGFTTSLFFGTVFSCIPVERAWNPTVPGHCLNPIYLPYVSGISSSALDLYTLVLPVPVVVGLNMDLKRKLKVVAVFGIGLFACAASLVRLGMTPILRSNPDASWNLSWMAVWATVEINVGLICACLMLLPAFLNHVLEGPIMNSMSRLFSGAFGRISGRRTQESKSPIGGHDTWVPYVEQRDSDSQFKGLNSHQMTVRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQB3</accession>
    <name>A0A2T4BQB3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1343951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQB3"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="491" mass="53528" checksum="6A695E870C0FA3AA" modified="2018-07-18" version="1">MDAKLEEANASQTQDVEAITIFKDELPASQPGAMSEAEKKLLWKQDIRIIPISAGIYFLCFLDRANIGNAKVLNVTTHDDLQHTADMSNRQFNVALMVFLVAYAVFEVPSNILLKKLRPSRWLAFLMFCWGVITMCMGATNSFGSVTGVRFLLGVFEAGLFPGLVFYLTFWYRYTERSVRVAFILASATLAGAVSPFGGAIAYGIGHMNQVHGLAGWRWLFILEGIPSCLSAFLVFFFLPDYPESATWLSESEKDLAVQRLYHEGSKGHHPSMTWEDAKTTLTDWRLYAHYAIYFAVSPPFASLSLFAPSITSGLGYVDLEAQLMTVPPWAVAYVCQVLVAISADRFNARGYHAAGAALVGAVGFIASAALPATAYKARYGGLILATAGSFASIPPMLGWLTSNVVSTASTGLAIAINVSIGGGFGQIPGVWIYKADEAKRGYPTGHWTNAGFLLFVVAVCLGLRVFYGRKNKALVAYGEREGVSVRLYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQY9</accession>
    <name>A0A2T4BQY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1442444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQY9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQY9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF219">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="548" mass="61045" checksum="9CAB14957673DF62" modified="2018-07-18" version="1">MPGTAAVKHLSQISAAVNRKLSLFWGEAMGGSTRINAMVLTRGSPSNYNDWSQQYGLKDWAWEKVEPYFMKSENAIGHPEAQYRGHQGPVENRQMALPFSCYPYIETAVRKLGFPVYDDCNNPAADAQGYFSLDHTITASGLRISAYQAWLNKDVATARKAHLTVCTGVTGNKLDIDPLTRRVVGVRIHRNGKTGNGDYHVRVRREVVLCAGALGTPPILMRSGIGPKDQLDQLGIPIVQESSAVGDNLMDHIAVAIMSKLPARDTIHSLYNPLVFIWQLILWIFFGRGLLAHSSTSSTIFARTTAIDDTTLQVQTSRDGIDTMDAMNPQNVPDVEIMVIPVSCYLDVNVTAHPLMTWQCTLVQPFSKGSLRMTSRNPEHLPEVIHPLLRDDRDLVPMRKAIRMSLRLGQEFARSGYPHPAPVLYGPGMDLEHLDSIFGYATQLPSKQEKKKGGISELPDWQTISDKAIDEYAYRTYQSTLHYACTCRMSLDPADGVVDQKLRVFGVDRLRIADASVFPKVPSGHTMAPTMMVAERCADFIKETWRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRE8</accession>
    <name>A0A2T4BRE8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_8634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRE8"/>
    <dbReference type="STRING" id="983965.A0A2T4BRE8"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="52"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="290" mass="32009" checksum="755C1FB227B8ACF8" modified="2018-07-18" version="1">MAARKALIEVAKETQSVLPSIVQQLPNLNPSSSKRLDYKTLPALEASSCPKRIHNGKLTIRVIQEDSLNAAIRLANTRSPKSGRVVVLSNANARTPGSPWLQGAMAQEEEICYRTSLSLSLHEDLYPWTGTQGIYTPDVVVIRDDVKSGHNLLHPDTEAAKLPVVSVISIAAPTRFKRTMEQITLNNGAQSITVKRAIYKNPQDRDNMKMKMRFCLRIAASKGHGLLVLGALGCGSFGNPRDDVAECWLEVLREEEFGGGWWEEIWFAALDPRGDGNFGVFRGVLDGVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRK8</accession>
    <name>A0A2T4BRK8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1442247</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRK8"/>
    <dbReference type="STRING" id="983965.A0A2T4BRK8"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="441" mass="48670" checksum="944CD2CB8BBECEA9" modified="2018-07-18" version="1">MDFYQVNLAVLIVANSCYFIYRHYTHDRKRRRRGAPRDEQGEAVAQGFKRRFLLVYTLVVAADWLQGPYTYAIYKYEKELEEHTVALLYASGFVSGAASAPFVGQLADRYGRRAACVAYCVCYSITCLTMLSRNLNILYIGRLFGGIATTLLFSAFEAWMITEYHQLEIDESTAPLGRIFANMTTTSSITAIVSGVLGNGLVQWFGSRLSPFFASFGCCIAASILILATWRENYGSAAKPLENPGAQKLKHRVLAALTDPRVVILNFASCCFEGTMYLFVFFWSAALKSLRANSGRQDELPLGLIFSSFMCAMMAGSSLASTRTASHSSYSALNTLMFVYAIASGAFALSTMLEGEHALFWAFCVIEGCVGAYFPKMALIKSDIVDDSARGGVYSALRLPLNIFVVVAHSLDRPGDEHRNLVFLFCAALLLIASLVISRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRS3</accession>
    <name>A0A2T4BRS3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1442288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB72011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRS3"/>
    <dbReference type="STRING" id="983965.A0A2T4BRS3"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="213"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="464"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="592" mass="66081" checksum="F133A8CFF3555028" modified="2018-07-18" version="1">MMSLCRRRFPPHWPPLPTLQYRATVQAGRNSRHLSVQSSLRSKQTPDFGSGFTGSYDPSVESGRGPMFRKVNFGVPKFYPRDLKRRVDEYVVGQDRAKKTICAAIFNHYQNLRRRRQHEQEDKEKHEKLLRQRFARDRELSQRRWDSSPLEGKFTAHKVRLRCMPVTRAPQDEAPGQTSSTRQTNDYNATESGSSAAILKSGEPAIPEHVKIDKSNILVIGPTGVGKTYILETLSKKIQVPLTICDCNSMTQAGYIGQDVESCIERLLIEANYDVKAAEHGVVVLDEFDKLARRETTTGRDVSGEGVQQALLKLIEGTKVTVNAKDNRSSRTASPIPPNYNAAGAPTTSMPVSSPPGKVDQYTVDTTNILFVFCGAFVGLDKIILRRVSKPAMGFGGDVQSRHTGTAGSYTLPPETYSHLAHYSPHAASTFTPLDLVSSDDLQRFGFIPEIIGRLHNFCALSPLSKEDLYRILTEPRNSLVAQYTALFETYPSQLFFTEKALSAIAERALASETGARGLKMEMERVLAEPMFDAPTPYVLVTEACVKGLEKAEYWGKDGRHELLQRLEEERFHPPSPPHSLEQLRQAGEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRX0</accession>
    <name>A0A2T4BRX0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1364104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRX0"/>
    <dbReference type="STRING" id="983965.A0A2T4BRX0"/>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43350" checksum="E4F8131BF5FF4AA5" modified="2018-07-18" version="1">MSPPYDNHGSSRSRRGVWSHWVPLAITLTVATAGLAAWVWSQRKESAEDHAEPEPDLDYEHADYGENPAYGASAEGRRMAPPEQRDGNYAAGAEMDEGASGWGSRMTSAFSSNPQTFLDSTGKTVAAGVAAAGAAVGKALASIREEDKPEPETNPWSENREVRREKGPAPVQKKRKTVAIVISADSQFRDDDDDITHEHASILNHIPRLNDLSAIKLFVLIYAPSLKETGEAATSNRPPPSVSSSFSNVGYDQAQTPEAKSPVLGASAENTLFNAVYSQALALVDKETMILPFTTPNGHTHILRHLQPDVIYLQESLAGENGGYVANMQTWFRHDIVLVVGAEDGSGGLADSESETEKADKPDKWWQKPERVGRGRGIIVVDSVRVNDDWVRRVQGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS38</accession>
    <name>A0A2T4BS38_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1405865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BS38"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015672402" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1566" mass="170952" checksum="1AD39D8809E17984" modified="2018-07-18" version="1">MRSLRSLLLGIGALLQVPAGALHIPVIAENISYPFHDIHHPNGAPLVRRDDVLVDLRIMPLGASIVHGIGSEPELNGFRGYLRQALRHDGFQVDMVGSMQTGTIEDNDNEGTPGAIIDETENHFDNSRVLKPNVVVINLGTNDANRNIDVANGKTRMRNLLMHIWASDGMADACIILSTLIPSGLASGQQNNPILNKGYRELVTELQGQHCIYLADMDPADGPAHGWLAPDINPDGIHPNKVGHSKMAYVFWQAILRAYNDGNIMDPLPIDDSQPNPGTGCDKVYNSGSYAGLTQLGSGADDGIYYHSQTSEGILLNHTSQYDQGQFFFAALYGRTYDDFLGWYNGSDLPYQNKFAVWKNSGGVFTRIADLDPDLHCLPRGIQFIDMNSDGLDDIVCIDPDGNAYLSINQGDGTATKPPTFKRVSATAKIRDTVGFKQNRIRFADIDGDGRGDYLALDDHGNIQAWRNGWVDDIPKYWEPLGTRFLAKGKDTIDGVRMLDINGDGRADWLFVDKTGGVETWTNSRTCQSGRSGDGLKVDWRQGFALGASSGNTHPGVAKAGDGDIRSRILFGRVWGVPQDFGNFGRKDYVYLEHSLDGTTHTFRMRAWKSAGHGGSKVKADGVKYCNMLNHPNGEVDYVWTWSNGKMIMYPNAGKGTVADGESYWGPEVTIFDPKALIGKDLDRRDLHLMDWDGDGDCDIVWTDPDNDNRPSVWLNLYHTTGSWSDAKTWDYFPNAQSSASGVSCKEKRGFNLHDHAVQFADLDGNGRDDFLCLRRDGYISAWLHNDDNSWSSVGQVKFAEGKDRANLRFADVNGDGKDDMIWVDKYFGDGYVYYNRGPGDRAADAGSYLHWDHVSKPVYNSDRAGTCVYFEDFDGNGVADIHAIRDVYSNKAATWLSPSCSVKNNKGDGGTCCDDPKLPVQPGTTAGGPGGSGGGGNQCIKGHGPDDFDTLCSFACQYGFCPSPCVCDERGTPESEPPRIRPPGVPASDKGREYSLLCAWSCARGKCPSGICKGSPGGVFAYNPYPDDNTDPDVIPTDCSFYGYAVLKGCNVESWKEDKSYDPIGADQDCSDPAKASYPWKCACHNCGKAGNDLSLGPAERWNSVYAQQCMEDLTNWYWQETEAGRVDASQRSLPDVVGKNFGGLDGNCAFKSPPGFLCDVIGDSGCIPVRCGTTLYAAVDLVLNSFYNVFNVHNKMYHSLDKVAQDVTHAADTIHDTFSTANKATLLETLQTVFDVFDGIFSIAGAGIWEKFLSAGVFKALTSGVEKGSELQESINGAISIYKAAAGDAKTAKDKDMDDAKEIEDAAQVLADAAMEAIDGFMKFIYSAGYFGTAALQNLLSGGVFLDDPSAKYSELDFSSMFETCIYSQLIQLAWRLGTNQRPVVIYAKPDVEAPDDLDRSAIISGEEAAKVRYPGNYKASNGKEYSLFLFGVGFFQEAAAIELNVLKGHDDIDDEDNQWGVTWRDIVESSFAGFIAAGKKNPYPLAEPDSFGDADSGNFFAHQEGVKSAGFASLPVCTINLAFENVIHVSPDYCDEYPCCERTWSAATHACKGLNEWCEPDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSA8</accession>
    <name>A0A2T4BSA8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_8438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSA8"/>
    <dbReference type="STRING" id="983965.A0A2T4BSA8"/>
    <dbReference type="OrthoDB" id="2564987at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015520275" evidence="2">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="195" mass="21225" checksum="1A3540598DBF26CB" modified="2018-07-18" version="1">MKSQFLTSVVFLAPAVFSQAVIDSGTGFGTYYYDVEQVEACGTSFANQNLGFVECNLLTGLSLNDIDSNYIVAMNHTQIADNLAEYCGKRVVVTANGVKSDLPLFIGDGCQRCGTGSRTNTAWDPNGAPGLDFSYTVLSELNSNACFAGHIDISWEIVDETLYDFDTNAPGQPTGPVNQRRSVSQRSERATRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSB6</accession>
    <name>A0A2T4BSB6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_68341</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BSB6"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="515"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="763"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1335"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="327"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1525"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1530"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1579"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB72200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1606" mass="181975" checksum="4F3FA63567F1D931" modified="2018-07-18" version="1">MNPSSRHSAFSLRSPSSTHTQAEFHPPLPYASDHQSPPRLNPNPSASRSPYMASSTPAAPGAAAAPHALPSVLAPAPGHHQSQSQSLREHQHPHHHQHQHQHQQAPSASPLHPPGAYYPPPPPRSTVSSVLSASPPPAPAPAPVLTAPELHPAGGRVYDPTTDTTKERPIAASRQHAPPVATPKGRASDIRGEDASKKNRRPSIKKESPTPRPPSKRQANGQPKQKTWSSEMERSIQHHEALLDKQAESLDEDEFSERAYKEGAFKRQRTMAQLDADRAYARREQFANTTGKRLAEHSDLGKRRYDDVFYDEALQEVREQELFAEKERKKDMQRKRRREKSMAVTIEQKEAALARAEAAEDEEERQKHLRDAERANKKAQQTKLILQKGIKGPARNVELNLDGGTVSSFIASDAETPKKSKGRGGPRPKKSKEQKQAEKDSAEAAQAALDAGEELPPKEEGRVRIKIKGKSKGGDGEKAAKEKAEASKEKEKVDEVPDLEKKFISKGYNQIYDQIWRDMARKDVSKTFKLAVDSYATRGSNLKKTAILASKEAKRWQLRTNKGTKDLQARAKRVMRDMMSFWKRNEREERDLRKAAEKQELENARKEEADREAARQKRKLNFLISQTELYSHFIGKKIKTDEVERSTDNPDVASDARQIPENKLSIQEPTGPLASRVTDFENLDFDNEDESVLQAAAMANAQNAIAEAQKKARDFNNKGLDMDDEGEMNFQNPTGLGDVEIEQPKLINAQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTVQSISVMAYLAEKHDIWGPFLVVAPASTLHNWQQEIAKFVPEFKILPYWGSASDRKVLRKFWDRKHTTYRKDAPFHVCVTSYQLVVSDVAYFQKMRWQYMILDEAQAIKSSSSSRWKCLLGFHCRNRLLLTGTPIQNNMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLRRVKKHVQKELGDKIELDVFCNLTYRQRAYYSSLRNQINIMDLVEKATMGDDQDSGTLMNLVMQFRKVCNHPDLFERAEVTSPYSFGYFAETASFVREGSTVSVGYSSKSLVDYELPSLVWTEGGRLDKAGRDNQTAGWRNKALNHMLNIWTPEHVQASVDADKAFSWLRFADTSAGDVYKATHSSLFDRAVDEIKKRDRLGPMSVAYDEDDDNFTPAHCLFKIRERRDWRPLAEVSSEGILSSLMNVAKVSYRDSGLGRLEPAGRPRASAPPIQVSCNNPNAVAEHRNVLFNTHIRKTLYGPSIYDEQALVEKKVPMELYPVNKVLPAPDHEKKRFTNIAVPSMQRFVTDSGKLAKLDELLFKLKAEGHRVLLYFQMTRMIDMMEEYLTYRNYKYCRLDGSTKLEDRRDTVHDFQTRPEIFIFLLSTRAGGLGINLTSADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLITRGTIEERIRKRALQKEEVQRVVIQGGGASVDFSGRRAPENRNRDIAMWLADDEQAEMIERREKELLESGEYEKQKKKGGKRKRTDAPASLDDMYHEGEGNFDDGSKIGASGTATPAEIEPKGKKGRAKSIGKRAKTAKQRLAIADGMIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSS4</accession>
    <name>A0A2T4BSS4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1394981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSS4"/>
    <dbReference type="OrthoDB" id="5220127at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="13584" checksum="24C4CD9314BB3A8A" modified="2018-07-18" version="1">MCQYSFVHYHHQLPCTHPASLVPRYSYCAAAAINPATNQYSPCAATTVFASPEDTGEDPCARGNCLISPACSSGTCRLQDLNGRWVCCKCKRGGNVYRSCHHRKKGCPDTFCYHDICDGCTPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSZ0</accession>
    <name>A0A2T4BSZ0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein ALB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSZ0"/>
    <dbReference type="STRING" id="983965.A0A2T4BSZ0"/>
    <dbReference type="OrthoDB" id="5422107at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12308" checksum="3BA22706BCB98D38" modified="2018-07-18" version="1">MANVKNPNRISKNRLAARAAKARKANLKRCNPANQDKVAKADRTRGARPGLLPTSGPRKAISKKKARKLEKKMGYELRRRMEAEGEAVMKDAPVVEEKKVQEEQEMEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTW3</accession>
    <name>A0A2T4BTW3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1079809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTW3"/>
    <dbReference type="OrthoDB" id="10594105at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="117" mass="13524" checksum="B6E4E9F94C0FA565" modified="2018-07-18" version="1">MPRCASFRTSAAQHSKAKHSTAQLLASSLRVHGSVSARIHRHHRSSPLPSLQSSDSNQTDEQANNSQPAKRKKRETKSPAPYRQPRCYARLAKESPVGKSRWRRDCFSLFDRRWWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUB2</accession>
    <name>A0A2T4BUB2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1384275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUB2"/>
    <dbReference type="STRING" id="983965.A0A2T4BUB2"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="493" mass="53990" checksum="E798C92C9EC31DB1" modified="2018-07-18" version="1">MTSDEERTALLGQDDTCNHGYVPASVARRLYVSHFLSTWNSRVFEFGAVLYLAVVFPGTLLPMSLYALVRGLSAIVFAPAVGWYIDTGNRLQVVRVSIVFQRLVVAASCAIFYTLAADVPISSGVRAGLLAVVTVFACVEKLCSILNMVSVEKDWVVVVSHSNAEALRALNAQMRRIDLLCKLFGPLFIATMDGQSSRVAILVNFGMNVASLPVEYLAIARVYHEVPELQAPKTRPQRSTAPQQESPHATESTISNAWKSLVEMVRQSGWDFALYFKHRAFLPSMAGAILYLTVLSFGGQMVTYLLSSGYSSVQIGIARTFGVIFEVLSTWAAPWLMGRIGAVRAGLWMSSWQVMMLAAGVCVFWIFEGENSIVSASGLVGGTVLSRLGLRGFDLCVQLIIQEEVEAEHRGVFSSVEAAFQNGFELLAYASTIAFSRPDEFKWPSLISALAVASASGAYAVFVYLRRGHLLHLGALASLLFTEKWRQNVHGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUP6</accession>
    <name>A0A2T4BUP6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_67850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUP6"/>
    <dbReference type="STRING" id="983965.A0A2T4BUP6"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="691"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="742" mass="81746" checksum="06A3041BD435F180" modified="2018-07-18" version="1">MSSVVGVDFGTLKTVIAVARNRGVDVITNEVSNRATPSLVGFGPKSRYLGEAAKTQEISNLKNTVNCLKRLAGRAFNDPDIQVEQQYVTAPLVDINGQVGAEVNYLGNTERFSATQLVAMYLSKIKQTTANELKQPVADLCLSVPAWFTDAQRRALLDASEIAGLKVLRLMNDTTAAALGWGITKLDLPGPEEKPRRVCFIDIGHSNYTCSIVEFKKGELAVKATAWDRNFGGRDFDKALVDHLAKEFKGKYKVDIHTHGRAMARTIAAAEKTKKILSANQQAPVNIESLMNDVDASAMVTRQEFEAMVEPLLARVHVPLEQALAQAKLTKDDIDVVEIVGGGSRVPILKERIQEFFGKTLSYTMNADEAIARGCAFSCAILSPAFRVRDFTVQDIISYPIEFGWEKAPDIPDEDTSLTVFNKGGVLPSTKILTFYRKQPFDLEARYANVEDLPGKTNPWIGRFSVKGVKADGKEDFMICKLKARVNIHGVLNVENGYYVEDQEVEEEVKDDEKKDDKDADVSSPNILVGSINASLADTTCDQAMDTDSKDDGARKTRKVKKQVRKGDLPIASGTSSLDANTKSALIEKESSMVMEDKLVADTEEKKNELEAYIYDLRAKLDEQYADLASEEEKAAIRAKLESTEDWLYDEGDDATKGVYVAKMDEIRALAGPVVQRHFEKVEAERRAVQERVEAEQAAKRAAEEEARKAAEAEKAAQGGADQEMKDADAPQPEIEEAGDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUS4</accession>
    <name>A0A2T4BUS4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1383223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUS4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUS4"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="623"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="110971" checksum="0050F77C062DDF34" modified="2018-07-18" version="1">MASTISLKELSKAIKDFIVDPAVPLPDDLVDTIAAYLRKREKYDDAASDRLQEELLLIFDKNVRGNPAAAGAWLGILRRLLTVLRTSERILVWLEACKGILDKTGFDKNVVAEAMEFLNEVVAIFDEHHDDAGDDSAVSPIIDRLFEIWMEEFQPARFEGYQPSEHSEKMLGDALANFGKRRPKEFFSSLDGYLIKKKYRKASLNFICSFIQSQPPHLHQVAQTPLFTDLLTCLQQDTSTTVVSAALTALIMLLPHMPSSLVPHLPTLFNIYARLLFWEKERSGTLESPFHDSEQASRWEVYAFEPETEDTNIAHLSHYYTILYGLYPINFMDYIRKPQRYMRHANVSNADEIEVQPTEIRHQSEQFRRIHVLHPNFYTLTIETEKTDVGRWIKSEAAEVVAECMALCISPDSQMFGDHDLLHLAQSSTQALNDDLSQLRTDPGLLSSSVTKVNSWRNTHLSMTESIASDHTPQRRGSQSSHHSARDSGEAVRARDFGVESPSGTQLLQSASHTQLQDLIRSNKAIKSSLHQSLANDSVPSLALSHQESVADRPLTMMTLPPQTQTPVSADNGNNAQIAHLQRQLLLLQNDLSFERYLKQQHMAHIGELRRRQMAEAATEAEMQNLIMMNRNLKSRYEEAKMAEMQVRKESEKSRAMAKKWEADLANKLKNLREESKKMQTEIDSLRKELEESLRECEKLRKLVCDAEVKELNARQNMQSIEIHGAEIDRLKAEVERLSLSERDYQAREVERMAAVNAAEDAQNQVETLRLQLAASELEVQRTKKLFQSQVAALQAQLSEAREERNRPATASVAVENALAASRAKQAEMQKQYSLLTRKYTVLQSSLLDMQLEASVATEKSSIADGEEDGMSSSTGPMSMKSRPLRLLSTAEAGEGSGYNATSSPGSNPGTPTSSVLQPLQPTSSAGTAGTDGQGSSINLSMSPERSYFSGGLQSMMRRDSKDKKDDSGKPKKEKKSLGLRGIRGFVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUU0</accession>
    <name>A0A2T4BUU0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1340708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BUU0"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="466"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="693"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1480" mass="163884" checksum="9AC24D88CFC4D3E5" modified="2018-07-18" version="1">MAATDSSSSGSHQLRPGSETPTATATARRPPALQTRDSTLSNTTTSTSSSGGYWSRVETTSTDQTFPSRTASDDARPPTPNRDSIVSIVDDPFFQNLDTPTAVAPDPYKHLEFESETLAEIPIFSPEATRGNRHVQEGHQKQHWPPPRRESLTIGSTPVLTQPSSAMESYNIAIIGAIGVGKSTFVQRILGLSRPPISTASSVRISVDSASYMITLLELDLDSFELNTPQPIQWPKQINGHIVPRVDAALVLYDVTNKDTIRELPQTLAALTNSNMPAMLVATKCEAPEEHRQVSPDDLANHTLFRSCLAHFKISSTSPEIDRGCLHAILKAAVSHRRDEIGEMGAARKRAQSAANLEAADPSGARPVSEGRHNRASSDFSLLRGFVAPSVDTPVADGHVQKHASRSPHRASMAVVVGPTLTFAPLPLGGRGTDSYLDADESDTDSRRYSDDIPILQRSDDVVVEKQQKMAGVPFDELVDRLLALRLSRADLNFSDVFLCLYRKFAAPGELFSAILMRLDRVRDDKTAHHLTKTATQLRIIETVAKWVSLYPGDFARLATRRNLDEFIRYLSTEPIFCIAARQMHRNLTLHVIEDDDTGWANADDADDQLASDILSKELSELPAGLTALQFGDEDGNFDRPSVSSENLNRVVGSGGQIQLYSYEDYEREAATLDPTDHLPMNKFRYRIFVEIKDDEIADELTRIDWIMFSSIRIRDFVRHVSLGASQKESCKSLNNVNRMINHFNHVAKWVANMILLRDKAKHRALVLEKFMNIALKLRQLNNYNGLAAVLAGINGTAIHRLSQTKALVSPETHKKFARLVILMGTQKSHFAYRLAWENSPLPRIPFMPLHRRDLVSAEEGSKTFVGPNGDRINWKKFEVLGEVLLPLMKSQGSPYPNLSKNDNVRELILGCHMTTDEELSQEIYQRSLEVEGSSSGGGGLEPTKKIFPWLKRISLLLKRAATRNGCHTDTMRLASVSLPKLQLASHEQRLGFALEGSLQLRFPNRTRLPKTSSDLLKRAKEKHLWIARTGSCYFQLEVSLQGEPVSEEDQVAKLAEWVKDCEVWSRVGVCLQHQERGVGEPTGRVAFSIQHPDLSSSLVTQKDAFAAEFESVTCRVDLAPLQEEPLKEKQSLKRKRDSQPDKAIRTQQLDGVSSDDQYLACLSADDQRVIDEFIRSLQIVSPQQGTVEPTPKATRSSPVIEFSDRFKQLFETALVILVLGSVKMPKGIVTVECNRAECLTRLAPAVFSMPYLKIISDRAALLPIIATSLARMRNAESPSLRQKAASFAARVTDTECSLNDRVVRGIEQSAWHVLLSTTKISKPPTRLGKGGQVVERAAPTAEYKQSASSILPQVVDRADGAEGALTATGSSIHDHMGDGESTSFQQHSPQCLEPYHSLPHAETTKATECEFKADPNYTFLGAMEDPFMTEAAMLNYDPLPVDIGSTTFDEWLCTSGSEPEYLGYSRPTYIDLGASSDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVA1</accession>
    <name>A0A2T4BVA1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1783-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1441456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVA1"/>
    <dbReference type="STRING" id="983965.A0A2T4BVA1"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="231" mass="25101" checksum="7E4D66D9AD145F9D" modified="2018-07-18" version="1">MIAGIARRRLLAAASRQAGCRSGKPTNSNASVRAVQRRWMTPAPKPGDGPLMSRRADRELPDVGQVSHGWRRTLPIFLIVVAACSVTIFNYQKSSSPIISSTLYALRTNPEANRLLGGEIYFKHQIPWISGEMNQVKGRIDVSFAVRGTKGSGVMRFASHRPSPKAFFETTVWSLTMDDGTVVDLLDGGDPFRGLLGGDDGAEEDGDVLVLGNMAEDGQTKGFRQQGALNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVB0</accession>
    <name>A0A2T4BVB0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase I-specific transcription initiation factor RRN6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1433364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVB0"/>
    <dbReference type="STRING" id="983965.A0A2T4BVB0"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="3">
        <location>
            <begin position="112"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="4">
        <location>
            <begin position="892"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="115370" checksum="0EF4BE7FD36769F9" modified="2018-07-18" version="1">MADWWPHPLMGLGTPGVLNYIPGEHPGEGPGILETSRFTSRCPHFKVIGAPIETYSASRSQLPETSTRLWEERQTQQRWLFKFHPDIAFGNTAYQDILKEDMAALNLSDEAPNTRPLLAIGHVPDPSDKAGIRKLPITAVACGEAGELLRLARMEDVQLQWRDDADAFLNIETIDPTQRDAEAIWTNDGLPIRQIKFAGNRLQDDTLRWLLLQKETATTILRPEFREVPTTSDQPKGSLIRERPSLIKPNPLVTISHDQTGGSPHSDVALLTTTHGRSHQLAIIDEGGYWSIWDLIGAWQVQRKGAPQFSLSKCGHISDGLLNELPTRSPFPRERHGILFLEGVWHGKLESSPSASTGKATDPNTRYLLMWNHERMEVLNLDTNIVLPRLGRIMRQRGKLDWILDIHRSPTRQNHVFILTQYHITWVDVFSRDESGLGPLKPSVLLSCPHLGTKKDDSRMFVCRASDDDPDTSLVFIYYPRKGQLCIFWFTYSPVTRMPQWHRDIISLPGSEDREFPAKNVVEYLRVDPVQLAVSVKANPSSPGIDYHRRGVRFYQLTFLGRDFSLQRCLCVTTEDPKLDIQEPTSAVAWAEARQQKQREKRRKVIMSQVSSSFILPDEMTMDDVEALLNGEEAEDEEDFDGDVASSVLSRPTRIRVDQIYQALQGSLEASISQGESGLPCQLFEALRQCLSDGFDQGRLPLLTWREVAEKMLRDSTFEPPDETMRDEMETLLDENNEKTIVTPLYQYNRDEMLLSLVSLQYFQRYFAELWIDPVRNILSEDMHQIRRIWVTELARDVFLSSYGIMYQDIPLLGPASSELPEEESQRSRTGPQFGSSQIATSSRSSSRDWASSPAQSPAASTTFVGPDEAVQRLRLLAKSIDTDKTDASRRSNVLAYWPKERGVDLNEYVSSVARANEELFRDAKERLQKMEARRKARSEKFRRPAFMRQGLPDINPMSSMAPTRPAPMQIMSSQGGPEATQTQVPVMTTMSQPVSGLFGDRKKVKKKQKKKLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVR8</accession>
    <name>A0A2T4BVR8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1404406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVR8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVR8"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="115"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="277" mass="31045" checksum="21662F9DEA4E8CE5" modified="2018-07-18" version="1">MLPYHNKSTSRLARIMHSLRLRPARDEDVPAMAALEVAAFLDSPMHKAMFPKRLRIKPGVQDQLEWNVARMRKGLADPSLHYLVVLTDAPGRGEIIVGCAEWAAPARGDHGEDEEEGRRRSEERERDLELRMARLPPFLDKSALLDANDEVMELIEKSKGAFRGQDRHRMWTLNSISVDGDYRGIGVGKMLTRWGMERAERDGTGIWIISSPLGLQLYRSLGFEMVAEGSRLGEPQYLMLKFYEPGMKGEERIGDGKDIKETGNINETGTGASAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVU3</accession>
    <name>A0A2T4BVU3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1339997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVU3"/>
    <dbReference type="STRING" id="983965.A0A2T4BVU3"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="383"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="428" mass="44614" checksum="9C4488498B5AF021" modified="2018-07-18" version="1">MADNAEAGGDAQVTFKVKTAQEGSHTITMPESATVLELKTKLSTPEFENIPVERQRLIYSGRVMKNDDTLATYKIKPNNTIHMVKSAASNAAPAASSSTPTPAAVPTNMASGTANNPLAGLTGARYAGHQINLPGMDMFGPDGGMGPPMDEERLSRMMSDPNVQQSMNEALNNPDFINMLIDSNPMLRNIPNAREIITSPFMRQMMSNPQMMSQAMRMQRAMGRGGDSAFPAPGATDTTPEGAPAADGTAGQGATPQQNPFANPFMLPGLMGGAGGANSLSMLQQMLNFPPPPQAGTDAASTAGSTTTGTGSATNAANTSAGSATTATTGTSQPQEAANPFAALFPPPAAGGANPFAMGPEQFQQMMQMFAPQAAAAPADNRPPEERYAEQLRQLNDMGFYDFERNVAALRRSGGSVQGAVEHLLGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVW5</accession>
    <name>A0A2T4BVW5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVW5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015513207" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8197" checksum="8ECD163ACF89CF89" modified="2018-07-18" version="1">MGCCLLLLPWCCVALRCVALVCTLRYDIVIIEQNSRESIHTASTCKYGRFCMRMRVLRGHHLDWASGTCSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWF1</accession>
    <name>A0A2T4BWF1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M440DRAFT_58810</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWF1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWF1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="37"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="243"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="509"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="608"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="710"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="788"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1162"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PTB73644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1262" mass="142554" checksum="9756C04A674C96F4" modified="2018-07-18" version="1">MADYEDDYDYENYGDEDEGITPEDCWTVISSFFETKGLVSQQTDSFDEFTQTTIQDLVNEYSTITLDQPNPPSPPGRTIALRRYEIKFGSVMVSRPTISETDGTVTSLLPYECRDRNLTYASPLYIKITKKLSAAVEREIPLHEMDDAQQEEYARTGEAPTKLEWEEEEAGEEDHNIGKSDDWKDMVFVGKLPIMVKSKICHLSRETDDSLFLVNECPYDQGGYFVINGSEKVLIAQERSAANIVQVFKKAQPSAYTYTAEIRSALEKGSRLISSMMLKLYGKGDSARGGFGQTIHTTLPFVKSDLPVAIVFRALGVVSDEDILNHICYDRNDSQMLEMLRPCIEEAFCVQDREVALDFIGKRGNRDQAGLGREKRVRVAKDILQKETLPHISQTEGSETRKAFFLGYMVHKLLQCALGRREPDDRDHFGKKRLDLAGPLLAKLFRGIMRRMNTELANYLRRCVEGNRHFNLAVGIKPGTLSNGLKYSLATGNWGDQKKAMSSTAGVSQVLNRYTFASTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMCYVSVGSPSEPLIEFMINRGMEVVEEYEPLRYPHATKIFVNGVWVGIHQDPKHLVQQVVDTRRKSYLQYEVSLVREIRDQEFKIFSDAGRVMRPVFTVQQDDESDTGIPKGHLVLTKDLVNKLAQEQAEPPEDPSMKIGWEGLIRAGAVEYLDAEEEETAMICMTPEDLELYRAQKAGIATEEDVGDDPNKRLKTRTNPTTHMYTHCEIHPSMILGICASIIPFPDHNQSPRNTYQSAMGKQAMGFFLTNYSRRMDTMANILYYPQKPLGTTRSMEFLKFRELPAGQNAIVAIACYSGYNQEDSVIMNQSSIDRGLFRSLFFRSYSDQEKKVGLNYTEVFEKPFHQNTLRMKHGTYDKLDEDGIVAPGVRVSGEDIIIGKTAPIDADTQDLGTRTTMHQRRDISTPLRSTENGIVDQVIVTVNADNVKYVKVRVRTTKIPQIGDKFASRHGQKGTIGVTYRQEDMPFTREGLTPDIIINPHAIPSRMTIAHLIECLLSKVSTLEGMEGDATPFTDVTVDSVSELLRKHGYQSRGFEIMYNGHTGRKLRAQVFFGPTYYQRLRHMVDDKIHARARGPVQIMTRQPVEGRARDGGLRFGEMERDCMIAHGAASFLKERLFEVSDAFRVHICEICGLMTPIANLSKQSFECRPCKNKTKIAQIHIPYAAKLLFQELQSMNIAARMFTDRSGASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWJ2</accession>
    <name>A0A2T4BWJ2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1381490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWJ2"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015635661" evidence="8">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="300" mass="32147" checksum="70CFA489A1E93A75" modified="2018-07-18" version="1">MELLLPLIALSSLTSITAAQIQIPNPPIFDALDPRFNEWQAPGPDDSRGPCPGLNSLANHGFLPRSGKNITAIDLVRGTYSGYHALPDIALAAGTAELIKAYRLAAFDLHELSNHGFVTHDCSLARGDASTPNNNDFNATIWSVPLSVLQNYSIITTEAIGAARTARDLYDIAHNPGQQCGARSIAVGALENGFLLQTLGGSPKLEWVRSLIEEERIPTHLGFEPGNVLANNLAVDLSVGLESLVSQPDLVGLFGNTVIKTPKDLLNEVFPIKEYDLSYIVEVLGLAGFPSVDLSLLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWZ5</accession>
    <name>A0A2T4BWZ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1338325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWZ5"/>
    <dbReference type="SMR" id="A0A2T4BWZ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BWZ5"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015687876" evidence="1">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="16"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="287" mass="31028" checksum="5274FED0F36BF4F8" modified="2018-07-18" version="1">MWSPKVAAAILAFVGLSDAWAPPSYGGFNLVWNDPFTGNSGTSPNTGNWNIITGNLNVNNELETYSSSTKNVQLSGGNTLQLVPWKDSSTFGGWTSGRIESKYTFTPQPGKVTRAEASIRMGSNAQANKQGIWPAFWMLGDVLRHGGSWPSCGEIDILEQVNGQPTGHGTLHCDVYPGGICNEGNGIGGPVNFNNPNDFHTWRVEIDRTSNNWQAETLTWSLDGTNFFQITGSRIGNQNVWNNIAHSPLYFILNVAVGGSWPGNPNGSTLDGYGAMMEVGYVAQYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXM8</accession>
    <name>A0A2T4BXM8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1338784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXM8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="546" mass="60379" checksum="9C23502125D9180C" modified="2018-07-18" version="1">MKKYFGLRGQALNWAIGTIAGCDFLLFGYDQGVMGGILTLPVFLNQFPDINPDAAVDASDASQRSTYQGIAVASYNLGCFIGAIITIFIGNPLGRRRMIFLGTAIMIIGAILQASAFTLEHFIIGRIITGLGNGGNTSTVPMWQSETCSAHKRGKLVMIEGALITGGIMVSYWIDLGLSFAPGSVAWRFPLAFQILFCIFILAFVLGLPESPRWLILKGREDEAKEVIAAIADVDIKDRHVENEFQAIKETAMEMSKGTYGELFARDHNRTLHRTLIAYVNQMFQQISGINLITYYAAKIYSDLGMTPFMSRLLAALNGTEYFIASWPAVFLVERVGRRKLMLFGAIGQAATMAILAGVNSVPNEKPFQIAGIVFLFVFNTFFAVGWLGMTWLYPAEITPLRTRAPANALSTSSNWIFNFLVVMITPVSFNSIKWKTYVVFAVINAFMVPCVYFFFPETAYRSLEEMDTIFQKVKGFRGAFDVIRQAEIEPRRYGKNGELLIPVDEVDEKAHAEHHNGSNSDGSNGGDANKSMFIGIDEESARKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXQ6</accession>
    <name>A0A2T4BXQ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1382284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXQ6"/>
    <dbReference type="STRING" id="983965.A0A2T4BXQ6"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="419" mass="46236" checksum="240F9BADD1D48564" modified="2018-07-18" version="1">MPEHDPLVLSYSHLAQFRRADEALTILKKVASLVKPIMRNRGWTVRELAEFYPNETNLLGLNVNRGMKICLRLRYPQDQNQFLATESIVDTMLHELCHIVHGPHDGKFHALWDQLRDEWQGLLFKGYTGEGFLSEGHRLGGRQALPLREVQRLARSAAEKRKAHEQLTRGSGRRLGGGDVSRPPRPGRNLRQAAAAAAEKRNKALQGCATDKLSDNEIRAIADTASRNGFRTQAEEDEANDLAIAQALWELAQEDEVANLGGGSYMNSSPAEKVMKGSNTTDSRRAAPASPPDGERFWICSICTLHNPPTFLCCGACGVERSEETLHAPVTPRQPGPRPAVIDLTSSPPRTKSYPRETRRTATAQPTAAAASASGQAKAPGQAPAPAPPPTWRCEYCATEMERQWWTCSTCGQMKFNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXR6</accession>
    <name>A0A2T4BXR6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1432296</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXR6"/>
    <dbReference type="STRING" id="983965.A0A2T4BXR6"/>
    <dbReference type="ESTHER" id="trilo-a0a2t4bxr6">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="91"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="469"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB74123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="739" mass="82314" checksum="D42919A50A05C5B5" modified="2018-07-18" version="1">MMAGNEAMESEDHIMGDTDMPNLNGHGGGEVQGNDDETASDSIYHEDSEPSVIEETIAQQRSRRRLLATGCCYDDRMKLHMNADFSPNTHHPEDPRRIHEIFKAFKKMGLVYTGPESELPQIMKNCPTKYMWRIPARSATREEICLAHSPEHLAWVENLGSISTAELRELTKKFDQGRESLYVGSMSYPAALLSVGGAIETCKSVVTGQVKNAFAVIRPPGHHAEFDQPMGFCFFNNVPVAVKVCQQDYPDQCRKVLILDWDVHHGNGTQNIFYQDPNVLYISIHVYQNGLFYPGKPPNPMTPDGGIEHCGTGPGLGKNINIGWHDQGMGDGEYMAAFQKIVMPIANEFNPDLVVISAGFDAADGDELGGCFVTPACYAHMTHMLMSLAAGKVAVCLEGGYNLQAISNSAVAVARTLMGEPPPKLVLPGINKDAARTLAKVQAYHAPYWECMRPGIVDVPEVQALNADRLHDVIRNAQRQVAQSKHSMIPLYIQRETISKSFENQVLVTPNLHEAKRILVILHDPPQLLAQVDAVDSTVDTHNAWVVDGVTEYIDWAVGQGFGIMDINVPHYVTREADIDAYIPRYNEKEIEEQIMSLVCYLWDNFLQLYDTNEIFLVGAGNAYLGVKVLLINRDCKEKIAGIVNFVTENLRPVKSDVDHDLSSWYKDNSRVYVAADHACWADAELTKKVKKRRFGTVVRSSVVGLNQMMHEHAAEAREWIMQRVASHPDGDTTEEDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXS1</accession>
    <name>A0A2T4BXS1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1058424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXS1"/>
    <dbReference type="STRING" id="983965.A0A2T4BXS1"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="462" mass="52598" checksum="CECB2AFEF69251F6" modified="2018-07-18" version="1">MVIYDPPRKTSRLHYLIPASQPNLQLCFNLVSSAVNRYPVPILLGWNGVDEFDAAKTHLAKLRAMQRYFDSLPPEEDDDLAIVVDGYDVLIQLPPDIMIERYFQLVERADNHLAQRLRVSVGELHQSGLRQTIFMGPDKICWPIDHRAPRCWAAPESPIPSAAWGEDKGYGEVFHSDPRWLNSGTIMGPVGDLKRYIAATMDEIQATYDSIYEFRESDQYYLSNVWGRQEYWRSKAMNDNIPAPPNGFLPLKQTPFQQTEYHVAIEYESGLFQTKAWYEPYFGYLQFSEPNLTARLAADIRGEGSAFEPPTIQMPDNVATSLGRLYDDISKAHPGLTSADWLSTVRLGVNFVTHHIYGVWHCTGSKQFIQLEYPAMWFFPFAKSLLMAAVKASQAGEPLTRKLINGRNWVSKKSYPALEGLGYGGVWTDLDDEFVPWRDVCQPHNRVLFRGEVEPKGRGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYA5</accession>
    <name>A0A2T4BYA5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1042859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYA5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8631" checksum="EAAD97203F599F04" modified="2018-07-18" version="1">MAQPVIISCSGWPRFRGGMIDQLELCARAFDDRGMPSPLRMVTASVCRRKDKSRGMAMRCGMRAHATVQGSKTQQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYG1</accession>
    <name>A0A2T4BYG1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1337645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYG1"/>
    <dbReference type="STRING" id="983965.A0A2T4BYG1"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="28794" checksum="9217940AFF869F85" modified="2018-07-18" version="1">MAELSMDAYWRAPPIARTVATVTLGLSVAVYMGILDGSLFVYDSRLILWIPPQLWRLVTCFLITFPNLGILFDTFHMYMYMSQLERGHPRLSRREDLVWYLTFICGTILILSHLSGFQFPQLTQALILAMAYTVTQEQRGQTTNYMFINIPSQLVPFAMMAINLFFPGGIGIVLLQLHGLAAAHLYLFLTKIWPEIGGGRNWLETPAFITTLVNGIAPGPPRPAVGGRVPDTASARSSGASRGPLPDSWRTRGPGHRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYV7</accession>
    <name>A0A2T4BYV7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1424215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYV7"/>
    <dbReference type="STRING" id="983965.A0A2T4BYV7"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="236" mass="26132" checksum="766782389E28CB16" modified="2018-07-18" version="1">MHSSFTRLQNVFGFFTTVAFVLGAFIAATDLGAPRTPSGVIKTDNVQVVKGRPHYYSPKKEEYAIIRFSLDADLSSLFTWNTKQLFVYVTADWTGPDNANNSAVIWDSIITNPSADHLQNLGPVAMKKLKRSAEGKSTAPERGLLKLKNQKPKYQITHPSGKIAETPDVTLRLHYNVQPWVGLLTWNMDKPFGVWKAMSGGVSDYFTLPALKTKDSKAKDAKEKAGAKSKTKSKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYZ2</accession>
    <name>A0A2T4BYZ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_66870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYZ2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYZ2"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044335391" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="174"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="282" mass="30046" checksum="8034B47D6F9907B4" modified="2018-07-18" version="1">MRFSVASTLLALASVASAASSWTFSDGTVQVTSKAGNDAVAKFSDIDRVQSTLTLGHQDKLKVTLTTKEGSKAKRPHQAFLVVKEASGLEAPFPLNVKESGKGTVEITQKDLPVQLLLSQEPLEASLVLGSFGSTKGSATPVFDFAVKLDPATAAPSYEKPLRYGKLAEIHHIFRADPKNPPKIVSIAFSLAVLATIPALFIGWFAIGGNFTHVQKALGSAPISHVVFFGSIVAMEGVFFLYYTKWNLFQTLPAIGAVGVAAFLSGTKALGEVQRRRLAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZA1</accession>
    <name>A0A2T4BZA1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1403163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZA1"/>
    <dbReference type="STRING" id="983965.A0A2T4BZA1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="105"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="302"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB74659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="484" mass="52940" checksum="66F7049CD28A0E57" modified="2018-07-18" version="1">MSDLASRITKPDEAAPAEKQPEVEAEAPVAEAQNDGAIEELGGSGLQEPEWDVEVSLSDLQNNEATPFHSATRWEDMGLSEDLLKGLLALKFLKPSKVQGKSLPLMLSDPPRNMMAQSQSGTGKTAAFVTAILSRVDFSNPEQPQALALAPSRELARQIEGVIKAIGRFIKPLKVAAAIPGALPRDQPVRSAVIVGTPGTVMDVIRRRQLDVSQLKVLVLDEADNMLDQQGMGDQCLRVKNMLPKSIQILLFSATFPDKVGSYAQKFAPNAHSLKLQRNELTVKGISQMFIDCADDNIKYDVLCKLYGLMTIGQSVIFVKTRESANEIQRRMVADGHKVSALHAAFDGNERDELLAKFRQGENKVLITTNVLARGIDVSTVSMVINYDIPMKGRGDSEPDAETYLHRIGRTGRFGRVGVSISFVYDKKSYDALSSIANTYGIDLVRLDTDDWDEAEERVKEVIKKNRAQAAYAPSATDNAAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZH9</accession>
    <name>A0A2T4BZH9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_56230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZH9"/>
    <dbReference type="STRING" id="983965.A0A2T4BZH9"/>
    <dbReference type="OrthoDB" id="4900361at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="99" mass="8777" checksum="C3E4A4A110584559" modified="2018-07-18" version="1" fragment="single">LAVTAAGIFVAAVPGIITGPIMGVAHLLGFTSSGVAAASVASGAQAGIGSVAAGSGFAVVQSAAAGGYGMAIITGIVQTVGGVAAAVGGVAGVVARAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C032</accession>
    <name>A0A2T4C032_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_6225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C032"/>
    <dbReference type="OrthoDB" id="4899520at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="237" mass="26276" checksum="3708A3F94D50D828" modified="2018-07-18" version="1">MPKVSRIKITRPTPGSPQAPGKRLKPIFNTPASQTPLYVDASPDPPAKKPDGMESRIKEHVSTAAKKLKTHLYTLEDILEADKKLERRDIKAVSREVKEGHERVEKRLDDIVKGLEKQLEVVQGLGPLMAETANKINAGKKRSASEAFETDEGERTSTGHDSSFKQLERRLGMQLGNTQAHIELVVCEMKAGMFKRLANLEEKIGAMEEKMDRMARFMAKWEAVSSASTGPSTVSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0B2</accession>
    <name>A0A2T4C0B2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1266767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0B2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="90" mass="9852" checksum="79B28F65F0F2BF68" modified="2018-07-18" version="1">MRPSSADAPWLTRPFPPALHRVFALHDDDLAVCLIMLSISRCCCRQPIASDLCLLLLLLLPIQLDGCSVGEFGEKSEEAPSPHNGSSHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0L4</accession>
    <name>A0A2T4C0L4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1335314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C0L4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015655974" evidence="3">
        <location>
            <begin position="18"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="916"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="1190"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="1315"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="1448"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1553" mass="164589" checksum="66289AA85305C6E6" modified="2018-07-18" version="1">MGLAALLLTAFVGLANGLASTDTITWGGDNSRAGYQTNHNMDPSVVGSSSFGQLFQTKLPGFYADAAEQIFSQPLVYTPSGGTKQFVYVATTQNNVYKLDAKTGDIIASRSLHIPFLAADLEGCVDINPSIGITATGVIDPETDTLYYTAKTYADQSKQNSPQGRDAGRYFIHALDVNDLSEKPNFPVPIDGVTARNNNVRMFTGGIHLQRTALLHTSQYIYAGFASHCVQYNFTGWIIGWDKATGKIVEHYAMEGKGVPNDVRGAGLWMSGGGIASDDAGSIWYATGNGYASQLANVPVKGFNPPTSLEEAAVHMTINDDGTLDLVDFFMPWEKQALDGADKDLGTSPLEILPSEFACGDVKRIGVVTGKSGKTYWLNLDNLGGYRNGPGNLDDVIQTYQNDNSVYAGAGVYPLEGGYIYINIIQHPSNVFKFSCTNGVASFTKVATTPETNAYVLGVSHGTTTSLNGQPGTGLLWVTDVQGLNLRIYDAVPKNGVLNMINSFNIPGVMKFTRPVFGNGIVYVGTNQGQFYAFGSPVKSPLNCTSPVAFGDISVKKSSESQEVQCTALIEVTVTGIALDSTKDYRIFSVPTTPLELAEGQSFTLRAKFSPTVVGLISNDIIVNTTNGVAGFSSSTHARLTGTGQSPGALLSVTPTTITFQSVVTGEDPDGVTETLILNNLGNEPLTIQSVVYSSTSGRGPWETWNGSGNLTVGKFTFQKLLSSLGPKGSTAIQVKFDGSSGGTFSAFVTFVSNGGNQTVSIAGSSGPAAVALLEFQRPDGSGWTKYANGTPFTFGNVTENNGRSLKFRITNAAPEGGVNLSLTVSKPPFGATGLIRAMNQIDLAEGTSLAPGESANATLTCTVPKSQWNVDPYNGTAQWTLNTNDPNLGKQFVQFFCRAVAEQAPPLLPNSDQGRYRYAGCFKEDNPGRQLSNQLYGADDNTNSLCISACAKNKYAYCGTQYHTECWGGNTIPKLRVDDSNCNYYCGGDINEVCGGNGDGTAAYISLFADSLQSGDGPTPHPPSGGPVVNPGVDGYASIGCYTEATDARALPNWAGTDEQTVAGCVSACKAGHYIYVGIEYGGECWCGDSFNDGSVPTPIAECGMTCNDNSTEYCGGPNRLNVYKLDTAIITTASISVSTATTTNPPEETLTTFATTTTLDTTTATAPITVSTGSPTPTGPVVNPGQHGYSSAGCYTEATDARALANYIETDKKTVGDCLETCSTSHYVYAGLEYGGECWCGDSLGKGSVPAPIEDCSMTCADKSTEVCGGSNRLNVYKMSKLPISTTTISSTATSAPSVPTPTGPAIKKYVRDYTFQGCWEEPLDARAIIEQMFADDSMTLETCADFCKEYTYFGAEYGRECYCGDVLIEGSKKAANQDDCSFPCAGNDGEFCGAGSRLELYRLRLNASTSSSPSSTVTSPAETTTSKPLASPTPTGPVIWQGNKNFTYYGCLSEPSAGKLMDNQVYNNDTTMTPHLCLFHCSEYKYAGVEYGQECWCGDSLNLSGWEGAVPGENVTSSGCNVLCPGNSTEYCGGGNRLQLYVKTTTFDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0V1</accession>
    <name>A0A2T4C0V1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1379257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0V1"/>
    <dbReference type="STRING" id="983965.A0A2T4C0V1"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000680">
        <property type="entry name" value="UTP7p Nucleolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="270" mass="30672" checksum="F4888B587D820ED6" modified="2018-07-18" version="1" fragment="single">MAAMDGETAAAKAPTARKNDAIVTHKPRTDMATRAEREKARRIRDANQAYGRGKQINTKQIKDKKLRRNLKQLEAKYQNAALRAKDAEILLENTSGFLEAEGELERTYKVQQDEIVANVAVETAKKRFELKLDQLGPYLCDYSRNGRELLLGGRKGHVATMDWREGKLGCEIQLGETVRDVKWLHNNQFFAVAQKKYVYIYDRNGVEIHCLRKHSEVTHMEFLPYHFLLATMNTGGVLKYQDTSTGQIVAELPSRLGPPTSLTHNPYNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Q6</accession>
    <name>A0A2T4C1Q6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1274807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Q6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="131" mass="15083" checksum="CCC5E6DCCF3836D8" modified="2018-07-18" version="1">MYFDTLPPRLVRPSTDSFSYTRTRTHQHRELQEKTHRRTSTSTLAVTLWAWCPERPSSKPLGPGSLPRTRLANQAQYPFVPANQHGLQYSLTACVPYARASHDLFRGRVWCRHCAAGQRPVQVRVRVSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C205</accession>
    <name>A0A2T4C205_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1356973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C205"/>
    <dbReference type="OrthoDB" id="4900088at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="225" mass="25733" checksum="F436C716AD0C8024" modified="2018-07-18" version="1">MASLQLNLPNAYFIDVLKQAITMDHVQFFLFELLAFVNVILWASIQRKLLLSLTEVLSGLRGNDADIGDDDRTTCSPELDDRGVEERREDTQSLIWIVIPLYLSMYGSAPAEPLLVGIAMRSIPLALSLRFYLEWPTVSQHLLMLWAKVWLGETVLWTKSAILLTVPILSACALVGNFLVLLGRRLRKTEHPEPPHPHILAETWRVSLPMLRDVLPMMWRDFFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2B3</accession>
    <name>A0A2T4C2B3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1258639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2B3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="17882" checksum="407A3F0D2DB5A54D" modified="2018-07-18" version="1">MIPTIAPKFGPLGHVVLQLKPKTGNANDQKMCFATMLLLSSNASRNEFCQRVWRSASISRGSSFSSSRTTGQKPTDRRLCADGPGGLPRPPERSGRFGSFDGGSDNRVWRFQCGANRDHTSTSLTREKHESSPPYLSPSHARSPGQTLRPCAFMCVRAAPSNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2C7</accession>
    <name>A0A2T4C2C7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2C7"/>
    <dbReference type="OrthoDB" id="5307331at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="815" mass="91193" checksum="2FBA8FA5A6BF9ECC" modified="2018-07-18" version="1">MSDPFNFQFTSGGDFTDSWQDDNTGTYDFHSNVFADPFNSDTAITQGNGMGIDLSLEWGMPDASINQFPNNSLHDNALFPSNNNQLLLPFNQQVQTQNLQQYLPLDQDSQDDPFSAYAPLDSINDTNSLPFGQQFLQQSNQALPLTTGNQFFSTSTFELAPDDHAQSDNNRRQSTASSETAALDAQKVSLNRAAKRRGDPSCDPSRRYTANLVNVSPWGSRKWNGKHLFGYTPKGQWLRDRCFNRKQLQEYVDNCAKETVFWVQQAPTQCNHRLDPEDRICRWANCPVANRTIAAGWLRVAFDEFPHLTSNGLRDPLKCAGSMHLWCFEQAFDPLQFHLSGRLRAEDREFPLEDKSVVTLEKLTDAGIIREAYQPWFLQRMRRPNQPPREYRDTLSYRLTRYHVDNQTAARQKARSKRNTAKSADERRTIDVHLGNLKLFVEITNKVKRSKKARKLQRARSEDDEESSTSSQAWANGEQMTAMSRYPEHTQGNLLSLPGLPSGNAHGKRMKTSHSNPLLNSSLGNGPLGYFDPLNPVRNAMQSSTETPLDTNLLQNSLTGFPSQNYAQMVTGARFNRATRGQPRQTPRPIITQNLQQISPSSTMIPSQAHAPQQPGRPSNRSNLSLASQPNVLLKREPLWTPVESLHSVGGRTGMGFFESQQRVNPPQQELEFCDFIDPRLFGDEPEVGQHHEAAVVEAKNDSAPDTISESIEVQPQGSLGGVVSPQAAAPSQYLNSLDDHMASAEFGVFDDDSSFPSLFEDLTSANGVNERATAPTGVISISSSEASDSKRKSLSHKYDTRSRQNSRTRRTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2F6</accession>
    <name>A0A2T4C2F6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1260296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2F6"/>
    <dbReference type="STRING" id="983965.A0A2T4C2F6"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="115"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="424" mass="48291" checksum="F3E5DAB33F14A2ED" modified="2018-07-18" version="1">MGLLFSGNGDGLASRLGTSPWVLYSVAGFTLYAALCSSLRFRRLKAMRKRLNYPDRESLSRMTNEDAQKIVQYLSLYEFPILYDFSLRYAIFKTYAIDNIGNLLYRVSDLARPTEASKRYDDTQVLFAGYVNFPPGSEALAMSVARTNFLHQPYRQCGKISNEDMLYVLFESMYEPVRWMRLYEWREMADMEVAALAMLWKYIGEMMEIDYKAELGKDQWKDGIDFMDDVAAWAAQYENKHLGPSPDIAKLGQVLVDLMLSAYPKFSRAPGYKILMVLMGERMRHAFGFPEPGIVESVIAYSLLLTRKLFIRYLCLPRIFPTTFISKPDPVTGRIKHYHYLKDPWYTPATFWARWGPEGLFRRACGLKVAGDGGAAMLPDGFLFEDVGPRDKMGKGVEETARLARAAQTKVSASACPFALPKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Z7</accession>
    <name>A0A2T4C2Z7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1357456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Z7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2Z7"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="128" mass="14376" checksum="CE88CDD3A743438C" modified="2018-07-18" version="1">MATMAAAFLPRLSSPLAFSVSRWANFYTTQYALKFLPSLSIAVPGVTINLPGLLGDIWESVLRAVPKNKVSHSKKRSRQMAGKALKDVNHLCKCPGCGEVKRTHRLCQNCLEEMKQIWRQDYPANKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Y4</accession>
    <name>A0A2T4C3Y4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1249332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Y4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="83" mass="8927" checksum="34CD900CAD47634C" modified="2018-07-18" version="1">MHPSGQRSSRGRIVAAVKTPLSLLIPFCLSVSEQGGNPNLSLSACPFCWQLHDWGAGKRRVAMKDWRTAAPPPTPGRSVIDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C407</accession>
    <name>A0A2T4C407_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C407"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="316" mass="34783" checksum="E8182D12DDAD0D8B" modified="2018-07-18" version="1">MATSSDSPIKILPNELLSNILSSLTTKELLSVVTVSHLFCSLATRILHRRLVSAASLPDNQAILECYHPSAKISTPYLACRYLGTAICGGHAIDEQNPRFQHLRKLYSCFRPVVMEENRRARFRYGWSSQTLAGSSQLQIAAEDEAVVDEAAHQEVYLDEGERFSQLCTVTNVVTQGSRPGLFTRHINISDGVIRVFRDWLASMLERPSSIRSGASSSSSSTPVAVTGDTLASSGVFSPDDSRVLWVDSTQDVGLRFRVLPGPEVRGTIFEDEPPVFYNLIYEELIVRTSTLLMAVEEAADQSMSHSGKDIIIAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C432</accession>
    <name>A0A2T4C432_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1333888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C432"/>
    <dbReference type="STRING" id="983965.A0A2T4C432"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000010">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="396" mass="42563" checksum="3EA5BEAE50C3F6E7" modified="2018-07-18" version="1">MGSTAFPPPPVNTIDWSNVGFRVREVNGHIESTYSLKTGTWTPLRFVADPYMRIHGMAPALNYGQQAYEGLKAFRMPGDASIAIFRPDRNALRMQHSAEVVCMPPVPADLFLRAVKAAVALNAGYVPPHETGAAMYIRPQIYGSSAQLGLSAPEEYTFAVFVIPTGVYHGSHPVRALVLDEFDRAAPNGTGHAKVGGNYAPVLRWSDKARGEGYGITLHLDSARHEDIDEFSTSGFIGVKTNDNDVTLVVPDSKCVIDSVTSNSVLELARSYGWKVEKRPIKYAELPSFSEVFAAGTAAALVPIRSITRRGTKGLADGPKVTRTDADGGAETVTYIPDGVEDAGPVCLKVLTALKGIQLGKVEDTFGWRFAVSEEDGKGIAGDGLGFDAQTVDEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4I1</accession>
    <name>A0A2T4C4I1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_66219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C4I1"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF261">
        <property type="entry name" value="BUD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="85"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1401" mass="156843" checksum="407D334710D7C6F6" modified="2018-07-18" version="1">MVRVTDELALSPEHVALYHASDPLLGQLPVLIFHGPSTTANYTLNSSRVQVHVFTPAGFQSFPRITISPTSPFYSVVNHLPREFQGDEVYRGLAFGLFRYFKELPDTVKAHLKATYPPKAKRPASAPALFSEQHAADLVKEMVKSENTVDVVATLEEALQTQHISNVDMDLILPPGSIVPPQASELEEMPDDEDDIIDPTLRQYGPYTPLVKLFGEPDPLGALAMAKLFLEWFPKFTQCYQDYIKASQHFPTLLNSFLDQQSSFRQRFSQTGEQTIRSLLIEPVQRLPRYSLLIDQIIASLPITHPALQPMLKARDIITNICSMDDPLPDKPHITNRLRNMVEAWPKDLEPQGRLILAADFLELSPPYQATVDSDDAGIFLLFSDCIVMLRKSGDNNMTGRDLLREIDKPSAAELLISMTNAAGGPSHYEFIFTGWHYLADVRFTESADGHLVWMTSSAEMKGMHPGEHKVPKAITSRCFLLQEAFEGKAAKWSEDVVKARIEARFPEAEREDSRWTLRSVRMPENNLGLHAAIFQEGADQLIEGRREPAFIRVVVDHEKGTKGAPVGHYGIEIVINVSSKNMKRISLLTVGLNGKQFQDDVALEDFLPTMSRRIMQLLSIQFNVSNRNLTAPLVSYHSKMLRTLCLSNRAEKTRSFLAASPVKLFTSLWSSGSNNASETTLSDTKHQHQASLHRADSHHSMYGSIRGKDSSRRPLEEVMPENPLVRLEQTFEAFTTALQYRKGSIHGRTLLHRAMADELLVNDLYNRLIENPQEVEVANDVGTEVVFTAFENFLHIAWADQIGPVTTIKMLDTLQERANKRVPGEFADFVNFLFKELAPQNRRAFTALIKLLADLLEGCSNDSDRGALTLAFAEMLVTDGTAANYINLLDRLVDDCDRIFGEPMYAGFSLADLALIESFQSRANGGGGNKSHQGSVTSNTSSLRRKFGLDMLLRQNSNNSKEERTSVWRSLGKHRHLATGESASMSRATMQQALRQRSIDDNNMQKRFTLGRPGSGDRPHVASAFEDPARPPSSHRMEFPLDTIGEPAHEPPTPGTPRRQYKRRSSLSDLKSLIDTASIEEDREGEERESALQPLQNTKETSEKVNGSPRTTMPASKMPMSPEQLRSPRLKENIATADLYGSVRMKAGTPIKEIQAKLEQAMRGNSPTRQDPPPYRRPKPTHSKTLSTSNIPTLLPPKPIRPGSSSGESPSRLSGSPTRTPAQKLRLQSPQKLRERLQTEKTAVGEADAVLQSELSKIGEEMARVNSDSYTDSPMIDLQRLASSVAALEDEMPAVMQELRDRQDELQRDVEITLKTTESKMRSIDQLHKEAVAENELLYERFNSELGKIVKALKGKGKEDKEELIVKLKTQGEELAKMKKENARLKREMISMRAALKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4L7</accession>
    <name>A0A2T4C4L7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1439163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4L7"/>
    <dbReference type="STRING" id="983965.A0A2T4C4L7"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="15821" checksum="62070F37DC937229" modified="2018-07-18" version="1">MGKPKRNVLAAAQEALTPPDALEPTQAIVRVLKPEGNNLYTCEMPSKKHVVLELAQRLRNTVWIKRGGYVLAEGYPVGTQDSRAFGEIIKVVRDEKLWRKQPYWPKEFEKTVEEVNDEESDSNVGKLPPSDDEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Y5</accession>
    <name>A0A2T4C4Y5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1230698</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Y5"/>
    <dbReference type="STRING" id="983965.A0A2T4C4Y5"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="564" mass="62514" checksum="DD288A36B86181B0" modified="2018-07-18" version="1">MGIINGIGLPRRIGRLVLFSGIVLTALVVYYLTSAGRVQPVFIPSSFDWSAVQQHHGVDDIKPLPTGKPAVLPRIQAEAGAFGHSAVNEKRRNAVRRAFKRSFDAYKKYAWMRDELTPVSGSAKDPFGGWAATLVDSLDTLWIMGFRNEFAEAAAAVGALDWSVTDSTAANMFETTIRHLGGLLSAYDLSGERVLLRKAIELGEMLYLGFDTPNRLPGFWLDFAKAKSGKLVAGTNDPSASPCSLSMEFTRLSQLTGDSKFYDATDRVTRFLERIQNDTLLPGMWPTTLNFQSETAVDSSFTLGALADSLYEYLPKMHALLGGVDDVYERLYRKAIDAAAKNLLFRPMLPDEDNILFSGEFSAGGGLSADSQHLTCFVGGMFALGGKLFDIDGHVDIGERLARGCGWAYSRFPTGIMPEIFGMVACKSLDTCPWDEERWDKEGGKTLPKGFTHARDKRYILRPEAIESLFVLYRVTGKADLQDIAWDMFESIMKATETELANSAIEDVTVLGPTKKLDSMESFWMAETLKYFYLIFSPPDVINLDEYVLNTEAHPLKRPAVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Z0</accession>
    <name>A0A2T4C4Z0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1430421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Z0"/>
    <dbReference type="STRING" id="983965.A0A2T4C4Z0"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="391" mass="43291" checksum="BD765B25FF6E4829" modified="2018-07-18" version="1">MSHAQDLSLPVIDPASPPDFQSPTKRIYQPDDVGRFLASTAYRDIGLFILQLNHAVCPRQPAGSSTPTIFPLGSKSTRTASIRSCQTLLFRIRDLIDKAPPAPGSQRFGNVSFRKWFALLQEELDTLLNDGLLGETLRIGNGHAKDEVASYLLGSFGSSQRLDYGTGHELNFVAFLGCLWKLGHFKDGIQGGDIEREIVLLVIQPYLEIVRQLITTYTLEPAGSHGVWGLDDHSFIPYIFGSAQLTRPINSEVEPMPTDGSVRGAPKPSDVTNASIVESMRQVNMYFSAVAFINDVKKGPFWEHSPMLFDISGIKDGWGKINKGMIKMFNAEVLSKFPVIQHFPFGSLFSWDENREALEHSIGAVVHPFTLLLQLGCRGSALPQPLFLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Z8</accession>
    <name>A0A2T4C6Z8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Z8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="62" mass="6729" checksum="25F07216090EE92F" modified="2018-07-18" version="1">MGRIDRGVRVCMSLVGVVGSFSLARRFFAAMAWHGMAMGMGLYHPIPIPPVPVLHPPSDPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7F4</accession>
    <name>A0A2T4C7F4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1214071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7F4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="180" mass="20391" checksum="B17B5753B431C175" modified="2018-07-18" version="1">MREAPGAGGALRDPIILPICCERRAVWRINSEYKCLARGRYSTKWMIQMLHRRGIAPLRRGSTSRAGGSPCRVAEYGFGCETLRTPLRVGQYSPVWSRMDSTPRYCEMLHTYGYLMRLAGLGIQSRPGNDERQSGQLIARGLSPPCQRRKTKRPARKLPALIEGSHDRRRAALAERPKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7R4</accession>
    <name>A0A2T4C7R4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1330261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7R4"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="425" mass="45824" checksum="289B1877D813BD20" modified="2018-07-18" version="1">MAGLQIWRHVPGKVLLFLINVVAATALIFEGYNQGVLGTVSATPGFIKMADIGHDGVVTNTTKQGGLAAAYYFGGMWGCFIGGWVGDRIGRKGGVLIGTAFGILGAGLMAGSTNASMFICARLLDAIVEANHHKRNDLANIVLGGRFSGKLHLGRRAVLGFALQWIQQWTGILAIVGWAGVLFELAGFDPYKALWLAGLANTFGVPGTAAAALVIDRMGRVKSLITSFAIQGVCLFLVAALIKTSQDNAISDPELSQRLGTAAASFVFIYVWFFTMFNIIPCWIYGTEIWPQEVRAKGYSFTIFGWATGCGSTTLIMPIFLSRAGYGTYLFFGAMNVVVAPLIWFFFPELANRTLEEISLLFTSESLLASENMKEYHRRVDEAGGNIAVAARQLLDEVDGKDAESGTEIGSPDEKRVEVNQDATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8G0</accession>
    <name>A0A2T4C8G0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1400740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8G0"/>
    <dbReference type="STRING" id="983965.A0A2T4C8G0"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="434" mass="47939" checksum="8409BDBE001FB9CA" modified="2018-07-18" version="1">MASQKRYGKLPPSANSEAIEPFTFNIPDAELTRLNTLLQLSTIAAENYENTYADKANQFGLTREWLVAAKDRWENGFDWRQREDLVNSFPNFKAAIPVPVDGSPSTTTTTINIHFTALFSSNPSAVPIVFLHGWPGSFFEFLPLLNLLRDKYPDEASLPYHVVVPSLPGYGLSDPPPKQRNFTTDDATWMMDHLLTKSLGFTAYVAQGGDVGAYVAHFLARGYPACKGLHLNFPAVPAPPDFAAEGLDDAEREGLQRNAAFGMTGASHALWHAVRPATAGLVIMASPLAMLAWLGEKFLYWTDPASFPNSPKDPEAPDGEKLPYSVRLMDEAIAESALYYLTGCASTSLYPYRDLMARGRSTVDGSSKLIAAPKIFGYSWFRRELMMAPKEWMAKVGNLVFYKRHDKGGHFAALEQPAALLEDVEEFASKLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8G1</accession>
    <name>A0A2T4C8G1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_65663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8G1"/>
    <dbReference type="STRING" id="983965.A0A2T4C8G1"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="671" mass="73342" checksum="8DBD1EDAE49C012E" modified="2018-07-18" version="1">MPQDMEDNGADVSDPVSENEEDSETLAKDDDERMADTMAANGSYDEKKKYDPKDPLRPRRKKARRACFACQRAHLTCGDERPCKRCIKRGLADACQDGVRKKAKYLHDAPPEALRPVLGPNFSPPPSAKANGQRHGSIHSDNVLTTASGDSFLSQGNPSFPVYPNVSQPPVMPDALHLNPQASPISPSFHGASAAGQAHMGGMLSGNAMDFNALFDPSNPALYNFDLEGLNFGSQYAGWEFGILNKMGLGAETPPRENSISQTPKTEASYAALFGSSNGSYDASMMGDYAGVDLGSNMYTQGNLQHGLPHAFAIAAGPNSLASPSTDATASPQAIMDGSPNPGAGFGGLQNMSGGPRLKPKQDKMLQSILGKRQRDSASIYASVKEPYPYVAGFHNMISVLRNRLPLSKLWKIAQSLGEIRPSFISCTKDLTREDLIFMEKCFQRTLVEFDDFLQHCCAPTIVCRRSGEVAAVNKEFAALTGWPKDVLLGKAPNRNIHLRSSDEGTDDGESISSSGHITPATKQQPMHGSSNNNVNNNGNITGSKPQPVFLGELLDDDSLVEFYRDFAQLAFEDSRGKVQRSGRLIKYRTQEMLEAKEMLGPQRHPRTGILSSRVTMIDSEHGISRIEKDGKVDCTYCWTIKRDVFDIPMMIIINFLPRYHPNQEPHQLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8H5</accession>
    <name>A0A2T4C8H5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1421611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8H5"/>
    <dbReference type="STRING" id="983965.A0A2T4C8H5"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="102"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="298"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="459" mass="48779" checksum="987638AB75386DDC" modified="2018-07-18" version="1">MTSKPNATVSSERTPLINGESASSNGLHHHIIGGHHPERSPVFQFFFDAKHTPGNDSDKLVIRSLAYTWHVTKVTLLSNYVNFLLIMVPIGIIAGRLGWSPTAVFTINFFAIIPLAAVLSFATEEISLKLGETLGGLLNATFGNAVELIVSIVALRDNQIQVVQSSMLGSILSNLLLVMGMCFLFGGLRHRGSTGNGTEQTFSAAVAQTTCSLMALSSASLVIPAALYGVLDQKDPSNGDRDHSILVLSRGTAIILLILYALYLVFQLRTHSNLFDPEDPVGPDGEEPEQPSMGPIAAAVVLVVVTVLVAVCADYLVGSIDSLVETTNISKAFIGLILIPIVGNAAEHVTAVVVALRNKMDLAMGVAIGSSIQIALGVTPFLVIVGWIIGREMTLHFETFETVAFAVSVLVVTYTVQDGKSNYLEGAMLLGLYIIIAVAFFATPGDFLDKATDLVTGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8R8</accession>
    <name>A0A2T4C8R8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APG6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1438369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8R8"/>
    <dbReference type="STRING" id="983965.A0A2T4C8R8"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="154"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="285"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="157"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="490" mass="54712" checksum="16D55271A98519E3" modified="2018-07-18" version="1">MHCQKCRQPLKLDSSLDDLNPAAYDLLVSATSSPQAAIKSPSAQPSALQAQEQSRKSLYDKVSQHAGAPTFKRYRGGQPRDNTMSFIYLTESQVGHPLPPQQQQKERAMIPPRRRASSTNGAPEDEPQADMGHDIDKINRLFEILSARSDIDHPVCVDCTELLVEGLQKKLDAASKERDAYVQHLKDVQSNQPSEEDIKAWNEALKKADKDKSAAMEELKKLEAEKDALDDEIWALEEESRQLDKEEENFWRERNAFAAKMAEFQAERDSVNAKYNNDSQLLEKLQRSNVYNDTFCISHDGSFATINGLRLGRLSNKPVDWPEVNAAWGHALLLLVTVADKLGYKFQGYDPVPLGSTSKIIRYETPNPASSRLGGRPLHAPPKKHVLELYSSGDMPLGLTFMHRKFDTAMVAFLELVRQLGVFVQQQTESTGVPLTLPYKIEGDKIGETSIKLGIAQDDGWTKACKLTLTCCKFLLAHASNVTSYARNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8S1</accession>
    <name>A0A2T4C8S1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1462463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8S1"/>
    <dbReference type="STRING" id="983965.A0A2T4C8S1"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="68"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="351" mass="37086" checksum="2B444BDA5CFD82B0" modified="2018-07-18" version="1">MAEEQKPVEVAAPVVKEETAPVVVEETPAVEAAPVAVVEDKPAEEAKPAEAEEAEAAKEEDKKEEEAKPVEEGFLGHKAQGASFPKNLIPSKTFFFFGNEAVETEVLAAYKKAEKHVEVAQHNIAWAAHTGKGLLFIGDKKAPHGVINLADATEPETDGSHKFHFSAKGNKHTFKANSAAERDNWVAQLKAKIAEAKELAATVTESEATTPLAVDVSSPATVPTETTEAAVTNGETKKDKEKRKSSLPFTFGKRDKSPGPGSEGEEKSGKGAFSKLRATIKGKGAAKPEDKPAEEAKEEEAIKEEEETPAAAATTEEASKEEAVVPKPEEAEAENKPEAAAAPAPVVTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8U4</accession>
    <name>A0A2T4C8U4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1400885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8U4"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33530" checksum="7246121ACB8AAEC9" modified="2018-07-18" version="1">MGAGRFFCVALPLLLTIGSIGTLLYAVLAGVAHENLKLIQVDLSELSVSPLSFKSLVSRAELDVKAIQTDNITAEALGLHKYYDLTLWGSCSSDDKKKWECSKSQFDWASKQINSSDITQGGTTIQLPKDVKDALKAFQKLIKWSEVAFIVALIGLGLELLIGIFSNFSRAVSCLTWFESLVTTILVIIACSLSTATVAIIAGVVQGSKTLYGAKVHLDGRFLAVIWIGAAFCIGASLFWIFTICCCKPEKRQKSPKHSSISDGEKLLPGGGFGSRGYAPLGENTGYTSSAPRFAAGSGRSDLAYEPYSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8X9</accession>
    <name>A0A2T4C8X9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I 3-dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1328624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8X9"/>
    <dbReference type="STRING" id="983965.A0A2T4C8X9"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="710" mass="77418" checksum="614D5AFA1E02618F" modified="2018-07-18" version="1">MAAVQQLLASPSPAPAPVSSQHINNGSAAANMEEPGAIDNDQVIIDSGLMKGAPQPGDSRIVVIIYGQGQEHVVSVFAEVLGKPVKLKRQFRDVDHDDEGFVIGLALEDAQRDVEDRDQQLLVAINAHCISPHSQLMAKPRTFFISTTFPDVRAALPNLDILTVGADAVEIRVDLLREPRGDGTFSDIPSLSYVGQQVMLLRQRTELPIIFTTRCTQENGKFPMDNPDLYYEYLYRAIQWGVEYIDVELWLPERIRKKLYEKRGNSRIMSAFHDFSGTFKWPSQYAEDVFARSKQYADIVKMIAIINDHNENFELEYFRSKIRAQYPDGPPLSAVNMGEIGQFSRTLNTVFSPITHPLLPIIAAPGQMSTAEINAALALLGQLPKKYFYGISSAAARSIAPRAPFYEKCFNELGLPHQFAVVERQHNNPAGIQAWCNQKDFGGAYLDPGLSYQTIMKHNPWFSTLRNGQGPTLSEAAQGIGIIDTIVVKSLSSSGSGGSTSTPPSLPPGGQPGLAPNTSLIFDNASWRGILSTLTRDLAPSAYFGRTAVVLALTADDAAAVFFALKALKIAKIYTVGFRTPSGLARNAPPIEQFISMESLQRARSVADNRAPFVIISALGRGKSNIVGMLLRVFGEAGPSGTSNSKKVFLNLAEAASQQKNDPVMVAEQSGFTAYDAADVAAFTTVESLRLLVGQNVPYSFVRLASGNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C915</accession>
    <name>A0A2T4C915_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1437059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C915"/>
    <dbReference type="STRING" id="983965.A0A2T4C915"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="285" mass="32315" checksum="B4BAC9F645E39FF7" modified="2018-07-18" version="1">MGATQPKVLLFDIGGVCVKSPFQIILDYELSLGIPPGWINYAISKSGPAGSWQRIERGEIPLDDAFFEGFTRDLHVQQLWEDFYTAQQAKKDSRPVTEIPPLPRIDGKWLFNEMMAGAVAPDPWMYPALQKLRASGRYILAALSNTVIFPPGHRLHREDFFDEPVRQIFDLFISSAHVGLRKPDPEIYRLALEKLNAFAKENAHDPRHRGKGWEDGIAPKDIVFLDDIGENLKEARRQGFRTIKVHLGRTYEAVEELEKITGLSLEGPHPKIPIKPNYGKPRAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C925</accession>
    <name>A0A2T4C925_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1468617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C925"/>
    <dbReference type="OrthoDB" id="447346at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF2">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17471" checksum="09C3F2AEA29CE3FF" modified="2018-07-18" version="1">MSSTEATMDHLYALISPTQESYGQMCWLALPVIDIERAVAFYSQIFPWDISPNGVLHQRPGVKELYFFNSGDTLHGAFYVMEDGFHVINHSIDFQDGLSVHPSFNVRNCKETLELVEKLGGKTQLHKTDLGGDMGHYARFIDTEDNMIGIWSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C958</accession>
    <name>A0A2T4C958_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1329719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C958"/>
    <dbReference type="STRING" id="983965.A0A2T4C958"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="60"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="233" mass="26428" checksum="93F2FFE30A290529" modified="2018-07-18" version="1">MAFFHPHTFYHPTESSSSSSAASFTPLFRLLDDYDTYSRQTGKSSPASTTTAPTRRQQQQQVPQWQPKFDVREVESAYELFGELPGVNKEAVYIEFSDPQTLLIRGRSERTYTAGTSPTQSTKNVTDKAEEATSSRRNSYKATVEDEDEASERESGYEVVTTSEDNKKKSEEKKPVDKAKYWLTERSIGEFSRSFHFPTLVDHEAVSASFRNGILSIVVPKAKKHEAHRIQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9V5</accession>
    <name>A0A2T4C9V5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1190825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9V5"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="2">
        <location>
            <begin position="34"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="217" mass="24270" checksum="4080C1A0B691A46D" modified="2018-07-18" version="1">MSATQQHPDLTPLKPSFTPSPSSSTEEPPSVSFTIKVLSLAEHIEGGYYAVTHVNPTTIPSPYPQSPLSQQTIDLVGGLPPDFDPKFRRLSTTIYYYLTPNRPLGSFHRNRSRIIHTLHRGRGRYVLIHPDGRIESFVVGPNIDKGEKLQWVVEGGSWKASFLLPDVDGETSSDGLLISETVVPGFEYADHEFLSRERLAEILPEEKAKALEWLVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAG8</accession>
    <name>A0A2T4CAG8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1328714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAG8"/>
    <dbReference type="STRING" id="983965.A0A2T4CAG8"/>
    <dbReference type="OrthoDB" id="5221663at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="344" mass="38991" checksum="C21F61FD1EB09D6D" modified="2018-07-18" version="1">MGVFDSVGTLLADIANLISDGQRILSFSDKRHWGQDEREQERALDAVLDEARKDFQELGPLVNGRSQYEHDRKHDSIEELRAIRAKFQALTDKLKDWSRSGGPIDPTWVRETQSLKRELHRAQCRAAMRVFTSAREASQLCLGAYIVQRQQRAPLRNSRTGDKPDEGSYQRYYAEELLACKSVGTFQRFGEQDIAFVCDFCDGHLVWEDLERMPTLRTSTQATPPGSSNAPVSLLPNASNWQATGVTHCGQHQKQVIFAPVAIANHIVPRHGDWEARLRCPLCEAIGEQPQDEDDDDEAYRPDDEFDDVKSLQEHLEWQHGPSKLPIPIPLPTSTTTESNCRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAX5</accession>
    <name>A0A2T4CAX5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1352403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAX5"/>
    <dbReference type="STRING" id="983965.A0A2T4CAX5"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="585" mass="66618" checksum="58FF75121BA4BF0D" modified="2018-07-18" version="1">MSGFEIAGIVLGAFPIAISALEAYRDVAQRLGRFHTIRLEYKKWQDDLQFYKVAFTRNLKQLLLPLVPDDERLSELLLEPGGDCWKENSIAKAFENRLQECYPLYMQYIQNLKRTLDEINQELAIDSQWANKLLDSSPTPSMRAKLKGLISREGLALQLYKFKLSNSDGIRKRLFDELKEYNDKLEKLLRSSDEDTRLRSNRQSRQRLENVDITICGFWKKAKSVFQALANAWTCQCQQHGARLLLQHRTEWNAEFEVMLTGFSPPRLGFHKIRVSEGGDMVAAKLKESVTLIESMPPRQPSHKQNRPLRSALKPNRGKQASQHLYRSSPSVTLTCVNTVPPLNFPGQISNLCTTFGLPESSCYGYLIDEDCRYYVFSVPQPGSEAMATVTLDQILRGELHLELTRMQRYTLSLTIASTYLQLLGSPWLPTMPRRVDISFHDAIEKTPAISLDEPHITQHFTGSHTDDGLAAADKHSRFAALYHLGIMLLELCFGRLIEDRLRRTGRPVRENGSEEAVHDIFLAALEWLGDVNDEAGPAYADAVSWCLTGNRCAAEKKWRQDMLDKVIQPLKLSRDFLVDGGIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBF2</accession>
    <name>A0A2T4CBF2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1352804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBF2"/>
    <dbReference type="STRING" id="983965.A0A2T4CBF2"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="599" mass="66284" checksum="FF6D05F6FFE2A758" modified="2018-07-18" version="1">MPSFWRRPFRHGEEPPVIEAEERGSTESDPSEIAAGDTYYIAGKGANSKETTYQDASGAPVEESSPLGYDVGPLTILFLNVSKMIGTGIFSTPSSILAGTGSIGLSLIWWALGFLTSITAFAVYLEFTAYFPSRSGAEVVYLEQAFPRPRWLFSTAFAFQSVILSFSSANSYVLAQYLYKMTDHNPTDWQLKGVAIAGYTVALLVVVLHNKLAYHLANGIAFVKIATLVFISITGFVVLGGHTRVQDPTANFHNSFEGKATAYGITNGLYKIIFSYAGYENAFNVVNEVKNPVKHIRRQGYIAIWSVSILYILTVIAYYAAIPKADIISGKLTVANLFFLNVFGDSKQVKALNLLIAISAFGNLVAVMIGTSRIIRECGRQGVLPWPKFWVSTYPLGTALGPYLFKYAITLIMILAPPAGDAFNFVSDLRIYPGSFFDFLMCVGLLIVRRKRKALNLPRPEFKAWDIVIWFSILKNLYLLIMPWYPPAGGATGGDVSFWYGTYVVTSIGIILACVAYYWLWIHGIPYFRGYKIREEVVTLDDGSKSHQLVKVPNAEVEEWDRTHDHAGRRITEAAESSEKTTSKVLVDGKDDTVPSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBZ3</accession>
    <name>A0A2T4CBZ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1370704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBZ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CBZ3"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="4">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="3">
        <location>
            <begin position="320"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="86565" checksum="41D6133B968A29D8" modified="2018-07-18" version="1">MGVSAISDLETVHKLEYLVSDLTTSSVTLFPSRAQVHRDIKGVQLKRGTNEVTIVGLSQTVDPDSIKVETNGTATITNLEVDSVPNRQRFDEVYPESDSESDSESESDEESSGDEARAEDHELRSAHEHLQELTDALARATDDAGNAQRRLDMLQEVGSLRERKNDDLLQAILEQYQVERSKAFEDLLRSNSLRRERSKDVAKAEKKVNKLQRAHDKRNAKEDKARARARKEKEKKKALKERLKAEARRERQRLREEQQEFWPLEVYSVRITLEVAAMTPMTSRRGSMSSDVDIVQIPSAPPVEGGDEEEEATSPIECNLAFSYVTASAYWTPSYDLQLSTTNASASLYFDAMLTNKTSEAWKSCKVTLSTSQATFSGLYDTIPKLNPWRIKLAAKGQHYHPSGDITRSAEEASYAISNTQQMQMMLQQQNIKRKKMVRSSAVPAPPPPPPAASMAAPRASGLFGPAAFGPPGAAPAAAPRGGGLFGSSGGGGFGSAALNAAQQQALQQQAQQQALQQQQQQQQQQQQSQNVLNDFDFDSFLHDDNAQPADGYDASLVEETGLTTTYDLPGLKTLVPKNNGSKQRVARIPFSNVAFSHTVVPKYKPVAYLKAKLRNGSKMALLKGGASLTLDGTFMGKTSLPRCSSGESFSLSLGVDPAIKVTYAKPEVRRTTAGLFGNQDSSVYVRTMTLHNTRAVGGRAVSLFVLDQVPVSEDEKLRVELSYPRGLAVDGAGVPTGEAAKEGKDDGWGKAVARLKKEGLVSWDVTLNAGKAVKLSLEYVVSLPSGETAQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCB2</accession>
    <name>A0A2T4CCB2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCB2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="23194" checksum="FEAB3A7AD81E7397" modified="2018-07-18" version="1">MYKTNEGPSAFEDAQSTTILPPRIPDPDESLQQTEADDAEAQYGDRIAPLGPMQRQRASNWLAGHGSLPDADSITATEDGFGSPSIVSSLHKECMRIYGPPGMLAQTRGRRQMRLFPLGLLELSVVPCSLLRTQKRGLTGEKGDDALGRYVSPAALWCCTARGASKRFEATNNSTGGAATAKNCALYGVKRTAQQEPWQSDKAPVTPRVDMRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCR3</accession>
    <name>A0A2T4CCR3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCR3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="18533" checksum="1BB01B63B408B1AB" modified="2018-07-18" version="1">MDGGFRSGQAAHVLDSRSGTLNHERRRNSPSPASIDFSHGLALQQGLEEELFAGSILRYTDGKAKLAKRKKDSKPMKPLLVCSWTFCVYEDRSSRPLQPVSRQVAKSCQPPTVQRLGGGAITTSCRDGVGVFNRVKSSGGKSPLGLARLGDSGGAGWLATTNDGAARFELKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCU7</accession>
    <name>A0A2T4CCU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mak10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1398679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCU7"/>
    <dbReference type="STRING" id="983965.A0A2T4CCU7"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="54"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="335"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="760" mass="85494" checksum="8296F18B206594EF" modified="2018-07-18" version="1">MADFGVGVPDEIARLSLGRGSSPAETLAPSIKCEGIIAVDITAKFSDAVKTLEPGAIVKDGFFTLFDSVAALEIMDPKMDSGCAAAEAEVEQLYDVSRPLLPEEVLGIIDQLLCHEMSWHLGYPLSQTLFTSFYVEALSTPDPRSIQEATFIRGGGHDPNEQPMLQVLRAYCLGMLKSCGYVNERIKSEHYYEEEDFVTNTYNRTLLASLPTSAIQDVLLEAMAALKSQRSSISDDLVEALLLRLKLRHIFLDAVECPKHMKEPDLAKTPWREGLAILPALKKSHNLASPVDEAFSAKLQRKLASTMPPRPIVQLDFDVAFGHLKGLFEDALELINVLHYTDSQCLLTFVTTFQAKKPQPIVYVRTLLQTFLFDAMEVLGSMSIRQLLDDDFAILTMPAHQYLDRLNDEVEAVQDPRYAMAQQMELFRTRAAQPFLDILRTACQNRCRVRRTLCHLLRDWEALQLDAEEIDQILQVKAKEQPTVYRSSMGSGGVESYSLPLSSWTYLYKLRQMEQIIQLGFELEIYQADELAGMYWYLNYISKSRLHHTERIKMFVIKRVEEAQAQPSAPSDPSVGAQLQRSLMYTRLSLLDAAVTWELSDSLSCLYTVLNRLKLVKAPPRPYGTDELRYEIRMRPFAPVGLPVLPTFEEFTTGTTQPDTEVEELFEYAERAVEGAKRGFEALSRMTAEESFSVGSHQRWAEAAKNGLKSCIATKIAIAAVQKAVAKAEDPENLKIRVEIPTPQKAYHAFWIVPKIVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD57</accession>
    <name>A0A2T4CD57_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1389491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD57"/>
    <dbReference type="STRING" id="983965.A0A2T4CD57"/>
    <dbReference type="OrthoDB" id="5334391at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="97"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="159"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="910" mass="100227" checksum="132C26D79AA97D0F" modified="2018-07-18" version="1">MRRLLSASASASSRGLSSASSPRTALALRPTRMSSSSSSPSSPRALSLTAARRLHATAQQLKPMDALASTATSFPTTHDPIPAAEVRNTPYFLDNKFVESKTDRFIDLHDPATNSLVTRVPQMTTAEMRAVVESSQRAFQAWKNTTVLFRQQIMFRYQSNEYGNGVAIFTKSGATAETFRKNIEAGQVGINVPIPVPLPMFSFTGNKKSIAGGGANTFYGRPGINFYTQLKTVTALWQSADAVAKKAAVHMPTLQKLSVVYLPYTIFTTIITTHLTPSQTILCRRLSRAFLAALTRSDLCISLILTHFPRSLEGRRLRAYLKSNNLDALEGGDWAAVFARLARRYFHLGNALPWKVEKVKVLKDEDGEGVLRGVAPWNRHLSLNGKTAAFHFWDPVWTVAPVEGLLVYPAPLREEDYDASCVNGGGEGGGGVRYRARDLQTGKEVDVPFDLRGKIVRRVRVSHGVLVFEWCEQKEELLSHDETTGRVYRHYATVYSVRRRGAWDGVIPQRGGGDGSSSEMPWPAAYTWEFELRCEFAIHPVGFALDHQDRFFSTHNATHYAVYTWQPRSPASGSQENGGGGPLESLTIWEFFNPPTSDTTTTPEPQSPRIIRTMSTLDLHHSAIRQGTAPALRAMALDDCTWDHSTSSPCGHLFITEEEHRWSAGPQSSSNPPRLHRVKTTGIPLVGEGPRWVDDCGGGGGVNLRFCWRGRWRRAMTEEAEDGVMLPHDDDGSGGGEEEDHVSSAERAWSRSQTWPGRAPCWRHDDFPYVTLSEVFDAAAGVRVIARDCFMLETLSVHIRPRIRVQGVGPDGEKVVSRRVSSGTATTTLASTTTTNHEPFSQQQTQIAAAGKNTAAGGKTSTTTTEGPDGHEVQFADALWSEMMGKGFICGDERWLVGEDTKGDVTILVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDY4</accession>
    <name>A0A2T4CDY4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1325939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDY4"/>
    <dbReference type="STRING" id="983965.A0A2T4CDY4"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="98"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="254"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1171" mass="135778" checksum="7BE0C6030D8EA27D" modified="2018-07-18" version="1">MQSDDEAYQPGLPYRPRANVTRKQSYNVPSPNEMVVDTDDYVGVPNAPEKESVTMISPEGGAEQEADQLQDLPLANDYDAMREVVLPPLLDEPKILEDYQHTWTVENWRSLGKRERGPIFHAGGYPWRILLFPHGNNTDQCSIYLEHGFEPDQIPENWSCCVQFGLVLWNPNDPSLYVNHAAHHRFTKEEGDWGFTRFVEIRRMFNVPWEGDSRPLVENDTANITAYVRFVEDETGVLWHNFTNYDSKKETGYVGLKNQGATCYLNSLLQSLYFTNAFRKAIYEIPTENDENMQNSAYALQRLFYQLQTSDQAVGTNELTKSFGWETRHIFEQQDVQELSRKLMERMEEKMKGTKAENVLPELFSGKIKTYISCINVPYESKRIEDFWDIQLNVSGNKNLLESFQDYIQVEKMDGENQYFAGDEYKLQDANKGVIFCSFPDVLNLQLKRFEYDIQRDMMMKINDRYEFPEVFDASPYLMEEADRSEPWIYQLHGVLVHSGDLNAGHYYAFIKPTKDGWFYKYDDDKVTKATLREVLEENFGGEYRPPHGYPRAPLQKKAPIMRQNSAYMLVYIRQSRLDKVLCPVTKEDTPALLRERFEEENALREARRREQKEAHLYMMAKVITNETFAKYGGTDLCVFDANPEVDPAAPKVYRIRRATPMSEFVAQVASDMGQDPSRVRLWLMVNRQNKTIRPDQPIMDLRPTVEEVFSRSAAHRDTSLRVWAEVANEVNENGEPVWPSYQSQPNGVVVKNDTILLLLKHFDVEKQTLEGVGHIYISKEKKVDDLVPMILQKMGWGDKLSSDEKLLMWETLKAAELQDGDIICFQRTSDKNGRVSDKAPQEANKWSDRVEDAREYYDFLEHKRTIKFHAHPTRSDPAQYPPFELVLNSKITYDVLVERVGAHLQAPSTHIRLWTVNASTNNPKTPVRRGTNPMLRQILSPMGSNTLNVTQRNDAFYFEVLEMSLAELDTKKNIKVTWLSEGITKEEQFDLLVSKTGTIEDLIQALVKKAKIPDEAEGGRIRVYETSSNRFYREPARDSPVMNLNEYTQIFAERIPEEEKAADENNFIHVFHFQNEVNRVHGVPFKFLLVEGEKFADTKKRLEKRTGIKGKSFEKIKFAIARRANYSKPQYLNDDDELWNIASSEDDYLGFDHPDRSRSLRNGVGDLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE22</accession>
    <name>A0A2T4CE22_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartokinase</fullName>
            <ecNumber evidence="9">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1325853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE22"/>
    <dbReference type="STRING" id="983965.A0A2T4CE22"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="450"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB79803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="513" mass="55803" checksum="20ED5650F8BA22CA" modified="2018-07-18" version="1">MGSSACDNSSEKGWVVQKFGGTSVGKFPDKIARDIVRASLSDHRVVVVCSARSTGKKAEGTTSRLLAVFNKLKNIATPISSEEKQHELIEQAAGLIRDVCNDHVAASETFVKDPELRADLVAKLKAECQELIEYIMATKRFNLEVNSRSKDRVISFGEKLSCLFMTTLLQDFGVEAEYVDLSDVLHSDTPSPSLDAGFYKLAVSRFVKKLAACENRVPVVTGFFGNVPGSLIDGDIGRGYTDLCAALCAVGLSATELQIWKEVDGIFTADPSKVPTARLLGSITPSEAAELTFYGSEVIHHLTMDQVIRAHPPIPIRIKNVKNPRGNGTLVVPDPVLSPGQRLHRSRSSQRAARDSKNPKRPTAVTIKDQISVINVHSNKRSISHGFFARVFSILDKQSISVDLISTSEVHVSLAIHADGIRSEAFETATRNLEECGDVSILTDMAILSLVGADMKNMVGVAGRMFSTLGEHNINLEMISQGASEINISCVIDARDATRAMNVLHTHLFTFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEU1</accession>
    <name>A0A2T4CEU1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1110721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEU1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="73" mass="7918" checksum="D477473B31D87DCA" modified="2018-07-18" version="1">MKNMKSSVCLFFCLCLALLPDVLCLFVCFLVYPLPLRTSRRLLRALAVTPQVLGLGVKKKCASLALALGCVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEX5</accession>
    <name>A0A2T4CEX5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEX5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015749292" evidence="1">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="53" mass="5638" checksum="722F05C957F6977E" modified="2018-07-18" version="1">MAHLIPHCSLGLFLSHGSFFFFSLPSPFSHCPTALLYGESVAVGQSGRSPNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFB2</accession>
    <name>A0A2T4CFB2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumble-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1435893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFB2"/>
    <dbReference type="STRING" id="983965.A0A2T4CFB2"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="435" mass="48059" checksum="8407B3BB34F5C4CD" modified="2018-07-18" version="1">MTSTEDIDNTITRPGSVRINVTGAFIVDPDASTPPQTSDNGRVSPSHHETSDIRLPNHTAIVSHIAVDIGGSLVKLVYFSREVDSTDPGGRLNFQYFETDRIDDCIEFMKLLRDKHKALNGSRSQELCVMATGGGAYKFYDRIREELEVEVLREDEMECLIVGLDFFITEIPREVFTYSEADPMHFVSPREVIYPYLLVNIGSGVSMLKVTGPRSFQRVGGTSLGGGTLWGLLSLLTGARSFDDMLAEAEHGDNTKVDMMVGDIYGADYSKIGLKSTAIASSFGKVFRMKLQSEAAQAAAAAAGDSGHDDTQHSHSFSSADISRSLLYAVSNNIGQIAYLQSQIHNLSDIYFGGSFIRGHRQTMNTLSYAIKFWSKGEKQAYFLRHEGYLGAVGAFLKRQPANWGRRASLEGADDIQEWRRTLRTGSRDESTTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFR3</accession>
    <name>A0A2T4CFR3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1348313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFR3"/>
    <dbReference type="STRING" id="983965.A0A2T4CFR3"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="489" mass="55003" checksum="AF6E44D2006CC0AB" modified="2018-07-18" version="1">MTSLPDAEADDESTQPFSSPGSNERLLYSRWHWRLCLWDGGHVVERMESFAGLILLPYLPCSRTSSLHHWFVQVLTLDSPSCEYQPPNHAAPPTREPSHGVEAGGGSFTVGGEQADKISCLKNTVSWRDVNDQARRSDHINFDVYSDASTNTAFFKLYCDFRFKGNNVEPIFLLIHPETVRSVTFKSNVDLPAPSALQFSLTQPPLLIVPRDRILQCKPQTKGLFGLMRSLAEVASFTIQLNKSSKTTSILSSLERFVQLFSVSTHRPLTNGTYASIASLYGGRGGIVVNANAAAATQSEPEETGEAVEAGEARLPKYTESASGKSSLKRQRKDSSPSRPRSPAPHERMLLLLESMYTSISRMESRLDSMEGRLHGMEGRFGQLDSRLGESNYTPCRYNTEERTDFFEEIHEQVEDRTLEMKLECEEMLKEVEKDTERAIEELQEEVKETLEQLEESVEENTERLVKQGLRTKLENASLRFDGTVFLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFR5</accession>
    <name>A0A2T4CFR5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1397731</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFR5"/>
    <dbReference type="STRING" id="983965.A0A2T4CFR5"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001147">
        <property type="entry name" value="Pre-rRNA-processing protein esf-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="119"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB80378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="319" mass="35989" checksum="9B5A00985FDEAAB7" modified="2018-07-18" version="1">MASTKATDFLDVSDSEDERLNTYDSDDEVKKGGRGPKRRKISSDDEDDDAELSEEEQDGSDEEKETSKQKKEDGDSAKTDEDSGKKKAKKLRTKDLPGVARPLTKKNLVATDEAIRKSGVVYISRVPPFMKPNKLRSLLSPYGTINRIFLAPEDPIARARRIKGGGNKKKTFTEGWVEFVKKKDAKAVCELLNARPIGGKKGSYYHDDIWNLLYLKGFKWHNLTEQIAAEDAERSSRMRAEISKTTRENKLFVRNVERAKMLDGMESKAKAKKRKASDASESEKPKGAVRTFKQIPKITKTEDATAEPERVNRVLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFY9</accession>
    <name>A0A2T4CFY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_196005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFY9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="16833" checksum="0A2AC219B87CEE74" modified="2018-07-18" version="1">MTNLPRYVPQMSGAAITVGNAPRLKRALISATPSLALTRQSYLYRYNHAYIYQRGSKPLAPPTAKISIRRTDALLVRVEIADSVRTDFGAVVVVALLRLLLLVRIQASQELQPTNASSNCHELFIALPVPQLQVAGLGLGHSSIHSLNASKHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGG2</accession>
    <name>A0A2T4CGG2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1132025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGG2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="19127" checksum="A46AE516E98FBC5B" modified="2018-07-18" version="1">MMQRYPRIMRSEELLRLDIQSNDGQLDTTRRYGAPEAHTHNNRHLVGGTVLCHLGWWKPRFWGWRLSRRGRSVWPGTRRETSSLRSYRWANGRDSWFFSLSLHYLCQRAGRGAILFVRCELGFIALGYYKRTLGYAGRLGLGSYWVGSSSICYYSTVRQYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGG5</accession>
    <name>A0A2T4CGG5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGG5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="9257" checksum="668B5D3B63A87A84" modified="2018-07-18" version="1">METKFPVPVRSFLLYMLLLPRAVALFQVYSLLNTAQLPKLQRSSPLTIRRVHFSQSGLFDSSSLDILRLEIFASFALWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGK2</accession>
    <name>A0A2T4CGK2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1419207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGK2"/>
    <dbReference type="STRING" id="983965.A0A2T4CGK2"/>
    <dbReference type="OrthoDB" id="5421909at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF20">
        <property type="entry name" value="PHYTOCYANIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015413202" description="Cupredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="21585" checksum="08EAB309C5F3FB41" modified="2018-07-18" version="1">MPSLKSLVSTIALAYLANAKTIKITATSDNTFDPSTVKASDGDILEFVFEPKNHSVVAGDYRYPCSPLELGTGFFSGFFPTSSGEADKVFRVEVNGTDPIAFYSSQGNECASGMVGIVNPSANQTLADYKKRASALARSVTPGRKPYGGDIADNDSSDDDDDDDSKGGKSGSGSDSSGDSSSDKDGKDSGSVSLSVSLGALGLAFLMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGS2</accession>
    <name>A0A2T4CGS2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotically up-regulated gene 154 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1398096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGS2"/>
    <dbReference type="STRING" id="983965.A0A2T4CGS2"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="51662" checksum="3B0CF80F8E05D919" modified="2018-07-18" version="1">MPRLVRRRSLWERITSMLNPMDFLLWLSEELETRDWDSKLVGTQLGMGMNLAFLVARANSGASSEWSDGDIFGDEANSGLLSYVTFPIVWGLVLFSFVNAAYAMTRTRKYRLFEANIEQAPSTPSARRVQLQSSPATTSSPLRYLTDKITSDSAESRAHPDKKRDVWELAVWDPLPISLRLVCLFSPGHVLAYLMFLPLEPLDPQPSVTVFNTIVLQVVLSGQMLFLSSRFAQQAKDNAIIQKEVLNEYNTKFVHPRLHPVVRDVGTQVAAEHSAKGRGFVEVGAPTTLIRKSYATRATSHADSFATPFTSRVNAMRPQSFSSTVPRHAEPTPTHLDQPRSTSTFRQNMMADPMSTPTPAPAAATAPVPLSATSANTTNFGGNMGIYSHNKSPLKKSFGLGTFDAAASPRNSREMAALEQQRHLAQAGSPTKNADSHRPSSINSRGVSTPYSSTTPHRATQQDRSIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH69</accession>
    <name>A0A2T4CH69_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1417691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH69"/>
    <dbReference type="STRING" id="983965.A0A2T4CH69"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000242">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000273">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF42">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="248"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="345"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="403" mass="42307" checksum="82B5B9AD840A4A0B" modified="2018-07-18" version="1" fragment="single">RTFADQGGKTPAQIWAEKKAREGGSIGSVPTPAAPSQAAQQTGGSSWKSGYTGKSWAPVQTGGATRGAGDSADQQEPEEARQAAEEEGSAPSGVSALRDRFKNTAPIGAGAPPPPTRAVEEEHHAPPPVPDSSRPTGGFALPGLPSRPAPAGEEEEEEEDPTAYQPVEERSPSPIRVAAPIPRGPEPVVERPEDRAPPPVPVEQVPVPREEELQDEHEAGHLARAAAGAVAEQTFEHAAHAADRDDQQGGKRALVQYDYEKAEDNEIDLVEGEYVTNIDMVDDDWWMGTNARGESGLFPSNYVELVEGGDAAPAPPAAPVAAREPEPAPAPVAPAAAPAAPASAAAGPTATALYDYEAAEDNELSFPEDATITNLAFPDEDWWFGHYGGHSGLFPANYVKLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI54</accession>
    <name>A0A2T4CI54_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_45125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI54"/>
    <dbReference type="STRING" id="983965.A0A2T4CI54"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="104"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="794"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="936" mass="100921" checksum="38669F0974CEED7C" modified="2018-07-18" version="1">MPLPPLPNGRNGPPPTATSPATPILTAAQVISLTREAMRHALENESQAVDVGPGLKSGVTIDLSRKGIQKLPEEVVDIVKNELERLALSHNQLSSLPARFAECVSLRYLNIRGNQIKEFPMPLCELKSLEILDLGRNQLRVLPPDIARLSSLKVLSIPKNQIRELPVCLAEMASLQVLKFEGNPISFPPRDALQIQSPSPSGEGSGREGEVTEVAITAHIKKFMKLHLINGRDAEATGDESSEGTDTPRMPLRRMPSGRFPIKVSSSDASDMRVPSGGARGPPPIPSRSHYRGLSQQNTATRRPGVLPLTIGNISERGRSNSETLMHSERSNSRQRRMGILAKKATSDLGTLDEVEGSNRWSHYRGLSHGSAMQGNQAAPSRSPATPTDSLQRPVYVRRLSVLPERRRESKIFDPVIEAAKGILYSVFQIHPMIQMLMTLTNDGSAKRSSLEIVFYNTNSHVEELEQEIQKHDMAMAEDEEGPFGDNANVHRACQTLVGAYGHVCTLLADNIDTFVNNGDARYIRTLLMLIYNSIMELRVTLSSVFSENNKQVNVPALEAPDNSNTIKPYFREAAAAVGAPQKPAPPRTRTGPVMHNPSNLRVATDIPVPYNNGGSRTAKIVSATPRSNDSFASSYAREGAGSDFSEDDAQFDKIYLALQRSTDIVLHILPNFHTQLTGGIRNAMQQRAPSAMIRDWKNLIAMCVDAIQQTEILKNRLSLIKLKDPGVRSHAGFWSLCSNFISAWTKMASKIKSEINTIPLPPDTRARLRPVHQSMKETSIIIMNSPWNYILRPGGGGGGSTSGGGGGGSNRGSGGGQGSFGPGALSPTTPQVPITPQSAALGPAMQATVATPQTGSFAAVFHGNVFERAETLMTNPGISMSRTGTMSTKGHSGFNSLSSVSSMSSDGVPTPSSAFSPSVPVGAAPFRVNGGKVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI60</accession>
    <name>A0A2T4CI60_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1435060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI60"/>
    <dbReference type="STRING" id="983965.A0A2T4CI60"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="32886" checksum="5D50624396F01C79" modified="2018-07-18" version="1">MSDDKADLLRFANEYADKNIDLYELLGVDALTPKEDVHRAWRKASLNYHPDKAREKFDAAKWELFERARDILSDPNARAAYDQSLKAKLLRKQEREAMDKEHQRFADDLEARENAHREQMQQQQQRDQEKLAKERERLAEAQRIHDEEKRRQAEAAEAAAEAAQKLEDIAEARRRLKERKEDKARRKQVKKSLKATGGIKKSTGPPNGAVLVPGDYVVDLGSERKKYWELVCDKLRAVQAVRNLQKLDVTDSQELEDAEKKMIEARQRIHDAEMKFQQDTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI79</accession>
    <name>A0A2T4CI79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_80654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI79"/>
    <dbReference type="STRING" id="983965.A0A2T4CI79"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="430" mass="47256" checksum="8BE28500F76ED7D5" modified="2018-07-18" version="1">MSLKIRKLCSADSFLLTFTPLLGIIRDPFHVLLNPVVEDPPLYRQCISSTRSIPEANLIIISPGRDTHLLEHSLLQILPTSTKTIILTDPATAKTIRGWRHFDDETVKTLSPWQDPRRKGQDTVLRLPVSPCYAGGGHGEVTVALIPQKRNDVCTRAAIGITYRPPPSTPSPFRRSIRTTYTTHMQIHPKTPPQLLISLPKPSLGDLTAKPTPPTPPDTPVPAHSPRSGTDTISLVPHFHRQTLSVIFSPRGTSYGSIEPYATSHLVSEAALPLTALMHSFDAESTPRWAIGRRHSCSRSLSPIGQETALALGARTWVRTQGSDSMNSRGRAVALSSKGSRTRTFLRHEVQEMLERAETAEKRGPSSCKTLMHSTRILDMSRGEEVTLTSDGVCDVSPVWQHQGSTPDALGLLSNVPWQGMVTLKELDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CID9</accession>
    <name>A0A2T4CID9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1012891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CID9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8521" checksum="F44EDD73B78FFD71" modified="2018-07-18" version="1">MPYGVCLDRALLIPLLTWMLRSCFISLPLLQGKILYVPCTFHCKCRVAPSPARDLDICLGEDISPQNSESSVVIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ63</accession>
    <name>A0A2T4CJ63_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1346583</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ63"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ63"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="396" mass="44702" checksum="7BAD238C720FF39C" modified="2018-07-18" version="1">MADKGLEDVPEGQIESNYDETVDSFDDMNLKSELLRGVYAYGFERPSAIQQRAIMPVIKGHDVIAQAQSGTGKTATFSISVLQKIDPAVKQCQALILAPTRELAQQIQKVVVAIGDFMNVECHACIGGTSVREDMKALQDGPQVVVGTPGRVHDMIQRRFLKTDAMKMFVLDEADEMLSRGFTDQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTRFMRDPVRILVKKDELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMDQAQRDLIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK42</accession>
    <name>A0A2T4CK42_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1427692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK42"/>
    <dbReference type="STRING" id="983965.A0A2T4CK42"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="709" mass="78877" checksum="C08B6532BF70D7E2" modified="2018-07-18" version="1">MEEPSPVPTVNPLPHRVRRMRKGTRSCTECRRRKTRCVFSPGDPVCVLCKSRDGRCIEQGYEDASLPGPRPSAQRKGPTNGKASQSRSGISADQPPKFCGDEETSDVLASERADHAPIVSLLVDAQLSATAKSGQDEASSSTTAYSSSTYTPLLDKCQKPSPWAIQPLGSKSAYVCSTIRSMLPSYDTIVSVLLRNGSWWDSFRSKAYAISEAPSQTIEAFAKRTYTSSNPADIGALAIAFARSLDKHRYLYTLVDDLVISDINYLTTIEGLECLILLAKSYTDCGQPKRAWLVWRKGASATQLMGLCCGRNYTRTEMRLWCAVYHGDRFCSMLLGLPYVLNDNHYQSVIQAPGMTPGFYFVLRCAIICGKIIDRNMTVGKPSFAKAMELDEEMETIASSQPQDWWSVPKSLDQLPEPLELNDLREKLLQQFYFYWVKLFLHLPFLVETTTSSPHYFSRTACIEAAKQILQRYRLLRSKMKSGHCLFECKTTDFACFTAAVVLLIGTFHSSAACRSSDTIEEDLELVADTDRLLMAEEVENDCRVAAQCRKVLQMLSIMEPDEADEDREVVIPYFGAVIRKRSHRTQPDPRHATLPRSVGHASNDLGEVDVPPPPPYNSAEQTAAIPAVDNPWSLNGFSLEYISHRGFERANLGGFLGVDDVACSQEDESTSYMASAAMDWDPGWSVLTDIGGDFMTGIEDLSAEDFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK70</accession>
    <name>A0A2T4CK70_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1397097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK70"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="768" mass="85506" checksum="5F535F22AA8C0806" modified="2018-07-18" version="1">MEPSKTSPSSSNPDRDPPPANAQPHRKPRTRARISAACVRCQKRKIRCDGVLPACSGCQKAGVRCVDGGTSREIPRNYLTDLEARVAWLESIVRDRCPDVDLASGPGRPLRAHASALDRGQSSSRQASQESPDETSPHEITEQMSLVSISGGSDLRYLGPSSGLFFTKFVLAGLAHVADIETVNLRGSTCKDDDALLPGDLVDLQAKDFPNDKRQTLFLTQIYFDSVHLQFPFLHEPSHHAIIDKLYNGETLDPLEEFHAFMVLAIGATIYGRRSRRHMLGEGYYASALQRLDIVFRTPSLVTCQCLLLLEMYTLHDPSSGLNIWTLHYHSLASCLELGLHRDVRSAHHFNPLQVELRTRIFWCTYSVNRQLCTIMGRPLGFFDEQCELRIPKDVNDDELTEEGVRPSARPPGSLTTMTSAIHLFKWARLCSEIKTVIFCTDRNYPPYVSPAITDMTAWRTDVISRLRKWRQEIPRHAEGERTHYLNDLCEIRYHELMMLILRPNPVFQKPTKASLCECFSSAIACSKLYAKLYAENQLRYGWLTVHSLFLCIMTIFYCVWTPDGIADQVNFDCLTASLKAASDILSATGEYWPEAKRSRDVLDRIFSATMRRFAPRQEFPKMQPLLSSPNSQSGSTGLSESTSISPQTASSTYGDGMLAPGDGVVSSETFDGLLPHGDGLLPPADPALASHGLSMADLTPAMSADFPPYPTTTLDSFMTTDWLSYFMNAEDFGSMNMDTNMGGFGGLDLTTDLSGWCQGDMSVLGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPC7</accession>
    <name>A0A2T4BPC7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide lyase family 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1366279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPC7"/>
    <dbReference type="OrthoDB" id="77013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015666193" evidence="1">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase 2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="248" mass="25869" checksum="D5D36CDDC44ACF76" modified="2018-07-18" version="1">MPALKTLIASSLLGAASALNPSCAPGGNFDLSKWSLQLPIGNPGSPTTIPSSQLQGCGGYQDPGHHYFFTESGDGALVMKVPGAPSNTGCVTTPNSQHCRTELRESNPSSWSPNSPNNKLTVSLAVEQPDNSGHGTVIGQIHIDDNTSTKPVCELYYNSSGVLAMGVEQTRAGGNEIITTVGNVPVGQPFTYTISYSNNVLSVSINGGAAQTLSTYSLDAPPSYFKVGNYNQGSSASDVHFYSINVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPL0</accession>
    <name>A0A2T4BPL0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1344489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPL0"/>
    <dbReference type="STRING" id="983965.A0A2T4BPL0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="537" mass="59592" checksum="F0D26EDD48FD67C2" modified="2018-07-18" version="1">MGAQSVIALAGITAVVSYLKLSGASHATVLLGLAAYLATQLALYLAFSSLIYRWFLSPTKGLPHPQHTSFILGNLIPFLSEPWGFPLVRWQLTVPPTASGFYRVFLGPFDYLIPRSSQAVNTIMTQPYLFHKPAAVRDGLVESLGVGLVSAEGPVHKRQKKLLTPIFGMSRNRRLVPQMWGKALILANKIQELVAKSGSKSQVLNMYPLTMAATLDVIGVTTLGVDFDSVTHPDQPILEAYQRVFPSFENQSAVDKFFGATLPAIISPHLLFKLPLKPIREFHRGMAYLQDFCQAQIRQKRQEIEEDEHGNAEIREKDILSAIIAAGLTDENEILSHTLTILAAGHESTAITLAWAIFKLAQHPDVQEKLRAEVLIATRNTGPDGLTLENINSMTYMRCFLMEVLRLYPAFPAMMREAAQEARVGDLQIPKGKQIMVSPYAVNRSQELWGDDAEEFKVERWEDSYSGGAKTSQAFLTFSSGPRICIGKDFATLSLKVFLTVLVSRFRFEEAIPGWHPMIQKGTSLKPQGLKVKVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ56</accession>
    <name>A0A2T4BQ56_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CDP-alcohol phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1406618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ56"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ56"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28815" checksum="67329DBE1DE3D0DA" modified="2018-07-18" version="1">MARPVVLCRRCLWATTSAGFGGRRPRRDIAPVPLALKITKRFNHQPGDQTDTSVAKKPSVNPAIHEDIYTIPNFLTFTRLVASPVIGYLVLQDAHTWAVGLLAYAGFTDLLDGWIARKWNRRTVVGTIIDPMADKVLMTVLTVCLAIKGALPVWVASIILGRDVGLAIAAIYYRWISLPPPKTFTRYWDFSLPSAEVRPTTISKYNTFLQLALVGLTTAAPILGVDLASTLTVMQYVVATTTVWSGASYVFSKDAIKILNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQC3</accession>
    <name>A0A2T4BQC3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1395638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQC3"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015505440" evidence="2">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="18427" checksum="F444F6AE12966EAC" modified="2018-07-18" version="1">MALRLLQLVSLLSVIGLAGSLVRGMVQEKVAVPSAIVGTLVVACIATAYSLTSSILFSQHLLPLLIATAADGTFLIAFIIASCILGKPVHNLSCKALPAHGNNNTGTFISFLFSTTTSNIVDPSKSACHSIKATWGLCIASTILFLASASIAISLWNTMWIRLRLCFEIGHSPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQW8</accession>
    <name>A0A2T4BQW8_TRILO</name>
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        <recommendedName>
            <fullName evidence="8">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1442429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-ulmin hydrophobin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101751">
        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015718361" description="Hydrophobin" evidence="5">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="24132" checksum="7AD9F340A52FEFD1" modified="2018-07-18" version="1">MKLLAVTALLVAGSLAVPAGSYPPPAPTYGDDPSGEVGYPSKYPSEYASQYPEYPPGHGGYGGGPDDGDKSSYAPPSTTQAPSYPTTTNGGEEETSYPVASSTYSSTSSSTPSPTTPAGDNDGDDGDDVPGTPEQPPTDGDSNPPDDGDDGDDTDGGGDDGDGEDGSSNLCAPLLYSNPQCCDASVLGVLDLNCTPPPSTPTDYDSFNDICQDIGKEAQCCVIPVLGQALLCEDVPLE</sequence>
</entry>
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    <accession>A0A2T4BR24</accession>
    <name>A0A2T4BR24_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1140895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="20285" checksum="D69574BE493410D7" modified="2018-07-18" version="1">MQLSAATPCDRIRSFGLESETTTDDPYLVLRRILIPFPPLVPSDLIPLLLHLPGPAGLANRCQATGTRARVPFSHLRFCRRLSRFSVCDSGQAGRANSRWGQMATLSASQSTETPANSFEPLPATPGLQRNPASILTSFAERRMYVARVAYLGFCIDLQVDGAGSSRQVSRESSSGCTSSKEAKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRM8</accession>
    <name>A0A2T4BRM8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin class II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1395243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
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    <dbReference type="OrthoDB" id="1293114at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="226"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="2231"/>
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        </location>
    </feature>
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        <location>
            <begin position="2274"/>
            <end position="2292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB71971.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2292" mass="252980" checksum="70DF83E4FC7A30C8" modified="2018-07-18" version="1">MCHVQRGGKKTFATTSSSTPSSTIPLPPAAPAQDGLGDESQGSRTPTSPALSTASTADDEDDDIGSSPALPLLPAPKLPERASAILRASAFDIHDFRVDDDDDDEPDDNLSSDDEQFGTASWGSPYLRSDLNLRRQSYASDDESESEGSESFPIHSLDISTPFLRPPPLIVGGRPQTPAQPLLPTSAAAAVLVHRARQRNRGLTEGWIRTHTAGDQNTEARLWFSDGESSEHSSLSGSETDWHRRRDPRTPTPSGRYRAKSRSTSRHPRAVSSVETLKAGDHAQAELEDEMDGSVATETGSVVGPPVAERRNDMTNGEAPQPAAGNTEVPALKLADKPLPREPAATPRIKKKVPWKGKNIMILIPRDDERGRPGQPPLPLRQDEIERMFDSWTELGYSVDGFDLSAEDNVVGESQSRELWPSLDDLAQERQEREYTVVLPDLNAWKNYVNELQEAKLRALGVSFGGDEPEVAPSISSQPSRMPSAQYPPLPFSPPIPTSSASSNHAIPGFPFPAPFIPGAASTQSPGLPAGASPVPFGVHGKFSTRQSISFPATSSPFQQPPQGWQHQAGAMQGLSPLDSPSVMSLNGIMSPQSPYGIEGFNQAGSPAFNLHQRHQSLQYMPQQYARASPRLQDVREDEEEEEQQQQQQQQQQHTGKSPSRTPEPAQRNADQLQAEIDDAEYHLEEQLRNELEHEDYNPQTRAESINHQPFVSGHGHQPSAGGFATVEHFANEPNKPLVLHHPRPHSRGHSLTQNFYRDKDAPDGVSQGSVPQFAPLNDIPETQRVDEAYDEIQTNPSNLGTPIQDIDFAAAFSQHQKNMSASSNPWQDAVSLANGGSQHSAQDSKSSLSKFNVEAPEFKFNPTSTFTPGLFNFANSGFQPAAFHAAPPEIADQTPFGAPPQQPPAAKINVNAPTFAPGQSEFSFSSSGPKFRPDAPAFTPFQSQAKSAPSAAESGNKGFPRRTDSIFGNINIEPTAMPSPKKSKALPITRPSSTVSADSPAAYEGDVRDPEGRVGDISRVKRAKSANLSDTDDVPRFADRPANESAENLAEEEAPAMVESSVKEARSVAEEGSVDGEVVLPADTSMSSVDQIDTQVTSAAPSETSPAEAFAKWRSSFQHTPRQHSTATPVSLPEEAEPRSDGEELSESTQPQVLSAPEDPQTLAARRKLTPKGLAGSRFALPPPKPSGLAASRFAEPTPAPTAEQDDGAVEQEQEETSGYNPTSTTAGEKRSPTFEEIDAVMQRMERYHSQGINKSVETFQWPRPSVEAPASSDELHIPSDHAREGMSIVPRQYSPVPDNASQPMVTTELEDPFVDPPMSAQAPRRGHAFAEEELDSEPLSDWEGAFSEDEHSKLQHRAQFFDGRVSEVVGNLLASRLAPLEKVLLSLHQSMAYKGQRAPSSRRDARGGSMEYQESDADDEDDEPVPRRSTSPKRDRRLDQIRSIVVEALASQQRSPLALTAETSEDTTLLKSLGEIKELLISSARPTPRGDQSAPFDNMLQPKPDEELLTKIRDLETKNADLESRLRLDQENLEREVSERRAAEDAAAELDRKLQAAETRVEIEILNRTVFDQRVAELEERLRNQEDLAEQEVKARRTAEDSLSEVQRLFRNASEEEARLREMVEERDQVIKTLEHSTSKTTMQLTALETARDNWTQQQAEMVNTINVLEADLRNVRQDNNTWRAEAERADEAARRSNGELGHALDENKRLHRSLTSVVAQLEENERLRESWRVKFLSLQDDMGQAAREVAEENARRIKRDQAMLARQEVLEARLQAESKTRERLEVEMERLQDNERAGMRAVNECHRLEEMLSELRAENFKLQQSAARYQREFEEARESGASEVKRTRMSLQTELDAANNQVNVIREEYEEQNAKLRAELDHLKLAIDTAKAQNEMLLEGAQASSASELEELKRKHQNELEDIQTRYERQVHNAIEDGQRTEQHLLERLSLSTSKTEHLQDRILHLEEKLEITKQAAAAAAQAAKSAGVDSSVLNSAMAKPAQRVEMPERISPQALRESIMVLQEQLQAREQRIEELEQTVAELDPDAATKISKRDDEINWLRELLAVRQGDLQDIISALSGERFDRAAVRDAAIRLKANLQMEEQERERAMNGGSAITLPNIAQTIQAATPRVAQTIAPIAAAWGNWRKSGQSGFRGISGVLSSPAVAGNSTPPRSRDDPMQHGGVASGLLTPPATALRQSPIQDNHPQPTAFSSIGRRFTGQSVQERARRESNVSHRSDKASFHGLPHRRQELAAEPVRPSSMIHQTAYDEDAQPGEFDDHDFFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRX1</accession>
    <name>A0A2T4BRX1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1395072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRX1"/>
    <dbReference type="OrthoDB" id="10536301at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="231" mass="25625" checksum="3EE51A9AB64B3C3D" modified="2018-07-18" version="1">MREHFERLVVKKRYKRTERMSESYRMNEVFRERFGERSVRHVRFPPHHLQSPDTGTIRYITPGQPGMPPPGPPGPPGPPPPPQQQQQPPPPGPGPQQPQFGPFVMAVAAGFAAAPPACLGMAMGMMNGVMPGMPGPPGPMAPPPRPEFPLTVRDNTRHGSHTYTIAVGPTDTTEFIINFLSPSSRCGLETLTVQWKDTTREPLSRRIPVEELRAQAEYIIIDVLEPRFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS35</accession>
    <name>A0A2T4BS35_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1342722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS35"/>
    <dbReference type="STRING" id="983965.A0A2T4BS35"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="58"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="504" mass="55631" checksum="112A899569C260B5" modified="2018-07-18" version="1">MADSGKTILHINFADIIDQPLSLNGATRHRFRFIDVDALAHKSTIHVLEFEDLPSAPYAVISYVWRGLPPLPNETSTLPRINVKGAEGADPISVEGLRIVSLAAERQGCKLIWLDALCILQDDDDDKAWQIQRMYDIYRSSSECIVAPGGLQRLVSLTEETSWASRAWTLQEAIAPPSVHCLFAWDRGDCCFQSNFPLRVTQLEGTRAGIASLKTALEMAMKGSGVRLFDLQGKEMDLPSEDYRILMFGDAARDRPRIRELIDAMDMKGKEGMFTAIWRSSFMRAAKYPVDAVFSTMGIMGVTLDARKFGNEDRLGATIALMRAILARGGRAEWLGIATKALPNPRLSTLPVFPGVDAARRPILEMRDGMKDVADVMDTGWRLEGTPGGVMDADGYFRFSALATSVRRTEENGESARVFRSEGLGNWEVVGRGEGSHTAVLIGRWEQYNNGAFGVMRNPWDQALMILEEGSGGRFSNVGYAFVKEEVVKTGSWGERVVVVGGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS52</accession>
    <name>A0A2T4BS52_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1442125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS52"/>
    <dbReference type="STRING" id="983965.A0A2T4BS52"/>
    <dbReference type="OrthoDB" id="5292518at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015617939" evidence="3">
        <location>
            <begin position="25"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="393" mass="41914" checksum="362912A686BDA869" modified="2018-07-18" version="1">MLVPASALYGLVLLAAFHGSIVDALVIRGHHGFQLVAKSPRNTEPSTLLQRKDDACGADMPRCSASSIGNCCPESYDGQAAVDTTPTSVPKYVPSSIETDGDDGEDESLSTTQLGGIIGGAIALLALVIAAACVMIRHIDKLAAQISRKSNSSRSRTTTKQTSLSSLSSRSSRTDSTEASTRRSQTRRKTRSTARRHRQRRNGFIAASSGDFLIQGAHGRLESAQDIPLQVLTRTTDSCSAVVLDSRRMDVVSPTAINDVSPRQLSSPSPLSVASSELGASSLAQELAGTSNAVTLAADSLIHDAQDIPPTDLPRVATRPPLAYQWMRSIGLLRESETTDPEDYRIEEESHGFYGSRDHVAGRTGLGIGYTEMRGGGPGHYFCPMPKRTYGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSC1</accession>
    <name>A0A2T4BSC1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1425705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSC1"/>
    <dbReference type="STRING" id="983965.A0A2T4BSC1"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="103" mass="11374" checksum="1B5578FA88B62F9F" modified="2018-07-18" version="1">MPRSRSQLIVTADAFCTAYSRWTVPDVLSIRSPTCTHCVLPGDQPPRNNRDSGEILNGVIPVKRNIHLQPVDTMLLIVDGESRKLMKHLTSTAETDVGPHGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSH9</accession>
    <name>A0A2T4BSH9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1441972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSH9"/>
    <dbReference type="STRING" id="983965.A0A2T4BSH9"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF78">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="451" mass="51550" checksum="243AADD819C4C5F3" modified="2018-07-18" version="1">METIDTSPVPHLSSSWQLVAGGAFLVGIASHHPVFRPYEIDTYVWQLIFAYIAVTAALLARCVLTGGYQVTTALIYTLSIASVYNCSVLGSILVYRAFFHPLRHFPEPFAARLSRFYAMGKMIRSRKGYEDVQRLHEKYGDIVRVVTRPPWYAQMSRHAAKSSLVNTRDVVMHRLRKKLWERALGPRALEVYEPRVQAKVDLLMSKVAAAKNRPIDATRYFIYFSFDVMADVGLSKDFRMLESTSYHPAIEGVHRTMSFIGILSTVPWLIYMIGSIPGLTTFNRFSMWCRDEVDEKREAFAMNKEKEPQDVMSWLLGAMNENDPSAPPSDNPYIDHIIHETMRLRPTVPGGMPRTVPPQGLFIDGQFIPGGTIAAVPTYTIQHDERYWEDPLAFKPERWEGWPWTCPGRNLAMMELRMALSRIALQFDVGDTVDNVSMRLPELKLVFKPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT16</accession>
    <name>A0A2T4BT16_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1472797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT16"/>
    <dbReference type="STRING" id="983965.A0A2T4BT16"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="97"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="252" mass="28842" checksum="426DC2DF407B219F" modified="2018-07-18" version="1">MGIPTDIVLYTAATPNGIKVSILLEELGLEYKIRSIDLGKNEQKEQWFLDINPNGRIPAITDTWTDGTPIRVFESGAILQYLVDRYDKDHKVSYPRDSKETWEVNSWLHWQMGGLGPMQGQANHFNRYAPEKIQYGIDRYTNETRRLYSVLDTQLSKSSSGYLVGDRVTIADIASWGWVASHAWAGVSLAEFPHLEKWLHALLERPGFEQGRHVPKPHTAFELAKLSPEEMDKKAEETRKWVQESMKADAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTI0</accession>
    <name>A0A2T4BTI0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ER glutathione S transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1405546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTI0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTI0"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16112" checksum="D949728CB6DF2794" modified="2018-07-18" version="1">MAIALAVPDSYGLVLAAATSTFFVNTFHMFRTAKLRKASNIPYPNAYATHEQAEKDVNAYRFNCAQRAHANFIENQPTALGALLISGLHFPVAAAVLGATWSVGRTLYLYGYTSSAGPKGRTFGAYLAGVADLGLKFMAAYTSYLFVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTV8</accession>
    <name>A0A2T4BTV8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1312541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTV8"/>
    <dbReference type="STRING" id="983965.A0A2T4BTV8"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="67"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="178" mass="19930" checksum="FA19DF68C6A568B4" modified="2018-07-18" version="1" fragment="single">MARRQHLTATVLLAVVLFFTITYLLSGTSSPGVDRTPAESKSEFKVDLDDMPASLLEGDSIAPKLENATLKAELGRATWKFMHTMVARFPEKPSPEERKTLETFIHLFGRLYPCGDCARHFRGLLAKYPPQTSSRNAAAGWLCFVHNQVNERLKKPIFDCNDIGDFYDCGCGDEKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUA9</accession>
    <name>A0A2T4BUA9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1433645</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUA9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUA9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB72894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="518" mass="59062" checksum="3EF489E12D556BD7" modified="2018-07-18" version="1">MISTMSQSIQEQILGLAWSLAVITTCLIVGLGVLERVIVNHRLSKTNGVRASILGGNPITSFYAFFKAGYMHAHNRLQENFTDMFTHASPSCPHAVEITIFGHRSIMTIDPEHVKALLTTNFAHFGKGPRFHRTWEPFLGDSIFTTDGRQWQQSRTLIRPMFVTQRVRDLDILERWTDVLLAKLPASGQTVDVCDLFYRMTLDAITDYLLGQSVESLDNPNGEFTNAFTQVQRTQMLLAIFAPFQRFVPQAEYRKGIKVLEAFIQPFIEATLALTPEQLETISKSDREFTFLHHMALFSRDPKVIRDQLMAVLLAGRDTTAATLSWTIYELSNYPEIWRKLRCRVLERVGPHAAPTYEDIKDLTCLTHALNETLRLYPAVPYNVRSCLQNSTLPGKPGQPDIAVLKGDHVLYSTLVMQRRKDLYPPVSDKFADTAVYSPERWEHWTPKPWQFIPFNGGPRICIGQNFAMTEMAFTLVRLLQRYERIEYRGDWAAQYLKADIVGCPGLGVPIALYEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUV0</accession>
    <name>A0A2T4BUV0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_141912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUV0"/>
    <dbReference type="STRING" id="983965.A0A2T4BUV0"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="230"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="437"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="679" mass="73516" checksum="5DFB707D6E76EAEF" modified="2018-07-18" version="1">MSAINGLSNIQIGDGGNLGARNASLRHPHDHANEVSGAPQAIHVPPKLQSSYSANDIPTVKNPGGTSMMSPIANNHAQQHFHNHNASIGRIPAGVMPMRHTRELSNDNGVNASREQAAVYPSINSALQASAAPFGPTMTTAAPLATPHTAASMTSPGSSASASSSHVAGFYRYTPSSATSSSSYGGNSLSAGMQQLNINGAGGGNGYSPQGYSPYGNVPYSPPGGQHRDSQARVIQHRRQLDSEAMSRYQNMPLKSFEGQIYELCKDQHGCRYLQKKLEERDEKQVHMIWLETNQHVIELMTDPFGNYLCQKLLEFCNDDERTVLIQNASQDMVRIALNQHGTRALQKMIEQVSTPQQVHLIIEALRYRVVQLIQDLNGNHVIQKCLNKLTASDAQFIFDAVGEKCVEVGTHRHGCCVLQRCIDHATGDQKLWLIQCITKDARILVQDPFGNYVVQYIIDLHEPTFTEPIVASFEGCISMLSRHKFSSNVIEKCLRCAQPPSKDMIVSEILGDIEGCLQDSFANYVVQTALDFSTPQLKHRLVEAIRPVLPKIRTTPYGRRIQAKISAYDNRGSAASSGQATPADNTQGQIPLRPSHSRGLSGTPVLPPALPTSVGTANGVAHGAGGQGLRQQAPPPFSGNTTMSMPPSSGASGPGGLIQAAQYNNPMDDGETRWRPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUY3</accession>
    <name>A0A2T4BUY3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M440DRAFT_1404783</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUY3"/>
    <dbReference type="STRING" id="983965.A0A2T4BUY3"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000233">
        <property type="entry name" value="Probable glucan endo-1,3-beta-glucosidase eglC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015445132" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="24">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PTB73056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="479" mass="48704" checksum="0E1429FCA559DC40" modified="2018-07-18" version="1">MPSSSTLLALATALSAVNAAYTGFNYGSTFTNGQPKAQTDFEAEFRTAAGLDGTDGAFTSARLYTMIQAGTANSPISAIPAALSTKTSLLLGLWASGGDAAFANEMAALKSTISQYCDQKLGDLVAGISVGSEDLYRITPTGIASHAGDGAQPGTLVNYIGQVRDAIKGSCLADVPVGHVDTWNAWVLDSNKPVIDAVDWLGMDTYPYYENTNENSIANAKSLYEAALTKIQNAGPGKPVWVTETGWPVNGPKSGAAVASTANAREYWLQVGCPNFGKVNVWWYTLQDAAPDAPNPSFGVIGSQLTEKPLYDLSCKDVDTKPQQPATTTATSGAVTETTTSAVASSTEEASTTTEVVASTGTVSEVQTTTVESQTTAVATVTTGSEQTTVSEVQTTVQTTSFPAITAPTSVIVVVPTTLSSAPFPSSNSTAVGGGSPSASAPGSVPSSPSASNIPGSSGSKLSSFGAAAAAIAVAAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV28</accession>
    <name>A0A2T4BV28_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1340352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV28"/>
    <dbReference type="STRING" id="983965.A0A2T4BV28"/>
    <dbReference type="OrthoDB" id="4939498at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="359" mass="40070" checksum="427B195D56846527" modified="2018-07-18" version="1">MSLHQRVSANSARRASVSQAQSPYATPDFDRRLLDSLNNAHTELNKTNSERDRYLSLYTQADKKLAEATATITDLKAQNQTLKDSAVSFQERYELLKKENDRLRHEHGELARGFDDLKAKYTDLSHRYTTLNSASPAYSSNAGSNLSGSVPERPKVSRSSSKKERKEDREERSRVRDREKSRDRTKEEKRERDKDKEKDKEREKEKKEHKAEKERLSRRFEERRPAPPAPAPPPPPMTHRRNSFIEGWGPGGRSSSASGSSTRSYTNGPNGINGPNGLHGPHGGPHGHNGLGGHRGHVQVPAVTPGGKPVYASIPRTATDPMTPRIFSVAGSTAAVFDDDGSYEDGNYHPYPIPQSRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVV6</accession>
    <name>A0A2T4BVV6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_21680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVV6"/>
    <dbReference type="STRING" id="983965.A0A2T4BVV6"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="181"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="613" mass="67364" checksum="CDC761FDEB63CE1B" modified="2018-07-18" version="1">MLRCGGSAAQPLRAQALRRLAAVPRPGGAAAAAARHYATDIEPERPKPPRQGNEQKLGRSFQGQVMGSIGARLRREREQREQYEKWRDMNDPARNWMITFFFLSSVGIAYWLGTYWPRDPEPTSTLPLSKVRPLTHNVKLENMQAAWADFVKIVGKDNVSTDEDQVSAHATSDWSTHVAKPDERPFCVVYPGSTEEVAEIMKVCHQRRIPVTAYSGGTSLEGHFTPTKKGISIDFGRMDKILALHQDDLDVVVQPAVGWEELNNVLAEKGLFFPPDPGPGAMIGGMVGTGCSGTNAYRYGTMREWVLSLTVVMADGTVVKTRQRPRKSSAGYDLTKLFIGSEGTLGLVTEATLKLTVKPESTSVAICSFPSILHAATCVSKVVGKGIPVAAVEILDDVQMKCINASQATSRTWAEAPTLFFKFTGTPLGVKEQIAQVQALASQAGSRTFEFARSEAEREELWSARKEALWSTMAMKKEGDHVWTGDVAVPMSRLPQLIEETKADIQKSGLFASIVGHVGDGNFHTILLYNDAQRKKAETVVSRMVKRAVELEGTVTGEHGVGLGKRDYLPHELGETTVDAMRQIKKAFDPLCLLNCDKVVRAQKPKSGEVKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVZ0</accession>
    <name>A0A2T4BVZ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1339393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVZ0"/>
    <dbReference type="OrthoDB" id="5541877at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039966">
        <property type="entry name" value="C553.12c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="622" mass="71212" checksum="606CEC96F529F514" modified="2018-07-18" version="1">MPTFFQFTQGSESRVRPTDSSPLLGRYRAVPPRPRRPSSPLGLLSARYENGRDSIHVGYGALIVAEIEAGLLDGRDGSSAGDTTEDGEPRSKWERLWQSYFIDLFVNPRPSAVKRVVDRWWTRYGLLVLLPAALAVAWCAVPFPQYSIPDNGDDGDYATSLWLRLTRSVATLDPKIPGHGEARVQVNFWFFLFVYYGFYNLSALIWITKVFNLYNLNWWPQSFGFPVTVSLLAVISLAVPIPVYFTPSTRFLTAHNTAWVSWTFIVMAMPVAISFLILMTNERHIKLRQSLSETQRIFTTSWWTGEPDSFPHRQRRRHDLTDDLWEQDALRVLPPAGTSRVALRRRWLPASFVRFLWFCVALFIGLMAYVLGEAYAEIYLRTLPHNNFETVVYVYGWVVTVHLLDALTGWVLGIKEGERVGSYPLSWVFKLYFMLTYQTYVRALYARLRSPSQFVILQILSSTGLVIITPIMMTRLFHRILTILGLSGLTYGTYQKLQTRNLFIRFLAENTSMATFLGSILVLHFGANKDVYPYFAFDKAEDETLQYDFNLTFYASMVTWGCELVASLVVRGLIALFFGIDVGLEGKLDLAVWPELLPTSVAVMLHVLQNMLFSIIRLQFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW58</accession>
    <name>A0A2T4BW58_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1394076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW58"/>
    <dbReference type="STRING" id="983965.A0A2T4BW58"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="292" mass="32854" checksum="9638DFC3F484E9C6" modified="2018-07-18" version="1">MAFWVVGGGNPLGDAASSSRGQVAAYLKGEALGSNGKRRALINPKSREADFPLDNDALRSIFSAANELFFANKLTQRVTWDWSHPASAQYESHIVGTTALRRSVRLGGYETLIVLSSPILKDTKYNRRLLISTFLHEMIHSFLFITCGIKARYQGGHTEGFRQIAEIIDDWVGAEHLRLRDMEADLERFIDDGPPTTAVRASIEGGFAHSNHYYYGGGGNGNDNGSIHGHSHSHSHNPPKTWPVSEWQHAENRDYRIIEAPQPYTRYPSNYDEWEWHDSEGFPAHTAHPYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWH8</accession>
    <name>A0A2T4BWH8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldo-keto reductase ausK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1339881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWH8"/>
    <dbReference type="STRING" id="983965.A0A2T4BWH8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000024">
        <property type="entry name" value="Aryl-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="388" mass="43280" checksum="24651D609A949323" modified="2018-07-18" version="1">MGSKATTPGFMQLSPEATTELQRYRVLGPNAGIRVSPLALGAMSIGESWSEFMGSMDKESAFKLLDAFWEAGGNFIDTSNNYQDEQSEAWIGEWAAKRGIRDQLVLATKYTSDYRSHELGKGRAPNFQGNHKKSMFLSVRDSLKKLQTDYIDILYVHWWDHTTSIKEMMDSLHILVEQGKVLYLGASDMPAWVVSAANTYAIDHGKSPFVIYQGRWNVMVRDFERDIIPMCRQFGMALAPWDVLGGGKFQTKKAIEERKKNGETLRGFTPARDQTPDEEKVSEALAKVAAEHGTESVTAIALAYVLHKAGNVFPIVGGRKVEHLKDNIAALSIRLTDEQIKYLESVKPFDLGFPLNFLGQDPNVTGYSVRLDRTAKFAFPNAGTPKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXA4</accession>
    <name>A0A2T4BXA4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1769-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1471902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXA4"/>
    <dbReference type="STRING" id="983965.A0A2T4BXA4"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="334" mass="36295" checksum="40D8B9B0C00E5A5F" modified="2018-07-18" version="1">MRITRTPKDTCNDLADIELSVRIQDYKGLPRGSPSTSPYFSTEPHASNQDQYSIAFRFTPLKPAGGAAEDGDDADGAAAASGIRAADLQFGNDFDRPIRDKLPPGFNYAMNIVKWWIDPGLEGDAYADKPYLYGPALSSFNVVSVGPGEFDESKGGLWFEEGGDERGKKVREMNGVPKESKPRMKWALSDANKEKWTWEYGQTYGIDFFNPYLDFANMAIRLPGFQLSVAKYLGAEALKNDGRLAHQLRYVLRNKATGDTYLVITFALYLAESIHEDGTVKTANGANGTTNGHANGHTNGHTNGTTNGRSEGTHESNSTANGSGGGGTNEEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXX2</accession>
    <name>A0A2T4BXX2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1040782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXX2"/>
    <dbReference type="STRING" id="983965.A0A2T4BXX2"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="255" mass="29491" checksum="73AD45314E461928" modified="2018-07-18" version="1">MAAPRQEPLLEDIYGFLQGHQEKKFRSTATGSSEYTHLELFPKAPRDALTLSEDSRSHPSETHVSSVASGETRRSSIFDTPGYSSSTSSVLPGRQQRLPCEFFWYGDCEETFGLHDINGWVHHVATQHLDMILPTKCKCWFCDEWVFLAEPEDFQQRDLCYTARIHHIAEHYRQGAMTTDVRPDFDFLDHLWENDLISRRDFQYMKDYHEAPQPRNGINPIPTAPSARSTVAVAVAVEVRPRHRGRRESRRSYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYA2</accession>
    <name>A0A2T4BYA2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1338032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BYA2"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1564"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2081"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2410"/>
            <end position="2430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2511"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2420"/>
            <end position="2430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2545" mass="285308" checksum="A8FCA14FBC8CA86B" modified="2018-07-18" version="1">MSDFAAPKASPEPSSTRLNPFDDSDISSRKRRRTSVSASGSPSASPSPDSNEPRTPPQTVDSPTIPPDPPLSNRVTINLRNQSSRASTASPTRPAREPFVISPSADKAKKSVEEADPPSDADLESPPPAWRASLSPPTDDLFPGDQDMPDETAIEPKSDRPSPEPADDATPLVDPTTRFPYHEPDKPLADTANRLRQCLLDDLTLDAEADLYEQLRSWVDLFVAFAKTASPAEVLESVHSNAAFWQTFLGISAIIGDENSPSSARPRVSTLQRLAHLFSHSFAALTAQLVIVDFRSVNEWQSSGPLQNSPSPLLISPGYLRQLHQLIQFGQVSDSISANPTGVDRPNLATCFADGVYAFTGGGFESLCTISTSLAEVVRAFPNFVNILTPITQVLVDCLYESLRAIPAGTQGTSDFAPHLSAAYRTWTFLSSLLVEIIDKHVGTLSSEGVSLQIAALSDMLRLCLQYDQNETILLLREHRAKYPDLVGPRTVDAITWEWKADVLGRLIRSSQLQLRVMAATTMCNELVSAWKRFGVPSAHPNPHFTDHLGHHLLRTGLVDYVLGPNCHPELINESANIIGYLVVTKLYDKDHTDRLWQRLTESQDPRIEKAVAKMATSITNLFDYPTLLLLCEKFQALPMKDFNQTLKNYWAVVHHELMMRCKTEGITLGFLPYDLCLRLLREAFLQSTTFQMYIPDGQIKAATEKLKNLLFYGPDSDGRQDLYASCIQDIAAKSPTSLGSLCCLAITIRPNMADEMNFLIEKHDLVRLLVEELEHAIQSTRTAGIRPVLHGQVNHPRKDFIANLIRLRPDAIPEDLGRKLWDLLVGPASLCEEDRTSAWDIFMEFGHGLAFENPFLRLCFSRYLPELPSSCFCKGLLNCLKKVIASAIAEDGIRSLAVGLYLESQAITTYSFDRARRVHSAFVDRCLNQLSASASKIKASSDGTSSGEDEPMVIVATDDEIQEQERIFTRTLQLLRVFVQGHLANPALSAPDFRPYFQEQLYQVEGELAPLKYQSFDEGPRAEVKPLCIGRLNTAASLISNLRHETGFSNFRIIYKGRQFAPSMDQMTQSLESLHVEDGIMLVIREEDDTPESSARIQHGASSLEIRILSRFPELWSYLGMEDKIASEVYHLLIDLPVDGHIIDLLESQSTVYTDLFPPGQPYKTLYAIGALHKYLEPIRSKGSPNNVAGGDVHGFSQASNEDVLRSSLSLIVQAISDETFLHQVSPGLSIQLMEALMQTFVTLLTIIQPSAETSATYPSADRLIHILADARMAGGNEAALSLLENTLSVILRLCLSQGAFMESVANHSSFGNVLHDLILRDSRPQVRRRVVDMIRTAAESEGRPFNGPESVSPEEEGYDGALAYPLTRYFWSTYSALLPEAIGNQSRCQEVFEGLEYFFCRMSLISPSAVDVTAFARQVCELLLNHTSTERLDQPESQDFAAAGLSSLLLRCLQLDNNLPASPSLPDDLAEILFQSHLFPQRRIETTQPVPRVVLRTDTRARLYEAIFALTKDYPDRFWAILQNLNSLVPYFPDEDDGLDPYIYDLPYNFNRNQAIRSHGYVGLQNLSNTCYLNSLLTQLFMNTRFRQFVLESNIREPGHSQQLLFHMQKLFGFMQESYRRSVDPTDLVSSIKTYEDAMIDIHNQMDVEEFYSLLFDRLESQMMTEGERKQLRSIYGGQLVQQIKSKECEHVSERLEPFSAIQCDINGKKTLHESLQAYVDGEVLEGDNKYKCSSCDQHVDAVKRTCLKDLPDNLIFHLKRFDFNIRTQQRCKVNDHFVFPPNIDMRPYTIDYLSDPMKDTNPPDMFELVGVLVHSGTAESGHYYSYIRERTSTADCPRWVEFNDDTVTPWDPRQMAASTFGGPIQQSSPQFSDRQLTDKTYSAYMLFYQRSSSLLAEQQSLLPSPEDTIPFQIDTDPMLREHILNDNTVILKRHCLYDASHAEFVQHCFKHAGFLQNSISRDGAGQQQEQPPQGSDEDTAAMSSHAFKDLAMEMALGHLDQLVSRQQGTPHFEQFSSLLRAAVVECGDCALAFFNYFNTRHEAFRGLVQRNPEAKIRAFAGATMAIVLGKIATETPQLYDRPRSSDDASQDDGEGEFASNPLGHDELSPKAYVLTGVMCSFDYLWQHFQFHLRSWDEVFGMMLDFARMGPREAAHMLANDYLLKLLRIIAADVSMELPPNYAKMLHSIYRRAVNRPPSYVSILNLINYLISQLDPTVDAQSIVDAAEDRLRFFQPPFPWTSEEVFLIHSHPERQLASIFVEKLLGIDQALEATHGILGRLTALSNQMDQRVLNTLRNRIRGDMTEPMDPFLRGACIYLEHTPSASHMRALTNHIAAQAGGLQSTDEAKAFLEHFQTALNLKRSDGEMAQTAEACSLESLPGWVPHLLVFPDGEVRFDTECFLDRELFGPAGDGSDEGPQKQREREGSRTIIQRLGISCLQYLQNEHIRRRKLIGRESASAVIRVVARCNPHFSSEPDPDDENSIEFRALQDEVLGSLRKYVVDEVEDDGSDWEGSCISSDALDGQPDIGVQQIGELDDANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZM0</accession>
    <name>A0A2T4BZM0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1403218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZM0"/>
    <dbReference type="STRING" id="983965.A0A2T4BZM0"/>
    <dbReference type="OrthoDB" id="5291209at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42776" checksum="ADDFF62DAA2E1A7F" modified="2018-07-18" version="1">MQRIFAFNTLVQDTCSSSITASSGAPDLSQYTLTATLPVVHVDPPYTWPDYAPSLSIYLHPPASPSFANVSSKALLTPVLDTGSNGLLLDALDLNITNATLGQYEPGYQYLSSSTKLYRGSWIPFTLEFASPSGEPINVTAEVPILVVNETLKCSGYQDGWEAYCPEDHTSSFDPHPRGTTWWGIGFGRESDGQLHATPDKNALINIKSINGVDVSSSKHYRAGYSLRKNGVVVGLTEENTRGYRWTKLEEQRDFSDDPRDWKNVSGCVSIDGGDCRPSNILVDTGLTRSYLSTADTSVRLVPSNTSSTAKVLAAGQKVLVRFGSGDGDGEVQYNFTVGDASSLEAPDEVRTKLVDEGKEEKINTGVYFYREWESAFDAEGGWWGIKYVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZN6</accession>
    <name>A0A2T4BZN6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZN6"/>
    <dbReference type="STRING" id="983965.A0A2T4BZN6"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="541" mass="60189" checksum="A44EB42E13BBA24B" modified="2018-07-18" version="1">MDAYAMYPASLSKQASSRIYQDLWASRLHSLVQLASDRSVKTVAAMESFKQRRKNVPDSKPHVGIIGAGLAGLRCADILLQHGFQVTIIEGRDRIGGRLYQERLGNGHLVDMGPNWIHGTDDNPMLDLAKQTGTAVGTWDLTSYVFDEAGSLLPVKEGEALATMVWDIIQDAFVYSNKSSADIDENISLLDFFKEKVVEKIPETEENFQKKRETVLQMSEMWGTFIGSPVGQQSLKFFWLEECIEGENLFCAGTYQKILQEVARPALSNATISFDSVADKIFSRRKPDDEVRVQLKGGQTLSFDELVVTCPLGWLKRNLTAFDPPLPPVLTKAIGSVGYGSLEKVYISFPKAFWLPAEGDGRRVQGFAQWIAPKYHAENHRGWNQEVVELASIAPEAAHPTLLFYIYGEQSDFLTAKVAELESREKKDAFLLDFFKPYYSRLPQYSEDSADCQPVCCLATSWVRDELAGHGSYCNFQVGLTHGDEDIKTMRHGLPVQGLWLAGEHTAPFVALGTATGAYWSGELVGKRIAEAYNCSLQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZS5</accession>
    <name>A0A2T4BZS5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1440232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZS5"/>
    <dbReference type="STRING" id="983965.A0A2T4BZS5"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="40206" checksum="920FAD9F331249CF" modified="2018-07-18" version="1">MGEAFQCYPIVVGIVSHIDLNTLDALARSCRLIHDGLIQYRTSLMAATLRCSREAVPVDPEQTLRYRARASDWNYMDDGRNYSGKAGSCARDLVTECRRCADVICRNCAIKPPLSTALRERHRRLCVTCAKAPIAALASPALDPSLPLDSDAVQRAICQCDTEGVWLCQPCGHSIRNADHDYKGIWRWRTKYGGFTGIGDGDRGVICGRAEACLAAREREQETDCDAEDARGNTLVPWSTGSSSGTPTPGSGSGSGPPHSGTPPGGGAGFPFPTNGTIESIIDEMRHQRTPSPQLGPGYERHEIEGIGGIVKRKLVRMVRVGACVPEWEDEKGSGNKILAREVNGAARSWCGWCWRVIPGDKDKKQVAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0F6</accession>
    <name>A0A2T4C0F6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0F6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="8723" checksum="D22EDD0114B3A561" modified="2018-07-18" version="1">MDGREELGDISATPPVAAAFSSSLMTIDQTRRSPSRKSDEAERRSSLSVSRFGPGERRRAATLEAGEASRTGKRGGGGGGNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0R9</accession>
    <name>A0A2T4C0R9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucooligosaccharide oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1379155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0R9"/>
    <dbReference type="STRING" id="983965.A0A2T4C0R9"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015542368" evidence="6">
        <location>
            <begin position="22"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="502" mass="55321" checksum="BC0582A2D7B57707" modified="2018-07-18" version="1">MARSWILSVIAFIGVLGNAAALPKDYGDLPTVDLKPLLIDPIRKWSSNTTVSFPNSPAFEASTERWTIADPPTYNAAIRPGTEEDISKVINLAKSKKFPFLTRGAGHGYSASLGKFQHGLSLDLSQWKYLKIDKKAQTLTVGPGVTFADIFDPLFNAGFYIQTGSCSCPSMIGVTIGGGIGRLMGKYGLLVDALQSVRMVGADGKVRIVSATSHPDLWWGVLGAGANFGVVTSATYKVHPLVNNGDVFLADFFLPASRSREYFDMVETHYSNASANVAQIVIGSWNRTTNSVQVGGNWVYYGSEEDARKELAPVFNLNATSVTRVVKWNQIINRSGGGFDKFVCQPNQPRSLYSLNQKIYSADGYQRGFKKIEKYFHDYPGGRDTTLVYETFPNQAVAAVPDDSTAFPWRDFKGFIQTNFAWAAGDEVTAKASNKLGEELRNDFAATSGYSEQTIFVNYARGDESIENVYGKRKLPRLARLKKKYDPSNLFAYNHPLPTQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C112</accession>
    <name>A0A2T4C112_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1471019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C112"/>
    <dbReference type="STRING" id="983965.A0A2T4C112"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="58"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="792" mass="89426" checksum="2D6C36FB4CECCB90" modified="2018-07-18" version="1">MSTACGERSEDMYSYSPLQGPRHIRLLRLLPDWNKNAPLRCQLFEYPMLELGDGTHMYEALSYVWGSPEKPYTLYIDEKSMPITANLHEALLRLRNRMIERVIWIDAVCIDQSNVDERGEQIQHMAEIYSKASRVILWLGEAADESDQALKRIRMAADEDQQESLATKEDRQAILAIVRRPWFRRIWVLQEVAAAQHIVVMCGSMSIDGYAFCLGLPSLLPYEDIPSHIRSVTYLMRGSIFRPKYSINSSGAISLDVRPLGGLVDLYHTHEATERHDKIFALLGMSSDNPGASGLTPNYSITWDELMARLVKFILGERVHVWSWSQHQAAAVFAKGRVIGIVSSVQMVKDDTRGDRQHVSIKMQDILGPAWIVPGAVKPIQAGDIVCHLLGATNPMVLRPRSDYFTIIMVQVAPPSNTGMESMKPEQSDQPDSSSVHDFVLVWDWETSYEKTQHHDYETWSASRIDQSPQLNKAQLGGYVDKQTRLWNVALIMSDAGSNEESVVNMLEDMKNACISNSGQLNLRALMCMSKLALSYGRMGRSWEAEVEFWRMFWAMRSTRQAIGDGELIGELASFGAMCKNHGHISKARKFEKIAGLLRMARQHPILEDEDFAVVLAEASVRDVEISEKVVTKAEKRFRGIKNTNGASSQRRYAATPLDVLLARAVWKGNVEATYLLLSHKKAQVTEEVLIHAVRSRDSSALWCILGREKDEILIGENIVITAAKKSNESVLQYLLERHGDKVLITEEVLVAAADNQERSVLIYLLGKWKHRFQITERVAIAAAENEEGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C158</accession>
    <name>A0A2T4C158_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1272495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C158"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015697744" evidence="3">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="277" mass="30153" checksum="0B1E8F3EB8207D36" modified="2018-07-18" version="1">MPLALAGWLCLSLYVFSCACACVSLASLPPSLPLLCFYLLRFSLLLFLSFLTHTEKQTVTGGPSSRSRRIMHAASPVVPSRSRGLPQRNAQLKPPKPHMSLFAKPVTAKREKAPPRESVLENVRPKHGCQSQKGKIRHQSDTSPPVMPCLCPRHTDCPASLLHSLASPAAAALPNESLYGLGMTRLAPAAQANPSQNHALLFTRCPLELPSCLSSHVTGQRDKETREQTEPVTRQGGCVSAIRMVVCSAANELVGPTKPGRRRIKAKYAVRKWKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1D8</accession>
    <name>A0A2T4C1D8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1458850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1D8"/>
    <dbReference type="OrthoDB" id="5422061at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="371" mass="41879" checksum="34A19DB37254E289" modified="2018-07-18" version="1">MLQKLQIIPGNLHTVPQNLQRPPCLPPAIQVLHQAIGSGLNMFRVNILLPGTIYLLGNIHFQANIRLQVYGQSQANIQLQANIRLQANLQLQVNMQLQAQCHTLLQANTPLLVNIRPICLRILICLRTITCLLILILTRLQALILLCPRAIIRPQTLICLHTLTLTLMCHHTLILRWRLVHIQPQVHMHRGSYSKNCRAHPRNRGSKTTDRSSDITDHGSDTTNRGSNTTDRGYDSANCISTPGTAPQSPRTATPGSGAAAPTPEVEDPNSENASGYKVPKRVHRVERTFSIEKKISVLTFLQQHRIPADKKPCRVKTGMEEVERNQEQQGGKFFRTPTFREAAAHFQISSTTIATWWKHREKIMAKERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1K8</accession>
    <name>A0A2T4C1K8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1402950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1K8"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29253" checksum="0BCB900CB23B03DF" modified="2018-07-18" version="1">MYLRSDHAESDLRVLRQLIRENPLGLFTTAIASPSYPFLQSSHIPFVLDIDDESSETELGRLRAHMARANPQAKAIIDDIKRRQAAGDSSPTTLQQDVLVMFTSSVQHYVTPKFYTTTKPATGKVVGTWNYAAVQVYGKATFYIDANAEETTGFLDSQIDALSSFNERVTMDYTGEGSRPKPWQVSDAPAAYINVMKKAIVGFEVKIERMEGKFKMSQEMGAGDAEGVVKGFSELGSEVGTKMASLVEERREMARQKKASKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1P7</accession>
    <name>A0A2T4C1P7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1255483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1P7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="193" mass="21370" checksum="8E709A86EFD7805A" modified="2018-07-18" version="1">MLARLICYMQSSQVRAPRCGKGASRSTWNPMAHCPGLATGGERTISHHTRCVRYIDVPSVEHLQKVWDLDASEPVAVQDCVHDMRGRQNDKAPASFPSDLSLLSLLFHRWASLRLLFLLGLSLKAEPSAAGNISCLIQSHSRGVMRAGVTGIFASLVKSLRVNPILLRRVIRQHINRATDVNDMHLCLNTLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1W8</accession>
    <name>A0A2T4C1W8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Longevity assurance proteins LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1377959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1W8"/>
    <dbReference type="STRING" id="983965.A0A2T4C1W8"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="67"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="382" mass="43700" checksum="1A95D3A2E2DAA4D9" modified="2018-07-18" version="1">MMPRSRVYTIPYFKLSHYNPDTGLYAIGRFDACFVVFFVVFFTGIRHAVMAFLLSPLAKRYGIEKRRDRERFAEQMWNVIHYSIFWPLGIYIWSTSPYYLNVAELWTDWPSREITGTTKFYFLTQWAFWIQQLLVSLIEKQRKDHWMMMAHHLVTVALVAASYSYHFTRVGNVTMILMDAVDIVFPLAKCARYLGYKRVCDGLFGLFVIVWLATRHVLFSMVLYSVYFDARSILPHACYRGSMANLQGPLPQPQGWSWLLEPFTQPQGIVCVNSGILNGFFAYLAVLEGLMLIWGYSILQVAIRVLGGHNADDVRSEDEEGADDDLPRELEGLNPADYEQFDGGATKAWNCGDRLSLVRGGISSGLSLAGQSEHKELLSRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Y0</accession>
    <name>A0A2T4C1Y0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1335039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Y0"/>
    <dbReference type="STRING" id="983965.A0A2T4C1Y0"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="207"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="417"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="586" mass="63431" checksum="AFD4B8D3D1B9BA03" modified="2018-07-18" version="1">MYTASSAFFEALWEAGVTHCFVNLGSDHPSIIEAMVKGARERKGNFPRMITCPNEMVAMSMADGYARLTGKPQCVIVHVDVGTQGLGAAVHNAACGRAPVLVFAGLSPFTLEGEHRGSRTEYIHWIQDVPDQKQIVAQYCRYTGEIKTGANVKQLVNRALQWAKSGPQGPVYLYGAREVMEQEIKPYQLRQSDWEPVKLGSLPKPAVDTIADALAGAKRPMVLTGYGGRNHEFPGALVELANIVPNLRVVDCGGSDMCFPFDHPASLGLNYGGEKSIADADVILVIDADVPWIPTHVKPNPDAKVFHIDLDPLKQQMPVFYIESQATYRADSQLAIEQLTEALKSGEHAKKLQAQDVAQIADKRKKEHEARLAKIAKAAEPRPDDSFGTGYLCRQVKKLVPKDTLWAIEAVTNTVFVYDNIQPSTPGSWINCGGGGLGWSGGGALGMKLASDAESGGKNKGKFVVQIVGDGTYLFTVPGSVYWISKRYNIPILTIVLNNKGWNAPRRSLLLVHPEGLGSQASNEEINISFDPSPDYAGIAKAAADGDIFAARVSERSELEDVLKRAIAHVENGQSAVVDVKVATGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C267</accession>
    <name>A0A2T4C267_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1301668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C267"/>
    <dbReference type="STRING" id="983965.A0A2T4C267"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="208" mass="21646" checksum="9E906BD1783A6F7D" modified="2018-07-18" version="1" fragment="single">MAAIDSTATQATTKPAVPVVTSFPFNPLTTTFTRPSDCDGIFASSFLSGIDFSTSCVPKGFHTDETSYFSPGLVCPSGYYSACHDNIGARTITTVTCCPTYGSDVSLSCVTASTLRSVWSTLFCTWIAPDGDGTALPVTVSNGGTTSTVQGAFTAPGGLNAYGIRMVYQKSDTETTTMATRTSSPTRSRATTTGRPEETSEGSSHGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2A4</accession>
    <name>A0A2T4C2A4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1439353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2A4"/>
    <dbReference type="STRING" id="983965.A0A2T4C2A4"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF6">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="306" mass="33816" checksum="1E315E8599A566EF" modified="2018-07-18" version="1">MASNILVLGAGELGLAVLQALSRHPKRGHARIAVLMRQASLDSAAPDKKKLVQQLRALDVSFEAADVVQMSLQQLAAVFAKYDTVVSCNGMGLPPGTQTKLCEAALEAKVPRFFPWQFGMDYDAIGLGSSQDLFDEQLLVRAMLRGQNATDWLIVSTGLFMSFLFVPDFGVVDLAAKTVRALGSWDNRLTLTAPEDIGRVTAELVLDPQGLKNQCVFVAGDTLTYRQLADLLDERFGVKFRRELWDAEELAKQMHEEPSNGYVKYRDTFAQGRGVAWDQDKTVNVARGIKMKDVKAYLAAMDEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Z0</accession>
    <name>A0A2T4C2Z0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1439510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Z0"/>
    <dbReference type="STRING" id="983965.A0A2T4C2Z0"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="75"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="914" mass="100418" checksum="8F0D9356FF7B9742" modified="2018-07-18" version="1">MSDYEDEMDVDGPAPSADITFSAEATKGKRSAANLPVEAEDTLPWVEKYRPVTLDDVSGHQDILATINKFVESNRLPHLLLYGPPGTGKTSTILALARRIYGTANMRQMVLELNASDDRGIDVVREQIKTFASTKQIFTMGGGGASKGSSIAGFKLIILDEADAMTNTAQMALRRIMEKYTANTRFCIIANYAHKLSPALLSRCTRFRFSPLKEGDIRVLVEKVVEEEGVNIQGEAVDALVKLSKGDMRRALNVLQACHASSTPLRLKNEPKPPESEIKRETITTETIYNCIAAPQPDAIKEIMETLLSTPDVTSCLNTINALKTTQGLALADIITALMEQLTKLEVSAEVMITWLEGLAEIEHRVAGGGSEMVQTGAVRVARLTYKYHGIATSVIKIDCEEELNRLRPMSASPRGAAMLSASPSEAASTAGLPMHAQANAEFHKIPQILPRERVFPIQIGGELFKLSGASISSDAPSYFSQYFLCQIKAAESKGEDPSSSIRTLYIDRDPATFRDIALHLQGYHVKPRDGTHFVRLFADAQFYNLPKLISQLNEESIFISIGHREFQIPRDVLNDPANSPNYFSLGFALFFSQPNDLFPGLDREGLIRPPSILPPSVPNRNADTFAELLRLLRGYPVSVRDEAHRQELLRDARYFHFKGIEQQLVPHCISYNPLRQVDEIVLRLENVQKSGVSISVPEDFDGAFRSSVRHVRYARPYVDSKPAELILEIGGTTTKLNFTAEGARAEFFGGTKARVARLLEVVATKLNLPPTTQPLGLLMASGGASSQPATPGNTPLSEDLVRVVFEAESAITLDGQDYEGDLSGYTDDDATPAITPDAEALANPRKRRRTGESVDIGLPDEGRQWAVKTGLFRLRIQESKGGKSAVECAFVAVKIDAVSSERGRNKMRRFLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C305</accession>
    <name>A0A2T4C305_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_332863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C305"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="286" mass="32457" checksum="FFBA56ACFFE525C6" modified="2018-07-18" version="1">MDDAGERRASPSPYDGAPRDANTPERLGLNKVERRPDSASAMIALFRACISYSSSYFFIRSAMPGAAEIRWSFFAGLQDRGHQGSHHTFAPAGLKKKTLRTFPRQSLRTPFSLNSLSSQSLRPDTRWWLSVPFVQRLRNISNALETFDFEALLDLTGPCSTASFFSLAALRLSRPLPSLLTTCLSQFHTVHCFEHQTSHFEEAIYRPSFHLLRVLKRLSHRVEHSSFLPAAEARLAELSDSAQHFGRLGVLRAFQRVFDHFCHFQPLPHISSHLLLSKSEFPSPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C378</accession>
    <name>A0A2T4C378_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1334477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C378"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22143">
        <property type="entry name" value="F-box_ScMDM30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="453" mass="52602" checksum="B38913DD06EC196E" modified="2018-07-18" version="1">MTALLDCPAEILHSIFEHLPTSSLHALCLVTKRLHQVAEPLLYTRIDLIWERHRPPPIISLLRTIQNRPQLATHVERLTLHALSEFDVPGGFGYRQLPCSIPTDGTDLAGFIATIQDIDSPLRDLWIQELQNGTMDAFVMLLLSYVRNITHLRITGVFARANRLLGMMLRAALCQDLHCRLPWLHSLQDVVTEPGWTQYRYNEPKNTADILPMFYLPSVRSITAEIDNPAIFAWPTYAPNPSHITTLDLKIIREGHLGRILATTKNLKVLKWRWEYEQLLKDEFNSDVIKLDQITADLTFVKETLECLHLSAMFDNEYWRDTLTVTGSMKGLRNFERLQRLEIPQLFLMGFSPVDNLGCFKDLMPKNIHHLVINDDSIWLEGLAWQDRDLFDKLERWWDGNMHHTPWFTSFKLSLEWTDEQWCAGLRQELSDLCARLGIQLEIYKELKDLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3V3</accession>
    <name>A0A2T4C3V3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1356011</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C3V3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1012"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1102"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1199"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1226"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="405"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="617"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="937"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1289"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="873"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1562" mass="172782" checksum="9FA6A8CCD6361DEA" modified="2018-07-18" version="1">MGLGFQPEHAAIALTSLIAVLSFSSLRKLTVNSRAQQRRQDGRLYEDEDGAASEDSIARFSNKKQFITIFVINILAIVLAGADAIFTAVQHGFAFPGSGVPLLDIYLLVSAWIFLLLQLLVASREVAPIERFNSVTSTLWTSLFIVCIASVDVHVLNGLSHRDNAGLLTTSILTAAQIVAAIALMATICTIQRRPDVFRPNGRIVDSQKTLSLWARYSFEWGLGMLRAAGTEKFENSDMPAMDHVVRSENATANFKDIIFKPDRLPLWAHITWKYRYQFLFQWSATLFTNFFDVAPAFANLQLLRYLESRNNLDVIDPVAWIYVAAIVIATISSRMVDSRVMWSEMADIVIPLRSTLTGLMYEKLMRMEDSLHIPKDEKPSGPDAAGSEDTEEQDKQPNMRSQQDIVNMFSVDCDAIARFGSQSGQYINCAGQFLIIVIFLLHLVGWQSLCAGMLGILVLFPINRALAARYGANQKILMKLRDKRSAIITEALHGIRQIKFSAIEAQWTDKIEQVRERELQMLWKTRINNFYMAIASEFTPIVLTALSLATFSYINGTLLPSVAFTAITLFMILEGIVEHIPLLLVTAINAKVSCDRIDKFFRNPDKKDNTHPGTAVSFNDATVTFPSGSDDLAEDRFALRKLNLEFPNNSLSVISGPTGSGKSLLLASILGEAEVLAGYIQVPKAPPPEQRYDSKATAANWIIPTAICFVSQIPWIENATIKDNVLFGLPFDPIRYDKVLQACALSQDLSLFEDGDETEVGAQGVTLSGGQKWRLTLARALYSRAGIMVIDDVFSALDAHVGKHVFANALLGELGKGRTRILVTHHTSLCLPRADYAVHLSAAGLVEHAGPVEELRRTGILEHIIEADDVEEVQRDADADPKRPNGVATSPSQNAVPKAAKPPKKLVEDEKREVGRVKTSVYVGYLKSFSGLPFWVFLILLFAVAQGLTLGRTYWIKIWSSSSEQVDNSSSIPVYQYRHTLQTQMFGQSGNYATSTKASVSLQSDAQTKNLLFYLGVYCLISTVSVLVSVSRLYCVYAGSLRASRRIFRGILRSVLRAPLRWLDTVPTGRILNRFTGDFTSMDSSLATNFYYFATVTWEMLGIMVAGIFVSPFMIFIAILLLVACAHYARRYMVAARTIKRLESTNKSPVISHFASSLSGLSTIRAFSKGPEFTRRMFALIDDWAACSWYITAFRMWLMLRIGVTASMFAAVVGIFVVTTPGIDASLAGFVLSFALNFGHAINWGISVSTQTELDMNATERIFEYANLEVEREDGEDVRASWPEEGRIEVENLEVGYAEGLPSILKGLSFTAERNQRIGIVGRTGGGKSTFSLALFRFLQTRSGTITIDGVDISKIKLHDLRTRLAIIPQDPFLFSGTIRSNLDPFNQFSDYELQKALVRVHLVPSTPGTPIPEAILDESSSTTVTENGSETNSALTLSSPVASGGSNLSQGQKQLLCLARAILSRPKILLLDEATSAVDMATDRLIQQSIRQEFSDSTLLVIAHRLSTVVDFDKILVIKEGRTAEFGTPKELLEVEHGLFREMVSQSGEKDELVRLISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C431</accession>
    <name>A0A2T4C431_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1439021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C431"/>
    <dbReference type="STRING" id="983965.A0A2T4C431"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="743" mass="85018" checksum="EBBA4E7CC7D9B85E" modified="2018-07-18" version="1">MSSIRKAGGMNEGPHRSVRRCLGKQSRIRIDRANDTGWEGNVGERRDDAGDAYDMLTVFCSDKDFDGHYSHFCKQMLWPVFHYQIPDNPKSKAYEDHSWKYYVKVNQAFADKIIQNWKRGDVIWIHDYHLLLVPGMIRKKLPEAKIGFFLHVAFPSSEVFRCLAVRKELLEGMLGANLIGFQIQEYTRHFLLTCSRILTVEATPEGIQLEDRFVDVVHSAIGIDPVSLNKHREENEVKKWLAIMQERYQGKKLIVARDKLDHVRGVRQKLLAYELFLNKNPEWRENTVLIQVALSAGEPTELDAAVSDIVTRVNSTWANLAYQPVVYLKQDIDYAQYLALLSIADALMITSQREGMNLTSHEYLFCQDGKIYPNKKHGSLILSEFTGTSSLFGRNELSVNPWDYRQCADAIKQALEMSEEEKTRRWEKLYQSVAHQTGSHWFTEFLSHLDRSYEEQHKRDQTYVPRLSMSSVTAKYAGSQRRLFILDYEGTLVSWGPVNQIIPVSPQRTLDVLNDLLLDDRNTVYVMSGRRPEELDRVFRRVPNLGLIAENGCFLKDCGSEEWVAMADADQITNWKESVKPIMQYYLERTPGTHVEERRCSLLFHYNNAEDYESASRQASDCASHVNDACESLRVHAVATDGAIVVEPLDWTKCTAAQRVFEQLGEHMKSDETHKQPVDFLMVVGDGREDEKVFRWANNLGDQNQIKNVITVSLGSRSTEAAATLTQGVSGVLNCLQRLASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4R0</accession>
    <name>A0A2T4C4R0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1457502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4R0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="241" mass="25704" checksum="7E44C2AEC3260A73" modified="2018-07-18" version="1">MADPPATKQVVLVTGGNQGIGFEIVKKLVAEQPTYHVLLGCRSLSKGEDAILKLEKPAGSVTPVEVDITLSAHGKLDVLINNAGIGRHAVEELPSLRAKMAALFDVNVFGTLVMTDAATSLLQKAADQGSVPRIVFITSEMGSLGNTLNPSWKCYQHNTSIPYKSSKAAANMIGACYSTLFEKQGWKINCCCPGLRKTAFNNHLAVAMDVEEGAVRAVYLATLDRDGPTGTFANINGTEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4R4</accession>
    <name>A0A2T4C4R4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1392028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4R4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4R4"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015629104" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15960" checksum="C9E9C8F096788380" modified="2018-07-18" version="1">MFAKTAVVLLAAAASLVSALPEPTRVRSAPEAKRTEHFGIGTVYDQMGAFGSCGEKHGDDELIVALTPSWQGNGFPPKYCGRKVFIQNTGSNDGVGGAGRTVIATVKDTCPGCPTADSIDLSHGAWNQLTNFAPFGTINIEWHFCNENGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4W9</accession>
    <name>A0A2T4C4W9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1230333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4W9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="16092" checksum="940EBFA97E2602B5" modified="2018-07-18" version="1">MHRWEPLLQRQQTQQTRATLRSLSLLQPLSLSLTSSTDQQRSLRPRQTSLCVTTCPVAAQFLLRSLFDTPISNPSGGPEGSSSRHKHLGSSQVSGEANQPKHLHHVRPCFSVLCDAGVFCRQPFYAHQVAFHDRCLRIFQFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C575</accession>
    <name>A0A2T4C575_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear membrane fusion protein Kar5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1438458</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KAR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C575"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43811" checksum="00B4C19733FB94E9" modified="2018-07-18" version="1">MYATALNELQELESEPLCHRTAALLLVNNCQLLDGRDEATILTDTGRAARDFVDSYAASLAICDLERGSFVIPSSCSKFQESFLARMPPPTKPQLHVTTSEIDACLEGMAQSDSAWNTWVSYRHKTLRFCEAARADNEKDQNIRVHQRLTSILAKLTTQLEEEMEERLRSMNHMFQEAGATMESLKPRMKDLQDGITQLDALFKDQIVQNVQQSADFVTHGLDDARQLQMLLAMLVGVAQKQNRDLATSHGATLQEVSLRITSEVDVILAALAAAVASSSSLHREIEISQSAAAAVALRQEKIETGMQKLEGLADSLLAKHKAHKERLSDAQQTASDLIDILDSASTSAVTLRSSLYNSFGWGSWWPYVFCPLTSLVVGSYGLPPSATRNVVLISLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C595</accession>
    <name>A0A2T4C595_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BIR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1232329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C595"/>
    <dbReference type="STRING" id="983965.A0A2T4C595"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="95293" checksum="E61CB37C69B8B632" modified="2018-07-18" version="1">MASESHQYFTYEARLASFQKPTKKRGSAAGGRAAKAFSWPHKQISITSLARAGFVFKPSPESPDNTVCFLCEKGLDGWEAGDDPIYEHVKHAPHCGWAIVAAIEADIGDYGREDPNDPDMVDARRATFADRWPHENKKGWKCKTKQLVEAGWKYTPTEESDDMATCTYCQLALDGWEPGDKPLDEHYNRSPDCPFFALVSQYRALGKGSGRARSARNSASSSQSYGTAAVDMSNASDLSASLDDSVGTTASSASQLGTKKARAKKGAAAKAGRKKMNEDEQSEGLDQDSQVEEPRPPKVRRGKKRPSDAVEELATSSGDGPISKKRSSQALGHDTIDDLAARDDDSEMTDVSRASYSTDTARARSKAGRRVASKLKSHASMASLRAPGGFPDDDEIERQLEVDLEHQLTDDEIAHHSDAGRNKARAGPDSESAAVRPTGPRPPKYAMFDPVVPEPSEDEIDDDLKALKAEMQVEEPLEVPKKGRKAGVRKGTKQAKAQNAKPESLPQERGTESDIPKSQQEDVLASAEVSETSTGSVVRKPAPAAPGKRGRGRPRASLPSQDESVDTEATESSQQSLKRGPGRPARVSLASLLSAEVDGANPAEPPAKRGRGRPSNASSATLDSTGADADVEAAPRPAAKRRGRPSKTTAAPLLARQEGTAAGKRGRGRPAKKPVEVQPAEPVETEAEDDLVEARELPEVPVRLPKQSPIRAIFSPKGKESLVPLPGTPSKLSPAPSARQPVLSPSQSPQSSDAENQPPASRGLIGSAAKRLVLAPVASTPPPGSPSKRNVMAGLRSTTPWASASLEAIFESPLGSPGKENEVDRFLTRGNELTSPERQMTVEEWIYFNAAEAEKKLKFECESLVNRFEMEGTRAIRVLEGLEVESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C599</accession>
    <name>A0A2T4C599_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1421833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C599"/>
    <dbReference type="STRING" id="983965.A0A2T4C599"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="308" mass="33322" checksum="CBA056E6ADED7AD4" modified="2018-07-18" version="1">MTVPSNQDFKIPYRVISITNKTHRTAYPAISPSRPALSQAGRTVLITGGSGGIGYGIALAFATAGASRVIIVGRDEVKQRAAAESLARDAGPGSHTKFEGRAASPASPEAIDALWDALGAEGILVDVLVLNAAVTGNVVQDSLWTAGWESIWEKFIVHVRSINHYSERFWKQNENKKRYIVNVSTSAIHDFEAGEATKAYALTKNSGMLLMQQLARDTPVDKMQIVSFHPGAILSPGAKSGGADENSLNWDDISLPSSVAVWAASDEAAFLHGRFIWSAWDVEELQKGPLRERIETDDKFLRIGVHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C627</accession>
    <name>A0A2T4C627_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1681-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C627"/>
    <dbReference type="STRING" id="983965.A0A2T4C627"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="88" mass="9346" checksum="F679F700A219553B" modified="2018-07-18" version="1" fragment="single">TKDYSLKEGETITVNLGGTKFGRRRPQNAEESSTSSSSGSADLQSFALPPPPAGGFSLPPPPKTSDVKEKRKSLKNLGFDDGQFGEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6H2</accession>
    <name>A0A2T4C6H2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1400089</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6H2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6H2"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="210"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="413"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB77177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="573" mass="62873" checksum="F93D5E0BE54E54F3" modified="2018-07-18" version="1">MANIREQSLEQPMDVAEYLFRRLHEIGVRSVHGLPGDYNLVALDYLPSCGLKWVGSVNELNAAYAADGYARVKQMGALITTFGVGELSAINGVAGAYSEHIPVVHIVGCPSTISQRNGMLLHHTLGNGDFNVFANMNAQISCDVAKLTNPAEIATQIDHALRTCFIKSRPVYIMLPTDMVQAKVEGARLKQPIDLSEPENEPEKEAYVVDVVLKYLRAAKHPVILVDACAIRHRVLDEVHGLIEKTNLPVFVTPMGKSAVNEEHPTYGGVYAGAGSHPPQVKDIVESSDLILTIGALKSDFNTAGFSYRTSQLNTIDLHSDHCVVKYSTYPGVAMRGVLRQVIKKINPSELSVQPSPKVENEVTKNLDNSPVITQAWFWPRVGEFLRKKDIVVTETGTANFGIWDTKFPSGVTALSQVLWGSIGWSVGACQGACLAAADDKSDRRTILFVGDGSFQLTAQELSTMIRLKLKPIIFVICNDGFTIERFIHGMDASYNDIVQWDFKALVDVFGGSKTCKKFVVKTKESLEQLLTDPSFNAAECLQFVELYMPKEDAPRALVMTAEASAKNNAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6S3</accession>
    <name>A0A2T4C6S3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1206817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6S3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18914" checksum="BC2F9F8FD39CF99C" modified="2018-07-18" version="1">MSCALFISKVELGGKLSQQFPFGPGGRSSLTCTRYFWLLPETVSRREKYYRSLKIDTRRSLCCTVMVQLIHYTIFLLKGKKRGNEALQCYQYLLRSRGQFYPEMPLQIGGCTSTLSSRWKKKSYVPLNQEQELPTIDFELLPSFTQTRHCLAIIWFDVDGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C786</accession>
    <name>A0A2T4C786_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">M440DRAFT_1437954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C786"/>
    <dbReference type="STRING" id="983965.A0A2T4C786"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="178"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="384" mass="43809" checksum="4AD1E4A56036049E" modified="2018-07-18" version="1">MLHTLIPLSGGQDDLVRFIDLLYMDMQDYAFEPLPELERSFANATKATEQIANLLTQDEVVNGLRSDKVANLEFLKNQHGVTIEMVNALYDFGQFQFRCGQYGPAADMLYQFRVLSTDNDKVAAATWGKLASEILSTNWESAVDELKNVREGIDTRLFNNPRAQLDHRTMLIHWSLFPLFNFEGAREPILDMFFSASYINTIQTACPWILRYLIAAVITGRTRARNSSVQQKQLKDIVRYVRQEAYEYADPITQFVNALYIAHDFNAAREALRMAEEVCRSDFFLAASTDAFVNAARHLICESYCKIFSRMNIRDLSAKLGLNPDDGEKWIVNLIRETRLDAKIDSQDGTVIMNHPPNNVYQQVIEKTKGGFFRTQVLNAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8D7</accession>
    <name>A0A2T4C8D7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1462392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C8D7"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001433">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1095"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1126"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1168"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1235"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1320"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="74"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="692"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB77826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1353" mass="149805" checksum="FE2B15917F255E7B" modified="2018-07-18" version="1">MASMVGEGDVEKAELASMTDMSLDAPISRNKLDRNRFSITGAANLSLDDVEAVHVQLRGLAISVDTSPSWLDPSTYPELFSAGFKTKPRIKTLLHSADADLKPGALTAIIGGSGSGKTTLLNNLAERVVSSRLSQQGLATFNGKVGVNSVRHAYVMQQDILLPTLTVRETLRYSADLRLPPSTSAEDRERIVEEVILELGLKECANTRIGNSQHRGCSGGEKRRVSIGVQLLANPSVLFLDEPTTGLDATSAYQLVRTLKALAQKGRTVITTIHQPRSEIWDLFDNLIVLSRGSPVFSGPASDCLPWFEQLGHQLPPFVNPAEFVIDVAAVDNRTPELEAETSARLEHLKAAWKTESERRFPPLDDTAEVRTRNKHPQAATHAGFLRQVRILTDRTFKVTYRDPLGMTASLLEAVIMGVVIGYLFFDLGRDQAGIRSREGLLYTATGLQGYLILMFETYRLTIDMPTFDRESSEHCVDAVPYILSRRLARLITEDFPVPFLFSLILYFMAGFDHDAAKFFTFFSIGFVNHFACIMCAFTCVVAVRHFPGASLIANFAFTLQSIACGIFIQVDTIPVYVRWLKWVTWSFYTFGAYCGNEFQGSFYDCPEPGGPSNPACLQYTGEYIMSSLGFPRNWVARPIVCLASFVIFFFILSAVGLQYIKVEMTIARARVSNTDLSAGKEKMTARSIAEVRTIDVELENFSLDLDKRKMNGKKLPRKTIVQPINVNFQAGTLNIIMGPSGSGKTSLLNSMALRLRNSIGTHYHPSGKMSFNGAVPSAAVIRSVCSYVCQDDDALLPSLTVRETLQFSAALRLPSFMSKEEKHRRAEEMLMKMGLKDCADNLIGNDLVKGISGGEKRRVSIAVQVLTDPRILLLDEPTSGLDAFTANSIMEVLQGLANEGRTLILTIHQPRSDLFKHFGNVLLLARGGAPAYAGPAKDMLNYFNKQGYQCPQHSNPADFALDMITVDLQRDDREAESRGRVEKLIEEWRRYSSRGDPEQMRKREDVSRLPEITETDELDEKKASAEGVNDVVADTGEDLSKIQPAVSRKSFNKANLSTPAELGALVHNSASITTAVPLLLHRAIINTRRQPQLIMARTMQVVGLAIIFALFFAPLHHDYYAVQNWMGFIQEIGAFYFVGMLQNVAIYPSERDVFYREDDDGVYSVDAFLLSYTILEVPFEILSCLLFGILMCIAVGLPRTATMYFISVFGCFGIVSCGESLGIMFNTLVNHTGFAVNIMGMFLSIANAMAGVLSIDAPEAFQALNYLSPIRYALRAIAPYALRDEHFYCKPGQQLANGTCPIETGKQVLQLYKFDDDPVVNVAALAGCLVVYRLLAWLLLRLARARWGGCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8E1</accession>
    <name>A0A2T4C8E1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1223612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8E1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="334" mass="36436" checksum="E2909D1E41C1B729" modified="2018-07-18" version="1">MKHDFDHSTAARHTKGRKGRARHSASLPSLQAIHTHALTTEDSPHPPATGRQTLETSDCSNPSSYQPPIPGHQGRSTRMKEKESRQSPSPASPGHIIPGPSHSSTPRARCCSNGKLTSWAPSCLVFPVQLVVCLSPSPRSEFTSGRSKRQHQRQTLLCAFCFVRHLPLILVHAPGIAMDLNSIEIHHLVRVAVGCNSCTPPLPLPPPGPLCRPFPSHLQSAAAAPSCQTDNPGLQALTAQSPPRRPRHSFFFSGPPASNSCQLLTGCHITRLFLRPWSHLPLTTWLLYQGKTVEDQPPPGGIHHNIRHRMAPSGSRILLSLPNLRIPRPLLCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8H2</accession>
    <name>A0A2T4C8H2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_293414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8H2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="149" mass="16927" checksum="6E3505A45CC48C68" modified="2018-07-18" version="1">MYAEPTPFRSQRSGLFSSSSHTPLLPSSIFAPPPRIKTARHEYSGIGRARPVASPGYIRLGGRLFCLFSSTSLRPGTSLRPFRPFFTRQLTFQRRQPLLHLHQPCRETTCDLPGSRTGRRRNSKRLHSGEVTHRARRSHDFGFHCSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8I8</accession>
    <name>A0A2T4C8I8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1354381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8I8"/>
    <dbReference type="SMR" id="A0A2T4C8I8"/>
    <dbReference type="STRING" id="983965.A0A2T4C8I8"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="34301" checksum="F42BBF708CA6276A" modified="2018-07-18" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8N3</accession>
    <name>A0A2T4C8N3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1375601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8N3"/>
    <dbReference type="STRING" id="983965.A0A2T4C8N3"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="104" mass="12208" checksum="DB59A525E3CD937C" modified="2018-07-18" version="1">MNPGIRLLPLGLGRGYATQRPASRLKPTISLDHFLQRSRALSLYRTILRGTRRIADPRTRAESRKYARDEFERHRHVQDISHIRYLLSTGKTEWESMERYIGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8R2</accession>
    <name>A0A2T4C8R2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1227998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8R2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="191" mass="20559" checksum="E9461D066BD783DE" modified="2018-07-18" version="1">MAPSCTQTAKGSRRSPCRAKASTGWVPASIPPLDSRTMDASCLFCPSSLIRHAGSRLGSPCSSPRSDPFRPACLISDPWPRRDKGTKEKRAVLRATGPTGSFSRRGVTAWLAISAAQCSQTTARQRHDTTRHETAAGDSTAAACAQLSLVCRLHRSRAPPQTVCRVGSRPSAHWSHRPSSPFLALHPPWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Z5</accession>
    <name>A0A2T4C8Z5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1329554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Z5"/>
    <dbReference type="STRING" id="983965.A0A2T4C8Z5"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41221" checksum="09D566E53530BFC1" modified="2018-07-18" version="1">MASTCGPTCPTENGFFANGLNVGGGAVFLAAFASLTPATFYLGYRFRTPGFSAMLATGIAFEVFGFLGRILLHQARDRQGYFALMLLGSVLGPTFVSGAMSMVLPHLFAIHGQGRGPRQSILGIFFLWALFIGSFILNVAGIVFVAYGYGNRDRSADIVVGGLGAQALLLLAIMGAYVCFSTGLCLSAEALDPAHADIYHSTRFSRFLRCMEVAAILLFAHTVYRIFEMIGGLSGTLFQSESAFVVMDGLVPFFACLLLTTAQPGAAFGASWASTSPRYLKRRGLSLPPLQTSFGVGHAVHHRYDPNIRQQFSPSTQRPLREAKPPPTYGSYGLPSSPRPVNRPQSPMILSPISVRAVSIGRLSDRSDGWAAQGDLVDRDVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C935</accession>
    <name>A0A2T4C935_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_2639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C935"/>
    <dbReference type="STRING" id="983965.A0A2T4C935"/>
    <dbReference type="OrthoDB" id="5105291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20503" checksum="60DB62BE623BB985" modified="2018-07-18" version="1">MAICAVRATGKCFLCRSSSKLRTSAPWRNGNGEHSDPRLEAGDELVEANLPGHQSTIRVREALYICRFVTTFFNLLKEHWVAAVFDQLTARLIILDTIEGGRDKRAKAAGFGWRSFVLNVGFPCLFRVVSTPVAQQPNRWACGYIGLINVLLMKGVAIFSRHICWSTGILTGLLHAAQVEDNEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C957</accession>
    <name>A0A2T4C957_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1420232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C957"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="216" mass="24708" checksum="836E8CD7AE99FDF6" modified="2018-07-18" version="1">MAGTFYPFARLPTELRLRIWALAATPRLVDISARPTEVVRWKRIAPDDFSSPTPPPAMMHVCRESRRCAPYQKAFYTLVPGEPEHRYIWSKIRRLRLTIPPGSPGDLLLEVFSSMSRELMAPFTALRELHLAISEYFCAWGATWACSGFGPCARENVRFLDLSTGLLLTGPQLEMASAWEWQQGGRVMDMDDFDYELRFMLDNYTGLDLPELAKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9B2</accession>
    <name>A0A2T4C9B2_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1420323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9B2"/>
    <dbReference type="OrthoDB" id="4898817at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="66" mass="6629" checksum="057D0809D4D71E8C" modified="2018-07-18" version="1">MADNSPEKPDAAAPVVGSEDVPDSDSGAKVAGEGESAAKTADKSEGDAVMEEAKEAQACHRRTQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9E0</accession>
    <name>A0A2T4C9E0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chord-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1399358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9E0"/>
    <dbReference type="STRING" id="983965.A0A2T4C9E0"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="130"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="210"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="319" mass="35306" checksum="469923AFB264621D" modified="2018-07-18" version="1">MAQKCVRQGCGKEFTDPNEKCQYHPGPPIFHEGQKGWKCCKPRVLTFDEFMEIPPCTTGTHSTTEKPPPVEEGPQEFDEAALTQKISEASVSAPTRRPIQPAQHVPTPPPPPPDSEDDDPSLEIPDGAECRRKACSARYKKGSAREGEKCVHHPGVPIFHEGSKGYSCCKRRVLEFDQFMKIEGCKTKDKHLFVGSGKKDKAESGGEEILTSVRHDFYQTPTQVIASLFLKKINKDTSKVDIKEKEVDLDLTTSDPTPKRYTATFPLFGKVSPENSSFKVLGTKLELLLAKADGASWPVLRSDEQLTGEILQIGRAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9E3</accession>
    <name>A0A2T4C9E3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1329724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9E3"/>
    <dbReference type="OrthoDB" id="4156665at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17614" checksum="07C7350DD1901C0E" modified="2018-07-18" version="1">MHHRRLPSHHHNQSALRRRLAKNPELAHKLHQMALPLSPLVQLTTGAVHPHFPRTVLQFWLLTDAQLESLAHFYHQRTPSPWSRQYPCPVNWRSDAPLEEKRRKMGRFIGLRGCDSPTILLKTEEQIGRDASRNAADEDALRRKMNPFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAI8</accession>
    <name>A0A2T4CAI8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1399728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAI8"/>
    <dbReference type="OrthoDB" id="4874108at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="57" mass="6392" checksum="81D8798EFA33748F" modified="2018-07-18" version="1">MAQRLIACFQWIKTAGGKSTSLYTRISNRGAPYKKVVGEPTLARDHDLFNDNVPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAM8</accession>
    <name>A0A2T4CAM8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_265701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAM8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="15451" checksum="3DDE4D099ED147E3" modified="2018-07-18" version="1">MAFYSSFFLLLPQLRRHSSAVSPAHGYTPLGSTWPVFSSGPRECATSVTIGAEMPSRLFHAYTYCFILIILFLLFSADVSPAWKAADRWKSSFLRCSFASIRLFSVVSWRWRLVVRHGCPDSSNPSGSFDIKCQGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAQ1</accession>
    <name>A0A2T4CAQ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular lipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_49340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAQ1"/>
    <dbReference type="STRING" id="983965.A0A2T4CAQ1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="104"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="336" mass="35602" checksum="0F33EA1B3FBC9029" modified="2018-07-18" version="1">MPRARRNSSPLPSYETTTCLLTIYKEADSKSFTATQTDLTDLQFFVQYAGAAYCNTQTPAGQPIACANDGCPGVAATVINSFEGSVTGIGGFVAVDAAHQQIILAVRGTKNIRNFITDVEFAFEDCAFAPGCQVHDGFSKAWDEIADAATAAVTQAVAANPSFGIVATGHSLGGAVATLGATVLRGQGFPVDVYTYGSPRVGNDVYANFVTGQPGAEFRVTHVDDPVPRLPPIIFDYRHVSPEFWLSTGDGETVSYAVADIAVCTGIDNVDCNASTSGVDLTAHSFYFEKVSACAPSGLQFRRDDNSTDSGIDQASLDRIVKWSLEDQAFVASKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAZ8</accession>
    <name>A0A2T4CAZ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1454706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAZ8"/>
    <dbReference type="STRING" id="983965.A0A2T4CAZ8"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF1">
        <property type="entry name" value="ACTIVE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="676" mass="72781" checksum="691C41D9E239A3C9" modified="2018-07-18" version="1">MLHLERAAANGGATVSPPLPQVAGYVVVIGIGFLIAFIMMFATHLLKKTVGEDNRTTEMFMTANRSVGTGLTASAVVSSWLWSTAMLGSTLVGYNFGVAGPFWFAAGCSPMIVFFALLGIACKLRVPEAHTLLEIVRVRYGIAGHIVWIGLCLINNIIAIANMLLGASAAISALTGMHEIAATFLLPVGVILYTFVGGIKATFLTDYFHTFVITVLICFFTIKTFTVPEIGSPGGLYELVVQAGKRHPVPGNHDGSYVTMTSKNAILFGIIHILANFGLVIMDTGFFAKAFSAAPQAVVPGYIIGGIAYFAIPWCLGTLMSFSALGLENTPRFPTFPRRMTTDEVSNGLVMPYAAFAIAGKGGAVAVLLITFMAVTSTISAQVISVSSIISFDIYRQYFNKAATDRDAIRWSHIGVVFFGLFSAAFSTALFYGNVNLGWTLYMLGVLTCPGIFPTVFTILWKRQSRAAAVISPLLGMATGISVWLGTAHTLYGEVTVASTGQTVPCVYGTVASALSPGIYSIVISLVSPANYDWADFRKERLAFSRTNGSSDTRAAGDSKSPAATESGYLEDAAKFRKWGKIAAFWAAATFLGHWVFWPLPMYASHYVFSKGFFVAWIVVAIIWVWCTMLIAGFYPIIDGRKQILLVYRGLRGIRRVDEDSESGTETASSGILESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCD1</accession>
    <name>A0A2T4CCD1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1326511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCD1"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10476" checksum="EE8887A0F971E184" modified="2018-07-18" version="1">MRPSLALRAFRPTARMMRPVPKEDQAGHTVSQRLRKLKQMPAELYPLFVVVGFALGAAAYSCSRKFFVDKNLRLSRQGAAARAAQSHTGHGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCD8</accession>
    <name>A0A2T4CCD8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA double-strand break repair and VJ recombination XRCC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1164073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCD8"/>
    <dbReference type="STRING" id="983965.A0A2T4CCD8"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38325" checksum="6CCE270C6ECF5DAA" modified="2018-07-18" version="1">MAASRVIKLSRDDDESAYVLIQVVPNGPKPLDVKLVGTEGAAPYATTLKHDGVSSLRVKNCPISESEWQTILQSLFELQPAGDIQATADVKSGISLSITVRKRVQGITQRLGSICLRHNQNEGIELFEWCADSIDALTQSKEALAEATTRAKELESTVKELKAQLDELVTSKQEDETALLMKFRDLLNEKKVKIREQQKILATGSFQNSQSASQRFSQTVEPESSRAPAPSRPRKRKIESPRRDAEEAEEEDDLERDKIKTEPQDTDREDTAEDTASTASENDDDDDEDDDAGTRAGGSSKPTPKVPPPAKKAGEQPPAPRHLPFTRQAKAAPAKAPEADIETDSDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCY3</accession>
    <name>A0A2T4CCY3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCY3"/>
    <dbReference type="STRING" id="983965.A0A2T4CCY3"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29632" checksum="662E2A24751B8C04" modified="2018-07-18" version="1">MAPWQPLENASSINAYSDLQPHHHALVSRNLQHPTHTQAVTLGVIGGYVVAIAILWNVPYLRMILWPFKMLVIAFHEFGHAITAILTGGRVKSISLDPNEGGVTHLSGGISAITLPAGYLGSSIIGALLTMCGFDIVASKVASIALGVCFLLTLWWGKRDWLTVLTVLLAVGLLVGCWFIVHAEALRFVVLFIGVMSSLYSVWDICDDLILRKVNESDASVFAKRYGGSSQCWGVIWSIISLLVMAVGIVAGLAAFSQSFEQQEEDSKHFIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD69</accession>
    <name>A0A2T4CD69_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD69"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="79" mass="9491" checksum="6D059B63CED71E68" modified="2018-07-18" version="1">MCFSVEPKAKYYYQEEIIPARPHRHHHHHHHHSPRASYTTVDRYSHSHSHSPRVSSSSYRRSVPARVVYEEPTRVVYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE08</accession>
    <name>A0A2T4CE08_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_64669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE08"/>
    <dbReference type="STRING" id="983965.A0A2T4CE08"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="19754" checksum="EEEEF5423FC35E95" modified="2018-07-18" version="1">MGNTTSTVLDNIVQGSNFDREEVDRLRKRFMKLDKDNSGTIERDEFLSLPQISSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEQKLQFAFKVYDIDRDGYISNGELFIVLKMMVGSNLKDQQLQQIVDKTIMEADLDKDGKISFEEFTKMVENTDVSMSMTLGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE25</accession>
    <name>A0A2T4CE25_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear protein Es2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1399073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE25"/>
    <dbReference type="STRING" id="983965.A0A2T4CE25"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49012" checksum="DE82322C414522F5" modified="2018-07-18" version="1">MDSAAGSSSALVRKRTDRDLMPPPPLAKKIKRPKKVLEEDAYTEALSQIIARDFFPGLLETQIQQEYLDAIESKDAAWIASASRRLRNVMTPGRKPTRSASTVNATNGNQTPTSFVGDTPASIATSVAQDKPRLDLNLSLSAFQATYTSEDNESFYKLIDKQNQKRADKYAWLWRGNKLPSKQMIKQKEVTDRLEKTRSLVDDGFKRDLLAIRDVEERPARPDAWNAAPRNGLMFTPEGLEDGVKTIAENAEEQSRMAPRSISYENTRMPQPHVPQRPPSPTMSSIRDAIAGKPRQNDLDSNIVGGGETPRVNGYAFVDDEDGDDAATLPAPINLGPGDATNPFKIQDQRKREILHERMVERISKSKSDSQRRGFTGKAGAMETPRFTSGPKTSAGLTPAAQRLWSKMSTPLRGKAADTFGQATPRKPKGSLLKSVSRVPPKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE57</accession>
    <name>A0A2T4CE57_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1327708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE57"/>
    <dbReference type="STRING" id="983965.A0A2T4CE57"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="164"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="360" mass="41029" checksum="96F9B61F3781B678" modified="2018-07-18" version="1">MAALKAAAEAVDAVESAKTQPSNAENSPVETSKVETETEKSEARNSVPPHRSHDPANNLKRSDPFQFGSRYLEAGDDVFEFNAWDHVETDDAYKLYAEGQLEKQRQSPVSDFDKNRFNSNPAMWWNKFYKNNTANFFKDRKWLQQEFPILAEVTKEDAGPQLILEIGAGAGNTAFPVLANNKNPLLKIHACDFSKQAVEVMRNSEAYDTKHMQADVWDVASDNLPPDVEEGTVDLAIMIFVFSALSPREWAQAVRNVYRALKPGGVVCFRDYGRGDLAQVRFRKGRYMEENFYIRGDGTRVYFFDQDELAGIWSGPEDAEETGAPRFTIERLGVDRRLLVNRAEKIKMYRCWLQGQFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE89</accession>
    <name>A0A2T4CE89_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1468573</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE89"/>
    <dbReference type="STRING" id="983965.A0A2T4CE89"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="19">
        <location>
            <begin position="38"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="18">
        <location>
            <begin position="604"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB79848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="721" mass="80098" checksum="6999E495A90EB2ED" modified="2018-07-18" version="1">MSGRFLAASLRPLAARNTSAATNSSIRNILQKVGQSSSLTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGLNMVTRRPIELTLVNTPDSTEEYGEFPDLGLRKVTDFSSIQRTLTELNMAVSEAECVSHDPIHLTIYSRNVPDLSLIDLPGYIQVVGQNQPLQLKQKISELCDKYIQPPNVILAISAADVDLANSAALRASRRVDPRGERTIGVITKLDLVDPARGAAILNDKQYPLRLGYVGVVSKAPHSQGLFKMGSSDLLATIAKNEKSYFSAHPHEFGPEAGVNVGTLNLRKTLMRVLEQTMSSSLQSTSDAIRQELEEATYEFKVQYNDRPLSAESYLAESLDAFKHAFKQFTEEFGRPEMHELLKSELDQKVLDLLAARYWNKPVTDLTPAQHDLDNLADLPKADPDSLYWRRQLDASTSALTKLGVGRLATTVIASSLQAHVDKLLANSSFANHPFAKQAITEAASTILNERFYSTSDQVENCIKPFKFDIEVDEREWSQGRDHVVTVLKKELQDCEAALASLEPAVGGRRKLKEVMTFVDKARKGDITVEGDGRSGAGGFSAALLAKGREAVFLRDRADIIKMRMMAVKAKQCSNPKNKYYCPEVFLDAAATKLASTAVLFLNVELLSEFYYNFPRELDLRLGRHLSPEEVEKFAKEDPKIRRHLEVIRKKELLELVLEKMDSLRQLEGRDREHGPHGRRGGANKDRGRWGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CET3</accession>
    <name>A0A2T4CET3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_179344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CET3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="17865" checksum="C799FAABD4BA7002" modified="2018-07-18" version="1">MPSYHLSANKVTVSVKGSFVWADSIGFDTHTSTVTGAIGAVGVIGQARPPSRQHSTAAGWTVQRGMHARRSQNVRVLPLSPHARGTYDDLQTAQPVRIWLPLQVSGLDLRATAGLEGRVGRRWYVRTTNGPSAVLSAKQRPTPKPANYARRQSFLAAGAGSTKKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF00</accession>
    <name>A0A2T4CF00_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1325647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF00"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="12042" checksum="7B9EAF938F0BA872" modified="2018-07-18" version="1">MSSFLNKFTGSSNDAGNSTEGTATNSTQAQNGGGFMDKVNSVAGGGAQGEKNEDMLDKAVDFVQEKVLGQGDQSNETAAEQAKDEAISDFIRSKYKGTTGSEFPIKDKEKEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF14</accession>
    <name>A0A2T4CF14_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1467510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF14"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="55827" checksum="924326407B934397" modified="2018-07-18" version="1">MLKEPPKAWTTAQVLIYSFSIIAFFCSTMNGYDGSLINNLLQNPWFKAKYTVGNDGIWAGIVSSMYQIGGVVALPFVGPAIDGFGRRIGMLLGAILIVVGTIIQGLSNSQGQFMGGRFLLGFGVSIAAAAGPMYVVEINHPAYRGRVGAMYNTLWFSGAIISAGAARGGLNVGGDYSWRLITWLQALFSGLIIMFCMFLPESPRWLYVHHKKDAAKAVLTKYHGNGNPDSVWVQLQLSEYEQLLNMDGADKRWWDYRALFRSRAAVYRLLCNVTITVFGQWAGNAVLSYFLGSVLDTAGYTGTIAQANITLINNCQQFAWAILGAFLVDRVGRRPLLLFSFAACTVVWLGMTVASSEFAKSYAGTDANGDAIYTNPSASKAALGMIFIFGAVYSVGITPLQALYPVEVLSFEMRAKGMAFSSFATNAAGLLNQFAWPVSMDKIGWKTYIIFTLWDLIQTVVVYFFIPETKGRTLEELDEIFEAKNPVKMSTAKKAVAVDSHGDIVNIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF63</accession>
    <name>A0A2T4CF63_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1397497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF63"/>
    <dbReference type="STRING" id="983965.A0A2T4CF63"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="52599" checksum="D01CD23A8D9FA644" modified="2018-07-18" version="1">MRKQPNTDFLSGNRTQTALPLAFNFIASALGSGILFSYPELATIAGVQGVVVYALASALPLLVFAALGPMIRRKCPDGFVLTEWTRNRYGTVAMLYLSFMTLVTLFLYMVAELSAVGQVVNALTGLDGLPVIIVECAVTTIYTSLGGFRISFLTDVIQGAMVVGLIVIATITIGVKAEIDRDLIDSSGLTKASLVGWQLVYILPVAVLTNDFFLSNFWLRTFSSKTDKDLWVGVSIATVAVLCILTLVGSTGLIAAWTGAWPGDSDIDGSLAFFALLEQLPSWVVGIVLVMVVSLSVSAFDSLQSAMISSASNDLFRNRLNIWIIRVIVVLVIIPTVVIALKAPSILQIFLISDLASAATIPALCLGLFDTFYWWRGFEVVVGGLGGILTVFIYGAIYYGDAKSGGELILLEQGLYGGDWGAFGAFVAAPVGGIIWGFIALALRLSVQFTLAKMRGERFDALDRPLAETEEDDDTQLVTEISTSVPGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFN6</accession>
    <name>A0A2T4CFN6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1388649</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFN6"/>
    <dbReference type="STRING" id="983965.A0A2T4CFN6"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="112"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="646" mass="71403" checksum="AE471A32411041BE" modified="2018-07-18" version="1">MFRTGIRRCGALARVATSSTKLLSARAAFPASFSGAASVSRSVAPLKSFAQFNRLYSADAAVAEEKTPENAAVGEITAFRDLESMGVHRNLLDAITQDMRYESMTPVQAKTINPALKGTDIVAQAKTGTGKTIAFLLPLLQRMIEEDPTLATRKASRSARSDDIRGIVLSPTRELAEQIATEAKRLCRRTGLVVQSAVGGTQKSAMLRQTQRQGCHLLVATPGRLNDLLEDPNSGIDAPKLAALVLDEADRMLDVGFEKELNAIQSHLPTDKVRQTMLVSATIPDNVIQLARKMVRPHDFEFVQTIPEHDTLTHDRIPQHVVTVSSWANVFPSLFELVDREVAAAKEDPTRPPFKAIVYFNTTSMVELAGELGYQRRQSGQLRIPTFAIQSQLSQFQRTKAADMFRNSRTGILFSSDVTARGMDFPNVTHVIQVDAPRERESYIHRLGRTGRQDKGGEGWLFVPPMSANSARKLLRGLPLKPNKTLESAEVDLSAVEELPAYHEETKNLIQALPRKLMAGAYTSLFGGQLTDREQLVEDLNDWAVKGWGWPEPPAVSHSWARNQGLLNAGLNIQDGHSERMHRDDRRGDRFGDRRGDRRGGGGGRFDRRASQDPFTEMGRRARRDAPPAQRSRGGRRGGGGFESSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFQ4</accession>
    <name>A0A2T4CFQ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1124359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFQ4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="202" mass="22415" checksum="A92B7D475FE3247B" modified="2018-07-18" version="1">MEKMEVLRRHFFCRICQVLLAAARADITSPNRYSLLCAEAQTSSPGWRQADTLLLKVELSLAFSCLALSVLKCRNRDLWFSRWMTSSWAFMLVLSGACRLRKISLPAPPCGQKRGPPCLIPTSLVSKENSSTAASSMATAKRQMLRSQTCLIRLASSVARCQFGENHQQCSGPSEGWLIWEDVAKRPLNPSMLIPSLLLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFR9</accession>
    <name>A0A2T4CFR9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1428111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFR9"/>
    <dbReference type="STRING" id="983965.A0A2T4CFR9"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="226"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="337" mass="35922" checksum="BF51E94EA5B29134" modified="2018-07-18" version="1">MAMDVKAAKQQGRFGVSDGDASAGVRNAVEAFGQKSVELLLLMSRSGLWHCIGWRSGSAAYGGYSKTSYGAQGGDDSGGFFAGGGSQQGSQGGGGGGKSYQDESLRPLTIKQILEAEEPYSGADFKVDGATITQITFVGQVRSINPQQTNLTIKVDDGTGQIDVKKWIDVDKQSDAEPGFEIDSHIRVWGRLKSFSNKRHVGAHVIRPVTDFNEVNYHMLEATYVHLFYTRGAVGGANAGGDANGDSMFVDGGDGYNAGALVGQTANKLSHCSNKAKSMFMYLKKSSADGTDGVHLNKLTAELGLGLRDVMEAADELMTQGLIYTTIDEETWAVLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFW9</accession>
    <name>A0A2T4CFW9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative isomerase YbhE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFW9"/>
    <dbReference type="STRING" id="983965.A0A2T4CFW9"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754750" evidence="2">
        <location>
            <begin position="25"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="399" mass="42554" checksum="D1DF340227901C78" modified="2018-07-18" version="1">MPSRRNLQRSLVSTLLCAGNLASASLVYVSSYSQTVTTLNYTHGQNTGIQKLSPVAVSQGCSDNPSWLTLDATDSILYCINEGLNTPNGSLTAFKTTASGSLRQLGQSSTPNGPVSGVVFGNNRHGLAVAHYGGSAFTTWDVSNPSSLKHLQTKTFKLTGPPARPDRQDAPHPHEAVLDPTGKFLLVPDLGMDLIHLYSFDPNTLALKDITPLSVKPGSGPRHLTFVVKGSKTFAYLVTELGNTIIGYDVTYPNGQIKLTEIFNIPSHGAGPAEPSSYAASEVVVSPDTNYLIVSSRAENSTSIPDFDDPSRIIPSDPLINFKIDPTTGQLQLLQIVPAGGQFPRQFSINKEGNLLAVGLQNDGRVVFVDRSPETGLLGGFVAYADIEGQITAAIFDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG77</accession>
    <name>A0A2T4CG77_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1348597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG77"/>
    <dbReference type="STRING" id="983965.A0A2T4CG77"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25164" checksum="F3A2ADB3735AA22C" modified="2018-07-18" version="1">MAPKSTSEGANTTAEATKKKHGFRVGPENLPDGPWRRKVDKKKRELIHNAKLKKQYAKIKQQELKAAEPKPHPSHGNDENAEHDGEDGARSAQGDETKGDIAVEGEQIHPARQLMLKDESMAQAGAEPERTTGPSDGQRRRTRRPGYYDKQLKKAAERREEAEKRRKEWERRMEERAQKQAERERFKKAMAKTRDKDGKKKLGRESSLLLEKVKKLVGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG79</accession>
    <name>A0A2T4CG79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1129053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG79"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="172" mass="18691" checksum="A96A0093962BBFF7" modified="2018-07-18" version="1">MTTEAVVMLLPGGNGVKDGSQFATLQFANSCLVSLTCCNRRPRATPQESKAKSQGSRMQGREDRRAITEYGVDKKLKEIPEEAEARHCYSDFDLAPHPGGPLIRAQSLARQSAPPSITFDTADRTGPNALAALARHLLRAQAAGERKKKKEKGNKESGRVRRGPKTGGHIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGI2</accession>
    <name>A0A2T4CGI2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1298932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGI2"/>
    <dbReference type="STRING" id="983965.A0A2T4CGI2"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="161" mass="18857" checksum="FE249C24C0B59F4A" modified="2018-07-18" version="1" fragment="single">MDAAVDMADSEQALDLARIRFQLIRLEDTITFHLIERVQFPYNKTIYTPGAISIPDSNLSFFDWYFFQQERLQSLIRRFESPDEYPFFPEALQKPILKPLNYPKILHNNTVCVNDKIKKFYIEKFLPKVCPDFGREDRGESQENYGSTSTCDIACLQALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH46</accession>
    <name>A0A2T4CH46_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1417626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH46"/>
    <dbReference type="STRING" id="983965.A0A2T4CH46"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="405" mass="43531" checksum="25DB0226B874D8A8" modified="2018-07-18" version="1">MSFSFGFSGDDIDPDLNESQPQPHSHSHSQPASQPPSSSYSAFPVAGKPQLPATIHPLSSLLAQLPSKIAYDTLAIDLTNDVPPSSSNGNDGSSSSSSYYSPPTLALPRRELWDVRVQLMAEDDDVLSGEDRVDDGGLGKHDVKTGIYEGGFKSWESSIDLVRVLAAQDELTTAAHQASSLRVIELGCGTALPSLALFTWIMHRQSRSQWPNSPPLPCSLILADYNPSVLRLVTLPNFLLAWALHSSTHEPALADAFTIDGELELSPAILHAFETFLSSSGIHLSFVSGAWSPEFIGCLYDLPAFSAAESPAPRTLMIGAETIYSPFALQAFAQTVFAVLERERASGATAAAYVAAKRLYFGVGGSLDDFVDLARSKGATVTELREESEGVRRGVVHCVLQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH72</accession>
    <name>A0A2T4CH72_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_70754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH72"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="217" mass="23046" checksum="6B9FD3BA0DCF15B3" modified="2018-07-18" version="1">MESPEVHSRSPVRPAGCPCPGKGSGDQRKGRQSASAIQGRSHCNGGTTARANDRGDRATVQHRLHGCGSPWTSGEGLPATLKVSVDTSSGTPRYASGSRYRLCYGAGTKLRLQRYIHTLLSISQGHSAESEFVASVELSAGCLRFRPELECDLTGVLSYHSLCATYEGGRGEDLDDGPRGGPRHPSHTSGARERRGCAARRTPKSPSQQLGHPRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHD2</accession>
    <name>A0A2T4CHD2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1396105</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHD2"/>
    <dbReference type="STRING" id="983965.A0A2T4CHD2"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="998" mass="107376" checksum="95BE252C3D2FA762" modified="2018-07-18" version="1">MDNAYALPIDAVLAKFNVQERSGLTDSQVEELRKKHGRNAIPDEPPTPIWELILEQFKDQLVIILLGSAVVSFVLALFEEEGGWSAFVDPAVILTILILNAVVGVSQESSAEKAIAALQEYSANEANVVRNGGHVSRVKADELVPGDIVSVAVGDRIPADCRIVCVESNSFAVDQAILTGESESVGKDPNAVVSDEKAVLQDQVNMLFSGTTVVTGRAKAVVVLTGPNTAIGDIHESITAQISEPTPLKQKLNDFGDSLAKVITVICILVWLINIPNFNDPSHGSWAKGAIYYLKIAVSLGVAAIPEGLAVVITTCLALGTRKMAAKNAVVRSLPSVETLGSCSVICSDKTGTLTTNQMSVSKVVYLNDAGSDLTELTVEGTTYAPKGNILLNGQVVENLAATSSTIRQMAEVAALCNDAKLAYDSRTATFSSVGESTEGALRVLVEKIGPCAPAGTALEDCGHFASAEHEKRLPRLATYEFSRDRKSMSVAVQDGSAKKLLVKGAPESVIDRCTSTVIGANGNRVPLTEELRALLLKEVVEYGNQGLRVIALASIDDVSQHPLIGSAKTTEQYAQLEQNMTFLGLVGMLDPPRPEVPASIQKCKDAGIRIIVITGDNRNTAESICKQIGVFGQHEDLEGKSYTGREFDNLSPSEQLEAAKRASLFSRVEPGHKSKLVDLLQSLGEVVAMTGDGVNDAPALKKADIGVAMGSGTDVSKLAADMVLADSNFATIEVAIEEGRSIYNNTQQFIRYLISSNIGEVVSIFLTAALGMPEALIPVQLLWVNLVTDGLPATALSFNPPDHGIMKRQPRRRDEPLIGGWLFLRYLIIGTYVGLATVAGYAWWFMYNPEGPQISFRQLSGFHRCSTEFPEIGCEMFSNDMAKSASTVSLSILVVIEMFNAMNALSSSESLLTLPLWNNMMLVYAIALSMALHFVLLYTPILQSLFGILPLNALEWKAVTIISLPVILIDEVLKVIERQFFMQQKPAAKAIKAKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHF0</accession>
    <name>A0A2T4CHF0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1322958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHF0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHF0"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="257"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="696"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="944" mass="104093" checksum="24156439841B1435" modified="2018-07-18" version="1">MPGLARKILVFAAVDGLVIQPLASKGQKPFQSARIKYGDASVSAARDQAPDSTKPDSWFEALGVIGLITVSRLTYLVTITRREQVAQVFGLPIYVVTQVAVTPCSSQAEAEESVRKTARLLRSEPSSSANHDDESSSDEDGDMPTATTDEEVDDEVVDKGGVPADPKSSVVQDVIRRRGSYGRFAQRWFSRSGWTADQRRTMGMSNSPTSTPPLAQSAPQASAAGLSSLQEAEGNPVIPPSALLPKLLRTIQVLFGSSHSFYFSYDLDITRSPTDDASVAKPSSLLHTQVKRTFFWNRHILQPFTDAGQDALALPLMQGFVGQRTFVVDSQPPQADDPGMDSMELANLSPSSSVPSSPPPGTVKRSLELRPTEKSYLITLISRRSTKRAGLRYLRRGIDEDGYTANFVETEQVLSSPTWEASSPIYSFTQIRGSIPLFFTQTAYSLKPVPVLQHSEEANYNAAKRHFERLSASYGTLQIVNLVEKRGVEAPIGTQYQNTVARINEGLDDKAKIPFEWFDFHHACRGMKFENVSQLLSTLKDQLEGLGSTVKSNGQLVRKQQGVLRTNCMDCLDRTNVCQSSFAKHMLELQLKEDGIDMSAQIDQETAWFNTLWADNGDAVSKQYASTAAMKGDYTRTRKRDYRGALNDLGISLTRLYSGMVNDYFSQAAIDFLLGNVTAKVFEEFEMDMMTKDPAVSVEKMRERAVELCQKRVVADVSEEFHGGWVLITPNAANVLKSWPMEEAVLLLTDAALYLCRFDWDLDKVSSFERVTLASITNIKIGTYITSTISPAHMDESRNVGFVVSYQPGTSDIRRRNTRSLSTKEAPKLTASDEPQSAQGSGFAGLFGGNASKEPAIRKLAFKAPYADSSMSVSEAGPGQTELQKVDTICSEIERLAFERQLVKEGEERKKLVERGDIISLDAAKRNTGLLEQLGHSLKKLVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI63</accession>
    <name>A0A2T4CI63_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1010931</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CI63"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="3681"/>
            <end position="4017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="285"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="910"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1512"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1570"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1942"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2020"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2309"/>
            <end position="2503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2628"/>
            <end position="2647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2797"/>
            <end position="2875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2976"/>
            <end position="2999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3054"/>
            <end position="3092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3167"/>
            <end position="3205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3306"/>
            <end position="3385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1182"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1528"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1954"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1970"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2020"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2035"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2054"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2350"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2417"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2797"/>
            <end position="2842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2843"/>
            <end position="2857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2976"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="3184"/>
            <end position="3205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="3348"/>
            <end position="3362"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB81243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="4017" mass="446761" checksum="F892FB476C86CFB7" modified="2018-07-18" version="1">MGKITKTMQPKHRETLSSWLKQYVESASTAPLPLLPQLLADFPTRWPFGRGDLYHWIPLLNRFDSVLEHFCKVYKLNEGPQQRDFGCDVLLNHAKDSAFEGEKQWQPDELTQLGFPSDGDRVLIEAVLKFTRMLLEHCGNRSIYASSAHLNDLLNCIPPSILIATLEVGSELAQRYQASVKRIGSASRHISAALLANHYNIDLDRVQQIALPFVKTPIFNISESAPTGTHASTSKGKDKAGAGVGGRNVATMHANDLVAIAASDDSRWSTWGDVKVAYYPQENIPSQQDASAETGRSNLPSSPTPLRRSSTMNPQHTPRVRNVASDDSSPLVPRTSASADDHSSSGQKTFELPQSVVASRPIYELVKRIPDDMPPATKYEAFHRLRVAKALIDSQESRQQILATRLLAVTNLAYIHSESNFVEKVLRQDIDETRRFQLVYQLAELIHPSADGTIEIPLRLQTIALALLEAVSSFHARCQDVLSALNANVNHGILLYVIRKAVAGMTETNAGDDGDKANEIDEWRNNLFSLTLHLSMATRVGSEMVSAGLMDILVEILNIRSVIAQRHHSMVLAFLDGLVWTYPNAFTAFFNANGLDAVAKLIVDTIGEARSLLRASKGIKPEQQSSAVDYEIPYYQQQTLKWILKFVHHIMSNSYSYSGNTDRLLRNLAEKSDLLANLRDIINDKKSFGSVVWTNSVTILSDFINNDPTSFAAISESGMIRTYLEAITGRPIPDDYTTRPRYRESEGDEPGTVDVSAVTSITDLDSRPHPPSEDSIKQSLGRPVATGILASSDAINVVPQVLNSISLNNAGMQLVVASRAFESFLEVFESPAHVKCMEVDSELASNVGASFDELARHHPPLRKSISNAVIDMVARVRMLGIEKARVAGWGVKLLPIGSLLAAAGPTAVAEASKPPQQADMDMSDTAAAPQASEADKRTEAERDSPYESFTPYIYALSNFLTTYLSNGVLKNNFVERGGIELLLDMCQSPSLTAGYGDSLASRVLNQVISQLVEHAPAQGLTSLLNRAQRAIDVLEPLSTKTEAVPPYFAPFLADLGIEYSSSEAAEILATGTNIVKALLNAQTYMKIISDCFVSSRGNALQFYPVNVYDYYIKLVKSIGPLLRGVLAEEAGELTAIPQHWSLRRHSPPTVGGSRGSGADAEADDGSLTDVLGGADSWRPSDGTDTSSTSRLTEQEQASPRFQNYETLRVLLHPMIPTSFPLFQTIGKALLPRRESNHGDPYHRPRHLQIARALADTVLDHLRPSVATPEPTSKDFHYWIIMLHTIHEMVIEHPASSRPTDRANVQIIMPVLLAFKERNGIVVLNDMLRVFADAVKSSSAATADDSSKVKVAAFGLKKILDLYFILVNGKHIGDTHTYYNLQRQTDRSQFVQNIHSQITVEFRALILPVIMDLWDSAFVERVPDQTVKRLVDILKIVALGEGELQSMPKDKIPFVLLKYTEVRFNWRSVRSLVRQLTDDFDESLAQEAAYRTFGNPNTASAYCSAHEAEIAGARNPVPPEDAPDASSLAEGTTPTSASRDASGSRAPDPEAMSLDISPDASAENLDDLISQLPEGNDTANESGADTAAKAAEPTPASGEAGSTPEYTADSFNALKQGLDDQRSKLRENLIDQCLDVIRAHPDTAIEVSELITTVVLRHQNADAHEEVGSTLTSALTSLALDEDERKRNGKCIAAYAHLLALLLQDEMFFSRNMDTLREKIDEYVALLKVPPSTPSEELPPWIPFILLVLETLLSHDEKPVAVQWRAPKSLDEPAAEPVIQLRTPLLDDQQRSDVLESLLDLLPRIGKEEMLATAILRVLIILTRRRSLAKQVGEKKNLQRLFLMAKQMSGSGSERLRQIRLTAHLITILRHIVEDEDVIKQVMRAEIKSDIPNLQRTQRGHLDVPTYLRAMAPIALRAPDLFVEVTNELLRFSRWNAPTAEGARPQTLVWKEQESSTTDVAQPDSENIQSEDVKQSTEPGDKEMPDALKPHHDSKRPVVENPDGVIHFLLCELLNYREVEDKEVPPPSRDAKTETESAASADAQDSASAEGAAADGKDKKPLKPTFKSEEHPIFVYRCFLLSCLAELLQSYTRTKMEFINFKRSAPPLSATTPVKPRSSILNYLIYDLLCQSSLSGTSDNIAAKKKAATSAQTQKVLVALVSKTNEKVFDRKQEKYAYDDEPDLLFVRKFVLDTILKAYEKAPLTDEPLEVRYARMQCLAELMNNMIGEKDKEQASGSRNVDSVQTRSQAQLRRLMYEKGYLDKLTSSIAEINLNFPGVKRAIKYILRVLRVLTDTAKELSHSNILVADSQAEQSDEEFASTSSLSDLDEGREETPDLYRNSALGMLEPRGEDDESESEEADDDDEDMYGDEYDDDEMDYGDEEISDDEDDISDDDEELSQMGEIEGLHGDPGVVEVIMDDEDDDDDDEDDEDDDEVDSADMEDLEDRVEIVDEDGNPVEDDGESGWESETSAEEDDEPEVDDIDYEGEGQDEDEAHLHGMGPGDLLDNMARAIMGGDEDGYEPELMEALDEHYMDDGHDDGDEDDEEDMEDEEYIYDDDYPLNDPLPPMPALGWDGFTPEVDDRHRQVFLLDNNRRPVLAQMNNRNPFPPRFIPGSNRDLSDFRSYFSRSHRNNGQQPNADDGMNPLLRRSDQAQENQPRPGHPHSIGLRFPEGFLGPGRHLMEGPMGFLGELMEFLPIMGRGNPHAFHVHISGPGGTRSTELGPIRGLRSEQRRDAASQEPHQAVAFTPETTLDRYQEEARMIFGNPVAEAARLGNTIIAQLTPAAMELERKLKAEEEENQKRLEEARKKREEEERVAREAKEAEEKAERERKEAEEREAAARLAAEAAEAAALAASQNAEAQPGDGQGSGAMEGVESTEAGVAAMNDDQASTSRANVPRVTTVIRGEEVDVTELGIDPDYLAALPEEFREEVIAQTVSERRSQAREEAASGEATEVFQEFLDALPEELRMEIAQQERQDQRRRHREDSRRQVTAADGQDIIPAEMDPASILLTFPPELREQALIDQGEDIMGQLPPDMAAQVRALTQHRPPVAHQRGGMRPIVLPGRSSLGPARVTVQGSPDEQGENKTPRKTVVQMLDKAGVATLLRLMFIAQQGSIRNYLFSVFADVCENRQTRLEVISTVLQILQDGSTDMNAVERSFGQLSLKARKQKDKEKDGDQKNPQSLKRTLTTVGSLTTPGQTNSETSPLLIVQQCLDLLVDLCTKNPHIPWLFLTEHESIGSSSLKRSLSRRGKGKDSKAHKYAINSLLTLLDRELVTESSLVMTHLADLLNRVTLPLQNLERRRKEAQDEDAAGSKGTGVETQGPPTDANETERRDDDDQTVDGASASAQATSSEQKAAGTEESGEQPKSAPQKRARQLQPPVIPPQNLTLVVRVFVARECSSKTFQNTISTIKNLSAIPGAKTIFGQELVSQARLLSSNIVSDLDDLLPHIEAATSGTEIQGVALAKFSPGASEQNKLLRVLTALDHLFDGKKKGDDADDGSSEKNEKQDLVTSLYHNSTFATMWEKLSACLSAIRQRENMLNVATILLPLIESLMVVCKNTTTNDDLSSSMVGKDMLSSPQPESRTANLFFTFTEEHRRILNELVRHNPKLMSGTFSLLVKNPKVLEFDNKRNYFNRSVHSRTGQNQSRPSYPPLQISVRREHVFHDSFKWLCFKSADEMKYGKLNIRFNGEEGVDAGGVTREWFQVLARQMFDPNYALFIPVSSDRTTFHPNKLSGVNDEHLRFFKFIGRIIGKALYEGRLLDCFFSRAVYKRILGKSVSVKDMESFDPDYYKSLCWMLENDITDIITETFSVEDDEFGVTKIVDLIPNGREIAVTEENKHEYVRVVVEHKLLSSVKDQMENFLSGFHDIIPAELISIFDEQELELLISGLPDIDIDDWKANTEYQNYSPSSPQIQWFWRAVRSFDKEELAKLLQFVTGTSKVPLNGFKELEGMNGINRFNIHRDYGNKDRLPTSHTCFNQLDLPEYDSYDILRSQILKAITQGSDYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI87</accession>
    <name>A0A2T4CI87_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rgp1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_44943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI87"/>
    <dbReference type="STRING" id="983965.A0A2T4CI87"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="827" mass="89361" checksum="375F27F583F41A78" modified="2018-07-18" version="1">MADGFSNIRVFVHWRDQTVFAGEAVQCTVTFRNIAPEANQQQQQQQQLLQPFSPHPHGHSNSHSQTQIPSERQRLASPIQTRGKVAASARGHRRAALSLSVPSPSARSRQGSLQWPQPAASGDSRGHAHKRSISIVSIGSTTSTIDEHSQSPRFDNSPRAQRHSHNRASSLQIASRGPPAIPSTPQSGSFSQRPSSSPFNASYPPDRFGRIPVPRSPQSSTLSVQRRSSRALASPMPDFRFPAAPAPESETISSPRKASGNSMLSPRTGPVDSNLPIRSKEQLPPVPDRPILTARILSSTSMAGGTPRSSGEFYSISNNSSETLASEYVAPPLTRGSGRPSYPRRGSGFSVHQSRTESLMMGFAQIQGSFSLDGSLISLAPFEQVKKKAVVGGRGGGVVGLESGRRENGLLRGFGWGSISNSLGDFLGGGELSTIKEMRGVANSKAVPLLSTPQSILFVDLQLAPGESRSFEYTFKLPKGLPPTHKGKAIKISYSLVIGTQRPGGAREQHVRTVEVPFRVLGSVNSHGEILGHDLMNPYILLRDEALVKMVGKQQKSHRERDAPGGSAAMSDFLSYVDSLTNRPGDKAGESLLSPTATPDLRRLSSSSFEETTSNKEAIRLAIMKSNQTSQGQQSASRFEIARNGQRVGVVMLTRPAYRLGEVVTMVIDFADADIPCYAVHATLESSERIDSSLALRSESSVHRVTRKVYAASSESTLFTRRVVFTPTIPISATPEFVTSAISFEWKIRVEFVVPSQGHDASKGQQTPYPLLEQISRDDKGGLVLVAVENLSCESFDVPVPLRVYGAVGTGLERLERDEASEEGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIM6</accession>
    <name>A0A2T4CIM6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1323319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIM6"/>
    <dbReference type="STRING" id="983965.A0A2T4CIM6"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000064">
        <property type="entry name" value="Probable acid phosphatase Pho610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF15">
        <property type="entry name" value="ACID PHOSPHATASE PHOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015586821" evidence="2">
        <location>
            <begin position="18"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="430" mass="47643" checksum="F8DBF235C3662E37" modified="2018-07-18" version="1">MLSKVVSLLAAAGLASAAAVDKSQCKPSSTSTGWETRYTATGTAEVAAAAATAKTSSPTSHVKGKAFDRFVVVYFENQNYDKADGDPNFTFFAKKGIKLTNYFGVTHPSEPNYMASIVGDYLGMQNDDFNAADFNVSTVIDLLEDRGISWGHYQEDMPYSGFEGFQYTNVKTGANDYVRKHNPAILANSVAHYEQRLSQDKNLSLIDTSRSMFHKDLEANKLPQWMFITPNMTSDGHDTNVGVAGKWCRAFLEPLLDNKNFMQNTLVLLTWDENETYAERNQIMGILLGDAVPKHLVGTTDNNFYNHYSEIATVEANWGLHTLGRWDVGANVYELVAQKTGDRLRKWSSDKALNSHFWNASYAGVFNTDGGNQQYPAPNLKLDHSFSGRTILPAIKKTWEHSKAATYYADTIEVADGLNPPKGYAPVLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ28</accession>
    <name>A0A2T4CJ28_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type ATPase, C subunit family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_15944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ28"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ28"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="54424" checksum="D835C81D3C68D01F" modified="2018-07-18" version="1">MLTRISSQAVRSLFPRRGSSALIRSYSSSSRHSQTRFTYAIPENRQINYDELFEKLKGRKILDNANGHNAAVLLTTPNFAKDLENAHLMKEFARLMAGSEGVGKFHVLSAVVDHLAAPIGSLRPLQGLSVLRGHLDDMLPYLWHEQPPKSRDDADSVSALTFSLGDPALTLPLARTTFHNNKASTLLLSEFDLGPDTAQLARQLEKHSQFVKVSLDEEIKSLAHLDMWAPLLPLTHPRAVTESFGNIIRGIEVDGKTIPASTELEDIVNALHKQNAQSGILSGPVGVWAMVTPNPETSSTLAEWIEEAPEPIAALPDVDDIRDTVSATAQHLKQLYSHGGRLYKILSGGGGWGAKKGLLSLDPQRTHFSLSEEEEMNNFMQSMNGEGFTPQGSQIQFFMSAPVLPNVTEPFTPGVAFGVAGDIAVPREPEPVEGFIGQHFGALSNAAVYLSGEGLPGGKETKLSVPHSRIYGREPGAKMGILENLAYELAEAGTIALAGLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJH1</accession>
    <name>A0A2T4CJH1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1323576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJH1"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="46"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="37138" checksum="15CDE1656AA53BE1" modified="2018-07-18" version="1">MSRNEEGERIQQIANSLPPIPVHGFTKTIQAITYTVCILATLTVALRIYVRMRLSGSERAWGWDDIFAVAGWVPLLPSVVFLILATYYGLGARDDHVPEGMLIYYQVRVKGYMFIFEMVYFASSVLTKLAMAIMILRLTSTRHYAYIIWGNMALLGVNATVCLIIMFVSCSPLPALWNEKLGYCRIEYGWIIISYAGSVVLAIVDWTCAITPFFMLRSLQMPKRRKISVQIILGLGIFGSAAGLVRLGYYHAYDTVKYPHQSLYNWGSTILWSVLEAGLGIISCSLPPLRRLFRKFYQGSSGQSGMRSGPATVDVRTTPYRDKMSKLNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJN5</accession>
    <name>A0A2T4CJN5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJN5"/>
    <dbReference type="STRING" id="983965.A0A2T4CJN5"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="660" mass="73006" checksum="7FE7A4913E0DEDD5" modified="2018-07-18" version="1">MDPLAIAKIAFQVTCVAVKTFRNGLNFTKDAERLVLGLEVERFRLHVWGENAGLAPSGGQPATLPSRLLPICEIIKDYLEQIEQLVRDADGLSSGYGLLQTEEPPTKSELVRGLVDRMQRSIHKSGVKLGSGGEDDKDGGQGNEDEADAALGLKDLSLQGKTTTTKWKKIRWAVRDLDGFDNLIKDLAHRVNKLNDLLTETQQRKTREDNYRVNMVVVGSAVDKASLELIRAAMRGESDTLQVRTAIERKALFVTEAEHGSIGFAGSSTSSKHLPSVRTMAPPPLSLDDFVLPTGFAEMKRFVTVKRSSAAQGPYYLLERKTFDANILPQDMARLTSRVQRLVLLLQKPKSPEFQTPHAEGCIKDTTRFCWWIVFRFPLHTMPQREVSRRLPSKNKWAPVSLVSLLELAKFRPPLEQRLALASALCTTFSELYLSGWLHKGVRSENILFPTAGAILQLPPYAYKPEEMRVILSSPLVCGFDYSRHESEWATIDKARMSDDVGVTIYRHPNYQGEAAEGYKVQYDIYSVGLILVEIALWKPLISFLEAKKSSSSSSSPAPSSSAVQMGVPSKPTSVSLSADMASFHTPHALELKKRVVGRVDSELAFRVGSPFCQAVKFCLKFADEQPDTGAGDGGEVGVHPAMEFYNNVVVPLAAFSTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP19</accession>
    <name>A0A2T4BP19_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1434783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="KZ679160">
        <property type="protein sequence ID" value="PTB71065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BP19"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="261"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB71065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1465" mass="163782" checksum="76CE92308F761FE5" modified="2018-07-18" version="1">MAHAAFVGSTKEQLVDNLPKRFKGIKFGIQSNQDIVNQGVLEVSQRMLYDIDNNRAPLTNGALDIRMGTSSKSGKCGTCQEPLKFCIGHFGHVRLALPAFHIGYLRFIQTILQNVCKTCAKVLLTEEERRSFLQDLRRPGLDNIRRTQICKRINEQCRKCRQCPYCGEINGQIRKVGVLKLTHDKFSAYKKSTSQKKLPPESKLAFDASFDEAKKLNPDLDKHLVRAMEDLNPLWVLNHFKMITPTDCELLGLDPTEGRPEMFIWQFVPAPPVCIRPSVAQEGASTEDDLTAKLAEIVYISGLIRTALNKGKPMQTIMEQWEYLQLQIAMYVNSDVPGLNQPGFGKSIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLGINQVAVPQLVAKNLTFPERVQSHNMEKLRQCILNGPKVWPGANHVIKDNGNWKQDLQFGDRALVARDLRIGDVVERHLEDGDVVLFNRQPSLHKLSIMSHLAKIRPWRTFRLNECVCGPYNADFDGDEMNLHVPQSEEARAEAITLMGVKNNLATPKNGEPIIAATQDFITASYLLSSKDRFYNRKAFTYICTHMVDGVTHIDLPPPSIIKPEALWTGKQIFNVLMRPNKQSPVLVNLDARCREYSARPGQCPDMDPNDAWLVIRNSEVMCGRMDKSIIGSGKKNSVFYIILRDFGPDHAVYAMNRLTKLCARQLGNQGFSLGVGDVFPSTELTKSRDKLVQDAYDKSDALIETFKQGKLEKAAGCDMEQTLEISISGILSKVRQQAGQQCVDALSRNNAPLIMANSGSKGLHINVAQMVACVGQQIIGGQRVPDGFQDRSLPHFHKNARQPASKGFVRNSFYSGLFPTEFFFHAISGREGLIDTAVKTAETGYMSRRLMKSLEDLSTQYDNTVRTSSGTIVQFQFGADKLDPVDMEGSAVPVAFDRTWTHAESTTWDNNERSLLPHEVLEVCSSMLDKEKLRYKRRRLVDNALLDYSDPTDEALDEHESARGFIDTIYSYVADRAQKMSKARALVGLDPDPRQDEDLANASADLKARLARVERVSKISLTTLQRFVKECLERYHKAHVEPGHAVGAVGAQSIGEPGTQMTLKTFHFAGVAGMSITQGVPRIKEIINASKNISTPVITCPLLNDKQIEAARIVKGRIEKTFVIDVLKAIEDEWVSDRGTIVLYIDMEALQNMHLGIGVVDIAEAILRFKKLKIQPTDVSVGPNYIKIYVLNSWVDPDAAKKRQRGTASLTLTEEASDFLLRVNHLRRMLPKVPISGYNEATRAIIQTSEQNEHTVLVEGYGLRACMTTEGVIGTKSRSNSVMEARDVLGIEAARTTIVDEISSVMAGMDIDPRHIQLLADVMTFKGEVLGITRFGLSKMRESVLQLASFEKTPDHLFEAAAGMKTDRIEGVSECIIMGQTMSVGTGSFQVVRRLNIQEWEVKPKKTLFEDAWAETVKAKKERRKLRGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP50</accession>
    <name>A0A2T4BP50_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1345056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP50"/>
    <dbReference type="STRING" id="983965.A0A2T4BP50"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="145" mass="15756" checksum="1DE04B24DFF1FA05" modified="2018-07-18" version="1">MAGGKPRGLNAARKLRTNRKDQRWADLAYKKRALGTAFKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP66</accession>
    <name>A0A2T4BP66_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1473761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP66"/>
    <dbReference type="STRING" id="983965.A0A2T4BP66"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="145"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="585" mass="64392" checksum="46A29DF662B0DA6B" modified="2018-07-18" version="1">MQKIKSKLPSWDSTKTTSKKGFDKVWGWADKLGAPVNRLSNRIGSEAFWPTTLDKESDKAARILRSFCKDGFYTEEERPADDAGPKRKQRVVKKIPQKVIENAVGLAIFTTMRTGLWVSGSGGSGVLVARQEDGSWSPPSGILLHTAGLGFLVGVDIYDCVLVINNPKALEAFTHIRATLGGEISAVAGPVGMGGVLENDGKWKQANRPVFTYLKSRGFYAGVQFDGTVIIERTDENARFYGEKIGVADILAGKTKRRPPELKMLMETLKAAEGRTDVDEELMDELEGQPAPGDVNVEAPSDGKLFGIPEPDDPDPYGVLALQREGLDIVEAGTHTRPSSSQFEYHPSPSSPVYAKFHSRHSMDTSETRSNRDSYTSSRLRWSSDRHYESSDAGTQTDEVITPGTSPVFNNFHQRNLYDESNEFYNGVNDSPWSSKGRKPSIHRDWGRDDSLTFFSEDDEKSEGAFLSPSDLRSQSISAPPVDAVITPARIPPPLPPRNISRPLKTEFEEVDLKGAETEGSTNDSMSDATSLSPKETPASKEFDLPVLRKESTNTLFDSEHSTEDNARDEVDGFQTLPGSFSRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP73</accession>
    <name>A0A2T4BP73_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1434750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP73"/>
    <dbReference type="STRING" id="983965.A0A2T4BP73"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015668786" evidence="1">
        <location>
            <begin position="20"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="414"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="764" mass="79759" checksum="41B2F4B6E4D75771" modified="2018-07-18" version="1">MKSFSLLGSLSLLTSLSWALPTEGVTSKLEGRQSGSSWFLPNIDHTTGAVRGYVPNLFNSAGQQNFTYPVYKTVASGDSAGFVNALYSDGPSGGQRDNCYLAGEPRVIYLPPGTYTVSSTIFFDTDTVIIGDAANPPTIKAAAGFNGNYLIVGGQGDGSDHPCGGSGGETHFSVMIKNVILDTTANAGSSGFTALSWAVAQNCALVNVKINMPQGVHTGMLVSGGSTISISDVSFNFGNIGLHWNGHQQGQIKGMTFTDCTNGIFIDSGFTISIFAPTCNTVGRCIVLNSGNAWVAVIDGKSINSGDFFTSNVGFPNFMLENISKDTTNSNMVVVGGNVKVGGSTSLGTYVYGNTRGANPVYQTNPTSQPVNRPAALAPGGRYPVISAPQYADKTVANVVNLKDPNQNGGHTLQGDGFTDDTAALQGALNTAASQGKIAYLPFGIYIVKSTITIPPGTELYGEAWSTISGSGSAFSSETNPTPVVQIGATPGQKGVAHVQDIRFTVNEALPGAILLRINMAGNNPGDVAVFNSLNTIGGTRDTSISCNSESNCRAAYLGLHLAAGSSAYIDNFWSWVADHATDQSGKGTRTAVKGGVLVEATAGTWLTGLGSEHNWLYQLSFHNAANVFISLFQSETNYNQGNNGAPLPGTPFDATSIDPNFSWCSGGDTVCRMGLAQYYTGSNSNIFHYAAGSWNFIGLTKVNQGLMNFIQSTISNAHLYGFTSGPNTGETMRLPNGVEFGNGGNDGYGGSWGTLIANIASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQG6</accession>
    <name>A0A2T4BQG6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1344163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQG6"/>
    <dbReference type="STRING" id="983965.A0A2T4BQG6"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="11">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="12">
        <location>
            <begin position="198"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="675" mass="75092" checksum="0C37AD630E1B73EC" modified="2018-07-18" version="1">MAFLTATSQHNGLPSTLSNASIAKGSDLMVMKVASILSTSYSDNDFRDAILLADQRAAGSNVKKRRQLRLDLLGEAIGCNGEIVEEMGLVAERLKLVRGVVERLNSRIQDMKLQIDSAHDRTTPALRGMASLFEQRMAIERKQEVLGAIESFFIMTDDEIESLTSTARPVDGLFFSNLHKAKRITLGCDILLGFESQILGLELIDRTSVHVNMAFQKLYKWVQQEFKTLNLENPHVNPFMRQALRVLAERPSLFQNCLDLFAASRERYLSESFHCALTGITPKGTEDASIRPIDLTAHDPLRYVGDMFAWVHSATVGEREALETLFAVGKDDTLYASTSSPNATLRDLPVDEASEGSEYKVLEALGQLMDRNFLPVVRILRQRVEQAIQSNEDVIPAYKVSTLLSFYRTTFEKLLGPGSGLEECTGALEKVAKRQFRSLVRDNVLSVQGEFQQVPSNLEPPRFLQDAFKRLGAIIQIYESSLSASADSGSEIQEILSQAFDPFMTGCEEIARPMTNPEEGIFLVNCKLAAAHCLGSFESTTFRATQIRDEIAKDVLNLIDDQHAVFRKKSGLDALLRILDDAEEVDVSQASVSQASQELDDFLPSALMDAMDRLKGLQDAEMAREIIEQAAEKFCTDFERLEEFLANQKHDEDASNPDGGLNLSRTSAEIRVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQM6</accession>
    <name>A0A2T4BQM6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Phosphoribosylamine--glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1343907</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQM6"/>
    <dbReference type="STRING" id="983965.A0A2T4BQM6"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="113"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB71594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="658" mass="69572" checksum="093B2ADE01A1A8AE" modified="2018-07-18" version="1">MADLRILLIGNGGREHALAWKLSQSPRVEAIFAVPGNGGTATCPKVTNVSSVSADDFPALVQFAQSNGVNLAVPGPEAPLVDGVEGFFRKAGIPCFGPSKEAARLEGSKTYSKDFMKKYNIPTAAYENFSDYNKAVAYVDSVNHDVVIKATGLAAGKGVIIPQTKQEAKDALKEIMVDKAFGDAGDEVVIEEFLQGDELSVLTFCDGYSIRSLPLAQDHKRIFDGDQGPNTGGMGCYAPTNITTPELVQQIDRDILEPTISGMRKEKQPFRGVLFTGLMITPNGPKVLEYNVRFGDPETQTVLPLLSADTDLAEIMLACTGGYLDNCHLSVEKKFSATVVLAAGGYPGSYAKGTPMTVQTPPAGSTIFHAGTKLEGGQLKTSGGRVIAINSVGESLRAAVDASYAALASNVIDFEGKFYRKDIAHRAFRDAGKVSMTYAQAGVDIQAGNDFVEKIKKAVASTKRAGASAEIGGFGGEVDLSQCGYPNAPILVGAIDGVGTKLMIAQAMKKHDTVGIDLVAMNVNDLVVQGATPLKIYVKSLLPVLGNIKGLAHITGGGLLENVPRMLPDSLAAEIAYGTWEMPPVFQWLKAAGNVAPAEMCRTFNAGIGMVVAVEASQVESVASALRSADERVYTIGKLVRRQAGQPGCVVENLESWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQY8</accession>
    <name>A0A2T4BQY8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alanine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQY8"/>
    <dbReference type="STRING" id="983965.A0A2T4BQY8"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="311" mass="34565" checksum="93B26CE56BB96BF7" modified="2018-07-18" version="1">MSSMVSLFAAYRKRQAALETSDNPYASGVAWILGELSPLAEARIPILDQGFLHDDLCYDVPSAGDGKFFRLDDHITRFESSCAKMRFKLPLPRDELKVILFDMVAKSGMRDAYVELIVMRGLKGVRGSKPEEIVNNLYVILLPYVWLMDPEMQYRGGSAIVARNVRRTPPGAMDPTIKNLQWGDMVRGMYEAQDRGASYPILTDGDSLLTEGAGYNIVLVKDGVIYTPDRGVLQGITRRTVMEVARARVIDVRVEAVPVEMATAGGVLPITELDGQPIKDGQVGAITKTIWDGYWALHEEDAYTTTVDYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQZ5</accession>
    <name>A0A2T4BQZ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1343691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQZ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BQZ5"/>
    <dbReference type="OrthoDB" id="3852249at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046486">
        <property type="entry name" value="DUF6579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20219">
        <property type="entry name" value="DUF6579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="397" mass="45049" checksum="16BFE65F9DF411E0" modified="2018-07-18" version="1">MGEDLLSIVFKDKSYKGRAIRAAAKLFTNAAPIVKTIEAGNGIIKIGETLSKANELAGRVNDFAPRANQMADGLNRFIPAMQVMGQSVCDSARIFAYFSMIATTVRIGVNIVQTYQGVQALQLIAAKLQDISVSLAAQTALIAQKEFPDYVHSMIRERLTQTSDDASVNHWFFLWHPDDDWYPRFFHLLEEKPLGTRFCGYTNQIDSVFVFMIAARRRLNEMEYKARRRGHPLRPTRLHLLVPAYQPILIAEALKIPEEIGDFVMEGRINSNREFVWLNLPEDQRHYTLNIGQWVPPTQGWLTWAASKIGLGEKAPKLRTPRALGYSQIPFEVEAQPLPAHEDDDGSSTLVNPSIAPSEVSLLEDSDRTKDKDKDKSRRQATPLHQRERRHRSSRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRF5</accession>
    <name>A0A2T4BRF5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gpi16 subunit, GPI transamidase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1442375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRF5"/>
    <dbReference type="STRING" id="983965.A0A2T4BRF5"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015555949" evidence="2">
        <location>
            <begin position="20"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="608" mass="67284" checksum="CC1B6AF6867D9DEB" modified="2018-07-18" version="1">MRSLLSLLLLLVPSVLVSAADYHEQLNLRPLPLSALLASFNFRANTSLADFEAHNFRLFPRSLGQILQYAGTRELHLRFTLGRWDAESWGTRPWDGTREGGTGVELWAWLDAETDEEADEKWLTLTNALSGLFCASLNFIDGTRTIRPVLSFQPEGDHPNSTLQSTRLLHGVLPHEVVCTENLTPFLKMLPCKGKAGIASLLDGHKLFDASFQSMAIDVRPICPSEGECVLQLEQTVDMVLDVDRSKRPHDNPIPRPPPGHDLICDTTKPYHQPDDSCYPVDHLRGQDWTLSQIFGRTMKGTCPLTDAEVPPVCVHIPPTRDIFASEGAHEIRYSDNNSMRCYQIDQEREFTLILTNAEPTANGEAAPLGIVKPETPVLYAERSFTGHGQEHGGVQAILTNPGDDAVEFVYMESLPWFMRVYLHTLSARISASSPNVNTSSADIIKEIYYRPALDRARGTQLELLVSIPPHCTVFLTYDFEKSILRYTEYPPDANRGFDVAAAVITTLEPKVMNIRTTSLLLYLPTPDFSMPYNVIIFTSTTIALAFGGLYNILVRRMVGANEAPRAAFKDKVMGFVAKLRKKRTAVAAAAASSGGTAEPGAANTEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRH0</accession>
    <name>A0A2T4BRH0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1473259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRH0"/>
    <dbReference type="STRING" id="983965.A0A2T4BRH0"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="194"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="678" mass="74927" checksum="9A7D1973363AFF73" modified="2018-07-18" version="1">MSLSGLKPAPETRPCSSCHHPPRANGGPTAAITSLDALSQGAESGCLSCAVLGAGIQSIIGNASAQNVQPSDSAERLRMDINIAASGQSLSLTLFNRQLEISVFAQPPHKIPEFERLFPNVPIGVVDLPRSTDSDASINWVVEKLSQCDKSHACHRKSSSLTGSLPGRILDIGSADDDLIRLKAFNADSEMPKYACLSHCWGTSRPLSTTIANLEIHKQELSWNVLPRLFQDTITVVRRLGISLLWIDSLCIIQDDKDDWRREAAKMGSVYQNAYIVISASKVADSEETLFGGVDEQLKPSVISVPSLGQGSALCFRKSFTHSPGYMDQRLVRSSSLPTFNRGWIFQERLLSSRIVHFGPEELSWECRHTSACQCSPSASVDSGGGAADAYTPSAQRIFMPKAILNHGYWQKLTEAQLIQVWHMMVENYTKLHLTFESDIFPAISGIAKEFQRSSHSDYVAGLWAKYLLYDLSWHKETMSDGSAKQDEWSRRPQAWRAPTWSWAAVLGPVKFLDVGMGLNSLCEVVEVKCFPYQTDPTGELCGGNLSLRGHSISTSINYKTQVGHRSRKPFELFELDIMQGQVGNVWADYDSSLPATDHVPAGSVVQCFILATRIDSGSLTMLLLRQSGYDEDNGGDFWKRLGLVQLSKPPHVALEAKDYWLNVFKERLSDMKIVKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS86</accession>
    <name>A0A2T4BS86_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding methylated-DNA--cysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1364376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS86"/>
    <dbReference type="STRING" id="983965.A0A2T4BS86"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="14209" checksum="8EECAA0AE73359F2" modified="2018-07-18" version="1">MARSDEAQAFFHAVYSATQQIPYGKVTTYAHIAYLVGTPQRPRQVGVCMKHLPNDEEARFNSTNVPWQRVINSKGMVSLRSQPSGAANQAIELQREGVEVTRTAMGEYTVDLEVYGWFPEELTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS89</accession>
    <name>A0A2T4BS89_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ThrRS/AlaRS common domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1385363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS89"/>
    <dbReference type="STRING" id="983965.A0A2T4BS89"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000008">
        <property type="entry name" value="Similar to alanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="31460" checksum="BF76A19A34F3F0A0" modified="2018-07-18" version="1">MGSQSPAGTHLTFHHDGKLLTLKTELVSIRPFSALEEQNRAIFKDASDDDYVVVTKETIFHPQGGGQPSDEGTISAISSADDQTQTPIAINIRSVRMDVVNDGLVLHLGRFQDPPMADRLQPGDLVEQKIDAEKRLLYSRLHTAGHVLGSAVRHLLEKEIEGFDELKASHFPDSAACEFRGLIEGKWKQPIQDRVDEYIRRSMPVEIDFWTEDDFRREGLERLIPDKSLLPPGETKFRVVRIVGAEVYPCGGTHVDTTDLCGATTVKKIGRSKGISRVSYTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTN1</accession>
    <name>A0A2T4BTN1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">beta-glucosidase</fullName>
            <ecNumber evidence="16">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1340882</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="16"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTN1"/>
    <dbReference type="STRING" id="983965.A0A2T4BTN1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="18">
        <location>
            <begin position="810"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB72671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="890" mass="96600" checksum="49878E227385B554" modified="2018-07-18" version="1">MLPRRMRKSRCCIAVLAVIAIIVMLLAAAGAFGYKKLKITPLDGKSPPWYPTPKGGSVRQWADSYQKAAEMVARMTLPEKVNVTTGTGWSMGLAVGNTAPALLVGFPALALQDGPLGIRFADNATALPAGVTVGATWNRRLMYEHGRVHALEARGKGINALLGPCVGPLGRMPAGGRNWEGFGADPYLQGVAGYETIRGIQDQGVMATIKHFVANEQEHFRQAWEWVLPNALSSNIDDRTMHEIYAWPFGDAVKAGVASVMCSYNMVNNSYACGNSKLLNGILKDELGFQGFVMSDWLAQRSGVGSALAGLDMSMPGDGLRWQDGNSLWGPNLSRAVLNGSLPLERLNDMVVRIVAAWYQLGQDDEKLFDRKGPNFSSWTNDRMGVTAPGSSSPQEKVVVNHFVDVQANHSTLARQIAAEGTVLLKNEGVLPLSVDGHLGGGSGTNSTKREGQVRIGVFGEDAGPGKGPNYCEDRSCNQGTLASGWGSGAVEFPYLVSPIEALRKKFNKDKVKLTEHLKNDGLDTDVIKSQDICLVFINSDSGEGYRAWEGVRGDRNDLKPQKGGIALVTHVGLNCGNGSGTTIVILHSVGPVVVDPWIDMPGIKALVSANLPGQESGNALASILFGEENPSGKLPYTVGKSLSDYGPGGQVMYLPNGAVPQQDFSEGLYIDYRHFDKFNIEPRYEFGFGLSYTTFDYKNLKITETKPRSPLPDERPAPDVEPPSFDTAVPKPEEALFPSGIRRLKNYIYPYIESVKDVKVGQYPYPDGYDKEQPLSGAGGGEGGNPSLWDSHVTVSVDVTNTGKLGGKAVPQLYLSYPASETVDFPVRVLRGFDKLYIEKGETKTVEFSLTRRDLSYWDVERQNWVIPEGEYTFAVGESSRDLRVSGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTS2</accession>
    <name>A0A2T4BTS2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTS2"/>
    <dbReference type="OrthoDB" id="9970537at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="111" mass="12336" checksum="FCB0FEC89C5FF82F" modified="2018-07-18" version="1">MQQFEFHDPTTRSAWQQTTPGIEELILNEDKSTGRKTLLQRWQPGAANPGSSPSVHTFVEEVYIVEGDLTDKTLGQTFYKGMYAYRNPGMEHGPWSSEGGCLMFVTCSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU64</accession>
    <name>A0A2T4BU64_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1341242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU64"/>
    <dbReference type="STRING" id="983965.A0A2T4BU64"/>
    <dbReference type="OrthoDB" id="4900200at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015451954" evidence="2">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="210" mass="21482" checksum="4A7E849DA523EE71" modified="2018-07-18" version="1">MASRGVVLFAAMLGGAAALATATPADTAAICGIVCVDKVNECGEKYGGCYDPCLEAAPEEPPCTIPGTHIWYPTPPPSEVIPFTEGEDGDCSDIIVCIDGVNECGIPFGACIPDCKPWDITIPSCPPDATEPTETDGGDATDGGDGSDGGDETNEPVEAVPWQGAELPVPDEPVAGEPVPGEPLIGEPLIGEPVPDEIVPWDPSGSRGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUI5</accession>
    <name>A0A2T4BUI5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chitin synthase A</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Chitin-UDP acetyl-glucosaminyl transferase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Class-V chitin synthase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1340520</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BUI5"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000010">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000014">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0518">Myosin</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1395"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1432"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1460"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="19">
        <location>
            <begin position="1682"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1628"/>
            <end position="1648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB72981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1740" mass="193264" checksum="7442FB4F3FD15575" modified="2018-07-18" version="1">MASEARAGGGPQTTQVSTTTLLNAIHNIYLTSQPHQLDASTSVVVNTWLTAAQGSGHIAAAVASSLHQSTPSLLVPFLNSFPFAIPSSVYKALEAIQPLLRCVTPQNPAAQRQGGLGVTLSLNLAGNLTGATLALSQGGIDTEAGLLNIPAEAGYRAFDVFYYLLTSASTPAEREFLGLKSASAYALLARSGTYDPPSYLPTADDSAAADDFRQALKDIGIKGSAHRNFISTLAGLLKLGDTLDYDIESEALEEICEDVGGLLGIDPDVLQRQCSTEDRKTLVGGLYESLVDWVISKANAAIAAQLVRIKDGDESLDGHGVRTPTSNEDNGDTVAITVLEVPDPALGRALCMRSVFDDTQGINAEMINDGFEIPPAGSSILREVQQAVSEVAADLGVPSPQTRERQHALEKREVVLEKAAYGADDGSFLKSLLFPVEGQGINLGRAGRISLPTVLSSNRLWYHLCLHPTDDSPASLAALPSITSAWSAGTVSRQLRSWRLPEWANRRHRNLDFTADFDVDEFVQRYAPLGCRDGREGIETWILERGWTNGEVFIGKERIWIRDSAWWEAESMLDVKPGDEIHPIHSNPFNTGFDTGYSAGNGSGYFPPAGVDNMASASRDQLHHRGMSQGNMSQLTLGQAQTPQAAPSIAPSAMRSGDYGLGNKGDLYRGDGFYNPEAAPFVDAEMAENKQLETKEVDNARRAWVWFTWAMTWWVPSPLLRWIGGMKRPDVRMAWREKLALCMIIALINAIIIFWIVGFGRVLCPNMDKAWDRKQVATHQGTNDFYVSVRGSVYDITKFWKQQHSDTNIKTTSDNMLPLAGMDMDDYFPPPLSVACPGLGVPDTLQLVNNNTVEYSLAVHTSGRFQPDPTSKLADPNWYWNVFQPAMDEFYKGQLVYTKKDVQKQGDEQQRKWAMYGDQIYDLTNYFHTLDVYNNDKRYTFLNKDVTDLWNDNPGTNIKEKLDIILNDPNNNSTVHANLENSWLCIQRVFLKGYTDFRVTPRCVVNNWILLSFTIVLCIVIGLKFISALQFSTKRKPSPQDKFVICQVPAYTEGEDSLRKALDSLTALQYDNKRKLICIICDGMVVGGGNDRPTPKIVLDILGVDPKVDPPALAFRAVGPGSDQLNYAKVYSGLYEYEGNVVPYLVVVKVGKESEQTKAKPGNRGKRDSQILLMSFLNRVHHRSPMNPLELEMFNQINNVIGVDPELYEYLLMVDADTCVQEDSLNRLVAACAHNAKIAGICGETSLENDQKSWWTMIQVYEYYISHHMAKAFESLFGSVTCLPGCFTMYRLRTADKGKPLIISDQVIRDYSVCDVDTLHQKNLLSLGEDRYLTTLMTKHFPSMQFKFLPHAQCKTAAPESWSVLLSQRRRWINSTIHNLVELLRLKDMCGFCFFGMRFIVFIDLFGTIILPATCAYLGYMIYSVATHPTSFPLWSLVILAAVYGLQALIFILKRQWQHIGWMIIYILAYPIYSFALPVYSFWNQDNFSWGNTRVVIGEKGNKQVVAVDDEGFNPASIPLQRWDDYALMNGLPGRRGNYFAHEKQDMGFDQYEMDEMKSVYSAGPQGSVLTGMQGRNTYMPPQPHSPAPFAASQMGDPSYMQHRQSMMSMGTAIQDRSQSPYSDFPQRPNVMHTRGPSNLTLTPSPGLGGMNRSSSAMSFGRGHEAARSTASFDFMGAAGGVASDAAIIEAIQAVLRDVDLDTVTKKQVRALVEQRLQTELVGERRTFVDKQIDRELENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUK4</accession>
    <name>A0A2T4BUK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1394720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUK4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUK4"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="300" mass="32471" checksum="1E78A147039AE6FE" modified="2018-07-18" version="1">MLFAAKTLEGIRSHRAKTSASIDQTTHLPPKQRQQQQQHALSQPPQEPPTRLSTPSTPHRSLRRTPKFDSAPTPTPTFTSKPQPERRVHIAAASAGFYPSIVSLADSDSSITGLGLSLFDEADGEKHQQSQTQQRSREDPPGTANPPNPETSSDVAQPRLKTPRISKHTHDAILFALEEALRGPHPFTADEVEESASMSDLMTGGHPANGAALAPGSDLDPEDYDTPATTNPSGANMPSSTSGPQPQWTGAYSNPQDYSGQGYGTPGWDTVPRHHHPTRLSDVMEEEDERSRTSASQSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV15</accession>
    <name>A0A2T4BV15_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1472428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV15"/>
    <dbReference type="STRING" id="983965.A0A2T4BV15"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="593"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="817"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="949"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="820"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="982"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1096" mass="120149" checksum="B08B9037AA1304E8" modified="2018-07-18" version="1">MAEPAQVQTAPAGSPREIKQEHEHDHTAVLEGLDFSLLAELASKRPFEQVAQDSHEEREQEQEQEAKRPKTENPHPIPNHSTEEESSLEDGLALLVQNALSNVGDLVRGFTVDAAEAHSDPMDVDDAHGADARPAPVSFLSEPEKYVRIANTHALGNLALSVLLILLQQPIDDMSKLAGDADSGYGRSYGRLKRSFDATWQLFSDGQVLSADELEIQEAEARTLLELANIAKFGMWLVEGGLDSFAAAERNFTCVFRCQVSDLSPALSQLYVEMRTYKTIETLIKDGEGLSIEEVARVVQTTMLDGLEESPAGEPMSASLQELLTLAKARKDVMEEELKVKQPAALKEKFPPGDVLKSFSAHVRTLLASMTEVGEKLGVSALLSDVANQESIPSGSGDGDLDLDDLSSFFEKTTSGLVQNALAGLTEETPAEESPVVDITETTAETTNGEPKSDAAATTPAPQTNGAKLDLISDYKELEALVAESTSNYVKTTLNGLSAVAYQPTVPQSTAETMAAQSPYLSHLHQHQSHHPYYTSYASQPPPEQQPQQPAGSSDNLPPNQTFPSAILYDKARQAALSKSSAHTRREGLHSTRRPWTQEEEKALMAGLDMVKGPHWSQILTLFGQNGTISDILKDRTQVQLKDKARNLKLFFLKTNSEMPYYLQAVTGELKTRAPTQAARKEAEERARMNSEEEQAKLQGIMALAGGLQHPPQQHQHQHQHQHQHQHQHQHQQRQPLHHQARPPVTVAAAVGQSVVTPAQAASAAQSASSGQQQQHASHLHHHTPTATMTSTPQANLAPIQRGGIILPNTAQIKPDSHLAAAQQASQHVPLAPQRPQAQLAPQVPMAQAQPQAQPQPQVQMQQQQQQQAQQHRNLNPKYNLKLRCLKPKCPKPKCPKPKCPKPKCPKPKCSLKPRYNLNLKRPKPKFSRNPKYNLNLKRLNHRCSLKYKHTLNQPNPRNSRYNSSITNPSHHPISNRRNRQLPRSTSKQPRLQNGTAPHPSPTPTIPSTPTPSHLSQHISTPLQPSPAPTYSPQPQQQQQQQQQQQPSVSAQSELHKLVSAPEATMAQTAVQDDEAAAEAALLEGLQAAVAQALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVD1</accession>
    <name>A0A2T4BVD1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1340618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVD1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="507" mass="54435" checksum="ED17C9B724FE9A8B" modified="2018-07-18" version="1">MPAAEPTAVEKPSTSFSVTTPSSPTFTNTPPSNHNVSSSPADDSENSKGEDGFPRVVEVGQYDAEAQQGDPDQDQSYHLPPVDTGKDAWLFLAACFVMEAMVWGFPFAFGIFQDYYRTHEPFAGSSKTAIIGTCAMGIMYLDAPLVFVFARIFPRAGRWNPTIGLLMMCAALALSSFSETTTHLILTQGALYGIGGSIAYNPCLMYVDEWFDRRKGLAFGLMWSGTGLGGFTIPLVLEALLQRYGFRVTLRIWAIALFAFTMPLVYFVKPRLPPAMTAHIKPLDWSFMKNRVFALYQLGNVLEGLGFFLPGIFLPTYARDVLGANSFASAATLLVLNVGSVVGPITMGTLVDRLHVTTCILISTVGAVSGVLLLWGLGSNIGILYVFCLVYGIFAGSFTTSWPGIMRHVIKVAATADPETSSVEERSGSVGTSRYDPLMVIGFLSIGRGVGNIASGPLSEALVKGMPWQGQAIGGYGSGYGILIVFTGATALLGCVSYAGKKFGWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVD6</accession>
    <name>A0A2T4BVD6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1425221</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVD6"/>
    <dbReference type="STRING" id="983965.A0A2T4BVD6"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="12">
        <location>
            <begin position="404"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="883"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB73268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="978" mass="108998" checksum="30B2FC1ACADA6445" modified="2018-07-18" version="1">MAISWKSFDFFDVSQVALPDDDTRQLFESNDVSSVCAGSDSLFLGSSDGYVSIVGKGWKVIRRFQAHEARITHMRQVEGTSLLVTIAEDMSSEPTLKAWALDKLVKKTNMPTCLSTLTINNGRRQFPISAFAALDDLTQIAVGFANGAVTVIRGDLVHDLGTKQRIVYESEEPVTGVQLTTQDTSTTLFISTTSRILQLALSKRGQGSPPKTIEDSGCAAGCMTIDPRTEDVVVARDDAIYTYRLDGRGPPRAYESPKRLVAMHGDYIAVAGPSSVSSSRDPEALRRRFGSATADGLFNAWTFVLLEPDLRVIGHTETLISPVRFITEVWGDLFTITEEGKIYRYHEKPLQQRLEMLYQRNMYPLAIELAQNSGMDAEQQSLIYRRFGDHLYQKGDYDGAMNQYIKAIDATEPSQVIRKFLDTQRIHNLILYLEKLHHHGKATSDHTTLLLNCYAKLKDIKKLEEFIMAPGDLKFDLDTAITMCRQGGYYQQAAYLAKKHGETELVVDILIEDSKNYDEALDYIWHQDPAVAYPCMQKYARVLIEHCPKNATKLFVDYYTSNYRPRRTVVLPVEASGTATGSTGFTAGAASAVQNLTNLLVLPSYISPTTGTPGGAKPNETVVVPDEDDILIPKYTPPPPRTAFSSFIDHPDEFITFLEACLEEEKLRAAHSTDLYTTLFEMYLHKANEKKGSLHKEEWEAKAKKLIEGEHVPMESSNVLLLSHLSNFQDGTVLVKEQAGLLSDIFRSYTSAKDTRGALKALRKYGPEEPELYPAALAYLTSDPRVLEEAGPDELAAILAKIDKDGLMAPLQVVQTLVGQTSGGGVATMGMIKPYLRDTITRERKEIAQNRHRITTLRTDTEKRRSDLEDLASKPAVFQATRCSDCGQGLDLPAVHFMCKHSFHQRCLRGGGEDAEIECPKCAGENEVIRKMREGQRERAGRHDLFKADLENSSDRFATIAEWFSRGVMDAQGSEQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVT3</accession>
    <name>A0A2T4BVT3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1394001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVT3"/>
    <dbReference type="STRING" id="983965.A0A2T4BVT3"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116966" checksum="C679C83AFAED5989" modified="2018-07-18" version="1">MSFAIEVPGDAAPLSLQELCRTLHAATSSSDHVQRQAAGQQLATWESQAGYYSSLQSVFLDKSLPLEIRFLAIIQIKNGIDKNWRFSHSKQGITPEEKNLIRSRLFQGTVEEEVRHLALHNALVIAKVVRVDYPDDWPEALPSIVHLLRSTRNGNQHHLHGTLVLLLRVIKEMGSARLRKSQTALQSITPEFVYILSEIYSEKSSQWINFLSTGQGDGDEASLAMENSLSALKTLRRLINVGYARPHDDSSVTQFWTLSQNQFGQFLGFVNHESAVPAPYQELVGKHLLQFAKFHIDQAEHFVASFAFLPNSISLVNAYWDLISNFAEIYVSSGGIRQGSGDAGSKAKKEGPLIEKLALKGLILLRACVRMAFQAVQTFKYRSPETKAEQEQAKEIIRNELFKDDLVIQIVNTIISHLFVFRQSDLEAWEEDPEDWELQEQLESSAYEWEVRPCAEKLFLDLLTNFKPLLVPPLLSYFQTAQSPQADIATKEAVYTAMGLSAAHVSSAFDFDAILATTIVNDAQQQGGLYKVLRRRIAILISQWAPVRLAESSRPIVYQIFQHFLSSNDETNDIVVRITAARQLRWVADELDFSATAFLPYTSDVLNALTELVQNVESDETKLAILESIRILVTRMEEQVAQFGDQLMLALPSVWEASGPEEYMIKQAVIAIFSALVMSMGPNSQRYQQSMLPLLAEAARPGSDLHLNLIDESLELWNSILSQSNPPLARELIDLVELLLPLLEYSSDVVSLALQAIESYILIAPEAMLEDRFRRPILMALSTSLDSKSREHVRLGTTSIELLIRSAAELGGAEGVSVIIQDMVETGFVNKLVANLHDAWEARQTTGPNKRASRLSTVTQGDYFAILARLLLAEPNLFVQMLGSVGNVQEVWAWLSSEWFSYQSGMDNLERQKLYLLGLTRLLELGSPMQELVLDRLQDYLDMWTNLIMELQDNAGPGNDCLIWAGEPEVYDYDTPKMILEKQSQHKDPVHCVNALQFVKVRLQDVVGRIGGEAVFQENYVDNVDKAVMDAFQKMLNEVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW82</accession>
    <name>A0A2T4BW82_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="18" type="ORF">M440DRAFT_1441156</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW82"/>
    <dbReference type="STRING" id="983965.A0A2T4BW82"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="27"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB73555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="877" mass="98338" checksum="CDB011F74E0CB302" modified="2018-07-18" version="1">MYEEAPPPVRSSATLPQMPRRWLSDEWSFGDYFKKDAIEMAWELLTKVYGLDPARLYVTYFEGNPALNLEPDLEAKELWKSVGVPEDQILPGNMKDNFWEMGDQGPCGPCSEVHYDKIGGRNAARLVNMDDPMVVEIWNLVFMQFDRQKDGSLKPLPAKHIDTGMGFERLVSALQNTASNYATDCFTPLFKQIEQVTGARPYTDKYGADDVDGIDTAYRVVADHIRTMSFAITDGAVPNNDGRGYVIRRILRRGVRYARKYLNAEIGSFFSKILPALVEQMGEQFPDLAKKQADIKEILDEEEEAFSRTLDRGEAQFERYAAKAAKDNIKKLDGDVVWRLYDTFGFPVDLTKLMAEERGLEIDEAEVAVAREKAREASKAVKDSVQTFAKLDVHKIAELDTDLKVPRTNDDAKYLKGDSKGKVQYIFDGKAFLKSTKDIPPNTAIGVLLDQTNFYAESGGQVADTGRIVIDDVVEFKVMDVQDFGGYILHSGYIEYGELSSGDEVICEYDELRRSPIRNNHTGTHILNHSLREVLGDDVHQKGSLVDNEKLRFDFSHKTQVKLDELKKIEELSNQDIRANAKIYSKEVELDRALQIEGLRAVFGETYPNPVRVVSIGMDVDTLLADPKKPEWRKYSVEFCGGTHVEQTGLIKDLVIVEESGIAKGIRRIIAYTGEAAHQVQREAKLFEQKLDELDRLPFGPEKEAQVKAVSQELSQLVISTLTKDEFNQRFQKIANAVVAEQKKKQKAESKTAADVVAKHFETNKDSKYFVGRLPISANAKAVGEVIKYYQSKDKEKSVYVFVGGAEEGAVAHGVYVGTHLSSKGVTAEQWAASVSEVIGGRSGGKEPSRQGQGTQPEKIDDAVETARKWLDEKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWH6</accession>
    <name>A0A2T4BWH6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mating type pheromone G-protein coupled receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_29766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWH6"/>
    <dbReference type="STRING" id="983965.A0A2T4BWH6"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14939">
        <property type="entry name" value="7tmD_STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32249" checksum="A48B1C7F259C3BE2" modified="2018-07-18" version="1" fragment="single">FNPYTQNITILLSPSAPPISIPIPLIDAFNDETVSIITNYAAQLGAALAMLLVLLAATPPSRLLRPGTPLVHALALLVCVVRTVLLIYFFLTPFSHFYQVWTGDFSQIPAWNYRASIAGTVLSTLLTIVTDAALVNQAWTMVSLFAPRTKRIVCLFSVLVALLAISFRVAYTVIQCESIAALAAPRRFAWLIRATLLLNIGSIGWFCALFNSKLVSHLVTNRGVLPSRRAMSPMEVLIMANGILMIVPVIFAILEWHHFINFESGSLTPTSIAIILPLSSLAAQRIATSPSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXH3</accession>
    <name>A0A2T4BXH3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1338670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXH3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXH3"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="75"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="425" mass="46321" checksum="702F102E7EDC44BE" modified="2018-07-18" version="1">MAGDNDRVCPAHFLENKTIVVAGAGLAGSAFVVGLQKLWSPSLVRPNIIIYERDAQDVAARRETYNLSLTGYDDNGGLVALKHLGLLDEALGHAASGVDGAGAFKIWDTQWRGQVAFRRKPAPGIPSSSIRIAREDVRQVLHDSIHSSDQCIIHWESQCLSAISLTDGRLRVRVVRGNGDVSEQDCDILVVADGASSKVRQSLRPDDCLGYNGAVLRGGVASFEESLPPQLSEDWGFVISRTGVSAFVSPIDKHKILWTVGQMGDRVPPLDRGCLDQAQAVIDDSLELASHIAEPFASIVKRTDPKTVLLLNSRDKTPFRHGEIATVPAIFLGDSNHALSPFAGIGANLALADGWELASQMCKHRSLGEAVRAYDDVSVPRAAQSLRRSRRVINTAHSTGWQYYLFWCMLYVGRFVRWISSKMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXK7</accession>
    <name>A0A2T4BXK7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1339115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXK7"/>
    <dbReference type="STRING" id="983965.A0A2T4BXK7"/>
    <dbReference type="OrthoDB" id="407477at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015599128" description="S-adenosyl-L-methionine-dependent methyltransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28490" checksum="741B4335FF047DB3" modified="2018-07-18" version="1">MSGTRSLYLVFAIAASLFVYAACHQWGSVTAEAIHERFGSQIFEQTAQKYGTDKVTTHKYQFMYDKYLSGVREEEIKVLEIGLGCNMDYGPGASYYTWLEYLPFVDLYFIEYDAQCAQKYQDKTANAHVFIGDQADVVFLTKFAAEATAGGLFDVIIDDGGHTMAQQITSLENLWRAVKPGGLYVIEDLQTSYWEAFGGDPAGRRSSKETTMTYVFQLIDDLMIGRSETKMSHEVLSIDCMAEICALRKKESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXQ0</accession>
    <name>A0A2T4BXQ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1338267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXQ0"/>
    <dbReference type="STRING" id="983965.A0A2T4BXQ0"/>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
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        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1213" mass="129779" checksum="45B9639DDCAA3B28" modified="2018-07-18" version="1">MFKMSRRRAHSVQPLTKETADPTAATAAASAFMRGHSTAQPSLSSAAAAAALRAQPSPPTNVAEVSSKRVQRRASSLSSPAGRDRGKGKPQRSPSVGSMSERTFRSPSPGGRTPPGKQDVPPVPSIPATRSAASPLRTQNFQTASQKSAAHQQQGAWFGPATQHAYQDPRMETARKVTPELPESRSGSVNSSINFSYPRPRMTSYDSHTTSEPDLVYDPNSRRMVPRVSLVQVSPEIDDTATTTPQKAKGSKPVKQRHLPQEPSREARPLIPEDFQPEPLSTKTGQHRTPDVSIGRSSPTASSTSNLPTSTTVTETLPQEEGFEIESPSNWHDKNATSDEPQEPLAESNPKPDPPKWDNVKVEPPFSYAASGSSETSVRSAHFATSTDRFVVKHEPPPRSLSPRKSALKSAVSGKANHDENSESSIPGTSLARKDLSPPHRKGARVSWNDNGIVVVAEPGTSEEPGLAGVHNLQPQYNKEGGALEGLKGSKASSLQQDELMSPRPALPLFGSIRDKKGKEPEERQLVRPRERSLSPQSQQLSSPHVISIMPDQDNTAADGVKPSHPSRAQASRNAANISKFREPLPAIIASTESLGQESEELLSSEDELYEDVPTGAEQGRIKKPSKALSSNSELLSESSPKEASKVIPKTANGSLGGSGSDTIPPATDREVAPATKSSPLPGSFPLDDDVSGVGMDSTSKSLTPGISQASEHEAGNQDRPAKDTHGEDDSDMDSIYSDAFEDLSEAGDDGFMSLDAALVSSPVASAGGNNSSFGARHDAKLWDGVVSGSSQSPDDWERTKAYWKSLTAEERRRLELEALMEGDDDAARERSPVKNSKSLGDISEYPLTSAQKSQIRQLQREELSGADPASLEGTRQASAAPAATGTTGSRSGIPADGQRTRAKKGTPEVKNGQQPLKQTDFASKASLPGPAGRKRLTLRSLSPTTSHTKRSSVASAGPSRPVFESQTHRSVRHSSVEPYISRFSLRNGTQRTYGDHLSDSSDDDFMNTTPLTDGSLIGDEHEPAHSKFMHSIFHKSARHTPPDSSSSANAGFTSRHDAERLRGERLQADGSAHLPPDQLSGQGSKAAAAASASSRRQGLISTLRRRKTNDAGGGHNVILQHHQEDTRAAGWPLQNTDGEAREASMTSPAGDSGRRSAANGALVADDLTSEPRHPHELPHFGGSSDANHANPLSQEPKRKKFNSLRKMFKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXY9</accession>
    <name>A0A2T4BXY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1380751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BXY9"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="608"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1238"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1703" mass="186117" checksum="09B3988170BD6EB9" modified="2018-07-18" version="1">MAIDGDGYGDLPSAKLSLTSSIATAMDTSNEVAKTPTAEPTTQSGVASSVDLEQLWTWNQHVPPYIQRCMHDIISEQVQQHPHKVAVESWDGSLTYQELDSLSSQLARQILQKNAGLGTRIPLCFEKSMWTVVAVLAVMKAGATFSLTDPSQPVARLQTIVEQTGADLIITSVAQSELGKEISRPGGQVLAISRDYFHGIKEPDAETALPQVPAETPMYIIFTSGSTGKPKGVIITHGNYTSGAIPRAEAVGYKDTSRCFDFPSYAFDVSIDCMLCTLATGGQICVPSEEARMNDLSGAIRQSKANMVHMTPSVARVLDPDIIPSLDVLGLGGEAVSASDAAAWSQHTSLIIAYGPSECTVGCTINNQVTISTGIGKGVGGVTWIVDPDDHNVLMPVGAVGELIIEGPVVGVGYLDEPEKTAEVFIENPSWLVSGHNGFPGRPGRLYKTGDLVRYESNGSGSIEFVGRKDQQVKLRGQRVELTEVEHHLRACLPSGIKVAAEVIKPENGGAPSLVAFLSESASSGVTGVDPAIVEPSPELKSALANVNAAMGSRVPRYMVPAAFVTLQHMPSLVSGKTDRKKLREIGSAIPREIFSRMQAPEAQEEEEPETETEKKLQSAWAKVLGSDANIYRKSNFFALGGDSLRAMRLVVTARENGIALTVADIFTNPTLGNMASKATRVSESSVDDVPPFSLLEKDWREETARNEISALCGVEASAVEDAYACTPLQEALMALSAKVKEAYVAQRVVWLKDMATAEKLIAAFDAVQQDSPILRTRIVQIPGRGLVQAVIKGRLTRFLGTDLDEYLVNDRNEPMELGRPLVRYAVIDDSTTGKVSFVLTIHHALYDGWSMPLIVERVNKAYTGQTMSRPAAFKHFIKYLLTMEADKSASYWREQLSGANAFQFPPIPWQGYQPQSDSLLEEYVPLPAGRASNATTATVIRAAWALVASQYINSTDVIFGETLTGRNAPIVGAEEIEGPMITTVPVRVQIDRDMQVSDYLQIIQEQTVEQIPHEHFGLQHIRRLSPDAYEACELKTGLVLHPSAEADESSESDDLPASRLVPAGDAEAAQEALKFNTYPLMLVCSMDPRGFLTMASFDSKTVSVPVMQRALNKFRQIAQRLCDESSSTLSSLQSTLLDEDVGELQDTILNADVSDASKAFPGAQAAFIADAADPNRLVPLSAVGELIIQCPDELPGLTEISAPSWLEAKPIRIKLIDTSSEKIAQAASTGVTKSRISATSSRQRKLRSLWARVLRLSEEDIGLNDGFFVLGGDSIAAMKLVSEARLEGIKLSVVQIFQKRTLYEMASAMEEVEKPASSADAATTREKTLKPFSLLSQQDEDSKRRFVNDIIAPQLADPSWRISNVLPTRPLQQIAVRGTTQLPRFSARYELMYFDKAINRDKMIRSCNELVARNEILRTVFTEHNDEGYAVVLEELVPSFVEYAIDGDIEAFAHQLCRLDALTKMPLGSSFVKWFLVESSSGQSCLVFRLSHAQYDEICLPIILQQLSALYEDEPVQETVPFSAYVHHVLSKNIPASIPYWTDLLQGSSLTVLKPDIPVQQRNHFAIQQTVDISSRLRDITVASLPTAAWALCLARRLSLRDVPSDLWFDSVVHQDVEHVENLAFAAAGSGRLETVYPHEEPLREWKIQAFVHDGSSKLTLEIVTFESWGGFARGLLDDLVDAVDTLLKDPRAKLFEDDLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYE8</accession>
    <name>A0A2T4BYE8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1380964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYE8"/>
    <dbReference type="STRING" id="983965.A0A2T4BYE8"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="381" mass="43772" checksum="BDD01433239BAD5D" modified="2018-07-18" version="1">MPRRIFKNLVIATAGPLPGQLTTENLRQWTVLRKGVFTEDFDGQVTHLLCTREQFDQKLPRIKEALARGKKQHIVHCDWFEISAVNDKKLPEREYSMRNILAKQNAVKREQARIERGKREGERAVNTNLFHIYTDRAFFSYQIDITRDDTKTGDLGQRYTLYLWESNAKPHLYWFAAKFIKKKGASQPSFHRPSPCSGPWRREMDLFMDFFRIKTGIEWQDRVIGQGTMSSSYFQYSPPTGGKPVGRRLRFCYEYCLEVNAQLRGLPRPPVEEAPVEGEDGATEPQDGAGQEHNDDGIAQNDPALGSESGMPSDDDVNADAVEMVISMDEGEDEEQEGHEKQDGYEEQEEQEEHEEEIELQEFEEMQTAMSDSDVSTTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYN5</accession>
    <name>A0A2T4BYN5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_116951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYN5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="18534" checksum="98A67D32D34BC989" modified="2018-07-18" version="1">MESPRTYQSGMSSAQTDFLGLGAVELALQRERIGLPSNAPRATTPRPYEGGLDVAPPYRPRDCASQAAPRSPQPHVMQYFEDTRVVACAQENSAPPRALASFWSAIRLIFFSRLPSRLKTRRPFSSLLSHNANPPKHKPLISISLFFLFIPHISSRHFVFPWSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYW6</accession>
    <name>A0A2T4BYW6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AHC1-like C2H2 zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1424263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYW6"/>
    <dbReference type="STRING" id="983965.A0A2T4BYW6"/>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="602" mass="64322" checksum="AE85EA82F777E48B" modified="2018-07-18" version="1">MDGGPRKRLHRDVESDDDDAMNYAASAKRPRTGSEALATESSSSKPQSSPRSMAVESSAAERARDLIQAEFCQEILLKHQELRLINQELAKCQIALEQLRRCHLIPYPVNCPTPQQMLDVSDGKGPAVVAKAGEAVPRWAPPFGVVDGPYSRHYAKWLIPDPAFDGIQPALPPVTARGSISEGRTTRNSNGEVGIGIVKGRRGNGSQKFESLSSGYPPPKDKAGPCVLTRADGQTVKLVCLDCHRDNFSSTQGFINHCRIAHKRDFKSHEEAAVHCGQPYEAPQGGNIPKDNKATAPAAPPVSTSATAASPFVHAFARPDMAEQEIFKSLRMRISDSLKLYNQGKLSVVKFPSNINAVSYPGKASASASASASAPDFGPSADAPHLSRLLKARNFRGNLHDVVADAKAKIPIEDVAGEESEVDGSVSPTQDAPPARASVVMRMPARTAKTPISTGSSARPTSSKGRAAHMVLASPSDSDMTAMANRHRSDAALSDEDADMEDADMSPNTLVSNNAPSLVSDDGEYDDSDEGSSVSGASDQLEAESVSDVAEITLDYETDPRTLRRGSTGMTGPVRLRKEASKQVTFIGPVKSGAQERRHRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ21</accession>
    <name>A0A2T4BZ21_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1336972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BZ21"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="743"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1485"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1504" mass="168669" checksum="8817571F650E8E7C" modified="2018-07-18" version="1">MNSQNLHGHGGGAPYDREREMDERHRAIQQHEEMARRDQERERERERERDSDRYPPAPHQSSAGSIPIHQPVASRISGAIHSPGGLLANHNGNAPPISLGAPPGPLNSFGGPLQSEHARPIQHGGPGGANGQHQMFASISHTQPPPNGSQAAPGGGIFGGPLQPQHPQEGGRGGQQNATMVGVAPGGHQMPGGITQGQQPILNVSFGNFSFLASAPYFDFPTGVRDVVTAFVGGGERLILACRDDTRLWGFYHYFHDALTYLDQVKVQFHDQPDVYNRFLDIMKDFKSQAIDTPGVINRVSELFAGHPNLIQGFNTFLPPGYRIECGAGNDPNTIRVTTPMGTTVQSIAGRGPQPDGHGLAVGGQPLFPERGGQWQQRPQHSIESPEAAFSTPVQNGANLFVQAATQGGAFDGPGGHQQRNPPQMPGSGGPPGGPNSRSAHTPMPASGPGAVNGGAANPANMERRGPVEFNHAISYVNKIKNRFQDKPEIYKQFLEILQTYQREQKPIQDVYAQVTTLFNSAPDLLEDFKQFLPESAGQARAPPGRQDDGAAAGSSHTPQPGMRDGQKMPPLGSFPPPVSAAKDNKKRPRTDKQTPTPGALLAEPPTSARLPPQNINGSKRPKLSHVRGSGDGASIEPTLTPVMPEPYPPRSPATSNQEEIAFFERVKKYLSNRSSMNEFLKLCNLFSQNIIDKNTLYHKGALFIGASPDLMSFWKAFVGVDSPDVVIDNKPAPPVEKVSLSNCRGYGPSYRLLPKRERLKPCSGRDELCNSVLNDDWASHPTWASEDSGFVAHRKNQFEEGLHRIEEERHDYDFNIEANLKCIQLLEPIAQQMLAMSPAEREAFHMPSALAGQSTSIFKRICKKIYGDRGIDVVNDMYTHPFDVVPVLLARMKQKDEEWRFSQREWEKVWHAQTHNMHLKSLDHMGILVKSTDKRNLTAKHLVDVIKTKHEEQRRERILKGKAPRHQFVWDFKDKEVVLDLLRLMMLYSMHNGQHSGQEKERILDFFETFVPTFFDLPEDVVQERIPKMQPDSGEEEIEDQTPAELTNGRSRRNGKKGDLLRGVLDPGRNGSKPRTQKEDSAASGSKETTPEVGSANEEEMADANDDTAVPEVSNERWMPTIPKPVVVGDSDNALLDADGELKADGFFTRPWYNFFCNQTIFVFFSIFQTLYSRLLDIKDSKEAVAAEIERLNKPKPARDLGFTENHMTFFDANEEPAKFWPKTLELIEDYITGDVDENRYQDVMRHYYLKNGWKLYTIQDLLKTLCRLALTCKSLDAKEKTPDLIQQYLINREREETSYQTEISARKFAEKCVKDGDLFVICWFPQKSEATVRWLQRDETTFYMDEMQTRDKWQYYISSYVRVEPTEGVPRAKLQKVVLTRNLPSGDSESDEDAIPKPVSYKEDLTVSICLKSSKMIWAPGTSEYFIYDQAPKTKEQREHREKFIKALSNYRELKFSEKMIHNPVWAKDMSPEEVQEQNKNFRKWMDEGIPPPASNEDVDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ40</accession>
    <name>A0A2T4BZ40_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ40"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015768855" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8706" checksum="7490F6589D1451EC" modified="2018-07-18" version="1">MAPWLSAPTSLLLMPAMRFTVGGATRCLWRIFVRYIKADGNSFQCNHSSQWRWEPPGPLSDRRHGVCGQPHRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZN0</accession>
    <name>A0A2T4BZN0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1337066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZN0"/>
    <dbReference type="STRING" id="983965.A0A2T4BZN0"/>
    <dbReference type="OrthoDB" id="5408998at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="769" mass="82847" checksum="453BD990AFB5D05D" modified="2018-07-18" version="1">MASNNTNGDDDANHLNDNHLHVQPDSAPPPPYTETDLLSNSGSSRSPHPPPPAAAATTPSHSFIDDAASSTAGETIYTPPLTPRTSPSTSAQPAASLYFELRPSPLSETVRGNVILHTIVVNDASRPEDFPYVTEWANRDVTALDWSTFINFLIPDHSARQNEAVMHRKLLDEIQSESARAAAMSTLQAEGQVAGDEKTASSSSPQASAQRRREAEATVQQWNEGFFGPRGIQIAIEVPRAPEAQMPGGWEAEFDRAFPGPSARAQQRAGRSAPGGCSSWGNWQVDSNGVRYGNGFVADQNGLRIGNLVMDHHGIRYENSAAAQNQQRPGDASADATRDFRGRTAYQYGNRDEKRSSSVSSTSSSSSSSSESSIGSLPSYDDVPLSSAQLYINRLQDWTKNPDQLRTRADVKQLKAELKSIPKSQDNSLEMDKKALRAQIKTLTTAWRQIKKQQRKERRARRQERHAKRRAERKERRQLKREMKKARRDARRGTATPVPHPAPGGPPVPPHTAPDVPPPPSGPPPPFTGGFPWGRPGRGGRGGRHHHDHHHHHGPPRNMGWGSRPPHPPHHPHPPPHGRGSPGDHGLLGGMFGAGGPLGPGGPLGPGGPFGPGGPFGPAGPFGEKGPFGGKGPFGERGLFGGGGPFGSNGFFGSKQQFHQQHQQQQQGVEPSTTSVPGSWPDEKRNPATRPPPQDDDQGIPPPGPVAAAKYRAMEGIETAIQHQVAALATAEPGSSQREGLEKALEELNKKLEAMRVEADEEYARELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZU6</accession>
    <name>A0A2T4BZU6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1036146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZU6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="86" mass="9324" checksum="BE5FD5FE5818999A" modified="2018-07-18" version="1">MKPNKPSSSIFASFKQASTPTSKRRLIVDEPLHQSLLTYLDPSSHQRHTISVRSPSGTSPLGLAQPIPNESRAYCLSSIGCSEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C033</accession>
    <name>A0A2T4C033_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_104804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C033"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="17666" checksum="45FBD92DB82A0260" modified="2018-07-18" version="1">MEPGRAELCQGCSSEGPAPRVTSRYPLSCSSIQNLMRRGVQQVKHQAKRPRGGHGHGPQSGRESTLCDLQKGRSHVEMDGQTLQTLCGLARDPSPFGRVLSCCQRGAIEAPGEEPESRPSKPLLVETNQSPVAAVTHSGPIGLVGRSMALTARAAEPWRPCRVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C084</accession>
    <name>A0A2T4C084_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1378851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C084"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55607" checksum="9696C2240CA06FDF" modified="2018-07-18" version="1">MMDKMMDKDNRAAEPQNRPAPRRGPGRPRMSENAQETPIEEARKTRMRLAQRSYRSRKQSALISAKARAEVLEVALDGSIDEFIKFYEHVSQRGDELPEGLMTQLNQTAINIMSIARRAAREKSMLAGEQDRAPDQGAADVAEESDEDHEPEDQPTCIPAAETHTTQNRPLKEQYEPFTDDKPAPISQRLMLACLIRAISLLQLGEFSFVAVSPAMLLPLQLERAERLLEKVAHRLSGSPSIFSADCKYGDGRNVCLPKLMRLIEGNLDTLTPRLSPPDLQSLQFGRTRTMLDTAISDLQGEWLEAPDVEEYLEQRGIFVRMGSSGDVISLSAPMHDDEPPLRPSASSIHDPHSVHKPPLHTMDDMSSTQRAVYPNQAVNMPESDLYTLGRHIAPGGISRRPAPLPEHDFTIFGKLFLDDQAIRTGYNGVSLSDWYPEMRNLADDAGSSQHAWGSRKVIIDIGMLIQGLADKAVCLGPCPGIRRIHVDEAIRGSVSNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0K8</accession>
    <name>A0A2T4C0K8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1379047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0K8"/>
    <dbReference type="STRING" id="983965.A0A2T4C0K8"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="288" mass="31522" checksum="1E1C23D3290C909B" modified="2018-07-18" version="1">MAEDACPVDHKTRDAWLAQARAAEASKTQLPSSTTSPSPSQPHSQPSQCPVDHSSSSSSAKQSSWTQTISSYIWSTPSPTHPTIPSSSTPPRPSTLETSRITSSIPRSFTPLDESCPVDHGASANPPSNAELESGADAASGNWVYPSEKMFFEAMKRKGYDAREVDMKTVVPIHNAVNERAWQQIKEWEAPYLAESKCSGPKLASFANKSTRMTPTARINTILGYTAPFDRHDWVIDRCGVRVDYVIDFYAGRPGGTTGAPSFYLDVRPKLNTLEGVKMRVMRWTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0T3</accession>
    <name>A0A2T4C0T3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0T3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015628942" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16176" checksum="4ABF1C43DD3DF145" modified="2018-07-18" version="1" fragment="single">MLFGRKIFLNFLFLLTFLTHARLLWTIHSLHSQICSLHGIIAVRAHQKQVANTNMGRVEEYATLVNNTRDDLLERATLHLGRRDAFRQRETYRELPTCEVRRRCSRRHWLYMLAPLTSICHSSRAWTIAMLSPVDDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Z1</accession>
    <name>A0A2T4C0Z1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1336032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Z1"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Z1"/>
    <dbReference type="OrthoDB" id="5413703at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="388"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="758" mass="84508" checksum="C60659F14456A8EA" modified="2018-07-18" version="1">MPTAEATVLHGPLPSAHGNTASPTPRGGDEKMRSLHPSREHHHYQQQQQQRRDSQSSYYREQDKREGRSRRDEDREPARSSPASSSASFPYRDIIKSVLSVMTRSDLSALTSASAPAPSEKNQEKERERERDVKDKERNVEDVVRGLAMEEWNSRWLDELVAKVKGELNDTASDSSISDNGPPTPPLSDTSSKDSMKRYQPTVEDYDDSEDEASSIFERSFAAAAPQEDNNTTAQRKPLIRTSSSLSNASSDSSSSSSSSYSAASRASSSPSPTDKDSVPSPPSSVSSSSPPPRPTVRFADKQPPVIHYIPEPPEPEEPEDERERELERERDREREREHERERERERQYEHEREREPYHDPYQQPPLPSSSSSSSSLSNQRQSPAWTALFNERDEPTPALGRFLRGVANYIIAEYAPIDSLVITPDKLFKFYTRYRLDNEFFPFQRVFDTRYHKSLRGISFLFTDLRCEHHLVQHSIASKPCIPALTPTGFEDWMTLMIRAFPDREARRLDLVLADVPLFSDDRTSSSRSSPSYGQRLPRELPRELFPERGHARAFDLLASSFAEWKSITSVVVPPPEPTSTSSSLPPPSSTSTSTSSSSSSHLHLHPAHTYATSSLIPPSLQKLPPAATKALKEDTRRHKDACYIDQSRIRPSSSLIYPCSSSSLPSSPSSSFTTAGAPLASSSSEAKGAEGIVVSSAASSSGSSSSSSGSSSGSKHRSREREARHRGASERSSRPREPSPAREGRRHHKSRRYRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C113</accession>
    <name>A0A2T4C113_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_20392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C113"/>
    <dbReference type="STRING" id="983965.A0A2T4C113"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="4">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="400" mass="43819" checksum="6128E2DCF5A6E980" modified="2018-07-18" version="1">MRNLDALLWGAVAERDDAACRNKLLGAAFVVTNRDGVVYSGSAGRVAFATDSPEFDVDTLTYGASLTKLLSATCLMQLMEQGKMRLDDDVRRIVPELRDMQILRGFTPEGKPILEDNDRPITLKHLMAHTAGLRYDVSDPALRRWSKYVGRPVGETIRLSKDGFNTPLLMRPGDGWMYGPALDWAGVALETVTGQTLGAYMKQHLLDPLGMEDTGFRANKLPHTAGRRAQVTRRDVDGGGGLSGFEPAPVEPELDSAGAGIHTTAHDYALMLRAMLQAEPWVLSGKAAREMFKPQLDERQRASMEEFLYAPDKRGPFIPGIPDGIGLQYGLGGLLALGDVEGQRRRGSLSWAGAGNSRWWIDPQTGIAAVLMVAVFPFGDEVACRLYTELERAVYAELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1S2</accession>
    <name>A0A2T4C1S2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1377919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1S2"/>
    <dbReference type="STRING" id="983965.A0A2T4C1S2"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="122" mass="12663" checksum="5C19DDCF6BEB4CD2" modified="2018-07-18" version="1">MPIGHVLLHVAKADFAPTVAFYTTVLKTLGLQKLPGFPEGMVGFGTAGPEFVLLSGEKTSNAHVAFQAADTSTVNAIHSSALENGAKDNGAPGIRAGIHPKYYATFFHDPVGNNIEAGTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2A8</accession>
    <name>A0A2T4C2A8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1259359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2A8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="142" mass="16177" checksum="8D6F878DEA41C407" modified="2018-07-18" version="1">MVGPINSSARFFSRPLRLGFLLFSLFSSVLAFTTCFLYVLHRSVHRPCKAYECDGWSIVWHLNSTLGLPTITAAFGQASHLAVSMLLFLPSSHVPWRSRFSLDRHGHANYGSFFVLSLFVFYKRSERGSFQEMGQKDMAIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2P7</accession>
    <name>A0A2T4C2P7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1335211</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2P7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2P7"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48" evidence="15">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="327"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="609"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="822" mass="88785" checksum="20160AF32D6F6B6F" modified="2018-07-18" version="1">MGLPGGNPRMPPPGDRSYQSYGGAPQQGGYGGAPHGGYGGAPQGGHGGPQGAGQRYNEKPSGGSGRVVQLQVEKVADKTLQSRLIYGNTCAVSPEDFPPRPDGTDYYILLRAGQPPGEFVVTATPVPGFPRGCISLSDPQRTWCGVAMRDTFTGEVYDPFASGGKAYLGSLDLEIGFASPTKRTETPYDEDELSKLFINNFQNQILAPGQRILMDVRNIPLLIVVKTVGLVDLSMADDGGKQIHRESHARGILTNQTRILFHRDGKGDFNLKPSATKPNSNAILAPDFKFEDMGIGGLGDEFSTIFRRAFASRVFPPGLVAKMGIPHVKGMLLYGPPGTGKTLIARQIGKMLNARPPKVINGPEVLNKYVGQSEENIRKLFADAEKEYKEKGDESSLHIIIFDELDAVCKQRGSGAGGGTGVGDSVVNQLLSKLDGVDQLNNILLIGMTNRKDMIDDALLRPGRLEVHLEISLPDEAGRLEILKIHTSKMSSNGLLDPSVDLAELAGLTKNFSGAEINGLVKAAASFAFSRHTEVGQLAAVKQDVANMRVNRDDFMNALTEVRPAYGVSEAELEDAVRLGIIPYGMHIESTIQEMMRVVGMIREDPNKFSTSVLFHGPKSSGKTALAAHIAVQSGFPFVKLVTPADLVGYRDEFAKKDYVHKAFADAYKSPASVLILDDFERLIGWNPIGPRFSNVMLEALTTLIVSKPPKGHRLLIFVTTSKASTLKLLEVEQDFAKKVAVPAISNLRELAVVLHESRVLNSEDVNQTISAIQQRTGRDSVAVGVKSILDCIFEARAGGPNSNVVETLTDLIVEKINEVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Q7</accession>
    <name>A0A2T4C2Q7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Q7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2Q7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="99" mass="10016" checksum="F696BAAB0F9E05C7" modified="2018-07-18" version="1" fragment="single">DGKANHSENKKDRDPEAEAEEKVEEEKLITAPEEEVPVAIESGFPAAGGDWDAPAPGFAGATPAVAAAGWDGAGAGAGADWAASGGQEWAADAPKDSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2V3</accession>
    <name>A0A2T4C2V3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S5, S7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1402426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2V3"/>
    <dbReference type="STRING" id="983965.A0A2T4C2V3"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="66"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="23563" checksum="CDAAECE48E6BC972" modified="2018-07-18" version="1">MSDGEIEIENSVVTDALPKDVVKEVGNVKLFNKWDYDVEVRDISLTDYISLRNPVYVTHSAGRYAVKRFRKANCPIIERLTNSLMMHGRNNGKKLMAVRIVAHAFEIIHLMTDQNPIQVAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQAIALLTTGAREAAFRNVKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C330</accession>
    <name>A0A2T4C330_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1334560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C330"/>
    <dbReference type="STRING" id="983965.A0A2T4C330"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB75981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116702" checksum="25FB13C678017771" modified="2018-07-18" version="1">MPLVTPEKLASLQKQSQDVRNICILAHVDHGKTSLTDALLATNGIISPKLAGKIRYLDSRPDEQTRGITMESSAISLYFSMLRRSAPDAAPEPKEYLINLIDSPGHIDFSSEVSTASRLCDGAVVLVDAVEGVCSQTVTVLRQSWIEKLKPLLVINKIDRLITELKMTPQEAYVHLSKLLEQVNAVLGSFFQGERMEEDLNWRVKMEERVNASAASKASVSDTTSDVGELQFEELDDEDLYFAPEKNNVIFSSAIDGWAFTCRQFASLYEKKLGIKRGIMERCLWGNYYLDPKTKKVLGQKHLKGRNLKPMFVQLVLEPVWTVYRATIGADVDGGKGDPTLLEKVTKSLNVTIAPHILRARDPRLLLTTIFASWLPLSTALLVSVIESLPSPPVAQAERLPSVIDESPDSSFVDSSIRDAIVSFKTDKSDPVVAYVSKMVSVPESELPENKRSTGQMSGEEARALARQKRAAAAALAAANNSQDEVVGLTDALGAVDLDDAKPAADGEKVDPEHLIGFARIFSGTLSVGDTLYVIPPKWSPANPHADPEPQQITVKSLYMFMGRSLEALNSVPAGVVFGIGGLEGKILKSGTLCSKLEGAVNLAGISLAGKPIVRVALEPVNPADLDKMIQGLHLLVQSDPCAEYEQFSSGEHVLLTAGELHLERCLLDLKERFARCDIQAGAPIVPYRETIVKAEEMRPPANKELGRGTVVTSTSSKQVNMTIRVQPLPANVTEFLLKNGDAIKRLHNVRKAVEEARAEENGEAIEADTELTAATAISAEELKTQLQKELETGKGREVWKGVVDRIAAFGPRRTGPNLLIDATKEGILPKIFAAAKASGAASAESAEKLHPSHLSDKLTYAFQLGTAQGPLCNEPMQGVAVFVEDVSLSSSEDDTSAREKLGRLTGEVIKAFQSSMRAGFLDWSPRLMLAMYTLEIQTSTEVLGRVYDVLTRRRGRVVAEEMKEGTPFFTIQAMLPVAESFGFADEMRKRTSGAAQPQLIFAGFEILDEDPFWVPFTEDDLEDLGELADKENVAKRYMDGVRKKKGLLVEGRTVARDAEKQKTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3N7</accession>
    <name>A0A2T4C3N7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1438915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3N7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3N7"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="111"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="413" mass="44844" checksum="2F95273DB4E543FE" modified="2018-07-18" version="1">MASSTTNAGQDEALPIVNLKPLLTKLWPTDTIVTPDEIADAISHFFTNQVSDAQTASLLMALHFTKLDFKADVLERCAYVMRKAAAPIPVEELQSVIQARGRKEGTYTGGLCDIVGTGGDNHDTFNVSTTSSILASSLLLVSKHGNKASTSKSGSADMVNCMKPRPPIISAVKPETLVKVYSNTNYSFLFAPVFHTGMRYVAPIRKQLPWRTIFNNLGPLANPVEDVLEARVIGVGRRDLGPAFAEALRVAKCRKALIVCGEEELDEISCAGNTLCWMLKEKSPGGEVVVEHFKVHPNDFGVSTHALSDVSSGKEPEENAEILCRILKNELPLDDPVVEFVLINTAALLVTSGICEADSSDMGHGDDGNVIKERGPGGQRWKEGVRRAKWAITSGEAWRQWQAFVDVTNEIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Q8</accession>
    <name>A0A2T4C3Q8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1333443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Q8"/>
    <dbReference type="STRING" id="983965.A0A2T4C3Q8"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000141">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="367" mass="39942" checksum="5DF12F5EEBFC9CE2" modified="2018-07-18" version="1">MFPPPSGTPTMNGNVNGNVNGNANANGKPAVFQEDLNNVLMCPDCKEYPPDLIEEFSSGDMVCNSCGVVVGTRIIDTRSEWRTFANDDQGGDDPSRVGGPQDEFVEGQHLATTVAFSESKAHKALSRTQNNANQDKAQKGLMQAYKEIVALCETIHMGANVSNAAKHIFKLVDKHKFMKGKPQEAVIAGCIFIACRQNNVPRTFREIFNLTSVSKKEVGRVFKQLQNFLQKIQDTEGEGATGLNTVTNYENTSVGAEDLCGRYVSQLGFKNQQKISKISRDLAEQATDISALAGRSPLSVAAACIYMACHLMGEPRPSAPIAKQTGVSDGTVKTAYKFLFAVRDQLIKKEWLEEGGKMENIPQVQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3R8</accession>
    <name>A0A2T4C3R8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1247508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3R8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="117"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="652" mass="69362" checksum="7D419F6391B980C9" modified="2018-07-18" version="1">MPSLAQDFDKEAGMEKRRDDGDAKSSSSLTIRSRSGDDGDGDDEKDVKRTDNKRAAVATSRRVSSSETEDGGDEGRRHERGADGVDGGDGDGSGSADDKDDGDEHALTLSRGRCIALVATVTGAAFLNTLSLQSVVIILPTIGHHLSVPDSRQQWIVSSYSLTFGCFLLFWGRIADLYGKRLIFILGSIWVTAVTAANPFVPNEIGFNVFRALHGLGAAANVPTAIGILGVTFPPGKAKNYAFSTYGAGAPLGSVFGNMLAGLMAQYTDWKWIFGVLAIMGGVISVCGILFIPPPPPSPSGTNKKGPPKIDWIGATLITVGLLALMFALTEGNVVGWDTPWIPVLIVVSILIIAAFAVWQWYLERRLTAASQTTTDAAGVLESGDTTASSSHAHRTLQPTPSPTPPLIKVSIFRNLQFSAVMIIMLLFFAAFNNYLIFTTYFFQEFQGLSPLQTMLRFIPTGVGGATVAVIVSQLLDRVPTLFILITGHVALCVACLLYAVPISPSTSYFAYGLPAMILAVIGSDTTWPCLTLFTSRALPREDQAVGGALINSVGQFGRSIGLAISTAVQTAVMADARGLPVKNAGGIVAWDSDSLRGLRAASWMNFAFGIVSMGVVLVAFRTLDVVGRVEPVSKKATEGVFRGQREEREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3T0</accession>
    <name>A0A2T4C3T0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3T0"/>
    <dbReference type="STRING" id="983965.A0A2T4C3T0"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="445" mass="48609" checksum="A94C4385626491CC" modified="2018-07-18" version="1">MSQLRALARLSRPGSSPAQWLKRAHSMRRYSAAAVSANPLPLEGYRVLDMTRVLAGPYCTQILGDLGAEVIKIEHPTRGDDTRAWGPPYAKYKPNSGREGPGESAYFLGVNRNKRSLGLSFQHPQGVDILHKLAAKCDILVENYLPGTLAKYQMDYESLRKINPGLIYASITGYGQTGPYSNRAGYDVMVEAEFGLMHITGSRDGPPVKVGVAVTDLTTGLYTSNSIMAALLSRAKTGKGQHIDVALSDCQTATLANIASSALISGKKDSGRWGTAHPSIVPYRAFKTKDGDILFGGGNDRLFGILCDGIGKAHWKDDVKYKTNADRVAHRDELEAEIEAITQQRTTQEWLDVFEGSGMPYAAINDIQGTLNHSHTKAREMVVEIDHEYCGPIKMVNTPVKWSETQPRVRSPPPVLGQHTDEILSEHLGLSGEDIAALKDRGVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3U2</accession>
    <name>A0A2T4C3U2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1457051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3U2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="20709" checksum="959C2E1601CD13F5" modified="2018-07-18" version="1">MAHNMDKDIYATVNSFYGLNRNPECSMADLVAMNAPIVRYIAAEAQASRRLVFEVAAVEQEAIQHLIIEYVGLAFYCTGTELEAMMEEMQGQGSASDVDDKIRAMMDAELSRWKEDPDMAPGLEDVFIHRWIVGKLYGSDGVETDNSFGDGPNGGTDQALDGVQQEEDESKEKGEKEETEEEVVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C438</accession>
    <name>A0A2T4C438_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1377260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C438"/>
    <dbReference type="OrthoDB" id="3647246at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057559">
        <property type="entry name" value="SAM_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23395">
        <property type="entry name" value="SAM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7102" evidence="2">
        <location>
            <begin position="633"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-like" evidence="3">
        <location>
            <begin position="809"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="882" mass="98089" checksum="3E55A1E57DD67A2D" modified="2018-07-18" version="1">MTQPLGKPIERIETADEYGRREKCFTNHRRHPFTFSSHIPGIKSTKQDVEKDGLVAQQGLRTAALPNPQSTEDILDQDQCHSEHLERFLQESPLEPSLAFSSNAFKDLYVPVDELDLGSCPEKDLQEYLQEVRTRRNRNPSEEWLPLIHTRTVRDEGLSFPPEMNRLWAQLNGELEVDKPVLSDAAAELVGELSKSLSRLACKELSTQQTKIRPFQYSCVDFVSPPLSPVSDDAEPFVPDGDVAVIDLSSDPSTPGRSAIEAIERDLDSDPVVSSTFMTSPSTGDLPGLIQTSHSVAQEAKVEAPVVQFSSDAPSERNALADIRLPLIGDADETAINLLEEKGQFEDAFETLLEDRRYYANQLVNQERFHPVDSMCRIPAPLLNFDIPPPEWAIGHLTAKMHFTFLRRSISGPFELPQMPRDPRSEITLRWAFLPTQKGSTALKDELSISDNLLAKYLSAEETPHLSSRDFVSVQQGLQVFRLQDEEEIEETSLEDDEADEEPPTNTQEAQSLTAMSSVHDNVPNNPESRLSTNLNPPVRRKLDDDALRLLPKLYDTSATSILLHNFMELRGIKRPRLNTQPPAASQPRGVLSSKLAKGPPDGNNPEAILSEVTEQMPPAPAPQFELPSEKASIIISVDLPRQILRRIESSWTPEKLIDVDHSRHNIQNWRPGASRPEEVTSPLSFEADISLSPSTGIITTNILKVRQRPLPGSQLLPPLRERIQKVSQKYETLIVLVSESNPQGEVMATLAPSDTAAYADFVSFAMALGGDVNVQFVPGATDTMGSWVLAYLCRQSSQCVALSRFLSSEETPWELLLRRAGMNVFAAKVLSRTLFEQAGQSGLAAFLNMPGRERVTRYGALLGGEKLLLMTGKILDRTWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C456</accession>
    <name>A0A2T4C456_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1463074</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C456"/>
    <dbReference type="STRING" id="983965.A0A2T4C456"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="332"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="492"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="576"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB76341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="740" mass="81200" checksum="375FC30894C7F5B8" modified="2018-07-18" version="1">MADSHRHAEEPNGPLDPELLYTKEYCIGGGSFGKVYKGVDKRSGRSVAIKIIDVENAEDEVEDIIQEIAILSELQSPYVTKYYGSYAKGAELWIVMEFCAGGSCADLMKPGIMGEDYIAIIIRELLMGLDYLHTDKKLHRDIKAANVLLGANGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADIWSLGITALELANGEPPYADIHPMKVLFLIPKNPPPRLEGNFTKAFKDFVELCLQRDPKERPTARDLLRHPFIRKAKKTTYLTELIERHSRWAATHKTDEEETWETHDSVPPQRARVNEDMWDFGTVRLVNDRGNLVNRPPMLNPLGASATNTRAARTSDDYGERRREPSNPTKLREHALQPSDTLKATNPSSAGTSRQSSPQRKNVPTPAQQQRTPTQQQRGFTPRGGPPPPSPVVIKTTSWEIHETTPRASKIVTVPALSQPPEPPSPDYDRELQAHLQRDMGILNLNIDLPDPVPTPSPPPPAAPAHRNISIPPGFEKPLPPAHGVSQRSTSSNKGSRYDLAEIPPFKPAPQPQTTVQRTVAPVVPLPPVTRVPATPTSSAAPPVTVTAPPPAPPSAPSSAPVPAPNASSSSLRSLGHSPGALETFPSPPAANPNGELDALNDVIFPALEEALKRRQIRLQHVYKPVPSGSTMSSKQQRAEAAHEKVRKLVYKLAHVCKEIDYHDKAEPVGMGREVGNFLEGLLEEILVRVEPLDEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4A3</accession>
    <name>A0A2T4C4A3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1333582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4A3"/>
    <dbReference type="STRING" id="983965.A0A2T4C4A3"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="24308" checksum="0735C4F595A048E2" modified="2018-07-18" version="1">MSAFWQDPNWVLSFRHTTLEKHIETTAKRYPRRLISDRATSRHQKAIDTQTGQLVGYARWILPESYATTADGEPIWPEALGPLVGKEEEEEIRRIADATPLNASNETDPLDNKVTEIKEELMKKKPYLCLDYLAVHPENQGKGIATLLVQSGMKEAEKLGLDIFVLACRAAWGVYSRLGFRVERELIQDDSMYGGDGNYGVRYMIYEQPAKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4L4</accession>
    <name>A0A2T4C4L4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1391986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4L4"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="107"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="496" mass="52780" checksum="4A1E34F00E458972" modified="2018-07-18" version="1">MEAILLRNLVEIQSRPPPDEATRPLTAPEKTYQRTHAVGGPFQEEPTHARPTTSRVNSFASDAVAAPSRTEDTDLERSRPASPVPDGDVDIVEVVPSAWEPYMNRFRLLSVCLANFGNALSDSSAGALIPYMEKHYNIGYAVVSLIFVGQALGFVFAAVLLDTLRARLGRARLLGIGQLLMACAYVPLVAAAPFGVVVAAFFFVGFGIAINVAMGNIFCGSLRNSTVMLGMLHGSYGIGGTSGPLIATALVTVAHASWNHYYILTLGIGFLTMALSVWAFWRFEREQSPAARERESAPDNSAVLGMLAAVRLRIVLLGSTFIFAYQGAEVSISGWVISFLINSRGGDPSSVGYVSAGFWAGITLGRFFLSAPAQRLGEKAFVYGLVAGALAFQILVWFVPNVVGDAVAVAIVGLLLGPIYPCSAAVFMRGLSHRDTLSGMGAISAFGSLGGAVAPFVTGLLAQAVGTWVLHPIVITLFVVMLLCWYGIPAETKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4U6</accession>
    <name>A0A2T4C4U6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1402006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4U6"/>
    <dbReference type="OrthoDB" id="5100278at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="67" mass="7546" checksum="C8D38F631D32AF10" modified="2018-07-18" version="1">MALQSVQVRPHETADVNELETFIESLINQTVPSTFSKVPVFSFKTTEENVKLIKEKFGDHVIIDIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Z8</accession>
    <name>A0A2T4C4Z8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1231088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Z8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="233" mass="25678" checksum="9BF7A9A613804680" modified="2018-07-18" version="1">MIHADEPGPSSMLYIAAIVLAQVDGELHTLAGGVVVTSSPSHPDSLRSHALLDDMLAKPCNPIKQIIISLLHQTPTETRLNRRPSYTSRQKKRGRLPLFLFPSSSSSPPCPVHSTPCPATSSARVLNPHPCIRSKLETPPSAPRLQPFAFILFSARSIENTIPPASCSSIFNYTRLSASLCNFVCFTLVLFYMYLPVLMLQMYHHHHTHTPPSDLFRRHLCSPLSSCSLSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C516</accession>
    <name>A0A2T4C516_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1231447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C516"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="9434" checksum="422865CC1FBEA374" modified="2018-07-18" version="1">MGTCLYLARGCVAVITDITGLGWAGMGEAKLLMVRWMYFYNDLFFFIFFHLVCLGGARRDEGWAVCGRGMVRFCALSDACEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C523</accession>
    <name>A0A2T4C523_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_299314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C523"/>
    <dbReference type="OrthoDB" id="4897741at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="10751" checksum="5D46B0475EA76236" modified="2018-07-18" version="1">MSVLLWDASGFFAFLSFPGSAFLVNTISWISLALGLFFSVPFVLCVIFDIVLWIWRTYCISAQEAQMPAIADTMTTSIDTKTATPSSEHHDLRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Y4</accession>
    <name>A0A2T4C5Y4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1376408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Y4"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Y4"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="344" mass="37651" checksum="C3725DA825F19E71" modified="2018-07-18" version="1">MAPAKLPTKPLGRNGPLVTRLGFGAMGLSVSYGHGGSDEERFKVLDRAHELGNTFWDTADVYGDNEELIGKWFKRTGKRDDIFLATKCGGHLDAAGNFSVRSDPEYVRQACASSLQKLGVSHIDLFYLHRLDKVTPVEHTVEALVELKEQGKIRHLGLCEVSAATLRRAHAVHPITAVQVEYSPFAIDIEKPEIDLLRTARELGVAIVAYSPLGRGMLTGQIKSPDDFADDDFRKTLPRFSKENFPKNLALADKIGSIAAGKGVTPGQLTLAWLLAQGDDIFPIPGTKKVKYLEENLGAINVTLTKEENAEIRKAIDETEVTGGRYSDAMAGHLFADTPELETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6G1</accession>
    <name>A0A2T4C6G1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1374080</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6G1"/>
    <dbReference type="STRING" id="983965.A0A2T4C6G1"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB77159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="572" mass="65043" checksum="340EE7E079555C84" modified="2018-07-18" version="1">MATAVSHRQPAEAAGGTKVLPLMTRDEIEDLIARGRQIIIHRGYVLKLDGWLQYHPGGDKAIMHLVGRDATDWVEVIHSAEAKEKMPRYRIGRIEGSWLNFRPPIQGGVFRTMEEIESDRRKGINAISTGEDNSSSSSRAPSPVFDVDTSELRDRKSASGHGAARSESVSSASTADKVPLDGMSYLDIVTREYIQLDLEKYPAVDEATQAHIVAKYRELHQKIIDAGLYKTNYAAYGWECFRYISLFVSMLITLRYGYYVISALCLGFLWHQLVFSAHDAGHMGITHNYHIDTFIGIFIADFVGGLSLGWWKHNHNVHHIVTNAPEHDPDIEHMPLFAVSHRLLGSLRSTFYDRVMEYDAVAKVLLRIQPWTYYPFLALGRFNLYVLSWDFIINSRGPRKGQAASHRWLELVGQVFFWSWFGYGILYKSIPDNWSRFVFVMVSHIASSPLHVQIVLSHFAMSTADLGPQESFPQLMLRTTMDVDCPRWLDFIHGGLQFQAIHHLFPRLPRHNFRDAQKLVIEFCKEVGIPYAYYGFSTANGQVIGRLAEVARQAAIFSKCQETITKSKDFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6T9</accession>
    <name>A0A2T4C6T9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1421043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6T9"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31515" checksum="8FC42EF142BE8387" modified="2018-07-18" version="1">MDNPVAANVLGTAGAVCWSVQLIPQIIINYRRHDTTGLQPSMMMLWACAGVPLGVYNITKNFNIALRIQPQILTFLSLVTWAQCRYYDKKWPVSRCLLVATPIALLMGAIQASLIFALRAAHSSHLTWPDTLMAVLSAALLAAGVLRHYWDIYTHRSVRGISFIFVGIDAGGDLFSLISVFFQPKLDILGMVIYGTELALWIGVFACGGYFNLLPWIKQHLKTPGEPNGSRGVSEASGDSDFQSPHAVSLRNIPSSTSVFRTPSSELAAARARTGFQDTEDVSVTVSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7E6</accession>
    <name>A0A2T4C7E6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_281136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7E6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="83" mass="9488" checksum="BFA4024BFE91C57D" modified="2018-07-18" version="1">MSYGSGSPRFSSMLTMRVACMQYVGRMQKGKGWWMRLTLHARVCVCVCVIYGMLSPVEACKTVRLLQRRFSHRQCAFCFAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7P1</accession>
    <name>A0A2T4C7P1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_285228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7P1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="92" mass="10794" checksum="68C59E5E9C8703D2" modified="2018-07-18" version="1">MNAHGLLQYVVSWKKKQKKKQKGDVCLDMTCRLLHRLNDKGRSWLQLADCCLFSFHSFFFFFFVYVSRGSGGTFTMTAMNYRIYNDSDELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8G3</accession>
    <name>A0A2T4C8G3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1354270</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8G3"/>
    <dbReference type="STRING" id="983965.A0A2T4C8G3"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="405"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="97"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB77835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="770" mass="88784" checksum="0C5238BED9021E39" modified="2018-07-18" version="1">MSDTDIPRAHRHRSARGESSRRDRERIRDRERDRERTRDRDKDRDRDRDRERDRSRKHEPRTRRGASSADEGRADNRRSRSQSQTLSAGALAQLNKDYVKQQRQAERERRRRERERTSGHEERERERAERQQRRERERERERQRERERERERERVRHPGPERIRVRERSPSPDPDAEPSIVPREYRKPGKQKKSRVVSGAAMEEGRTRGWGFGFGSGHARDDSYDSLRKEDLYSQPEKNKTKMSRRKKWIIGGICALVLLIIIIVAAVVGSKKKSGGSGDSPSSPASNSDVPTKWINTYLDPTTWASTEDFNTTFTDEMVGDLPIMGLYSDWDDSAQANDNVPPLNKPWGDYTKKPARGVNLGGWLSIEPFITPSLFNYPLSAGIVDEWTLCAHLGAKAAETIENHYNTFVDESTFKDIADAGLDHVRIPFSYWAVKVYDGDQYIYRTSWRYLLRGIEWARKYGLRVNLDLHGLPGSQNGWNHSGRQGQINWLNGTNGDLNAQRSLDIHNSLSQFFSQKRYQNIITHYGLANEPKMTYLDHDKVINWTETAFKLVRKNGYKGLVIFGDGFMGLNNWQGLMQGYDGLVLDVHQYVIFNVNQIDFTHQKKVQYACAGWTEQAEQSQDTKTGYGPTQFAEWSQADTDCAQYVTNVGQGSRWEGTLTGNASTAVLSPGCPTKNSQCSCDQANADPSKWSAEYKKFLSMFAEAQMYSFEKGLGWWYWTWKTESSPQWSYQAGMQAGVLPKKAYDRDFNCDVEVPDFSKEGLPEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8N9</accession>
    <name>A0A2T4C8N9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase LAE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1330784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8N9"/>
    <dbReference type="STRING" id="983965.A0A2T4C8N9"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="332" mass="38197" checksum="DF9894A30A109FC3" modified="2018-07-18" version="1">MSRNAPNGCVPPSQATAPPSPATSLRLTVGEPVSEPATASGERVLQDGFWEHGRFYGSWKPGKYLFPIDKEELNRLDVFHKYFLVARDESVTSTPLRKDGQPKIMDLGTGTGIWAFSVVEDYAKDAEIMAVDLNQIQPALIPRGVTTKQFDIEELSWEPLLRDCELIHMRLLYGSIRDDKWPHVYRKVFEHLAPGIGYIEQLEIDWMPRWENDQVPTHSALREWAQLFQRAMHRYHRSVTVSGEATRRKMEAAGFTDFSETTIRCYVNPWSPDRHQRECARWFNLAFSLGLEAMSMMPMSDKLGMTKEDIVDLCSRAKKEMCILRYRAYCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9B3</accession>
    <name>A0A2T4C9B3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1399335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9B3"/>
    <dbReference type="STRING" id="983965.A0A2T4C9B3"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="211" mass="23518" checksum="73B6ADA79BD5182D" modified="2018-07-18" version="1">MDHRPQAWGRPRDDVYGAYDRSYMQDNGPKQNTQQPIVTGTSVVAIKFKDGVVMAADNLASYGSLARFTDVKRLRPFAGTSVVGFSGDISDMQYLDRHLIDLSLSEAYESPDKPPYSAPSLATGFGAMLAQPIMRRYVPDEESAKKLSRDEAVNIVKEAMKVLFYRDARSLDSYSLAVVTKDGVELKENEKLEDQSWAFADRIKGYGTQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9D5</accession>
    <name>A0A2T4C9D5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1351313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9D5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9D5"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="470" mass="51734" checksum="24C5353FAE59018F" modified="2018-07-18" version="1" fragment="single">MAAPRELQPPEVEILVHVTAPSRTADDVAYRQLAQSYLSFQPRHRLPITADLAEQYLPSDTQPAGQPGDPHTQEQQQQQSTAASSIRQFAAPSRQPWVPESQDLSFRSVCDNRFSPPLPERLNPTDKAQPNQEDDGESLSTQLASSWHAPPSQISDSYPLPDAELRHATPTRVLEHWMKKPGTTLRKHAATPDHAHGGDIHIPSSVPIPLNLGGDGSHSLGQDKVADIIPVTPGEPQEASTRKRDAFSPTVIDETIYISNGAHDEDAVSEAASLRAESAPPLSKRQRGLIEEAASTHLQRSSSDAGPTLHTRSPSSHPAVSSKSLDTLEIRPPSPPAGIVDLEPADLIPDKLAKLAQDLSSRYRPVPRRELEPLERGYWLVDCSGWSDDVFREGWLFLGNYLRSGLAGWGVWCRRDEARRWIRLYCWAHVAKHAYLLLYLASGRQMKGTGAKWIGADGEVAVEVLPVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9F4</accession>
    <name>A0A2T4C9F4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1389917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9F4"/>
    <dbReference type="STRING" id="983965.A0A2T4C9F4"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="19196" checksum="6F4C158446D9A8D2" modified="2018-07-18" version="1">MFFLYNMERRVTLHPSYFGRNMHELVTSKLLKDVEGTCAGSYYIISIMDTFDISEGKILPGNGLAEFTVGYRAVVWRPFKGETVDAVVYSINPQGFFAQAGPLRLFVSAHLIPSDIKWDPNATPPQFTNNEDTVIEPGTHVRVKIIGTRTEVGEMWAIGSIKEDYLGCLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9G8</accession>
    <name>A0A2T4C9G8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_254748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9G8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="12902" checksum="C312480F13F0B9C8" modified="2018-07-18" version="1">MRPLSRVCLGYILITRATGSRIRSRRGHCLSISDTRHSITDSTTSLRNILSEVALLLLGFLVHSFPQCYLCGAHGSLFFYFFSAINVLFSYTIKGAIPYCVFDLWCTSNHQYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9R9</accession>
    <name>A0A2T4C9R9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1190026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9R9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18650" checksum="4558EF505F1238EE" modified="2018-07-18" version="1">MSPSNPLDGIDAHQSWSNATLFALMPKREKLISFVLLLLRRSLLLGGRAAIKLTMRGFRANDGQKGGAVLIRIRVHYMRDQAAQMLSMIRQRSLTGMPRGQKHMRGSATPHTTTLESNPRVDHWGLPLHPGRITRAINPTPMVRFKSLLRTKVSITMTAFWPSQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA34</accession>
    <name>A0A2T4CA34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1390091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA34"/>
    <dbReference type="STRING" id="983965.A0A2T4CA34"/>
    <dbReference type="OrthoDB" id="4900722at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015555115" evidence="2">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="375" mass="43493" checksum="9E34B4D615595B49" modified="2018-07-18" version="1">MRFLHLLASTAALASAAAVTDLNSNYNKPDDKKVDQFDKPAVDGPKVEGPKFVPIKPDDHRDQAANNNNKGADFHNGPENDRKVDGFKQDDHRGGFQQDDHKNGAQQDDRKNSAQQDDRKNAAQQDDRKNGFQQDDHRGGFQQDDHKDGAKQDDHRGGFQQDDHKNGVQQDDHRGGFKQDDHKDDHKDDFKKEGDHKDAYKPEPKKDEHKDENKWGGEHKDEHKDEHKGAYNPEPKKEEHKDEHKDEHKEQGHQWEAPKKEEEHKEEKPKWEAPKKEEEHKEEKPKWEAPKKEEEHKEEKPKWEAPKKEEEHKEAPKKEEEHKEEHKEEEHHWEAPKPEEHTVYTTVITTDYTTYCPTKAGIGALVIAGIAAMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAA3</accession>
    <name>A0A2T4CAA3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1194338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAA3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="99" mass="10962" checksum="6A9AC6AFC73F237A" modified="2018-07-18" version="1">MPAVVCMYSENRTWSLQALALGLSPCTCNDAFCPLQYQLRPTWPRMWRNRHVGDNRLSLACDATNPRLSDCFPCSAAARDASCPATTPQAHGKQGFIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAF0</accession>
    <name>A0A2T4CAF0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M440DRAFT_1399674</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CAF0"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1131"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1175"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1234"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="173"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1068"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="274"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="352"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="634"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="634"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <position position="745"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="789"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="823"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="852"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="933"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="934"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="935"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="1015"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="1021"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="1041"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="1044"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <position position="1045"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="1045"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PTB78530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1304" mass="144638" checksum="1E3C4D5D48EFB191" modified="2018-07-18" version="1">MPPSPTYQPPESPSNDSDSDLDLDIQELDPISTEPARELQQSHPAEEQRASRIALRNLRMGGLRRAKRDSGYGDLGRNRQDSHEQLHDLIEDHDEPSSRHNWSEDGGNGEDDAPLLGGQGSQSARPPTSRHLGSGLRWPRFLSSAKPGNMETEEQAEDDDPSSSRMVAVGSTQTSRFPTNIVSNAKYTAFTFLPVTLYNEFSFFFNMYFLLVALSQVIPALRIGYLSTYIAPLAFVLCITMGKEAYDDIDRRRRDNEANSEEYHVLQFTEPGMYSKSARPRRPLKSETVGRKPRKAQAGRHDLADIQEDEDQPTSVVQEISRKSKDLRVGDVLKLTKGQRVPADVVILQCHSTEGTTSSSSANEPAEEEEEETLLAFEEGESSSSAKGKAPEAPAAQSDTHSGPSGETFIRTDQLDGETDWKLRLASPLTQCIALEEFVRLRITAGKPDKKVNEFVGTVELMPTRQAAISQQPRPEGESSSDSNSAALSIDNTAWANTVIASQGTTFAVILYTGPQTRSALSTSPSRSKTGLLEYEINSLTKILCALTLALSIILVALQGFEKNGENAWYIKIMRFLVLFSTIVPISLRVNLDMGKSAYSRFIQRDPGIPGAVVRTSTIPEDLGRIEYLLSDKTGTLTQNDMEMKKIHVGTVSYANEAMDEVSSYVRQAFHIQPTTAPSSHGALVTPSSAMTNTVNVGATRTRREIGSRVRDVVLALALCHNVTPTSEVEDGKEVTSYQASSPDEIAIVRWTESVGLKLSYRDRKGMVLESTETGRPVVRVRILDVFPFTSEGKRMGIVVQFLESMHTTHPSLGSGEIWFYQKGADTVMSSIVAANDWLDEETANMAREGLRTLVVGRKKLSHQQYQEFASQYHEASLSITGRDAGMQRIVSRYLESDLELLGVTGVEDKLQKDVKPSLELLRNAGIKIWMLTGDKVETARCVAISSKLVARGQYIYTVAKLSRKDNAQEHLDFLRSKTDACLLIDGESLALFLTHFRIEFISIAVLLPTVVACRCSPTQKAEVAKLIREYTKKRVCCIGDGGNDVSMIQAADVGVGIVGKEGRQASLAADFSIEQFCHLVKLLVWHGRNSYKRSAKLAQFVIHRGLIIAVCQTMYSIALKFEPEGLYKNWLMVGYATVYTAAPVLSLVLDKDVDENLANLYPELYKELTSGRSLSYRTFFVWVLVSIYQGGMIQGLSQILTEVDSKRMVSVSYTVLVLNELLMVAIEITTWHPVMIMSIVGTFIFYIGSLPFLGDYFDLEFLITWGFVWRVLAIGAISLIPPYAGKLIRRTMKPPSYRKVQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAG6</accession>
    <name>A0A2T4CAG6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1399704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAG6"/>
    <dbReference type="STRING" id="983965.A0A2T4CAG6"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="301"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="583" mass="62801" checksum="D1C26202E71E3273" modified="2018-07-18" version="1">MRRHSLLLQPLTRTYRRVSGATSRIRPCELPPSSSCSRVACNRSLRPFTANAAQRDGFQQPNSGGGFGHGTNDTIYALSTAQGKAGIAVIRISGPSCLDIYRALCPSKALPKPRYAAVRSLLGPKAAGVDRGVLDSEAVVLYFPSPKTVTGEDVLELHIHGGTATIKAVLAAIPQCPSKHRIRYAEPGEFTKRAFLNDRLDLARVESLGDILSAETEQQRRAAVRGTSGRLARTYEGWREELLLARGEIEALIDFSEDQHFDESPADLLHNVADIVDNILRGIRLHERGGQRSELLRSGIRIALLGPPNVGKSSLMNLIVGREASIVSGEAGTTRDIVEASLDIGGYLCSFADTAGFRSSADLGPSSQVGAVEREGIRRARQKAQESDIVIVLASLESGPSGPAILYDQETLDIAAAAQARLIVVNKRDTVSSTELQRLLDEFRQRLGERMPELGSAHIAAISCKEASSLNSAGQHQDPGGIHALTEAMIGTFSQMTEMPVDLQDLLGVTARQAQLLARCRGFLEEFLAEARPEDEGVEADTVLAAEYLRYAADCLARITGKGEAGDVEDVLGVVFEKFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAJ9</accession>
    <name>A0A2T4CAJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1399732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CAJ9"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="288"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="458"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="508" mass="55952" checksum="BB1C2BE7418B399E" modified="2018-07-18" version="1">MPRPSPFLEPGDKTSAGTLAIISLSRDNFLPLTLEKSTGAVDGYLEGATLNTRFGSYPHSTLLDVPWGSQVRASNVDTGSRGKKRRRDATDEDTPIPSQDDDDDSTAANAPVKKAVTAPSGFIYVLRPTPELWTTSLPHRTQVVYTPDYSYILHRIRARPGTRIIEAGAGSGSFTHASVRAVYNGYPRDADDTKGKVFSFEFNESRYQKMQVEIEHHGLDGLVRLTHRNVYEDGFNVNGESPNATAVFLDLPAPWEALHHLSRRKVQKGGKEADDDDGSWVSPLDPKKSVYICTFSPCIEQVMRTVTELRTLGWVDVDMVEIANQKINISRERVGVNYPTEKGYNSSPADVAEAVTKLRTLAERNKETSRVQALQASADGVDSEMDVDSTPSRENPANLNGAAGDMEKPWMQGRLVHRPESELKTHTSYLVFAILPCEWDEEAEAAAMAKWPCGNEKKTIGNLDKQARKEEKRKMLEGKSKKQKKGGDTQAATSTVVVSATATPIDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAS4</accession>
    <name>A0A2T4CAS4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1328450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAS4"/>
    <dbReference type="OrthoDB" id="4900018at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="15773" checksum="7E8B1F08B1294756" modified="2018-07-18" version="1">MLFAGYFIRSTTPLPNPLFTIPHIFSRPPPPPSFPYIRSSFAAITNFFKDAFAIIQFFWPLFIIVFCISLSACFVQPYIFAFLSLGLRKVASFLRRVLLPFWQMIATAIYPVVAKLPSNWFPFGSKKQSGGKPRAGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAY1</accession>
    <name>A0A2T4CAY1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1327741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAY1"/>
    <dbReference type="STRING" id="983965.A0A2T4CAY1"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="521" mass="58808" checksum="C886E1758E5534EA" modified="2018-07-18" version="1">MSSLGGNTETCGLLKIPPEILDRITWHLTTPEYCRLRLTSKAVEQALFFKFTSEFFTRKQFMISEFSLKALRDISKSRLAGCLRHVHLALDQLDPLAVYGGTGPVAMKALHMLQLRLVEQDTLWTLGLVPKYLAEAFARLPNLETCVIRDFNSTRRSRDGPNCHWLSYGTNTLHKETGARPRPRHGNGWSGGGISENASRMFKAVLHGLAMAQARPTGIEVMERFGHFLFDSAFYIHPDFEAAVAPVLGRLKRLHICLDMAWSPLTRTSQTSESWHHANLAKLLRLCEDLEELRINGKRDYISNGGLTTLHHLFDWLATKPGTEASQPPVADEEAGPPIPPYAELARLKNLSLGMTSITVEDLVRLIARFADTLENLELWRIHLSLEDKTNDESLAENGTILYAVLLRKLLEMPNLNLRHIKLGNLHQTLRPIGKDAISGAVDFKPEASTRDKDVVEGHVSTTAVVEYTGSDWRHFVSHEMIPRLYTPRALCKDETDMDVDEDEDEDEDDDDAHNYWSNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAY9</accession>
    <name>A0A2T4CAY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome b560 subunit of succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1329694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="8">The heme is bound between the two transmembrane subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAY9"/>
    <dbReference type="STRING" id="983965.A0A2T4CAY9"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000178">
        <property type="entry name" value="SDH_cyt_b560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared with second transmembrane subunit</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000178-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="148" mass="16156" checksum="55171A2076D56804" modified="2018-07-18" version="1" fragment="single">RPITTQKLSPEEGQQVLASQRLNRPVSPHLGIYKMEQTWFGASAWTRITGCTLSGAAYVYFTAYLVSPLLGLHVESAALASGFAALPFVLKGAIKFSLAFPFTFHFINGIKHLIYDLGAGFQKKDILLGEKLLWISSFIGGGYLAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBU5</accession>
    <name>A0A2T4CBU5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1326013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBU5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBU5"/>
    <dbReference type="OrthoDB" id="5279542at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29002" checksum="707900B720A63481" modified="2018-07-18" version="1">MASQETPEMAQKMAQTTTTPVAPAPAHSLPQELAAAGYQPYYQPYPGQPTAAPAPVESAKGTYTRLGFHGVVVVLGAIGLGVSLSSLGADNGYGIGAAAAPGAGLCLAWSLAELITRAVRKWKSGIHPGAHVGICLILWLITAIMGGSLSAFVAMNDVSSRDEEDCIVYTHDQYGNARTYNECDDYYVQYPRGKALGGAVITCMLFAIEFGLFVDACVRTHRRNTAKARPVMVIAQPQNWGAATQGWQPMANDVQVPAAAARGQEPVKEYYAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBY7</accession>
    <name>A0A2T4CBY7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_228389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBY7"/>
    <dbReference type="STRING" id="983965.A0A2T4CBY7"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55308" checksum="8D912258B02B565E" modified="2018-07-18" version="1">MDGDEPASDGHPPPPPPTAKAKTGSHRQLPKESKDAYFRNLYTRAPDFKALARLDPDFAAVVKGRELNFNDPKSVMQLTKTLLKVDFDLQIELPEDRLCPPVANRHNYILWLKDLLDTTSYDEPGGKAVGLDIGTGASCIYPLLGCVQRPWSFIATGAFPCHSAVYRCLGVTAANSLKDIDEKSLEWARKNVKLNDLESRIQIISCNPDDALIPLDDIKLDSLDFTMTNPPFYESEEAMVKSAEEKSRPPFTACTGAKVEMVTQGGELGFIDRIFQESLVLRQRVRWYTAMVGFLSSLTRMVDKLREHKIDNYAVTEFRQGNKTRRWAIGWSFRPLRPALSVARGTKAALSKGILPPITEYVAFDMPLGGSIGIFAENVSSAVGALDLISWDWDREKLQGVGRAVDKVWARAWRRKRKREAEAAEQGIGEEKTTEQVCTFGFSVAVRVSREHVSVEARWLEGHDEVAFESFRGFLKTASEKAAEDMKKGADKASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCB1</accession>
    <name>A0A2T4CCB1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1349720</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCB1"/>
    <dbReference type="STRING" id="983965.A0A2T4CCB1"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="18">
        <location>
            <begin position="555"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1116"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="471"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="791"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="968"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1031"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1061"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1088"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1126"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB79203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1255" mass="135318" checksum="928018665BF85EA2" modified="2018-07-18" version="1">MVRLRDIPRTATFAWSPGAGKPMVVTGTKAGAVDADFSDESKLELWDLALDNQEQGIELQPVVSITTESRFYDIAWGPPDANHPRGIVAGALENGTLELWDVEKLEAGSDASISKTTKHTGAIKALQFNPLKPQILATAGAKGELFIYDIGDIENPFRLGNAAARSDDIDCLAWNRKVSHILATGGPGGFVTVWDLKTKKASLTLNNNRKAVSAIAWDPNNSTKLLTATPDDNTPVIFLWDLRNSNAPERTLQGHEQGVLSLSWCQQDPDLLLSSGKDNKTIVWNPHTGERYGELPEVTNWTFQTRFHPHNPNLSATASFDGKITIQTLQNTNPDKSQTINEKPLDDEEFFRAAQTQPQGASWSLPKAPKWFERPIGASFGFGGKLVIFKELPTQAGQKRQSKLSISQFSADSDVASAIERFQEALKSEDVVTLCEERKAQAQTDEEKADWTVIETLIGENPRSKIVEHLGFKEEDLTNGSSAGTPEGEEKETPKKEEEATDAEGKPRRLSNFFGGDGEGDGDDFLSGLAANKGAKTDKPFHLFSDGDTSVEKDITRALMLGNFTKATDICLKEDRIADAFLIANCGGQELVEKVQSAYLSRKDGVPSYLRLISSVVDKNLWDIVYNADLENWKETMAIICTFSDPTEFPDLCEALGDRINEQGQRKDASFCYLVGSKLEKVVAIWVDELKEAEQARMQQESGDSTFSVHTQSLQSFIEKVTVFRHVAKFQDKELSKTEDWKLATLYAKYTEYAEILAGQGKLEVAQKFLDLLPANYPAAELTRSRVKLATQKKPAAAPVTASRRTPSITSAGKQPPVVGYQPPQPASIPTPTNPYVGLQQASPAVSTSQQYRPPVNPYQPQGYQPQGYQPQGYQPPSQFGYAGSPVAPPPISGPPRNSTPSSGPPPAAKAKNAENWNDVPMVTKAAPRRSTPSVPPIASPFGAQQGQAAHPPPPSSTSPYGAGARASPPPPPKGPAPPRVQSPLAGPPVTGPPRTSSAAANQYAPPTPITGAIPSHPAPPVMPRTASPYNAPPAGPPPSNRYAPVTGAQQQPGQYGSATMPPPPGPASRPPPPANPYAPPVQQQPAAPSPYAPSPYAPAPGQVPASQPPPTGPPPMGRPPSTASAPPPAAQTAPPPAAKHPPGDRSHIPPHAQQLVDILSSDMQRVASKAPPTFAPQVKDTQKRLNILFDHLNNEELVQASTIEQLTQLAVAMQAKDYATAQRLQMEINRDKTEECGNWMVGVKRLISMSKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCE2</accession>
    <name>A0A2T4CCE2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1163468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCE2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="266" mass="27775" checksum="89D250648558F436" modified="2018-07-18" version="1">MAADEGRQRNRRGPGSRGSMQRGWTRVMVPGCSGRSAAGSGEARAANASTKGRLCRCSRARLQAAGIAAGQGGAAMELDGLVVAGRDAGGGAGADADAHEMQLQVVFGDRYQDRRQTVGGGGCTCWRWLLPKGWSGLELALLTALLGAPVPFVWVGTYLLSLHLEVAALQSRLTLASTVLKAEARLAVLDPRQLLRFPQFDAPGAFSGAFGRCQGGAMGALEALSAASTGVNPQWLLLALKAAILNNGRASQCPVRFQFILTLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE65</accession>
    <name>A0A2T4CE65_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1347331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE65"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="70398" checksum="73F7082FA230A0EC" modified="2018-07-18" version="1" fragment="single">MMGNPLAAAALNSLDRLVPADGLATCRCQTCLRLGLECVQFDIFCPINVITPTRDARSSRSASDADPEPDVDGSNHSSPASTSSGSSGGSAEDAESSTGRELVPMKARRLSRSSAQSQPELQFQTQFQLVHPGRRRRGTRDSQDRQAMALRAGGISHDIPSLSEFSYLSTSEYFYLQYYLERLSNVLVNANSRVNPLKSLILPRIASSSLLLDAICATAAVHRSSSSEVDRSEYTTMATRYYVRVLSAVRELIPRVSSSSSGPGSVSGRAIDLITDGDDLNLVDDRSEIGEDDASSSSKGKGKGKANNMRNRPIEDKDTAEMAILASIFLCKYEIIKDGVENWRLHLRGIESLCQSLDADQAASMSETLAYVRSFMSYHKNIARITEYSPQSVDEFEHEPFEQDRLFPVDPYMGFSQSLIILLGRVNDLLAIDVHKEPEKLEQGIRELLRLLALRSWDAHRFAIPEGMKPSTIENSSHIAEAYRCAVIACIHAVLELLAEREANGANSSSQSDPTSLDLSLQSESLSQLSMNWVYLHALLPMTKDDALTECLAAVARVPLGCPEEAGLLPLLFIVACETNRPAQAQEALQRVEALGSHIGLGNVKCASALLNQVWKRRSKQRNFSDWRGLLAKANWDLIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE69</accession>
    <name>A0A2T4CE69_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1326822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE69"/>
    <dbReference type="STRING" id="983965.A0A2T4CE69"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="134"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="301" mass="33837" checksum="B28530D8C59F3EDB" modified="2018-07-18" version="1">MSDLQQPLENLINTFNELNPSTVEELFSEPSPLVFMRYVARNTPFVIRGGASSWKATKKWDSAYLRTVLAGQSVNVAVTPFGNADAPTFSPQHNATVIAKPHEETQQFDDFFTYMIQQETDPAFPLDSEVRYAQTQNDNLRDEYLPLYPDAQRDIPFARIALGKEPDAINLWIGNSRSTTAMHKDNFENIFVQVVGRKHFVLLPPLLHACVNEDLVLPATYVRQDGGFALAVDPDSPLVPLATWDPDEPERNATPLSALARPLRVTLEPGDMLYLPAMWYHKVKQSCPDGGEGFVLAINYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF26</accession>
    <name>A0A2T4CF26_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras small GTPase RAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_46645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF26"/>
    <dbReference type="STRING" id="983965.A0A2T4CF26"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="22446" checksum="84719C04F46A1CB0" modified="2018-07-18" version="1">MAQAGVQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVIVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSVVSPPSYDNVAAKWLPEITHHSSGTPIILVGTKIDLRDDPATRAALTKQHMEPVKYENVLNYVKEVNKTNKIIYKYIECSALTQRNLKSVFDEAIRAVLNPTPQASKAKKSKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFB4</accession>
    <name>A0A2T4CFB4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pali-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1418847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFB4"/>
    <dbReference type="STRING" id="983965.A0A2T4CFB4"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015734710" evidence="7">
        <location>
            <begin position="26"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="695" mass="74011" checksum="B909173621B0ED66" modified="2018-07-18" version="1">MLRPATPLTVLLGIAFALLLLSVLSAPIISAIPLGSFQNVQFGVFGFCQPSGCSSVGIGYDIASILTDTKGSSFDLPSDVRHTLSSILILHPVAAFLTLVMLLMAVAAHFRAASHSSRYLLFFLVFNLVTLLVCAAAFVIDVLLFIPHMAWGTYIVLAATVLVFLSLLVSCAMRRTLVSRKDRKRRIAENAEMSGENYYNRENQAPKPSFTMSTQPTVPVVSGGNGTQDILPAFATYETPRDDQVSDERIPLTQRTTSERSPHGRQLAPADMAAAAGSDMGSAYSGPQRSASQDSYGNYGNMPPSAYGAAGQPYDGRSNRVPVRRETDPVNGYGAGGRGGYGAPMRGRGGYGPPGRGGYGPRGGGRGGYGPPPRAGYNGQYYHMPRGGGGRGPSPINNPIDGLAGQDNRMPSPSQQGYAGAPQLPLQSDVPMQPNPSGGAAGNTYVPYRPNIDLPRAESPPPLPEPTESAVSSVANAVEMDATPAAGANSNNAQFGNLRDSDTDVAGMVHLQQGQLPLSPRRDTFASDGSRYSQDEQFAPSRAQWNQEAGRNSPRVPVANSSRGPTPNMSGTTAPVVEAKGKGDYYEDVDPRFDQTVHTLPRRQTPPPPLQLNALDYEDIQGAASGTRSPAESEHSNFTSISQRGINPQWSPQPPMPQRRPVQQRHDMILDNPDFKLPGGRATAAGKRRGPGMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFN0</accession>
    <name>A0A2T4CFN0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1467631</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFN0"/>
    <dbReference type="STRING" id="983965.A0A2T4CFN0"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="243"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="683"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="828"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB80350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1180" mass="132693" checksum="B108549B8001085B" modified="2018-07-18" version="1">MRVIEVIIDGFKSYAVRTVISGWDESFNSITGLNGSGKSNILDAICFVLGITNMSTVRAQNLQDLIYKRGQAGVTKASVTIVFDNRDKKKSPIGFEEYATISVTRQIVLGGTSKYLINGHRAQQQTVQNLFQSVQLNINNPNFLIMQGRITKVLNMKPVEILAMIEEAAGTRMFEDRRDKALKTMAKKETKLQELSELLRDEIEPKLEKLRGEKRAFLDFQQTQNDLERLSRVVVAYDYTKCQEKLKQSAADLEAKKQRQKNLESSVARLRNEISNLEEDANKVRAQRDKELRKGGKAQDLEDKVKKHANELVRLTTVMDLKNSSLREEQEKKAGAERAVSELETALMEKTANFEDVKAKYEKAKDDLEKQSREAESKEELLQTLQTGVASREGQENGYQGQLQEAKNRATAAATIQEQARIKIAHLQSRVKEEEPRARKAKEQNAHLLRDLDGLKSQEQRLEKELSRFGLEPGQEEAMYKQESSLQQTVRSLRQECDFLKRKVANIDFTYSDPVPNFDRSKVKGLVAQLFTIDEGKAPAGTALEICAGGRLYNVVVDSEVTGTQLLQRGKLRKRVTIIPLNKIAAFKASAQTIATAQRIAPGKVDLALSLVGYDHEVASAMEYVFGNTLICADAETAKKVTFDPNVRMRSITLEGDSYDPSGTLSGGSSPNSSGVLVTLQKLNNLTHQLNETERSLKELQISIAREKSKLDQARQVQQELDLKRHEIKLAEDQIGGNSSSSIIQDVENMKATIAELQASISDAKARQTEANADIKRIEKDMKDFDNNKDAKLVELQKSLDKLRVSLERNSAAVKTLQKTLQGAQLDLEQVGGDLAAAREQLQEVEVNIKAQQRDVEDLAKQQAKVTESHAAVQAELDEERAKLHQFDDELRALEDATRSKNARITEEGLEMQKLGHQIEKFHKEQQSAAENVARLEAEYEWIHDEQEMFGRSGTPYDFQRQNIGECKATLRNLTERFQGMKKKINPKVMNMIDSVEKKEVSLKQMIKTVIRDKRKIEETIVSLDEYKKKALQETWEKVNGDFGQIFSELLPGGSFAKLDPPEGKTISEGLEVKVCLGKVWKQSLTELSGGQRSLVALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGRLIKTRFKGSQFIVVSLKDGMFQNANRIFRTRFSEGTSMVQALTPADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHA7</accession>
    <name>A0A2T4CHA7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1322688</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHA7"/>
    <dbReference type="STRING" id="983965.A0A2T4CHA7"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1059"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1110"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="14">
        <location>
            <begin position="405"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1195"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB80949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135624" checksum="01C38F8864B5C2C6" modified="2018-07-18" version="1">MSLPERPGASPSYDRRASYRSPPASRRARPMDIETGTYESSVPGHHSRGKSASSYAETISNSNVNTESMPLSPTEQHASSRTPDPTFTRKRSLIRPERNRIDKDHRNYHYHRHAANMNVLPSSTGNDPLLENLAGSTEQSANSESIADETPRPSRSRTASGDHEKSGAAVKTSQRRKSGKITKENSRRSSKRKSKPIEELRPPSFWNVYCAIVTFWCPDFILGCCKPTRAQRRAWREKMGLISIILAIMAVVGFLTFGFTAAVCSAPPVRLRVNEVSGGYMIFHGVAYDLSNSHHPVAEGIPLRQDGLGANVLFDLPQKHSGEDGSFLFQNVNGNCKGLITLAEGSDVPTDSSGDLAWYFPCTTFNQDGSSQPNLTIPYYLGYACHTSANARNAFYGDLRGTADVYFTWDDIKNSSRNLIAYSGSVLDLNLLNWFNESQVQIPDRFKELRDTNSDVNKAIRGRDVTRMFQSSADKKNMQCFEDIIKVGSIDTETVGCIASKVVLYCALILILSVVGARFALALIFQWFISRNYAAAKTSQSSDRRKRNRQIEDWSEDIYRAPVRLPGDGSTVVTSERSKRTSSFLPTTSRFSGVYGPDRSSSSRRFPTTMASQGGSSTLYPPTPMYKQSNDSRASFLRSDPYGSGPISEGPGPAGFIHEAVVPQPPSDWMPFGFPLAHTMCLVTAYSEGAEGIRTTLDSIATTDYPNSHKVIVVICDGIIKGAGETVSTPDVCLSMMKDLSIPRELVKPYSYVAVASGAKRHNMAKVYCGFYDYGSSSRIPADKQQRVPMITIVKCGTPDEEKASKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLWKVTGISPDYYEILLMVDADTKVFPDSLTHMVSAMVKDPDIMGLCGETKIANKRASWVSAIQVFEYFISHHLAKSFESVFGGVTCLPGCFCMYRIKAPKGGQNYWVPILANPDIVEHYSENVVETLHEKNLYLLGEDRYLTTLMLRTFPKRKQVFVPQAVCKTTVPDEFMVLLSQRRRWINSTIHNLMELVLVRDLCGTFCFSMQFVVFVELIGTLVLPAAIAFTFYVVITSIIHQPPQIIPLVLLGLILGLPGVLIIVTAHSWSYVVWMFIYLVSLPVWNFVLPAYAFWKFDDFSWGETRKTDGDKGKGGHDESKGEFDSSKITMKRWAEFEREKRAKSGYWGSRENVVGGSTNSWAMPPPGHHSEEYLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHC3</accession>
    <name>A0A2T4CHC3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_63096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHC3"/>
    <dbReference type="STRING" id="983965.A0A2T4CHC3"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="852" mass="95196" checksum="59C193DF23DE3FD7" modified="2018-07-18" version="1">MPKATETKTTKTAAQLKAAKDKEHPPPPPPEVIEPSSTDRPEGAVYHVGKLLGKGGFAICYSGQLQPSRHKFALKIVKSQMPSKMEQKFQTELQIHSKMRHRNIVQFFRAFSFVNCTFLVLELCPNGSLMDMVKRRKGLTEPEVRFYAVQIAGAIKYMHSKGIIHRDLKMGNIFLDQQMNAKIGDFGLAALVVTGRDMQTIRRTTLCGTPNYIAPEILEKGKKGHDHMVDIWSLGIIMFAMFTSKPPFQSSTTDEIYRRARERDYEWPSAEVSQKYISQEAKDLVATMLEDADQRPDPDAIVQHPFFTAGYMPSSPEITSKLREVPPDADEYYASRLSGSVMAQSLRNLQDQCRECGVGPWAAEKTSHTQIWKEMAAEEKAGLTPVIPLSDGVVYRPFDDWLREQHQIRAKYAASISSRSTSSEGQEDSTTSSQRMPPPTGLLRQPPQSFAAQQRTQGRPATSASTRTRTAPELGLSTSQSTRVRPRQERPESATREMPSSSREALDSTAAASTTSSSTARSMRMSARAQLSSTRSTPNLPITERAGAVSSSVPLHKRRNSESIRSATLFSPSESPMEMEGTKPDEILERLRGLQAELERALNARTMAIISAKTAPPPHPHIVVKWVDYTNKFGLGYILNDGSVGCILRDIPTTEGSKTALLPPAGVFIRGAEKHILRRQDESYPDRHQPVPMMEPIQFFENNGEAGLSQVTISPQQFRVSINEDGTASKMAPGKDVFQHRKRERIILWKKFANYMIAYGRDEIPAEEDEEESAMSPGRRGTPAELVTFYQRFGDVGCWVFCDGHLQFNFPDHTKIVLDATGTWCHFWHLPQEAAERLASTGSIDKTWSMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI74</accession>
    <name>A0A2T4CI74_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1323248</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI74"/>
    <dbReference type="STRING" id="983965.A0A2T4CI74"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB81259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="230" mass="25475" checksum="6A41DD3565DA0494" modified="2018-07-18" version="1">MPPSTTVAPQTPAPPSSPIKNAYLIVYNALSAIAWGLVLQSTVLTLFESGPSIVYLTTGEFTKWTQTAAAMEIIHSLFGIVRAPLLTTLMQVSSRFLLVWGVVHLYPHLAIESPTYSSMLIAWSVTEVIRYSYFALSLSGFTPRLLTWLRYNTFFILYPIGILSECSLVFLAAVGPAAAEKEYPLALAPYALYAILIIYVPGAYVLYTHMMAQRRKVMRSLKAKDVKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI97</accession>
    <name>A0A2T4CI97_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1012316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI97"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="223" mass="25631" checksum="C4BEF55B990BBCC1" modified="2018-07-18" version="1">MCCFVLVQRLVAPTDKIDLHTWPSGVCVSVTPEAVYVRQRRAVMFRFYETITIMDDGQDGSPRICSSRGQHDVRLRFGSFSGLGLMANDFLVRSRSRTLAVPHHHRHLRTCKNSRGCFYDQANHLSQRFRLKSSPPQGEVAMESWQLFWIDNFPGCAADPRISSFLFCKLRQWRNSNMLHRNWSLPPSRPGVKEGKRTDSLEVGADLSLSFYPILCRAAKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIB3</accession>
    <name>A0A2T4CIB3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1012366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIB3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="17647" checksum="A852FBCD521A8C34" modified="2018-07-18" version="1">MSIVHLHCHASCHTTLGAVNAGTCDAHCFFSCACAKSTYRRKQYYFLFIHSLLLPSPPSLVHSSARYQVPQSQAPLALAYSPASYYLFAPRTQRRRNDPITRPFSPQLNSTLAHQLIQLTQTLASVPRAAEPLRSHAMRCKCNAIPDASLKRRIWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIB7</accession>
    <name>A0A2T4CIB7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1367229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIB7"/>
    <dbReference type="STRING" id="983965.A0A2T4CIB7"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="297" mass="33211" checksum="B66CAA11809235F7" modified="2018-07-18" version="1">MRGKRSKQYRKLMEQFSMTFGFREPYQILVDAEMVKDANKCTMDLTARLQSTVHGKVKPLITQCEIRKLYAEKDQPGGNAAIELAKTFERRRCGHHPDEYPKPLETIECLRSVVDPKSTGENKHRYVVASQNVDVRRMLRGVRGVPLIYIKRSVMILEPMADQSVQIREREEKRKFRAELKKPVGKRKREEKDDGGDNGDHSESDDEEGERSKAGRAPTTEKKPKKHRGAKGANPLSVKKKKPQQAPKKETGGKPEAAASDAPAKRKRRRKNKSDSATAPGASEPAAAAPSNGGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIJ9</accession>
    <name>A0A2T4CIJ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1321854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CIJ9"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="313" mass="34455" checksum="8DF043D99C4851A0" modified="2018-07-18" version="1">MASHLTAQLIQQFRTNATLTRIRIAILDTGYDARSQFFTAAARKKRLIKWKDFVDGQEQPLDRDGHGSHALSILMKVAPAADICVARVAENTEDLQNRPSAIAQAIAWATNSDEADANIISMSFGYPEEPEVEGKSIISNAIHRAVHHRGGQVLFFAAAANDGGNQREMFPARHDKVISIRATDHQGAFQNFNPAADALETHVLGTLGTEVPGVWPSTQETEACKTGTSIATPIAAGIAAAILGYAQAGIALKRFGEDAHMERLWTKRGINLTLMKLSREMTGRHFYLYPHEFFREAKEQQRDALLLEAVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ41</accession>
    <name>A0A2T4CJ41_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1427438</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ41"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ41"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="311"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="525"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="12"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="679"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB81589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="720" mass="79957" checksum="36C33C50F713A9D8" modified="2018-07-18" version="1">MPLDIEEILRKKKAADAAAAKPRFIPKAERERLAAEKAKQEEEEKKRKAAEEEQKRRQEERKWDSVANGWSTSNGNGIAPPTGPRAMNPPNAGRGRDGPRDGGREGKKNSKTEAVKRSAADIEDELLRSRYLGPEVNQQSNFSAKKKRMRTTEKKFNFEWDADEDTSRDNDPLYASQSVNRGGSLAGLGGEFDKEAEQRARKRAKMIEERDPEHGRERAIGIMEDFYRARDRARERAERTGLGRHWSEKALSEMRERDWRIFKEDFGISTKGGAIPNPMRNWEESGLPRRLLDIVDRVGYKEPSAIQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISDLPPLTEANKNDGPYALIIAPTRELVQQIETEAKKFAEPLGFRCVSIVGGHSLEEQAFALRNGAEIIVATPGRLVDCIERRLLVLVQCCYIIMDEADRMIDLGFEDSVNKILDALPVSNEKPDTDDAENAQLMKRYVGGKDRYRQTMMYTATMPPQVEKIAKKYLRRPAIVTIGNAGEAVDTVEQRVEFVAGEDRRKKRLQEILSSGQFAPPIIVFVNIKRNCDAVARDIKAMGWSVVTLHGSKTQEQREAALASVRSGQTQVLVATDLAGRGIDVPDVSLVINFNMATNIESYTHRIGRTGRAGKSGVAITFLGNEDADVLYDLKQMLSKSSISKVPDELKRHEAAQSRPVRGGASRRDEAAAAEGGKGGGGKGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJQ9</accession>
    <name>A0A2T4CJQ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1459860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJQ9"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="212"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="717" mass="81701" checksum="C1008434F43A6658" modified="2018-07-18" version="1">MFDPADLELIRHIALTYELELVHASFNVMCRSQDLPLISGSLYDFEPRQIRLLATTLFNWLLSALPANSALGVSLNVLASSMMTSSDAVCCNATNRIILLIEAAIHATDTMLVWDLGDLQEIQGCTFLDVQEFFEKFFDAKDLTELAQDVYNLLKEQHVNNMWTFLRASPSMTEMMRWLDFLQDDILKVEHRRFWEVNLASELTEGIKGGRLDVCVKRKSEPRSPAMSGWEDLLAIGQLTAEEDIKKRLVELACYARHLFDFQATRRYLHAFTICGSMLEPWVFDRSGCYSPGAFDIHQHPERFIRVITGYIMMSEDVLGLDTFVQRKGRSGFIDIVGPEGEQKKLYLSPTLLDHRPTIVSLATSCFLAKHADSTDHDHVVKFSWPLYHQSSEVDVFKLAKQRGVQGIVSMVTHFEITTVNEMRRGMTFGRRYAFDDTASAMPTPSQPLLPSQPLSTKRSRSPDSSSSQSKKRKSTSTKEALHLRRPEGNTQLPGRQNDVAPKEDRRNAIKAHQSLYVQGKMLHQDISENNIIITDVKKTGFSGMLIDFDLVREIDKEPFKPGTRTGTKEFMAIRVLRGIEHTYRHDLESFFYVLLWQFIVRGWQFVGRRNPVAFSALNGWRAASSLEHLARNKQANMDKECFEAVLAEFPPEFQRIKPLCRTLRSILFPMKDGALFTGTPWHPDTLYLPILAAFDEIIARGRKGTEEARDEGQEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJW1</accession>
    <name>A0A2T4CJW1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1418446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJW1"/>
    <dbReference type="STRING" id="983965.A0A2T4CJW1"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="341" mass="37138" checksum="5CBC5936033AB9A5" modified="2018-07-18" version="1">MDRGAAQFSQSGLPSPYSSSFGDQHSEGSSAEHASAAQYPGKQDYPASVTPTSEYSVYPPSARSGSFSEQIQRSYHPSSTASSGDPSIAAPSPTYPYGQHSPYAPNPDMSHGYSHPSGGMYAQPRPDWAGYSQHGAPPLTPGHPVYAQSPASAPQQRPNQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGQKRTPEEFKEIRKEWKQRKKEEEAQRKAEEERQRAAAANAAQNGGGDPQAADGAPSSGYPGRAVQLPPIGYQPTQYPAPPSANVAQQPMPEYGASHMYSNYQPHSPYAQPSQQNLYSQSNGAPPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJX5</accession>
    <name>A0A2T4CJX5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_94783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJX5"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="81" mass="9456" checksum="390A6B8FDE7AA70B" modified="2018-07-18" version="1">MTDYLITIRMYADKALEKVSIGIEWLQTGLDLSSFPSQEVDAERKSLFVKDIIRYTPSRGCYTSQQPHYFIIASKIRQQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK13</accession>
    <name>A0A2T4CK13_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_95306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK13"/>
    <dbReference type="OrthoDB" id="4196148at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="65" mass="7584" checksum="26DCCE11222E2E14" modified="2018-07-18" version="1">MLDEKDLDLLVTCWTARLWKQAQKSLGSPPTGRSRVKRFAARFLRLRYMTDLVSSKSTPTRRLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP42</accession>
    <name>A0A2T4BP42_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1345092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679163">
        <property type="protein sequence ID" value="PTB71061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP42"/>
    <dbReference type="OrthoDB" id="411615at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="52" mass="6214" checksum="9CF04215AFA7DD42" modified="2018-07-18" version="1" fragment="single">VDYLKIFTFIVKLIIYKALFTITTALDFKLEQIDIKIAFFIRKLKRIFILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPD2</accession>
    <name>A0A2T4BPD2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPD2"/>
    <dbReference type="OrthoDB" id="4899962at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16568" checksum="62E86A98809D9C6C" modified="2018-07-18" version="1">MAIQRSAAEYFPPMSQPQDGNLSTSRRNNPQTLRRRQREDVSILRRNAIRRPSHARPVYIVINNIAIRTRTGRPQTPPALDGADELEPLEAQPAVVGLVESGTTADSPLAVQRRKLGIEVVAERPTTSESRPAHCTSSFRWYKHKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPG2</accession>
    <name>A0A2T4BPG2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPG2"/>
    <dbReference type="OrthoDB" id="4900241at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="217" mass="23127" checksum="EBAD53FBF2E46839" modified="2018-07-18" version="1">MSSLRSSSSTSTSSSSTLPSTAGGSHRSSKSGTWKAEYLPLSRDKGLSLRFIAYAAGASLPTTVKKMTRLEKKKNNNNNKEAQGGGGNIPRWDFFGRDTQLFWVVVPEDRQKKRGRSRTSRERTQQQRSRSGASSQGAAVMPEVNEDDNNIPPEISSSRGPLWTGGSTMGSVVPPQAGGAPVFGGQPKPVGFPFGIPPVVSLPGGSAMPRFGRKQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPS9</accession>
    <name>A0A2T4BPS9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1152095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPS9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="25340" checksum="C573B26604A560E0" modified="2018-07-18" version="1">MAIVAASTSSTAQLVVSGYDMRTHAAAEPGKSCAMDAPRVATRSCMSLCHELLDVSGSAMRTVVAGVGSGRAGVRPARKDDGLTRSILCSKQSTLLCKRHSRGRLTRQRRASENGNRDAGTGGSVAECISPHPARNKVRHATAGCDSERDRPSINDSASQPRRRISCLSGVPLAPLPQSPGRANEKTNGWIRCSKGRCELCEAIRAEASSRSSSSCQTADSRRRRCECCGQQGGRDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ13</accession>
    <name>A0A2T4BQ13_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1365757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ13"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ13"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="42338" checksum="819079CF7921BCED" modified="2018-07-18" version="1">MGQFLSTILSLRTVPPLLKLPTEILLLVASQLSSSPESLVTLSLTCKNLSSILDRDAVDLCEASKRRLLLLLERDFGDAFFYCSFCCRLHYFSQQWHPKVLGAFRPSQRCFLYHENKMFHPTPDSYQFVLYYIYGRLVMNRHFYGYPKGLPLERLQCSAMVSSWGGGPSWQEDHSARIINDELFICTTHTIAGRASTLRDAIDEGRHSVCMHTATDPVDLCYPHRNRIYRMPEFLEPEGDEAHGSTLPVRACRDVLGACTVCLTDYVTTIERAEVKEITMSDYEVSFIKQLSVGPPVDGWFITITAYHRLGRCRDPEHWKWVTLTETPVARVISKGPGQPRRDMVVFPPGAIRETWRTGRSPPQSPVTWGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ15</accession>
    <name>A0A2T4BQ15_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gti1/Pac2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1344384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ15"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22771" checksum="99E266023CF0E962" modified="2018-07-18" version="1" fragment="single">MTTDQPQLVPTFHGFINDTTDALILFSACLDGIISHVPRRPHDRERQRLIISGSVFIYEEHASGIKRWTDGISWSPSRILDNFLIYRELQRPFPPGEKKRALKRKRNGHGVQKPTSNSSGATADIERSLVGSLTDSYDFKGDGLVKKTISINYRGVPHHLVSYYDLEDVKFLPTPTGDPNFAHVRIRPELYLNQNFRTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ84</accession>
    <name>A0A2T4BQ84_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lactate dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1395598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ84"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ84"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="48"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="131"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="359" mass="39438" checksum="591C6B638822FC85" modified="2018-07-18" version="1">MTAKRLKIAILDDYQGVSEKHFARFKDDHEIAWFPDTLPPYNGPDTPQSVKDALVKRLEPFNVINTVRERTPFPAELVNRLPNLQLLLTQGRRNLSLDLDAFKARGIPVATAIHAQATGENTVESTVEHIVTMIMAVARNIAADDAGLKAGLWQANLCTSLSGKTLGIVGLGRLGGAAARILHVAFGMKVIAWSQNLTQDIADEQAAHFNLPVTNSAGEKTFKAVSREELFRTADVVSLHVVLSDRTRGFITSQDLNLMKPSAFFVNTSRGPLVVEQDLLDTLKAGKIRGAALDVFWQEPLSRDSEWRSDGWGKDGRSHLLVTPHTGYVEEAAINGFYEQAANDLEAWIAGKPLKLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR94</accession>
    <name>A0A2T4BR94_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1343363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR94"/>
    <dbReference type="STRING" id="983965.A0A2T4BR94"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="210"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="501" mass="55014" checksum="215BC5DFB7381D4A" modified="2018-07-18" version="1" fragment="single">DKANAKREGPTAVVLSPTRELAKQLSDHIKALCDGLPTAPYVCTVTGGLSIQKQQRQLEKADIVIATPGRLWEVLDGDMSLQDSFTKIKFLVVDEADRLFKAGQFKEAEDIIGALDRRDPEADEDDEDDDLPPRQTLVFSATFDKNLQAKLVGRGKGSKAAAGSDEEKMEYLMKCLKFRGEPKYIDVNPVSQMAEGLKEGLIECGAMEKDLYLYTVLVLNPGRRTLVFTNSISAVRRLTPLLQNLGLSALPLHSQMIQKARLRSIERFAAAKSSILVATDVAARGLDIKEVDQVLHYHVPRSADTYIHRSGRTARGDRSGVSVILCSPDEVLPTRRLASKVHSEREGGGGVKREHFIETLSIDRKIASRLKTRVDLAKRIADAVLAKEKGHSEDTWLRNAAEELGVEYDSEEFDGTAPGNWGGRGGGRKKKEKEARQLSKAEMGALRAQLREELSKRVNLGVSEKYITGGRVDIGALLREKEKGSVGGLFLGGDGLFGLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRL3</accession>
    <name>A0A2T4BRL3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1364502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRL3"/>
    <dbReference type="STRING" id="983965.A0A2T4BRL3"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="217" mass="23900" checksum="EC445060E7BD33CC" modified="2018-07-18" version="1">MANPRVEELPDDETKTKPTVEEQHDESSDESDAEELGDGSLPAGSTAVVHSRYEKKARKALLEKGNLVRVPGITRVTLRRPKNILFVINNPEVYKSPNSNTYIVFGEAKIEDINATAQQAAAAQLAQANAEAEHAGHNHDHDHDHDHDHDHGKEGESAEAKKEEEEEDDGEEVDAEGLEDKDIELVMTQANVSRKKAVKALKENDNDIVNSIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRT5</accession>
    <name>A0A2T4BRT5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRT5"/>
    <dbReference type="STRING" id="983965.A0A2T4BRT5"/>
    <dbReference type="OrthoDB" id="3540486at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="395" mass="46438" checksum="51AE8F9C2F3D0965" modified="2018-07-18" version="1">MESQSISFPQFALLPTELRLAIWFYCLPHRVAQRDNPFQIERLREEQKCWSIRPSLKNAAPPRIASVCRESRQVAMRWGKMVSQDYTWNLGPIWIQPRLDTFHLNFTPEAAWNSDGGPWEPREFLIDGLNWLDEVPLSMSAEYYFQFDLEMLDLAMMRYTPCIKIKDNLVDEDLDVVYNEYAECYPRPFTKVSLSATMAFIIIHAQRRHAVASGLFGLLLDAPVQLVDFDDEQRIRSFRILFESDSSNRKRTEVIGLFSRILSPVFRSRVQAWRDKVDWLMMATAWLRAKMNRENCIPFDEGPLAAWNPVIEDYEDGRRLIYMRRERENYENLFDNENPWVIQAKKELPRVAPKILFMLCTDDCDVDGNVGMVPSVRHSPTENDFYEVRGGYDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRZ4</accession>
    <name>A0A2T4BRZ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1342831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRZ4"/>
    <dbReference type="STRING" id="983965.A0A2T4BRZ4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB72087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="454" mass="50917" checksum="322B02781CFE9228" modified="2018-07-18" version="1">MIFIADKDAAQEILEKKSAVSGGRPIMPFANYCGFANFTNMHQLEKKFTAQRKAMHKALGTKAVVTKYNEILEREAGRLLLRTLDNSDKIIKHFETEAAAVILKIVYGYTINPRGPDPMVILIERMIANFSRACVPFARLVDFIPALKWLPAGFPGTGFKAEAEQYGKEIRAVVEEPYAFALKQLAERNFAESYVARLAQEYTGDKDELSEDDAYTIKWSAATLYAGGAETSVSVLVSFIMAMILFPEVQRKAQEEVDRVTGGTRLPVLADREQMPYIEAMVTESLRWCPIVPMGVPHVMSEDMTYGGYDLPKGAYILMAIRDFAHDAPAYTDPDDFAPERFLAPRNEPDPRWTVFGFGRRVCPGRLLADTSLFLNMASLVAVFDMTKAVDEKGNVLEPKLDFEAGIIARPKPFPFKITPRSEKHTELIRGFEREHPWEESDAAQLGELPLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSG1</accession>
    <name>A0A2T4BSG1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1363761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSG1"/>
    <dbReference type="STRING" id="983965.A0A2T4BSG1"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015544249" evidence="2">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="417" mass="43984" checksum="86F5CD6C4A9F57D7" modified="2018-07-18" version="1">MRFSSIAAVAAIAGLAQAHPGHDLTEEILERRQFVNSVHRKDLSHCAEKLRARGVEARSIARRSAAVEEARALRGFSKKDLQDVLSESHNESSLAYTPDTDPSKLFSGNSSCLLTPEVTQGPYYVGGEFVRKDITDSQPGIDITLDYQVIDVDTCEPVPDVYVEIWHCNSTGVYSGVVANGNGNSNDETNLDNTFLRGIQETDSDGVAQFKSIFPGHYTGRATHIHVMVHTNATLLANKTLGNEIYASHVGQTFFDQDLITAVEKTSPYSTNTQELTENDNDDILAEEADDVDPFMSYVYLGDDLNSGLFAWIAFGINTSYSGHITPAANYYEGGGVTNENAGMGGGPGGPGGPGGFNGTRGMPPGTGVPGATPSGTASSGLKTSTVATITSTGGGVSTLLPYGAVAGGVGLAMMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSV0</accession>
    <name>A0A2T4BSV0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1385046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSV0"/>
    <dbReference type="STRING" id="983965.A0A2T4BSV0"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="765"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116234" checksum="B0B7B96D874C94A3" modified="2018-07-18" version="1">MAEAKSQAASLFEHVAQADLVRLKDALSIEIVDVDVRDPAGRTALHLAVLAGTADVCQLLIDHGASLDIWTGQGEAVVHLAAKRGDVDVLRVIMDAIQLKQRANEDDKAEEKTAVGYEASLSVHVDSLTHKFKMSALYIAVALANVDVAETLLTRYHANPNIIVGYADVHKGTRTVHVLEAALQHPRDVCRSLLRLLLQHGASLLDPSSHTVTESLFFMIMKRGEDALDIFAELDAENFTRAVTKGLWIDSRRCQCALTGVIHLGLEDTAFKLLSYGAPPHVDFKSPLEIQVDSSPFRKKSLETAEDDFWQPILSAALFEMPRLVMELLDRGADPNTRLTEHQACYMVNQRECRTVLDLVKSKLVELRNWNIDDESANYETRGTPEEAKQRAGKQNAVTQLIKAYEEAEAKLVSMGAQTSAGLNLQGPQAPVSQQSFKGIQLHPPPAEINVQLLPSSKITDAKNLETVEDGRQSLLAACRDGNTALVKALALRPWGPNPEFPPIAISSISGYSQGPFLVAVENRHYDLARIIVQIATVQHIDFADSESSDICKQLADDEHSVDSIKKVSAQVKSTVTAKQIVADSHSCFAGEKRKDMDMLRFFIEMESSFPREQSDIERHTRHAWALVEHGDWPAAFEEYIKATGAPFRHVVSQGKLKWKCQLDRLHQLSPLLQAAWSGNLHMVRFFLDKDRATAAYRYFAEKNDFSSRKAGPEASRAEFLDVVEKWMDKRKNLVLHCAIFSRSIDLVKFLLSTHPDLLEVQSIDGWTPLLTAALHQRIEVLHLLLEAEASPFATDLVGRNMLHLLLVSPGQGYIQEPAKLSSFLQSMDRSVLHQLLEQRCDESPGGLTPLARWILTRPSPDGLFTSLLDLSSTATLEVLDGRGHTLLHTVACSSMEQLVRPVIERAPHVMFYEDIDGKTPLDHAVDKQLHGFIEYLMPSYTRDRKWQASSPLVHWPLFAFGSDYTGPTYPRDPYQMWEISRELADSMKSRHFTRKLVTAKQREEVARMSKNRMMQKNPKGDQHDVVSLSVYKPGNLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSY9</accession>
    <name>A0A2T4BSY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1425568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSY9"/>
    <dbReference type="STRING" id="983965.A0A2T4BSY9"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="495" mass="55527" checksum="725373607E607B86" modified="2018-07-18" version="1">MATLASPQEWPASALILVAATVVVLLARLLKRPGLPSGASWTEKGLPFFGSFNFFTKRGDFLREGSKKSPNGHFNFYYGSYPIIALSGEAARASYFTTRGLDLSAGFRKLFSAGPDIDRMLGCNMSAYFIILFKRLTGKDHLASCLPHLINDAQASYAAIDTSVPMDPFVNLWNVLYKMTHRTVGCHEVAEDPALQEKTMRYYEKLDKSSAIQVMFPWLPTPTKLIKIWAGAKLHMLFGDIIRDRRRTGRKKQDTMQILMDRGESDLLSSAFIIGALFAGLFNTGVQSAWILCYLAHDPVWYAKVREEVDTVVAKYRTSDDQTPVDVLRALSLEAWESEFPCIDLGVRDSIRLNLMGASIRQNTSGKDIAIGDTGVVVPKDAFAVYRVADIHMDEAVYRDPLKWDPARYLPDRAEDKKEQHGYIGWGTGLHPCLGMNIAKLELFVSTAVFFAMFDFKAVDKNGNPTTEPLPRYDANALSAKRMIDTVYFKCDRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT82</accession>
    <name>A0A2T4BT82_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1091091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT82"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="17906" checksum="0F3C59ADE8B92A2F" modified="2018-07-18" version="1">MGNSNGVLAKALYYRHEAGVTGWKKRESSPYFMMERGGLGSVAGCQNRSPARSGSQSRVVRVPSYEMGPDAVQRHTHTTGSACLFLCLDNIQESSAHGKSDATPAPLLVGKTCSHPPSCAVSQSYITCPSDFELRCLLVSVQKWEGEENVAPFRDCIVVWRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUE2</accession>
    <name>A0A2T4BUE2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_59763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUE2"/>
    <dbReference type="STRING" id="983965.A0A2T4BUE2"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="399"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="694" mass="77330" checksum="BFEDECA8AAFD3DD2" modified="2018-07-18" version="1">MSWDLLQRFLESDVFNANPFLSVSYLSRYADHVGIHYVLCNKLRQFPYEDIEFFLPQLCHLIISVDNESMALEEFLLDLCEESVTAALLTFWLFQTYLHDLSSNPQSNAFQTCRRVYNKVQHIVFGLADTARQNKIKENVLPVAVLSSFVLASVALPMIPRWAGPLAVAQARKPQPITEDASDGSETPKPIPPATPTKPTRANTIASPISKPRRVKEPKSPSASDPHPEMDARPSPRRAGSQVPISHSPLNPAFNPDSKRPSALDMKSLEARLSTASLPLPSPRGPSRPATPVSAGVNARPSDGIHRRHSHHFKSHLSPTNLSPAQKAQLLRQHYFRSQTHAIQGVDPDLDEEEAAPVDPNINASAGRERMENDIKTGGVQRRGDRDDPSAAVFGEAWEAKKERIRKSSPYGWMKNWDLVSVIVKTGADLRQEAFACQLISVCHKIWVEAKVDVWVKLMRILVTGESSGLIETIANGVSLHSLKRSLTLASIEAGTNPRHRIATLKDHFIKAFGQPDSKPYKAGLDAFKRSLAAYSIISYILQLKDRHNGNVLIDSEGHIIHIDFGFMLSNSPGSVGFEAAPFKLTHEYVDVLGGLNSPDFEDYKKLCKQAFQALRRSADYIIDLVAMMGRDSKMPCFAVGVAHATTTLRQRFQLHLSADEAENFVETDLIAKSYGSYYTRLYDTFQYRTQGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUG9</accession>
    <name>A0A2T4BUG9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1472294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUG9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUG9"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="86"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="283"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="460" mass="50115" checksum="DEE0E1638ABEB1F3" modified="2018-07-18" version="1">MARPRQHARQITVDASHVVVPVESRLFPGLPPRLGPAYAEMLFPRSLAKAIGGHLEHATSSRPPIEPPRCEEALRHDAHTLPGDHTLIFILSYIAMAPCANLIGFAGQEFARKVPHVWGVLIETTVGSIVEIVLFMVLLHMNQFLVIKAAILGSILATMLLCLGFCFFVGGIYHEEQTFSDTISEAGSGLLLTAGVGLAIPTVFSHGLPDDSTLSAAEISHKTLSISRIVSVLLIIAYCVYVFFQARTHHGLYHAIFEMDEERDRDGHKDAAKDKLTMTECIIALTVAVTLVTLIAITLVLQIEHIIEKSKVSDAFMGLILVPLVEKFAEHITAIDEAWDNQMNFALSHVLGATLQTALFNAPLVVIVAWGRGKLLDLEFGIFDLVMLILAILTVGRFLQDQKSNYLEGFLLVTLYVAVAVSAFYYPNPPHAEGAGAEGGEGDHGGAVPGEGGHERFRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUN4</accession>
    <name>A0A2T4BUN4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1070351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
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        <property type="protein sequence ID" value="PTB73012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="223" mass="24492" checksum="8DCE93CE3B9A1EFF" modified="2018-07-18" version="1">MAAQSTGHRIPAIENLGAAGPHDAIDFTDNDIQVLGNFPLSPRITTLLLARNRVASIQPTLASAVPNLRNLVLASNNLVELADVDALGGLARLTHLVLADNPVTKKEHYRYWVIWRCPSVRFLDYEKVKQAERDKARELFGTEEEPTALATSIMGKKSKLDVTANGSSAAPSKLSRIKLTDAEKQRLQERIKKATSLQEIIALEKELNEGRLPSGVYGDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUP5</accession>
    <name>A0A2T4BUP5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1070410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUP5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="16235" checksum="10E6AF43609AE8EB" modified="2018-07-18" version="1">MALSKAMFFGVAERLLPFAPTVDTSIIVLECLDRALDGCSPGIAWHLSPWSPFAPRISRSALGNEGNRADNTCPFPGSLAHQRQLTDSKENFRKWNGRRRGTRDPSLACGAAVGPRAWSVISELLHRAALVADHCPLVAASASLSCCFLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUS3</accession>
    <name>A0A2T4BUS3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1441350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUS3"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="454" mass="49827" checksum="1D39B9D01273AB2C" modified="2018-07-18" version="1">MLEYFTYKKYKKNKEEKEAAAKESPKKNSDVTKDANKDQATKDANYDSSASELIPPAKAVLKPEDERFLEELLAQDDGPPPPLPPRIYTYDVDWHSDTEVSDVESKKTTDDETEEPGKAKVANKKEDEPDKAQDKAEKKPNRLSLLFTRNKKPAETPVKASTTLQPENAEGVPPKEVEREKKDLKRVLDRLNLSARSSNSSNKAVASASDADADSSDLLQRFTQVFRDLVSGVPTAYDDLTKLMEDRDGTISKLFDKLPSSLKQLVTQMPDKLTTTLAPELLAAAAEAQGINVGQGGMKGAAKRMLMGKNLANLIKTPGAIVGMLRAIVEVLKSRWPAFIGMNVIWSVALSLLLLVLWYCYKRGREERILREEAEAGAESSSRRYEELSDDEDEAGQGDKRVTGSTEAAEAAEVIPVIITSPEGEVLATEIPKDAATPDVEAPSPDAPAEKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUZ7</accession>
    <name>A0A2T4BUZ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_59434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUZ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BUZ7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="496" mass="53859" checksum="626E89070CE22A52" modified="2018-07-18" version="1">MALTVELNTPITGPYTQPIGLFINNEFVESVDKKKFEVINPATEEVITSVCEGTEKDVDLAVAAARKAFNTTWRTTSPGERGRLMLKLADLAEKNLELLAAVESLDNGKSITMAKGDVGAVVGCIRYYGGWADKIEGKTLDIAPDMFNYTRPEPLGVCGQIIPWNFPLLMLAWKIGPALATGNTIVMKSAEQTPLSALVFAGLVKEAGFPPGVFNLISGFGKTAGAAIAAHMDIDKVAFTGSTMVGRSIMKAAAASNLKKVTLELGGKSPNIVFNDADIEQAISWVNFGIYYNHGQTCCAGTRIFVQEGIYDKFLEAFKERAQKNKVGDPFHHETFQGPQVSQLQFDRIMGYIQSGKEEGAKVEVGGERHGDKGYFIKPTVFSNVHPDMKIMREEIFGPVAAIAKFKDEEEVIRMGNDTNYGLAAAVHTRDLNTAIRVSNALQAGTVWVNCYNLLHHQMPFGGYKESGIGRELGEAALANYTQNKSVAIRLGGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV12</accession>
    <name>A0A2T4BV12_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1425126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV12"/>
    <dbReference type="STRING" id="983965.A0A2T4BV12"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="506"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="583"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="643" mass="65984" checksum="825F2B51CF177B0B" modified="2018-07-18" version="1">MSTQTPQVLSRRANASAAGSTKGKAAADRPGKAKGSAEKHGEARSAAHDADTPRATKTRAPQEGEKVIIRRLPPGMTEAECLSILGSEWAVGNGKVDWFSYAVGKVSNELSKPSRPARAYLHLMRKEYIMPLSDVVRNATWEDAKSTFTSPSLIGPPVLEIAIYKKVPGNKKRVDARQGTIDQDPEFMAFLEGLANPAPPRESHENDDVEEPAESKVTTTPLIEYLKEKKANKAKEAAAAKSAKHARQQEASASKGKSASKDDEGSKKKGKEAKNHKSEKPAPKEPVKILTKKAATAEQSADASKPAPNQASNASTSSAAASAAEAPTSKSRRAGVSIAARILQRDLGLSPGSAYRRARQDAAKAEAGSKPSAAEKDGKEQPSLANENTGPSAPAPAESTSAQASAKDNASKSQQSARKTRGGKNADKAKASESPSTTTSVILKKKGGASGDADAAKSAPETASATQQTNSSKSTTGAANGPKGASAKSSVSQKKSGAASSSANATRGFVKHANSSQGITEPVLKQALEAFGTVTFIEVDKRKGFAYVDFADHASLAKAISASPISVAQGTVQVLERKDKKPAAAASSGSGSATAAPSAANTAKDSAAPEKSSNTNSGRGRRGRGGKGAASTNGTAVAATSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV83</accession>
    <name>A0A2T4BV83_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_7600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV83"/>
    <dbReference type="OrthoDB" id="3358048at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="218" mass="23897" checksum="CEA62FC36938A4D2" modified="2018-07-18" version="1">MPSPLSLSDQTTRLRRTFHYPHDSDSDSPEAMDEQEQDNLIQTLTAQNASQNTTTARTLILLPLLSTIAYVRPLFDPATASFAIFCLTSLLATAFLLYRLPPTETGIAVVDDWAHKRTPANISLRQHNQTLRGLLGRAQVEMRSPLERTLPYLNLGLVVLLSLMGLVRGEQRGGGFGWVSMGNVPGLVYSVAITAKIVMAGVDPERELSGLKYGYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVE4</accession>
    <name>A0A2T4BVE4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1340187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVE4"/>
    <dbReference type="STRING" id="983965.A0A2T4BVE4"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="10">
        <location>
            <begin position="70"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="9">
        <location>
            <begin position="518"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="11">
        <location>
            <begin position="691"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="237"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="743" mass="84256" checksum="7FA89FABEECE1FF0" modified="2018-07-18" version="1">MVKRKVAALEKIDADFASLQYKIRRDPKSYKDDFLKQWEQYEAQREIFFTSPTAAAADTIESFHNMIDLIAHVADCYPEETRTFQDDLKAIVSQHHETLHPELRDKVVGSLVLLRRKEVIDSTSLLTTLFPILVSSRSKTMREMLFQKILSDMRNSNSKATNHPLNRTIQAVLYNLVTADRASPRAIWAIKLTRELWKRQVWTDAKPVDVMKEACLADNEKVIVGATRFFLGGDKEREELEDESSDEEIDLAKVKHQITINKKSRKQKEAYRKAVDKVKKQEKKKTKPHPLNFSALHLLHDPQEFAEQLFEKHLQGTKNKLSLDTKLLVLQLVTRLVGLHKLTIVPLYSWFIKYLTPKQQSVTSILASLAQGVHNLVPPDALEPLIQKIANEFVSEASASEVAAVGLNAIREICSRQSLAMTETLLQDLVQYRKSKDKGVMMAAKGLLSLYREVGAEMLKKRDRGKDATMGLSSGMMKQRKFGEEEIGGIEGLDLLAKWKEEQRKRKRAEKGLPEDGSDDSDDEKDVEEDDGWEVDSDDSSESGEWINVEHSSDEDEPAPKKRKGENDEDDDEEEENAEDEAAELERMTKLATTTILTPADLAKLQELRAAASVQKAMGARARKRQQQADANNGATHHDDGLTAENIEAPIRLRKLTKEEKVALAKEGKPDRDEHKSTQAIRKSKKDAAGKSTSNREKQRKKNFLMTLGKAKSKQKRSLVETRKVLRGHVERSTRGGRRRNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVE5</accession>
    <name>A0A2T4BVE5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1425218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVE5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVE5"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="102" mass="12263" checksum="43B6815EAE65FE1B" modified="2018-07-18" version="1" fragment="single">READRPGVWSCKNKHRYASQDLWPMRVTEFEGVKARIPYNFEEILRAEYGDKSLVVEEFQGHRWNRDINEWVQMTPDEIKKSKEAAEQRKKEEEAAKQEKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVI5</accession>
    <name>A0A2T4BVI5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF689-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1432906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVI5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVI5"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="219"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="321" mass="34043" checksum="F3079ABB2DF4DD51" modified="2018-07-18" version="1">MAPSVVTIDTSDDFFAAPVATESKRTLLLAPPSLASHPSALTSVVSQYDRSVTDLQMIDRLSAGLVKLPPATYDLVLVLADASSSLNETLPLLTRNILGPVAESLKPKGRLQSQDGSDLGQDAALAKEAVLAGLVASNGGFDKPDYGDGEGVVSLKLGSRKKKTEAPAVQKVEEVKTAAPVGVGFIDFSDDLDADYDDDELIDEDTLMTEDDLKRPINIPPECQPKPGKRRRACKDCTCGLAERLEAEDAAKRAAADQALQSVKLAADDLTEVDFTVQGKVGSCGNCALGDAFRCDGCPYIGLPPFKPGEEVRLLNNEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVI6</accession>
    <name>A0A2T4BVI6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1404349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVI6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="13233" checksum="43F88020A528A717" modified="2018-07-18" version="1">MLLVNGRRLAGVAGIVAVGFHVEAEGAGMPCSSGLGLAASPWRSVCSPGPHDPGSVAVRTLPCTMAASWNSVPAAKVRRSPLCVRASCISSRLWAQRWRHAMADRLIRQSLRCPSSARTVCAANTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVM1</accession>
    <name>A0A2T4BVM1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1393940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVM1"/>
    <dbReference type="STRING" id="983965.A0A2T4BVM1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="342" mass="37890" checksum="24103C5B64BF1005" modified="2018-07-18" version="1">MEFLLSIPMISYFLGPALTSWSTSLNLLFFYMTWSTLVLSQPPLVVHTVGILAIRIVFFLLPSLLTLLFDISLPSLAEGIKHGGRSALPPRDANSLSRLLGLVLLNIAILTAVEAGLDFAFTQLFHEPLFKTTTTLPLPWQILKHVLILLSARETLLYTIHRFILHAKSSNSSIIKALARRHQKYAHSKAGAPFSLRLLADHPLPLLCYKFIPLFLPAAILRPHILTYFLVFLLCTGEETLAMSGYTIVPGIIMGGIVQRTAIHYAGKGTSNFGSWGILDWMNGTSRGRDVLDDVKKEADKHQLKQRSAKKVDQGAGAVQEGLDSLREGVRTRSRGRKKASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW61</accession>
    <name>A0A2T4BW61_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1064635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW61"/>
    <dbReference type="STRING" id="983965.A0A2T4BW61"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="198"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="393"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="669"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="795" mass="87464" checksum="3DB6E8D7263D53DC" modified="2018-07-18" version="1">MANESTPLIQTVRVGPPRRRYRHHTLRRFCTIACASLLLCGFASFALHSLYIWPSGQEHRHRHPHHPHHGHPGHGHKHLSHEDLQAILLDTPSAEKAEEWSRYYTSGAHLAGKNYSQAEWTKNRWEEWGIKSSIVAYDVYINYPVDHGVSLLEKSSDAKSWNVAFKASLTEDVLEEDPTTAAKDKIPTFHGYSASGNVTGSFVYVNYGTYRDFADLVEAGIDLEGKIAIAKYGGIFRGLKVKRAQELGMVGVLIYSDPGDDGEITEENGYAAYPEGPARNPSSVQRGSVQFLSSRSGDPTTPGYPSKPGVPRAPADETTPSIPSIPISYADALPLLKALNGHGPRASDLNKWWNRKLGLGYKGVDYNIGPSPEDVVINLYNEQDYVIAPQWDVIGIINGTIPNEVIIVGNHRDAWIVGGASDPNSGSSVLNEAVRSIGKALEAGWKPLRTIVFASWDGEEYGLIGSTEWVEEYLPWITDANVAYVNVDGGASGPQFSAAAAPLLNQVLRDATHLVPSPNQTVAGQTVGDVWDGKISTMGSGSDFTAFQDYAGIPSLDMGFGGNGSGPVYHYHSNYDSFHWMSEYADPGFVYHRTMAQVLAVLIGELVDRVVIPFGATEYADALDSYLDKVVAKLHPADTELATDDEIFAVRGSVSSQEVVGSQDAFEESLKKIRRSISEFRNKAVELDERAAWAQRKLEEGLPWWNIIGKARLGLTIVKVNRQYKYIERQFVFEGGLDNRSWFKHVVFAPGLWTGYAGAVYPGLVESIDAKNYSNGLKWAEIIKHAVDKATKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWG3</accession>
    <name>A0A2T4BWG3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1404575</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWG3"/>
    <dbReference type="STRING" id="983965.A0A2T4BWG3"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="100" mass="11506" checksum="7D2B68D88DD89FCE" modified="2018-07-18" version="1">MADKPAEVAAAREKLEAQIKSADMTDDMQQECIEVAQEAMAKFTIEKDIAQHIKRTFDERKGPTWHCIVGRNFGSFVTHETKHFIYFYLGHCAILLFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWQ3</accession>
    <name>A0A2T4BWQ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1050673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PTB73739.1"/>
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            <begin position="1"/>
            <end position="51"/>
        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
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            <begin position="121"/>
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            <end position="264"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="394" mass="42434" checksum="B47ECDCD8C7CCD97" modified="2018-07-18" version="1" fragment="single">VSDLQVRIPKLWQDPEPPKPKKKRDSGGAADDSREEKKRPPAQNPVALRDTKVNGAYCTLKILKELRRITHTSPPPPSSLSLALALAGAPPSSSLPVTQPPLSRSSAAVAHPKITAPEPPTTTEAVPRAAIMDPSRISTPRGKAKRPRRSASGALERPQRTPSTLNPNHGRSKKPAAEPPEEQPQEVPETPSQPPASTVEDFSSILHSVKSNPRIRKRKMIDGEEFVFPAVGKKRGAVDSLYKGPGDDTKELPPLRPMPEPISPSPVAALPVEEEGSVEEPLASISVNVRAATTFARPEAFYIQDPLVTLLEKAPQWKTLEAKQGEAKRSKRRVSKRFLPMQMETKAQAEANAALALAGLKTNSPMMAEVAHSVSGGGGLPELASWAATWSCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWT8</accession>
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        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1471791</name>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7702"/>
    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
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            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="258" mass="27712" checksum="F0F473B49C01BE5E" modified="2018-07-18" version="1">MLNPHESLGIAQIVFYMPIVPAAIRLMYRNGQILRLAGGPVTIALEQSSSMGLYSAAILLLNVGVVPLIIATLGFVRIVLLDNYTAPSRARTLTALMRGALAIAICLLVAGGTISSFDEPFEMFLSRTLTLVGYIVFAVMHIVLIAFMGFLYSRRKEALLPSSRSILRGGLLAAPFLIIRTVFGLLEVAFQDSSSSPFNPVDGNAVAFALMALLPEYVVVLAYLYTGFAIAPDRGVIAREVVGEETVTVTQEAAKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYB7</accession>
    <name>A0A2T4BYB7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SWI/SNF family DNA-dependent ATPase Ris1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1403688</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYB7"/>
    <dbReference type="STRING" id="983965.A0A2T4BYB7"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="419"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="764"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="959"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="839"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="875"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126163" checksum="9A7D6872BC944071" modified="2018-07-18" version="1">MAGKREALREELMVQEVILESLQGETFDDAEQQREDAKREISRLKRALKALPKMTSADEGGPSNNRAQAQRATSQTSASPQKQPGQGRARTPVSAGPSRSSQPSAVMETPRRPLASQTGESPSLTVRSRKRDFEASGLHAGTNLASQRRAAPGLFSGSQNPSWSPSSDEQIEIIDLTGADVDYDSSKIVEQLRQERERVKTEKGKATTASQSSSQNASGPSAASNSGQPSAFSRMMATQRLNQSQTVLEISDDELEPPLPNLVARGPAYGPSAGPSANGHIVPGMNQPNPNPHYYRLPTGNLPMPGAYPGAPMMWGTPIEASALGRGTLTPLSDIINRTSSFDYVNGVDGDGNTLPSHLMDFINNSFHDPRVTEQELDDLLKNIRPDMDIPEDKRDGTPEGLKNALYPHQALALSWMKQMEEGTNKGGILADDMGLGKTISTLALILSRPAKSRPKTNLIVGPVALIRQWEEEIHKKTKPSHRLSVFVYHNTKATIDEMLKYDVVLTTYGTLAQEMKRLDSYLESNAGRNIDFADKGIATKFPLLNPRKSKFYRVILDEAQCIKNRNTKTAKACHRLSAVHRWCLSGTPMMNGVLEIFSLVHFLRIKPYCVWDQFRRDFSPLFNKNSATDGVAMHRFRALLKAIMLRRKKDSELDGKPILVLPAKKEQVIYADLSQDERDYYDQLEKASRVTFNKYLREGSVGKNYSSILVLLLRLRQACCHPHLNLDVEDTAPSVTTEELLDLVKKLDEAIVVRIREADAFECPICYDAVQLPSFFIPCGHDTCQQCLTRLVDSAATTNLQQGNEGVATAKCPVCRGSFDPKKCFNYETFQQVHMPECVERPVKDEEDESVSSGDDDDEYSSEDVDDDEVDSYGDLRDFIVRDDVDPESERQQIESEKEEKKERRKKKKGKKKVTEIKPSMLRSLRHDASKSRAAYKKYMGYLRKTWLPAAKVSECMKLLQEIYKTGEKTIVFSQWTLLLDLLEVAMWHDQYPGKMRRYDGSMSAEHRFQAAVDFRDKKDVKVMLVSLRAGNAGLNLTAASRVVIMDPFWNPYIEMQAVDRAYRIGQMKEVMVYRILTKETVEDRIVDLQDRKKAMVEAALDEAESMKIGRLGVNDLKFLFTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZT4</accession>
    <name>A0A2T4BZT4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1036569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZT4"/>
    <dbReference type="STRING" id="983965.A0A2T4BZT4"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35321" checksum="FE84B230F6DBA767" modified="2018-07-18" version="1">MASDLDTLIEMGFERARAELAVKKSGGLQGALQWLEDNQDKSLEEIQAAAKDDEEDEDETKAKIAALESGESAKSLVCNECGKRFRNHDLASYHATKTEHTDFSESTEEVAPLTEEEKKAKLAELRERLKAKKASQAEQDKEDAKRNEKIRQKSTKESQEAKEELARKEQIKEAMQKKREKLEEMEAKKRIKAKIEEDRAERRRKAEEAKAAREGRAPEAAASSSSAAAAPAAAAAPPRPKADHTEAKLKLQTDAGNVMKTLPAETTLFELAQQLEGEIGKPVTTFTMTFPRKTFQGDVDMSKTLKEAGLVPSAVLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0K0</accession>
    <name>A0A2T4C0K0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PNK3P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1458504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0K0"/>
    <dbReference type="STRING" id="983965.A0A2T4C0K0"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002548">
        <property type="entry name" value="DNA kinase/phosphatase Pnk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="465" mass="51863" checksum="D432E4D92A291504" modified="2018-07-18" version="1">MATKSPPRKRKDAGAPISPPPLKKAVKSTTTSIFFTPASQKPKDRTVWSERGPTDDVPATLLVGRYQPENDDPTSRQKRRKIAAFDLDSTLITTSSGKKHASSGADWKWWDSKVPGRLRELYEKEGYHVAILSNQAGLKLHFDAKYKGPKAAVQKRVADFKQKCNAVLTALDLPIALYAATEKDIYRKPRTGMWKELCEDLEIPEEEVDLKGSFFVGDAGGRVALLGKGDSSAATAAAAAVPKDFSCSDRNFAHNVGIDYKTPEEFFLGEEPRDFIREFDLVNFAFPEDEASLGTAKDLFEKKNDQDVVLFCGPPGAGKSTFYFKVLKPLGYERVNQDTLKTRDKCIQAAKDLLKAGKSVAVDNTNPDPDTRALWIEVARKASVPIRCVWFSTPVIVCEHNDAVRAHNAALNPEARESLPKLAFTGFASRFKEPKEKEGFQDVTEVKFQFRGTKEEYALWGRYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1D5</accession>
    <name>A0A2T4C1D5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">M440DRAFT_1379592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1D5"/>
    <dbReference type="STRING" id="983965.A0A2T4C1D5"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="381" mass="41326" checksum="DE7AD102B4A56205" modified="2018-07-18" version="1">MAGPEVASRPCLRCKNPDAPYELRNVAACHKAVKRLTVLQRETRTSSRPEPRRYVAGLSFGPCSTALTQILDKQAKYHASRKGSSPFEPLVVHIDTDLSSSNNNNNNLADDTPAQRLLAKYRERFPNVSFECIHLSKVLGLKTIDWTALPVAVAAGENDTERLRHFFSALPSVTSRADCLRLFVRHLLLGVAMERSYSALLLGHSTTALASLTLSEVANGRGFAVPWQINDGPFTVCTYGSAAGQDDAGKVQFPIFYPLREILKAEVVTYLSTTPSVRDLVPADSAPSSVVSHKDQSIEEVMARYFEGVEGPYAGIVTNVVRTAGKLDRLVTSRYCRLCGITLDEEGDSTWAGELGDDPAEGGGNGDTGKLCYGCKRSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2V2</accession>
    <name>A0A2T4C2V2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1402424</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2V2"/>
    <dbReference type="STRING" id="983965.A0A2T4C2V2"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB75890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="315" mass="34127" checksum="AD63E473D9F9800B" modified="2018-07-18" version="1">MSSEKPQKVLGMPPFMADFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMIKTGRLERRYAGITDCFKRTAADEGVLSLWRGNTANVIRYFPTQALNFAFRDKFKKMFGFKKDRDGYGMWMLGNLASGGAAGATSMLFVYSLDYARTRLANDAKSAKKGGERQFNGLVDVYRKTLASDGIAGLYRGFMPSVAGIIVYRGLYFGMYDSIKPVLLVGSLQNNFLASFALGWCVTTGAGIAAYPLDTIRRRMMMTSGEAVKYKNSFDAARQIIAKNGVKSLFNGAGANILRGVAGAGVLSIYDQLQILLFGKAFSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C358</accession>
    <name>A0A2T4C358_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1266014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB76000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C358"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015482628" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16223" checksum="1AF1A00CA9B2B065" modified="2018-07-18" version="1">MPNRHCATGAFVVLECCGVTCLGSPAGSNLQTHHGRTSMQLRVARCVLPDEAFSMLTFRNPPYVQFRRQHSVRLIGSARLTQQTLSIKDLGHLYRPGAETNRRARLMMGSNRRWCRTGYYCGELFIKSGADRCVCHPAEFCSGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3F7</accession>
    <name>A0A2T4C3F7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lanosterol 14-alpha demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1355807</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3F7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3F7"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="526" mass="59024" checksum="039D8F7ACF683151" modified="2018-07-18" version="1">MGVLQDAANHRVAQLYFQQGIGAQIAIGAASFIALAVILNVLQQLLFKSPNEPPMVFHWFPFIGSTVIYGMDPPKFFRENRAKYGDVFTFVLLGKKTTVAVGPAGNDFILNGKLKDVNAEEIYSVLTTPVFGRDVVYDCPNAKLMEQKKFMKIALTTEAFKTYVPIISHEVTSYFKRDPDFKGKAGIVDIPKKMAEITIFTASHALQGSLIRSKFDETLAALYHDLDMGFTSINFVLHWAPLPWNRKRDHAQRTVAKIYMDTIKERRALGDQDKELDILKHLMTSVYKDGTPVPDHEIAHMMIALLMAGQHSSSSTSSWIMLRLAQYPNVVEDLYQEQIRVLGADLPPLQYEHLAKLPLCQAIVKETLRLNAPIHSIMRKVKQPMPVPGTKYVIPTSHVLLAAPGVSGSDPTYFPNPDLWDPYRWLPGSPNAPLLVRNDEEEEKVDYGYGIVSKGAGSPYLPFGAGRHRCIGEHFANLQLQTIVCEVVRLFKLSNVDGSNNIVGTDYASLFSRPLEPAKIRWERRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3P6</accession>
    <name>A0A2T4C3P6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1298397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3P6"/>
    <dbReference type="OrthoDB" id="5138316at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="125" mass="14513" checksum="5BC5DD83B4D37C45" modified="2018-07-18" version="1" fragment="single">HEDIEVKLEPVKATRSLETLTTRKPRDATQNAMDRLVQDLLASQKDLEDERSKTAVKDAEIVQLKEDMAHLQQRDYKDCEEANELRRLLAFHIKNGEQLSRRFRDLQAVNKDLQAQLQASEMALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3U4</accession>
    <name>A0A2T4C3U4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1377160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3U4"/>
    <dbReference type="OrthoDB" id="4892534at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015694003" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14348" checksum="ED533D7BFEA6A8BD" modified="2018-07-18" version="1">MQFLTAAFALLGLALTASAADEQLCFPVPGQINNVPQSITDLDVQIKIHWATKLCAQIDYSTVDAQSVTTDVADGVDATENGKTYGLNLVTVAVPNEEKCIDNAAATLGADVCPSGGAFINLDNNEEEWFSIVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C515</accession>
    <name>A0A2T4C515_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1438416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C515"/>
    <dbReference type="STRING" id="983965.A0A2T4C515"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="29"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="259"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="357" mass="40848" checksum="1E926FE87FD6694B" modified="2018-07-18" version="1">MAIDEEELFEDAGDLDFYDKSVPGNTFETLYLARVPKYMWDAWVKLTEKLGDDDEIQIGTLRTWNEPQGDTLPDGSPRELTKLRMLLTPGLPEHQLLPKEYDLEILDQDVNNAFIFSEEDLPGFKTKNKARAEAASAGIPLALLRQRGNNGNTERPTYDRRSRYQPYYRKAIPKKTKIFGKIRYDLRVEPRNLREEEELLAKRIFEAENSKSKLQIISRNKASAIINPGSAGSVNWGGNFIKNAPSVLKPKKTEVLKAARIPKNQLLDLIFDCFRQYQYWSMKALRQRTQQPDSYLRQVLEEVAVLNKSGPFANHYCLSEAYRDKGGNDAKEAAAEAMDEDGDDDEGEEMEDVLVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5B8</accession>
    <name>A0A2T4C5B8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1332689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5B8"/>
    <dbReference type="STRING" id="983965.A0A2T4C5B8"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="444" mass="48673" checksum="00389A1023B15F26" modified="2018-07-18" version="1">MISTRKKSCSACVAGKRRCDLDLPSCGRCRKARKDCVYPWMMAVGGSEQDLGVVSPPLSVGADVTQDMSRIWQAGMDTSSGSSSGSSTSGGPGAASAYLSPDPLSTTVPPPLVPCLLSQLDEYMLQNQGQALLSLSPGLGPMDSPSPGPPSATEFAASPEFVYFDITNTPVTTGSIFQSRTEWAASRFAMQPQILAMTGQNCFVHHTQVASSEVLQEALAASALHCMRNTANAALVRGEIAKRVARLVGSIRRAVTCASEAAALDLLPALQALVVYQCIRFFSRDDVGERMRAERDEAIVQSLLVALYPRLRSFTKTMDGWSSWIYYESMRRTVLTAEILSGTYNFLKQGWDQAEARTLQLKFTAQAALWEARTAVEWEAMWARGPRLQVTVRTFPEDARDALPEDMEDLGMVLWALHHGLEEMEGWMGKRRAVLVRWGLRTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5D3</accession>
    <name>A0A2T4C5D3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_302776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5D3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="20630" checksum="C3A7BB9DD677049E" modified="2018-07-18" version="1">MLRYGHVIKRPEPRALEQPELSLDLSPSLAVNLNLNLNKTTTGQTETRSPQSSSRTSFANAVVRPSSHGIAHIRRPSQSIAGRRSAAQGIKSQAASISHALHTHTTSSQTHTHTHTQLRPQQHLHRIRTHTQTQTQTQSRSSKTQARPDSPTTLRHTAQAFVGVFLAPLLPPKRMSPRCNPPTKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5F3</accession>
    <name>A0A2T4C5F3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_65878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5F3"/>
    <dbReference type="STRING" id="983965.A0A2T4C5F3"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000127">
        <property type="entry name" value="Uncharacterized protein C3H7.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="747" mass="82228" checksum="C53B7BA46F3280F0" modified="2018-07-18" version="1">MTAVANPPTFPQISRPPWATINGNNQMNSEDVRGMFMNRKSISRTNSSSSIASNASNTTVASNGSHSNATSLSSASDLSQWSNGSANRKRPQPKNPWPAGKGDAQSDFSRLPQGRPNGMVPHATMQQGGPGQPQMGPQGMVRSMGPNEQQFPPGQPMLYLLSLNGTFERKTIAVPFAPDSIRIGRQTNQKTVPTATNGFFDSKVLSRQHAEIFAERNGKIYIRDVKSSNGTFVNGTRLSQENRESEPHELQTADHLELGIDIVSEDQKTVVHHKVAAKIEHAGFLNTTNNVLDMNFGDLDPANNAMMIPAGVQMRGRAGSNMSMGNNGRMMVNGGTMNGHMNGMAQQRPFFLTPIATDQILKRLANELRSAKLQAQDLNRTNQFINTLLSKDDLKDVEKLEASEAPKPQTMVNGNLSFRSDPKARFSDPPAPPPQQPLPEKPDVPSLKRGASDRPKLDSATSSPIRQENLSQIIQLTEALNNAKRDINTQTERMRELELMLQKEREARELAEELARRLEESANNVQVNGVQSHERHDEPQESTQEEASDDADETETVLPEAEEMPQADKVAQETAAALQSRIDTMDEQMRELRMQMEQWRARCEAAEAERDSGRKTLEEMVIQLRAEEAKRVAAEERRRSRSRARRTERDEAAEKATTAVSPTPADTEPALKQERSATTPDEVSADVPTLSRANTVTPQASPRGGPLANQHFRAGLPYASMIGVVLLGMGLMAYMNGWQSSPSHAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5T2</accession>
    <name>A0A2T4C5T2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1401273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5T2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5T2"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF166">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G01210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="257" mass="26995" checksum="DADC5DEB18D42F29" modified="2018-07-18" version="1">MSGSASALGELIQTSSPVSGVRVITFNRPQKRNALSTELLTEFLTELSAASKDAAVKVIVLTGSGGFFSAGADLQDIAALDAAGARSCRYLEDLCHGMASVRKPLLAAVEGPALGGGFEVALMCDLIFASQTRTYFALPEVKRGLIPGAGGTQRLTAALGKFKAMQTILLGKPITAVDGLSHGLVCELFEDGTVLDKTVKVAADLAANATEAMQLAKEAICRADSLGRDDEFERTLYYVTFGTEEKKNGVNGFLKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C663</accession>
    <name>A0A2T4C663_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1332248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C663"/>
    <dbReference type="OrthoDB" id="4881101at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="92" mass="10689" checksum="E49AD399A3324E4C" modified="2018-07-18" version="1" fragment="single">ITTTVSPGVDRNLFVPIAPMPRHPVTNRQLQLCDNPYGNSGLPQPSYLRVNRIYEIPPEALVEKRSYHRELELRQKPYDELIDFKKSQNIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C799</accession>
    <name>A0A2T4C799_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTH11-type GPCR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1212726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C799"/>
    <dbReference type="STRING" id="983965.A0A2T4C799"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF166">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="343" mass="38938" checksum="DD33DB49D3D6D197" modified="2018-07-18" version="1">MDSTLIIHWLFSWLALIIMGVRLWGRKYVRQAFNTGDYLTMAACACALIRLGMIHVVLTWGTSNMTAAQRQDHHFTPYEIYQREIGSKLSIANRVFYNSYLWLQKLVLLDLYRRLIRDMPYEKWLIRAYLLVFFATYTIVQVFTFSECKPFHLYWQVLPDPGPCAQAQMQLIVLGVLNIITDFMLLIMPIPVIFKLKVPPGRKAQLIGLFTLGIFIIIITIIRLPINSSHPYSQVNRTTWASTELLTAAIVVNAPTLYSFWNTSRRNKSTPQEQEQGASDKAKDGIVLETIGGSTLSGTGGGKRKPSGGILQTKEVIVSEYRHSGEYIKLADERDHTSQGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7J2</accession>
    <name>A0A2T4C7J2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_282699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7J2"/>
    <dbReference type="STRING" id="983965.A0A2T4C7J2"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51375" checksum="B64BAF463BF09638" modified="2018-07-18" version="1">MSSSPPTPPAVATPEEGNNEGSKLRTFLGILRKFIGVTDLASVRFSLPSQLLEPTPNLEYWTYLDAPNAFVAIGTSDEPLDRMLEVIRFWLTKDLKYAKGKPCKPYNSCLGEFFRCNWETEDNAPRINTLDLQTPGSSSSSVKGAAANLKAAAKSENSSSSVSLTVPQHGTPSSEAGKLLRISYLTEQTSHHPPVSAFYVTCPEKGITARGFDQITAKFTGTSVKVLPGEHNMGIFITLEKRNNETYQLTHPAAHLGGLFRGTLSVSVSEMAYITCPDTKIKAILHYVEEGWLGRTTNKIDGVIFKYDPENDNKTRVQDVPDEDVLARLSGPWKERVVFSLGPRPMKSVPPEEQHVIIDILPLNVAPKVLPPKESMLPHESLRLWGGVTDAIHSKQFSKATELKVALEEAQREKARKREQNNETWKPVFFEHSVGNKGKPDLTDKGKQVLERAQKGDWSLEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C892</accession>
    <name>A0A2T4C892_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_291257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C892"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="149" mass="17323" checksum="0A95AC770B4F3616" modified="2018-07-18" version="1">MKEGRIIFLGRTEAAACQRCTSCDVASKKWMRRHLHRGSRTRIEARCSCVCKYQHRHLRYVWAVQSAGVQLELRYGRVSHRHTHTRWNTTADQLGQVSTISRPRGHGRAIDKPEKPSTTVSKANLFLWWLRRADDGSDDGRVRLPRRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8K3</accession>
    <name>A0A2T4C8K3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1303027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8K3"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="200" mass="22482" checksum="70536A57BD147605" modified="2018-07-18" version="1" fragment="single">MTEATNAVGAGSTLYPRYCFHLSPTANAWCLLRAAEVHALDQHAGFEGENFFFHRNLPIKWVRVVGIVVAIEQYSQRRIYAIDDSSGMNILAVVTYPAPAKPKNESTAGGRPTNNDAHTTDAQVPDPYADVDVGMVVDVKGGVSLFRNERQINVVKMVLVKGTAQEVVLWEKRTKFRREVLDVPWVLREKDVRRCRREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8L3</accession>
    <name>A0A2T4C8L3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1318479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8L3"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000110">
        <property type="entry name" value="DnaJ domain protein (AFU_orthologue AFUA_2G13210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="290" mass="32647" checksum="D55595A313AE86FC" modified="2018-07-18" version="1" fragment="single">MSDHEDVVDGEPPSIDPYEVLGLERSATADQVKSAYRKAALKNHPDKVPAEHKTKAHETFQSIAFAYAVLSDPARRKRYDTTGSTSESIVDSEGFDWSEYYREQYKDAVSEDAIKKFAAKYKHSDEEKDDLLIAYEECEGDMDQVYERVMLSDVVEDDERFRKIIDEAIETGNVPSYPAYKKENKRKRTARAKAAKAEEAEAEELAKELGVHDKIFGGKAKGKKGKGSSEDDLAALIQKRQKDREGDFFSRLEEKYGAKLKGKGKGKKRAAQEDDEEPSEEAFQAAAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C946</accession>
    <name>A0A2T4C946_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1399256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C946"/>
    <dbReference type="STRING" id="983965.A0A2T4C946"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="356"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="477" mass="53560" checksum="91818BAC52F2B64D" modified="2018-07-18" version="1">MSADGPTYLSSLQDNIRQRPVPWDGAVRAGSLTEDQYAKIRAVDKAKRAEQRNEIVSADLDGYRTLFVGGNGSPSVLEKAGKNASLVQYILVLLADLLDAVPALAKALVKSPEPYQHFLPLFRAHSNEDPIPILTAHALSTLMSSAQDDSRPTVEALPNVFTYLCGLAQSTDAGLQDLAMREYSLLLYNRVSRELFWKQRSETVTPLVNILRTAAGVGSGGDSSARLWSGTASTRPLEGSLNGGVGLQLLYHVLLVLWQTSFDAEQIGEELNDEYDIILLYTHLLRLSPKEKTTRLILGTLHNLLDKNQTTLLPTAVLARLPALLDNLSGRHLTDPDLLEDLQNLKDLLEEYTKTKTTFDEYVAEVQSGHLRWSPPHRSTIFWAENARKILEYQNGEIPRKLAEIMDKPWDNDKQVLAIACNDIGWLVKEVSEKRLQLEKFGLKRRIMELMASDDENIRYESLRALGHWLRYSFEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C955</accession>
    <name>A0A2T4C955_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1389866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C955"/>
    <dbReference type="STRING" id="983965.A0A2T4C955"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="17900" checksum="5037D08069CA9360" modified="2018-07-18" version="1">MSVMLAWVKDLVVVKNELEEGFPPSVLMTRDKPPKSWESWILLECTRRTIMIGFAIMCLVYVLKSEEAPADFWEDGHSFTASRHLWEATSSVEFFRAWREKPQYCITDMSFKEFWMYARPDDMDEFTKLMLTTQVGVDAIEHFLTGETTIPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C983</accession>
    <name>A0A2T4C983_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_253397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C983"/>
    <dbReference type="STRING" id="983965.A0A2T4C983"/>
    <dbReference type="OrthoDB" id="4798537at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="551" mass="63840" checksum="E2B4A5254E530775" modified="2018-07-18" version="1">MNRLPTELIDAILLHCVDSGPKNAVLDLRLVCKAFDRILKPYACRTLELEFSRLSKTSRLGRPRTDALQTVGYHCKSLYIDLMVLRDEMEVDFLNTVFARVPWMMEFCQLLQNLYCMGEMSFTEKEYYQAVEALLFNCRDIERLRLSLPFQLVGRHCNAATIILANTFKALASRPEEDSASMKVLVLENVTDIAVCHLWMNPSDVMNIMTTVAVLKHLVIALRRHETDPPRVGMFGSCFWNIIEHAQHLETLCIIGMEHDDRPPRGLKQTRSNQMAVEEWRARVLPPPRIMLDNLTCLELKRVEISPEVFRRFTEQFGALMEELYLNEVYLKTEQSRDWNYNSKKVLWVGIANQRPEEDDQWMAMMLRCTMPNLRICRASFLAYDLYIRDEIVTSPDFDLIDPCGIARSLSQRFVEVVMGIRQPPTPSGDPVEYLPQDSREDYLLQRLTDRPDYVRIVDYDTNAYQTAVENTTSGWQKSIDGVFTNCNPNTLDELHYIAETACQGMNEIHRRRNEWTTGNSLANEYTHNLLTAVDDPSTQLDFLTDDQLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9J7</accession>
    <name>A0A2T4C9J7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1468735</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9J7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9J7"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB78239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="16434" checksum="335949A299BBEE76" modified="2018-07-18" version="1">MSTELCPVYAPFFGAMGCTCAIVFTCLGASYGTAKSGVGIAAMGVLRPDLIVKNIVPVIMAGIIGIYGLVVSVLISDGLKQDLPLYTGFIQFGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALLMNSKASQDAVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9T1</accession>
    <name>A0A2T4C9T1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1329708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9T1"/>
    <dbReference type="OrthoDB" id="4896830at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="294" mass="31885" checksum="B0B5DDB7466F7F32" modified="2018-07-18" version="1">MEPEHISPHSGSVAHDTPAPQLPSVPDALPIAASDVSSIPRPRNRERRQSQNSLLMELLSRRMSRQTLLQQQQNQARNSQPPLTAQSLQPPMSSSSRSLVNSDWTASNSMTMEIDADETLDDDASLPSSSSQTQSIRPSRRYLPLPYIAPVAPTTNIDPAVASRVLARMRANTQPTLDSVSLPTNSSPVPAIEIDPSELVAGADMEADEGYDEGPEEFPWLGEKPSSGLTGVLRSQGLLSFTTSAEAALRCPKLVRNVPRMRKRKEKKKEHRLRASRGTAGEPSQAPAPTADAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9V8</accession>
    <name>A0A2T4C9V8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1399495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9V8"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="119"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="589" mass="64520" checksum="3DD7547F2BDAEAE6" modified="2018-07-18" version="1">MHVISWLAGLGRTESVDDYAGVLVSLEDAHLHSHSARVGRVEFEAQDDSPEDDDDDADSAKDDQGEGMLLMNAAEYTIEGLRAEMRQGKRGKWTDYEIKSKLINKAIQDIGMGRYNWHLFILCGFGWFADNLWLQGVSLTLPSLSAEFDIPEKTVRYTTSSCFIGLSLGSFLWGIGSDLVGRRIAFNMTLLITSIFGILAAYGQSWGAVCFLYGAFGFGVGGNLPVDGALFLEFLPDASSSLLTLLSVWWPIGQLVSSLVAWFFIAQWPVDIGWRYFILTIGIITFAMFCIRFFLFRMFESPKFLLNQGRQREAVAVVHGIASRNGAKTWLTSEILDLVAAEDPEQSSRVARRYSVSSAPRSSILKEKLRGLSADRLRPLFQTKTLAVATSLVWFCWATIGMGYPLFNAFLPQYLSHHDSDSGSEAMQSETSAISGVTYRNYAITSIMGVPGSLLAAYLVDHPSPFLGRRGTLASSTLVSAIFLFIFAAYGTTPTAQLIFSCIEAFAQNIMYGVLYAFTPEIFPAPVRGAGTGVASFLNRLTGLMAPILAANIPGDGSTTPIYMSAILILASFVAMCLIPIETRGAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Z1</accession>
    <name>A0A2T4C9Z1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1372910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Z1"/>
    <dbReference type="STRING" id="983965.A0A2T4C9Z1"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="105" mass="11789" checksum="38117BB350453879" modified="2018-07-18" version="1">MEPSGANKGFFQPAPILPNQFYDDVSFRRCFKLFLPFSVITEVEAEVAALGRDVLSDEVFAWITDAERNKPYLKGSGRDAFGRLQGELVTGEGWRQLQKFGLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAH1</accession>
    <name>A0A2T4CAH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1390214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAH1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="192" mass="21541" checksum="7EE74677A9FEFC95" modified="2018-07-18" version="1">MSSRIGPCMGLKPVQRLGSPTLLPQSWRKMRSPYEYKYDCGYYTLQVWHCTDTRSGRASAAPWSLFFEMILRAASRHIKASGKHYKLHIKPPSAYTHLDACLMTLTELMHAFRALHQDLVKTGDEVTVRLFLWDRGVHLGEQHEASNAMHVGCRGFDIAGNQTDVIATGRNVEITKANSSIAVLLQGPTDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAM3</accession>
    <name>A0A2T4CAM3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1197791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAM3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="8971" checksum="692F3FDD0803300D" modified="2018-07-18" version="1">MRVTKVVNRCDVCVCCALLCSQCLSRHAHKQGCKPPSFCGFQGGFESSADWLGLSPVAVRPGAGRDSPWNPPAGENLINLISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAQ4</accession>
    <name>A0A2T4CAQ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1420717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAQ4"/>
    <dbReference type="STRING" id="983965.A0A2T4CAQ4"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000049">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="548"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="857"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="882"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="896" mass="101806" checksum="19E75BB865EFACEA" modified="2018-07-18" version="1">MEGPVIPLQLKQGTLLKKVSKKNRSKLVLLSYDPETNKLLWDRARPHKFLHVDEIKEIRTGSDVQQYGRDFGIPEWERFRMFSILYAVPDKSKFKFLHLIADVTEIYQMWTTFLYDMLRHRQEVMTSLMTFNEKAINQYWQSEMQKHNSEDQEELDITGVKRICQNLHIYSSQAILEVNFRLADARGHGKLNYPEFLKFVRLMRQRHDVRQLMKSIAARPEVGLTLEEFLDFLQNVQKEDVSNRAAWEKTFTKFVRKHRNDDPSTEVSAEDFSMMSETAFIGFLSSRQNMPTIDEQQEFTLDRPMNEYFISSSHNTYLLGRQVAGQSSIEGYISALVRGCRCVEVDCWDGADGQPSVVHGRTLTSAISFQEVMTTIQKYAFVKSKFPLWISLEVHCNPTQQAIMAKIMKDTLGDMLVTEPLDPNSSKLPSPSELMERILIKVKQPRMSKDDAASGDTFNTRKRGNSLSSAIARPVNADTPALSPSQSVPQSPLLNASNPRSLKFGGKSRVNTIAEGAVQEPQANANSDTDSGSEHGSTKGSNNIVPVLGKLGVYCAGLKFSGFDAPAAKKYNHIFSFMESSFAKHARTKEEKMQLDIHNMRYLMRVYPDGSRLTSSNFDPLSYWRRGVQMAALNWQTFDLGMQVNQAMFEGGTDSSGYVLKPQELRDIQVLPYNQAVNEALAQGKKERSVVSFSIDVISAQQLMRPANLAASKSMDFYVDVDVFHANDKRNKKDRDLELCHEPDSPLLRHTEVIRENGFNPMFNNGQFRFKVTTKHPELIFVRWSVRLSSDGESYSSSSKEKLPMASYTAKLSNLRNGYRTLPLLNHAGEQYLFSTLFCKIDVDPIEKKYIDVPQTTQEGGSKLNRLGGRVFGRNSGSPRSTMEKGSAEKRSFESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB68</accession>
    <name>A0A2T4CB68_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1461811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB68"/>
    <dbReference type="STRING" id="983965.A0A2T4CB68"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15883" checksum="D410848AEC9A6F7C" modified="2018-07-18" version="1">MATLDIREDAFPARSRAASGLVNGVPTEVTLLEFSDKIMITISQDGRLAQWIQVPMMGTTAGIVDMALPSTNHGLLPSTHLAPKTLLGGGGDERETLGQLYASQIASHISLKSPEERRTLVFGFGLAKAEKEQEAFFDLFELALKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBV0</accession>
    <name>A0A2T4CBV0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1349380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBV0"/>
    <dbReference type="STRING" id="983965.A0A2T4CBV0"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="263" mass="27327" checksum="FE63615965E9705A" modified="2018-07-18" version="1">MTAADTLSLTGKTAIITGSGKENGIGAAIAHALARNGARVAVNYVSEATAPRAAKVAASIEQVAGKGSVIVIQQDVTTPEGTKKLVDEAIKGFGVDRIDILVNNAAWASREPVLTATAESIERTFKTCALGPLYLIQATVPHMPQGGRIVNVGSVASKLGIEAVYGAAKAAMDALTYSLARDLGSDGKRITINTVMPGPVLTDSLPPTAEFEMLKEGLLNLTRAERRFGTVEDIADAVLLLVNEKSRWITGECISVSGGITGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBW1</accession>
    <name>A0A2T4CBW1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1327161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBW1"/>
    <dbReference type="STRING" id="983965.A0A2T4CBW1"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB79012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="90" mass="10277" checksum="F4B192C2E7033DC8" modified="2018-07-18" version="1">MSFVPVNPRPMLQDLVDKTVLVRLKWGETEYKGRLVSIDSYMNLQLANTEEYLNEKLTGELGQVLIRCNNVLYIRGADQKDSNADVKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC94</accession>
    <name>A0A2T4CC94_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1398416</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC94"/>
    <dbReference type="STRING" id="983965.A0A2T4CC94"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="343"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB79142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="432" mass="48678" checksum="87C430B09737777E" modified="2018-07-18" version="1">MADAVLTSLCGICHINAPKYKCPRCSIATCSLACVTKHKSWSQCSGARDQTAYVAKSKLATPAGIDHDYNFLHGIEIASERAERVFVEDKGIIQKEELRPVTVDEVRWKVGRDGRRRKVLVTRVLKQNRDRLMDKLLASKLRKQGTVIVSAPQGMTRHRENHTTVSRRPGKINWQVEWFTFEEGSADSSEVHKSRALSKLLEDVPLYKGYSAVLATQAKAEGKVQRRPFRSVAQSLPDAHWHMAVDSLQDPQTGRWFTVTTPSIDEWPQAKDESQRRQFQFFLGSTRKRPDRRVIVTAIPPDGCLRDILRNTRVLEFPTIYVLREGEALPAGYVLGPKDIASQTEEQQQNRKRKGGPEQGRDNSRSAKRKRRGDEDDMEEGELGADADPDDDRSKTVDDTVVDEVIAERSLDEDEDDDTSDDETSSSGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCL6</accession>
    <name>A0A2T4CCL6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1326659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCL6"/>
    <dbReference type="STRING" id="983965.A0A2T4CCL6"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="285"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="369" mass="39214" checksum="93420B4CC532F907" modified="2018-07-18" version="1">MAASQDILSPNGGDIVDSMDQLKMDERLGPDGELAPKTDEEYAQAQLTLRAIVSSKEAGVIIGKGGKNVADLRDETGVKAGVSKVVQGVHDRVLTITGGCDAISRAYAIVARALLEGAPVVGMGGVVQNNGTHPIKLLISHNQMGTIIGRQGLKIKHIQDVSGVRMVAQKDMLPQSTERIVEVQGTPEGIQRAIWEISKCLVDDWQRGTGTVLYNPVVRTQSSGSGSLGGSGYGNGGGRDYGSPRVMRTGNGADFSNGGSRPFSRRSDSDAATRGPPTHDENGEEIQTQNISIPADMVGCIIGRGGSKISDIRKTSGARISIAKAPHDETGERMFTIMGTAKANESALFLLYENLEAEKMRRSQMQDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCZ6</accession>
    <name>A0A2T4CCZ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1389411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCZ6"/>
    <dbReference type="STRING" id="983965.A0A2T4CCZ6"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="480"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="622" mass="68177" checksum="595938A1C0E46AEF" modified="2018-07-18" version="1">MVLKEFLDSDRVNFLIWRYLLEGNYRETAAKFQKEWHVKEPQRDFEFARHVKGRALVSVVNSGLIYYALEREYARRQMPEDAAAQDESLHNGIFGPLEVQPPAKMEEDAENDEDAPGEDDDEAELSRKRNHNSLPNGSPSKRPRLDNRCESKSDAATISTPMDVDQPDDHHQDDDQSLNDNHAYPSPLEGEQVPAIVRTEGPEQGTQVDKVEQLFAGTTFIRLADDCATDTAPSPSAGSGSGSGSGSENAPILLQCEWNPTDPSILAAAGTDALARVWTISRATATDQGDHHVSPHAHALLDPEAPKTTTVTALAWMSDGSSIAVASDCGGARAAIHLWSAGGEIVQALDVSEPPVVRLLWNPSNTALLAISPENKSDTLVTVHTIATNKSLRYRLPGHSLDTGLDAAWTGDSEFLICGGDTFECLTVGETAIQRTRKFETKEDDHFAQVLFDPRSQLVATSSDKGVLDLWDESGQRRSISAHQGSITTMAWQPLPSGELAADDERLIATGGEDGAILIWNARKPESKPKCFFTMELPVVRLAFTPDGAFIAGATPRSVMIWKVDSHSLPRAVWRPSRDEFDIFRGNQDSEEEDEHCLCWDNTGQKLAYGANSRLAIISFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCZ7</accession>
    <name>A0A2T4CCZ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1169561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCZ7"/>
    <dbReference type="STRING" id="983965.A0A2T4CCZ7"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="602" mass="66711" checksum="440C46D2574A9CF8" modified="2018-07-18" version="1">MEAQALLQLPPQLLYDSASNHGSSVAGGDCFDDDFLSDAGRDSPSNADSLAEDSDDEAVPGAVSSADMARLRAMSYDRSRNLRCDCSCDCSCDCARDCDEDCGNRKPCDKACQEACEGESDRDGDGQQRRDHARPRARTRRHRHRHRHRHLQTTQVQAPDMKIDSSRTSTGGSGLDDGADGAYHPLVSILPRGTKPVRLVGEGAANAVFEIKVPPNSRVGAQFQGKLLRVAKAPSLGRAPTSSDYYFRQQEFFIREIQPHLGDHAVNQELVVLHKSGIVDELNAMLRDVNHLRKPKFQASFIGHASWGFLVEDMRPKGDDGSILIEFKPKWLLQSPSAPKSAIRCRQCALELRNYLKSPSAKAPRPERRPCPIAIANPDCPPQVSSPFRIAPQLTSLQDDKRIQTILDNIINHEALRKLRDCQKSLDDVGPLRPPTNLDFVVAMTLRDCTCFALVPANDEEGIKLRFGDFDYKDPEKKFSHWRGTEQDLIEGGFYTADWVVCGDVHYHPPSMCALEWSGPPRTGDAVILMMEEGPPKSHSRRSSCLNNDLISSLGAGKTVYRHTTDLATLHKGLEPFRRETGGAPSTSIYHNPLRCDPLTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD08</accession>
    <name>A0A2T4CD08_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U3 snoRNA associated</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1327021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD08"/>
    <dbReference type="STRING" id="983965.A0A2T4CD08"/>
    <dbReference type="OrthoDB" id="5245631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24598" checksum="460114BDA84A3D50" modified="2018-07-18" version="1">MVFGDDDDEEEVKAPAEAPSTASPAGKKVEVEEEEDSDDEAPEAVSTVKAAEDIKKSTQAAQKAVQEQAAAQKRKRQQLAELLKKQAEERKKAEESTQHQQPSAKPTEPSASRARNRADRSNIPAVLPAEFLTDSSSEDDEEDADAARASGPKRRKVSGVEKRLTRLDAGPKDEVVKSTVYRVEKKMDQRLAPKVKKHSKASKEVLLKRNRPAVTSGSGFLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD48</accession>
    <name>A0A2T4CD48_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1428844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD48"/>
    <dbReference type="STRING" id="983965.A0A2T4CD48"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="362" mass="40380" checksum="0DA163F92E5FEC1A" modified="2018-07-18" version="1">MAPTYSPPDSPLSSAMDSSEPYEEDLHDHDDETALRPSKRQKVEAGSTTSSAVVPDAEHEPVPEPDPLEGMSDVSSDTSGDIPSSPVNARLEEEDFQDQVTVCDWDGCPAGDQGNMDKLVEHIHNSHIENRQKKYTCEWRSCNRKGLPHASGYALKAHMRSHTREKPFYCYLPECDRSFTRSDALAKHMRTVHETEALRPSDPVPKSMQSGPTGRTGKLKIIIKTPQSQSAQDDGDDANGDVPPSECFTALPPDLFTEEELQIPLPKLWRKCHWEATWAEEVGDALRNECKQWEDLYYKEWLDKEVLLSQVIQSEVDWHERRQAIISGAADVQIPSSTEEREEEGTNGGAGDKPIAAGGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDL8</accession>
    <name>A0A2T4CDL8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1436874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDL8"/>
    <dbReference type="STRING" id="983965.A0A2T4CDL8"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="721"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="725"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="114750" checksum="FB184FE3D2CDFDDE" modified="2018-07-18" version="1">MGSKRKRGGKDASNAPSNSQKKAKNAASAPVPVAAPATTVAKPTLDKSPFVEAPTLEDRKREGLLYELLGSEDENDRIEAADCIISGLLGGEGVAEPVLQRHLDRRLFRGLSSGRNASRIGFSLVITEILSQLFGQKALSLEEKYSGLTFDKVLGFLLEKAKIVGNIPGQEERDIFLGQLFGLECFVKSRTLFSDPSRWNTILEELLKLSNKKVWLKSQCGWVLVQALQQMDQAQAKATLERLSNAGVAKTAEGVAVWMVALSRFPDLQVKPWQHPLARKTLGELAAILKENFNETSKDSSSNSRNNQQATWTAQLHFVWDLILNHYLQNGESEVEEFAHFWGRVVDDGLFSKQATDGQKFKGFIVFQKFLEGCIEHHPLLQILFSKNLMTSLMNQAAKEDRYLHRAAIKALKAIEGAVSSHPTALVPVLESLLSRNGVYNFDQRTSTKTVDKLLQNFNSENDKATLKTIMAPIGSLSQQEVSDAQTILRVHIDYLSKVLAACASLSAKESKTDKLKGTSLSATLQQLSRLAYSQPDDIPKDVLTEQIQELARSRLESALAKLTRQTADFVTFCQAVASIDSSAVTMSEEIKEAIEGALSRMQKLLKQKTKTDTDKTLTQGLAMLHAISIFQLYNQDPDAMEVLDDLAQFHERLQEGKLGDDTGSSEFLVEILLSMVARPSSLMRQVSQQVFEAFTSQISAGGLELLTDPLSANESAKGQKELFNTEDDDMDVDEDGSDDEDDDDVEEISNLEIDSDVEFVDLEDADGEDGDDDAEDSEEEESDDEGAKDKTNKKQKPIPVDLDDLMGQILKSHRLDKDADAESSADEGDMSDSQMFALEDKLAEVFKQRAKARPDSKKQKKDAKQSVVNFKHRILDLLDIFVRNEVLSPLGFGLLIPLLHLVRTTTTKTLASRACEIILNYQRGLKKARSAIKDKEAAANNAAEAAALPAYDADRLLSVLVEIHDEAGKDNAHAFAKAASAASLIVASAMFATDKELVKRVAAVYAKTQSDWVLGQAKLQSSFFADWNNWCQNHASQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE51</accession>
    <name>A0A2T4CE51_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1180832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE51"/>
    <dbReference type="STRING" id="983965.A0A2T4CE51"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="561"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="752" mass="83459" checksum="D160DF0CC58182F6" modified="2018-07-18" version="1">MCAYRYADRRPQPRTASYDRTAGYDRRRSPPSAYSSEEDSQQGEYSDAYSDNYDDDYDDDLQPSDSASTNHGRPQLRTRASEQPATRRQRPAPRQDASYHQQVQSYAPAAPPSVDPSEEYGHYGHYAQHPHAHQQHPAGRNSYYGRGHPAYPGQQQNHVGPYVGYNGGGQMAPYGNYGANPFSPTGSTNGSYYGGDQRHMYDMMPYGAPPPGPYYSPQHGAHYPGMPPPMMQRHLPQPPQPPPTEAPAPATPPAPKEPTPAPPPPPDPEKERLQKELADFKAEQERAEKAARQRELEEKIRKDAEDALARKMEEMRLQQEEAKREIERARAEAERAARERIEAEKKAEEDRKREHAEAMARAEESARFRFEAEIKAAEERRRREDEERARAEEAARLRLEAAIRAETAAKAAAEKKAAEEAARIEEATRLRIEAAMKAEAEAKAAQAKREAEEAARIEEAARLRVEAALKAEADAKAAAAQKAAEEAERLRLIQEEAKAKAEAEHRAKLEAEREAAQKAAEAAAAAKKEAEELKKKIQEETRAAMEENTRKAEEAAKKAELAPIKFKDAVGRKFSFPFHLCNTWQGMEELIKQAFLQVDVLGPHVQEGHYDLIGPNGDIILPSVWEKVIEPDWAITMTMWPLDKAPPVGGPKLPPGMPPMPKHDQMPPGMPPLNRPRPGAGMPQMPQMPPPPPGWHGGPPPVSRGPPTVPPGIKIVNAAPPKKKSSSSSSKQSTTMLNFLSGKPVKKKSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE60</accession>
    <name>A0A2T4CE60_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_173420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE60"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="9393" checksum="1F691B096D8615FC" modified="2018-07-18" version="1">MQLASSVSSYMPLAISYTTPVFHFLPQSLMMACCCFCSAETHQVQLAVLLKSSLVIQAVWVSLKRPKRFGKWSDVRGDKVRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEB0</accession>
    <name>A0A2T4CEB0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1325611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEB0"/>
    <dbReference type="STRING" id="983965.A0A2T4CEB0"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="10">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="12246" checksum="3D0AEA808447CD2A" modified="2018-07-18" version="1">MSLAAYRNLLRAARIAFQGDVHVLSAAQAQIRQGFQENRSLDSSSSIESAIKHAEDVATILRQNVVQGRKVEDKGDDYTYKLRIHEHTERGDNDSILTAGNAKSASGGGCGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEC5</accession>
    <name>A0A2T4CEC5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1691-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEC5"/>
    <dbReference type="STRING" id="983965.A0A2T4CEC5"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="2">
        <location>
            <begin position="117"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="252" mass="27365" checksum="CECE5DC5B0B913E9" modified="2018-07-18" version="1">MSVFTTMHLANVSLIPAVTRSVAGSETYLLMARELYQTAVTEPLLVGLPVLAHIGSGIALRLLRRSENIRRYGGSTPGMYAMLRSRKDATGASSRSSVQLWPPLSWISWSGYVFTAFWGAHVCINRVLPLVVDGDSSNIGLAYVSHGFARHPLVASFAYRGLIGVGCGHMVWGLAKWFGIAPSTKGWWGSEAVTVDRKTKRQRRRRWLAIQAAVVAAAALWAVGGLGVVARAGPVDGWVGKLYDDLFARVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEF2</accession>
    <name>A0A2T4CEF2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1325675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEF2"/>
    <dbReference type="STRING" id="983965.A0A2T4CEF2"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF24">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="521" mass="58446" checksum="A32414A361BF993F" modified="2018-07-18" version="1">MSNRAAQACDGCRVRKVKCNSNQPCSQCSHLGLGCIYSPSTKRKPSVRNRLVTQLRNNELGAGRGSINNVGADGAGYRAGFPTEPASGTHAFPAGFFIGMLPKYEEQVYPVSPIITSYEVRESIDNMHVSLDDAAFVYATGAVTINLTTPTVHGEAGAKMTELIRLGLSAYRRAESVSDVKNGRLTEVRTTFKRIMTCIFLEVSMMAFNRFDRSFATLREAMTMVQMIHVQQCSHNAMPLEPRDLPKFQRVYWEVFIHERFLTILSGFPCIMAPLPTGLPVRDTSIPAHIDVGFNRLIRLFQIMDGPFLLYWNAQQNPAQPVPGVSLQWIESKQAQLDEDEIGASEAEQALIESGRGSFTELQHVDLFVTRLWMRTLLWQFGLTHGFLRSTPSQNVHEGLSIHFPAHRLSVQLRALVSQLENVSTIVTHGMGLLQKIFEITSTVADVLALPLGYGQTQEDVRSRIEDFAFLVKFLFSFERAEKDQRDYLRHKLEVLQQQYTMVNFAGIVGLSPTVHAPYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CET9</accession>
    <name>A0A2T4CET9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1324448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CET9"/>
    <dbReference type="STRING" id="983965.A0A2T4CET9"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="503" mass="55181" checksum="D9F31FE984622CC1" modified="2018-07-18" version="1">MAEDRHRQEYPQQQRPEDIKQHQALPSYYHHVPPRDAPPSDTESSAHSRSTMATSVTLPSIHDSRPSGYGPPLPAGRGYVSDPRYASPNAVNGYPPPPGSQQQPAAYLPPLQPQSDPRAAYPPPEPRGAYYDDRRPPPHPAYHDQYSTDYYYRGLPQAHHNGYAHDYARPPPGYAPDYGQPGMDRPREAPRQRTSIACRYCRKRKIRCSGHQNAPGGKCQNCARMNQECIFQPVSSSSSTAFIPVSAVPGGVPPGTQLFGAYGQPLAPSTVPHPHPHPHPHPHHPQHHPQHPSHPYPPPAGPPHPPPGPYYHPPAQSPTDSYSSYGDPRGDPRGDMRGDPRGDPRGDFRGEVRADDQKVGRRRRRSSQDLDDAYRLPPPRGGGLEDDHRRRSPAELSNNSSPGSLSYSRYPTAIRHSPRNPALPHPSSVGTADGRSPITQQNGSSGSSTPARSGPSAGQSQQSNSVMSLSNLVDKNDIDKTMIERLNRPRDAGSAQSQREPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF04</accession>
    <name>A0A2T4CF04_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1113517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF04"/>
    <dbReference type="STRING" id="983965.A0A2T4CF04"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41047" checksum="6F30CDEA4EE904E1" modified="2018-07-18" version="1">MGDTDFDIDFYGDAEGDANDQANDQSRQDERRHSGGDSRDDYDYHSRDSRQRDNGHEDDRRYESGRSEDVEEPPQHQQQRHQQHHQQQQQHHGVKRKSEEQEHNDRPIDNGATAAIMISELNWWTTDDDIRGWLRKANCEREVKELTFSEHKVNGKSKGLSCFVLLSQAYVEFHTRQASTAAKRYIDTIASDGVQPGQKKMTISYWNPGVNPFRTLPKDAPARVKEQPRAAPSGSYSDRGNYGGFRGRGGMGGNRGGMNPNFNRGYGGNMGYNNNNMGGGGFNGPMGRPGGGTHYVFSGQSSPGGPMRGVQTIIRGRGGGGAGGGMMGMNPMGGMGMGMPGNMGMGMMGNGMPGTQTLHTLPIPKTPPLQVVPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFJ5</accession>
    <name>A0A2T4CFJ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_189869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFJ5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="234" mass="26571" checksum="E39B8CDF79487C8F" modified="2018-07-18" version="1">MSRCYENYKTANLLGCHQIALSPGDCYSRYTCSSTPIGLLLFSHILCTILAMNARLSFSHPPLPPAIPSHFVLLLPSFIPPGTQRRATTHYCSPSRNHEIVPGNYHNRPGPPLSISDRNLMKSTPQPSIRTENAICSTLSNRRKEKGKKSEVFFLSSSQFFVLFCLLLLLFLFLPLDNRKNQEYQSRKAVVCDPRISAAQLGVNGFSSRKSRTREYPSFAGKVSLRRWYFLHTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFK0</accession>
    <name>A0A2T4CFK0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1388644</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFK0"/>
    <dbReference type="STRING" id="983965.A0A2T4CFK0"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="104"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="219" mass="23858" checksum="2508069B7C3392FA" modified="2018-07-18" version="1">MAGKKGLENSKKAAGNARKAETAAKKSAAADAACETAEGEKWQQGAKNTSKKEAEAAKKAEAAAKKAEKEALMKEEEASLNARAEPKKSKTAVKKSRGLDLSQLEGDKLGTLSASGIDNALDALSLTTGGDDSKIDQHPERRFAAAYHRYEERRLAEMKADGSGTGLRLEQRKQRIRKEFDKSPENPFNQVTASYNASRDEIKDIKSQELNKIEKRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGB0</accession>
    <name>A0A2T4CGB0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gated mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1436163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGB0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGB0"/>
    <dbReference type="OrthoDB" id="10010920at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.120:FF:000004">
        <property type="entry name" value="Ion channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="entry name" value="Large-conductance mechanosensitive channel, MscL, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266:SF2">
        <property type="entry name" value="LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="MECHANOSENSITIVE CHANNEL MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="Gated mechanosensitive channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="200" mass="22042" checksum="2CB999D156D06CF6" modified="2018-07-18" version="1">MPSRDVEYGGPSETHSLLDKGRTKVTRFFHGFVDFAFQGNILQLAFGLILAAAFTDLVKSFVSAILMPPISVILPINKNIEEKFAVLRPGPHYNASAPNGGYNTLHQAQADGAVVMAYGSFVYQMVSFVMVGFSLYGLAHVYELVGTDPIIKYSKKCPYCLKRINEKSRRCINCSSWLDGREDVDAINPASTSTFSSQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGC4</accession>
    <name>A0A2T4CGC4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1320355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGC4"/>
    <dbReference type="STRING" id="983965.A0A2T4CGC4"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="260" mass="29252" checksum="B6604190264781D5" modified="2018-07-18" version="1" fragment="single">ISDICTDLRQNTGQGKALMLLIEKYGLFGAWANPASFETGLSSKESLEQLIGKGAFKPLDLQALMHGASQNKFSTKDKRALAVKLGFCLMDFFDAEITSRRIYFWDVSRSGPKKEFPYLSFDSKLPATADPYNFRMGHPALLSFAKLLLEIDFGQAIELAISPDSSRNQATWATLVSLVDRLEEDRSDSYLQAIRGCLNVHRKLAERLRSRDLDEKGAELRVRKTLYKEVVQKLELGLAESIPRPAHKRQRSESPPPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGC6</accession>
    <name>A0A2T4CGC6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1369920</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGC6"/>
    <dbReference type="STRING" id="983965.A0A2T4CGC6"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB80593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="72" mass="8317" checksum="752725A29662DEA0" modified="2018-07-18" version="1">MESPHEHQQNLLLSRIITNVEKLNEAIVVMNKSLQEINVQNMNVELVAQMFKNYQSNVLFHLEATDNLKPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGD3</accession>
    <name>A0A2T4CGD3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUR7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGD3"/>
    <dbReference type="STRING" id="983965.A0A2T4CGD3"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34003" checksum="11B9C8ECD7E3DB6F" modified="2018-07-18" version="1">MSALLRFAVLIPLIFSLVAFVLTNLALFAGHQKGFMEEYAVIRLNTSMLGQNMFQSDDSSDSSSSDDDDGDSLWDKITDKVDDIKDDVKGKISDIIGDIADDLADELGINDWYSLHIMNACMGSFGPNATTSHYKLNTTNCTSSSPANRFNLTEILDHQLSIGPLDLNLADIHWPGGIQSSIDTLNAALLALFVFYVLGVGFSGLAMLACVPAFLLQDKRLVLMVNSALALLAAATITLGSIIATAASAVAVSAINDKGEPVTLVATQGSKFYGLTWAAAALMIVSALFWVGKFAWLWKREKRERERYSKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHK4</accession>
    <name>A0A2T4CHK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1322999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHK4"/>
    <dbReference type="STRING" id="983965.A0A2T4CHK4"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="546" mass="59471" checksum="B7516A2A7A24CB14" modified="2018-07-18" version="1">MTSSEKTSPPSSPASKGMSNLTPSVPDEEANKYMAEPAGVVYRSISHVSGPDVLESSAPQEPQQSSGPYIEAGEEIYDRVSSRRKHVIVSVLSFCAFLAPLSSTSILAAVPEVAKTYHTTGSIVNVSNAAYMALMGISPVVWGPMSQVFGRRPMTLLTTVLFFLLSIATALAPNLASFFIFRALSAFEGTAFILLGASCIGDIYRPTERATALGWFMSGTLIGPALGPCIGGILVTYTSWRSIFWLQTALAGTGSLGVFFLVPETIHRKRIDDLEGCSRKEKAKAILHMTSPIRVMRLFRYWNQVLVALASSALVWNMYSLLTPIPYVLNPRFHLESPMLSGLFYLAPGSGYLLGTFMGGRWADRTVKEWIKRRNGVRVPEDRLRSAIPFMAFVVPSCILIYGWAIDKAVGGIPVPVIMLFLQGVGQLFCFPALNTYCLDVMPGRGAEVTAANYFVRYMAGCVGTAIVLPAIEGIGVGWFETISASLVLLSTVGVLATIRWGKDWREKIDAQKDSSVEDDAGEVTEVDDRQREDKAADREKPKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHQ3</accession>
    <name>A0A2T4CHQ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1007722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHQ3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="183" mass="20275" checksum="AFDABB1EC914947D" modified="2018-07-18" version="1">MKIGWDAASSQAAAKPVSLRCIRELPIEWVAFGIRRSAWHFCDQSPRFEPLGCIPSISCSFFNPVSKRDAFARCHDSSSTQYQCPKHHSIQHAVVKDRRPAICLFRLFVFSNIGPLSSQANIGSKTLCQRGPGKIKRPTYTTRCSRAIPHQSGWITGCMQLQCVSARAPRSAGITVATLLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHY2</accession>
    <name>A0A2T4CHY2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1345725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHY2"/>
    <dbReference type="STRING" id="983965.A0A2T4CHY2"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000032">
        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="253" mass="28958" checksum="C728C3B7F94CB970" modified="2018-07-18" version="1">MADPFEVRMRFSSQLQHLNASVASAQKAAQYALKYKDMDEDLHSCILEQVERNNMNTRANIMYFIEHFLDLAQRDGHSDYIRMMQRDIIRVVDAVAPDDGSGAANVKVVRKVLTGLQNKGFLEHQVVAQIEDVIKERGTNDDDLGLASPNSDVDMTDAPGSESKSRRRPAAHGLDKRQVEQRIEEDRERHKRERERIWAVPKGEDAEMTKLWEETSDFGDDDDRLLTEEGDDFTKEMEMQQCSHQQPTNGNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIC1</accession>
    <name>A0A2T4CIC1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1396457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIC1"/>
    <dbReference type="STRING" id="983965.A0A2T4CIC1"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="593" mass="65411" checksum="4AA3B4FA607792DF" modified="2018-07-18" version="1">MSQQTHHIGQRISYDGAACTVRFIGGVAGTTGTWLGVEWDDAARGKHDGSHKGTRYFTCISKSPTAASFVRPTRPADPPQSFLSALHERYVADAPGQTQGRSKTEIVISGKVAQEMGFDKIWRRQSRLREMKIVVLDGLRVASARDGGDVRDDGSGELKTIEDTAPKIVELDLSRNLFERLAPVVEICRDLKDLQKLAINGNRFQDVLTDEALQGAESVFGGLTELQLGETLLSWQELCLIASKCPSLTTLLVGSNQLSTLPPTGEISLPSTLTSINLEYNDFTSLSDIAYLTSLNALRHLQLKGNNISAITASPDSPPVVFPPSVQYVDLSYNKIDSWDFVDKLAAVFPGMTGLRITHNPIYYSIDADSNAQSSDESFMFTVARIAQLKTLNFTHVSAMDRTNAEMFYLSRIAKQLATVPEAAEESIKALHPRYKELCEAYGEPDVIRREEINPNFLEARLVTCEFHYEKAPEGSKKTRTVRIPKAFDIYAVKGIVGKMYGLKPLKLRLIWETGEWDPVAGYDEKDGDDDVSDDDEEMVDVDGDGQAEAGGEADDQAGRWVKREVELTDGPKQLGYCVDGLRARIRVEASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CII4</accession>
    <name>A0A2T4CII4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1322392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CII4"/>
    <dbReference type="STRING" id="983965.A0A2T4CII4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="365"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1102" mass="124344" checksum="702AF1EE2C435548" modified="2018-07-18" version="1">MADLDPRLYTVAWIAPLEIEARAALHMLDNRHPGRFPSKRGNDYIFHAGDACGHNIIIATLPAGDLYGTGSAAALANQVKNFFPNLWFGLLVGVAAGLPNLSRCPALDIRLGDVLVGLPIGDNAGLIPYDLGKETGSHGIQLLRAGHGLARTEAVVRSAIGSIKLMAPNDADEILHLVQREPRPASKRTRIWYGSIGSGEKLMKNAQKRNELRDKYDLIGLEMEAAGTMDRIPVGVIRGVCDYGDEHKNKEWQPYAAAMAAAYARAILAKIGPIAGTEMDLSRKRNIDADESVSTMGHERNKRPYRETRDGPASGDSRIESDREQPVPEPFHTMDARTKVSLLEQLYFDKIDDRLMNLTAAQGKTCYWFLDKPEYKSWNDPSRQPKHGGFLWIAGNPGTGKSTLMKFLFEKEKGHAKAKPSQIILSFFFLARGAIEEKSTTGLYRSLLHQLFQKAPETQNGLDWMTADGAKILQRNGWNEQALKQTLKEAVQQLGHRSLTIFVDALDECNRDQVAGMVCFFEELCDRAQDSKVWLQVCFSSRYYPIVVIRRGLEVRLEKEIGHTEDIEHYIKSTLWLGKSKQADLLRSEILNKSSGIFLWVVLVLRILNQEYPNRSVPIKRMSDRLKEIPPELNNLFELILTRDDDDLEQVHICLRWILFAAHPLKSEVLYFAVQFGSETGCTGYWDREEIGLDEMKSFVTSSSRGLAEITRNKASEVQFIHESVRDFLQNKYETEWYETSANFAGNSHIILRDCCWAQLGCLVPESIGIEDPLPRAAALTEARGKVNSEYPFLEYAALNLLHHADCAQHNGIEQRDFLDTFSLAKWILFNNFLEKHQIRRYTKSVSLLYILAERNLARLIRDHRRAASCFDVEPGDERYGTPIFAALATGSREAVWALLRKETEMMHSDSPLHNLRESYCQDRKRRTKLGRDFVFSRRKGMLSYLVEEDETLLASFLLTSGLLCETSGIWLNHQDRNGQTPLSLASQRGYETVVKLLLEKDGIDVHLADYQGRTPLSLASQLGHETVVKLLLEKDGIGVHLADYQGRTPLSLANAGGHANVVDLLQKYELLQPDHWGFDFLWPNGLGSQSNDFNDTESYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIN7</accession>
    <name>A0A2T4CIN7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1367383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIN7"/>
    <dbReference type="STRING" id="983965.A0A2T4CIN7"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="435" mass="50340" checksum="62F37DD8992081F3" modified="2018-07-18" version="1">MHQYDNQPLPKRRSQRLIEAKASKGEAFQSLESITDPTIMSFPTEVLLLVISFLDIPSRLSLGLTCKSLAELTLDESKSDLTWQDQVEFLSTLQRDIPYTYFSYNYAKLYPLDPNLDWRSQPHAKASCFFNNYLWLPVIKRSDHMKLPRRFHLILDRTQISFMEVNLVMSRHFYGFSHGISLQTLERYEAFEDVLDLDQCLWLRNFKLSRPFKFVAKRKPRIGIRLSKRSLEAVPRAKNAWRVSFRYTAKIVDDKLYLARFYTIVGPHVSVEHFNRLINSIGIPICNHLYCSANTSCCSRYDGVQMNYLRYYPRIKTTLPSSYFGDGPEFKLDPKQDSCVVCSTDYDVSVSRKTDNHETSLSISVYHCLGSCRSPNDKLWAYFASDSPPPLSLGADAAAVFRNNISCRVQKLKSRTPELDRGGPRRKWHEAACLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ09</accession>
    <name>A0A2T4CJ09_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1396682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ09"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ09"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="203"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="306" mass="33694" checksum="D19C3C9C55F2E398" modified="2018-07-18" version="1">MASRMSTSLRLANRTLGKSVSTTRATSCSSPLCGPRVLRQQRFYSSEQPRSGGGGDRIKFWPFLALIGLGTAAYIQLANTRVKNKDMPPTNELPAPAAQLSQTKPVFDPADVTVVFVLGGPGAGKGTQCARLVAEQGFTHLSAGDLLREEQNRPGSQFGQLIKDYIKDGLIVPMEVTIKLLENAMTEALRQKGTTKGRFLIDGFPRKMDQAHKFEEAVCPAKLVLFFDCPEKVMEERLLERGKTSGRTDDNAESIRKRFRTFVETSMPVVDYYESQGKVIKVDATPAPEDVFKTTNKLLTEKLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ79</accession>
    <name>A0A2T4CJ79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ79"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ79"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
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        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
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        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1257" mass="136445" checksum="17B3B576D0BFCDC4" modified="2018-07-18" version="1">MSFNYSRRAEPVNGSRLSSRTGRASYRADDWEDWEDDDVDSDKKKLLLSGTYLNTSASSSAVNTRSPSPLDSDSVSISSNEDITPIDSAVEPGLLAPPPTPAYILTSATKPINARISARRSAANRPVSKKPLKARNAKRQFQAKSPARRAPKFGSPNPQSQREAASPLQSARSPAEQLSPEDRPIVTSRGIDPLTATVNNIDTPSGTKNPFPFTFKTTNERANERAVAPSVEPRQLQSVWSPDTPETASSFSTIRYPSSVYSQASMAPAMGLGLRDNEVPPVPAVPANYQGMTPAPQRIERLKNAQEEEESGTPCTLFEEDGVTPLKSPASKLSALTPQSVRGWWDHHLVTPFLDRTMSFASRRTQLESPMEERGHHLARAADKGDQSSLLTPKLAANRQSWKSAVSGAEGGQTPSPMESQRSQTDSPAANVDGGRAILGLSMLEKQRDSSASSSAVNLPRDGQGLGGPSHVAGIEHSDIHITFTADDDKSPVKRGAADVSADYSSRTGHYLQTSSESHEATSLETSTSKEVHGYNFTSSSVEVREHHTHSTESQRKYEPTREAKRDLTPPPRPQWKEAQAPIIRVPTPRQTPPPREVVREVSERPIVVHIHVNTGEQQQQQQQQQRLLVDRVAVNSTPTIKIPTPRRTPSPLGQVSRDDAVPEVTRGALERNGSASRERVQGLGITNLATTTPPPASSSKKQAGNGDAVKYQAVFPPDHHFNSQFSPREAPLATSTMSTKAREAAPSSSSPTVSPVSPVAPPFAATTKRAAATAAATSDRLESATLTRSTASNSRATTQETSVAATTALSGASILSSHDSYREQARTLTREVQDDAREASTSFRTGNTDFSRNVEAASSNTSRTAGLQRQASTVAHAHHVSEQQSRFSVSPTSSKSPDAERGSRAPRHVRAASNFVSSVLSRQRSPVDQSRGGDNRGVQPIEIVLEEQRAPETMPASPQRAYLTFSADHERGSWTRAGSLDMERGHPEPLPHRPAGTSHSHAHADQLSGMEHKIERTRQRHEKEDRAARRAGGLWRGRGCIPKKGCFGRPGPEGRKKRRIWLLIILLLLLLIRHSNWLLPPRTGPRSQNSGKLGTTDESCCGAVRALRAVNDSSQGNVPADEDGGCSETEANHLVTWAETRMLVQIWTRKLNSTASLLEGDDDEHIDDSTELIKPGTMPYPVTVTLDTHGGDPDHKVVWEWPMDDRQKLNTSAPELLANKMDVGGTWINHRGSGNAKFGGFDGGTGGCKCQWVNWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJC4</accession>
    <name>A0A2T4CJC4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tricalbin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1346620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CJC4"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="230"/>
            <end position="435"/>
        </location>
    </feature>
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        <location>
            <begin position="431"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="574"/>
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        </location>
    </feature>
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            <begin position="700"/>
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        </location>
    </feature>
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            <begin position="1081"/>
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        </location>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="868"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1303"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1464"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1487"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB81612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1500" mass="165698" checksum="57D79DF49CFC49DF" modified="2018-07-18" version="1">MSAKEVHELKVQGAIEAAQDPQTSVSPEDAERLMVNEARDAGAPAFIFDPNASVEEKRAQVAAAIPPELQQIRRNKATAIATDIDDGTGPDEELPEPTKEGALDDAGKDKPLANGDAENAEAPYSRTGWAPQVGWPVESTLEGESLLDHTTWVESQLPDNLFGDWYHNAGVIVFACIASWLVAVLGGGLGWVIMVMAICGTYYRTSLRRVRRNFRDDITREMALKRLESDHESLEWINSFLVKFWPIYQPVLAETVINAVDQVLSSATPSFLDSLKLKTFTLGSKPPRMEHVKTYPNVGDDIVRMDWKFSFTPNDTADMTARQLKNKVNPKVVLEIRVGKAMISKGLDVIVENMAFSGIMRLNIKLQIPFPHVEKIEMCFLEKPTIDYVCKPLGGEHLGFDINFIPGLEKFILEQIHGNLAPMMYAPHVFPIEVAKMLAGSPVDQAIGVLVVTLHGAHNLKNTDNFAGTVDPYAVLTLNRRQELARTKTVDDNPNPRWNETHYIIVTSFNDTLDIQVFDKNGFRKSKELGVASFPLERIEELHVYENERLEVLAAGKARGVVSCDLRFFPVLEGQKGEDGKVEPPPVSNQGILRFTVEQAKDLDGTKSLVGQLNPYAVMFLNGKVIHQTKKLKRTNNPIWDNGSKEIFITDRKRAKLGVTVKDDRDLSSDLTLGKYQIKLDDLLECMEQGKEWYHLAGAQTGRVKMTAQWKPVAISGVAGTGGYITPIGVMRLHFKKANDLRNFEAFGKSDPYVRVILSGIDKARTVTFKNDLNPEWDEVLYVPVHSARDRLTLEVMDEEKLGKDRSLGLCEVSAADYIQQDETGEYLVHDEKRVHESELRLHGKGLPKGTLTYTVAFYPCLNIADPEEEEEEAAEEAANAEADGDEPKASLDRPRSSASPSIPKASLDVSRKSVDVSRKSVDTAKLSASTGEDGRPISPASMRSSMSVEKRGPPKIRLSPEELLRYESGVLIFRLLESEMPEKESHLEIFVDDMAYPSYTSTMVPTKSHKFDEIGDCVIRELDFSRLTIKARKKGDDADDTLAYLSGNTLETLKQCLNNPTTLKLKSDDGKSSWVKVSLKYIPLKMELDPSESINNMGTLRVDVLSGTDLPSADRNGKSDPYCKFELNDVEVYKTKVQKKTLSPVWNEFFEVTVPSRTAAHFVCNVYDYDFADKPDFLGAAVIPLDTLQPFKALEQSYPLDGKSGSIRLRMLFRPDYITRSRQGTSTFQGTFGGTGRIVTGVAGVPFKGGAAVAGAVGHGVGKGASFLKRGILGKKDSHDPNGSLTELVEVPTVPSIVTNGNDFAVGGSHSRPTTSAVDSSRDYPPHLMPEGSGHNRTRSFGSSSVHSAVGIGAPTGTATFNVIGASGYPHSTDLYILITQISPREKTVGKTKHHKTSSGQWTFDETFRFNCTPDAQFKVEARGEHMFGSDDHLGEHIYFVDETGSGAPKEITVGSGTVTIKSHFQPTEDKYPDSPKSFSRRGFLSKRESRSRDPSVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJG8</accession>
    <name>A0A2T4CJG8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1022195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CJG8"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="3">
        <location>
            <begin position="203"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="629"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="881"/>
            <end position="966"/>
        </location>
    </feature>
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            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
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        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
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            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="980" mass="109878" checksum="29DB95E8C46A9413" modified="2018-07-18" version="1">MLPTESLAWIGFQALKVRLAGRLAAFTHRKPIANRPTRVQNDADLLDCDLRDVFKTATLDVDLSVADFEDLDHRAHDLLSSLDRMVNEDYTQGHTEDDREHYYTDSHDIRKIGTVYPNLAALMLFLDESDSRHFNLASDPSSSLFIPAYGETRIQALNHVAAWRTSLQKLASRTEQSQGWDGIVQRQTSIGATKPERSRLPVAQNPVGVVMDAIFKEFEQVNCGMAHEVKLRVLDELHAAGSHWPKIEMLISCCQAECDWQEAICDSIQAPTNLEKKNNICIAIHESWKQRTKLRLFFDQRGLFDITDEEPPIASSIQDYEEEALNSLLDKDVFRPISPGAYLRGLAIERFDHREKTSLALALARCLMVFFDKSLERAVCNWNAESIFVMRSARRQGEPPWWHILVRSHPPNSAHHNLHDKIGPGNPVLLSFAKLLLEIVNGEKIQLDVDPQNVARNIGNWAQMCGYVEEARQDRNSFYLQAVQGCLYLHMHLQQGLHEQNSLSGTAMREVIYEQIVRNLEKELHPEGLKRKRRESFSDTPPSKKPYSMEPLGLDECVAGELTMQQSKSTMGVPSLLRGTNNRAPPRGVPRSTSSFSSYKSSEVLSKSLFHSTMTTTTVIPPDRDHFSVAIICAIATEYNAVCHIFDEFWDEEGDQFGRAAGDLNTYTTGRIGKHNVVLALLPQMGKSNAAAAAAGFRSSYNNIELVLLVGVCGGVPRVGGCIDDEILLGDVIIGKAVVQHDFGRKYPSGFVRKASFEENLSKAPKNIQGLLNTFETDRGLGLLERQTARFLLQMQNTGKGRNRRPLGKYRYPGTAKDRLFRSDYRHKHRGSRAPLCTICSSSDDAVCEEALSATCEELECEESSCIVRERLQEKEDIEQNSQEEAQKPAIHIGAVASGDTVLKSGEDRDRMAKKEGVIAFEMEGAGIWEEIPCIIVKGVCDYADAHKNKRWQDFAAATAAAAAKALLHRYPKTEKARYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJH8</accession>
    <name>A0A2T4CJH8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_44104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJH8"/>
    <dbReference type="STRING" id="983965.A0A2T4CJH8"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="375"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="656" mass="73252" checksum="FB7ADF9FCA9000ED" modified="2018-07-18" version="1" fragment="single">MNGEKEEPIAIELTQSQYIVGWVCALTEELAAATAMLDNVHLIPIDLNLPSTDDNVYFFGSVGKHNVVVTGLPKGKIGTVSAAVTARTLVGSFPSIKFGFMIGIGGGVPSEDHDIRLGDVVVSSPVRNFPGVVQWDLGKAMDGGTLERTGALNSPPRALLAALTHLESTHEREDSSIPGYLEDLKAKAQKLMRSYGKPDILSDILFSADSPHRNNGSGRGRPGCEACDAAKIIQREDRDEPVTIHYGLIASGNQVIKDADLRDRLNAEFGGQVLCVEMEAAGLMESFPCIVIRGICDYADSHKNKKWQKYAALVAAAYAKELLMVGSQHKAILDWLTPVSYDSQQHSIFNRRQQGTCQWFLQSKEFRQFLQKDSRIMFCEGFPGTGKTILASIVVNYLQHDLGSPPEEKVGLAFVFGDFLQRSHQRPVDILASLTKQLLRDQAYVPQEITETYNKSREISAPSRSHNDNPTFSKMLQQVIISLFTRVFIVIDALDELDEAPSVLREVFNFLEGTSASLFVTSRPNEKIQRMIKCDFEDNSPFKIRAQAEDIELYMDERLSHLKLFSHEVTDYSQETKSQLKIEIKRKVSEVVDGIFLLAKFHIDALEGQTTPRKIREKLETLYQGPDAYAQAYKKTIDRINSQRPELRLLAKRALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJN9</accession>
    <name>A0A2T4CJN9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJN9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJN9"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF51">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="375" mass="41425" checksum="9ED24D500E0473F5" modified="2018-07-18" version="1">MDGTDRDRQTFGPLLDITEEALIRLASIIANDSLKTFPSSGGKLLARIDGSYNIVHIVDVVSTQLVIRVPCTGWGSGMTPTAAQAMESQVATMQLIRNRTSIPVPEIYAFDTTANNEIGAPYLCMSFLPGRPVSQLWFGDSGALRLEKLRLRILTSVSQAMAQLSCLEFGTMGALMEEDSGAAVVGPLYDCDEQEDGSIKFTSLGPYISTSAFLEQKYITKSQDNVWGTAKRRAMEAIIACRPTFDSPPGFVLCPPDFDSQNILVDDQGTVTGFIDWDFAHTMPRSIGFARYPGWITRDWDPLMYGWPHMPDSEDSPETLQRYRAHYNAEMGKALQWQGDWSLTEKSHIAEAIWIAMLHPISHGDLSQVCSGCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJT6</accession>
    <name>A0A2T4CJT6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomethylpyrimidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1025217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJT6"/>
    <dbReference type="STRING" id="983965.A0A2T4CJT6"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="295"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55013" checksum="ED4BD207E182E5EA" modified="2018-07-18" version="1">MVNGKVLVIAGSDPSGGAGLEADQKVLAAHGCYAMTSTTALTIQNTKGVTGVHVIPSEVVGKQIEACLEDIGADVIKTGMLASAETIQVIAQMITKFKVPALVMVSTSGAQLLPHEAIAQLTQHLLPHTTVLTPNIPEATLLLSQNGYETGDIQSVADVEAMGRKIQELGPKWVLVKGGHMPFKSDFTVAKTKEEKEVVIDVLIGPEGTVVRIESPYQESTSTHGTGCSLASAISARLSQGADVPTAVRGACRYIEAGIKTAPKIGNGHGPLDHFHSTHILPFSPGYFIEYLLEHPAVRDVWNEFLYHPFVMALGNGTLPLESFKGYIVQDYLYLIHFSRANALAAYKAKSIGDISRSNEIIAHILHEMKLHINYCNSFGISKPEIEATEELQACTAYTRYVLDVGQSEDWLALQMALAPCLLGYGAVAKMLHAHADTVREGNTYWAWIENYKADDYVEAVRLGSELIEKNIRLQSPSRIEELIKIFAHATRMEIGFWEMFPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK41</accession>
    <name>A0A2T4CK41_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1467288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK41"/>
    <dbReference type="STRING" id="983965.A0A2T4CK41"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="33351" checksum="272915BE837E7AE5" modified="2018-07-18" version="1">MAPQVFLVTGSTSGIGAALVEHILARGDKVIATGRNVEEKLGHVKAKSENVALLELEVTAGIEEIKAKIETAWNIFGHIDVVMNNAGMSAMTAIEDANDAYVQNMFSVNLFGPVHITQAILPLFRAQGHGCIAFTSSSSSWMALPTMSHYSMTKAALSAFAECLHKEVSDLGIRSVAFDCGGFITNLMQPREGAHASPAGAEPSDAYKPLFGNIIGMFSNDPMSLMPGSPDRAASTMVDVIKREGVAAGRPWAARVVLGSDAYDSALNRRQEELKLLKAWQPVSASTDEHKFEPREDFRRVSRMTGVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK61</accession>
    <name>A0A2T4CK61_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1322871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK61"/>
    <dbReference type="STRING" id="983965.A0A2T4CK61"/>
    <dbReference type="OrthoDB" id="4941282at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="219" mass="24085" checksum="1A5BFB8AE1C1040C" modified="2018-07-18" version="1">MPSDEVDAATDLTDPSLLDEEEMPEEGQAPANKKAAGQPYALGGGGYNALKTFNGQYYSGMAIGGSHTWNYDGGVWHETKEEPDLWKIDYKTNKRRAKKAPANSGAPVGTEYHWLIVAHQHVRKIDANTYETHLEGSKYKLAHKGATSKSWSIPTVKGQRERELELLEDAKRRVQGLPPVLGSEKVKVKTAEKGQQKLEDLFSKGNVGGGGGKRKRDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP31</accession>
    <name>A0A2T4BP31_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1038935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679226">
        <property type="protein sequence ID" value="PTB71051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP31"/>
    <dbReference type="STRING" id="983965.A0A2T4BP31"/>
    <dbReference type="OrthoDB" id="3434013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="98" mass="10089" checksum="32B53FBA271F657C" modified="2018-07-18" version="1">MTATAASKQAEEAPMSLFDLSRATASVASRNFTKLSSLSSSLAGAASLASSMTSDASGEQAPQRPRKRDQLREAATGTLVSGVGWLIGANVNREATET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP48</accession>
    <name>A0A2T4BP48_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1366382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP48"/>
    <dbReference type="STRING" id="983965.A0A2T4BP48"/>
    <dbReference type="OrthoDB" id="5359669at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="230" mass="25500" checksum="385CDA14C8D4CC50" modified="2018-07-18" version="1">MLPQGSTFLQQPAHAMGKKRSHEEASHNLEPDASNGTFQNGWMNGEGILLARPCVVSSREADGLSATGLDDVITEQQGNGLPNGRQLRNHKSQRLLNGSDHASYSKTTSAMPRTTTNMTDSSMTDDLVIDDFTLHLGIGWKRINDSDHVQAAARGWARFIENHFPLTNVNVLLESKGLQSYLVESNEGFYLFTENLRQGQLVSRHATGVIQNLQSNPIRFENKDTLLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP80</accession>
    <name>A0A2T4BP80_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1406782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP80"/>
    <dbReference type="STRING" id="983965.A0A2T4BP80"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="393" mass="44380" checksum="D3646013923A040A" modified="2018-07-18" version="1">MAPFQCSVCSQLFGTRPRMFEHALSTGHEMNHCCLGCSRWFKTEGDRNAHTNSRVHAKEAVEPVPNSPDASVGESHQTFANASPILPLRFGRVTYTRLARNEQEAVFKKLLHRVHSVQSLAEEGYTVDLEKGPTVKPKKPRPSLADFRQTPTWQPAIGKRRAVVIDCEMAEAMDGSDELVSLCAIDFLTGEMLINNLVVPSRPIKDWRANIHAIDVPRLYEAIMNQKALSGWAAARQELWKHIDGTTILIGQSICYDFEALRLVHTRVVDSAMLATEAVFHNRAGKRKPGRRWGLQELCKTFLEIEIRAEGGIHDDVEDVLAAREVVLQALLKPARFQAWAEKARKDFWKPKAGSRKVNNKRMTTTPLSTRYAAPDWKPYQKYCRGYSCDVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPA3</accession>
    <name>A0A2T4BPA3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_9188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPA3"/>
    <dbReference type="STRING" id="983965.A0A2T4BPA3"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015778229" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="35"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="332" mass="35733" checksum="2CF58EEED9747BC7" modified="2018-07-18" version="1">MTLKHSALVALAAAIGAQAQVFTVNCAPLTQFRGDPIVSPGVLSSHVHAVVGGTAFSFSTTPEQARAATATTCDKILDNSNYWQPQLYHQRHDGKFELVTFQGSATYYIARACDYAPGRQNCNGAPLPIAPPAGLKMLVGDLNRRTFNASSFEDRAIQHVCLDTQPVPDTNGFPTRQCQRIRSETFFQSCWDGVNLDSANHKDHVAFPAIGDYNTGVCPQSHPKAILSVFYEFFYDTGSVKDFNRFVYADGDATGYSLHADYFQGWKDQHALELAITTCTGPNGVNDKGCSLNVGPNGPGVSGPQKLQTPAPTEDIGLNGPLAALPGNNPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPP9</accession>
    <name>A0A2T4BPP9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1426733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPP9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPP9"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="193" mass="20391" checksum="3116DA4A1303F734" modified="2018-07-18" version="1">MSSKRHSILPAVDRSGPKPPVNFSTSLTISDNAVLLGSHSITMQAETVIHPRCRIESSVGSVLVGRRCIVQERVHLGAPPDKTGKAAGGVSLGDYVLVEAGSVVEAGGTEIGEGSVIQVGSRIGSGARIGKNCTVSHLSIIASGEVLPDNTVVYSNGTWRTDKRGTPELRKLSIVKQIAMLRKMIPSNPDKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ50</accession>
    <name>A0A2T4BQ50_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1426605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ50"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ50"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="63" mass="7206" checksum="77224431794EE6AC" modified="2018-07-18" version="1">MAKSKNSSQHNQSRKAHRNGIKKPKTSRYPSLKGTDPKFRRNHRHALHGTMKALKEAKENKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ55</accession>
    <name>A0A2T4BQ55_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1442578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ55"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ55"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="111"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="205" mass="23499" checksum="54C4F16A85C0AB07" modified="2018-07-18" version="1">MNTRQSYAPTPHSYVPNTSLSATINLDEEVTLTSTRAERDLQDSLGELFSIIVTLDELEKAFLKDAIPEAEYTDICERSLRQYKALLADETIAAEFRDLEDFKAKWELDVPRATERLRATQEFITFLDAVKLGLLSKDQLHPLLSDVIQAVNRVTDKDFDSRGKIVQWLITLNQMKASDELSEQQARELELDIQQAYQGFRRTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRB9</accession>
    <name>A0A2T4BRB9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1395352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRB9"/>
    <dbReference type="OrthoDB" id="3596450at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="37486" checksum="34F1B4314003FAAD" modified="2018-07-18" version="1">MGSTDNVPMSSTSFSHLPCEIREMVWAPSVRDTQRAAHFFTVSARPRMTATGPGFELAAPTPQDDSASVEDWIVGNPSAYLQDAMLWTTCASSRSFVSRHYLRLWQAMDPRPQTDPFVACGFNRNGEEWRFKVLPSEDLFCIRPLSTGASWHVYSRYLLPGRNDRVRLTNVALDFGPAWLDDSVVEDGEVPHAADSPLGFIIRTLQAVAEGSMGADFKFWLIDRTIRKKEQALSLSPPPEDSDDEDAKRSEPLVFHGRDKRYVHIRDQSECTWDISEPTTAFHFLDWLQVEVGLNHRWMMAHRTGANWGKPPLPYRDLDELVMVLSEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSR3</accession>
    <name>A0A2T4BSR3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1433895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSR3"/>
    <dbReference type="STRING" id="983965.A0A2T4BSR3"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="97"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="185" mass="20669" checksum="455C9498CB1BB129" modified="2018-07-18" version="1">MRPLTEEETQAVFKKLAEYTGASLKNIIAPQEDGDRNVFRLSQNRVYLVRLSMANLATSIARDNLLSLGTCLGKFTKSGKFRIHITALPILAEHARHKLWIRPNGVMPFLYGGHIVKAHVGRYSEDCPEHQGLVVYTMDDVPLGFGVSARSTAESRRLDPTGVVCFRQADCGEYLRDEDTLFQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSY7</accession>
    <name>A0A2T4BSY7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1341739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSY7"/>
    <dbReference type="STRING" id="983965.A0A2T4BSY7"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="440" mass="48011" checksum="16725FF416A68CD9" modified="2018-07-18" version="1">MPFASNRRTLSTTHPLKLAQSRSVAELPERIIPRYLQVSKPGSSLLSLNWPRPPRNLLLVQKLYSPEVTESVVQFARHLRSDYPDVNIVIEARVAVPIQQELDFPIFVVDNGTNIADKIDAIATFGGDGTVLRAASLFKLHGSVPPILSFSMGTLGFLGEWNFAEHKKAWREMYMSGSDVSAARNAAVPRGRDDNMDGSRTAGEGWERVKGKSLGINRASRVLLRHRIKADILDRAGNNINHQVSNTLASQPKSGIASPKEISPPLRAINEISVHRGSHPHLAIIDIYQNGHFLTETTADGILISTPTGSTAYSLSAGGPIVHPLVKSLLITPISPCSLSFRSLVLPLDTKVTLRMSPKNRGRELDLSIDGKRCAGVLPGSEIHVEGEFVGRAGPGEEWHGGVPCVIRTEDDDPWVGGLNGLLKFNHPFGREPPNEEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT00</accession>
    <name>A0A2T4BT00_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1341640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT00"/>
    <dbReference type="OrthoDB" id="5229184at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015767068" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18837" checksum="C29F1D23B2758A99" modified="2018-07-18" version="1">MLLIRLLVASLLTAVTTASPLTDQEAIADDKAQSPRACVYGAPKKYDQWIIQYHEVKPPTQFSNRFVLDPVWVARHQNVGDADHFSLGSTWVPWAENRCQYTCNARNQCVSWVGYQTQHSKSEEGGFSCFFFDALIQPENLVPRAPDDLFKITHAYNRLCANETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT40</accession>
    <name>A0A2T4BT40_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1394788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT40"/>
    <dbReference type="STRING" id="983965.A0A2T4BT40"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="413" mass="45979" checksum="A59AC980D9B5817E" modified="2018-07-18" version="1">MSLLRSQLSPRHAQQLKDDTKSLICRLYSSHRTIKEHDVLFLRQHGAKHAKWHLSAPLKPDSRVKLSYGASLYGRDLIGRRVLDIVRDSAGNSVVLHEPSLASYIINSERLATPIYPNDATTIVSLLDLNPSRPGEDDEEDQAPPFEIFEAGTGMGSLTLHIARALHAANPPLPAPLRQTLISSPFKPHYDFATSRGCLDVSPEEQASLDEYASSRRAILHTLDRNSKHARAAYKLVRNFRRAQYLPSVDFHVGSVDEYLSQRLEQNGGRPFLSRAILDLPSAHENAERVIEALHPNGLLILFKPSISQIADFQAWSTETKQPVRMEKVIELYSTTTSEGGVHDSSGGRNWDVKTVVPRAEQGQAGNNKPVQVMRPKVGERVAGGGFVAVLRRWPVSETVQEATEEEETETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTB2</accession>
    <name>A0A2T4BTB2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1091905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTB2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="69" mass="7716" checksum="461EDBB3F72909FF" modified="2018-07-18" version="1">MTSPSPYTVSGISSPHHTTINNHLPTQSQTEGTSTINDLKETKKEKQKNKKKKTKKKHTTAGVRQWSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTD0</accession>
    <name>A0A2T4BTD0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1363619</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTD0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTD0"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="63"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="167"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB72570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="470" mass="51406" checksum="117A6320F2C6E14B" modified="2018-07-18" version="1">MSSARDINPGAPSSRTVVSSWGQNLSTSPVATLQSPTASLGGLLPRRSVPKLLKPFNTQDIKILLLENVNQTGRDILTAQGYQVEALKSSLPEDQLIEKIRDIHVIGIRSKTKLSERVLSEAKNLLVIGCFCIGTNQVDLTYAARRGIAVFNSPFANSRSVAELVIAEIITLARQLGDRSIEMHRGTWNKVSAKCWEIRGKTLGIVGYGHIGSQLSVLAEAMGMNVIYYDVVTLMALGTARQVPSLDNLLEEADFVTLHVPDLPETRNMISSAQLDRMKEGSYLINASRGTVVDIPALVKAMRSGHIAGAALDVYPNEPAGNGDYFTNNLNPWAEELRSLSNLILTPHIGGSTEEAQRAIGVEVAEALVRYINQGITLGSVNLPEAQLRSLTLDEPEHARVIYIHRNVPGVLRKVNEILGDHNVDKQISDSKGDLAYLMADISNVRYEQIKDIYESLEGLSSCIMTRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTM4</accession>
    <name>A0A2T4BTM4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1441572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTM4"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50324" checksum="CE14FB65165FB124" modified="2018-07-18" version="1">MCDEKLPQCSQCQRMRRPCPGPQTGSIFVHAVATERGPKAEKARARDSTAYQEILIAAAPRARQLHCAGKASALSPNAYQPSVAPVFDQLFLSSFITSFAKPTVGCEPHQSWMNHLHELLVTGDAPLKHSIRAVATAFHGRMAGNPAAQHAAEHCYIAALRSQRARIAPFLSLPSSRYGPNDEEIFTSMMLLYFELINPSSTASWLKHMHGVMSLLVLRGPKSCQTGAMHLLFRSLRFLEAYVSFRNRKASVFASEDWRTIPFTASGKSDIDRLIDILLLAPHLFSNKASDGSTSFSGSTVSVEHLSAELSVYSERYIQGILSAQESRQRMSGTPDESDEDDCNECSTWIDGGGDFCTSMPESLFYSAKIIIDYVAFGENAKAKEELLGAEQLLYSSLLFRIAELAKEGGELQVNVGTCVQLAFSLEVVESFGLSSACREQAQLHLKQLGWERVSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTV0</accession>
    <name>A0A2T4BTV0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1425372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTV0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTV0"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015784352" evidence="1">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="42990" checksum="AFC99E303DE7B0B3" modified="2018-07-18" version="1">MTSRVASLLFAAGLLSLSLWLLGQPLLGASSPDRGRISNLDLVLGESLPPEPLNLSSRFYASDQARAFCAAHGYRVFSPVAASGERKIYDLFMVNTELDWMEIRLETLYAHVDYFVIVESPKTFQGSDKPLTVRDSWDRFARFHDKMIYHQLTFPPSFNPKRPWDYEDLQRDAMYDQVFPQLEGRAAPVHGDVILVADVDEIPRPETLFLLRTCSFPRRLTLASRFYYYSFQFLHSGPEWPHPQATTYRGWRTVRPTNLRNGDGGVPFLRDLDKARLGNAAWHCSSCFATMEQFLNKMASFSHVWMNQEEYRDRDNIASAVREGRDVWGRDIDTFERIERNQDVPAVLRREGERYRYLLDRSGKSAGFTDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUF1</accession>
    <name>A0A2T4BUF1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1340182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUF1"/>
    <dbReference type="STRING" id="983965.A0A2T4BUF1"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="519" mass="57414" checksum="FFA9ED6EA8E86416" modified="2018-07-18" version="1">MASVDDVNFELPKLRTSFSLENDTRFLGSDDNIAGKQQISDTKHTHIEFFDVKFCPYQPLDHEPVFAAISKKHVIICRLTKDPDDANPCHVINVIRDDDDEAASCCCTWTMDASSGRPYICIGGVDAKVKIYDAISGHLIECTEGFLSSFSVLSAMEGFDVNDLATSPVNPHIIASASDDTSVRIWSVEEKHRRQPCLCILAGEGHSWNLLSVAFHETGRYLLSGGHDQIINLWTIPDLPAEPIETPLQIHYPHFSTSAVHSGIVDCVSFFGDLILSRACHDNVIVLWKIEGFSSDGPPPAQSAAPTPQNVLPTNYEDPGRLTRSAFVPVTSPQCPVQYTRLLAFHTPNCGPQFFMRFRLHHVPNQNPVLAFCNAAGNIFFWDLKRLTAHRDIMLALSNPTDKDKDKPIQLPSWQKTVIPRSRADSTNKSRAAAGQGQDLSAPGVVKQADSREFSPETLESWATKYSMADTHEPLRHHKMEASSANFVGRQASWSPGGDWCVVVGSSNTALLLQRWAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUK0</accession>
    <name>A0A2T4BUK0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1068968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUK0"/>
    <dbReference type="STRING" id="983965.A0A2T4BUK0"/>
    <dbReference type="OrthoDB" id="5321960at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000077">
        <property type="entry name" value="Probable chitin synthase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="707" mass="80366" checksum="CE42CC45FED00294" modified="2018-07-18" version="1">MAVDPAGPEWPVKDIVYTAIVGVVMIMALLEWFLWLAAFVYCLYKAFRKAEHWSINVLCVVVGIAFVAFRAIFLPIMVVTLPLPSQVSKYWPEDVVSVLQWFAFWSFSILLTVPWLFCVYQLVTNQLGRTKRMKQVLDDVTAPKVVIVMPCYKEEPDVLITAINSVVDCDYPAACIHVFLSFDGDQEDELYLNTIEKLGVPLTMESYPTSIDVTYKEARITISRFPHGGKRHCQKSTFKLIDRVYEQYLKMNDNLFILFIDSDCILDKVCLQNFVYDMELSPGNSRNMLAMTGVITSTTRKHSIITLLQDIEYIHGQLFERTVESGCGSVTCLPGALTMLRFSAFRRMAKYYFADKAEQCEDLFDFAKCHLGEDRWLTHLFMIGAKQRYQIQMCTSAFCKTEAVQTYRSLIKQRRRWFLGFITNEVCMLTDWRLWKRYPLLVIVRFMQNTIRTTALLFFIMVLALVSTVAKVKDLPVGFIGVSLGLNWLLMIYFGAKLRRFKIWLYPLMFVLNPFFNWYYMVYGIFTAGQRTWGGPRADAAAADTNTTAREAVEKAERQGDDLNVIPESFIPAQEARRAASAKGMSQGTMLGRNRSVVRPPDGIDGMFSARRKTAAGLYTHYDDSDGGIDTPPISSTTPSSSRDALQSSSFEGVVLSGPEAVVSVDQFMGEEDRRKYVIAQRAQFQRGSGMSKESPDVELIDLSSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUW2</accession>
    <name>A0A2T4BUW2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_67938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUW2"/>
    <dbReference type="STRING" id="983965.A0A2T4BUW2"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="732"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1001" mass="108960" checksum="D41EE1F63BA124D8" modified="2018-07-18" version="1">MTATSSSNRLKLTPSNSPFLTTRRPTTPLRGRPVFDSRLSLKRVVGTTCRSPTAFDAVGASFAYTAGGAVVVVRVDADNRYTQQFYRARPNVASLYAVAASPNAPSTPTTTTTTTPKANDSRNRVAAGHRDSHGAPDWADGMPRTWTSRERIKAATCLSLSPDGKYLAVGETGYAPRVLIFSLQDTSSDIPLVSISEHAFGVNAVAWSADSKYLASLGAANDGFLYVWKVDPRNGQTRLFQQNRCTSYVKDMVWLGNSLITFGVRHIKMWKIDENAGISPTKPKFPPDHPPPSPTSQKTLPGRNIILGGLLEATFSCAAVDGGRFVMCTEAGDVCILDGDDRQMKVVSILNLEFPISTVQMRDNVAYVGGKDGNFTKLDVAGLMDGRKDCVIGTSKTLTGLVALGFMTNNSVTIDARGSIDVWDADYVPGQTTEPSMHINIPGHGDPVAGICPMDRMNEMQAAFLTWSYSGKVTFWDLDGQIRVSIVVPLEGLNVTDPNVEPANQLTCVKVSKSGRLLATADRLGVLRVTDIATGDCLLDTKAHSADCTSISLYEDEGRFLMACCGRDRTAQLFHRTSTGGNIEHFQTIEFASRVVQVLVPSNDRVITCSWDRTMHIHDLVTKEGEPDAIAAILSKVVSLKASPTSMTASLDGRTIFVSMLDRSVCQYDILTGRPINCFKCMDESGIESAVLESLSIEQGAPRDSDFLLAASNTDKSIRLYDSISGAFLDREWGHTEAINGVTFVDDGDEGRKVVSVAADGTIMIWCLDVHERQKSREPSPAREATSGRPPLRKVLSKAELAEFQRPRENSTGQRTSPPPPAQPRTLRKRTSRLNLSSNTPGSKTPSQISPGNSRTTDDTPSRRTNANSPPLSPRSRLHRRPSLPALGQAARKKNSTPNLRGNTSLTAATEQACRTLRAYRKKLTSAEPINPDALGELDQELRFTAAALGDRAIRSRAMNETVLSGLLDQYSERLVTLLDEKLRLTGQPPERDTEQTQTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVQ8</accession>
    <name>A0A2T4BVQ8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1339659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVQ8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVQ8"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34189" checksum="2405A93D33629639" modified="2018-07-18" version="1" fragment="single">KCDQKSPSCSQCLLTGRTCGGYHRQATFVQGDIGTTKPRRRKAHAPDDPHSPAPRTLSSELDFLISLIIESFTPAEERSLVSAVDGSAACLDSRVCGTWVTLLPTIVARASVHLDVLQCAVRTLGYTILNKIPRALEEYGETIRLFTCTLGVAGDGSFEEFLAVVLCLTIAEGPRLFKMALRISCSQAFVTIPFSSEPKSLMRSLLDQISGLPSLLQRLDALSNGSPKDQAEDIVALYRDFDAQILRLEDWERKLNTSAASRLLWWPIALSLETGTAFPISYEFTNVLVGNTIIHYWGFLLVIHLSRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVV8</accession>
    <name>A0A2T4BVV8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1382522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="10"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVV8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVV8"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000227">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032005">
        <property type="entry name" value="TyrRSs_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16714">
        <property type="entry name" value="TyrRSs_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosyl-tRNA synthetase C-terminal" evidence="12">
        <location>
            <begin position="435"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="624" mass="71070" checksum="8532E1D87B7BA521" modified="2018-07-18" version="1">MAPQTAISKALLVLRCASSRHAVRQSPWALSQLHRARGIATSYLEKVAAGEKRWEERAIKIKNGELPHVWDLLDERGYIKDVAGTPDKIKELMRVKRIGAYVGVDPTADSMHVGHLLPMMPLFWLWFHGHPAVTLLGGATARIGDPSGRLQSREILSNADISKNVTKLHYQLSRLWHNVAALREKYGYEKDWAAKQRLLNNSMWLQGLTMYDFTKRLARYTRIGPMLSRDTVKRKMTEGDGMSLGEFMYPLFQGWDFWHMYQKLGIQMQIGGSDQYGNIVAGIDALKTVRESEEMPEMKIEDTWQNEPVGFTVPLLTDSAGVKFGKSTGNAVWLDEFKTSAFDLYGYFMRRSDDEVEKLLKLFTFMPMSKIHEVMVEHQADPSKRIAQHTLAFEVVSLVHGSQRAVQEAQQHQFRFGGQLPYYVREPAPETGILTPNTAPRKDIELPQSVLKLSPAKILLAAGLVGSASEGQRLVAQQGAYVAARPGQKRGLVPGNLDWTPMKMWFPEETTKFVIDDKLLILRKGKHNIRIIELVSDEEWAASKRIYPGQPYTGVVRQVKERLRAEAEEKGEYLSNRKIVTELNRRKREEEPIKVPNNPDIELPKRVPSYLKRGRVKKDDSSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVY1</accession>
    <name>A0A2T4BVY1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1061808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVY1"/>
    <dbReference type="STRING" id="983965.A0A2T4BVY1"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="4"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="380"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="434" mass="49223" checksum="558A1F5BA6B29321" modified="2018-07-18" version="1">MFKDPQLIQKLASNPKTSSFLADPAFMAKLQQIQQNPLNSQDLFSDPRMIQVLGVLMGVDMEMRDSPPEGAQTYNVSEDTPMPDAPKKQPEPKKEPTPEPEPLDEEALEKKKKKEEADKEKALGTENYKKRNFDAAIEHYSKAWEIYQDITYLNNLGAAYFEKGDYDKCIETCQKAIDEGRQIYADFKLIAKSYARIGTAYEKKGDLALAVENYNKSLTEHRTPEVLNKLRAAERAKVEAAKKAYIDPVKAEEAREEGNKKFKEMDFPGAVAAYTEMSNRAAAFVKLFEFPSALDDCNMAIKKDPTFIRAYIRKAQAYFGMRKYSDCVDTCDEAMKVDAEHHKGANAREIEQQQQKAFAAMYSARENETEEQTRQRLMQDPEIMGIMQDPVMQAILQQAQSDPMALQEHMKNPSVRSKIQKLIAAGVIRVGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW31</accession>
    <name>A0A2T4BW31_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1382657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW31"/>
    <dbReference type="STRING" id="983965.A0A2T4BW31"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="161" mass="18468" checksum="26B8207B1D74210A" modified="2018-07-18" version="1">MATELTVQSERAFQKQPHIFLNSKTKTKSTRPGKGGRRWYKDVGLGFRTPKTAIEGSYIDKKCPFTGLVSIRGRILTGTVVSTKMHRTVIIRREYLHYIPKYSRYEKRHKNLAAHVSPAFRVEEGDQVTVGQCRPLSKTIRFNVLRVLPRTGKAVKSFTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW75</accession>
    <name>A0A2T4BW75_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1064998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW75"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18239" checksum="02BC3D5662056510" modified="2018-07-18" version="1">MSSVTAGEGEERCRKVTGAQGRDSRTDDSFAWPLHLSQTELARLATPFTWSPDDATSQEETSSNRIARSQCRRLTTCAVQRTSTFWSIPQRVTEKLATSIFSHSDVPLPESSSPFSGLLLVVSIGILQVVDHRHRAMVFRISEETMGMASNATTRLVVPSLGRQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW96</accession>
    <name>A0A2T4BW96_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1339897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW96"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="14"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="557" mass="60614" checksum="27DC8AE0DC5E4DE4" modified="2018-07-18" version="1">MTKSSSKAKLPVQQLAILAVARFAEPLAYTSVWPYLPEMIRGFGVKRDEVAKWAGITSSVFSVCQSITAVPWGKASDTFGRKPVLILGLLSTMICFIVWGMSTSLTMAITVRAIMGGGNGNVGIIRTMVAEMVTEKELQPRAFSIMPLVWSLGSVVGPAFGGFFAQPAKQFPNVFGNIELFNKFPYLLPNLLATVFFLISAASATFFLRETLADKKEHKDWGLLVGERLTRLFRRKPQLISQRRRSFVDGEATAPLVPSIVAPQRKAATPKKEPTGMREVFSYQTTINLISYTFLAFHSVAYDQNITVFLDYPVIPRTPENTKFPFYFTGGFGLSSGNIGTLFTIYGVTCGLIQFLIYPPMVNRYGVLNCFKVVSVLTPFVYFITPYTSLLPTPATRFAAILTVMMLKAFAIIVAFPSTTILLTNSAASLRILGTLNGFATMFSGLGRAAGPASTGWAFSWGVEHGYIVSAYFFLGLVAAVGAVPVFMIVEGRGPAAASAESSDNEGDEEEGAVMLEDESPVDEDYEEASDDEEATAASPLLGASRRTTYRTSSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWB9</accession>
    <name>A0A2T4BWB9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase C/P1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1339367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWB9"/>
    <dbReference type="STRING" id="983965.A0A2T4BWB9"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015647814" evidence="8">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="256" mass="28431" checksum="60665FAB4B65DC99" modified="2018-07-18" version="1">MKLSNAVAFSLVSLPGAMAWGGLGHITTAYIASNFVSNSTEAYLKQLLRSNESDYMAKVASWADSIRYTKWGRFTSTFHFIDAHDNPPESCNVDFERDSTTASIAEKLIGRGKPYLVAQKWSAALTEKIVGGAYADEKEAWLADLDFGNFEATALAWSRECNSLVCGYVFPEGPKAIVGQELSGEYYEKAAPILEKQVARAGYRMAAWLDRIVDEYKKREANYTGVLPTDDYAEEPSDELDLELLDETEKPFVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWC3</accession>
    <name>A0A2T4BWC3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell polarity protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1424871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BWC3"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061245">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1424"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1472"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="852"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1252"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1501"/>
            <end position="1520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1520" mass="163756" checksum="6126D8BD8651D457" modified="2018-07-18" version="1">MAFLFKSKKHQDRTVTSRDGSSGSQGSIQNAPGRAVAKDDKAALQRATPTGSLHSIDNDASTASPDHAQSHVRRAGSVDTPPTSDLPLRIAPPVSNNGSLYPWSQRRLTYTSSHPSPFPRYGAAVNAVASKEGDVYMMGGLINSSTVKGDLWMIEAGGSANCYPLATTAEGPGPRVGHASLLVGNAFIVYGGDTKIDDNDILDETLYLLNTSTRHWSRALPAGPRPSGRYGHSLNILGSKIYIFGGQVEGFFMNDLSAFDLNQLQSPTNRWEILLKAEASPKMPAARTNHSMVTFNDKMFGGTNGFQWFNDVWCYDPAVNKWAQLDCIGFIPAPREGHAAALVDDVMYVFGGRTEEGTDLGDLAAFRITQRRWYTFQNMGPSPSARSGHSMTTVGKSIVVLGGEPSTASSSTNDLGLLYVLDTTKIRYPNDAPGGPQRIPQARRPSDAANPNRQPPMRDVSSGGGPPDSGNAIVGGPSSISGPHGRRTASGGMDPSGSPGLAGGPGSPPPAGAPPRAPHGGPPGPGNKLQMPRGSATASPSGPPPQGPTPAKPGPDPSAVGRVRGASVDRAAASGSPQMGMAPSPITREIIPEGEATTPTPSGHMSGMGGPVNDRRGPTTPTQASRTGSRQSSMGGEPPRGKPRPGNPGSIDTMVEAGQRATPDAAQRATADAMHRAAPEGMQKPAPTRPASPPHAAPKPMSASLNRRSSGRNSQTVALLKELDNARNRNAWYASELELARKAGYVPNPSMGPALDGKAFESFDDEDRPLIEALLAMRTELANVQNAVDKQAIVAAKQIAEAERQRDVAIQEAVYAKAKLAAQGGGSASSTPQPDGDRDEFGARSAELSRKLASALNHQQRLQTQLESAKSELDAEKRARKLADDTAAATQKRMMDLEAYKQQTSGEVERLKAELHIAQREAREQAMASTEAVAALELLKVEKEALSRKLDEVADSSNDREETFESLRAAIVASQDASAHLETKLEEERAQREKVEGKLNKLKAEHEARTAELVAVSQRLRDAEELAEKHATEARTHREAVLSGLQKLALKDESVSHNADAERAVALQNQLAAANALVKKYQQEADIAADRLRSAEERIAGLEQYQEQSSREGVGIRRQLQSALRENQSLQAAHSDLKNQLAAQQLETNAMTVQHNALRDILIERGISPTAAVRSRGFQSPRTNSPEQQSRLRNSPEQQSRLRELEAQLASISAAHEEAKQTFAIQAQDSETAYREKLSQLESDYQSAVHYVKGTEKMLKQLQEQLARYKTENGRLKSDIVELEDRLNAGPGEPGSTGWDKERADLQKQISGLEAEFRDSAAELEKNLENLKAELAESRRQRDEATQSLATQRKELEQLQSENALLEQRASDAEQKVSLLLDQVEHSLDTYRRRSRNVVSINAEGLAAANGLGLSGLSSLLGHHRHESSDGESMYGDNAGNRNSAALDNLASELETLRNHWETTNKNYRLSTNFDFDSAHPPPKREDDTPTGLGMSGNIAEWRKRLDTDNHPDADQAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWP4</accession>
    <name>A0A2T4BWP4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWP4"/>
    <dbReference type="OrthoDB" id="5141931at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="9403" checksum="F63D9698E0DA925E" modified="2018-07-18" version="1" fragment="single">DWVDKYPLLGDDGDDDGQEEEEDDEEEEDSRVKSPDLVPKPLGLIKGLDLEKDVGYVGGVGTAHRGPLWIERRQRHGVEGLPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX15</accession>
    <name>A0A2T4BX15_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1440753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX15"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="463" mass="49570" checksum="A6B1773B89C70D67" modified="2018-07-18" version="1">MSTTTTTVHVASRPAVESIELGHLDSGVSSGWQLGPEPKAESPHISAGDNERDEPPPDALTEAERWNRPVKNVGRLAFAFVSFAIAGMNDAAVGALIPYLEEYYNLSYTVISLIFLTPFVGYSVAAFTNARIHVRLGQRGVAIMAPICHLITFAVLASHPPYPALVVCNAISGFGNGLTDACFCAWVGAMDKANTIQGFLHSCYSLGALFSPLIATSMVVKGGLPWYTFYYLMIGMSGLEFAGLVMFFWDKTGAVYREEHARENADAGTAGAGTREAMKSKVTWLCALFFFAYMGVEVGLGGWVVTFMLRVRHASAYASGVSGSGFWAGMALGRAVLGFVTERFGERLCLAIYLGICLGLQLLFWLVPQFVVSAVAVAFLGFFLGPMFPGAVMVTAKLLPKRIHVSAIGFAMAMGGTGGTVFPFVIGAIASHKGVSVLQPIILALIAVISAVWLSFPRIQKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX59</accession>
    <name>A0A2T4BX59_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1440764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX59"/>
    <dbReference type="STRING" id="983965.A0A2T4BX59"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="3">
        <location>
            <begin position="185"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="420" mass="46592" checksum="E06DC0423881C26B" modified="2018-07-18" version="1">MSFTMLPFLYQTQTLRLAAKGPSFALNNAIPFQWEAEDRELASSDADRVSTITPAEAQIFKGIFHEIAQGKMPASKRRSPARHLDDGFQGLSEAPASSSQKDSSPGSARSLAEKDRISDFRDKFLSRYPRSLQNAAQVALGLHEVRPRDAEAEQDAARMMELEVDDKAARAEREALELERSKECERVEALMRACKTDAELWSVMEREVFSLPEKLHIAQAGRSGISSGASKGRRKTKAKAEENDQSALSLSEVEDEGQTASEVASQAEERVMNIHGPLYSRFLTTALDLFDTAFARPSPYIFQILPRIKELGLPSFVLGVSTPFYAKLADIYWRRFGDASSALDMLHEMNSAGLFANADVNSLISQLRNELHACTWGGQGPFVMAMMESPPYDGALMRKLEEVVGMIGQSSQDRLKDHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX61</accession>
    <name>A0A2T4BX61_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1404133</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX61"/>
    <dbReference type="STRING" id="983965.A0A2T4BX61"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB73930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="503" mass="54400" checksum="8A4AF2543F8DBF31" modified="2018-07-18" version="1">MRSPLILALAPELQLLSRRSIRASASLRAAAPPKWLSTNPGLNAPRSTNAPLGAVFFLQNRLLARSSCLDSVISRRNSRQTSTSTSTSTTPPPNAASQESQPSQSINDLAPHRRRQARKQALAQSTSSEAPLPPDASSLLTSAAASQPKDSLRRTISTFLSLSKPRLTVLVVLSAMAPYALYPVPEMLMPTMTETPSLSPLTLFFLTTGTALCSASANTLNMLYEPSTDAKMSRTRNRPLVRGLVSNRAAALFAMLCGVGGAAALYFGVNPTVSFLGLSNIVLYAGIYTPLKAVTAFNTWVGAVVGGIPPLMGWAAAAGEAATKDGSWRELLLASDGSSIGGWLLAGLLFAWQFPHFMALSWPIREEYKAAGLRMLAWTNPARNARVALRYSLAFFPLCIGLCAAGVTDWSFAVTSLPINLWLAREAVRFWKYEGHKGSARGLFWASVWHLPGVMILALLHKKGMWSRAWRSVFGEDEDGEWEEEEELDEMASMSAPTVGQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXN5</accession>
    <name>A0A2T4BXN5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1058965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXN5"/>
    <dbReference type="STRING" id="983965.A0A2T4BXN5"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000009">
        <property type="entry name" value="CTS2p putative chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000677">
        <property type="entry name" value="Chitinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00551">
        <property type="entry name" value="2SGLOBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="357" mass="38568" checksum="2016F074CDDC5397" modified="2018-07-18" version="1">MSGVSRKSRMATSVARVMYTNAVYFPSSRIYQGDSPGMLNYSCINHVYYAYASVTADGNVFLGDEWADARAPVDGVQGGLGSLMHLKQRHPHLQVVLSIGGSTASEVFPIVASSTLLRDNFARSALGLVEASGLDGIDIAWEFPSEAKHGQDFLALLAAVRIHLPDDRFILTAVLPAAKEVLQLIDLATAAEYLDYINLVAYDFFGTWTSKSGHHAQLYTMNKDEPSASSGVAHLMAQGFPAKSILLGIPTYGRSFLKSNGPGQEFNGVGGQDGTFEYSELPRKGCKEIVDRRYIAAQCVGGDGGFVTYDNPETVKVKAEFCKQKGLGGLFYWNGPADSRDQSRSLIAAGFRALHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYE1</accession>
    <name>A0A2T4BYE1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_6476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYE1"/>
    <dbReference type="STRING" id="983965.A0A2T4BYE1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="648" mass="68617" checksum="B3C447CDDB1BA3A2" modified="2018-07-18" version="1">MASRSGSGSGFAVGLERTQQYPAWSLPSPPQAASRPPASRPPAPSSSSPLPLALPPFRRSSRPPDLAAASLFSAPVRASAQNPAPGLLGAPQQQREQRQQQQQQQQRLYAQSSTFPSPRLSSASAASAISAASASASASVSSAAAVAASSPLLNPPSATARPILPPLPQISPLSRYSTPRQQRHSLFSPSTPASASAPASASPSQPGPANNNNHNHNHNNDITGTGFSTSTNISVRLGSSAFANPSGLSTLQPDPFSPLNSPFDRPPVFGPQSTNPWSAYASQLSQSDGWPQDDAAPEIFSRSARSRALSALDRLLNEATFGSFTPQQPSLQSPSQLPQSPFSRFPPPSPASASSSTTAFLTAPSPLTTTNTAPSAQLQPQNSTTRPSRMSFVANTALPPTVPPVSEQAFSPLNTFGGFGFQNDNGELDGLFCDLDGFQSFPLPLTNFSGASESSTFNTMPTTSGRLRSRVPPENPPSSTAVAPSRKRRRISPSAAAPPPPSAQTTLIEDEFDDIDSLFGSSPSRPASANSKVEDYTTIDLTEATDVPEELKKPEVDKRVKLSAFQCVICMDDVTGLTLTHCGHLFCAQCLHSSLSMEPTRGKCPMCRTKIDMKPRATYSTKTKGYWPLELKLMTRTRQGKRKAQELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYG4</accession>
    <name>A0A2T4BYG4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1424094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BYG4"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C50" evidence="7">
        <location>
            <begin position="1854"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1280"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1294"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2067" mass="225544" checksum="AA5568572F895AC7" modified="2018-07-18" version="1">MASLQAKVDAVKAAVASTSSCTPATVVTLKDLLLLESESQPSRPKATASRSTKAGATTKTKGSAGRDTSPGSHGETLSVRERAALATHIINVTLKTLSEAAKPQPLPTPSKQAGDPREAAGMQSIRRSSSAPLSPVQPRALNRLAASSSVEANIAKSQSPAQSTGCLATVECARTAFSALRTIKGPAKPDETDFQLETGMSALAGKLLSLGMHDQSLKELRVLKRRLDSIITGKQSSSAKSGSESTTTTSAIADLLNFQAAVPKQSLVTVTGYQMQVLKLVAATKKPSHIEAILPYLADSYASSPFNLLSILAKDGAKEAAKAARQMASISQLLLSLAPSISSQEDAVATEPRLSPSPRAAFELQSLAFRIQLEWWKLAGHQGKVDDDVLSPFSRCLRAYTRRQRSEDGSIYQRVSEAYDAIMQLIHVQKYRPATSFNSPLASIHQNLGSIAQAERRYTEAHRWFLEVKGSLTAGQESSVLRCSVSARLLAVALKKSQLDQTVEPLLCEVIEGLDGSLSGTIAELNELLESLSLARRSVVGLLMTCLGPKAAESTVPEALISYLKTFVLKYPRFVRRWTGLPPGKDAPPKQVLQFDQRRQLVAQSIGQTLDATLMVIKCDIQSESMEWHAIDDVLQHCVSLLECMAASTLSTNKVDNLGPYSVKVSSLYFLYFSQLKKKSSRSKDENKHLLQALHRSVDVVKNCTEAEKEKAQLSTKLEVFADICKSFGRSEEAVQALRAICSNMAEKGALSDVAEALSVQPPSTAWAINEKVSLMSRTLRSLSKFDSSWNEWTFPLPEAERAAVLEHLMYLNISGSSTPLGLHDAGVAALLRLYTLDKYPLRRLRVLLHLCYQNLGEEDQLAQILPLAEETLECVETGDKAGDAALARFVPHLKAYCFSISALIRVDDTMSALLNQAIDSWKSMVGTCQTQDELLSLIDDPQGLLDHLRSLHQLAGLRGEARLQVAISELTIALSRVFVGSTEANGDGLVLSHSHLAAQYVQIGLYPQALQTLEEAQELISRYDGLSRQVQAEFYLSQAEYHTGIGEMETALECLSKASEICNAHYSSWAQSKSQASMIMSITALLQSVATLQAGQIQEALSYVKTSVRLLTHDWTKLEAAMGARPKNVADMSLSDMNTSITDLTASRGKASGPRFWALASPLIRSLLHISSVYAHIGMFQETIYYAESAWKIAESTQSSLYKSQVAIWTGSVYLRAGKLPKALATFKDAEDQLPRDVCSARVRFARQLGEFYWEIGEDDKAAGYLQIAEETARLLSTAESVSGGDADMEPPVASTRATRSTRATRAKAAAVSKASKRDTAETKPSPPSTDATQLPKDIYYASLHAAIVMSRTLGLIHQKDWNSALQALEQLRDLPKLVGVLSQEQVMTAVTLIGHSMEQMTSDPVFSVMQDSTISFPAVSAMALASPTKQPLVKTDKETDFPAFADALRQAQELLVEAHASALSSADSSMVRRISTLLQSTLIFLSATLASSRCLSGSGLGTVAVDLARNVTWRREQQTLGGLNSDAASIRTGSPVHNQPTAEAMADMASFQENYVDLIPEKWSVISVSLSDNRHDLCITKFQAGQGPFILRLPLERANSRDADSEVFNFEHGREELLELIKLANESSHSARDFTAKGERGAWWAERQALDSRLKKLLVTIETTWLGGFKGIFSQHRKQADLLARFQRDFHQMLERTLPSRNKSRGKKTTTKTGTITLDPRILDLFIGLGNPTDPDTDFDEAMNDLLYFVVDVLQFHGERNAYDEIDFDSMVLETYDALRAYHNAASSSGREEGTHTVLVLDKLLHAFPWESLPCMDGLSVSRVPSLACLRQLLEEAGRGPTSASQGHFVSAKAGTYILNPSSDLTNTQAFFQSAFLTLESWSGITNKAPKESEFEQALSTSEIMVYFGHGSGAQYIRGKTIRRLEKCRPATFLMGCSSAALTDAGEFELYGPVWNYMMAGCPAVVGTLWDVTDRDIDRFAGKAFEEWGLFAKGTFDVSSSSSSKGKGRTKSFAEEVEQVRLDASVSDHASLAEAVARARNACRFKYLNGAAVVLYGIPVYIRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYY0</accession>
    <name>A0A2T4BYY0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1379857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYY0"/>
    <dbReference type="STRING" id="983965.A0A2T4BYY0"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF130">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="333"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="607" mass="67874" checksum="12A841AA85A64FEB" modified="2018-07-18" version="1">MGQAPSQTRRTRRTHEELTQELAYRFKEKCFTSLEYYSLKDVFKKLADQQGDIRYLKEDTIARFLEIPDILGASPVIFQMISYLGAFPFLQEAPVVLELAQLIMVVVIMTERYKRVLAKGSTDRTKLFFKSLAVYDRKVMETGSTPRNSLSKDAAVKSSATSRGFAIDQPMDEEDEGDDEEDDLVITAFELLDINEAAKHGEAAAMKEAIIPTDNFRKLIMLLLLIAPLDPQESLSQYSSRVAGHELESLRATAECVLASFVDVETSPGIGYTRFKTVIPVLFPNLFAGFNGLFEHFLFSKDLDFSKHKVEKPGDAQLIVGKIAQPLLPTPGDIMTEHTLSQLSLFLPGDSLFRRVRLLYSGNDAGFSMGSLQTKIFNWRAPTILLVSGSRLADVPEGGQEASFASSLPTKRFPHGSKSERVTFGVYVREPWKHTHKECFGDSETVLFQLEPIHDVFPASTINTDYVTFTKPPGNRPCLAFGCPHPKPTQSHRKEGIHALGAVSLLFDESFEFGVFNHDYKSKGGAFRTSIVRKYDFQDRFRIENMEVWGCGGDEEAKAQAERWAWEEREAEARRRINLGTGDIEADRALLEMAGLVGGNRSGGSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZB2</accession>
    <name>A0A2T4BZB2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1380120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZB2"/>
    <dbReference type="STRING" id="983965.A0A2T4BZB2"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="277" mass="30205" checksum="16F032EBFBB713ED" modified="2018-07-18" version="1">MAPMSNHNLNYSSNYGEDLTARVNVLASCYVVDSAANLKGLHYCTTGGRSGIPEVPSSGLPSPPSSPPLAALTSSNELALLPKQKKRDIPGRRLERRGGAALMIREECERFFCETMKTVFLGERDQSVHGSGLTGAYLQSPPPDNHLADPFNQGPDAAPAGSRIDAWMEVWDYAGGSSFRAFVADDGREKSLFVFFDIEGVLGRDLKKALMALIELADGPLACSQIVACLDRRLPADDAHDLIKSLQWVGFDMATLDHWAKDLDVTSKQWVFMGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C004</accession>
    <name>A0A2T4C004_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1336837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C004"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
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        <property type="entry name" value="Znf-CCCH_4"/>
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        <property type="entry name" value="Znf_CCCH"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CCCH zinc finger"/>
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    </dbReference>
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        <location>
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            <begin position="1"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1459" mass="159627" checksum="9DCD4EA5A55A1D7C" modified="2018-07-18" version="1">MQSWSGSGQNGATDGHNSWQSGFAYPNQGNQFDPSQAWPQPAAEQASYSHLNQPDPSASGFFEAPHQGNAFLAGGLHSAAPSQTPFHAGHGALSLNQQFSQASPDVMDPAFSNIHPELYGHQSKVNLGGDGIGHMGQVQGHPHAAPQAFTQHEFQFAPQNEQLYDATVPYNGQPQQVSQPARQGSHTPVQQFDNLHGSFPQGHRFGQPGQPAPVQHQQQQSYRQGQAFSPAVGGQGDQYQLNSSIAYQQPNSQYNTQQQGYAPQKPNAYTTPPQGTPAQQTQALQHPSTPSSNHQAMPTSHNAASAAQYGAAQPQINTTIAPAAAPLTAAQPATEATKKRKRMTKSVPEPVVPEQPTYPIDVPAETLARRDDESESLPVPVPTAEEAQLIAQFAKRSKAAQIKYPTIRGLPHLVFDGTIKLPAPKSYDKLSPCIALPPRNDRPAVPELGYLPCEIQGKFSAQYRPSADKGGLDERREEASQLLDEYDRSMQALGKRRPKYTEYPHAFKEQLKSDEASKNKAEKRAKKEQEDDRAKPIRAPVRPTDPTEAAAWDAIGIVHIEASVPRTNALIAGRVQQAGEFFIKLRNEMNKAKVDVDNAIKNKVPDAELAELKKEAEQKKEAFYRALDVTLEHADDGVLDNLGGHQKLVLSLVNAMIASIKAGDFSGKLPKALLELFTHFRMTKKIAETPNFETVRKRFEDKGDDDVKEMARDIAANMKKVIRSDSDTSTGYTGTSAASRAKAGIKPSAEATSAKRARDDDADSRTVKKIAVEPGNSSLSKKLAQPKAHPPTTSKIIAPKATSSLLPGKARPVPKPAVKPEADSPSGSGDDKAKVDAKKPATKTEPGKVVATKVEAKPHSSKPASTQSASALSGIASLLDSINAPKAPEALVTVTRETRESSTPEDPEEKAKRLRKEARRKLRVSWKSDEDLVQVRVFHKDDEEDEGREGNMIRDAADDRSEGMVLKQRANVDEDEDDDDIPYQPWLGPVATDFTVLPDEVRSKSFVTRGGTVTFTTDEQQRIAEREQRELMAIYTDVNDIPATPKSPLPEAATPHHDAKTAYLPREHPQFEEIQLRWRDEQQYGPEEALRSAMKRLDARNSPSSKLDTILGRLQGGASASTSSSQHVPLMQSRQAQLQLPLLLGPSVEALVLALLQSDKVKAWRDANPVSYGETVRPYNYTDPTVRLNANAVEEVARMLIGKPFPATSPPEWLSFDQERVREWWFGYNKEVAARQKKEEEARARAEAEANALKIAAATAAAASNNNLPQDWAAQYAQHQSYAPYMALLQQMTGGQHQAIPQPPSAVPAASQIPDGQLQSILAAINQPQQAAAAMQAPSLNSYLNLNPNDPSYQQLMMLTQMAQGQQPPPPPPPPPSYDHRGERGDRGDRDRGERGDRVDRDWDRNDNPRGDHGKEGRKKKGTLPPHKPANKALIGTKPCTFWQQGKCARGDKCTFRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C028</accession>
    <name>A0A2T4C028_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HP_PGM_like"/>
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    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
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        <property type="entry name" value="His_Pase_superF_clade-1"/>
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        <property type="entry name" value="His_PPase_superfam"/>
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    </dbReference>
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        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015675189" evidence="1">
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            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="EMBL" id="PTB74918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="375" mass="41742" checksum="B37B85A872BE618E" modified="2018-07-18" version="1">MKASLLSITLALASGAMAWKQVSDCDDIKYTSVPGFFLQDDPSTDPSSFDYAASNFGLINRTYPTDAKFDPHHKKTQWQRFANYVESLNSECRKEDKSTYKVLFMGRHGEGWHNAAETFYGTPAWNCYWAEQDGNGTAAWADPELTPNGLQQTTKSNAYFKSRFEKEGLPFFESYYSSPLKRCLQTAQLTFGNQRLPPSHPFKPVIKELFRESISIHTCDRRSTKSQIHAYAPNFQFEAGFTEEDLLWRGKEDEGETSAHQVARSKEAVDDVFSHDDNTWISITSHSGEIGAILTVLNHRSFSLSTGQIIPVLVKAELVEPTAEPTSTYASFTTEPTCKSPPITSIAGQGCVCATATTTTFTTATTTPGCKPHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0G6</accession>
    <name>A0A2T4C0G6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cellulase</fullName>
            <ecNumber evidence="3 10">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_66627</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0G6"/>
    <dbReference type="STRING" id="983965.A0A2T4C0G6"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015774904" description="Cellulase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="13">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB75036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="242" mass="24364" checksum="63D2B093701BC688" modified="2018-07-18" version="1">MKASLFLSPVIVGAVSAYKATTTRYYDGQEGACGCGSSSGAFPWQSGIGNGVYTAAGSQALFDTAGASWCGAGCGKCYQLTSTGQAPCSSCGTGGAAGQSIIVMVTNLCPNNGNAQWCPVVGGTNQYGYSYHFDIMAQNEVFGDNVVVDFEPIACPGQAASDWGTCLCVGQQETDPTPVLGNDTGSSPPGGSPPATSSSPPSGGGQQTLYGQCGGAGWTGPTTCQAPGTCKVQNQYYSQCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C118</accession>
    <name>A0A2T4C118_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1335455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C118"/>
    <dbReference type="STRING" id="983965.A0A2T4C118"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="336" mass="35958" checksum="4B94B2D580B51613" modified="2018-07-18" version="1">MSRYAAVHAWDNLAGQGDARPTAHQVIQDAGKTNLQGQVIIITGVSSGTGAASARALAPTGAELYLAGRSIPKAKAALSSIADQPNVHFLELDLASTASVRAFAAEFLKQSGGRLNVLLNNAGGVLAERRVTPDGFEQQLAVNHLGPFLLFALLKDALLASASPSNPSRVINVSSVGHRNGTIRWDDPNFEEGEYNPAVAYGQAKTASIYAASEIDRRYGAQNLHAWSVHPGAILDSAFLDNSGWDKSFLDGMVSAWPKKLFKSSEQGAATQVWAAVSDDVLAESVTGKYLEDCSVAVHMSKSDSPEWRGHADHTYNEEDAKRCWELSEKMLGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1G1</accession>
    <name>A0A2T4C1G1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1274189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1G1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="90" mass="10197" checksum="334023665C8AB27E" modified="2018-07-18" version="1">MIQAHIVILVFKGLLLWYLSTVYLYCCATPTLASPFEANHQIIFPHPLVSSMTSAKVFARLPLTMSAPLAEKSFFRSFHQWGRQNARSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1M4</accession>
    <name>A0A2T4C1M4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1471163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1M4"/>
    <dbReference type="STRING" id="983965.A0A2T4C1M4"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="245" mass="28343" checksum="70263ADB2B5A83AE" modified="2018-07-18" version="1">MDQVLGGDRLPLETWFWEMPTCTRWWTAATVLTSALVQCHMVTPFQLFYSFRAVFIKSQYWRLLTTFLYFGPFSLDLLFHIYFLQRYARLLEESSGRSAAYFSWLLVYAMASLIVLSPLVSMPFLGHPLSSTLVYIWSRRNPDTRLSFLGLLVFTAPYLPWVLMAFSLFMHGTVPRDEIMGVVIGHIWYFFNDVYPPLHNGSKPLDPPGWWRRLFEGRRSEDDSVTDVNDIVGAAGRDMAAVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1M6</accession>
    <name>A0A2T4C1M6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fork head transcription factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1275403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1M6"/>
    <dbReference type="STRING" id="983965.A0A2T4C1M6"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="134"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="316"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="316"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="658" mass="70608" checksum="D1126BEB5141CFC8" modified="2018-07-18" version="1">MPASAKRAQRGRRDPRKDKDKDEDVAAAADLESSSPSRPAKRRKRALSPDHPDSLGLPPGAPSQAPESSQSQSHSPRAQDDLLVAQVTQQLRSQPVQASRDHSNSIHEANGNGVKAYAKVAAQDWTYYITKLNVNIGRSPEPSHGPPAGSGSDSGQAAVHIDLGPSKMVSREHATISFNSKDEIWMLHIKGRNGAKVDGQPVKPQTSHPLTSGEVIEIGNVEMMFVLPSELSALHIHPMFLQRCGRSIDTPKAAQPRQYALGTPAKAGVKRPGTPTSSQHHSAATVVKSPVAASTPGGLLGASGVDLSLDENQHIKPQYSYAQMITQAILNAPDGKLNLNGIYNFIMSTYSYYRHQHAAGWQPQNSIRHNLSLNKSFDKVARTTDEPGKGMKWHIVPEAREEMVRNAYKIGRGGHRGSSVPSSPSHLNYITHGPKDVLARDPSSARKRRGSPLVSPPPQSALRGLQSTPDRAYGRKVDRSSGPTADGSPLPRARKSTAADASFSGYQPQSPTLTSSYMQDDNASFVTPAPPRVHPKLAPPSTAQRPSQHMPTSSPAPFWKYADIGSTPLKPLGPYEVSPSRVAREAPPRSSSPPTLGKSPPSSPSRPQKLGLRESADPADEPEEEQGFDLMKGFQSIGAYHAPVERGVPIGTALKGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1X8</accession>
    <name>A0A2T4C1X8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1256444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1X8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16591" checksum="A863DF1E76621C7B" modified="2018-07-18" version="1">MHTETCQEPFVRHDARGSLCRERFWGRKAVRILLALRRTTAFEAATARMAEIGVSDSAFRSGAIDHCLASCRDAVPPCPHASLGQPGRRTRAEAEVTECAGVAHSMDRHVTEKGEINTAAALRTKPSERSSGWRLAKPQTVLRLSLNPCLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Q2</accession>
    <name>A0A2T4C2Q2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_5301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Q2"/>
    <dbReference type="OrthoDB" id="4898519at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="109" mass="12141" checksum="9B38248C794DC741" modified="2018-07-18" version="1">MDRDTPRPYPYPQAPPPPHPPPPPPPPYAPTPGDQINQLHEELMLIHSSVATIYENMVSLDTALEYQGRHEVIISVARQTATVTMSIIQSIYPIVSSMNYKLHVLGGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C439</accession>
    <name>A0A2T4C439_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 10">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1401786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C439"/>
    <dbReference type="STRING" id="983965.A0A2T4C439"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="803"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="876" mass="98202" checksum="32A577A559E5C249" modified="2018-07-18" version="1">MQPAYRSASRATDTVSSYFSSSVPPDSPPYRRGRSQARRGSEDAIESEYGGQSRYSPSIASSRPSTAYITGSTTTSRPTTPSRRSRSGATPSILGQSESHDVVCAVSEARSVAPTVGIATVNLSLGEVTLSQICDNQSYVKTIHKLQLASPSRIVFMPSACPPNDPSTFFTLVQRLIPEAEISSHDRSAWSETAGIDFIEHLAPEGDVGPIKVAIQGKYYAVCCFSAAMKYIDHQFSISFSPQSLRIRYQPSEDTMMIDISAMQSLEVMRNLKSAKSKECLFGLLNHTLTPMGSRVLRNNMLQPPTDFDGFIMTRYDALEEMVTNEEMFHEIRKALKLFHDVEKTLTKLVTIRNTTGVFAVEEQITHILMIKSFLESVPELYRALHPAKSDLLIKIRNLCRPETTVPILLGIRKVFEADVTYMKSPLDLRNQRAFAVKSGISGMLDVARQTYRELTEVIHAHSAEVSEDYRVSASLKFDNRRMYWFRIPTVDLDMESIPPEFINVIPKKNHIECQTLDLVKLNQRLLDTSNEIIMRSDAAIRDLVKELRRQVPPLFRVCESIALVDMISSFGQVTTTRDYVRPGIEDTLALKSARHPILDKKMASEYVPNDYYASQHHRFHCVTGCNMSGKSTYIRSVALLQIMAQIGCFVPAEFATFPVIHNIFARISAQDNIEANLSSFGVEMREMAFILKNIDNKSLAIIDELGRGTSVRDGMAIAMAISEALIDTGASIWFATHFVELARTLADYPGVLNLHLASDTSVGEGGVPQLTMLYNATAGIVNDEHHYGIALARAIGMPDSFLKFAENVADDLRKRRESSRQSSEYYKEMQRNKLVQNFQEALEEAQRSSNKEALPGYFKRLQDEFELRLNEINEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4N3</accession>
    <name>A0A2T4C4N3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1333020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4N3"/>
    <dbReference type="STRING" id="983965.A0A2T4C4N3"/>
    <dbReference type="OrthoDB" id="4152802at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="298"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="761" mass="84458" checksum="A98103E5A1C9849B" modified="2018-07-18" version="1">MALWPFRTRGDKRSTAAGETASGRKIARATSVRRNRDARRYSFSPNRQDAIHVDRAAPNQNERLTGEDAHAHNTAWQDRVPTLHHKRSGNQPSRRKSSKRKRQDPNREAEIKAMSAFTPARATTETFATGRSSKHDHKRAKTLPARAPWEGANSDLSLPIPMSITSRMSSDSNYSAYRVTALDALAPRPTLRYQGARLLPSRASVPTRSGSQRNRLAALDEETLKAHKRIDELADEFDAGELRELMERDARRRERNRQREREKVERRLARKAEKQRMEEETARERGTPSPENLERGVMGREVGLGIDPPSTVVTSSKQRASPEPMSDIEEYAPTTPKTPQPEPLETFHRVDTAPREPEPTPAPETLPQTAGKQDERVPAVPPAILKLEGHLIPKTSTSGSTSRTNRISFSTLLRWGRSRRSSGGPSSFSNTSREEMSAVVAAAAAAQAHSQARSTDSPVSSYSGNYLSSKPGSGPPKRTRSRFREDLPELPLSPPRSRLQSPEADASLPSVAEHKSAVPEPIQIPTMRDDTPTSGHRSIDMAQVRASRDKMYGSHSAEPHLSMSLASVDSEASWLSGRVGSQRSQRLSVRDRIRSRQQEREAIPDSPSNSAHDDLEITEDDYMSRLSPGPTDLTFNSRLSGEGRPSSDGEEMVDEGEVRWGAVGAHPQFVSHANNRDTVRSREGLLNIDSGDEEDFDAPISPVSPITPSMDEKVDIERATSVRMDRNHARNFSAGSAKLLEIHPRESTDSKRRSRERSNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C592</accession>
    <name>A0A2T4C592_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_301628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C592"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="192" mass="21486" checksum="CED1C39A03A2B719" modified="2018-07-18" version="1">MQTRRKGRTGIWRRGNLLALLCIIYASPFRVKGKKLQLLLHFDMSRGLAGWLAGWLADSPGTFFSDLIPLPLSCHFCFSFFLTSSKLQYRDPGCWSCLISHTPGNLFAFFARSRTSRLGFWRSGKLNRGRGASAGPNSWELPLGIELIALQPCSGRAGERDSSTTGKIGTDGLIRQADFSRYTHWPSSRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5D0</accession>
    <name>A0A2T4C5D0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_301496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5D0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="176" mass="19749" checksum="8C64E70826556D4F" modified="2018-07-18" version="1">MELVTCCCWLSGILVHCAFIFIPPSFFFCFCPLFFFFFFFLLDYCFHGHVTKVRSLAQAFAAPPALVLFPTYPMFIAMPRIPGITMLSCPCMLHQAIAISNSFCSCFVLRPLNIAHSTQCLHSSFASQQRHDRHPLNVVGSLTSCPEPRRRAIVTGEKKKHKPWLKGGEIPGSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Q5</accession>
    <name>A0A2T4C5Q5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1462695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Q5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="194" mass="21202" checksum="640C0AC2F4CEB6DA" modified="2018-07-18" version="1">MTPSNTSAQAPLRTAAPCVPQRLPTEGPMDARHSPRINCAIAEQSKDPDLIGFMSPMSADPCLVGLPGRSLKLVVEERTTPLHVPAPDCQGRQGRPQSREPVFVSAESQTIAMVSVRLCVAWKAADPDSGGEANDDRQTRESDVALKQSWGAFLGRATASRRESCQVLPFLSQAEMRVFAWRVVRRRLIVNLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C601</accession>
    <name>A0A2T4C601_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1391491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C601"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015430859" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15125" checksum="D86EFD787FC14D7A" modified="2018-07-18" version="1">MACPVLIVFSVFPSSLLSSDILTAICHHGRGKTDDLERMLFVESFKRATGCDSDDGDMCTGAEFPCINDNRKLPPCPIVIDSAVSLGYSRSREAEAEAEAGRAHEDSTGKEYERTTDYGARTAAHIAAPAARTWNAAQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C615</accession>
    <name>A0A2T4C615_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1391494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C615"/>
    <dbReference type="STRING" id="983965.A0A2T4C615"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="336"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="856"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118859" checksum="C2E49D1074CF5A4C" modified="2018-07-18" version="1">MTKIQKEKNSEAKTAPGLHENLFSRFMSQVIGSTSREMEAARDTASAHEGKKTAAPKDNADLKIIAEENVCHKTSTNTRPDGLTVVKYSSVVKQEDAELEQTRDNQGGDAQTAGIAGSSESTGTGAQQVDGDVMPDCSSAVPDESDDMQQSKEIATTTGGSSSDLEGHNDTVDEKKTDDMISEKVVGMVEREEEQEMMPTISSLDVEPTDKIDKKNREEHSSEKKRKEKRSHKRSKSGDRHAGSSKRAKTSKTSVLGDEAVVTKVSGPDCHAKALDIEQARARIPTNCSIRHEYDQTDELKGGKKIAKSDKFKRIMVTELKDHQLTALSWMVGRERESPRPAAGGIIGDEMGLGKTVTSLACIAAHRLNKSDRKKRAQATLVIVPSRQTALQWQEEAKKHWTEEASENVILFSPNNDLGPRNYGKQMIVQLRNQYPRQEFMDALDRLYADEPRVHRREFRKEAKELFRVDWFRVILDESHEVTKWNGRNLKACCAIEAQHRWALSGTPILNKPMGEEKNTAKTGRFGSRRADEALAEFYSYATFIFCNFIGNRRVFKNDYIYQDATNDYFDTMSSSLMYRRTADKNLKIPPTTHQELYVEVSAEEEILCKRQDEHDDCKEKKGMPIFEDEHGVDEVEDSMPEQGKAGNKSRESSARSIQSSRQMRLRQALSHTYCLENFLMGQDYLDEGEFRSLLENLRSVADKKTIIEQLEADPEWQDHLGKYQTGLNILKDRTEESLRGVFDMNDIMSLLLVQRLVRTSECGGAKGHSQDLSRYKYMFEPTHDAENQFASRTADRLMTLEVLAAKAREDKSYVEIGRDSIGTTVQAKNDSSVFFVASSYFPEVTPPPSSRLTATVAVAMTWLTEAPQDKIIVFTQFLPTLKMLGYLFQILGVKFVYYSGVLPKQKQDHAMNAFQNDPKTMVMISTMKSGGQSHNLTVANRVIIVDLWWNKMAEKQAISRVARMGQTKETFSVRIVTKHSMDDRVIEVQTAKEETVARMLQDDGHERTEVDDHVLKRMFEPKSAKEEKPKKRKGVKQSVTDTIYKEESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7A8</accession>
    <name>A0A2T4C7A8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1353533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7A8"/>
    <dbReference type="STRING" id="983965.A0A2T4C7A8"/>
    <dbReference type="OrthoDB" id="3256520at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="246" mass="26818" checksum="9D8646C411DF3638" modified="2018-07-18" version="1">MAPTVIAFDLYGTILSTDSIVKTLAGIFGDAKAKTIATQARRYQLEYTWRINSMGMYQPFNELTRWSFRHAAAELGEKLSPEQEESVMSAYDGLDAFPEVEAALKLVGKTPSIEAYVFSNGTESMIASSLKTSPSLAGSSGSVFPASRIVSVDPLRVFKPDRRTYDHFAERVSLESRPDKIWLVSSNPFDAVGARAAGWRSVWVNRSADVGWVDGLSGAVGLEPTKIVKGVDEAVEEILKTDAQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7L9</accession>
    <name>A0A2T4C7L9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1330425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7L9"/>
    <dbReference type="OrthoDB" id="4837923at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="618" mass="68085" checksum="3DF22403FEE51818" modified="2018-07-18" version="1">MEKLKSDPSAGSKAASYPSLAQISKSASNEPSEKRSMSMQETSHPLSSQPPSKISRRRATSQLASPVVVSEVAIAEKPYKATQSRQPEEVPKSYYLINPKVPGSAWYITKAKKTSSKYDYEVERVQTHLVHIQPDRIGYLVETAIRDDVTGAVADRSISWTPTLQHESSTISSSSTAIADNATGPMPGKRANRFERDVSEVRISSQPQDETDIILEHKDIPLITKSIIRQLRIAGFRQHRPSMDRDESSWSEDDEELENTIKASLMEFRSPIQRSDTFETEADVSSPRGGKLPVQSARENANRHMKPRQSVVADPAITLSTPEPAFAVVEPRHKHKGKRETPSRTRLVSPHSVTAITWTKHSGRLGEPPETPASATPSDENSAETRPNSSGNEDKQGQEPETSQASLGLSSLGPTITSFPKLLSRHCTREWIKPIVNLEDTSTSSSHQEMNTQASDRSRHHQAHFDEDPVSMSWDGETLHSSNASGYFADEASSARRSTVSQSSTRTPKHFGSHLGSAAHRRRSAPADESRVPSSHDHFFPSILGKFFAGRNREHLPVTPPRSGCGSPPKRTSTLSLEDRARIHEALVGSSGGPVDGRRRDTCSEDNRPHVCADDMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7N6</accession>
    <name>A0A2T4C7N6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1400484</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7N6"/>
    <dbReference type="STRING" id="983965.A0A2T4C7N6"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="142"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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        <location>
            <position position="247"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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        <location>
            <position position="247"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="254"/>
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        <ligand>
            <name>substrate</name>
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        </location>
        <ligand>
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    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB77553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="432" mass="47235" checksum="6EBED9B232D6C5AF" modified="2018-07-18" version="1">MASLTSWVPLDRNGDFSIHNLPFGIFSDGGSSQPRAGTRIGDFVLDLSALAGDAQVKQQLGSFSDLEGVFSQTSLNAFAERGRAVHRAVRADLQRLLSESTDVPALLKDNKTLKQKALVPVDNVTMHLPMQIGDYTDFYAGYHHAYKVGVLFRGPDNALQPNYTHLPVGYHGRSSSIVVSGTPIRRPRGQILPNPAATPKQPTTVPCRRLDFELELGCFISKPNEMGEPIDISKAEEYIFGFVLLNDWSARDIQAWEYVPLGPFNGKNFGSTISPWVVVPDALEPFRTEPLKNDTPIQDYLKEAQKQSVFDIQLEVGLTTADGDHVDLTKTSGRNLLWSFPQMIAHHTVGGCPLRAGDLLGSGTISGTEPRERGSLLEMTEGGKADVQLEKGGVRRFIEDGDSVNMRGYCEKNGVRIGFGDCEGKILPAHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7X6</accession>
    <name>A0A2T4C7X6_TRILO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">M440DRAFT_1217632</name>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="PTB77612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="178" mass="19545" checksum="01BBD4D1285BEF11" modified="2018-07-18" version="1">MGIFLRCGVSPSPALCSPGAEGILWALSAEPWIEQRGRSCKGPFPLLSRSRGCMMGWGWRDAEVLLFFRCRASGGRSNGCIQQGSEPGTTTVQGWDAWIRRGFFFFLFATKLQTCKSPFNAYDRYKGVAQRKALGVCVCFGGAPCVRSCNPRAKIVSVKRQIQKRCPSAPLLCPFPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8A0</accession>
    <name>A0A2T4C8A0_TRILO</name>
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        <recommendedName>
            <fullName evidence="2">SURP motif domain-containing protein</fullName>
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        <name evidence="3" type="ORF">M440DRAFT_1375323</name>
    </gene>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="321"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
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            <end position="42"/>
        </location>
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            <end position="62"/>
        </location>
    </feature>
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        <location>
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            <end position="73"/>
        </location>
    </feature>
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            <end position="139"/>
        </location>
    </feature>
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            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
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            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="746" mass="81192" checksum="0E9CC54297EF8040" modified="2018-07-18" version="1">MSSSKDSADPLRLEPKFQKPVRQSVFEKQKAEAEAKRKREAAETAAVYEDFIKSFDHDEHDNANPSATAQRNQRPGFGGFGGPPPSGHGGASRRHFGTSSALKSGPGSLGTTPVPFAKKRSFNDFSKEPEGRPTLKFDDKSDDDDMVDPAEEKAIARPTLRLSNLPPGVSPATIKSLLPSNLTVEEVKIQPPAGPGGSERKCAVAIVTLSKETPATDMDSAVSSLQNKYMGYGYYLSLHRHLSSAVSSTLSGLASSTSTSQPFGAKPVDQESSAAHNDHSRHGFQRGFAPPTSYSHGHAAVNRTNLLCVPVKPPRDIRMIRLINKVIEGVLEHGPEFEALLMSRASVQREERWAWLWDARSQGGVWYRWMLWGVITGSHLKQKKGKYVPLFDGGHAWKTPETGLRFEYTTKLDEFVSDEEYDSSEDEDFDGDAPRDGGPAADDEKTFLTPLGKAKLVHLLSRLPTSIGKVRKGDIARVTAFAITHVSRGADEVVDLIISNVERPFSLAVTDLEKKREGKGDHTTPGADEGAAASENTDASAATLVGLYVVFERLGMMAEKLGWGRLRAEKWKRSVTLVLNLWEGWCVFPVESHALFVSAFENPPSLKSQEKADESVKKGKWKIVEANQTAATASEAAATDKAALDGNAGGRPVPEDEVIGEPIEEEEVVGEPIEEEDVDGEPIDDDDDDVVGEPMEEDDDQDAGTDASNAPEPDAQAKPPSTGRSQPRRRMRAADMFADSDHSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8E9</accession>
    <name>A0A2T4C8E9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1224603</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C8E9"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="72"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="525" mass="56879" checksum="790499F5D57D1E57" modified="2018-07-18" version="1">MTVTHTSNVGPLTVLVSTRAVLTLPDNSLVLCPATICISPELGKIVSVVPEILPASAFPPSATYVDHSPKLLLPGLVDAHVHLNEPGRTEWEGFWTGTRAAASGGVTTVIDMPLNAIPPTTTLQGFEEKLRASHGQCWVDVGFYGGVIPGNADQLKPLVEAGVRGFKGFLIESGVDEFPAVSAQDVALAMETLKDEPTTLMFHAEMIPPITDSVGDAVQTSDPPAAPKGELTAYSTFLQSRPPSFETYAIEEILAHAHIAPSLHLHIVHLSATQAIPILKAARQRGVNITAETCFHYLGLTAEEIEKGDTRHKCCPPIREANNRDGLWEELVAEDSCIRTVVSDHSPCTPQLKLLPSHLERPAMLHKDSGLDMVDPKEEAPTRTIARGDFFAAWGGISSVGLGLPILHTAAKQRSETSKVPTIVDMVRLCCQATAAQVGLSHRKGALKVGMDADICVFDDSHVWTFTQGDMRWKNRCSPWQGHKFTGRVKETWLRGRKVFDLEAPGDGFVVGKPFGEPITEKRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8J1</accession>
    <name>A0A2T4C8J1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1375462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C8J1"/>
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23089" checksum="6ED1D4093ABCABAA" modified="2018-07-18" version="1">MASTEAAQLPPAATRQSNFEQAVACALHLWPALTLAVQNGWGGPDSADKRDWFAGAVVDLFPEFADAQPGEAPKTTADEPDMEDVETVLLQVMVDEFEVNIDDDSALEVARSIVKARSECAIGEFNEEVKKLRERFANRKGTKVDQMFKKAEDQDQDTDWESGDSGEEDDDDNGGDIDMDEAPPLVSVPKEKPAPEVDDDGFTKVTRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8L5</accession>
    <name>A0A2T4C8L5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8L5"/>
    <dbReference type="STRING" id="983965.A0A2T4C8L5"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="142" mass="14970" checksum="9E109094B7D745B7" modified="2018-07-18" version="1">MASTIRNLAHIPLRRSCVTATALPRQYHTTAALRLPYKNSQDRQTLKPGTNEGTRSGRDEDVAAQKDAAFNPSKTDPESEKEAAGRGNETNPLNASGANQEFNKPMGDTTKAQDTGPGKETSKGGRSGGGSPPKKGKPPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8U5</accession>
    <name>A0A2T4C8U5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1329196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8U5"/>
    <dbReference type="STRING" id="983965.A0A2T4C8U5"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="380" mass="42668" checksum="A796557EFCC08F27" modified="2018-07-18" version="1">MPPKKEKPAAGKKPSAAKMVEDRTFGMKNKKGAQAQRQIQQMTANLKGSGSAEERRKAAEKAQREKEKKAAEDAKRETEALLNKPAQIQKVPFGVDPKTVVCIFYKKGDCEKGKKCKFSHDLALERKTEKKNLYTDVRQEEDEKKKQETSADWTEEQLLKVVLSKKGNQKTTTDKVCKYFIQAIEDGKYGWFWICPNGGDKCMYKHALPPGFVLKTKEQRAAEKALLDKSPLKTLTLEDFLESERHKLTGKLTPVTPETFAKWKKERLDKKAAEEQARKAKDNTGRALFESGKWNDVDSEAESDDEDDDTWNLEKLRRETEALRLKKEEERLATLHGGQVPTSTSDTPEEEGGSDEGNGEAAGTAKEASVAQTSQEVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8V7</accession>
    <name>A0A2T4C8V7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1468599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8V7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="13274" checksum="2C9557CCCC61A6B7" modified="2018-07-18" version="1" fragment="single">LTHTHSRSHTPAQPGIQSQYLFSGFVFNARLPSSSFLSNSFSLLFFFFFFLSQASSSSSPQFVLILVLVLVRPSVRLSSLFPAPLANRPSTVRLSQPPSIRVSPRPRQLINRRKQKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C943</accession>
    <name>A0A2T4C943_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1468614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C943"/>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="507" mass="53228" checksum="AF8AFB839320E841" modified="2018-07-18" version="1">MSGLTMIQGPLSSSLHAPTSAQSLTTSYLIAMSSLLPLLGRLTAVLSPRAIVLPSAALFSLGSLLASQATSYAVFLAARIVTGVGGAGIVVMAVVFVIELTGARTRGVAIGFVNAAFTMGVSVGAAVYGVLEPVAGWRPLFWFPSPIVFLAGISLHLSLPASMSLPPAEQPGKPASLRQRLAGIDYLGASLLTLTIVLFLHSLSTTIHPLPLLTSLLTLTLFALAESRSNDPIIPLPVLTSRPILLSCLAQLGLMSARWTILFYAPISMLSLRAASPAEAGSLLIATNIGFSLGGLAIGWLHVRRQGSFYRAQLLSQLAFALTVLVSSILTPLICSPSYSSRAPFAAFVTTICLNGIITGISLNYALVHVLHLSHPSTSYVTTSLIATFRGFGGSFGTSLGGGIFIRVLRTRLIAGFLSLDCDDELSPRRRKMVDELLGSPQLVWEEGFLGEREREVAMGGYADAIGSVWRAAACLGVVVVVVQAAAGWTAPGEGEGEERTLQEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9L3</accession>
    <name>A0A2T4C9L3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_17837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9L3"/>
    <dbReference type="STRING" id="983965.A0A2T4C9L3"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="378" mass="41876" checksum="38A4098E7A3CFF87" modified="2018-07-18" version="1">MSNPLPSMPAGAIPVDASSSSTWDRISSWVSEHKAVVYTIAGVAVVVTGAGVVYYLNNDSGLEQKTAEGYEEARQAFEKAIELGDLGEHEALAYNLRGTMRTLMGHHTEATQDFDRSIELDPKMTQSYIKRASIFLELGEPDKADAEFAKALEHDSEDPDVYYHRAQAHFIKGDLASAQKDYQKSIDLDKDFIFSHIQLGVTQYKMGSIASSMATFRRCIKNFPKVPDVYNYYGELLLDQGNFAEAIEKFDTAMEMEKQSKPMSMNVLPLINKALALFQSSQDFKEAEKLCQKALIIDPECDIAVATMAQLLLQQNKVTEALKYFERAAELARTEGEIVNALSYAEATRTQVKVTEKYPKLAEKLAGGPGGPAGLRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Q5</accession>
    <name>A0A2T4C9Q5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">M440DRAFT_1328087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Q5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9Q5"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="244" mass="27306" checksum="E4E853738A50CB24" modified="2018-07-18" version="1">MSSTRCLARQATSLSRRLLVQAPSRPLSTSAALRATTAPSSEKPSAELPKKKLKPLTQEQRDFLSSALRVNQAGELAATLIYSSQTPVITRKHPHLRPLMAHMYDQEAAHLTTFNDLIHKHRVRPTALYPLWSVLASGLGWSTAVMGREAAMACTEAVETEIGSHYNEQIRSILEMITQWEAQGYDVSGEIKQLVDTLRRIRDEELEHLDHAVENDAKKAEPHWLLTNVIRAGCRGAIWVSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAA1</accession>
    <name>A0A2T4CAA1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1390158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAA1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28807" checksum="0BBD9DB11A50523C" modified="2018-07-18" version="1">MCAFFLVGGGYGAMLTSTLLACIAAVDHSQQAVITSATYLARSLGGTIGVTVSSAVYQNVLKDRLWKRFGDEPHAAEIIQKIRDDLNFLKHLPPGWHDGVLDSFMEAFRGVWFTMLALAIGALICNPRCRLEELTWAPELTFTTRYSIRDALAPTDGLRHYVWNRVRDAIDSSGPPQRTATALLALLGPPLQVEKDCWDTLDRGERELSYKDLKDTIDSNTPPEGGQAYPFQIDRSLPKKNEERRTHFFVVDVGYTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAB2</accession>
    <name>A0A2T4CAB2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1194753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAB2"/>
    <dbReference type="STRING" id="983965.A0A2T4CAB2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="492" mass="53564" checksum="4A142987912FE5B7" modified="2018-07-18" version="1">MAPAATSPPPTTKSQTIDLQSNYVQIINGKSAPTEHVRHGINPASLKPKPDVPVATQADLDRAVDAAKAAFKKWSRVPYEERRTAVLAFADAIDAQRTEFRDLLISEQGKPIPQADGETDAAIEWIRGMSNIKLPEDVIEDDDRHTVTTRYTPLGVVAAIVPWNFPLLLATGKIAPALLTGNVIIVKPSPFTPYCGLKVVELAQQFFPPGVVQSLSGDDNLGPWLTSHPGINKISFTGSTATGKLVMQSASKTLKRVTLELGGNDPAIILPDVDVDKVAEKVALYAFLNSGQVCLNLKRIYVHDDIYERFRDAMVGHVRAYTLGDGAQPGVTHGPLQNGMQYERVKTFFDDIERQGWKVAVGGKMEAPERGYYVAPTVIDRPPEDSRIVVEEPFGPIVPLLSWSSEEDVIARANNTSMGLGASVWSNDIDKAARIGRELEAGTVWINTHFEISPNVPFGGHKESGIGAEWGINGLKSFCNVQSMFVNKHVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAM0</accession>
    <name>A0A2T4CAM0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1352110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAM0"/>
    <dbReference type="STRING" id="983965.A0A2T4CAM0"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="868"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="756"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1163" mass="126607" checksum="4F6464A08DB29DE4" modified="2018-07-18" version="1">MSPSRPLTRADQLLLEETVESQDSQLILEALKAEFRPAAQFDETLASQPPAGIESQSEIVGGGVGDALGDVHADDGGPRRRGPQWDGLENQRQLAPQEAVATAHGDVNNFTGSTHRVGRDAPRPRPPPARPGLRERDSEDAVIAASSPFNRNARSSTSPHNDDTRTANDKPPPALLNGAKEMDTSQYTPTQENTEQDYGQFYRPPESSPPPDTLPLHDEPEKTLQADDTGAVDFGHLSPGVRPSSQVSEDAGFENTRGEWRAPDLTSQQRSSHGFTPLKPGVRLPETPLPAKNPFAMQNNGGAGVPFAGTQLFEQTPAVTSAIKLHSPTSSRPSPAMLPDTISLNLMPTSPLKRRDNVSSPTVLHTSSPSRLTTVAGTTRKPRVSPIREEVINEDEDGDPHDDMIPESPTIQPLKSFGNRQPPAQVQSYYEPMKKSQERKAIVRAPPKDPGIDSDSDDAVIRMRRKKRMDRIRLQAAEEMEKVRVPIPSRQDSGEGRNRKRRKLSSGGEEESRSPKPSAPDHPQHAKAATGSHSPQKGSSLPEQSLSAGSTKATPRDVTSGEGSTKTRAVRSGRRDKESASEDMIPATSPVRSLSAMAQRGAPLASEPELPTLNEKEAEDEGAGNDVESSSLPPPRRHVQRVYGRHAQSRRRNRVIASSETNERSSVEPEQQGRKGGLTSSSDAAPVANSEPVPRVSVEHGEQMEAGNTEPELPKLPPTRSHSAATVATSLLTERSERTPLTPVRAREADRRHHASSSITAISTPVVSDKTTPDTQATPGSDQPKPTTSLSSPAQNCKMRTRNPERISREKTPQGAVKAAKASMPSAGVNPTSTDELQQSPPSSALEMGISSLRSSRIFKQSIGSTFRGRRLFEGMVFAISLSPDKESQKTRANLETKIKQAGGHILESGFEELFEPSSLMSTHEVPTAANGAPLALSKASLYYGFTALIADKHSRKVKYMQALALGLPCLAYQWIITCLNKGMLIDWEPYLLAAGSSAVLGNAVRSRCLRRYDVAEARLAEMVEHRPKLLAGEKLLALVDDSRTRSEGKKKKTDLEKRPYMFLAQALGPSISWVSTIQQARELLDAQEKAGEPFTWLYMDDSIGTVESVLTVSESTGKKRRRSQAPSVMRNIRVLCDELMIQSLILGRMMEEDELIYVGEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAS3</accession>
    <name>A0A2T4CAS3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1352313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CAS3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1202"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1230"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="478"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="706"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1408"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="954"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1532"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1541"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB78669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1700" mass="187523" checksum="F95D2BEA3B5A3B96" modified="2018-07-18" version="1">MGFAQCSWPFWRIDDFTLCFQKNYLAVLFPLIVIGISFLQLAFSNIGRLRNGKSKGYSSISADDTVPNHTDIPSDEQPEDSDDDSSDLEINGGRLALAKVTSRGSIVQADTPTGQRLSQFIEELALAGLVAINAYALVTGAFGPDTHLVAIAGLTTWLYTLILATLRVALGTSKWRIPRIWNHTATIYGCNWVLTVFLFRSAIIHPYSKLSQSLISAVFALNTLLFAIAACTRKGNKTVVLEWEDGIEPSREPLASLFSIASFAWVDAIVWQGWRRPLELEDVWNLLPKDKSAAVIANYRLAKKTTALSWHLLKYFRKQLFMQCLLAAIAGVFTFAPTLLLKAILQYVEHPEFAPVSVLWLFVIALPVLDTIRSYCDGMALWIGRKICINVRAIMVGDIYAKALRRKAAAGKDKVLLGEKAKSNNDQGDESKGRGLTGKVKHALGLGGKKQKNAVAADDAEAANAASKATEVKIGADEQANLGTIINLMSVDSFKIAEITAYLHFLCASAPTQLTVSVFLLWQLMGLSAIPGIVVMAFLLPVNYMLARGFNQTSKNIMAATDKRINVTSELLQNIRIIKFFAWERRFGKIVDEKRQAELKALRSRFLLWALAVAIWNSVPVLITFFSFLVYTLIEKKPLYPSVAFTAISLFMLLRVPLDLIGDMFAHVQEAKVSIDRVEEYLAEEETEKYEQLGLDNVDETGKKRIGFRDATLIWGGKDNVAEDGSKAFRLLDLDIDFQIGKLNIIAGPTGSGKSSMLMGLLGEMTLVEGRVFCPGGRSREDVRPDPETGLADTVAYVAQAAWLFNANIKDNIIFAAPYDEQRYNDVIVACALQRDLEILDNGDETLVGEKGISLSGGQKQRISLARALYSNSAHLLLDDCLSAVDSHTAQWIFTNCINGPLMKGRTCILVTHNVQLCVPSSDYVVVLENGRVTAQGPSQEVIASGKLGEEIQRSRPASHVASRVPSRVPSSVGDEETMLNGNGNGNAADGSKQDKKAEASKALSEETVATGAVKWSVLKTYLSSMGPWWFWVVALMVFGMQQLSTVATNIWVREWANQYIEEETANVSFSTFSHVYGAASFLKGSWASVATLGNDVQSFVQPAPDILDIPQDFLQPRPTTAPQVNVAYYLGGLALIGAIGAIAALIRDVWIFFGSLTASRSIHDRFINSVTRAKFKFFDVTPHGRLMNRFSKDLEAVDQEIAPTAIGMMTCGLSLIVTIVLIAIITPRFLIAAFFIAILFYIVAAFYLRASRALKRLESVQRSPLFQQFSETLSGMTTIRAYGDERRFIRDNLAKINLQSRPFIYLWACNRWLAFRADLLGNLVSFFAGVFIIKNLGKIDAGAAGISLSYALNFTENVLWLVRQYGMNEQNMNAMERVKEYLDVEQEAPAIIEDCRPPENWPAEGGVEFVNYTARYRAELDPVLKGISLKINPKEKVGIVGRTGAGKSSLTLAIFRALEADSGSIIIDGIDISKIGLQDLRENITIVPQDPTLFMGTIRTNLDPFDQYTDEQVFEALRRVRLIGEDEAVSPTTPTVQVTAEGESSGASSGTRTPSIATNKNIFLDLSSPVSESGSNLSQGQRQLLCLARAMLKKPTVLVMDEATASIDYNTDSKIQKTIRELTGTVITIAHRLQTIVDYDKVLVLDKGEVVEFDHPWKLINQKDGTFRSMCQTSGDMDTLLLAAMKKWDSGREEREAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB72</accession>
    <name>A0A2T4CB72_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1327739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB72"/>
    <dbReference type="STRING" id="983965.A0A2T4CB72"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28992" checksum="6DF2534AE69E315C" modified="2018-07-18" version="1">MGGVPSIPTDRSRTVQVIGAGYSRTGTVSMALALEKLLGGPVMHGGTQLFGREDAYVKLWCDVFANRDNRPVLLKLLREATAGFVAVTDAPANAFLPELLELYPEAKVVLVTRDPDRWFNSMQGLIKDGIGESMLMLKVLLWPCPGWRWTPLVLDQLGSYEATRIGSTLTRDSILIHNEWVRKHVPPERLLTMELSQGWEPLAKFLDMPVPDGPLPHANDGEAMEKFAKSVFRTAMLIWVGILSGTGMLAWVGVGAWRRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB77</accession>
    <name>A0A2T4CB77_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1420864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB77"/>
    <dbReference type="STRING" id="983965.A0A2T4CB77"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="28422" checksum="7D859FB00D49F382" modified="2018-07-18" version="1">MSYCPTNEDLEFSSLRCSFCLQLCHATPNFKPPDEQASEWLVSRYGRDVNPYDELASNAPCGLCALYARAWTRLELAICDQEVDDSRAVPYCLADAAGFGACLPLFGCTIGSLQYAVRSYFGINGTKKQDCADGCCAPLVTLVRNEQEIILRQNLRKASRKEQAKQYVYSDPMVYPAAKLAPRAVRAVQGSANEVTARGTNARAQSPYEEAPQPPKGNRRVHDLEDDLTAPKSGHGEEERTRTPRPPKSVPQGLGATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBJ0</accession>
    <name>A0A2T4CBJ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1373932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBJ0"/>
    <dbReference type="STRING" id="983965.A0A2T4CBJ0"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="276" mass="29848" checksum="4D9864455271A598" modified="2018-07-18" version="1">MSSSTTFARHPPEVKIARISFPAPRVLLVTISRPKALNAIDISGSWELASLFEWFDEEPSLWVSIVTGEGRTFSAGADLKAWNDEIGSGSFGEMPSSGFAGLSRRTGKKPVIAAVNGIAYGGGFEAVVNCDLVIASATAKFCFPEVKRGVAPFAGAMPRLVRTIGKQRAMELMLTGRVLPAQEAKDWALVNVVCPEGQDVVDEALRWAKTIAEHSPDSVIVTKQGINWGWEGVGADEGTRISNSLWHHKLLAGDNIKEGLKAFVEKRSPKWTDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBX2</accession>
    <name>A0A2T4CBX2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1398289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBX2"/>
    <dbReference type="STRING" id="983965.A0A2T4CBX2"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67566" checksum="32FC3DCACA1DA938" modified="2018-07-18" version="1">MLVAAFLRNGLGLLVPLAIACTIYLYLYPFFGGCAFPLPSRDAREALEATKRLHWPFNRTDPDAESPADHVPTQLAPFRLLALGDPQLEGDTSIPTVILGTFPHAASIYRHVTFQTEHWCFRERLRWIAHDIVDILFEDIPYYLESWRKRLDHIGNDFYLAHIYRTMHWWTRPTHVSVLGDLLGSQWIEDEEFDRRGQRFWHRVFRGGERVPDEVAAWPAHEYDLAGMLDGSDEEQVWTRRIINVAGNHDIGYAGDLTKERLDRFERVFGKVNYELRFGIPLNDSAVLATIHDEQRNPESNRLDPEIRIVVLNDMNLDTPAKDTSLQDATYNFINTVIGTSAAVEYEGIFTLVLTHIPLYKPEGVCVDAPFFDFHGEEDGSGVKEQYLLSADASKGFLEGFFGMNKDPNAAGGGRGRKGLILNGHDHEGCDTWHFINQTNGTDPSERAWEVARWRDAQARGLPKLTTSGVPGRREITVRSMMGDFSGNAGLLSMWFNPETWEWEYEFANCRLGTQHFWWFVHILDFGVIVVFVVYVVIRMLEIVGVDVDARFLRVAALFTPWWFRKSDDEAVVQNGRFDALMGDGHVWIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC26</accession>
    <name>A0A2T4CC26_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FYVE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1468056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC26"/>
    <dbReference type="STRING" id="983965.A0A2T4CC26"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="322"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="579"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="655" mass="73809" checksum="4500DFB2E7C4B032" modified="2018-07-18" version="1">MRNTRTKCRSPSHKGVNSPSHPLHAILVVGRNPAQARPQLPNRLNGIPNVRRQLAGNVPPQRRRQPRPLAVGADHDLQRPVAVDAAKELPVEEQNEVKTWFDKQVLKAKRFQPLSMINLKLRGLEVFESNDSHPVVPPTIATSSAGKLPMEAPIDPEELITRSHWQRSTSYDVCTDPTCEKRLGPLNGSVNCRKCGRLFCEQHTMYQMKLSRSASHEPVRGYWARVCETCYKSREGYNDHNGLSVDHTDMFKAVRRKKVERHTLEVTRLEKRLTKLTRLLANSPEVLANASNGSLLAPVQSLTGQKNTRKLIEQSVVTWEEDDKVPECPFCHQEFRSWTFRRHHCRICGRVVCGDPQTGCSSEVSLSIAGPTGPGVEKPPSATSNGHIAVDIRMCKDCNDTIFSARDFAASLAYKPPDQRAYETLRQFERGIRQLLPSFHRALVALQPEVKENGEIDLNKPPATHAQIQEASKIRKRLIDSFTKYGSAARRLRDLKADNPTQQRLQLAVYAYASSFLHTNMLPLKNIPQMLRHRSTPSSSSSHSHFLPSTNHSTSSLRHSELAESDIASQAPSEASTVVSLLETEEKELKERLIVLEEQKFMVEEMVKSATGARRFEEVSALSRNLDELNGEIQGLRKRIGDVERKWEVAYRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC62</accession>
    <name>A0A2T4CC62_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_17106</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC62"/>
    <dbReference type="STRING" id="983965.A0A2T4CC62"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="769"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="852"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB79153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="901" mass="101340" checksum="1063990A687310E1" modified="2018-07-18" version="1">MYVRKRDGRQERVQFDKITARVSRLCYGLDTEHVDPVAITQKVISGVYGGVTTVQLDDLAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQWSAVVSDLYHYVNPKNNRASPMISKDTYECVMRHKEELDSAIVYDRDFNYQYFGFKTLERSYLLKLDGKIVERPQHMIMRVAVGIWGDDIERVLETYHLMSSKFFTHASPTLFNAGTPQAQLSSCFLVDMKDDSIEGIYDTLKTCAMISKMAGGIGLNVHRIRATGSYIAGTNGTSNGIIPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHADVFDFLDLRKNHGKEEVRARDLFLALWIPDLFMKRVEKNLDWTLMCPNECPGLADCYGEEFEALYEKYESEGRGRKTIRAQKLWYSILEAQTETGNPFMLYKDHCNRKSNQKNLGTIRSSNLCTEIIEYCAPDEVAVCNLASLALPAFVDYNEGCYDFKKLHEVTKVVVRNLNRIIDVNHYPVQEARNSNMRHRPIGVGVQGLADAFLALRLPFESPEARELNKQIFETIYHAALEASMEIAKIEGPYESFKGSPASEGILQYDMWDVKPSDLWEWDSLKEQIKEHGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYQRRVLAGEFQVVNPWLLKDLVDTGLWSDAMKNRIIAENGSIQNIPNIPEDIKALYKTVWEISQRQIVQMAADRGAFIDQSQSLNIHMKDPTMGKITSMHFTGWKLGLKTGMYYLRTQAAAAPIQFTVDQQALKVADTAVSKDRVLKKRAPPPGSSFMMSPPSAVPRPSSAKPEENSANSLSSNGVLTPSTTPPASRPLASPHKAPPMKADIEEGDSPKVLPTEPSDNVKDEELSKKPNQSEDKDEDSEERERDIYSDAVLACSIENPEACVMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC80</accession>
    <name>A0A2T4CC80_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_64274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC80"/>
    <dbReference type="STRING" id="983965.A0A2T4CC80"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="85"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="263" mass="29284" checksum="E958940927A480B3" modified="2018-07-18" version="1">MLIVTQEAQQPCQQHATLQCSSTLRTATSSQRTQRTMDPSPEAYEATHVHSVYNAIAPHFSSTRHKPWPLISSFLTSLPPGSVGLDVGCGNGKYLPVNPKLHILASDRSEALVRLARQEQKLVGPASPPQVVVADALSLPYRERSVDFVICVAVIHHLSTRERRREGIRALLDCVHGGGRVLVYAWALEQGSSRRGWDEGSEQDALVPWVMRSKGKPEATFQRYYHLYRKGELEEDVEAAGGKVLESGYEKDNWWVICSNNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDF3</accession>
    <name>A0A2T4CDF3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_242069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDF3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="23903" checksum="D3BAD439793950A7" modified="2018-07-18" version="1">MNDAAGGGNGHTVWYNNRRARDLQQGKNDYSHSQRCYNSRGKRFKLRRIERRNSRKQYEVNAAGFNRNRSLKGGAAPLRGPPAGCGPGQPPPTDFDRNFWIPSVHPSFSASPRGRFPIFFSPERNLLAAPPGISHRPTSRSPGRKPLARGQEPEAARGVRQLGRSCPARPVFFILLCYFWIQLINFRKWRGTKKGLVSVLDGIPLGITVAWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDX3</accession>
    <name>A0A2T4CDX3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_247930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDX3"/>
    <dbReference type="OrthoDB" id="5428255at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="18174" checksum="C22A49B14FA73F2C" modified="2018-07-18" version="1">MVREIMLWGSRVTGRMDGRLDGWTDGWTDGRQDGWTDWNSGLLLSFLVFSFYWWMPMSCVCKTQGEGEGSVSSDMFAYPHGNALKKALLGRVSGKPACHTNTNTDGAQQTRRCNKHGHGLAPIGERLRRRASPRRNGTNGWEWKGHPGGQSQAGYPWERTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE13</accession>
    <name>A0A2T4CE13_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1179816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE13"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="16853" checksum="5CB2ABB13E6EB7B9" modified="2018-07-18" version="1">MSAPLPPPENHLACLSTVFRTRQACHRHQEQSSLIVSWDRRPGLSFPKTKLDRPPPGNRQKPLGPTAIIKNGGKGGGGGQTGGVRMRGVRISFLLPRIVKETKSRARNQRFGYLSQVPAEIKPVPSLSQALCLFDKTTHSSPYCFRCSSSYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEE1</accession>
    <name>A0A2T4CEE1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1347413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEE1"/>
    <dbReference type="STRING" id="983965.A0A2T4CEE1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015368083" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="22"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="525" mass="55640" checksum="76AAF6845A116F0C" modified="2018-07-18" version="1" fragment="single">MRVSLERACTLLCSGAAVAAQSPVVNLGYATYQGSSSGGVNRFLGMRFAAAPTGDLRWKAPTRPPTVSGVQPATQFGPVCMAVNAGPSPQGQSEDCLFINVWAPSGAGPNSKLPVWIFIQGGGFESLASAGTDGSGAVANSGNNIVLVTLNYRVGIFGFLASSEIQANGVANAGLYDQQAALLWVQQHIAEFGGDPGHVVIHGQSAGAEAASLQLASFGGKSQGLFVGAMFESLPEITQPKVSEIQFQYDALVSNAGCSSSSDSLSCLRSLSTTALQQFNVPIAYPGRPNAPNYPYVPCVDGVFLQTNAYEAFQRGKFVKVPMLFGSVTDEGTTLGAPNASSPEEIETFFQDNYPRLTRQNTSAIIQQYPENIEPPFNGHADWFPAAELAYGDVLVACVGLNFGKYFVQAGQPIWTYRFNVLTQDNIANGVGVPHGFDLGAVFGGGFEDSDQTNVARLQGNYISFVRSLNPNTFAFSGSTSWPQWNGQAAGQRLVVNNNNTVVEAIPQAQMSRCAFWESLAAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEH7</accession>
    <name>A0A2T4CEH7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1106899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEH7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="197" mass="22172" checksum="2F79DF87A580E5F6" modified="2018-07-18" version="1">MVQGYPRSTPSRTLVSAGCDNCGVASRLCHTTHEERQTRPKRASSRILHRQALRREKENGKDGHGWESKDALRDSWGMELSTSCQSSVPPLFLERRLVLQWLQCLIHHISDLPNLADSCASSMEKCDPHRLINDRDALVGPRQKHTTTLHASHSHTFVFAPCHGSAPMHERLLKGRVTGEGRQHAEAMKMAMAERQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEI0</accession>
    <name>A0A2T4CEI0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-terminal binuclear Zn cluster-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1397225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEI0"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF3">
        <property type="entry name" value="PROTEIN RDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB79942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="577" mass="65373" checksum="14E122B991A17B92" modified="2018-07-18" version="1">MEQLQDSDQDQDQDQDQDTLSPAPGSQAAAQPPQQAKPAQKGRIRAKKACIECRRRKRKCDGVFPCSMCTHYQYNCGFDGEIVTRGLQQKRPYDALLESGEGSQYVISETPEEASRPSTLVRGIIEPAKRRYMNQNSAVAFPNQLGVELESAHPPRLHSFAWNCGIRPEEPGSIHAPLTDYVTWEECRHYTDIYFATVGVPFHLFDKDKFLQQCDTYFNRRNQDLILGALIGAVVSLGSLFAFRDGHHLEPQIVKHVKDVLEDSTFSRRPSIDQVNAWILRTLYLRSTTRPHLTWLASCTVMHLVEAVGLHRDLESDLVTQSGETRAREDEGSKRTFWLAWCINTIIAYEYGRTKIHFDGEDSRPTPFNDTSETGLQIRMARILPSENVNADAITVSKSLEGAIQKLVDLGDVRGFPALTRGDLCFCLYRRLRLLKISISKDTLAHILQIGQNAVEAAYDLAQRGVPWWNVLGTTFQFFCVLLAIDNRDSLTQVSWVLSRLDGIVQILNTHMAFEAFETAKTLMRDLLVKKRQEVALLEMSEGSDIPFSNRELTPDWDMMLNPFYAVGGFNFKDFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEL1</accession>
    <name>A0A2T4CEL1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEL1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="87" mass="9217" checksum="8E07BD2EC7C54D08" modified="2018-07-18" version="1">MPSAHLPPGKLSPTRRVASAGGSAGPFFAWRRLVVTVVVAHDTSTNRRHAASDMVSVVPGVEAVNEPVFFSGEEAAMFEVDDLILAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFA5</accession>
    <name>A0A2T4CFA5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1460219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFA5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="200" mass="22103" checksum="E7ED85B170F12568" modified="2018-07-18" version="1">MALSVQCLCACTVQRILHCIAARPSQTCKHLETCSDLSPKGTLDRAHLMLTPCLAGHIERQEMQVKTHWTSIASSKAEQTGTTRDVIIDDVYERYAHSPTGPLGLIAQNFTTQPTGSTTPRLKYGDSYQRRHTRQDTKKMEASECMRQLAEVAIRCLAIAYTYLTMSEGANHHSSLHELKPGVGHKPIDCISPRPLGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG20</accession>
    <name>A0A2T4CG20_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1397886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG20"/>
    <dbReference type="STRING" id="983965.A0A2T4CG20"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="88" mass="10014" checksum="493F37B7966EC4DD" modified="2018-07-18" version="1">MRFSDTGAKIIVTQSKPSDFPSFLRQKLQSSVQSVERHTLNTESTVRERCPNCGREEVKYTTVQLRSADEGSTVIYNCECGNSWHENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGN4</accession>
    <name>A0A2T4CGN4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1324962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGN4"/>
    <dbReference type="STRING" id="983965.A0A2T4CGN4"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="303"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="602" mass="67769" checksum="458B0892B707E877" modified="2018-07-18" version="1">MHIRDLVADTEKSGAPSFSFEYFPPKTAQGVQNLYDRMDRMNNFGPKFIDITWGAGGGIAELTCEMVVQAQAVYGLETCMHLTCTDMGLEKVNDALQKAYKAGCTNILALRGDPPRDQASWKAADGNFQYARDLVKHIRDTYGDHFDIGVAGYPEGCDDNKDEDQLLDHLKEKVDMGAGFIVTQMFYDADNFIRWVGRVRERGITVPILPGIMPIATYASFLRRAKHMQCRIPPDWMAKLEPVKNDDVAVREIGKTLVADLCRKLLANGIHHLHFYTMNLAQATRMVLDELNWTPSPERPLKQALPWKQSKGFGRRDEDVRPIFWRNRNKSYVIRTQDWDEFPNGRWGDSRSPAFGELDAYGIGLTGTNESNRKKWGEPKSVQDIATTFVQYLEKKIETLPWSESALSAEADPIKDDLVALNKRGLLTINSQPAVDGAKSNHPVHGWGPSNGYVYQKAYLELLMPPYLLEEMIRRLDDFPNLTYYAVTKNGELKSNAPSDGPNAVTWGVFPGKEIVQPTIVESVSFLAWRDEAFRLGVDWAHCFDAGTPSRALIEDIMNNWYLVNIVNNDFRENNTIFALLEGLEVKDLAVPAGTTSVSDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGX7</accession>
    <name>A0A2T4CGX7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1136070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGX7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015563726" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9690" checksum="5496A8165D60F185" modified="2018-07-18" version="1">MMLRTLAICVVESLLDASVHTERACNGRDLTSNCRYLYLCLLISPRSLSLWETHHATRESHHFGIRQNRRIRRFIFISVCATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGY3</accession>
    <name>A0A2T4CGY3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1428408</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGY3"/>
    <dbReference type="STRING" id="983965.A0A2T4CGY3"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="169"/>
            <end position="242"/>
        </location>
    </feature>
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            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
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            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="242" mass="26743" checksum="541BE37767A1F30C" modified="2018-07-18" version="1">MASEMPISTVYVHNLEERVKPEVLTEALKTIFSEFGNVVDIVAKRNLKAKGQAFVVFDEPSAAHNAIEEVEGFELFGKPMRVAMARMQSDKTVELKGSSEDLDAHKRHRQAEKDKRKALEAADEQRQLKRAAAGAPEARPSKSVKPSGLKSTSAPASAVVPDEYLPPNKILFVQNVPDEYDADGLTAIFGRFDGFREIRLVPGRRGIAFVEYENEQGAITAKENTAGMTLGDKPIKVTYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH80</accession>
    <name>A0A2T4CH80_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">M440DRAFT_70675</name>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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            <end position="83"/>
        </location>
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            <begin position="86"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="99" mass="11084" checksum="7A084E2BD18E43EF" modified="2018-07-18" version="1">MTVTPRLQMRKDLSGPAPGKAFRFLYVVWLAPGLHQAISTLVSHGSGADCERRVIGRWMQRHCENEQGLESIYSRSLTNPQGSGSDGREKQWREKDGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHA1</accession>
    <name>A0A2T4CHA1_TRILO</name>
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        <recommendedName>
            <fullName evidence="6">OPA3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">M440DRAFT_1434870</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
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                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the OPA3 family.</text>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
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    </dbReference>
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        <location>
            <begin position="55"/>
            <end position="88"/>
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    </feature>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23778" checksum="35B13D07C8416B8F" modified="2018-07-18" version="1">MVPLPLFKLAALFNRIKAQAHDHPRFRALAAKYGQAIHQLNMKLSVALLRDPEAERRAREQAEAPTVKTEEQVKREEEKAKSKKSQQPNYPRFTLQSVWKRKFRPLPENKAVDLFADVAGDTFILGVAGALIIYEYYKSSQKPDANKERIDELNRRFEELQKKEEELAQAEERQRQRFESLEEALKSLKDPKTKQPLLPLLQANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHE2</accession>
    <name>A0A2T4CHE2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1396114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHE2"/>
    <dbReference type="STRING" id="983965.A0A2T4CHE2"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="529"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="634"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="611"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="659"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="918" mass="100785" checksum="64CD514502819CAB" modified="2018-07-18" version="1">MSSIPQPGPEALVTVKVTYENTPRRVKMPLRDMVPHTLEDNIRLFLRIAPEDRIIIERYSDSAGSFVVLDPINVPVYKQLYRAAKAKSKLKLRVSTLQTQPKPTPKPATVEDEPEESVAETYETTDKTSPLESDESASANESATEMSMPFEATPSSATLLSGVELPLRTASSAQLETAEASKPEEETEVPLAQKLSAIFAAPAMDSAVFDQRSTYSSFDNFCAPRAAEPPAQPPVLPHPVITAAPFAVCCNNCEKTVSDVHYHCQTCDDGDFDLCQHCVDEAVSCYDDNHWLIKRTMVDGRLVASSTEKIEPKSQMKKQVEDLFKPAPVLPSIETPEKEETEALKAARLDKAPAVFSAKPTLEERTAAAVNAFAPHSVPFVGGAITRWSSLSNMRTCNCCVQELPEAEFLHCTTCEDYDLCHACFGKDAHGHHPKHSFIPAVTGSRIPDHIAIKMKAGRNQAHNAICDGCDKYITGVRHKCLDCPDWDYCDTCMLSAAVTHVSHRFVPIYEPLADAAAVAQPVHMGICCDGPLCSKNQGYPTYIRGVRYKCAVCHDLDFCASCEASPANEHNKTHPLIKFKTPVRHVSVTTTGEHQDGKRMPPMGDRSKNVPKSTETSTLGDSNTINRVQTVVDVKPEEPKMEETQVKQEPGPEPEPVVETKQEPSPEIKEEPKEEKVAEIAAPVDENDLRAVFLRDSVSDGTIMPPNHVFEQTWVLRNEGTTTWPAGCSVKFVGGDYMGHVDSAHPAGISELVSASESTVCYAPLAPGNEFPFTVLLRTPARAGQIISYWRLTTPSGFKFGHRLWCDVSVRMPPAEVPAAPAVPAVVEPKKEEDTQSGSVMIFPKLDKESPQASMHEEHQAESVAGTAAETDALTASGEEYDWDGSDDGFMTDEEYDILDASDEEYLTDRDSKRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHS2</accession>
    <name>A0A2T4CHS2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase kappa 1</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GST class-kappa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1396270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHS2"/>
    <dbReference type="STRING" id="983965.A0A2T4CHS2"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="7">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00083519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="235" mass="26186" checksum="19B265FC1D86921E" modified="2018-07-18" version="1">MGGKIECFLDISSYFSYVAFADLAQNRDKLAANGVDIEIHPVFLGGINNLSGNNPPWTNKAKANYLQHDSRRAAHRVGLVNVRSPPDLMAVGLTISPLRALHYIKANYPRDTFLAAMEACFIAFWTPPNVNLIPEENLRAVLQGATEKPGKSDSRKLFTEDEVERIMQSRGSMKDVLLATTKRAVDLGAFGAPWFWVTNGKGEQEPFFGSDRFNHIYKFLDVPFQDIALLTPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHT0</accession>
    <name>A0A2T4CHT0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 89 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1427094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHT0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHT0"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015451967" evidence="2">
        <location>
            <begin position="21"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="128"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="473"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="748" mass="84724" checksum="ABFAB3D1ED1C0436" modified="2018-07-18" version="1">MMRVLKACAWLLTAVGVAASSHQSPTEGVESLVKRRLPQHVDSFEFVLEPSHGSGLLNDTYTVSSTNNGKVRIEGTTTSALLSGLHKYLSGEANVDIWWFTGSQLHQAPKTLPKLKVPIKGSSVVPYRYYWNTVTTSYTSAFWSWEDWETQLDWMALRGVNLALAWIGVEKVFIDVFHEIGLNDEEIDSFISGPAFLAWNHFGNIQGSWGGSLPRSWVDEQFSLQLKIITRMQELGITPILPAFPGFVPRNISRVFPDISLSMSPVWSDFGTTLSADTYINPFDPRFAQLQKLFINKQQELYGNVTNFWTLDQFNENRPLSGDLDYLRNVSHNTWTALKAADPEAVWVMQAWLFSSDSSFWTNDRIEAFLGGIPDNSDMLLLDLFAESAPQWQRTDSFYGKPWIWCELHDYGGNMGLYGQIENVTINSVDAVRSSDSIVGFGLTMEGQEGNEIMYDLLLDQAWSPKPIDTETYFHDWVSARYSTEKIQSLYKGWEMLRPTVFNNTNMTVNAVQKSILELTPSISGLLGRTGHHGTTIMYDQAVMVDAWSELFKAGLQDLTLFKNPNYQYDLVDWTRQVLVNSFEDLYKDLVDAYNKSSSATVIRSRGAKLVSLLKTLDAVLATDENFQLAPWIEQARASDPSAADFFEFNARNQITLWGPQGQIEDYASKQWAGLVGTYYAERWQQFVDYLAATKPASYNQTAFHEKLLIWETAWGQQTSTRIVNVGVTDIRSVLDMALKSWGELFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHV6</accession>
    <name>A0A2T4CHV6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1008475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHV6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="15654" checksum="CE7054D1FE318255" modified="2018-07-18" version="1">MRPSMISYKYSRKKHRAFTSELFIKTESASFISSLSAINSLEQKPLKSHKPFISKIKPVKSTLTTKIEKPLANPICKPITPLNPQPPITRKLARTTHLKSPKISRPSVPLTDKKPRHTPQKKPEKQIEGFNTPPSLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHZ4</accession>
    <name>A0A2T4CHZ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1366995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHZ4"/>
    <dbReference type="STRING" id="983965.A0A2T4CHZ4"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="270" mass="29559" checksum="4DC7F335A022AA34" modified="2018-07-18" version="1">MAKPYPQVVLLGDSLFEFAAADLSGFSFQAALQTRLIRRFDVVNRGFSGWNTDNVVRYLPELFLEPSPAAPKLAYLIILLGANDAVLPLETTSQHVPLERYKENLNKIVNDARIRAHNPKILLVTPPPADEIKLKDLDMAQGHASAIRSSAVTASYAEAARQVARENPGVVLIDLWQAIMGEAISMAPGDYQPGGPWLGSYENGKQGGLDTLLPDGLHMGGAGYRVFFDELKAHIGQDIVPDERGDYVLPDWKVLNPPKVNLVSKPLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI25</accession>
    <name>A0A2T4CI25_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1417911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3RF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI25"/>
    <dbReference type="STRING" id="983965.A0A2T4CI25"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="866"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="928" mass="103557" checksum="DEECC5A840B7B50D" modified="2018-07-18" version="1">MASRTHGLDLGKELTCSICTELLYQPLTLLDCLHTYCGACLKEWFRFQAEKVGRARTPPPPDAIIFTCPSCRSSVRDTRHNATVATLLEMYTAANPNKERPEADKREMEEKYKPGDQVLPKVKTRERTAEEKRLEEEDRRLMEEVREMSLREAIEGATPESQQARSARRHADGRSSDGRARSGSEYRSDGHSQRARDGRGRTGQSNAEYLSAEGDSQSRSRRSESRQRQVEHQSSLRSLIGSEMSERDIEREIEEFARQIQEEGLLDGLDLDNIDLSRDDELSQRITEAYRRRQRGRSRQEQPERRPEARTQNSASSRDSRLRPDNVRPQSRHRAHSRSTSEVGDRHRPPISPSASLGVREPERRARRRTTSGGHHSTATPPINSSSLSSMDARPAAHSQNDLGLRREHSDFDPTASVPALRIGRSSSSTAIPAAAHPADTPPRGNGHGASFASRTQSYPSASTPSHSIPPELMEITAARNSKANRPAEVVSPPASVVSSPIESPMASASRHQRAQPQLFEEPSISCSRCQKADIQYDVHYNCRVCNDGHWNLCVDCYRSGKGCLYWFGFGYGAWKKWEKRKQTDETIAMPHMLNAGRYMRPASTTASADGKKAMTTDDPKSRLETGTFCARCFAWTNDCFWRCDVCNEGDWGFCNNCVNEGKSCSHRLLPLAHEATLKSSYVPRSPRSGGRPSTATPITASQLSGIGPFRPLTFKIKCGICKDNIPPSDSRYHCFSCSSTAVQDATPGDYDICTSCYSGLESKGDVSEENGSSGWRRCLSGHRMVVVGFMEGKLGQWRSVERDLVGGRALRSEPLENIAHPDYMKWSWYEGDGKRERLVTTDVSATAPDRLGEISYAREFPPDGGCGLTAHAMWAWYPKPGAEDELMFPRGADIQEIRDINGDWFFGTYMGAKGVFPAPYVKLPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI88</accession>
    <name>A0A2T4CI88_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI88"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="70" mass="7447" checksum="5A9ABB0AD2B6170A" modified="2018-07-18" version="1">MVLAGGPFVLDFSTRQRRVSVAVGMQRFLVCHWGSTLASLFSCTIRIAALGVVSAGVPKQDILVPPFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIW9</accession>
    <name>A0A2T4CIW9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCAAT-binding protein subunit HAP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_63387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIW9"/>
    <dbReference type="STRING" id="983965.A0A2T4CIW9"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000110">
        <property type="entry name" value="Nuclear factor Y, subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="22384" checksum="B9036ABDD3555CC7" modified="2018-07-18" version="1">MSDSPQSPPKDVDQGAQSPDEEGQMNDNQEPHSAGGTGYEFEGVKEQDRWLPIANVARIMKNALPDNAKIAKEAKECMQECVSEFISFITSEASEKCQQEKRKTVNGEDILFAMTSLGFENYAEALKVYLSKYREQQNQSNRDRVLENNTWGNAMIPGEKTEPGTTGPEYAPPEGANPPEGGAEPNYMYTSHAGHNGAGAGENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ55</accession>
    <name>A0A2T4CJ55_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1444024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ55"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ55"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="8">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="375" mass="40606" checksum="471677F9AEF04AF8" modified="2018-07-18" version="1">MGGKSANKAGYFDKLKGLLQDYKSIFIVEIDNVSSQQMHEIRHSLRGKGVVLMGKNTMVRRALRTFLVDTPEYERILPFVKGNVGFVFTNGDLKEIRDQLLANRVAAPARAGAVAPVDVWVPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLIDAGNKVGPSEASLLNLLNISPFTYGMGIAQVYDQGQTFPPSILDIGEEQLLKALSTAITTVATISLAINFPTLPSVMHSLVNSYKKVLAVAVETDYSWPEIEQLKDRIANPDAYAAAAPAAAAGGAAAATEAAPAEEKKDESEEEDEEGFGGLLYVTPFESQLRKPMLTRFIATKCLQSITGRLSGLIRFVSRFMDLNSRVHRSLVGRLRTNAMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ62</accession>
    <name>A0A2T4CJ62_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_88141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ62"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="18395" checksum="CF78BA037505554E" modified="2018-07-18" version="1">MMQANWVKAKPARGSRGKFDDVIFLKRLMVHLAGIPHYSDEAALEKFRPRAALAVWVAGLGEVCCLSTKYEREYVHSVKQLRTIGFYSLVVGKIYGEEYLEITCDHWYENVYGELGYNKMKQTVNVTYCQSDNVQHGASTGPHLVTVFLRNIVYYLQRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPF5</accession>
    <name>A0A2T4BPF5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1152956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPF5"/>
    <dbReference type="STRING" id="983965.A0A2T4BPF5"/>
    <dbReference type="OrthoDB" id="5384459at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="397"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="714" mass="77285" checksum="DE433D5877D5FACF" modified="2018-07-18" version="1">MDPFKGNPSEFNRKPVQQRSPRHSVEDSEDQYSYDLAEATVADGFRPTNLPPTDISSSSSTPNDPALASPDSSQARLLTLEPSHQQPATSAASKPPPSTPGRPSSAIKPPRPHDSLTLRNDGSNPLQTGPSLSSSADMPHIPPQGPYQGPSSASHPYQMYLQRTLSDATASANQPASRNSYDGPRGPAHPYALYPQNIVTTGDETPHQIPVGFTTSGHGYQRQLGPDGEEAGALVGPLGHTEELPPYTRYPEHGIVSKTPAAVATAAVAEDGMAGTESPTTGTIAGAGGIGVATRNPEFSSTEEDLQPSQSRPSTRSRHDINTAAQSSAEKAPATKWQQVAKRKLWGIVPYWAICMLFIGVLLIGIILGAVIGSVLSRHKPRPSGSPSGNYPAPTPTPAPDVIPLSGVPFSLPRLPVGNYAMPPLTPNQSPNACLSDHTQLAAWSCSLPYSYYQVNVDVSSKQKDTACYNLSLKAINPADAELLWGTQPPNLYSKAMILVNDTQEPRRGPAWWLQVTYDKVVVVEENAFPAKVKRWSSLGRPTVADYDVIRSKSSASVGAKDGDKPWICTWPDTTLEVFVYPIQNSTSPQPMPTATTSSAPNPYPTDGFHPYPKSMKFIERRIVDDAPKAYCRQVQVYNQGRSMKNLTDSLGNPIVVDIEEDLNSDPDSQRAAYPVKRDRRSRRSWSEHWVTQQAVELTPCGCVWWSPTVTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPI6</accession>
    <name>A0A2T4BPI6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1434666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPI6"/>
    <dbReference type="STRING" id="983965.A0A2T4BPI6"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="508" mass="57579" checksum="7A6395E50CB07664" modified="2018-07-18" version="1">MERHKQAVTKIAGAVRGYFERGEPYRIFHGSTNSTRPRPGPGHRAVDISSLGNVLAVDRGARTALVEPNVPMDRLVEATLRHGLVPPVVMEFPGITAGGGFAGTAGESSSFRHGFFNDTVNYVEMVLGNGDVVRASPHERADLFRGAAGAVGTLGITTLMELNLVEARKYVRTAYHRTHSVAEAVARVKAETQDPRNDYVDGILFSPDHGVVITGQMTDDKPAGQQAQTFSHARDPWFYLHVQDKTRQVSPSNNEPPVTDYIPLAEYLFRYDRAGFWVGAQGFTYFKYVPFSDFWRWFLDDFMHTRMLYRALHASGESARFVVQDLAVPYDRAAEFVDYTAAEFGIWPLWLCPLPATPNPTFHPTCQTDAVGADLVPQPMLNVGVWGWGPEDHDEFIAKNRALEDELVRLGGRKWLYAHTYYSEDEFWRVYDKDWYTALREKYSATTLPSVYDKVRIDVEASRRERREWKKSLKSRWPVGGLYGIWKSILSGDYHLHRNAGWKYKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPX1</accession>
    <name>A0A2T4BPX1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1451962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPX1"/>
    <dbReference type="OrthoDB" id="4878861at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="127" mass="13748" checksum="B48EA9C7D4DA29EB" modified="2018-07-18" version="1">MHSSIAVLPSALATAPQCGVRLVSSQGLTNWKQGRWDGFWAAREWLCNNTPCSDGDYTSPDGLTAAQTRVQPNIGCSAQSCWDNFEAIIDDCIDTANGHSTNGGQVNDYDGRAFYWISTNTVLENGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ95</accession>
    <name>A0A2T4BQ95_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1145632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ95"/>
    <dbReference type="OrthoDB" id="4899620at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="253" mass="29691" checksum="3DBE02C9901F3458" modified="2018-07-18" version="1">MCTSRLEVSDVRHPHSLPLPPSLLPPSHPKLNKPTRPRLSTFQLHGWLFSSSQYFAANLSMDDISFNPRDEAPDTLDLTQHVQRVVHWLAVNATAIGYASWHSLRWHLILSLAFQHVRICATMTPKEAHDRILDRLQQEYYPLRQSPAWCRLAIRALIVFRYIWLAAKMLFLELYLLDLAFWKLHRFARQRNIVPQITRTFSPGFHRLAVLAPLPPSRFRYVMAETVASIWYLWVRFFSIPLLAWMILISFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQE8</accession>
    <name>A0A2T4BQE8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glycosyltransferase family 24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1386578</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BQE8"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015729121" evidence="10">
        <location>
            <begin position="33"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="47"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="278"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="415"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="670"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1181"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1484"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB71533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1497" mass="167000" checksum="C022DCBE93DF3AE5" modified="2018-07-18" version="1">MLRPSSSPIMTQQRWWPWNLILGLLLALQAHSTPTVNVGMNAAFPAGPYLLELLETAAAENSSSYFPLLDRIAAGHFASASTDAALYAQVLDVLQKDGSLASPEALSTFKLALSLRSAAPRIEAHYQYYTTAVASAVDDAAESGCTNWVLLEGKQYCTPELDVVHREGLSSLRQAKDLPFDRTLGVGKEAVLYADPASSSFGEFHKALAKAARQGSLSYRLRYRRSETTHASDLPISGYGVELALKRTDYIVLDDRSHDEEAHAETLTSATSLDDDEDVSDIKPLASSDLSSLGLKAASFILQSDKPLDTLIKLTQDLPRFLTSIVAHNVSSQLDEELQSNSALGLPEGMNVLLVNGVQLIERQIEPFALIERLRQERRLIDGFRALGLSGKQAVSILGHQSVSLAKDSDEPLRYDWTDRLEDGRVLIWLNDLENDDAYEHYPKSITSLLQRAYPGQLPPIAKNIFTLVAPVDFSSSEDVSFVAQLLSFISRGIAVRFGLVPLTPTSEATTKAKMAYHILENYGVRGLIGYLGRLQQAASTLSNEGLFAEFTAGHELLEDSEKMTLAEVLEADTYQQQLKLAQQWTSRLKVDTPIRPTFFNGLSIPRDESWMQRLGMQIGEDLQTVQKGVFHGLLTDDDWAPGLFLSKAITRRNSYITPDDEKKSLRVLNINKIYKEHANLVEAIPVLEAAADSQRGDWAAVTVIADLTTTSGKELVLSALEFKRRNPSVRMDIIHNPTAAIGAASVTAALKANQGSLSGIQDIDELATLLQSQSEDSNNDEYLEALEQFLSASKIPSGARMIMLNGRLIGPISEDSEFDADDFQQFLEVERTKRILPVYAAIEELGLSDKLATPLDAARLTSITALSTISELPEGIFESTSSVRTTLYDKWQSTHSVIERGDEETASIFIVGLLNPVSEQGQRWAPILRVLSELEGVHLELFINPMAKVEELPVKRFFRYVLESQPSFSEDGGVRGLVATFKNLPSEALLTTAVDVPPAWLVAPLISVHDLDNIKLSAVKTAVHATYVLKHILIEGHSREGKGSAPRGAQLVLATEKDPLVTDTIVMSNLGFFQFKANPGVYSIRLKEGRNTEVYEIESIGAQGWNPVAGDNGTELALIDFQGVTLYPRLKRRAGMEMEDVLQEKEPSNNIVAKGLKLAEGFFGGRSNKKSLSAQEHAEINIFSVASGHLYERMLNIMILSVMRNTKHTVKFWFIEQFLSPSFKEFIPRMAQEYGFKYEMVSYKWPHWLRQQKEKQREIWGYKILFLDVLFPLSLDKVIFVDADQVVRTDMIELMNLDLEGAPYGFTPMCDSRTEMEGFRFWKQGYWANYLRGRPYHISALYVVDLRRFRELAAGDRLRQQYHSLSADPNSLANLDQDLPNHMQFHIPIHSLPQEWLWCETWCSDESLGQARTIDLCNNPLTKEPKLDRARRQIPEWTAYDEEIAALRQLFKKETGSAGKEKLLFDNGDSRTVESGGKNTKSRNLEGDKTHTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQH0</accession>
    <name>A0A2T4BQH0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1386589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQH0"/>
    <dbReference type="STRING" id="983965.A0A2T4BQH0"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43294" checksum="68392D59839893BE" modified="2018-07-18" version="1">MIHKPDAQHIEGIETARAASHAPATPAKLGDFSRLFAEFLDPLSLTSSSFTSSSEGSDYCSYDEGSSPALKATSLSSAASDRSSDHSLDDATHARHPNDASTKPSRTSAVAHGSPRAVKHIPAKAGGGNTGIASSPPSSAAAAAAHHSRSVANKPREKLRLKEDKHRALMMALVPYRVRDAAIAEKLPEVAAQGVHVFVDMSNIDIGFQSTLKEARHLDEHARLSPLPHLNLPFLTKILVRDRPVVALNVGCSTVPGRSEPRYVQQLRDLGYQIDLRERKRVVEVGLPLAGRPDTLRYVEDLVDETLQVRIAESVMEYFRTPGTIVLATGDAKPSPHSDGFFSCVQRALKMGWNVEVVSWRGNLSFRWVDKQWMSQWRDEFRVIQLDDFLEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR05</accession>
    <name>A0A2T4BR05_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_208520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR05"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="180" mass="19831" checksum="35784B112602FB38" modified="2018-07-18" version="1">MMMTLATHEDITRQKASRATLKPKRQMSSHNRLPDVPFGRAVGSFSLVRSTCTSSYPEILWRDLDGKESTSLMPPSLVPSIGFVSSCHRSRNSISRIRSSRFCLSDRLRLRSQSLRQAPDSTARHTISTRIAALQPRESRAARHPLTRSGLLASNGSHGMNSTMLTISVHSGGPLVGCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRG1</accession>
    <name>A0A2T4BRG1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1442391</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRG1"/>
    <dbReference type="STRING" id="983965.A0A2T4BRG1"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="435"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="136"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB71898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="595" mass="66249" checksum="B801260410FB907F" modified="2018-07-18" version="1">MTTTTSTSTSNHACSGSRGRICFRSGTTSGAATTSGEEEEAVKESRFLGTRRADSFQPRRGLSGRDGGGQVPYCSLASLRLAPACSPCPAAYTRLASQLAQRPVRNAASVERAALPSALSTPLRSSFLPVDLRVASAASQSRPLHVSSRRLQEDKVKTEAKPVEDKAEPKTKVEEEPTKDSEEKADGKEEAKEENKDEEAKEKKEDLPPPPPHGDKTPWQVFMETMNNELQKSQEWNESTKQIAASANQLAESESVRRAREAYEKSTGALAQTTSKVAKTTATAIGKGAAWTWETPVMKGVRKAANVTGDAVDKATKPIRETEAFKNVKNVIDDGSSSRYGGWVEKEERRKRREQLAKERGEDEVLQEDPNAGTNITLHKDAAWKEAWRDFRDSNKFVQNVFSLKGKYEESENPLITTARSITDTIGGFFAENETAMVIKKFRSMDPSFRTEPFLQELREYILPEVLDAYVKGDTEVLKQWLSAAQFSVYEALTKQYLQAGMKSDGRILDIRNVDILKARMLDPGEIPVFIITCRTQEVHVYRNAKTNELAAGMEDRVQQVTYAIGITRVPEDVNNPETRGWRLIEMQKSGRDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRL7</accession>
    <name>A0A2T4BRL7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1465945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRL7"/>
    <dbReference type="STRING" id="983965.A0A2T4BRL7"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="145"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="LYC1 C-terminal" evidence="3">
        <location>
            <begin position="276"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="458" mass="51816" checksum="2700D058DE829BA4" modified="2018-07-18" version="1">MGRPKGASTPLRAASDNVRCGGSSTQRGSGPRMDDSDESRTMSGIATPTSTRDDTPADGCDADDGLQEASDMASRLGKKFGLEDNPQPALDDAPRFTKGSKRELLIYYRRCAVYASSPLPAAYWSRIECMMRDYGNGLIECKEEFWYTRHCAEESTIYSGAIINSRPAIISTARGFKHVKGAVISQFYTAPERRRRGHGTQFLKLLAEEMDGRKGEDRIEFSIVYGGPNTNFLKQFTLGDLRLDERLKGYMRRHLCGSDDEFGFIPNDNPVEDLVVDEDAMSMMAMSAIQSQTTHAQFRLGPEVKGWHVCRQSMTTQILYGITQAWGPSWSAVPMHVGAVYKDPKSETKVEAWWVHDFAQKRLYIAKLSMKRHEGLEIPLRLVLRAAVHEAMWFNLREIVAWDPNPRLVAQAERLVKDLGQDMTATLENRSEMVPCFRWHGGEDKDVVWRDGEYWTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRN0</accession>
    <name>A0A2T4BRN0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1449314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRN0"/>
    <dbReference type="STRING" id="983965.A0A2T4BRN0"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015481144" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="395"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1018" mass="111195" checksum="19610A6F3C32B8D8" modified="2018-07-18" version="1">MMNPISLLSAFALLLAGIDALSIGIYGGRPRDLILDDAKGPLQDIVTWDEHSLFVHGERVVIFSGEVHPFRLPVPSLYLDVFHKIKALGFNTVSFYVDWALLEGKPGRFHADGIFSLQPFFEAATKAGIYLLARPGPYINAEVSGGGFPGWLQRVKGTLRTDAPDYLHATDNYATHIASIIAKAQITNGGPVILYQPENEYSGASEGVLFPNKPYMQYVIDQARNAGIVVPLINNDAFPGGTGAPGTGLGSVDIYGHDGYPLGFDCAHPNAWPDNGLPTTWRQDHLNISPNTPFSLVEFQGGAFDPFGGWGFEQCSALVNHEFERVFYKNNMAAGVTIFNIYMTFGGTNWGNLGHPGGYTSYDYGASIREDRRVDREKYSELKLQGQFLRVSPGYITATPGNATQGVYSDNQNVVITPLLAKESGNFFVVRHANYSSTESASYTVKLPTSAGELTIPQLGGSLTLGRRDSKFHVTDYPVGQFTLLYSTAEIFTWNKFADKTVLILYGGAHELHEIAVKNPFGNSKPTKAKKIEGSNVTIHTAKDLTIVLQWTASSTRQVIQLGDLVIYMVDRNTAYNYWVPTLPGSGKQSAYGSSLMNPDGVIINGGYLVRSAAIRGSTLSLQADFNVTTPLEIIGIPKGVLELVVNGNHVDYSVSELGDWIAHPAIEFPHIQVPDLSKLKWYKIDSLPEIRSNYDDSRWPLANHRSSNNTFAPLKTPVSLYGSDYGFNTGTLLFRGRFTAHTTRQQLFLSTQGGSAFASSVWLNDRFVGSFTGFDAASAANSSYTLNGLVRGRRYILTVVVDSTGLDENWTTGDDAMKAPRGILDYALVSSSGSNVSISWKLTGNLGGEDYRDTFRGPLNEGGLFFERQGFHLPSPPLSAFAHSPSSSPLDGLSRAGIAFYAAKLPLDLPAQRYDIPLSFVFDNVTDAAPYRALLYVNGFQYGKYVSNIGPQTEFPVPEGILDYNGDNWVGVALWALESRGARVPGLALQSKAPILTGRERVEVVRGPHYKKRPGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS19</accession>
    <name>A0A2T4BS19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1342556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS19"/>
    <dbReference type="STRING" id="983965.A0A2T4BS19"/>
    <dbReference type="OrthoDB" id="4885943at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="198"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="764" mass="86538" checksum="B4BAF7F5AFCF41B8" modified="2018-07-18" version="1">MPIDYEIVEPRVYDLLEGQQPDFDNDELEEAQALAKTELIRNKSIPFKYWLEQPCPSGRNTEGQAAPCVTFRRGLHEFMMETNSDYAARKELMLYMGFVATGGSSASQCLRIGHLSAGNVPARAWAVEVFVKTVPSGNTASDEAFQKAANWFRECHDTHTHCSVGEAPEMPDRVLDIAAESTASGVKLIHTNGSKARYACLSHRWGTDTSKALKQNISSLCDEVPWDYLSLTYQDSITFMRKFSKWHQQEYGEEIRYIWIDSLCIIQDSKSDWKKHSLKMSDIYSNSSLTLVESHGLHTEKRLFQDSTSRNPPWHVSVRDAQGNDHELHYRHTICHPTFMVADDNVPVWKRAWVFQERLLSHRILVFGADELSWQCTGHHKCECGLDEIHTQSHRLLREWGHGIRIPLHSTNSRREMHEALGDDPSHKQLRRAWRLVVEAYSRLDYTYRSDTLFAIAGLAKDFNARMGGKKNYFAGIWYDELKDGEAAECLELQAETALDLLWRLAYHKDGQRENLPAPAVPISWSWASPECPIVYPFANDQVLNQYSLVSSIGGTANVLKLPDDDEKPRDRVKDDMYTAVTPSPIALTGPLWKTKLASAPFSFTIENTEYSEYTYFLGAMSVGVFKESAVGSTIQQRRHLLTPPRDGAESAEAAMNKMPPMVFYPDSMSKVTSESLYCLPMASFKRLPIKSTVKEKVVLAALVLEPVGHKADAEGYDPYLSHRDASELVFRRVGLAYTADGGWTDEHDEMLAKLPTHVVNIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS92</accession>
    <name>A0A2T4BS92_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1100704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS92"/>
    <dbReference type="STRING" id="983965.A0A2T4BS92"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="544" mass="60588" checksum="A778A5B95E262645" modified="2018-07-18" version="1">MQRQLAQVDESQVPGTVLLVDVDHNTQIRHASSQDIILVPTPSSDVNDPLNWLPWRKRQHLICLIAYTLYNGMALSVVYSLLVPLSTALHVSVGDLNEGTGYMFLLCGWGLLFWQPFALQYGKRLTYLLSMLGIVAVSVWSPFAKGQGQWIARNIVAGFVAAPIEALPETSITDIYFTHERGTYMGWYAWILATSNYFAPVICGFINDSMGYKWPFYFMAIFGGACFVLLFFFLEETNYDRPLVGVLQAVEARESASEKTASSSSAGAAAVNESHGAAALPANDSNSGMLQGKEKSYRQKLSLLDKPRPFQMHRRAWQILRLIAWPVVFYSGFSYGTYLIWFNILNATSSIVLGGAPYNFEPSIVGLSYLACVVGVVLGSAYSGIVSDWFIIRLARRNRGIFEPEQRLWLFALTTILVPACQILWGVGAAHHVHWFGLIVAMCVLAACNTAGITLSITYLVDSYREISADGLASCIIIRNTMSFAINYGITPWLDGLGLQNCFISVAFVALAICSTFLPVIWFGKRLRNLKRESYWREAKLRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSA0</accession>
    <name>A0A2T4BSA0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_22769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSA0"/>
    <dbReference type="STRING" id="983965.A0A2T4BSA0"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="301" mass="32058" checksum="F63E77466D4B5CCF" modified="2018-07-18" version="1">MPRLLSSRDTIRNELIVVFGEFCGTFMFLLMAFIGTQAAIENNSPGNPDAPLFPFSLMYIAASFGTAVAVNVWVFYRITGGMFNPAVTLGLVLVGAVSPLRGLLIFPTQLVAAIAAAAVTDALLPGPLLVANKLSPGTSISRGLFIEMFLTAQLVITVYFLAVEKHRATFLAPLGIGLAVFIAHICGTNYTGTSINPARSFGPAVVTDFTGYQWIYWLGPFLGSFLAFVVYTILKWMEYHTANPGQDDDTAAKKTPAGLAVATNDRQYRSGSEGGKYRSPSGPRDSGIAHTSSGPQGFAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTD1</accession>
    <name>A0A2T4BTD1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1341634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTD1"/>
    <dbReference type="STRING" id="983965.A0A2T4BTD1"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="423" mass="46942" checksum="6AAFF65604C22CBC" modified="2018-07-18" version="1">MDLAVTLIKAVMRAFYSTRDILVVDALILHEALRDDDLAYLMAINTKDLHKICGKLREDRFLTVHTRSELRPGNPRPSNRTWYYINYRHTIDAIKWRVYNIDKEVQGTTVPVNEKKEYFCSFCKAEWTAMEVLDSVGPEGFLCHRCRRPLSFEADRNAGGHEQSTRLNDQFKFISELLPKIDAAHIPECDFDRALSKARPVVRDATHQRAATIPVDDGSSRPMAVRGLANVGPQSIAVNISTSDGPSEAEKEAERLRKEKIAQQNALPSWMSNSTITGESFSATAEAGALGLSKEAAGGESKSNLVENSATTQIDDIFEKIKAEQAALLAREADAEDEEEDYGSEEEEDDEFEDVMATGNNSGMGTPGIKVEASEAPSGDASRVEDSSEDRANKRVKVETEAVKAETGIDEEEDEDELEFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTD4</accession>
    <name>A0A2T4BTD4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1341719</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BTD4"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="54"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="1081"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="12">
        <location>
            <begin position="1275"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="12">
        <location>
            <begin position="1564"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="765"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB72569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1731" mass="191697" checksum="9EF9EAC0BB6E5BDA" modified="2018-07-18" version="1">MLSPLRSRLVKATFLGTCRQVRLASSAKYPQAVSPLAFDLHSPTNPSKDEKTAPIIFLHGLFGSKKNNRGISKALARDLKTHVYTVDLRNHGESPHDPRHDYVAMTEDLLAFIDQHGLKEPTLIGHSMGAKTAMSAALRSPETVAKVVAVDNAPVDVTLSRTFASYVRGMKKIEEAKVTRQSEADAILRDYEESLPIRQFLLGNLYRSPEDGIQRFRVPLDILGRSLDHLGDFPYKNPEEARYTKPALFVRGTQSKYVPDDVLPIIGQFFPRFRLVDIDAGHWLISEQPEAFRQERSEYHLDHYRAASTELYTVPRTNQDPVPREARHSFGRSASLSLISTRSPRSPSSPNPPPPSIVGMLPLVQTHPRVVPVPVGFESFGTPAARPEADRRAIASPYHLSASHLYGGPVPSAAAGQCSRDHDHHLRRKTPRGTIDAGYDGSPTQLSPGPPPLKQLILPTPSGIYPYVPPNNLPFNAKSRLPNADAISLGQAPAVSPWSLSYGGHNFVLSSGSSMLPPPGPSWQPYGYPMFSQVPGMYQPLMRAAEYNVRAFCPPPASAPDAAAFNQFGWQLGASQQTLGYFDPSQYPEPRPMLLPGSIPHHTSDVQLPYRPVPDFKAGHPDVPFPSQPLVQGGYLSQSTLVEDAPAGEQYAVQASFTEKVYSKAQAHYVELLAYLQTARRLDQMSNGGTSSSSHVEAITNLAATLYCLNRQEEAEQYWLRAIKLRPDHLEATEQLVGLLYKKRSREAIDIICFVQQALSLSRRNSTQTSYPASSDDRLLGQQPSKSTAPLNYHYEAASTTTSHSSRRSDFGSSGYALPNSENGRILALVHAKGTILYGLKDVEKASEAFEEAVLISVGERIRSVQDLVNRIHSVLAPAGSFSAGNERRPVSRRPLLLPPEKARQTAHLVFAADGGGSELPGLAFVPEGAARRVAVQTTSNALLSLAKIFQDAMSGGNTVPNLLRQPTGIGDILALYYLSLSLQESPSTANNIGILLAGVQQAAPSNVSTPGMVPSRPSLPGVVPGSGLALALAYYNYGLRLDPRHVHLHTNLGSLLKDVGQLDLAIQMYERAVSCDKTFDIALTNLANAVKDKGRIKDAIAYYRRAVDSNPDFAEAVCGLLTALNSVCDWRGRGGALLESGRYDRWHVDDAGTLVDVRTAMRGSGLTQRVIGIISQQLDDASHWGRGLLQQPTIQGLVQQLQEFCHNPGFDLENAIRAWACDAWEGSRLVRLVERATRVILWKWYHDRHVAQREATPSHYLRPQLPSSLTIPSAPTVLPFHTFTYPLCAKDIRSISQRNAMRISCSTLRAPWLPPTVYPPPPPPNPYLNVGYVSSDFNNHPLAHLMQSVFGFHNPQRARAFCYATTPSDKSIHRQQIEREAPVFRDVSSWPAEKLIEQIVRDEIHILVNLNGYTRGARNEIFAARPAPIQMSFMGFAGTLGAEWCDYLLADTTAVPPSTLRPWRNNTTIEDVFQDETEGDERQWMYSENIIFCRDTFFCCDHAQSCDANERDMTWEDEERRRWKMRKELFPTIADDAIILANFNQLYKAKTNLRQTAEAWAGAEVASRLVFTDVAPKNQHINRARVCDLFLDTAECNAHTTAADVLWSSTPLLTLPRYSYKMCSRMAASILRGALPKSAEGQQAALELIADGETEYEDQATELAGGLTYVMTDEGYGRGTGRLAEIRKLLWDSKWKCGLFDTRRWVNDLERAYEEAWRRWVAGKGGDIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTI1</accession>
    <name>A0A2T4BTI1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1433427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTI1"/>
    <dbReference type="STRING" id="983965.A0A2T4BTI1"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="109" mass="12035" checksum="F55BE9F7A0A9A584" modified="2018-07-18" version="1">MATIFKLIFYVPQSHIEVCKAAIFAAGAGRYPNSSYTECCWTALGTGQFRPVSGANPHIGQVDKLETVPEVRVEAPCVGQEVAKKAVEALKKAHPYEEPAYEVYRLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTW4</accession>
    <name>A0A2T4BTW4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1081569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTW4"/>
    <dbReference type="STRING" id="983965.A0A2T4BTW4"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="183" mass="20634" checksum="F11A9B88F7A8FEF8" modified="2018-07-18" version="1">MAGLFRKVYDWLLRTFWALEMEVTMVGLQNAGKTSLLRVLAGGEFTLDSIPTVGFNMKRVQRGHVTLKCWDIGGQPRFRTMWERYCRGVNAIVFIVDIADVELIPQAKEELHSLMAHPSLAGIPLLVLGNKSDLPEKLSVDELIDELDLKSIQNREVCCYGISAKQETNLDAVVQFLVKWAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVA3</accession>
    <name>A0A2T4BVA3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1340285</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="PTB73244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVA3"/>
    <dbReference type="STRING" id="983965.A0A2T4BVA3"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitotic spindle pole body"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB73244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="144" mass="15193" checksum="62B644A931E321B9" modified="2018-07-18" version="1">MSYPTRSFSSHMRAPSSASAPQSPALVARIEEKKAELENLKELRDLSANVASQMEALEQKLSTLSEGTEVIAAVVGNWHNVLRAINMASSKLAKTAAGGAPEEAPTSTAPLPQTLVRIPTEHAPTLQAQAEAAEAATEESMSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVU5</accession>
    <name>A0A2T4BVU5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_29655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVU5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVU5"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="107"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="107"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="304" mass="33531" checksum="81BD19449AE98508" modified="2018-07-18" version="1" fragment="single">PAVAVPGPVPGVPQRVVDNDSFLRVRDSAVGRLTTILELLRSFTNDYIRQTNLLLGEGTAEGPQGDLLNTFDAAAQLIGNVMPMPDMTPMVEEKKERKKRTHDPNAPKRPLTPYFLYMQHARSIIANDLGADAPKGAVQEEGQRRWAHMTPQEKQGWNNAYQYNLRLYNARVHSYKNGNPLAKNMNDEEALKYAEDFHIPMPEIKDAAAPAEAPVNDQDAIAEQLQQVAAATSEGDEIEAPAAKTPKKPASSRKRKTATPAAEQETPKAAAPVSPDKKRRRTSAKVAEPEKEEPKKSGRKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVZ3</accession>
    <name>A0A2T4BVZ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_132314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVZ3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="13705" checksum="53A21D9ECE443D4E" modified="2018-07-18" version="1">MIPLSASFSLVRASQTKAEALDSCRLTLPLPPPLAVPRLHELLSVHGDIVGQRRRPRYGAQRAISFPKARCFWRLASYSISPKVPACPSPFTLSPCGYVEVLHCLTAITYSVAYPAAILTADAHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW86</accession>
    <name>A0A2T4BW86_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1065658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW86"/>
    <dbReference type="STRING" id="983965.A0A2T4BW86"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="7">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="449" mass="51531" checksum="0ED84880D76988F0" modified="2018-07-18" version="1" fragment="single">MASLYQPRPVLPSQVIPHAPEYVDARRNVHGARQPLREAAGNAQAHNFNSNIPCYQPVVSSLPPTVPTHIVPSQSIEALYNRLQTPRHQPRQVRKSRHDINPLYFWPAFKQYRNRQAHKDTQKDKGGVWRRPELEDAFVDSVLLMPHMGRRKFSMGGKLHGRNMLISEYIFVICVALLGDKEIFRIDNSNDSIEQMGRKQVSSHMQVVKKFFEDLRCFHFLFPSEEKKEPGSTNSDDYYDEEGQESFKSNPILTALAEGRVPEVRPNYEYFSQLLSLQGLITVRPKTCEIYVSSAEIKIRDDVAYDANNTPLDQASFPHLNKYTNCDDFPDALGKDVLLHEYTRALDRATSACLKTVTRRWQKDAPAMYETLDLPTRDEECLLLEMCSTLELHEHAKFPSGSELTGFVEVAITQPELQHHHWKCVTRLTRPDELYGDDSKRGVYTNESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWF4</accession>
    <name>A0A2T4BWF4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1339623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWF4"/>
    <dbReference type="STRING" id="983965.A0A2T4BWF4"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9892" checksum="F6D6BB4EE7C92274" modified="2018-07-18" version="1">MSSASKISLAATSLFTAGVIVFVHFQQKADQAAMHAGVVRDMEQQRVKRERQLDFDMQRALEEEYKREQNVHSSLEPLDKASNTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWF6</accession>
    <name>A0A2T4BWF6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_135952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWF6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="20324" checksum="E65D6B25712B3848" modified="2018-07-18" version="1">MRAAVDNRVVRDLCMTSMHAASWSDLDVHRRRIIGDLYDSHRSFISETQLVLHLGMVSIRWTTTAMASAEIFTSLDGSSLHVKILKQVRTPLSPTPSSVAHTKSSARIRCPRGSSHRTGFTVVLLCRTKDRNGATSADAPDLGTTHFPSRTSAGSLCALPGELLQHMRCVSCLVANRKGRGEAVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWZ0</accession>
    <name>A0A2T4BWZ0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1464604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWZ0"/>
    <dbReference type="STRING" id="983965.A0A2T4BWZ0"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="549"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="942" mass="106521" checksum="296F35966247D547" modified="2018-07-18" version="1">MPKLLRMSYPWGIGGLDKSRFEAYAKLLRLKTGGQVEEASNFSQMPDEELESDTLDDADSVNADAFSMFDEKKLKRALLDRLSELVANEKGGYHVSSSLMIEWPDRVDILVARNNGFREADATLRMLDTIASSLRDISRLGSSDPVATSVKQDLWTSLIHSYRPRLNSYMVQAKLAMKAINRSAGDRVEALTLADRPPSLLSRLEEIRSLIDVVTRLPTQEGIKKLIQSAHDIYILYNEQDFDEATGNHTDMRSLRDALGYLGRLQTCFDTFVRSAERLSSFQNLRILPVIDTATGQAKTITTVRNNAWSLAQTFSSLGLTLDDKTVASIIGTGKKKGAWTKNKLLQKFDKLRTSVSEVHAEVRVVLATTKHDCTGAAIFKYVGCSKRSCFLCSRAIQNFGSYTTRGCHGKVYDHWTVPEFPWLAQEEGLKLVQALKNVERAMKEFIRNGRTSGLIHACESTIGGSSVATRRLQFVEDPRTISLISEHLRSQRQGMRSHGRKGEEFASPSQSLPTAAHHRADAGTHLLRQTQDGSLGTAQDLEQIQGRCGICENETDRRCQYCNLDWFCSQQCQEQMGFRHLTKCSARSITTADIIFQDAISDQLPQDPETLDHFGFTRCRDMREQSHLLGLYQGLLHYRVRATQLNEWRERDILASKIIETFCRKPEKYRGSYFPWFLRNQHVLDSSSPPLDLYGKDNPFERAIIAARPYLDPGDRAKHVEQLEPPAKRLCFLFYAMALDGSHPSPYWDGLDLWYNFGFTTSAEGHLGHFYSRLVGGNKSSRDYDQSLGTDSGDYPDLPTCSFNEFWMAYEAGTLPKLFHRYGLGHALGHDDGLLEFLSFPPSRDALRPSIWRLKHLLALDPNTPLGSYPGIEAAAQEYGFVSQLDAGTRLDLRYFYERLFKKVNPLRVHEAKSRGELLEFAESSLGVIDDRVRHVLRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXI6</accession>
    <name>A0A2T4BXI6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXI6"/>
    <dbReference type="OrthoDB" id="4899822at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="292" mass="31598" checksum="0DE4146DE0AAE762" modified="2018-07-18" version="1">MSAVSSCSDSRESFGVPKDAHSFRSSYHRLARKCRRTASPSVPTTTALVSAALTSAAPVVKFEARRTRVLFVPDIPKTSHSTSTLSHSASQASSSVAVEAQDVPPPSPSPEPAAVRTRPRISIRTTSIDDGLAHQSTTARKTVWKSSSKESLASPTPSPATTVSSTSPWLEVPISPHSPRRNRFGRGHSSDYSLRNASQDSHTSQSSFRTTGSTESKKSRDLLQAIGSMVDDHVRQLRGSILSPVGKVSRLPRDHCRETLVCLQEDIHSLLQRQATNQTHSFPLSRALRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXQ3</accession>
    <name>A0A2T4BXQ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1440936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXQ3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXQ3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1156" mass="127611" checksum="23EB9F5AFF0D88E3" modified="2018-07-18" version="1">MSRPPPNLIVHRKAVQQTPATEIRNLLTIQAALLRGDKHVTLHNASRVTDLDAQRLRVPYHPRHRAHDRPYECLFGFRASSSSSSSGGTTQPKRVEDFIEMLNWDGFRLEWVKVLGEGGFGMATLWNAIFEDGSSVKAVIKIPVRANTNFDREMEWHLRYAGASHVTQALDLQAMADNVRRKMNRGYMINRGARFIPSDLDVLVLEYADRGSMFDLMNRASHFNIVFSNKVLWEIWECLVKGAVSVALQPDAIRRWGRDGLDKVLESLDDPDNIDELRRICTLIDSHDVHFDIEEQNVLIAEDEHHGHHPIFKLHDFGEFSHKMRVNWAFWPESEYWRLRRVPKSNRVPPETIAREWDTFDVANPGPLQRFVGDTFGPDKNVSAGRYGTWTNLFLIGQIMEAVITKLWVSHPMSTMRFRPYDFRSDGQTYGWRICRPQFGWIEFELRSLILQCQYENPGDRPPLAYLLQKIAERKQRGFPDEPDRVTRQFWDLFWAMQRPSQYPGANNNNNNNNNNNNNNNNNNNTQNVQPLQPHAPPVPPPAPPPVVLPPQGFITNPYATTSYAATGNPLIAHVAGLRLKSHRSPLISSSGAGPSVQPPQQAPYPHIGGQPSATFSSMRMSDLASTAPLLGRPAAQSSSSEEHPTRPSAPMFGRPAAEDTSGEEFPMRPGAATAQLVRPPAAETSSIPDFFMRPTAEGMPLRRPLPTLGPSGEEFPIRPGAMMVQLGRAPDAEGSSGEEFPIRPGATVAQARPPAAEGSSGEEFPMRPTARVALARPPTGQDSSSEEFPMRATAVQLGRPPVIEGSSSEEFPMRATATIAQAVPPSSQSSSGEEFPMRPTATVAQVRPPAGESSSGEEFPMRPGATTLQLGTPLIHERSSSEEFPIWATGLHLQQSPIAESSSSSEIPMRPGATVAATKKRSAEEAADADAEESESTTSSQRKKQRRVRFDAASASSTVTMGMQPVHLVETATDQSPGSLTRQWPVVANTPTPDPASAATGDASGADRHAEQMRSLHNQYDPGSTLSLAVPETDSRGRIKAGSKKDSKRKKLVKFFRLDRLRNRFRGTPSPGAAGAVQVESTPELGRTSKMDVDDGEQQRGEAVDEDAVMGEASAARERGGVARNERVWWGDEPRGGGNAGNATTGDRIWWWVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYS5</accession>
    <name>A0A2T4BYS5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1381370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYS5"/>
    <dbReference type="STRING" id="983965.A0A2T4BYS5"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="90"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="216"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB74458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="478" mass="54940" checksum="09979CAF0CCAEC15" modified="2018-07-18" version="1">MSKRQASEALDELQDVATPASKRSRMGDFDSPLANSSHDDAQSLDQDADARKQGTQDARSEDEDADDDDQDLDNEPMAAPVRQSGPADGYDDLYLDTIDRNVLDFDFEKLCSVSLSNINVYACLVCGKYYQGRGVKSHAYFHSLDEDHHVFINLETQKVYVLPEGYEVKSKSLDDIKYVSDPRYTKEEVIQLDRRRPSDAVISWTLDGKPYTPGFVGMNNIKDNDYLNVVVQALSHVSPLRNYFLLEDFSNKSELVKRCSILFRKIWNPRAFKAHVSPHELLQEVALQSNKRFTLTRQSDPVEFLSWNIIPQVPLSTILSKYDGKRAQEHHAQRKRYRLLHPLPPFLMLHVKRFSQNKFVAERNPTIVTFDARNLDVSPYVEPNPSEWPVGEPIWYDLVANVVHEAVRKRDDVADSGEEKKTWKVQLKNKATDEWVVCQDLFVDKVQSELLYLGETYLQIWERRRVPGKKADKGKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYY2</accession>
    <name>A0A2T4BYY2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_97018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYY2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="134" mass="14628" checksum="343367E98079A53A" modified="2018-07-18" version="1">MLSRLVGAITSTAWSSAGLTPSLSSPAMPCLGMCAITTSMSILCVDAICPSSSRSFFLKGKKAEYPSPPDLPVCLPCGVAKRYVNAPMPRSVRMARWCFTSPGHTHTSPRRQFIIPAASYLMHTDRYFTHLPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ06</accession>
    <name>A0A2T4BZ06_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_97579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ06"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="92" mass="10340" checksum="1966701C2D9C1405" modified="2018-07-18" version="1">MTSDACWKGHYQKRQCAAPNFTQGGLIWGLFFWFPFMVVGILFVVVILLITLNTLFCSTCILNSECGNDMQGARLGVYFGGTIQGQLHLHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ31</accession>
    <name>A0A2T4BZ31_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1029998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ31"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ31"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="281" mass="29155" checksum="6F73AEF6511A6329" modified="2018-07-18" version="1">MSLPTALPPRPSRRLDGRVAIVTGAGSLGDGLGNGRAIALLLAGDGATVLCADRDLPSAKRTVEMIVREGGSAASLCADVSSEADCEKLARTAEGIFGRLDILVNNVGVMGARGTAVDASPEEWAEGLATNVTAMVLMAKHAIPLMLKNQPGDGGIRGSIVNMGSIAGLQGGTPHLFYPTSKGAVVNMTRAMAYNHGRDGIRVNCVCPAFAGFLYTPMVAGSGMSDEMRDARRRQGLLNTEGNAWDCAAAVRFLASDEARWITGTTITVDAGATCSYVMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZI7</accession>
    <name>A0A2T4BZI7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_56718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZI7"/>
    <dbReference type="STRING" id="983965.A0A2T4BZI7"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015548771" description="Phosphoglycerate mutase family protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18487" checksum="DA1EA1A9783EBCDF" modified="2018-07-18" version="1">MKAAFLLLWGAALATAQTVYFIRHGEKPDDDDDPNLSAQGVQRAQCLRNVFGASSQYDIQYIIAEKPKDGKRIRALNTVTPLANDLGLTVDTSCGKTKSDCVADLVDDYKGSGNILICWEHSELTNIAKSLGAKNAPDYPDDSFNLIWTDPLPYDTITSITSENCPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZT6</accession>
    <name>A0A2T4BZT6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1423743</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BZT6"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="413"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="732"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB74766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2326" mass="253223" checksum="2575D44DE69D1910" modified="2018-07-18" version="1">MAGLFQSFRSSSMPKRLLRYALSRLELLDSDALDMDNLDLALGRNTVFEFRDVGVQLDKLEKLLKLPKTFALQKAKVLLLRVTIPMDFYTSPISIEVDGVDVKLKVVVPDAKAKSSHPTTTTSDDDDTAAAVPNTVDLAQSFLETQPSSERRKLEAALVAETQDLGASGSMSDDSSEDEPIVGTGQPLSLPGFLAGFLQGIVDRMQIKIQGVAFQLDMDIPVDISASATEPVSFQIALEGIDIEGVTTKSEGSRASAVAAPKEGKRQISLDNVRAYLISEANVFSTLTRSSSMTSPSAASSPVHTRNPPSRQATSLSLESLQEPAFEPTFAPSFVPAALSSHSGYLDQTQELPRESGHSQQMSTSQTSSSNPSIQSLHASFLGRATDAHDLDQPSYPLADSEEALGIPYEFEDDGALDDECPATPRASQSREFGSPQESAFHSPEDPALNASTTLRNDFDDRLSLSQGYYEEQGMASSSILQHPEGLEAFGVYGLQSSPDSGSEGRVEPDAAEDLAQSHLYTHEEAESMYMSAFSKAGGQSSDDISELESSRHTLHPADVEEHASYPAGVEEQATYPADSEEHAPYIADSEEHARHVADAGEHTFHPAGVEERTPSPTDMDERTFSSTDAEERALLPADVEEHTLHSTVAEESTLSPADMEQHTLSPEDVDTHTLPPANVDTHTLPPSDEDEHTLSSADLNEHTLSPADVDEHTLPQADVDRQATQSPIEETTELMRTPQAVQGQFSQSSAPFSMPGGWDDDLSETDRVASPEKGHSPRNSISEPQPQLVPEGEAASTAGLAVEQQNPSSRIEGGLRDAEEEPPQMEDTATPKGPTRVVKEILHLQSVSVYIPTAHPHIELEEDTSESVAELARAMSNSAYPQAPGAFSVHAPASGSVFEHRPHLQQTQSVDNVLEVDLSPVSIRFDASLAFVLAMIAGKLLDAVKSKHPVAKPHQGADAAQQQEKTPEVKVTVQEVTVDFLNRLAGVADTPRRHLDPSAFMFDQEVLLNATVRNLSVSVAPVKIPSGHAAGGTAGETQDAIQTRIDLETFRFGYSNGDIISFDKAAQMSTSVRDTFLSNGHDIAIKMAQAKESIRTEIETLPLAVHVDLQRLDETFSWFGGLSSFLNMSASMTSSPSPTPKSPLKPAQRTKGVRFETPINPDDKSAVSENKINMRIGGSYIELVGRECSFVAESNAIKFINRERGAGVSCSRMRVSGPYLKNSMAKPAINTEVGGMRLEFVTTPNDSDLERLLGLITPSKAKFDHGSDEIMVDTLIRQRRKGSVLRVGVETLNVRVKNLAQLEVLPTLAEELAKLSTVAKYLPEDDRPGIMTLAKVHEVGASVELGGTFGQLSGELKELEAAHISIPSLVAVAISGISVRRNKTEELISSSVLYAPAEIANRGPVIMARMIGDDIEPILKLNLQDISIEYRVPTIMDILGLANDATPQDFEESLAASVASLGDQAHAALARQQPISPTHAPSKQSKPLTLDVSFRDCLVGLNPLNQKSKMVLVFTDARLAVVLPKDEVTKVTLDVHKASILLTDDASQTTLDYRPSSSTRRRASSSASPQAVSLSAQGFVDICYMSSAKVTVVVAPGIDGEKQVEVEVRDDLLVLETCADSTQTLISLANALSPPTPPSKENKYRTKVMPVQDLLASISAEAFGRPEGEYDFDQDFAGAQEMAQSQSEADFGVDNNFPIESQFYGDEAEGEELFDAMKLSATSQDTRMQDTQEGVLITGLDRSRSYISEGSDDLAFKEDFFNETAPDEHGAKIWNSIKNSYDKAPANLVKRSPLKVSVRDVHVIWNLFDGYDWTHTRDTISKAVQDVETKVYERQARLGGRQVFEEEIEDEETIGDFLFNSIYIGIPASRDPQELSRAINEGLADNATETESIATTAVTTSTNRTVRRGYPKSRRLKLQRSKHHKITFELQGVNVDMVAFPPGTGETQSSVDIRVQNLDIFDHVPTSTWKKFVTYDRDQGEREMGTSMVHLELLTVKPLPELGASEIVLRATVLPLRLHVDQDALDFITRFFEFKDDSVPVHSSPSDVPFLQRAEVHDIPVKLDFKPKRVDYAGLRSGHTTEFMNFITLEESRMVLRHTIIYGVSGFDRLGKTLNDIWTPDVRNNQLPGVVAGLAPVRSLVNIGSGFKDLIEIPLKEYQKDGRIIRSISKGAAAFARTTGTELVKFGAKLAVGTQYALQGAEDMLTTGIKPDDGWDDDDPDAEDKKQISIYADHPTGVIQGIRGGYRSLARDVNLARDAIIAVPGEVMESQTATGAARAVLRRAPTIIFRPAVGVSKAIGQTLMGATNSIDPHNQRRIDEKYKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0T8</accession>
    <name>A0A2T4C0T8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1458518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0T8"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="191" mass="21208" checksum="5D38A190F64BDD40" modified="2018-07-18" version="1">MLLCSYSTFNVRIIGNASISQNFSKTPPLAQVNQSLRFALGVLLWPEHHAKPHIQEHITLFHFDAMADSSQAHYTVYRIECQFSKSSRHSAIYVAMGPNGAGQLLHVRCAVGRPNMMFEKQYFVSNGPESLATFVYKIPVGNVRVEDVEKLTDVCYTIPPPPTQYIGEVCQCGAWVNEACVAFRVAGLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Z5</accession>
    <name>A0A2T4C0Z5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Z5"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="10922" checksum="C2214CD32667F7D7" modified="2018-07-18" version="1">MSWRASETLMDTIRHYAKFPATGQLSTAHARHSPSSSATSSSSTATPSSSSSRPRSLLAIRSRLKDPARREVTERRQVGDAEAVVNAPPSSSFLHGDDKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C100</accession>
    <name>A0A2T4C100_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endoglucanase EG-II</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1271740</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Endoglucanase (EG) that cleaves the internal beta-1,4-glucosidic bonds in cellulose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with EGs, which cut internal glycosidic linkages to reduce the polymerization degree of the substrate and creates new chain ends for exocellobiohydrolases (CBHs). The CBH release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C100"/>
    <dbReference type="STRING" id="983965.A0A2T4C100"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000124">
        <property type="entry name" value="Exported cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015519436" description="Endoglucanase EG-II" evidence="18">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="59"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB75247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="440" mass="46972" checksum="2E635CD23CDF9E27" modified="2018-07-18" version="1">MRATSLLAAALALAGDALAGKIKYLGVAIPGIDFGCDIDGSCPTDTSSVPLLSYKGGDGAGQMKHFAEDDGLNVFRISATWQFVLNNTVDGKLDELNWGSYNKVINACLETGAYCMIDMHNFARYNGGIIGQGGVSDDIFVDLWVQIAKYYEDNDKIIFGLMNEPHDLDIELWAQTCQKVVTAIRKAGATSQMILLPGTNFASVETYVSTGSADALGKITNPDGSTDLLYFDVHKYLDINNSGSHAECTTNNVDAFNDFADWLRQNKRQAIISETGASMESSCMTAFCAQNKAISENSDVYIGFVGWGAGSFDTSYILTLTPLGKPGNYTDNKLMNECILDQFTLDEKYRPTPTSISTTADETATATATATTDGDAPSTTKPIFREETASPTPNAVTNPSPDTSDSSDDDKDSAASSSAQGLTGTVLFAVAALGYMLVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C163</accession>
    <name>A0A2T4C163_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1336180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C163"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046312">
        <property type="entry name" value="DUF6454"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20055">
        <property type="entry name" value="DUF6454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="373" mass="41410" checksum="BEA1DBCF7013A8CD" modified="2018-07-18" version="1">MLDSYSLHRITSAGPKQPLASMSKVNISVLTISAVFIFVLVFIYPFPHTPFAPSPLPLSHAASDGETIIKLFQTLGRTTVWKSIANISFQGDTFEPEGLVRLGPDRYVISCGEYTEHTRKYPHPINGTDRTPGKGFAHLMVYNGKGERIADATITREGDEEYHNGGIDYDGRWIWGTLAQYRPNSTANVYRADPYSLKPQTVLRYHDHLGAIVHDTTKNTITALNWGGRNASIWALGNKVRADCCPQQQEPGSTIRNPSYFVDYQDCKWLGRREFYHGASVMLCSGVATLDDGYSLGGIALVDAESMQPLAEVPITLKSLRGVRMTQNPVDVSVEDGKLRLYWLPDQRNSTLYVYEAQPESPFEYGGGPIGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C291</accession>
    <name>A0A2T4C291_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C291"/>
    <dbReference type="OrthoDB" id="4893087at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="230" mass="25330" checksum="48FA2E902101BF6C" modified="2018-07-18" version="1">MPYTTLPYPVSRSPSPSRLPSQRAPCSIPPYPISHTPSTLISHSDISELALPSPLLPVDPRPLQSIQLIGLRHSAYASYIPPSGPSSPLFYPVDPPNGPPSPTHDYFGDKDYPPRSLLLTDSLIETLHTALSIDIVDELGIVVILPPTFSRTPQWETTPYSPELSPKGEYIELLTYGSNAGVNPKFLSDAAFMIEIRDEAKLVENIGEGLTFRSLRHMLEAYYELLYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Q6</accession>
    <name>A0A2T4C2Q6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1335077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Q6"/>
    <dbReference type="STRING" id="983965.A0A2T4C2Q6"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123372" checksum="BAA7EF12AAF7A444" modified="2018-07-18" version="1">MPTIEELDSTVRAFYEGRGEQQKAAQAALNQFKEDPDAWLMVDKILSDAQYPQTKYLGLQVLDNVIMTRWKVLPREQCQGIRNFIVQFIIQCSNSEETLRAQKTLLNKLNLVLVSILKQEWPHNWPTFINEIISSCHSSLSICENNMIILRLLSEEVFDYSAEQMTSTKTRNLKQTMCAEFSQIFQLCQEVLNSANQPSLIKATLETLLRFCNWIPLGYIFETPLIDTLRTRFLSVPEFRNVTLQCLTEIGGLQTGGPGQPNSYDEQLVKMFTEVLTTIADIIPVSLDLKATYPSSNSRDQEFVQNLALFLCNFFGMHLNLIENLPNRDYLLHGHYYLVRISQIDDREVFKICLDYWLKLVQELYEEMQQLPITDLNPLLAVGGGMSGSGAPNPTLLMNYPLRKHKYNEILSNLRVVMIEKMVRPEEVLIVENDEGEIVREFVKEGDTVQLYKTIRECLVYLTHLDVVDTENIMTEKLARQVDGSEWSWHNCNVLCWAIGSISLAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHESHEVGVQDMACDTFIKIARQCRRHFVALQPSESEPFIEEIVRNMGKITCDLTPQQVHTFYEACGYMVAAQGNKNQQERLLAELMNIPNAAWDEIIKQANINPSILQDAETIKVIGNIMKTNVSACSSTGPYFYPQIGRIYHDMLQMYRATSSLISEAVARDGDLATKMPKVRGLRTIKKEILKLIETYVEKAEDLQAVRTQMVPPLLDSVLVDYNRNVPGARDAEVLKAMSTIITKLAALMEDQVPTIMENVFECTLEMINKDFSEYPEHRVEFFNLLRAINLHCFPALLKLDNNQFKFVIDSCSWAFKHDNRDVEAAGLNMCLELINNIAEKTDIGTANAFFQRFFVSILQDVLFVVTDSDHKAGFKTQSMLLMRLFYFIHPADGTPPKIQGPIYTPDQAQAGTSNREFLAASVATLLQNAFPNLQAAQVASFVEGLFTLNTQYDKFRLNLRDFLISLKEFAGDNAELFIVEKEQQERDARAADMERRQKVGGLLKPTELDDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C353</accession>
    <name>A0A2T4C353_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1265900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C353"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="100" mass="11388" checksum="4C61B6C6E1FC752D" modified="2018-07-18" version="1">MRASDVSHYTISDVFVESPHATSACKPYSRDAKRQRKTPVNLVRQQEHRKTCSRSRTWRPIDRQSLLGHASRPSNMFHGESSATTYYIDEGDAIGSLHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3B3</accession>
    <name>A0A2T4C3B3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_313093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3B3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="161" mass="17672" checksum="99797D3E94C312C0" modified="2018-07-18" version="1">MSPPPSPRLLISGILWVGSPWQWHQAAEPTALNCSRATRTPGSESPGPAPRRYLIPTYSTLEDALQRHSPSRSAGSRHCALLRTLIKRNSAALSPGPVYAINFPEIHLQLDPRTRRVARCPTPPVIPRDSGEGSVKFKSPMAWTIGTCTYKVPEGTSNWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3D7</accession>
    <name>A0A2T4C3D7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1333612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3D7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3D7"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="11">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="148" mass="15663" checksum="3F3FEB0A39F44A0C" modified="2018-07-18" version="1">MSVMEAAVPLHVKKLSPQARLPTRGSAFAAGYDLYAAKDTVVPARGKVLVDTDISIAVPAGTYGRIAPRSGLASKHFIDTGAGVIDADYRGPVKVLLFNHADADYEIKEGDRIAQLVLERIVTPDVVEVEELEESVRGAGGFGSTGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3K9</accession>
    <name>A0A2T4C3K9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1246105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3K9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="208" mass="23644" checksum="E18A70B6CE6E51B7" modified="2018-07-18" version="1">MLMMGTSIGDGPSSQKVVSRATIPHHLQTPNCYQATGQSLTKPSSMSSRQRKIQKTNQIPLKAVHLFHSPTRHIVPLPLAVPLRSSAARHIHVKPSPARRSYITYRSSLFLCFHQGPHSKPLPLRKEKSQKKRETRRYPNWPLEGANLMHQLCKCRKMMKGEERRQACHKGSAWHDRVQGIQRQRTWVGAGRISAFAASSLFLSCLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3S3</accession>
    <name>A0A2T4C3S3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3S3"/>
    <dbReference type="STRING" id="983965.A0A2T4C3S3"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06197">
        <property type="entry name" value="FNR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="346"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="613" mass="67302" checksum="5931CEBE484D930F" modified="2018-07-18" version="1">MPSLVSTWHAGELAMHRELRNPRFENPTSHGCPTPYAIRVMHSPLVALGTLDDEGRPWTTVWGGERGFARPVAEGVLGLKSAVDKTYDPVYKAFWESSSDKSDGPDEEGIVRPEGGKMMSALSIDLETRDRVKLAGRLIAGADIRGLESEVQLAFHVEESLGNCPKYINKKTLETVIPQPELVPGGPGGMLPPEAVSLIEKADMFFLSSTNGVSMDTNHRGGPRGFIRILKNDVDGVELVYPEYSGNRLYQSLGNLKVNPLIGIVIPDYTTSDALYLTGRTTILLGKQASDVLPRSNIAVKITLSASRLVKASLPFRGTPDEPSPYNPPVRYLLSEKAPALAPTDRPDINATLIARHILTPTIAVFTFKLETPNPRTVLPQWQPGHHVTLNFETEVSHGYAHMNDDDPQSLNDDYVRTFTVSSPPGSLPAKDTFQITARLHGPVTRFLWRHNTRVPLDVQVLGFGGKDAFTLPVKMDGEEGQEPVYVAGGVGITPLLAQGKGVIDAGVPLKLLWTLREEDLALAVYALDRIPGLAERTTVFATGSFDGEDTQRLLEKVRERGADVVERRMSGDDLEKLRGRGRKFYLCTGPGLLKTLRGWLEGEDVVWEDFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3W4</accession>
    <name>A0A2T4C3W4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1333344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3W4"/>
    <dbReference type="STRING" id="983965.A0A2T4C3W4"/>
    <dbReference type="OrthoDB" id="4630416at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="432" mass="48503" checksum="37F556AD015DF8E9" modified="2018-07-18" version="1" fragment="single">ARLRGLFNPSTLRLKRDQKDAADEARRLFTKPFLAAQLKYYDIPFRPSHKRDELLLLLQNAVNQGKCDQVPQSVSDMEASLRADYAPLQQKANFDLHRFMDMYFLTDGKPDKSKNPEPMALSGLRQSWQLRTMAEGIPGLHTRIAYSRPDAEFCIGWDEDEVNALADRITERAREAERALKKAKWDKQMVRHKKYLARAAGRGSGRHKESFDLDRCVGSYIIQCPAIEDDWDLGDQTLTMDICKGKANSLWAAYHFGILEGTMFFSQSEDTLKAMFGDDLSDSAESHSNQDDCSDEEGGEEEKEGVIAQESARGKKRKSGKASPAQATTSAATGDSNNAKRRKTGGTPSPSRRVYFRLHGRETGEGEVLPDPDAGHIDFLSDDCATFAGLVDELTYVGTNVEFRGYKVSDTPRVKPEPWDTFCYGRYGLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3X9</accession>
    <name>A0A2T4C3X9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sure-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3X9"/>
    <dbReference type="STRING" id="983965.A0A2T4C3X9"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="774" mass="85446" checksum="DC869C0ECFCAF387" modified="2018-07-18" version="1">MHILVSNDDGPPSPHSSPYVHSFVRHLQKAGHTVSVCVPHTQRSWIGKAHLIGQTLKPVYYRPSAHSHGDESEGTTHARPSPSGAVEEWILIDGTPASCVQIGLNHFFQDRGPVDLVVSGPNFGRNSTAIFALSSGTLGAALEAAGSRYKAVALSFAFFSRNHDPVIIDEACRHSVRVIEYLYRQWPTDGSADLYSVNVPLVEGVETHPTVWTDILQNYWTKGGCFDAVDGSAEEDLEEERIREGPGGEVDAGSEVTDETSVPKGHTHKHFKWAPKFAEVYKSVEEAGPGSDGWAVKEGQTSVTPLKANFATCAGDRATKEIQLPESTETSTAELAVRQKPTEESKSKIRAIVSYDDPYVQPLIVSALNAVLPEDSFDLITDISPEDFNLSSRLPSPDARVVQIVPYESIDFEFASSHTKTCLINSYMIRKALIRKHYLSATLDHWAAKNPDSILKKHLKRSEAFEVDYAEFLDDALVEAFDLRESMDRNEEKEPSEREWWILKPGMSDRGQGIRLFSTMEELQDIFDGWEAERPDSDDEEDDDEAPGGGAAAAAADEDAQGDYITASHLRHFVAQPYIHPPLLLSPGGHKFHIRTYVLCTGSLDVYVYRHMLALFAGKPYTPPWTAPDDVEAFLTNTCLQDSPNENTVRRFWELPLERGVLEAVFGQICGTTGEVFEAAARAMPIHFQTLPNAFEVFGLDFLVDAAGEAWLLEVNAFPDFKQTGGDLRGIVEGFWRGVVGVAVGGFFGVEGVRRDAGEEGDMVSVRRIDLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4H1</accession>
    <name>A0A2T4C4H1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_4945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4H1"/>
    <dbReference type="STRING" id="983965.A0A2T4C4H1"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7538" checksum="8518DB3F26E5B3A2" modified="2018-07-18" version="1">MAGVATYTIAGRQIGGHYLAMGWLATLFGGAYYAASGPKKSASAAATPPINASSSDEADFIKKFLEEQDKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4K5</accession>
    <name>A0A2T4C4K5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_53596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4K5"/>
    <dbReference type="STRING" id="983965.A0A2T4C4K5"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="447" mass="48557" checksum="5D66F66C39957271" modified="2018-07-18" version="1">MRYLSSLLAASLVSATRFTHIHRSEASLPPSQDPFYAVPENITAFSPGEIINYREPPSQISAFGWTPTHIHKAYQILYRTTDSQQNATAGVLTALIPPDADYDKLLSLQMAEDSATIDCGPSYTMQLSSQSNPLLASNTTALQLLFAEAALAQKWIVIVPDHEGPKGSFTASKVTAHTVLDGIRAATQSNHITGIEPDAKIGLWGYSGGAAATQIAITMQGAYAPELDIAGVAMGGLSSLAEASDIFDINEGPSAGLIPSAMLGLATEHPDLQRAIDEALEPQFRDLFYSPLHQCLEATTLLFFHRDVLGMFRHDSIPGLKKELVKAWKRENDFPPSKIKAPLYIYQSVIDHLSDINRIDAEVRDYCDQGVSVHYERANSTNLSHVKYGIVGVYKAISWMQDRLDGKGASRKCVTLTDTTSTLDPNLAALFPKIISDALNAMVNGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C558</accession>
    <name>A0A2T4C558_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endosomal peripheral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1375853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C558"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1712" mass="186508" checksum="806D785D4D7808AC" modified="2018-07-18" version="1">MTTQLLATELANLIQESKRKHSDLRQAAEKSLEELKSLGNVPETAAPELLSQKPSFVNPFIIACGTKNAKFTGIAIVCLQRLIVAKALPRAKLYQVLEALMQASSAGLDVQLKILQALPSLLQNYSSDLNGDLLVTALNICFILQSSKNAIVNNTSAATLQQLVVSVFDKVVAEDKTGGDAPIAGEAPCTDGKVELRAAALDAYRIFNDLCLLTENQRSEFLRFSGLQQTFGLELIESVITNHAAVFITHTEQVHILRDRVMPLLMSALRGRPSFATTVRLVRILYTLLRRHITVLPTECGDALSLLTTLLDQDTTIWKRALCMEVFRGIFAEHALVRRIFAMYDAKEGDKDIIKTLIATFVRLSTEKPAVIGLGHQSTMPVADSSGSSNLSADQALIEASSVTGIIGGSVGSEVSNIGISVAWSSVRVPCIDQLDKAEAPTIPESYIYSLILACLSTLSDGLAKFILPLTVPNENRARRKASKQDMGRSSPAPAQLEAEGSSHGSRERSASFKKNPVPINPLDLEDHPAHSEVRICSDIVTECWPAILATCSTFLYASLDSEYYHGLVRAFQRFAHVAGLLQLPTPRDAFLSTLGKAAVPPNILSACVNAGQSRSSTATTPTETQNSVFSNARGLLSVENLTQVSSPTERQRPAPLDPSVTLNTRNLLCLRALLNLGIALGPTLGHAWGIILETLQQADFVLYVTGKAPGRAPSISRSGQDYQSESDGNSLMANFGSEVRSVETAATRLIESSVDFPNESFVEVVQAICGLLPGEGEAKTGTEDKEQPRQAQHARSSSGQHRRVLSFSGQSTISNQELQFALAKLGEVAMINLERLLRFDPKESGWEMLVQKLIQMLDWGVLSPPVRTRASEILAKLVLEAANAAGTLPADIRGAIQLRLLGALRDALKPLQKRGRDISVANATTDVEIHRIILDGLRGVIEDCGQTLVSGWDVTFDIIGSVFTTRVTDAADRESIISARTLGTRSSKLVRASFSSLQLICSDFLASLPNSCFLILVDTLYKFCSQDDDLNIALTTVTFFWTLSDFLSGNDKSLDITIDLFQGADVDRLERLAADRGRGSDAALWMLLLLRLTAVASDDRVDLRNTAIQTLLRIFDAYGERLSPEAWSICIKYVVFKLLASLEEELRSAQDEETDESDRTEWHDTAVVVLSGISTLLANNLEVLTAHSSFNELWNELLEHLATLLDFQVLDINTAIFKALGHVLSQSGNEEKPIFNETTVRFAWDLWSRGIPITKSPSGKAQDNQNCLIAYVAALREVYRLIKSDLTVQRVQRILSLLRHTVEEASVGSYATDIDNMTQLQAQVLDAVKMIRTDIGGVPSALIIQVSEFVTLAYDQDYQSQPPSKRTYVAMSKASMEMLEGLAVSHSTDADIYTSGSLNAALSALLKPIALKYQFPITTRSSQPWKLATSTALAIIEAALSKLDDLDLPTDTVQGIWQLIADIADGILSAECADPPPGTSIAEDEATDIAWFHKLVELIIPGMGSERVKEETRSAYAKSLFRTSIIHEPPLADKLAVDDGGAGLSKLYQPRAGLTVSVPPTHRTKMAYVAFEELFLLVSTDAPAAHKPSSAKATEDYSAARTRIACTAAPYLLLRCALTLRAYVSDQPLRGKMPQPLSQRKELLWTLQKLVGLQSQSEAIRPLEGAVSEGRKHLLRLYPLIVKALRVQGDAKVLSLLRDALDVVGGEFGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5H9</accession>
    <name>A0A2T4C5H9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1234663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5H9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="17895" checksum="17CEC593BA3DB385" modified="2018-07-18" version="1">MASPSFTYTHAAIEYYASLTPEHHHLHHTYIVNTQLTTTNKTPLIIVKPFPSSSTLRILLTNHRRAVPRLAQRSNPWLHPQPHQNRHHHWPRLNKIKVTKRKETQAQRAHREHLPPPCPTAAPAVASCRLACITVPVLLRLALPILTRPRDCQGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5K7</accession>
    <name>A0A2T4C5K7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein translocase SEC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1421885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5K7"/>
    <dbReference type="STRING" id="983965.A0A2T4C5K7"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="70" mass="7703" checksum="2A93CF72E3E6F7CC" modified="2018-07-18" version="1">MADQVEEILEVPREFFKDGVQFINRCQKPDKKEFLKLCQAVGIGFGVMGAVGFIVKLIHIPLNGLLVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Y1</accession>
    <name>A0A2T4C5Y1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1355286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Y1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Y1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="38095" checksum="BCCD0E83A2D1E366" modified="2018-07-18" version="1">MSIRTLRIGLIPGDGIGKEVIPAGRRILEALPSSLKLKFDFVDLKAGFETFEQTGSALPDATLDVLRNECQGALFGAVSSPTHAVKGYSSPIVALRKRLDLYANVRPVKTVMTAAKPIDMVIVRENTEDLYVKQETTRDTPEGKVAEAIKRISEKASFRIAAMAGDIALRRQKIRESSPSIHGKPLVTITHKSNVLSQTDGLFRTASKNALSDPKYASVSVEEQIVDSMVYKLFRQPEAYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGEGFAIGEPCHGSAPDIQGKNIANPIATLRSAALMLEFLEEPEAAAKIYAAVDANLEEGKLLSPDLGGKATTDEVVEDILRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6A2</accession>
    <name>A0A2T4C6A2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1401443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6A2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6A2"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002463">
        <property type="entry name" value="PRK01683.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="272" mass="30627" checksum="ED1D9924B2123716" modified="2018-07-18" version="1">MATQATSQGRAANTKDWSAAQYLKFAEQRTRPSRDLLAQVPLASPNRIIDVGCGPGNSTEVLAKKWPNAHILGMDSSPNMIETARKALPNLEFTVADLHTYKPEGPVDLVFSNAVFQWIDFEHRIPILRRLLESLQPGGVLAFQVPDNHTESSHRAMRVVAENGPWSETLGRLKPSLGPFQTPLELYNGLKPLCSSIDVWHTYYYHPLGGHQEIVEWVKGTGLRPFIDPLESEQRERFLAAYLEKLKELYPLCDDGTVLLRYPRLFLVAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6D4</accession>
    <name>A0A2T4C6D4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1376690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6D4"/>
    <dbReference type="STRING" id="983965.A0A2T4C6D4"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="57"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="386" mass="43116" checksum="B6486804910A8EE0" modified="2018-07-18" version="1">MSSVTASARDLALEYISAPRFTQKFSLPDGENQGAVTISFADVGFKPEDPTASRSTPTVLFIPGMFGSTYISAVLDRIAHRYGVRVLVTDRPGMGLSTDVPLSQRIPTWIRMLPRLLAHLDIPHVALVAHSAGTLYLLNTLYHHRDLLHPERPYVAFMGPWVDPARSKSTSMQMLQYIPTPAFSIWHRIPRFFVVDAAPVLTTSGTVLNKATSLFSSSVGTDVQELTTLEKNRQRLADEYDFPRDLQMELSIIITKKIFEEKTVGANSEALQCLRKGQGWSWGECEDYGVLVETLVSAERERRQSNPDWRDSMRLKVRAYFAETDIMIGAGGQKYFEEIWGSKDKAFDDVLDFESVTVPGTDHDSVMQPVEVLEQVFIGAGGSLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6R0</accession>
    <name>A0A2T4C6R0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1421037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6R0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6R0"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF361">
        <property type="entry name" value="TRANSCRIPTION FACTOR SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="360"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="589" mass="64968" checksum="8C269705BDC084FF" modified="2018-07-18" version="1">MSGTEASAAQGGGGNNASEFVRKLFRMLEDPSHQDVARWGKDGDSFVVVEGEKFTRSILPKHFKHSNMSSFIRQLNKYDFHKVKPSGDGDSTSPNGNVLEFKHPYFRVDSKDDLDNIRRKAPATRKPQVAEDFTTSQHVSVISEQLTATQQQVQQLQELFADVSQTNRLLVNEVLTLQKMLNAQKQAQHEMLNYLSPYNHSRNSGMMGHSMNSNGGMPTSEGDEAVPELRRARELLSSVAPDTVADRELERLHDIYESPADSATMVTPVSMPMMHDPMNDISRYPVYPVGQTVGIDPFHSDHINKIPYAMPNEGSSGSLDHHPQQQHTAQPGASNQMNSASGPAESMDKPASLWGPKKPVVFLVEDDGTCAKIGIKFLKSMGCEVEHAINGVEAYNRINAVGRDHFDLIFMDIIMPRLDGVSATMYIRQHCPTTPIIAMTSNIRPDEVNGYFEHGMNGVLAKPFTKEGMLKSVKTNLQHLLKNPPNQSDNGHGPGFLMNVPYLSTTGNPIKFESPTPPAGTSGSNWPSGHMPQNGVDQGFGLMDGSSQYNMTQSRGAYSTMDASSGRLSDHDSPPEKRQRLNNSQRNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6T0</accession>
    <name>A0A2T4C6T0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1400179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6T0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6T0"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="92" mass="10385" checksum="C3DA41BBEC24EE6C" modified="2018-07-18" version="1">MTRAQQTISIGLLVSSLYLALFLELIPLPPLVQQEIVPVLPFWALISFGAFLLFRLGWGVFTFNDVPDAHKELMEEIEMAKVDLRKLGVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7M2</accession>
    <name>A0A2T4C7M2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1216586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="2"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7M2"/>
    <dbReference type="STRING" id="983965.A0A2T4C7M2"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="71" mass="8158" checksum="940001E6927F00FE" modified="2018-07-18" version="1" fragment="single">MPVTEFATKERYRYQNGFNNHLESEAIEGAIPTAQNSPQKPPYGLYAEKLSGTAFTAPRHDNKQTWLYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7M8</accession>
    <name>A0A2T4C7M8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1330302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7M8"/>
    <dbReference type="STRING" id="983965.A0A2T4C7M8"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF2">
        <property type="entry name" value="NEUTRAL PROTEASE 2 HOMOLOG SNOG_02177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="51" mass="5581" checksum="DD5FF1675C8BF0E6" modified="2018-07-18" version="1" fragment="single">NIHEITHLTQVKGTQDYGGYGYNFVQSLSAAQNLNHADTYALYANAIYAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7V7</accession>
    <name>A0A2T4C7V7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1330881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7V7"/>
    <dbReference type="STRING" id="983965.A0A2T4C7V7"/>
    <dbReference type="OrthoDB" id="4826573at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="316" mass="33667" checksum="C3A1775685792A9F" modified="2018-07-18" version="1">MPLPGATHVFAAGLAAPPVTEALERLVLSHLEQAALRVQEATGVSFSPSDQSPSESCPAAQQDVAALVTEMGDYLARTAMIWSCLIQSLIQGPHIDLVTLQILQKSKADTRVADLSASVSMDVTLSRLRKMRDLAEQYSRDVQAVWRIGGHRRPSLSCSRAREPAAKPMPLSTPMVTIPTAMPATTSASVATSESAATPPAAESSPISVATPASDATPTAATPNEQDESDDYSDENQFAGINMKALKQRGKGKYYCPRGHHCDKGGVDKQGNLVLFDRNSSFAYVAIFPHPARGDEPSSCVSFLARLQVSPTPSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C877</accession>
    <name>A0A2T4C877_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_3902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C877"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="203" mass="22309" checksum="42D2776B3BCB9E3B" modified="2018-07-18" version="1">MSRNTLKIPSCGQRRDYGQLEVQPTNINTSTNARSDPTTASLRTLAGTALQAEAYPYRHGHLSAVGPRSRRGPLARAGHDAPTTENRSGCKALVYALGIESGTRRENGSSQARYGAIRDPPMTSGTGRVHALALGLMSISRQQWQITADAQRGPLASFSLPNHWRSLSPVLAREDFEQQMTIGRAELTRMRKRLSALSRYRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8C4</accession>
    <name>A0A2T4C8C4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase ESCO zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1400755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8C4"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="2">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="304" mass="33391" checksum="34086936B11177C9" modified="2018-07-18" version="1">MVTSSPEYSITKPGLHHVRKRAKPLRTYGRQPSAPEDRSEPPPKKRRLSALKQQDQQQEEKPGSTPESSNGAPEREATPPAPLSETKAATHDASNQTKPAAKCAPSSKGSILSYFKPSSAPPNSKDETQPPPPPPQESNPQPEDEQSIPPDSPPKRKQPSRRKPRLLKIKPVTHDPLDEPSEEQDETPRTSDETTPQSSTTLNAHTKASKPNASSTSTSRSTSPSSPSSSSRKTSLRSHQKPRPSKPPPPSVQTTLNISAKAAFSECKICDTVWNPLYPDDVKFHNKTHKAVLRAQRKRMMDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8K0</accession>
    <name>A0A2T4C8K0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1227307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8K0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="21542" checksum="83B2E6980653FA22" modified="2018-07-18" version="1">MEKGCTKQSGRQASSFLPPWGIPGPESDTGLALRRTIQVGTHFFLFFLFFYSFLFPIFLLGIYKALLILYSLTHLPLNWFFFVFLALISAWNFFSIVEVLLLLVSDFPLLLISTSPPFCVFICPSDTYKNLRILGWLIWGSFLFLRCLPFACNDLEQERQKEDVTLPFSTYLRLQAFVGSVQECCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9H0</accession>
    <name>A0A2T4C9H0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1399351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9H0"/>
    <dbReference type="STRING" id="983965.A0A2T4C9H0"/>
    <dbReference type="OrthoDB" id="4900696at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015400813" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1085" mass="102669" checksum="914030A787CB12FE" modified="2018-07-18" version="1">MKLSTSLILVAALAGSSVAAPTRSSALQARQPDSDALILLASHISTGQLTQSDRQLLNSLLVTASLGKREEAGTFSDLGGSFGNTLGTSIGSVIDRLLSLLNSLLSGGLGGAQGNGSGLNLGLGGITGTSGGPSLSQLLNELGIDTQGNINLNNLVSRLGLAPANLSEILRQLGADANGIVPLSTLLSRLGLGSNIGNLDLSNALNNAGGSGGNGTLNLNGLLRGLGLDDNAVPSLLRSLGAAPNGDISAPDLLKGLGLTGQGHVNLGSILQGLNGAATRAGLDLRNVLNGLTGILNGLSSTVPSGSTTNVPVTVPSGNAAAAAVPNLSALSNSITNGIFRGLIGGLDDATIKDLTNIIKAANGNTQIATDGIRLYAAVHGLDADALFQSLKNVLAFGSSDDSLGKALEDSNGLLGGLVAALDGLTSGRGGLSGIGLPGIMDQGLGTLTQALQNVTNNSGTVTNGTASNAPRLTREELQQLLDFVRNATSQDTVTQVVTQFANSHNLDPVALARLLQALLNASNTASGNNNNSTGTSNTSVPLNVGPVLNGTLGNLTSILGGLAGGSNGGINPAGGVPGGLLPNLGGLNGTLGNLTNILRGLANPTALGGLGGLGSLGGLGGLTGQNNVLGLRLALALRIAILLGGGSAGLSGGLGGLGGLGLGGLGNLTGLPTGVLGNLTGGLGSLPVGGLGNLTGLPTGVLGNLTGLLGSLPAGGLGNLTSLPTGALGNLTGGLPVANPAALLAGLLGALSAGGLGGLTGLPTGALGNLTGLPTGALGNLTGLLPGALGNLTGALPAGSLGNLTAPLGNLTGDLSAALGNLTGGAPVANPGNLIGGLTGALPVGGLVPSPNVTGALGNLTSNPAAIIGNLTGAAGNLTGAGAGAGLGLGLGANLGLGLGAAAPALDLGSIISAVGSTVSGVGSGLGSTVAGLGSAISGLGSVLSPVGAPLGSAAAGSALPAAALGAALTAGAAAPALAADVAAAANVAAAANAAAAVAGLLPSLNVTANLGLGLGLLNSTAPGLGLGLGLSAQGLATAPPSDKAALPFHPSEADEEASSRSKVRRSRAARFRGAARKANAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9V0</accession>
    <name>A0A2T4C9V0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit Ten1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1399502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9V0"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13085" checksum="03F3D1273C964CD6" modified="2018-07-18" version="1">MSWGPVPSKLCLLSQLRDVSVGDKVRFLGCVISYDTATACLTLGHMYPPGTNETVRVNIELVLETIQPGLTQVGQWVNVVGYIREGRGSPVRVQALLVWLTGPLDLGRYERSLQDQMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA16</accession>
    <name>A0A2T4CA16_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNase1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA16"/>
    <dbReference type="STRING" id="983965.A0A2T4CA16"/>
    <dbReference type="OrthoDB" id="3513524at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015635674" description="DNase1 protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18105" checksum="693E658DEE1A5164" modified="2018-07-18" version="1">MRFAASVATLIASAALSSAASVTFWTLDNAQRTIYFTSNPGSSNIDSVKVSSDKNTTVTFPDTWQGNFYAVKEGANNVPGMLGEINFGSWHGLTYFDVSAIVDPNDKDNVKQMFPAKSLEPMSGCVNFPCNNAYYLPDDIQTKATQEQELVCTLGGGHIGHTFTEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA36</accession>
    <name>A0A2T4CA36_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_261837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA36"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="169" mass="19023" checksum="C63257B7DDE47E1A" modified="2018-07-18" version="1">MFIWRGIIDLRRSITYSRCLRSQQHPLTVQGRKRARSKPPISRLPPSRPALSHSLVLSTLGQEKSNRSWIARQLLVPLQRRISRPQHSCTKAFTGRKGGPVSLLLWLISLPPLAPLPLAEPFDRALLHRGAANNGLLLARQAFPPTSGLCREHPCLLASSYGNKRQWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAI3</accession>
    <name>A0A2T4CAI3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1328239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAI3"/>
    <dbReference type="STRING" id="983965.A0A2T4CAI3"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="642" mass="72423" checksum="2B860D03A27F1240" modified="2018-07-18" version="1">MNKVIMGIAFYFGLNIFLSFYMAKDQTGVVTTNPETGETIVVPGNMGKIPPYQLRPKHLDEGATYRHIPKTIAPIWPQDSYVDVVVTISPSPNPVPLAQVPAEYVVLNESRFHMNNKTDKRSVDTTFTVPEPVRNNGTLWGHFYIGLSGSVLDPYQPDFDPGRAYHVAHPLTQYLPKKKVAKTRNLLEDLPAPAEEPEEDTSGPVIASYYHQNASFSLVPGLGVKDLDTVHPALKRFLRLEATGARDGSGQNGWYYPTLFVNTFWQLKSQMTVLNDTVKELPLHIDLDNMPGWKFYAMAAVEQNSKENARQAALGNPVPGGGDGSEIEMIKEIFIDTNPILLGITAVVSVAHMILETLAFGSDIAHYRKKKDNVGISVRSILANVFMQTVIFLYLLDNSQNTSWMILGSQVVGIVIEFWKITTVVNVRFRETPPGSLLPYWFVFEDKHKLTETEEKTKEYDEIAFKYMYILAVPLLIAYGIYSLVYESHKSWYSFVITTLVGSVYTYGFLMMVPSLYINYRLKSVAHMPAKAMMYKFLNTFIDDLFAFTIKMPFLHRLATFRDDIIFFIYLYQRWAYRVDYTRVNEFGQGGDDDEPVTEKKKVEGDKDKAAEIQEAAVQDAVGEKEGATATGADAGQVTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAP5</accession>
    <name>A0A2T4CAP5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1420714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAP5"/>
    <dbReference type="STRING" id="983965.A0A2T4CAP5"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="737"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="894" mass="97980" checksum="F90FF6F7C1C37A34" modified="2018-07-18" version="1">MAATAESQQLSNAILSFALEGSFPEDAAALHSVSETDLNPTIEALGKAKLDIEAEIHTINEETKDDISSWMRNAKVLQEDIIRSKTIANDIIRQSEAPEVTGEAILDAEEKAEFLNREVQYSQQIHGVLRRIRQVNQLLAEVELATRERRVLDSLRLLEQSWKALDDVGVSKTTRVMKLLDLRAFELKSDIHQVFNHVWKTLVQADTEAGKVAIYNTRQDEVMSLEDAVIGLKAYREVDERMEQLWHNLDAAVVSPRMDATRSSIPGIRVEGDVLELAGFSDGSAESLLSDLQQILKFVAQKLPADLLRPLADVMMGDIISKLTKGWLNPAVPSGLKDLDKFQALVSKMKEFCDTLQHSGYTGLEQIQDWASKAPTIWLEKSRETALDSVRVKLAGGIGESKRVEKIERQMVSIAEGKELSRTGAGAVADSNDWGDDWGEAWDDEKAGNDKEQAPQMKGQDGNHGEDDDDGAADAWGWDDNDDANKDAKKPDGTEPAEAANEDDGADAWGWGDTGDANGPKNAGAKDAADAPAEDDGADAWGWGDDGDAPEEPASAPAPVPAASAAKAKPAKAKEETRELVFKESYSISSMPEPVLELIFSILEDGAALTKDGSEYGLLTATAPGLFSLPTFVLALFRAISPHYYSSVAGGNMFLYNDAMYLSEKLSDFSAAWKQREDLTPRARSMLRIDNDVRTLKSFAIRSYSNEMSLQKTILQDLMGGSQSLAQQDDKEASIEAGTARIRSVAATWDPILRRSVWSQAVGSLADSLASKLISDVLEMPSIGQDEAYSLAQLIASATELDDLFLPSKLAGTAPVPDELPTTAQYAPSWLRLKYLGEVLQSNLNEVKFLWCESELSLYFTVDEVIDLIHASFEDNARTRETIKEIKAKEPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBE4</accession>
    <name>A0A2T4CBE4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1399964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBE4"/>
    <dbReference type="STRING" id="983965.A0A2T4CBE4"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB78842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="217" mass="21696" checksum="805D843AB876F161" modified="2018-07-18" version="1">MSSNKLGKMAGYINYRMRVTLQDSRQLVGQMLAYDRHMNLVLADTEEFRRVKRKNKSGAPGGSAGQTVVQEEKRTLGLVIARGAHIISLTVESPPPADPSARLGKTTTGGIASTLQAGPGVARPAGRGAAAPISLAGPAAGVGGGVPPPGFPSFPGAPGAPGMPGPPGFGGRGAPPPGFPGQFPPPAGFPGAPGFPGAPGFPPGGPPPPGFNPPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBP5</accession>
    <name>A0A2T4CBP5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_225494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBP5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="62" mass="6880" checksum="B67D5E6B127F6537" modified="2018-07-18" version="1">MPCHGVLNRRQNRNSRARGLFVSQDGHSTNTLHPLQPPPSSSYLFSPDPPREPTRTGATHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBY8</accession>
    <name>A0A2T4CBY8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-terminal binuclear Zn cluster-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_64259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBY8"/>
    <dbReference type="STRING" id="983965.A0A2T4CBY8"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="686" mass="74501" checksum="22FB9AACD16F4E6D" modified="2018-07-18" version="1">MSSGVVRSTALRAGGACVRCRKGKTKCVYENGRAPCKNCAKGMHECYLPSESLAHHHGHSPARHTAAHRPRDALPASGPGASDARQPVVGSGGARHAQATSEKLTPELIAECERVVSKTFPACVAFHKPSFVQQLKNASLESSLVYGLLTCAARSSPTLIRRYGGNPTAAAETFAAKAISLINSNLDQPSLADVQALCLVIIHEWGSRNAVRAYVYLGQAARLLQMYRIINSHHAPDQTDPFLRDESFRRTLWLIYILDCLLTCTPGRYPALAIQDTAEVALPCSDINFAFGNTVYVKTLHQQLAQQNNHSSPSHVPSGEIGEFGYIVLAATIWRDVVGTLGLSPFREDDCTDLIIKIERLKASLPMQFVDKPGQINLHMTMGSGYTYAMLHCLIHCATIFVHRRRLLEDVTSPSFNLEAYRMTSRCHDIIDRLLTSCHGTLTLLTAIESGAEKDHATCFPIFMLFSAFTASATVAYLSLKRLTPPNAVETAAHIVKDGLRFMRDGNESWPLLNSWLRHLTVMQRVLNSSQGTPHESHSHMPSASIKDEMSSNADTNPDAMEYDQPAAGVTPGQQGAERRSVSGSARGESEPPIALPRRPGVTTINGNNIATPEAVSTPPPGAPQANMQVHDVKQQSPEDAQNGMPSSHDGGQTTSQDMTSPELCLAFERQLMDHDDLAAFMGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC07</accession>
    <name>A0A2T4CC07_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1419519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC07"/>
    <dbReference type="STRING" id="983965.A0A2T4CC07"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="103" mass="10789" checksum="C3A2A04BD3E4CA6C" modified="2018-07-18" version="1" fragment="single">MPSNLPSSFASAAAGQNASRDARGGRSDGRPSAGGEWSRRDGRSANGTLTFRRSSTTPLSQSSNPPPANDNAVQPPSVEEAPLAQPTTYEIGPSRYSKDDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC31</accession>
    <name>A0A2T4CC31_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1398351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC31"/>
    <dbReference type="STRING" id="983965.A0A2T4CC31"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="122"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="278" mass="31695" checksum="E3B3141ACA4B78C6" modified="2018-07-18" version="1">MGSVDTSIHPSASGAAAQLAARHADEQPLKLYAGWFCPFVQRAWMTLEEKKIPYQYIEVNPYKKEPDFLKLNPRGLVPTLGVPVDAAGTQQKPLFESSIIMEYLDEAYADEAEYGPRLLPGNPYQKARARLWIDHINSRIIPAFYKFLQHTPEKEYSVDEAREELHKQIKTLVAEMDPEGPFFLGRDFSLVDISLAPWAKRLFLIDHYKPGGLQIPKEGGEGNVWTRWSSWMKAVEGRASVKDTWSEEDKYIDVYKRYAEDTTNSQVGQATRKGTKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCN0</accession>
    <name>A0A2T4CCN0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_48497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCN0"/>
    <dbReference type="STRING" id="983965.A0A2T4CCN0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="196" mass="21661" checksum="CBECAE0FC6DBAEF0" modified="2018-07-18" version="1">MEGGALTDVIDNNPSISEEQIATICHETCRGLQHLHAQSIIHRDIKSDNVLLDARGNVKITDFGFCAKLTEAKSKRATMVGTPYWMAPEVVKQKEYGPKVDIWSLGIMAIEMIESEPPYLNEEPLKALYLIATNGTPRLKKPEKLSKELKAFLSVCLCVDVKSRASADELLAHDFLQHGSGLASLAELLAFKRNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCR6</accession>
    <name>A0A2T4CCR6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1327063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCR6"/>
    <dbReference type="STRING" id="983965.A0A2T4CCR6"/>
    <dbReference type="OrthoDB" id="4940504at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="460" mass="46579" checksum="CC4CFF042CC5763A" modified="2018-07-18" version="1">MKDIKDAECGVVPQKKMGVARKIKENLLDFKFMTSAGMSICALAALLAITFLAAHCAGLERLYQAHGAVIVASDEAIPVVDHKLERRAADCNETESAMSAASAQVVTLVLDDGSLAVVTQDSVSYSAVSVTSIPISTQTATSTIYSIITPSTPAVVTKTLTMTTSMFTSEAPICSAIDTTVTVTVTVQPAPSPWASSSVLGDVTVTGGASTVTNVNTDVSYTSGLPDATVSGNPSTVTNVDVSVTNLPDVTVSGNPATVTNLLTDISLTSGLPDATVSGSPSTITAIQTSYSLPREPVTSLVTVVISDLWSPPASSPLSTDLVTVTAVSTLKTTVTTIGTAPSPIIVTVQPPYVEPTSTTTAFDSSKAGAETFGQSTLIKTVTATTVQSATSTTTVFMTPVVSSYNGTAASTVPVGTAASSSALPSIPVVVSGGNNMGNEAQGRILAGSILAVAAVMAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDM7</accession>
    <name>A0A2T4CDM7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1327292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDM7"/>
    <dbReference type="STRING" id="983965.A0A2T4CDM7"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015511578" evidence="2">
        <location>
            <begin position="20"/>
            <end position="765"/>
        </location>
    </feature>
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            <begin position="303"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="739"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
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            <end position="337"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
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        <location>
            <begin position="475"/>
            <end position="645"/>
        </location>
    </feature>
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        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="765" mass="74497" checksum="838F8B1DF7C68B75" modified="2018-07-18" version="1">MRLLTSVSIGALAGAVVSAAQPEVRRVYRKEVTDIRVLKVDNGELVPTPTHPLELRHAAVTTLVAAPSFKVTLCPEPTGSYAALTTEPDLTYGCKPGFVCNPPKPDGCNFWPGPPPKEFQCQPEYCQAACPLDLVKWEDGKTGYYPPQNGYFNLNPEQFGLSYDIFEYSVVRKASEGRTSTFTTGNWESQSTLTDGPLQTYLPGYKRRAYSPDKPQVRRKTSSLAKRAPLPAKCFDSCNTAVLIAQKDGKIPELCEDGSDFLNAFNQCIDCVATAEGIPKEAVEAALDPPFSQFLFFCGGGGTSPTQSTTSAPESIVTTTPTIGTTTQVSASPTTFIETTTSSPVESTTERSTTAPPPPPTTTAGSTTSPGSTTSPISSSSSSSSISSSQESTSTPPTSSSTPPPPPTSTSTTDASSQPPSSTAASSAPPSSIAPSNSASQPPSSTESPSASITSESASGPGSSIPGTTPTSVNSETGSVSASVSASGSASGSASGSASASASASESTSASASASNGATATGSSASSATTGETGAVPPPTGTTSPTGASSSAGAGSPSSGTESPTSSAGSSTGAGAPTGTDSSTGAGSPTGTGSASGTEPPSGTGSSTGTPVGTGTSVETGTGSSAGATSGTATGAPAGAGSSGAAVTGTAIQTGTNVSSTGFSSPGQLERASSTSPGLPGGAGGAEPTATSGNGGQGGNNGGAGATGVPSNGGGNNGGNGGNGGATGTGPITSPTGGIPVSNDLSRLSENFGLLVAAILGLWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDP4</accession>
    <name>A0A2T4CDP4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1176383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
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            <begin position="361"/>
            <end position="406"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
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            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="517" mass="59734" checksum="03F2C5895552E28D" modified="2018-07-18" version="1">METRTETRVGEISPQKSRSSTPRRRKNGRYRRTPSKRHTPTPHSSPYRSSKRTSKSRTPQRGIQSPLKQRRREHEDEVKVDTRDERIINGVDEEKDEAKEKNSDEARQQGGTIVGEKMLADMEAEKRHYLGPDLRWAPLEERLFEILFLRQEIPLLPSYWEEYFPTFPMPEGCYCWREDMHPVVYEHANNTFRATAALTRVIDLTADIRTTCQSGLRSKAPQMIKKSLGKFLNWAAEDGGYRHLEYVPNIIVEIVDMRREDMPQTAFVEMRMRDLARQHRKMLAIKPEKEDDADEGDVDMEVDRQVRDEAEASHEERQKQQAVASRSRSWRIFGSRVMNRLFRLIRRRSVIKPEYHGETNVIESDADEAMTGEGETPESNTVNVKQEDDEYEGIQVTFKREPCSESEDDIAMADIPLASSSAANSSSSPTLYRRQPPVIFGFFIVGTEVMLFTADSSKEEAAMNLTLQLILNFEDRSLSIWNALTVAIVACLARDDMMKRMDDFEEARVVEESDPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDS5</accession>
    <name>A0A2T4CDS5_TRILO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">M440DRAFT_1436928</name>
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    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CDS5"/>
    <dbReference type="OrthoDB" id="5368516at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="480" mass="52912" checksum="5CDC5EF4B99F7DF2" modified="2018-07-18" version="1">MDNTTSSVINSLRFDVARQVRSMIIILAGFNVAMAFVLAIIIFRNGYKATRTSDPAFGFRSSFIKYIEMSEVFPFILSIGIVVQGIIYAASQTKGLEGLLSLGCTSISQAMLPALFVVPFIQLVFGLESTVQALRRKPFQQRPRWVIVACLLIVVTGILVMYVQTRVIRPPDLCYASLFWFVQTWRLECFALLTIIGCAMVIGAIIVFVRLHRDASIGIIERTAATKMVYYMVLGAVLNGLMAPFFFSISAQNPLALTNIQLSLNMVGSVASNVSGIAFGVLYLFLRSRKMQKIGPLGHVELGSPTREKYTESWRETQIYNTQIDQPVSPVNVLESRRRMSILGSSGETAKLTIGRSGSPAAAHVKSSSSRDVTDDSIPPVVSPTQFVTRARKDSYSLFPNQREALESQPRGATTLPSTIYRPDAPMAETERMSNMNEMFGELLPPPAIRVSGAPRHNRESSLVSSATVQIGLRRSDFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEL2</accession>
    <name>A0A2T4CEL2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1108046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEL2"/>
    <dbReference type="STRING" id="983965.A0A2T4CEL2"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="503"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="716"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB79996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="771" mass="80088" checksum="73DAB2D42965736A" modified="2018-07-18" version="1">MNIDDFIFAEEGGASVKDNSPQPTASSHSGPQTAATKTSKSSRPLASAIPIKGRKGSSANQFVAQSVPVAPPHQRGQFDEFHYVPRHDRKTSIDDRRTRKRPANFSPHVSAINTNASGLSLELEADLDLNGYSLDNTNAMPMQQQMANNQGSAFNLDFMDSDGVLGSAPFHQNFSFSPSTSPLMHNGPFPSVYNNAALQSSLNNPDFYSPTGSGYPSATSTPHPMNEGDGVYFGSQEMQHHQHHRAQGFRQSSGNVNHRLNHQFMYGDSNAGSGSGNGAAFPSATTSAEAVASYGAAQNSFRHIDPSQVFQTDSQVASPILPLQQGNILGFGGESDEDDGNAFLDRGGVGLHGDFTSAVDEAGTFSWDASLPGQFSTQAARFPGGPTRKHVQIGSITTDYVDTSNDWDGHNLSRSHSQTLGMSNDNRQSKLPRNSSTPSHMAAKHSGFEQIAQSLPSSPGPHASGTASGFSSVAPSRPASPPPASKHGSSTNLHAASGNPGENSAPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRGSGANLPVGGSRKKNAGNGSNAASRKNSSLSMAAAAAATAAVATANHQAVTPPSANRPSSNKEGDSPASSGQQTAGSTPGSQYGGATIVGGKGVVPIAAAPPKTTPGPGASSSMSRPATASSKRQRRHSKSEGASSSAMELDGPGEPMGRPLGPTPSMPSISSTMLSNGSFSMGQRSMMGSSMVSMGGSQGNLVNSAGGSSGPQEWEWLTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEW2</accession>
    <name>A0A2T4CEW2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1388466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEW2"/>
    <dbReference type="STRING" id="983965.A0A2T4CEW2"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="364" mass="40098" checksum="97AF4F98BB51E8CB" modified="2018-07-18" version="1">MKVPTRIPLQLALPRSQFVRPFHQSIARAANVAPIVGAGPPPDPPTPAARNAQERLERRRKHAQLLKTAKEIRSAQDGKSETVARRFWKEVTVREVDGALQVHLDARPLRHPTTKAIIRLPLSKPNLASALALEWDILTSAQQATKQHLIPLTSLVCRALDILEDDASNGPEATKIRTTITNTVLRYLDTDSLLCWAPPAGPHDRVNEAGESLRDVQKKAAEETVSYLTTHVWPGITIEPVLDGHSIIPRKQGEGVREVIQGWVMGLDAWEIAGLERAVLAGKSFVAAARIVAEWSEGAVGTGRVLPLRQFSVEQAAKATSLEVDWQAEQWGEVEDTHDVNQEDLRRQLGSVVLLVSGTGKQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEW4</accession>
    <name>A0A2T4CEW4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1111954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEW4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="178" mass="19681" checksum="CC2373A662963226" modified="2018-07-18" version="1">MISSSIHLASSPSHSRSSNPPARWLRCSIRRDAHSLSESRLPTSLGSLFGAEAGATRRSSSTTPTSAGLYYCSGPPGFEAAKLLLSALWRSVHQLRDAYSRRIKRVTRGGRALRRDRCRTTCFRAVSACMKTMRGGTKNLTLQSPFITLQQDMRKSFVAGMDIMDIMEHQPSESTSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFB3</accession>
    <name>A0A2T4CFB3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTH-type GPCR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1435890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFB3"/>
    <dbReference type="STRING" id="983965.A0A2T4CFB3"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="35"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="336" mass="36730" checksum="5A92DB237EBC62D5" modified="2018-07-18" version="1">MALQTVTFPILPVVRTHIIINSILVALAVVIVGCRLYARIVTGAKLWWDDFLILVSMPLGIGMLVIQGLYAPMGVGRHISETQENLVIILKLTIAYALTYTSCITIVKLSILCFYLRVFPNSKLRIATQIVIGIVSLWGLGSVLMFFFVCRPFEATWNPLAGGTCSDRIATFLAVGAYNIVSDVIILALPLRTIWTLNTRSQMKVALTVLFLTGLLVSVVASCRVITLTHLHMDNVTGTMVWADFLSTLEANLGIICVSLPMLGPLVVRYTKGRGANKLGRCNTNHATTVSVVQASSPDGSQTQLNPLQRELSGQPRVRGGAILVESKWEIHRSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFE9</accession>
    <name>A0A2T4CFE9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1467597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFE9"/>
    <dbReference type="STRING" id="983965.A0A2T4CFE9"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB80291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="137" mass="15828" checksum="45BE3C001E62E2BC" modified="2018-07-18" version="1">MGDRLTQLQDAVDQFAQQLVACMHFVQMRHDLEKLGPNDKIREPKEQAQKEVDALPPQDFRAGLVELSRDLIVKEQQIEVLISTLPGLDNSEQDQERHIRDLEEDLKTAEAQRVEALREKDLILAQLDAIIRNIRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFL2</accession>
    <name>A0A2T4CFL2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1397709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CUE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFL2"/>
    <dbReference type="STRING" id="983965.A0A2T4CFL2"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="198" mass="22036" checksum="A14191B11F5C6474" modified="2018-07-18" version="1">MSDEQISLPFFAIVLLVSGLIVRYLFFSGPRPERPPVRTAEQLIRSREVAVQRIQQMFPQVERRSILWDLQRNGGNIQSTTERILAGRLETPPITFQPPPIRTQSPSSGNSGSAAKQPEKPAQPDLITRYNLKSKVSEAAATEDGGAQGEQDKKGKGWSSNREERQAALQRRRDEMILAARRKMEAKLAAEKAAQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFT8</accession>
    <name>A0A2T4CFT8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFT8"/>
    <dbReference type="STRING" id="983965.A0A2T4CFT8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="275"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="382" mass="41920" checksum="10910C9DEBC874EF" modified="2018-07-18" version="1">MENTPPQEQEHHQEQHLGGQDHPSQPVLPPPAEANSGSERTKKRPRASTSAVCDSADEDHDAKRRQTSDAHDGVAVADTTGNATASTAKNRIATRITFANETAATIAEHINEAAEYASKEGRGAAAEAMQHSTEFQPHILQMENVPDVAAVAAVAAAAAAAAAEDEEERSTIEASGGSTSTSDFVPTEASTLDASSDNSSIHQSSPRSASHGSAALEAENQVNGSYTTHFESFAEWQAFLDGDREKPYPYWASQPNSDCYALTWSTLPKEHKSVVIELFRGAGREAELDRQILGWSIAHDHHRVEISVHYPVIYGDIANFHRKKIRSFDFNDPKCDRWTAYRFTRNLYGTWMLAHFARVCSAIDDLPNKWPRYVDSIDGFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFY0</accession>
    <name>A0A2T4CFY0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Utp21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1348486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFY0"/>
    <dbReference type="STRING" id="983965.A0A2T4CFY0"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000565">
        <property type="entry name" value="Putative snoRNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="61"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="618"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="703"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="834"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="866"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1042" mass="113556" checksum="0CCF9F1F8873343D" modified="2018-07-18" version="1">MPHSDPEGPLAKRQKVSTLANAAQPSSNSSRIFAPFRTVGLVAPSSIPFTSFPLGKTTFQITTSVGRSLQTYDLLRGLNLVFVTRPQTPADITATFAYGKKVFAAWGGSQDGEPQGLWVFQRGRKVDEVVLPSDLAEPIQQIMIFGTWFIACAKTRIEVYKTATLEHYTTIHTMAAAKGGHEITGGVVTMPTFLNKIFVGRKDGWVEIWNVSTGKLIYTILPPTPDSGAVTCLEPTPALSLLAIAYSSGTLVITNVLTDKRALQVEAGNPDAPVTSISFRTDGLGAGHDGRKDGVMATATPSSGDITFWDLNRGGRVMGVLRSAHNPPSGEGDAIRGGISKVEFLSGQAVIVSSGRDNSLKSWIFDETPFSPIPKILHSRSGHSGPVNCLQFLPSDFDGAEAGNKWIISGGKDRSLWGWSMRRDGQSTELSQGNIRKKAKKIGILAANALAHGPTTTLEDLKAPEITCIAASLNRDGGMGALPGKQEIWQKGRDPKKKLDAEISGMTGWESVVTAHKGDAYARTWFWGRKRAGRWAFPTGDGTDVTTVAISPCGTFALVGSGAGGIDMYNLQSGVHRQRFPSKLTPAQARQLKMQQLRQADDVVQLQSEGNRKYPAGVGKHTKAVTGLVVDAMNKTVVSCSLDGKIKFWDFLTGTLLEQLDWAPMTLPTGCRYHPANNLLAFSCDDLSIRVVDLETKKTIREFWGPKDVINDFCFSNDGRWIIAASRDSVIRVWDLPTSHLIDAIRLEKPCKAVAMSYTGEYLAAALEDSPGVTIWTNKTLYKHVPTRQISEAEISLVAAPTTAGEGNQGLLEAAFEDDKAEEEDSGVVAPTVDQISADLMTLSLVPKSRWQTLLHLDLIKERNKPTEAPKLPEKAPFFLPSTSGAQVPGAKDGAAEAENGSKSRISKFDKARFEETFTSKLRAGAANGNYDDFIEHLKSLSPSSADLELRSLSLGEDDESNELLHFIRALTTRLRARKDYELTQAWMTVFLRLHFDMVMESKTLLKALEEWKAHQEKECNRLDDLVGYCSGVVSFLRSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG08</accession>
    <name>A0A2T4CG08_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_63966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG08"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="220"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="354" mass="38809" checksum="E00B66B3762FEE46" modified="2018-07-18" version="1">MEEAQRLAGIRELDLANYGPVSVVDRVNVVQGLRTSAAFFTFLRANLALSATSPSTPVSSHAPTPYLEPYSHHQFPIPPSPSPLSASTSFSDTRSSASAYASTPLDPIDDVPPLSLEPLLTHDDKVAGLNLIADSIAQMKQRAAQSMVFHPLCITLLFLTWAGIYRWAYEPSTADPSMALLLSCGVTVTYLTAIRYATDGYVNLAENLRWSWLEGSGSVEGDFIIGARYGGALIGVLVLRLEPRFSSLSSGSGRRKNRSRSMSFRGGKGVIRAWTTRLRYRNKGIGRDLLDGAIRIVKDRCGKDAEVGFAREHANSTMLLPAMFNGAFRRDEVRAAKALEKALEEWEASKRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG21</accession>
    <name>A0A2T4CG21_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_195778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG21"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="195" mass="21387" checksum="07DF5FDCB0C4B393" modified="2018-07-18" version="1">MRFARRIESALFGIPYRTRKVIALQRPLTSTGVSFLSPPTPIDVLRYDILIPSIHTSRLSVAKNKSSCWLFMHAARAITTADMTALLNPVSGSPAAPYMKLEHGMMRKRHVVFALNFTPKHDSCFRGKVASGSANCKAFTPYHHRGPRMGGMTGTHPGSTKCCIAETHITYQSKQLVAVASENYSLAPTQAAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGC7</accession>
    <name>A0A2T4CGC7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="9">6.3.4.16</ecNumber>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1348768</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="9"/>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CGC7"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000036">
        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="552"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="1089"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="1346"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB80625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1802" mass="197859" checksum="7623DC03CF9F7FB7" modified="2018-07-18" version="1">MAVQVLQPASASYGTDERLVSLELEDGSTYRGYSFGAEKSIAGELVFQTGMVGYPESVTDPSYRGQILVITFPLVGNYGVPSRETMDELLGDLPAHFESSQIHIAGLVVASYCGEDYSHFLATSSLGTWLKEQGVPAMYGVDTRALTKRIREEGSMLGKMRLASLSSADTFEEIDWVNPNTQNLVAQVSIKEPKLYKPPASVARKHPSGRTIRVLCVDVGMKYNQLRCFLKRGVEVVVCPWDYDLAKAAGEEYDGLFVSNGPGDPAMLDITSKNIAAVMETNKIPIFGICLGHQLMARASGAKTTKMKFGNRGHNIPCTSMVTGKCHITSQNHGFAVDAESLPTGWKELFVNANDGSNEGIMHVEKPYFSVQFHPESTPGPRDTEYLFDVFINTMANCAENPAALQAPVHFPGGTIEENERLHPRVSVKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTVLINPNIATIQTSKGLADKVYFLPVNAEFVRKVIKYERPDAIYVTFGGQTALQVGIQLKDEFESLGVKVLGTPIDTIITTEDRELFARSMDSIGEKCAKSASASSVDEAMHVVKDIGFPVIVRAAYALGGLGSGFANNEQELLDLCHKAFAASPQVLIERSMKGWKEIEYEVVRDAQDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSREYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLGIPLKEIKNSVTKVTCACFEPSLDYVVVKMPRWDLKKFTRVSTQLGSSMKSVGEVMSIGRSFEEAIQKAIRAIDFHNLGFGETKALMSIDDELQTPSDQRLFAIANAMAQGYSVDKIWEMTRIDKWFLRKLKGLSDFSKQMTQFTTADIAQKPNLFLQAKRLGFCDRQLAKFWSSNEIAVRRLRLDAGIQPFVKQIDTVAAEFPAFTNYLYLTYNASEHDVDFTDHGVMVLGSGVYRIGSSVEFDWCSVRAIRTLRATGHKTIMVNYNPETVSTDYDEADKLYFENITLETVLDIYQLESASGVLGAMGGQTPNNIALPLHRAGVKVLGTSPEMIDTAENRYKFSRMLDRIGVDQPTWKELTSFEEAKAFCQNVSYPVLVRPSYVLSGAAMNTVYSEKDLESYLAQAADVSREHPVVITKYIENAKEIEMDAVAKDGVVVGHFVSEHVENAGVHSGDATLILPPQDLERTTIERIEEATRKIGAALNVTGPFNIQFIAKDNDIKVIECNVRASRSFPFVSKTMGVDLIEMATKAIMGQPFQEYPPTDIPPDCVGVKVPQFSFSRLSGADPVLGVEMASTGEVACFGVDKNEAYLKALLSTGFKIPKKNILLSIGSYKDKKEMLPSVQKLQKIGYKLFATAGTADFLQEHGVPVQYLEVLGKEEDKDSEFSLSQHLSKNTIDLYINLPSNNKYRRPANYMSKGYLTRRMAVDYQIPLVTNVKNAKILIEAIARSFDLNVSKRDYQTSHKTVVLPGLVNVAAFVPGLVTPESDDMETVTKASLSAGFSMIRVMPLGLEGAITDGITLRAAQQNSKRGDFCDYNLSVSATSDNDSQISALAGEVGSLFIPFNHLSGNISKVAAVTAHFDAWPTHKVIVTDAKLTDLASILLLASLHNRRIHVTSVTNKDDIRLIALSKAKGLRVSCDVSVYSLYLSTKDYPELDRLLPTPEDQAALWENMAHIDVFSVGSLPYQLAQSLGHKADSSSGIADALPLLLTSVSEGKLTVDDLKEKLYQKPMEIFELHDQVGTSIEVEIDRAYQVQPGNVWSPFEGLALVMASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHD7</accession>
    <name>A0A2T4CHD7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1004657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHD7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16076" checksum="6D6FA1F69012A129" modified="2018-07-18" version="1">MRPSILTCDGATTVRAEHVQVGCRGAPAAPLDARRRCTPHRQTAVCRLLSLMSGSDAAARTHWEATEPQAGSLPHVLHTLALSAKLESPCHPEVPCWTQTEKRANDEIVTSGLIRPPVSTLAALLHAADPMLDPRLVPLPPCPPVELGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHH3</accession>
    <name>A0A2T4CHH3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NIMA interactive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_44546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHH3"/>
    <dbReference type="STRING" id="983965.A0A2T4CHH3"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44325" checksum="175D9E7D0272EA8B" modified="2018-07-18" version="1">MIDAENLRTASLYINNQLLSRGLLRDGQEIDFADCGRRGYFGTADSASRIIGILNDLLIRRDRDAEQRDSLSTAVRTLRAENLKHTSDIVRLTEKCADAQRRSDIAATSEAALKTQLKSAESVVKGLKDELARTKGLVAQLRASCATEMRRRDRQIETLKKQVGEAGRARGTRSSSGVISITVTGDVGNEERRSPAQGGNIEDTDYSLRSESNAFLATLAQNLSEENEALLRIMQQAKDHLREMSGWTGGETQTPEVVKPQGWEEIAAELGAVMDHMRTILTNPSFVPIEEVMVREEEIDRLRKGFVKMESRWEDAVHLMDGWRKRMAKNGRPVGQDDIRMGLHLSPVRVADVEETRAAGRHDLSAVQEESEDEMKDCEGMLRAFLSPSWATPCTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHJ1</accession>
    <name>A0A2T4CHJ1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1366696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHJ1"/>
    <dbReference type="STRING" id="983965.A0A2T4CHJ1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="639" mass="71410" checksum="C0941F85E11A93AC" modified="2018-07-18" version="1">MTLHRPEGYNEALAGSASSPSISGRTLIACQTCASAKTGCDKKIPCTRCLEKNIPCTARYARRASKAAIRAAQAAPSSTKNRTVGLGFDLQRRQKKSFSFEVGKYPETHSQESLQQLRSSADQHDDTFWNTPDPLSHFPGYADHLNTIEHRPESPMAIGFFEYTTTVDLINNDPSMRVPRSHDLYPHDVIDGSREPHLLAELSYLPGLKDLSSLVQTPSPCEDTSGLLGVCRNITIDPSSASSESHLWKRPSLCGARTLAYNWVQIDQELSLFHDTEQSLSTCDLERPLPDPNISWNRRNIIQDSHLYLCDGLYADAKAQEAFEYDFRPTLNQLFKDLTHDTSSGRVPPRHLRLLLHRLQALAHQSRRLVSFANDDSSSVLCEVANSALLETQRLLRAWYRLAMEAQEESAYMPDADTTLGMILYHLICLNLVASFVDIERLAERKSIGMRFWQQSLQHERSIYSRQQAILHCGQALRYLRAVSIDSLPWWWPTAVHRAIMTLWAASILETGPAQNGGAPPVCSPRDFWPRDPMNHTDIESGANLPVATEPSIVAIDNVAPEDPAFGDANWSERHLLALTGQDEGTLVGLTDAMGILQYGISLIHAFPSSVEGEAMVTRLKELGRAWERSNTGQTYYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHJ6</accession>
    <name>A0A2T4CHJ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1417769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHJ6"/>
    <dbReference type="STRING" id="983965.A0A2T4CHJ6"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="7">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="372"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="431" mass="48874" checksum="1CC08F0DF01A375A" modified="2018-07-18" version="1">MSFKGFQKSLVRAPQQFKSKFNIGEHTKDAVYIDAERRFQELEKETKKLHDESKKYFEAINGMLQHQIDFSKAMTEIYKPISGRVSDPDSIKPEGNPEGIRACEEYEAVVQELQETLAPELETIETRVIRPANELLDVIKVIRKTAVKRDHKQLDYDRHRTTLKKLQDKKDRSAKDEKAMWKAEGDCEQATQDFEYYNNLLKEELPKLFQLEQEFIKPLFQSFYYMQLNIFYTLHERMQRCDIGYFDLTKDIEEAFIEKRGDIQERAEALSIVRFKTTGQRRPPPKALGRPALESSKPQGLLTAGPTTSEKTSPKLGSFQTEQHADAGEASAPPPYSAATKPGAGALSTLVAGKAKPPPPPKPKPSRLSGAPPPETVTALYDYAAQAEGDLSFRAGDVIEIIQRTQNENEWWTGKVNGKTGQFPGNYVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHU6</accession>
    <name>A0A2T4CHU6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1434991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHU6"/>
    <dbReference type="STRING" id="983965.A0A2T4CHU6"/>
    <dbReference type="OrthoDB" id="4733706at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015784361" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="66919" checksum="028899F8F3D4AF47" modified="2018-07-18" version="1">MAFNLLLFLTCLIVLPFHVASSDLVVRNLPGKSSDETVHEVRRRLANRVKRAGTDVLFDNSTSFSLGLDGTTIFKYPFEDASGDGISASISIICTKCYIKGRASAKLTASGPFNITSAVDTAKDSFEATWHNLTDYAQNVTRTILDEVASDIKHLDFSGLIDDVKDIDPPNLDMNLNLLFPEYDVGVNLTDLEIYMELDTVLSAGITYTFNIYQSETIVGIALGDELLLGAVFSIDLIFSVDSKLDISSGFHVHFDNVLTHITLFGKEASKIDLLAFLPVKIRYGNVLLKAILRVGARIGIAFETFIDGISVDAVGLKALKVGAGVEARVYANIAEFVTNITLAEVDLPSKRDDDDRDDDDDSKDNNCLLSMAQAFTFGIGAAAGATVELIGNTWGPTPETEIPLFYTTLAQVCAPTSTSSATTETTTTSHPSSSTPKQKRAQAPSITRTITSETQVATICASVGLINCPASLQTVTRNVVTKTLTSTITSGVPVVWSTATAAAASALHTVAFKDDAVTMTSSSGKPKSYTPPPPPQTSTSSPSGSSSPGDDASAKGKSGSHRVSNAVIIGVSVGLGVPALLAAVGAFIYFFRRNRRASSSLVSAEPATTVVTKAQPVVATYAPVRPDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHW6</accession>
    <name>A0A2T4CHW6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1008695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHW6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16515" checksum="2E9B9F71577067B5" modified="2018-07-18" version="1">MFPANHRRGRLRQCWERISGCLGLKYGRSRLFFCGEKIKDKERERERDGGGKRGNIEREKTTLNPCRHSISTQMHASDRSVPCCCNALFSSVCATCSIRSPALTRSFLKCINELMNHHRSMIQSLNPSIDDPSRPGPSPPPAAGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHX9</accession>
    <name>A0A2T4CHX9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1459437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHX9"/>
    <dbReference type="STRING" id="983965.A0A2T4CHX9"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="422"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="580" mass="62628" checksum="9E5FBD829487C37E" modified="2018-07-18" version="1">MPSRNRQARGPITYTNPIKRVPLISRYEYGLNAKPFSAPLRPCISNSALRSPASAEASDFCPSFFSASSSTKPSTIALPDSSRSALLSPTPTPIPTSTSTSTSGADAIPSFPASAVVPAAAPFPPFPRLPSASASASASASASASAASASAFHQPAHPGPPQAPHNPALHKRNQHSIFRTLATSGASPTRLQRLSSARLWNPTNSTPRSPSNSHKRRPSSPIETPVRLQHPGLDQSTNTADPNVTGAGDYPLLTLTEHRQARHSSSTPISFQFDLSGTDNKRVSLPSSVRASYDERRSQTLSPTRFDRQSRTSGDFTSESPPLTKTPKADKGKGIMLPENDESGQSYARDLERGPDVMDHRRFSNISIGDGIGSAISSSNSSIMGEEVQPDLGESWGPQHPCFPHLNPHVPSDSAEYAKTRIIRIRRDWLLQGDLAPTFSNLYPEILDPAGIPEPEFRRIIDKLNKELIPAFDPYNPRNVVDAFLGLVTGWLWDDFGMTGIKSRLNNLEAWIDNWNREKEKTTPSEEGILPPKLISLRRTGYMTLDIQIPDPEIAPAPSSTGAAESIAALPMEPAPVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI24</accession>
    <name>A0A2T4CI24_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1316760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI24"/>
    <dbReference type="STRING" id="983965.A0A2T4CI24"/>
    <dbReference type="OrthoDB" id="4860873at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="26251" checksum="A8C6417FF9D1DE66" modified="2018-07-18" version="1" fragment="single">MAVVERILRWPGVDLDHGDVDGHTAVDWAARKGHTEIVSLLLERPELTVDWNTVDRRVNPLCLAVEYGYEETARRILERHAGRISVNSRTAIGRTPLCHAILRGWDALVALILKHPEVDVNQPVDFAATALHLAAVYLADQTMLRLLLADPRVEVNIANGYGASPLVNAVKKGYEFAVRLLLERPDILPDMKDGVGMTALAWATHLGRLGVVEMLLDRQDVDPNARDDDGVTPLSIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIV3</accession>
    <name>A0A2T4CIV3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1418148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIV3"/>
    <dbReference type="STRING" id="983965.A0A2T4CIV3"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="13541" checksum="B559443C9912CDED" modified="2018-07-18" version="1">MSSSQQVSAKKQQDLQATYSNYKNTLQQIASKIGDIEQEAEEHKLVLETLEPLSGDRKCFRLINGVLVERTVKDVVPALKTNQEGLKKVLDDLVKQYKNKQDELDKWKKKNNVQVVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIX6</accession>
    <name>A0A2T4CIX6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIX6"/>
    <dbReference type="STRING" id="983965.A0A2T4CIX6"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="37469" checksum="1022A6C982632567" modified="2018-07-18" version="1">MSAAADDDEDDYMNMTFQDTPPTTETSVQRAERLKRESRARGIIKSKAQLAREEAAAREKALATSLLEDARAKKSKGLAMMAKMGFKGGGLGKKTEDGQGSGKTEPIKISMKEDRGGIGMESEKKRKLQEAAEERDVKAVKVDPLEYRERMRAEREDARLESQLRAAQRTAERLDEEMSGTELSQNPDPPPSASKEEASKSKPKTGPSRPLKSVPVLYRGLVRHREEKERERRLRRELDESLSRLPTYENSDEDDDDKMAMGKDVTFALADDLDEEDEELEEFEALDLKTRLARLVIYLREKHRYCFWCKMAYPDAEMDGCPGVTEEDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIX8</accession>
    <name>A0A2T4CIX8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIX8"/>
    <dbReference type="STRING" id="983965.A0A2T4CIX8"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="240" mass="26312" checksum="864A88E1E9372D14" modified="2018-07-18" version="1">MEPLSTLPQLSSSTGKREYTLQHLQVKHSSRKNGCANRREQRVGEEIGVAPEVILETSHGRRSIDILKILAPEKANWEYVTKMEGELPKRYADDVVEIPGARSLLSSIIAQSFPWAIVTSGTQPLVRGWLERLSLGTPEHLVSAESVENGKPDPTCYRIGLEKLGLQDKAGEVLVLEDSPAGIKAGKAAGCKVLGLVTSHTVEQVVAAEPDWVVKDLESVRVVRQEDGKMTLELSNALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK30</accession>
    <name>A0A2T4CK30_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_95626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK30"/>
    <dbReference type="STRING" id="983965.A0A2T4CK30"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="140"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="322"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="471" mass="51032" checksum="C40A5FDEED8023EC" modified="2018-07-18" version="1">MMGSVFYKNLPTDRKYHRIQSIGENTGAVAGVTPPVPTVTAPVGSLYGSTGLQGGVAPIPDTSKESAEVKKFEKVNGQDADASLGVYLDLDSVDEPQPIRGAFGGTDAGPRTFEYEKLNPDLFAAPGTDSGAVPNAVWPLGLSHNRPGASGRAGWARQQNTAVLPIAKDMAGVDMKLEPNAYRELHWHTAGEWSLILKGCVRVAAINDESQSFVDDLCEGDVWFFPAGVPHSIQAFENGAEFLLVFDQGDFDENGTFLITEMFARTPRSVLSKNFRAPVDSFKNLPSNQLYIFNGTPQPKDISKQNITAPGGFLSGPNGYTYHWSQQKAYEVPGGSVKILDPTTFPIAAKFSAALVTIQPGAMRELHWHTTSDEWDYFIQGSGRATIYAAPSAANTFDFTAGDVGYIPQADAHYIENTGTEDLIFLEVLQAPKFSDISVAQWLALTPEQTVIDHLNISAEVLEALPKEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP34</accession>
    <name>A0A2T4BP34_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1345117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679249">
        <property type="protein sequence ID" value="PTB71046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP34"/>
    <dbReference type="STRING" id="983965.A0A2T4BP34"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9739" checksum="BC78AF8C3A90F16A" modified="2018-07-18" version="1" fragment="single">TRQVKAIEAFEVEAVKNAEATKQAVDLELKDLAATLKNIEEARPFDELTVDEVAAAEKSIDEKTAELVSKGRWMVPGYKEKFGDLAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPM0</accession>
    <name>A0A2T4BPM0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1386843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPM0"/>
    <dbReference type="STRING" id="983965.A0A2T4BPM0"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="825"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1229" mass="138545" checksum="5ED78A5654899822" modified="2018-07-18" version="1">MPSQKLPFHVAIVGGGIGGLCAALSIHHHCPKDGSVVIDVYEQAPEYKEIGAGLGIGVNAAKLLHRIGVGEDLNKISGHRNGIWISFRRYDTGSEIVTVPVDDQQEIRQSPVHRAEFLTLLFDHVKKRNAATLHVNKKCIELKDQGNFVELCFADGSTTTADLVVGCDGIHSNIRSQFRSDNPKYSGRMCYRGLVPIKDLESWWPFPSYSISWLGPDKHFLAFPISRNTILNIVAFVYSDDDRTKESWTATGHRSEVQKEFESFDATVRKTISFMNEHPSKWILNDRDLLDQWVYGNGKIVLMGDAAHAMLPHQGAGAGQAIEDGYILGRAISDYLSTSSESDTQSLEKWMQLYQDVRLPRAQKAQETARQAGQVYEMQTPEMKGKSYEDCLPLVRDSLKDRMQWIWAGDIEAEYEAKRQRLMDQEAGANCRDSSGSKIDSVTERAVLARKPRCWGGQVGACWRPVRREKWWWQDEAWSRHVPALVFHGPIQFFTGQLCQSAHRVPFAPRTTSTVTGIEEKPRQTSSASDHKEGPRKRRRATVACRSCRQRKTKCDHIVPAQASDEMLRGMTKSAQVYIRSLERRVRNFEDVQRDANKYHQNQQQPQPAAQTISPVPSTSQYEATRMTPIQRPTRPSTWSSAHNQQLRPNVLPTTPDIFLSGKAGESFTQLILNAMNHPSVKLDSQSFSSPRDSSVDLRSSENLFSPPVNTREYLQVYFDFHHELTPIFHVPSIMAEFEQILSTRICSGNSHHVYILAILNMICALAAAHSRQRHGDSDTMSRKYYNTAMQLMQPNILSDWKIEKVQALLLGARYLQSSSYSDECWTVLGLAIRFAYDLELHRPPDPEQFDCIEQEVRKRVWYACFGLDKLFSMMYGRPAATSTATFSTPLPEDLDDDCIRPHRLLFPSVQTTSSMSFFLQVSKLYRILESTTLLGDQPTLADLVRLDEEFESWHAEIPNRLRIRDADLRGDERALILALRANMVCILIHRQSLVSGLSALSSIPSSTAVPAAKGWEGGRLRTSILQRSRQICVSTAEETVRLVAERHERTKNAMGPSWFNLYYLFTSILIIVSHVVDPDFQDDRTALMHLDQAVNMIRQMSVNHLCAQRAYAFLQQLLGLLDQTMPEDRRRSLDRCSTPPPAMTGSNRGTAEATMYSNCPTMGADEAMEDGAVDLWSLWDTTQDLTMDLGSQLELHSSLGSSTWSWGVDNPGAESLMQTPPALGGIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPP3</accession>
    <name>A0A2T4BPP3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1406648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPP3"/>
    <dbReference type="STRING" id="983965.A0A2T4BPP3"/>
    <dbReference type="OrthoDB" id="4436466at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="224" mass="24957" checksum="B93B21A9A8198949" modified="2018-07-18" version="1">MGIIRKASLGVTLGTAAALGYVRLSTSIIAPIPLSDALYSSNSFKKYNLHRNPATNDVCVKTIPLNRIRPELLQKEGDLALEFCRAVWKGWGYSIQRRYLHRKYFGTDTSSQLWTPEQIAASNFEPGTIVTDHFEVVERTPTEITIRCGDSPRNQGPRPSDGLFAIGATIDKDAQVARLTLKSCFFPSDRKAEGDKGPMPGWVESLHQWYSRILMVSAARALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPY0</accession>
    <name>A0A2T4BPY0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1406583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPY0"/>
    <dbReference type="STRING" id="983965.A0A2T4BPY0"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="16734" checksum="6455C75084668A95" modified="2018-07-18" version="1">MAAALPNISSDLIWEVVRSNNSFLHKTGAAKNGGVQFSRDPLNLKNVHSRKYAGFVNEKAVGVLPNEKGGVVVLTKKPAAVAQPSKAVVKTTIGGNRSTRKTYKAVANQVAKTGYRPDLRAAAVERVSAIRHSQLPVKADPEPKLRGKKAKAAAAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQJ3</accession>
    <name>A0A2T4BQJ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1406346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQJ3"/>
    <dbReference type="OrthoDB" id="4900125at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="194" mass="22033" checksum="881D75EC9C23A56C" modified="2018-07-18" version="1">MNNNTPPHLAAMPTTSEESVRTQAIHDGISALRNDLSEIKQQFNQLSNSLIQPASSEPETQSSSLPDLPSQSPSLYARRIGLANQTEVETAYQRDPADFIVQVKATLHDSLTPFHWDDAESIGRMKRFFSYAGISLDLLKTGDVQDDNFASVARSDLIVRGDMVARHLRAHFWIHERFVLYWTLLEICRVYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR07</accession>
    <name>A0A2T4BR07_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1473347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR07"/>
    <dbReference type="STRING" id="983965.A0A2T4BR07"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="619" mass="70357" checksum="8C92D47AD794D3B0" modified="2018-07-18" version="1">MPNASQMASRHEVTPTVPTVQASPRNGEPTTKQPRRRACNECRQQKLRCDLVANDGAPSTCSRCQRLSLSCKVDNDFRRTRKRRKSFELENEVRELRRQLATHEASSAALEWPIIPPAEARVSEVAVSSVSGASGPSPDPRESSRVPGLTTQPVIDQPQEPRRSIITIPRARKLGNVELSVEEIDELYLIYMLHYHPYLPFLDPNTSLHEYYESSPLLFWSVIAIAARRLQSHPTLLAKLARSVTDLLWKTLRSIPYSLRVVQSLVILCTWPFPTSSSTADPTYMLAGIMVQMGTQMGLHRALNAEDFVKVPLHLNVYEYSEWVKTWEACNIVAQSVSVGCGLPATIQMHDWSLTVAPESMASPHDISLKWHLRIEQFRYRVSQALTSNALDPAGFMSARERLSLYRLLNASLVDLEREAINMTPITRYYLAAARLHLHSFHLFDDSSVDGYSDRIVALYYTAYSLIEQCLEMENQESGFFHYCPFFCYQVFVSAAFIILKVMMNGYFEQLLDVEAGKRLLDAAISSLRKMSVANNDLPGRLSDVIGFFCSLPDPRVISGESIDDLRLRVRNRLSMSIVYDSLWEWRKHFQSDDDDRIEGSEETQDKLTIAIANYAHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRB4</accession>
    <name>A0A2T4BRB4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparaginase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1406148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRB4"/>
    <dbReference type="STRING" id="983965.A0A2T4BRB4"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015774897" evidence="4">
        <location>
            <begin position="24"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="244"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="362" mass="38180" checksum="550F6F336AC5B1E8" modified="2018-07-18" version="1">MPPHMSLSTITTALTLLLPQTQAILTPPPLIINTWSGPFTAATDAAFLALTSSPQSPSLALDAAQAGCQTCQANQCDTTVGFGGSPDESCETTLDALIMDGQTLNAGAVANLRRVKDAVGVARHVLDYTRHTLLAGEQATQFALENGFAEESLSTEDSLRVCHEWRSNHCQPNYRSNVLPNPLSSCGPYSPNSNITSSESDIPPKSTEINDPSHDTLSLIALSPTGPLATCTTTNGASHKIPGRVGDGPIPGSGSYADSQAGACAATGDGDLMMRLLPCYQAVESLRRGMTPLEAARDAVRRIIARFPGARTGIVVVDLKGEHAGAGSGWEFTYSYRGGEMERAEVVVVEALDKVVDERLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSH0</accession>
    <name>A0A2T4BSH0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1394889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSH0"/>
    <dbReference type="STRING" id="983965.A0A2T4BSH0"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34683" checksum="D76DD726554AF581" modified="2018-07-18" version="1">MEKYSQFRDRATGIAPFLTVSSASSPLSTLTHALLFLVRLPFFLTYALGYFLLFHPLPLPVFARKIALWGLMAIPGIWWIDLQLDGVKRGTLSEQPRERVPHPGSVIAANFTSPIDAVYLAAVFDPVFTVSYPGERKVRKIGLLSAIRMALAPVNIGPAPEGANLIDLKDLIEQYPNRVIAVFPECGTTNGKAILPLSPSILQTPPDVHIFPVSLRYTPSEVTTPLPGQWIRFLWTLLSRPTTCIRVRIAEGTTNKAASSTGSSELTYRGGSGGGVSSEEQKLLDWIGEALARLSRVKRVGLTMKDKAAFVKAWSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSM2</accession>
    <name>A0A2T4BSM2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSM2"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="119" mass="13275" checksum="D123E5DAE22718FC" modified="2018-07-18" version="1">MPVSIDSSRPIMAPSARTSYRFSSYSMAAPSVAMSVQTNDSQHAEIREIATGLDRMENKALTSQRVTLSEEKYEKMSKLALGAKLERALDRRMSGQDAVMRPRRKTTSAVEKTFSEKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSQ2</accession>
    <name>A0A2T4BSQ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1342156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="8"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSQ2"/>
    <dbReference type="STRING" id="983965.A0A2T4BSQ2"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000128">
        <property type="entry name" value="Endo-1,6-beta-D-glucanase neg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015653927" description="glucan endo-1,6-beta-glucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="11">
        <location>
            <begin position="64"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="12">
        <location>
            <begin position="404"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB72328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="476" mass="51304" checksum="D919A9750BA4E5AF" modified="2018-07-18" version="1">MLFISVLTTIAAVGGVNAASSFASTADGKNQFTAVQAPVLNAANPGIDNWKFTIKEKTGRKQTVKGFGAAVTDATVAAFNKLSASARSQLLNDIMTPAGLNFNLLRHTVASSDLSADPAYTYDDAGGKVDTGLNSFGLGDRGNAMISMLADMRRLQSNLTILGSPWSPPGWMKVKGSLIGGGTANNKLNHAYEDAYAQYFVKYLKAYESGGAHIDAITLQNEPLNNKDDMPTMLIQQDESGALIRDKVGPALRNAGLSTQIWAWDHNQDVYSYPQTVMNMASQYVQAAAWHCYAGNNPDNWTPLTKFHNEFPGKDQYMTECWTAVGTTDWVHSSSFNMFPLQNWANGVIAWTLGSFTGGGPALSGGGNCHQCTGLVTVSPDGSGYKKEIDYYMMGQFSRYIPKGAVVVDGTGSYLFADNTGMEAVGTINPDGTRTVVIQNRYSHDIWVQVGTESESQTWNARVPGSSVTTWILPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSU4</accession>
    <name>A0A2T4BSU4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1442060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSU4"/>
    <dbReference type="STRING" id="983965.A0A2T4BSU4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="514" mass="57325" checksum="222F7AEA1C6FE538" modified="2018-07-18" version="1">MTQKRIAKPKVAVCGLGIAGISACKNLTETGFDVTGFDASDAIGGLWHYSEDERTSCLYNTRALVRRRMVGDSDVPLEPGEIQAFLESYARHFELESRLRLKTKVSAVHRVGDKWHLQLTKWNGESEEQAYDRLVLCTGLNHSPKTVHFEGIDGFKGQVFNTHTYKRQDEFQKPETLQGKRVLIVGLGATATDIARGLVGIAKSIAISHRNGCLMLPFSKANDFCFPPLRMQRGNTKKPVMEQAQILHKAFLDMQDEAYDVKPEWGLGNPPPMPYKLPIIGDGFYEHLVSGAVTLVPGLKRIHESRVELSDGSFLEVDVIIFSVGYTKSYSLVGPWDPSRNMPQAWKDAPGSVGRPLPRLYQGIFSLDFPDSLAYLEHVGSTLSATMNGDMASMALAQVWVGNSKLPSDAEMSRNADKQNQMAIFLAGKGEIYDPAMVDRGEWTLWVDKAAGLGIQDRIGNGWKSWRLMLTDYRLYKTLLDGTFVPQVYRLFDEGKRKPWVGARESFLKANGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSW6</accession>
    <name>A0A2T4BSW6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retinoic acid induced 16-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1472775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSW6"/>
    <dbReference type="STRING" id="983965.A0A2T4BSW6"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113010" checksum="75EB8DFBD0AD0962" modified="2018-07-18" version="1">MDFWSRLLSPLSSGSSRQDQAKDPAKRLHRFEKEYAGLLSIWRKSTNLSQDIDAAETVEIRLQELTNILSDESRRPLPHPCIQYASIKQIYVPIGKIATSSYNEWIIKEAVLFFATLIESEEEAFVENHTFSASLTNLLVRITGVNSARLGLDTESRVVELAFNITTKIRLDPDILPAWFKTQQDVNRPSDRAASVRDKFAGRTKRADFPLFYILMDYIHHEGKVGDFARTGLLYIIEAASSSESLEQWIVESDLSTLMATGLGALYSQLSRKLVIDHLPNNLPPILALSDYEHPTSNYEIVSSCSAEFQSHLETFLSHLLFWQDVLNHCKSVEVKSTLLEHFQVIFLQQLLYPSLLESSDIDGGSSVAVLTYLRRIIESLDHPDMINLILHYLLALPDAVISHSPPSETAISAARQRKSMDLATMMAEKPDTTATPLLFNLVDLILACLRSRNQQTIYVTLQLVSAIVKRHHRYAVLTLLRTDSFPSNNINRTVGAHEQEIEYLMALAESIGGRDDFNETYESILKDTMARLESHPCSLRLVAPRLSQHNHKLPTIPDSLPGAPKDVREHTLRHDDLLLNSILDLMENFFMNPVETNLSVTDTIVDMAICGYMSIEGWLARNPKSYIYEEDEQQKAEAKKETKSQQEEGEGEEATETGTRTGADAEAETGNQSLADELNSQDDRFSEGGFSTFSNNTEADRLESMEKCRRRPKWTQESLPRILIVLKRLCDQVEAFRQTVPRFDELLQQRREAFQTADSILDNPPAPVQQRTPERPSSSLDDMIRSVSPSRPSGLEGFAQRLLSELGSPGRSVTTRERKNSTRARSGSSTPGYNVSDLLSPSPMPNTSKPLPDPNRGPLSRGLSPASAQSEASRQHRGSRQGSVVAQPADFAAVDQSILARRVALPTEPAKPFPTESETKRQDAPETALSGEALASLDGYDSSADRSEVPTEPTVVTETTDNAEPTSPAQEENMVSVSHVITNVLIFQAFLMELASLMQVRAGLFNEVRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT48</accession>
    <name>A0A2T4BT48_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_347930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT48"/>
    <dbReference type="STRING" id="983965.A0A2T4BT48"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23830" checksum="327AF9659622D8D7" modified="2018-07-18" version="1">MKASSILPVVHPLPPLCITQLRRRRQTLQLNAMEPKLHEIDPNGDTLLMLRNPNAPFLVHAPSTSPPKKRIKLKSTCGKPEVRMRLSSKHLALASVYFQKSMDSFKETTAKGRYSYTINAQDYDEEALLILMNLLHGNTLEVPSSNLAKGYPKGRDALYNLCISWVFQDAKSFLLSTIGIIRTSDGSLNDIGLPLPQDAITKSKCNTYFEDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTL0</accession>
    <name>A0A2T4BTL0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1465328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTL0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTL0"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="307" mass="33910" checksum="CBEAEE2D11B9CCF8" modified="2018-07-18" version="1">MSNVIAVAGGTGSLGRTIVDELKTSPLYSVIVLARKAPEQQDEKAPVIPVDYSNVADTAQKLAENNVEVIISTISVMDPVAGEAQVNLVKAASQSGTVKRFISSEWGAPHTPASPIYQIREDTIIELRKTNLEWTRVANGYFMDYYGQPHIKTYLHPLSFVIDVPNKIAAIPGTGNEVLAFTYTQDVAKFTVASLSLPKWEEATYVYGERSTFNKVLALAEEARGTKFDVTYDPVEKLSKGEITELPSHKEIYPIFPKAMFQGLFALFSLWIIEGRLDVPEDKSLNAKFPEIQTTKLSEIVGAWKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTN0</accession>
    <name>A0A2T4BTN0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1079321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BTN0"/>
    <dbReference type="OrthoDB" id="4893298at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="301"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="922"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1350" mass="152252" checksum="410D067D043479BC" modified="2018-07-18" version="1">MRLLSFNGSQLTFSKDLVSDRPPYAILSHTWGNDDDEVTFSDVIAGKGSDKSGYRKIQFCARQAASDGLSFFWIDTCCIDKSNSTELQREINSMFRFYRDAAKCYVYLTDVTKQRDLGEPGPSSWETCFRASRWFTRGWTLQELLAPLDVGFYSSEGIYLGSKKALEQEIHEITRIPINVLRGGQLSQVPIAERMSWSEGRSTKYPEDKAYSLLGIFGVYIPLIYGEGAENAFARLRRAISDHDAIKDYHPKETRDRLLGWLPYIDQQRFYWEAQSVKKSDAGTGNWFLTWPLYEWTRQKSLLWLNGKAGSGKTVMTSSIIEHLAKLRTGMLAYYYFSFQNRESQNLRNLTCALLVQVLKSLSLPHPTNPDVFFIPGAFRNMYDAHFPSRSPSMEELESTLVDIVGLSETTYIVIDALDECDSQMVWSDILTFLSNLINKVGTNLYILVTSRQEVDIETKIAQLPVATTSVALRAREVDRDIINHLHAVLKEDSFTTWSDALKKKVTDHLVQHADGVFRWADLQLQGLRGKSREVDVNRALKRLPRDLGETYSRMLQRIDEDNYRLEAMAVLRWLACASRPLSLAELAELAVFDVEDSDQANLPPSSGEYRVFVLRENRFNSASEVLHILSGLVITTRSDGSGDAGAESQDAHRTILSFSHFSVKEYLQSTHVMPPMFRLVLNECHWFVLKCCFAYMFAYDMEKNAPSEKYDLLLYACFSTWYHVKELNILNAEDVHAATFHSVTAPSLERPGYATAVASEKIFHECKPRNFNLVIDFLEKFNMMEWQPDCLTTFMCFHEDMGPRDAQSVEHLLEATVVGNVRHARLLLDGNVSAPADILTTFLKGRSGMRIHFRRANMGGPVADLSLTVGSAVDAVKATETETHNRPRIPRSGRTSIEGGMAMWNLLQSQPGVNLNAQDREGRTPLLMAAMRGDEELFDHLFTQDGVDIGAKECHGWDLLTCALLGRNTNIIKTILDSGRFELDHEDLYGRTTLEWSVHLGLYMLLASATHVSQVSGQSFKVRQMPFNPIKEVWARKRVWYCAFSRGGSRVALCLSSDEVRVYDLEEDQFQSTLRHEGAVTHAAWSPDDSMILTLGLAGATRLWNSHTGKLIKDFSLQHVGGYRCHWLPDGASVIITSRSETMGIVSMTISDGHYHSWLAEEQHLRVHCSALSKDAKWLVALASLSWRLLIYEVEHEKLTASIPTRERPTWVSISDNLSLIVVGYMDGGFETRLLPSGEVVWSRPGISRSDFLLQGSAGGADDAFLLRPEENGYISAWDLRSGTFVGLDIGHHPSRTNAATWNPANPSMFASGGDDGWCRIWSCESTSPDDREQRDGTLGHPVVEAVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU33</accession>
    <name>A0A2T4BU33_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1363085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU33"/>
    <dbReference type="STRING" id="983965.A0A2T4BU33"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22086" checksum="7DCC46F5C6819F96" modified="2018-07-18" version="1">MLDSKVAEATFQATLLNGLSGVCAQGITAYRNKSFDEVEIESILRFIVYSVLVTPPNYKWQEFLERKFPSRTPVHEPSAASSSPPEKQAQQGTQVVPVKDRLNLTNTAAKFVLDQLFGAPLNTLAFLYLMGGMTFQSQAQIWSNIQRDFWPMLIAGYRVWPIIGLLNLSVVPFDYRQLVGSTAGLFWGIFLSLNKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU54</accession>
    <name>A0A2T4BU54_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1394600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU54"/>
    <dbReference type="STRING" id="983965.A0A2T4BU54"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33322" checksum="415BD94E9501EA52" modified="2018-07-18" version="1">MSQHQNAEAKTDRVVPMRVIVCGLQRTGTLSMRVALTQLGFSDCYHMHNLLVSPETECPQWVRLIEAHYGGKGTITKADFDRVLGRSQACVDVPAALFGVELAAMYPDAKVVILNRDPESWYYSCLESVITAAQPASPWVRLGMLFCFVFDPATRAFARFGRAMSRLAFRYDHRTEKDKAIAWYTGMYERFRDEIPEARRIEYRIQDGWDPLCAFLDVPVPMVRDGETGRELEMPFPHVNDRETFRKDSEGRRARAMKRARENLLMGVGRLAVVAALGYAGYALWKMRLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUB1</accession>
    <name>A0A2T4BUB1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1086605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUB1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="15234" checksum="4C587AE3DCB9122B" modified="2018-07-18" version="1">MVESRQDVNEYASLQSQASSTKRFLGIKSSSFMLSHIIHFKCSYHVLKALPMHCITPTAPARAASNPLVEAVFSQPVNQPLRTIRSFQISQRQIFSSVAEERAKVNRIPDPVSLYVVITISVNMSAPCVYCLLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUG8</accession>
    <name>A0A2T4BUG8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1404687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUG8"/>
    <dbReference type="STRING" id="983965.A0A2T4BUG8"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="368"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="528" mass="56637" checksum="DBF56BDB0AC866E0" modified="2018-07-18" version="1">MAATSNMHNLTTLIKRLEAATSRLEDIASSTELPKDVPGLGKPATPESEPAAAPPPPALEEPQEALPESIEDFDNFLNTTLDKYVKLSNQLGGAVSQQAAEVLRGFREQRKFLLIASKAAKPSTSGSSLVVYQNLLKPITEALMAATEIKENNRPDPMYSNLSAVADGIMVLGWVTIDHRPYNHVEESLSAAQFFGNRVLKEQKDNDPRQVEWVQAFYQIFHDLGDYIKQHHPQGVAWNPRGEPAEEVAKSLDSSKDTQRPAAIAGPSAGGAPPPPPPPPPPGPAPVLDIGSDSAKASGGAPAGGFGAVFSELNRGEDVTKGLRKVDRSEMTHKNPSLRAGSTVSDGARAKSPVPGKKPKPESMRAKKPARKVLEANKWTVENFEKEAQPVEIEASITHSVLISRCNNTTVIIKGKANQVTVENSTRLSLVVDSLVSTVDVVKANNFALQVLGAVPTVMLDQVDSAQVYLSKESTATKLFTSKSDGINLNILAGPDDDYKEVPLPSQICSYFSEEKGELVSEIVAHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUX9</accession>
    <name>A0A2T4BUX9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1297330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUX9"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="218" mass="23449" checksum="03B7002D10254231" modified="2018-07-18" version="1" fragment="single">APQGTSAQKANVNLCGVCGSNPGKYKCSRCRLPYCSVPCSKAHQQNHPPDAPKEEPKPTSQSSSEPPAASANAPPQAAIDPTNPFSVLATSDKLQLLFKKYPNLPNQLLEIHAATQPPSDGPDAAARAIPASLREGLSVNTGRNAWNHDIGIKNGKAALRRARKADGEDGEAIREYTELIVHIMNETEDKNSAAAYVQRQLAEQDAALIERLLAEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV67</accession>
    <name>A0A2T4BV67_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_143692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV67"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23182" checksum="C1A313CD7CA3D1FA" modified="2018-07-18" version="1">MSLCMRRGTGQINQLDATRTIPSRGVVAAGSRTPYFPPFSTQVVSLSGPLCSRTPPSPPFPLQRVSRRSVAACLPFGSAGYQQLGSLPFGGAVCNVLLMIVLVLVRVCFVLVAAKSSLAPFFVHFDCTMPVDPRSSFVIWKFNRRYREPNGRVEVQRTEALGREPTGLETGMPKTQAGGSPTPSPKRLFDSAFAVPVRKATYSAFSRVIISGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVD0</accession>
    <name>A0A2T4BVD0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1076771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVD0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="196" mass="21491" checksum="7042DD3B5969AC69" modified="2018-07-18" version="1">MLARPSPHRPGGCAALPLPSSIHLSNSTSHFAPAPDPDRWTPRSPSCSVGQTSRDAVALILAHSSGARWSKLTAVAVFHSELLFIGLRSSLARRFAAPLIGSLPYCENSSPVEHCLAGFPEASRESLAPLIDWETRSAQSTRLFRLESFLLAEEALMPILSSSNQDCWYRPEAGPCHIAKTWSDRSNLFHRSPCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW48</accession>
    <name>A0A2T4BW48_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_21719</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW48"/>
    <dbReference type="STRING" id="983965.A0A2T4BW48"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="381"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB73510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="582" mass="60804" checksum="026C54CE1BC2C4AF" modified="2018-07-18" version="1">MSSKHFVNEPLALVNAALRSATYTNPSVAFDAAQKTVFLRDAATQPTIALISGGGSGHEPSFAGFVGKGFLTAAVAGSVFASPSAEQVFRAIRLVGAEQPRRGVLVLIMNYTGDMLHFGMAVEKARAEGIKTELLVVGDDVGVGRKRGGRIGRRGLAGTVLVQKIAAAAAAQGHSLEQVSQIATLASENLATVGASLAHVHVPGRELIQDELGDEIEIGMGIHNEEGFARVKATLKGLVETMLKQLLDQSDTDRAYINVKSGDEVVVMVNNLGGISPLELGAITTEVIDQLDASYQIKPARLLSGTYMTSLNGLGFSITILKAADKAILPLIDAPADAAGWSPAVHPENWARGVDTTKSESKEDAPIHDDSAPSNLELDAGFTIAKLQSALKSLIAAEHEITKFDTIVGDGDCGLCLKTGAEAVLKHLEGISSSGNLDIVHFVRTIAQVIESNMDGTSGALYAIFVNALASGLQGQSSSQKTAVTAQTWAIALQAAVKSLARYTPARPGDRTVVDALVPFVDTLAETLDVGRAVDAARIGSDATKGMEASLGRSVYVNAEGWSECPDPGAHGLVKLLEGFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW83</accession>
    <name>A0A2T4BW83_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1339276</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW83"/>
    <dbReference type="STRING" id="983965.A0A2T4BW83"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="452"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB73581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="731" mass="80249" checksum="01597ACF7CEFCCD6" modified="2018-07-18" version="1">MMSWWSTSANTALDEQIDKATSSSLEDIALNLEISDVIRSKTVAPKEAMRSLKRRIGNRNPNTQLSALNLTDTCVKNGGSHFLTEIASREFMDNLTSLLQAVGPVAVNAEVKSKILELIQSWAGATEGRYELSYIGEVYKRLQREGYQFPPRVTVASSMIDSSAPPEWIDSDVCMRCRTPFTFTNRKHHCRNCGNCFDQQCSSKSLPLPHLGILTPVRVDDGCYAKLTNKGFKEPIPSLDRTPTYPHKTRSTSAMQPRNARVDDGFDEDLKKALAMSLEEVNNASRGRVQPPTTNGPKTTGGDAAATKQFEEEDEDLKAAIAASLADMEEQKKRHAAALKEQTSGPAASSSTTFTLPKNDYELTPVEAENINLFATLVDRLQTQPPGTILREPQIQELYDSIGSLRPKLARTYGETMSKHDTLLDLHAKLSTVVRYYDRMLEDRLSKAYSQQSLGGYNLPPPRQSSGPYPSIPSHAPSNSIGAENFYTGQQPSYGPPGQQLYQMPSQHAMPQSPYPPYAGMPGPDANPGPYAPQQQIQSPDGWNNRAPSAPEPFQQQPQETSEDPRQYPQQVAASPSTDPNASYYFNTAQPLQAAPTGPSAPGSAPDGSQSPYPNLNQSPMPYHRGSVSAHTQATPLQTPAQPSQPPNAPHMPTHSQASSAPTPPQPFQQDIPQGSPYQVAMPQQQQQQQQQPPVPPPEWAGYSQYSMPSVPQQEPVHQQQPVQEEALIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWL9</accession>
    <name>A0A2T4BWL9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1360467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWL9"/>
    <dbReference type="STRING" id="983965.A0A2T4BWL9"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="12">
        <location>
            <begin position="182"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB73711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="449" mass="50398" checksum="441AC5095A0AE40D" modified="2018-07-18" version="1">MDFLIKFASEHESFRVPEIEALAIIENLDLKVKEYDPQSPFCVVQLPSVDAARKLLRRSVLAHSIHELWGTAPSLSALHPIIQSQTAHLWPQYKDSSFKFVVDAYQGAHSNKERLAIIDTFSYLPFDGPIRMSDPDETFTVFELWPFNSVPLKIAHPTLVRLGRFVASSARDVIHRYDLKKRGYISTTSMDAELSLVTANIALAAPGKLFYDPFVGTGSFPIACAHFGAIGWGSDIDGRSMRGEGDNKDKSLPGNFAQYGLKAQLGGFFSADLTNTPIRRRRTWDGIVCDPPYGVREGLKVLGLKNPENATWLIELGINEWQSPDYVPPKKPYSFLAMLDDILAFAADTLVDRGRLSFWMPTANDEEQEIPVPTHPCLEVVVVCVQTFNKWSRRLITYQRLPDSQVSSAELEAHEKRRREAAAANTGTTADDLNPFRRGYFRKFEAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWU6</accession>
    <name>A0A2T4BWU6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1404005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWU6"/>
    <dbReference type="STRING" id="983965.A0A2T4BWU6"/>
    <dbReference type="OrthoDB" id="3546297at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="257"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="356" mass="40013" checksum="FAB8C5EA5659D13C" modified="2018-07-18" version="1">MTPSLTLGRVPGPEGQSDQDQHQDNSYQVQPDIAPVRAQDLPPADTFGGIARRAMAPRSASPRSLEDSVEGRPRNNAARRAGAHGTGNHAETEDDDLDRLLVEHQREDIFHLQTSVGPLRSFVRSIGFYTRNLKRDIKPQVTMRLSLAALNRMRMRRLQVKLANRIMRMHYLEEVPEDWQILLEQYISATRDNDYIRTCVDRGLHDPFLIRGERMVDATILKDELRKIPPDKWEEYPFLQSEDGEKKFNFVPPLEKKPTAIGGTRTVMMRKQWTEDFLKRIVLSVVGGAFLVVPMWLMIKLNSQSASLITTTVFVFVSGIAAAYALDNAIAVISTTAAYAAVLVVFVGTNSSPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWW6</accession>
    <name>A0A2T4BWW6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1360685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWW6"/>
    <dbReference type="STRING" id="983965.A0A2T4BWW6"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="12086" checksum="CAC4B6C86374CF1B" modified="2018-07-18" version="1">MPLVDADAPPSTNDTHYVVYFASGEPSWCPDCRNALPALQSVFGADSAPLATIIHAGSREEWRDPSNKWRHAPYNINCLPTIVRVENGKEIARLGDVEGQQESALRKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX06</accession>
    <name>A0A2T4BX06_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1403979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX06"/>
    <dbReference type="STRING" id="983965.A0A2T4BX06"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="284" mass="30538" checksum="9773F7B4548B0E6D" modified="2018-07-18" version="1">MSSAAAVFAPGATALITGGASGIGLAIAKLCRSKGMKLLLVDRNAEALEKAKAEVGSSSSSSDVAISVLDVSKSDGWASLKDQAAKTFDSIELLVLNAAISGKGTWGDGDYFRNVLETNLFGVINGINTFLPVVQEAAKSRPTSIVITGSKQGITNPPGNPAYNASKAAVKTLAEHLSWDLRDTKTSVHLLVPGWTFTGMAMAHGIKEKPPGAWAPEQVADYLYKKMEQDKFYVICPDNETTEEADKKRMLWTVGDIIKERPPLTRWRPEWKEEAAETIAKTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX41</accession>
    <name>A0A2T4BX41_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1338310</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX41"/>
    <dbReference type="STRING" id="983965.A0A2T4BX41"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="921"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1001"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="111"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1131"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1229"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB73891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1277" mass="141182" checksum="AE600B8ABBFC7CC3" modified="2018-07-18" version="1">MDDQLITPVSVTRHHDHADADAEAGKQATQLVAELEAEQPLPANNFAFTPSQLHRLLKQRSLAALDVFGGLRGLVLGLRTDVTTGLSADEANLDGTIKFDEAVAAAREDRVPSVSPIEEPLAAPGLTFPRADSHQQFVDRRRIFGANRLPRRRQKSFLKLMWIAFNDKLIILLTISACISLAIGLYQSLTADEDTSNIEWVDGVTVVAAIVVIVLASAATDWQKNHRFEKLNERQQQREVTVLRSGRIQQISIYDVMVGDVLHIEAGEVVPADGVLIQGSSLYIDESSITGETQLVRKTASTERIGSRAVQPDPFIFSGTTVCRGVGRFLVLSVGEYSAHGMTLMSLREDVEETPLQAKLGKLGKQLILFGAVAGSIYFFILFIRYLVRLPQHKHARPTQKAEAFLHIVMLAVTIVVITVPEGLALNVTIALAFATTRMLKDHNLVRLIRSCEIMGNATSICSDKTGTLTQNKMAVVAGRVGLESGFEDLEVPVTGTSSRGSSSMPKLPTAKQFMSTVSPQVERLIKDSIALNSTAFQRDDSAGAEFVGSSTETALLKFGRDHLGMGRLGEERANTPVVTMLPFDSARKWMAVLLKLPNGRYRLLVKGAAEIVFEYCAFIVSDPTYQVTIDRLTESDRASFRRTIHDYAANMLRPVAISFRDFDENEVFEHPDDDPASINLEWLASGMVFIGFFGIRDPLRPEVVGSVRKCQDAGVFVRMVTGDNFLTAKAVAAECGIYTAGGVAMDGPTFRKLTPSQRNAIIPRLQVLARSSPEDKLLLVTRLREMRETVAVTGDGTNDALALKAADVGFAMGLQGTEVAKEAASIILLDDNFASIVRALSWGRTVNDAVKKFIQFQFTINITAGITTIISELVGDSIFTVVQLLWINLIMDIFASLAFATDHPSPDFLMRKPEPRNTPIVSITMWKMIVGQSIYQLLVVFLVHYVGWDLFNPGTEHEIEKLQTLVFNIYVWMQFFNQHNCRRVDNKLDIWYQGILKNPWFIGVQLLTILGQFLIIFKGGEAFDTKPLTGAQWGWSILFGSLTIPLGALIRQVPDFLVLELFRGVKKLCLFVITPIRNTWALVFARTKERPGDASQAELGSVAASGMSPSNAFIHQTGLPAANPPVGEASHIFSDTESQPTLNDNNSSSLAEYSATASISEKMEIDLQALIDAAKLGRLADKEMLEIHPRTLKNDPILTPRSDLNIPPSQDPYILRYFTGTRRNDARGFISRSEPRPTVPARATWVEPSRPTPARTREQPRRDWLSWEGLLRSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXA0</accession>
    <name>A0A2T4BXA0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1446562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXA0"/>
    <dbReference type="STRING" id="983965.A0A2T4BXA0"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="499" mass="57405" checksum="5B75FC5FF9F05CA7" modified="2018-07-18" version="1">MENEVPRLWLALAGLGLYLGVRTIYRLYFHPLSHIPGPKLTACSHLYEFYYNIIRPGKFLFEMERMHKQYGPIVRINPREVHISDPDFYDEIYASSSRKRDKDPKYVPTYALPGCMVAAVGHEQHRFRRGILKDFFSRRSVAELSDSVNERVQKLMRRLEADRLNGNIVSLDDAFSALTSDIITAYCCGKDWDFVEDENFRSDIRNAAENAIEFTHISRFVPWLVYAMSALSPRTMAWIMPGKAKLFEFLESFLEYGQMESHVDKRKTMVATLADPSIPEKERDYYRIRDETFGLLAAGTETTGRVSTIAAFYLASDSRVREKLQAELKQAMPTLDARPTWVELEQLPYLNAFINESLRLGYGITARLPRVAPNEALRYKGYVIPPGTPVSSSTYFIHGNASIFPEPDTFRPERWIEAAERGENLKKYLVTFNRGSRGCIGINLAYLELFLTLAHFARRFNLELHDTVLDDIRIVRDMTMGLTRRGGIKVYAKLLPVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXC9</accession>
    <name>A0A2T4BXC9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1404190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXC9"/>
    <dbReference type="STRING" id="983965.A0A2T4BXC9"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="448" mass="47797" checksum="A2C3A6D6CF0352FF" modified="2018-07-18" version="1" fragment="single">MDDIHELDNRPAPDRLSKGPPIHEEPNRALTPIPPQNNAIEPQPASPQAWRFWAIITALAITGLMSAIEGTIITSALPSITNALGGGDAYIWIPNAYLLAQVAILPLAGQASNIFGRRHLLLCAVALFTLGGGLSGAASSMGMLITARTVQGLGGGGINLLMETIVTDIVPLRERGQYMAIVGIGAIVGATLGPFLGGLITDHASWRWCFYINVPIGVASFGILFIFLRVKYDRDLTWSARFRRIDISGNAIFVAAIVSALIALTWGGTIYSWSTYHIVVPLVLGIVGILLFAAFEWTPRICPEPSFPRQIVSNRTSAAALVLTFIHAIVAYWVYYFLPIYFQAVRGLSPLRSGIYTLPNVAGGLVFAVLGGVLLSKSGRYKPLHLAGFAITTVSFGLFSLLDARSSDAAWVCIQLLNALGSGMLSGVLLPAVQAPLDESYVATATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXM3</accession>
    <name>A0A2T4BXM3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1404286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXM3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8691" checksum="C1EE2CD60B66A726" modified="2018-07-18" version="1">MAWEHQAIHGAWSWPTAPLALASVVQRSQSPSRRPPAQSRFYLLAAFPAFPSSLPAHRVREKTDECVGWTGKTGYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY75</accession>
    <name>A0A2T4BY75_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1043196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY75"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="11381" checksum="2C48B031E3643949" modified="2018-07-18" version="1">MFEPRLPIQPDSITYIQHLGCCLYCHRTFPQVKMHTYLRSTQGISVRPVAPPSLEHKRKHKRKHMHKHEHEHEQEPVIRCQPQPPMHSQAPLLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY81</accession>
    <name>A0A2T4BY81_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY81"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015537061" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="92" mass="10138" checksum="6EA0FE6B65A611CB" modified="2018-07-18" version="1">MTAEWFTLLCLSTISLTLRVSHNVSHNLPIMDTGLRPELNHSIRQVSVSDCLAHDNHSLGMPPLHTKGLKSTYGLGPAMNLYCSRASRLVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY99</accession>
    <name>A0A2T4BY99_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1440482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY99"/>
    <dbReference type="STRING" id="983965.A0A2T4BY99"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="253" mass="29008" checksum="3DAD0C72E5928BA7" modified="2018-07-18" version="1">MSILNLAIKSNDTETVKLVLGKAAENAKTSLSKDTIIKHATRPLWIKWFSWAVGKDYLEIAGQMLRVDGMPYYLNQDDRYLGRLLLLAIKRCRGADMATLLLEHGGDTPLMEATAHKDMDTVRLFLQSPRLNLNQRNHWGETALHKMISRRRPDIAELMLTWDGIETGQRDFKGHTPLMVCLLEMAGAADMSLYITLFKKLPIREGIDMETFRRDYATIVSQRLDNSRPEFLLELMVFVSRLHRPLMGYIMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYJ3</accession>
    <name>A0A2T4BYJ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1338110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BYJ3"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="449"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1371"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1602"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2302"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1377"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1405"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1452"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1464"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1493"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1510"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1531"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1560"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1602"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1666"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2303"/>
            <end position="2327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2327" mass="257280" checksum="0FC32869E9E7B1AA" modified="2018-07-18" version="1">MALSPPPLPSRFPCWCRAIYSWGGESKHDLGFIEGDLIECLNAGDGSWWVGRLFRDRRTVGSFPSNFVEVLPEDFRPTKTPSPIPPAASPSKSVPQKSRTFRKPFEAYAKAPHYTTAKQPETFREAPTSRARERPSRVGTTISRSRGNSTPIPSSALVLARSAHEDVARAPTPSHSPANAYVSRAPSPAPSAGRPPSRLEDMARGASPPPPAPPPHRHVARTESDEAPQGYHALSRHSSTVSYNQQSLSRQGSTLSYNPADIARTGSTVSYNPADLTRTGSTVSYNPADITRTGSTISYNPADMRSTVSYNGPEVSRSYEPYSPPRHPSNGSYTDLPNLARQTSYNSYDDASYGPRRDGYHTPKGTGSHRPSMEGSHMTPSPLREAMDGVMQQLDRLEGLGGREAQSPEGSFDPWSPESFDLVAPQQRQKQRERMRPLTSMGIALDEGYETWSGTSSQTTSHRDAHREKGYDLPQLSNYVERMEKQIQRMHQHSQSMPAVVDVDDDKPPPPPPKGQHYLRPKSSAGSTLGELVSLDKRSRGRIERTNTTKTTQTNASTGNQSNSSSSTQNSNRTLWSGVSASGFSATSAGSLARSGQRTQSSLSARNDEGDRPDSPFTGITYHSSHASNYAGGGSGSGSSRPISHVGLLEDGAPGLGGLVAPKSPKRNIFKKILDSAKTGVASNRGSIAAGHVPTVRSSPFSRLQQPHGVSPGTSMLSLSGARSRRDAAREMGQSSGVDWVQVRRDVNRSNSISKIERTERRDRCQMQDHPTLNPVDELYDGIEGDEGADGMPVHKPENYHMINLAQVDKNTRFIKEPPPGTTVTTLAQTYICRPYRSDLQRLRAIFTWVAERICWEEDFEGDADTQRTIQAKRGCAEEYAYLVMEMCAAVGIHCEVVRGYLKAPGDIADLHVMPRSNHWWNAVIVDDEWRMIDTCLASPSNPKRPLYSSITGSSADFWWFLTRPTEICWTHVPEHHDQQHIVPPVDYDTLLNLPCTCPAFFKNGLELVDYNTSVTRIEDLEMVHIKLNVPSDVELVAEVEARALSRDHDGDLFESGDIVKKRALAQAEWFSGVKRYTIKALLPGDEGQGMLKVYAGKRGLMQSIKDIPHPLAFTLPIIHVGENPPYQFVTRHPTPHAQRHDIYVVQPQCQQLALNNTFVFAIRQHPSSLSGGAQSALTPASNPGSASPVPFARPSSAMSVNASSASGSNPSSASGTVAGKKPAKLAIQTPGGKILRLMRKEDRKGISVGSRSPDEEVSDGGTWETIIKCSEKGVWRGLQPHKHTHTHTICFHFLARLLLGPFALYPTHGKSSMYAGAVAHEQQQQFYHHQSPQPQHQQHGMFMTSQQFQQPYAMGFNGFAEYDSSGQYLPPSSVWQQQQQQHQLQQQHHQQAMTNMAAQPHPMQHQALTHQPLPQQQQPLQQQVHQAQRQQQQQLQQRHQPSPIYHTHTPSPAPSLPPQPSPMRSQVSVPPRPQHTSQPPQHMPSAQHLSPAPQPSPAPQLSPAPPLAPQGQQPQQQRQGEQQHQQYTPPQQPQPPQRPQPPIPQPIQNAEQPQKDLPPEPTQPPQPPQPPQPQYVHPSELLQEQVHYVNLQDIQKQPSITSLPIPTMTTSTTNPLATQEKRKEPVAAKPIYPSAASIKQEKQEDESIATRVFQQVPDARIKPSPHSSVTNSPSLSMRSPSITKKSPAITPKPRPMNPTPYMIAVAEECIEKARNASHDVAMTLSPNQVEEYQGLIATALSCLEAALQSNNQLAPREEARVRLRYAALLQEETENLMEAETALAKGITLCDKHRMLDLKYCMQYLMLKVLYQRNHKAALKAIDGHISNCEVFKHVPWYYAFRLLKASFYLDIGSISDAGALDNIRAIQNVANTRGDIALSVLASLIEGFTLLKTAKEGNMEKIQACIAQVAKYQFDPSVQITQLTMMTMLLEVAASLHHQSPDHTAQKLRQLQLCLDDCEGWHNVKSDFVVPIKKEPSAARTVSDETQAILRVGEGEMDHLVMTFMTKMELRSLVFTISGLVNFHKPSSQGRRSTEFWKEGLKILETWDASTAGIPYGAPVPLNVAIKQRAWRTEAQAYLTVLLGFVAASHCQWSTVKQLLQNLETLVSPSTQPTVRLLSTYLKGVYHQGIGSLQAAIDIFLDDRFKVQQQGNTGIKAGQQEVALLAGLNRLWIMQHPSCRNDQETQDLSEQLQPHCSNHSNIDLRTAYHNVMAALVTDPPQQLNQQKQHIHAAMAGSKVTSNVLGAAVTLCIMRSRFFENVIGEQALKSARAAAKQAERSGNVLWQSVADGMLAQSYEVQGQREEAKQEWDKATEEARDAFARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYJ9</accession>
    <name>A0A2T4BYJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">M440DRAFT_1440557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYJ9"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="12422" checksum="3DCA249DA957D1B9" modified="2018-07-18" version="1">MASAAADDAGHLTLDVEFSGGLEMLFSDRRRHSVVLPAKDQDGKPSTIASLIHHLCEHVMEDTRKELFVLQDHLRPGILVLINDADWELEGEEEYELKSGDNILFVSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYK7</accession>
    <name>A0A2T4BYK7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_115846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYK7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="167" mass="18368" checksum="6F03375CAE31F64C" modified="2018-07-18" version="1">MKREGKRGIQLNDTCGPAANCFGGNDKRGEVADGLPRVEGDFKVSGTFLSAAICRQAQGREALCSYTRLRCSSKVSRTSSSTVQKAPMAAHPPGRNDHVRVRCRFDLQGPVFIFLAIGRDQIHYQGDDVNFPDLRNAPRSSTKPAMGIAMNKSFPSLERWALTNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ25</accession>
    <name>A0A2T4BZ25_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rad1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1392878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ25"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ25"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="321" mass="35668" checksum="F397659D9453D93E" modified="2018-07-18" version="1">MATETKPIFRAVSTSPRPLYQLLRCIDFAQKVHVQITEDGIRFAADNSRVMQGVAFLDKTLFSAYTVNFPLSEDGEPEYPNFQIPLSTFLEVLQIFGSVDVAARAQKADQDPYRSNIRNYRPSAFSNQTLGIPGTCTLLYAEEGDAFKVTLEESGTKTTAGLATYLPEMPEDIPFERNDLTFKIIMSSRTLFDCIAEIIPAGPVKLNIAATKTSPFLTLSCAGDIGSSSVDFARGKDLLETFTINDRWSQAYKFDFIRHASEAMRIASKVSLRGDSQGVLSLQFMVDVEGGKRSFLDFRFVPFASHDDGDDDDEVDSEAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ59</accession>
    <name>A0A2T4BZ59_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PhyH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1471235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ59"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ59"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="307" mass="33830" checksum="06397DA8973655C8" modified="2018-07-18" version="1">MTCTQHYTTAEFPSEAGKEITTVYADDPATDAALLKSIIDKDGAVIVKNLVPQSLCAQIRTDLKPIFDADKPDPAGFFPSTTKRAHGILAKSPSSAQLVVNPLFQSVAERMLTSRYTYWEGQEKKTVAAKPQVASIVGFRVEPGGKQQPLHRDDSDYHTRNCDMPVMLGCVTALSKTTKENGATVIIPKSHLWGPDRCPLNEETISAELEVGDAAIFVGNVYHAGGANVTRDDARETIGVFMCKGTLRQEENQYLELPPELAKDRGFSPQLLRLLGYGLCPPALGLYRYKDPMEEIFNVLDEETIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZG6</accession>
    <name>A0A2T4BZG6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1031327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZG6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18442" checksum="7C119CC027E71487" modified="2018-07-18" version="1">MSMIYSMAMQSTGLNFSYRICMIRIGRHWSVGRKRCGTPAAPRGHDDPRDVPRANASMQESCSSWPASSTGRRCRGAAVEGNKQRGGEMDRETLKQIGQMRPVTKEKGVGCRRQRNRYHPVSARSLRSGFKNGDLVNRPPTGRNYRAGPEVNICCQADGTPCVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C098</accession>
    <name>A0A2T4C098_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1266648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C098"/>
    <dbReference type="STRING" id="983965.A0A2T4C098"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="681" mass="76989" checksum="E0034A9670D22525" modified="2018-07-18" version="1">MKKSIACGACRTSKRRCIHSGGPPCIRCKERGDECIFPPKGTSFIFRRSRLERQQRAASSALATDASTVSSLLSAAAGPQAEATDDPEEQPKVNLWEKDPLEYVTDEVKESYMRCSYKWSFHHMPTFFAQIRNKTLDRSVAWAMLAITVRFSQQPPEGFSSQIQTSNYFAAHTRSLILPSIDEPSLQRIQVLLMLTGHSWGSGEGRRAWVYLGMAVRMAQIMGLFEDAPVTSPDTQDFIHGEERRRTAWTCFLMDSLLSGGKGRERLLSADSMQIQLPCDTSNFIFGEPVLCPFIEGFRSDGTAKLPRGNPGIVAYSMRVADVWGAVAKWSCSSHPNNTPPWQAESELQRLLLRLNAWKDSLPSRLRYDLSLLHAHSVQNQGQAYCYMHCIYFMSVIFLYRSYLPELELHEESKPEDGDRKQWTEFSCRELARVADQVCEMLQDIRGFGFFFLRGLVPWIGFTIYTAIGTLLYFWHFPHVSEGDPQIESWRQRIIDGCVFLKDMRQAWPMADTWRETIKAMHIFYSNVKSKGNQAMSPSARREMRNAIIDYGALQPSPVQPADSGSEEDAMVVSEEGKVRTEVLSMNGLNTTALNSSAMNTTEMETTEMETTEMNPNELDTTEISPNESELISHEFGVVPPADYDLFDTHFDIDSAMQASFADATQGFWEGFPGNVEISGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0N3</accession>
    <name>A0A2T4C0N3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_55747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0N3"/>
    <dbReference type="STRING" id="983965.A0A2T4C0N3"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="31314" checksum="6CCA5DCAF75CD25A" modified="2018-07-18" version="1">MAPLVWLVTGCSSGFGREFIHEILKRGDKAIATARRPETLKDLQEAGAAVLQLDVIWDQKRINETISDAIAIYGQLDVLINNAAYCLGGAWEDLSYEEFRDAFETNVFGPLKVTKAVLPHMRARKTGTNVFISSISGWSGMEFNGGYAGTKFAIEGMVESLDREVKPLGLRTLIIEPGFFRTDFLSQGNLKTKESSIPDYVEASKAFNRLLEEKNHAQAGDPKKGVAVVVDLVRQEGVAKDKKIPVRMALGQDAYELIKGKCRKTIELLEDWKDVISSTDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Q5</accession>
    <name>A0A2T4C0Q5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Q5"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Q5"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="309" mass="34983" checksum="D79C847EE3CD122A" modified="2018-07-18" version="1">MDFTPEPYDDNVSSSWLICNTCGTQFPTADRSALKTCYACDDPRQYVPPSGQSFTTLADIRATGHRNEFTPYRHHERVISIRTEPRFAIGQRAILIRTPEGNILWDCITFLDDETIERIRQLGGLKAIVISHPHFYSTHVQWARAFQCPVYISAEDLRWTTTPSAHRKPLTEIESEIVPGVKAIKLGGHFPGSLVLLFDGRLFTADTLMTTPAGMGKWDVDALGEKREKPPGLNSFSFMWSIPNYIPLSADEIHRMWGVLKRYEFRSTHGLMIGMDIEDDKVKARVLDSMKIQARAMGNVTHALLDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C150</accession>
    <name>A0A2T4C150_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1423348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C150"/>
    <dbReference type="STRING" id="983965.A0A2T4C150"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="17770" checksum="1761A3564497742A" modified="2018-07-18" version="1">MDIDESDPQHEEIWDDSTLIDSWNDALQEYKKYHSIHARGGSIRDLEQAEVDLSKANMTPKIEESKETPDPDLSDKGADAIDDVPAEKQSESTQPAHGLNSMPTPFPPQAILGTVRDENLKKLLMSWYYAGYYTGLFEGQQQAQQQSQQQSQQKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1B7</accession>
    <name>A0A2T4C1B7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PhyH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1336259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1B7"/>
    <dbReference type="STRING" id="983965.A0A2T4C1B7"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="334" mass="37159" checksum="65E9E9696A2F5347" modified="2018-07-18" version="1">MSYPRPLSGGSIPREAGADKRLARPYSSSPPTPRIQSLIDEVTAHGYVVIRDAFSPASVAAAKAEVARLTADPETAGPAGIKGRNTFEGHRTQRLYALPDKSRVFDEFVLHEDVLALNDWFMDPGYLINSFQSINILPGEKAQTMHYDHGFVSLERPHRPLGTGVMIALDDYTATNGATVIVPDSHLWDSRRMPKPEEAIPVIMPAGSILYFVSLLWHGGGANRSDRSRLALTAQYCQPWIRPMENLILAVDWEKLDGMPARLVDMLGYKVGNPFLGFVDGRSPRWAVERLLRKYRGEREKGKGEGKEKVKGKEKVKGKEKVKGKEEGKEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1R0</accession>
    <name>A0A2T4C1R0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_20555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1R0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="28449" checksum="26C43324BDA80812" modified="2018-07-18" version="1">MSVADVMLQVQASNTSPVPCVPAVFTPSPTPNRQFTSFIRVRDRGASVQRYNPRRAKELARAIATKKSNRTATSVESDFMCVGPVRGKWSGTGPGTGCEWRLALLHTHDEVYTRDCAAQTLEVSRQLLPHTLGFQSPSEGSMCTGIELSPLMRHEGAVSLVIVPILSSQHADWNECHRPHFAHVLAQSTAASLDARYTKQTQHRRHSMKVIGMRAYPPKGTHPFSVAHVPQNGEHGKRMKRAQTAPVVSLRLGPATSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2M4</accession>
    <name>A0A2T4C2M4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1378463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2M4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="121" mass="13861" checksum="8051D3805B745A85" modified="2018-07-18" version="1" fragment="single">SALRAALIFFSSCFNHRRWPEKKLEIFCRDKQRGVLTFICPSLLASDYLPFFFFSLHPKTLPLDRTGFILSAVHPSDPFSLPINAFFTTPFDSQTDDDYDIHSFFKTVLPSGHSSPRLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C318</accession>
    <name>A0A2T4C318_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1265150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C318"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="14048" checksum="66221F3F846E577A" modified="2018-07-18" version="1">MRIHPPHRCLHRLPRANLHRHRPRTQCRLCLRCASARCERTRTSFALPSWRCSCAGGASWTIASPDVRAGHCHPGKRRLNPTRLEPTVFQSDGSLCRPLLSWAAWILDSSAQSLPHTVTPRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3K2</accession>
    <name>A0A2T4C3K2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1422252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3K2"/>
    <dbReference type="STRING" id="983965.A0A2T4C3K2"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="376" mass="41580" checksum="19CCFA41C7D02EF5" modified="2018-07-18" version="1">MAGFLSPDEAAQSHADLVRIPSIVFFAVTPIFIFIRFWSRISRNSGLGWDDGTIAVSFVCTLLVQIFMMISCNYGFGKHIASLSVSDRLAALKWFYVAQIFYKLTINLTKMSIVLLYLRIFVQRWFRISCYILLGIVSAYAVASTATSIWQCTPIRGAWDKSVKPTCISLTMNWYANAGYSIATDVLILLLPMQPIWSSKLPLAQKRALMVVFALGSFVTVTSIMRATTLNFSTTSPDTTYDITSTLWTIIEENVAIICACLPMCRMVLAFLFPKIFGGNTSKGSTGASGGLGSEGRNKYGYARSRSPTRHQSWKPYSGPGGDGVSRSMAAHQNDDTSEEFILTTVQRHGSTDDPDGAIRKTTKYEVSYESGPYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C401</accession>
    <name>A0A2T4C401_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1401744</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C401"/>
    <dbReference type="STRING" id="983965.A0A2T4C401"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="566" mass="61404" checksum="813628FF54E86644" modified="2018-07-18" version="1">MAALFEQPRNGTLFLGGQKISGSDIRDQNVLATQAIANVVKSSFGPSGLDKMMVDDIGDVTVTNDGATILTLLDVEDPAGKILVDLAQQQDKEVGDGTTSVVLIAAELLRRGNELMKNRIHPTTIITGYRLALREAIKYLNENVSIKVDNLGRESLLNIAKTSMSSKIIGADSDFFADLVVDAIQAVKTTNNKNEAKYPVKAVNLLKAHGKSALESVLVKGYALNCTVASQAMPTRVQDAKIALLDMNLQKERMKLGVQITVDDPQQLEAIRARESGMIIERVEMILKAGANVILTTKGIDDMVLKMMVEKGAMGVRRCKKEDLRRIAKATGGTLLSTLSDLNGDEKFEPSYLGHAEEVFQERISDDECILIKGTKAHSSASIILRGPNEYSLDEIERSVHDSLCAVKRTLESGSIVPGGGAVETALHIYLEEFAGTVGSREQLAIGEFAQSLLIIPKTLAVNAAKDAAELVAQLRSRHALSQRIQEGDANEDEKTIAKKKGYKNYGLDLTKGRVVDEIKLGVLEPTISKVRQLKSAVEACISIMRIDTLIKLDPEQPAEDDGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C414</accession>
    <name>A0A2T4C414_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C414"/>
    <dbReference type="STRING" id="983965.A0A2T4C414"/>
    <dbReference type="OrthoDB" id="5417628at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="563" mass="61915" checksum="9B3B663610EE17D0" modified="2018-07-18" version="1">MRFEDWDVLLFPRDCKVPMKEFKVACHVIHDAEITSPHGSFGLPTVCCFIPSLPAGTPFQVSIHSWSSPTVSQFTKCYSKYGDDANFEARVFIDGQLVASARLDREKDWPHIIIHSFGVSKNGDLEPLRFPNFRQELLRQNHWHPADNFGRIKIVISEGFPRDSLSLPMERVKNVVAFSFQHAPLEILENSCIAWPNPSMWRRIPAPATRAVQAYPSDDTDSHAHSPRRKYTRISANPPLSSTSGNLQGTTNTRGVRTGQRMSDYQSGNTRAASGSTSTGTLETISDSNAYFEWLNGMVTGVNDSYQLVEHDLFAPGQNGRRPPSGVPPFIPLGNYLDQSLALHNFRNEGGRDQFEYLRPTAEVPDVEALCSQETQDLFLPRLSQDNMLTMDTPTSLAHSLLNQPMPTNLFGDSTRTAAPEARPHQASDVHQAPDPSPSSASTTSTSRKNHATERKTARRPHKAHNASVQAGSNGSGYVSSIPDASHQLASVEDYVSALEARLAEDAAASNEAPPSTDRGTKRSHDSASGPGSAVMSDEDQRRPSPRVHITALLTQSPTLVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C454</accession>
    <name>A0A2T4C454_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_4839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C454"/>
    <dbReference type="OrthoDB" id="4900331at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="87" mass="10004" checksum="2AA131C6F58A9413" modified="2018-07-18" version="1">MNGNTRERGRTPTWINSSRFEDAPYSHEPIDHLIAAIVFWTIMSIFVVCFNMNCEWLPILLRSASSLSSSRWLAWPWITTSCDLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4A6</accession>
    <name>A0A2T4C4A6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1333863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4A6"/>
    <dbReference type="STRING" id="983965.A0A2T4C4A6"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF6">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="225" mass="24183" checksum="F8483AA81EE185D0" modified="2018-07-18" version="1">MPQPHEAPSSSLALTPLNRILSPPLGLIPPNTPPRLYSSCVSHFLSIPWCACLIQTPNTVPFIPQCFNPKSPAHDQLVGATLAGPRGLQHMLCFFHTEDEAHLQDAGRPIMHVSSLFALGEGLSGYEGVLHGGMIMTMVDEAMGVLHEINLALGKTGEIFGSASVTAGLEIKFLKPGPINQTVLANAWVDGVEGRKTRIKCELRDGNGIELAQCSSTWVSVRARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4T8</accession>
    <name>A0A2T4C4T8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1377851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4T8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4T8"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF17">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="315" mass="34734" checksum="334C2DCFB02C1FA6" modified="2018-07-18" version="1">MVLNDNPPFGPVVNGSMIVVFWEYRPSNAAAYTFLALFALATFGHLVYFLWLRAWIFIPLILGGICEVFGYLERANAHSQPTKLDPWILQNMLLLVAPPLLAATVYMSYGRVSTALLYGTTKQSSRRKDRGCCAQCCYACCCTCSPTRGYVLVDIAAIFTQLIGTILPASGTADALRLSKIIVLVGLFAQLMALAAFVIICGRLYVRLWRNPSMSRAMLTDPGVNWLGYLTVLEIAAVMLIVRSVVRGAEYLGGTDGFVASHEVFVFVFDAVPMLATVAGFLVLHPCRLVREVVRFEGKGSGELAELREQRRLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4U5</accession>
    <name>A0A2T4C4U5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1356721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4U5"/>
    <dbReference type="OrthoDB" id="4876394at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015530813" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11917" checksum="8BBBC9A72EF8F142" modified="2018-07-18" version="1">MQKAILYILAACPAVLAQIPVLFDSYTDGRCAGGVVVGTTTVQPADCTSSTTAFASAQYRGRQFDNAEQPVEFYSDENCVDRIEGVSVELGDGYNCFTFNDGQAKSAKWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Y1</accession>
    <name>A0A2T4C4Y1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Y1"/>
    <dbReference type="STRING" id="983965.A0A2T4C4Y1"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49347" checksum="21BA18829D442CDE" modified="2018-07-18" version="1">MPVKSLRDLAMAAIFKNIREVEDVGDLPYEAVRPILMRVDHGAQLRQIELNSPQLQGQTAEVWVRLIERDFPLEARNRAYQPKDPKKWYRVWEKYKADQDKFLQQSENTLLSRLTTIKKEEEKNTSKIVELGAIPRSKKCALRGPRTAKTSSTLSFAGGSRTKAVNGASVMRKVRREVKEIAKIHGSLSQPVKAPTARSAVTKAPEAMVNDQKRATLPPYRPALLKEKRVLDPELRWQFAQDPEAGIRYLSEAALEDYQSRASFISDSEESGDSGNTRHKQPAPAAPKPAAPKPAALKSATKPAAARPAAPKAPTNSLQRKFGNSKSAFKAPTAPSGPVIKAHESVTKPKPKSQSQSQPQPQPEQSEPKRVRLRAFPAPDLPTTRTTPEGDEDDGPESGSDVLMRADAKAAAEIERKAPAAAARMTQIYRKRKAVDIFAHPKKRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Z1</accession>
    <name>A0A2T4C4Z1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1456216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Z1"/>
    <dbReference type="STRING" id="983965.A0A2T4C4Z1"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="147"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1216" mass="131365" checksum="D815306E67F2C2EA" modified="2018-07-18" version="1">MSYKRSRATFEADLHAPFAIFGTPLPEDGERDDGSYLPLWKQEVRDEKGRRRLHGAFTGGWSAGYFNTVGSKEGWTPTTFVSSRSNRRKDDAGHSQQRAEDYMDDEDLADAAEAQTLKTTQAFAGLGSSTQEELRAGGLMGLFRADGDTMGLKLLRRMGWKDGQGIGPKVRRSARLDVGVNSSAADGEMHLFAPDNAEVMRFIRKTDRMGLGHNGQRKLSALRHDSKADSDEEDAPGDDTLSILFRGDSKKKPQRGGIGVGILNDTGSDDEDAYEMGPKIRYNRVIGGDKKKKGKKLSAAANPSLKQAPVFIPKTSRVGGSLRRCQDGRLPLDGFVLASATPDLTSALAKYAPPPVPPGWKSSKAVDVSGQPAKFVSAAEAAKASTLDAKSRAAILGEAPLPGKSVFDYLSADARQKLAAASGRADLPPGRGEVPEGYAVSEEEKQARLWEQAPKLDRETAAAAIARGLRGPYSDDEAKRARYKRYLEHHTNPKLPPPEKPRGMSDDEFLRELIEFHNCARIFKPMTGFMASKFTTAKAPHVISADASQKTELVSVPEPKPSDPAEEAAKMGMFGHMTRSVQDFYPTRLLCKRFNVKPPAHARRDDEPESGKAATGPNARSAYGNPMDDVEMPSRTFNETSMGTEATAAATTGTTIPPSKQTPTVERQEGQVNPDRNEAVEGQTANVEVLRAIFGDRSDLTVSGVLICLSCAGVKSSGPARRRGYPISSRSSSTAAKPLFAADDFGLPPPFFTLSCPTEYEHEHEHAAATATATANAARQQLDIDAADNVSAAHEAEQSPPPQYPVSEASSSSRPPPFSSLFSSVQDHPCGEPFGKFPAVVAAEGSASASVAAPAYGYDSDSRAPEPVDPDQAAARAFQDPVAETKRALPRDTKGESSRKDDDAEPPPAYSEGDSPLLTFSYVMAAAGGASSIITQVQQGGPPINAIGDVGADETITMDLRGTRFVLSRDELLTLPEFVLLSLFPNGLFPEGHMSGFPDSDAVQVDYDPASLQYMLDFFRNVAQSIPTESSPGASQDGEIVPLDPMGSREDTSKRAGIIVLREDLDFYAITPNSTITKADMIEVKRAAARALLKQDGIFSGLKRSDEPGTTEAHLIEMLTAGGFNHDDRWGHRAGEPNKAVICSLALARLRSDIRGNEMGNNAVGMAQKLLLFWRKPARRCWWEGIELENVEGVEGKLKVWIRRVWTLEMSVIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5A7</accession>
    <name>A0A2T4C5A7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1234075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5A7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="172" mass="19461" checksum="F5641926A00177B9" modified="2018-07-18" version="1">MAIGRGELELHALNETTSVRSLPRRLPEMQRALRVGSLTGCWPRRGVAARRNAEPVSGQRHDFASPLVFLVFSAREARVKRAKGFLCLPLTTPEPRSTGLLMACRARMRGWFQNREGPPPSAKRRTSSPGPQHLESNSRSQPRRPERILEMVAWVAFPYFVLARRFFGLLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5N4</accession>
    <name>A0A2T4C5N4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1331954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5N4"/>
    <dbReference type="STRING" id="983965.A0A2T4C5N4"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2" evidence="9">
        <location>
            <begin position="391"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="799" mass="86767" checksum="2C09C1284F5CCBF4" modified="2018-07-18" version="1">MAEPQYTVFIRVPIPRRGFVDPPPISWDAAKDEALWKILSGHKEIDWNLVADRFEVPVDFLVQQVAYLNERHQSHFLAQVRKATAAAKGSATQSPVPASDAGHLRTPSALSIRRDVSTLRNESGAAGPAVNSPNRPAMSRNTSGTTTVMRDGGGASPRIGTRPSLRALDQAARTRLSSLPIPSPSPKSPELPVAETNRANSPGPAESSSSSSSDDESLAVQSRIIRRPPRYQPPQDSYPYPVDEDDESEPAFRPYNAPSAGPSSSPDLSSTLKLRNAGPSGGARRNPRPFAKDSHHSQTSDSSASSPAMPLRPVKARESNNVDPSSPSRRATDPRSSRDNSEGTPSISSSFSDLDGMSLCLNMLTWHNRGTEKTAAMFRRLWSGLPEDVTFPSDLKGLGYFVNEDDEIRSIEQPDNYFNFFINRNPRICARQRFAFNHAMEAIVHERLEKEGMQKLRLPQGTPATEPHIPIFITPNLDTKTRIVVIFGEPTQDLGIVAGRVANGPGGINEGSMVSIVRALASQRSSPDDASPPGIVLANTGQTYWWPEGKRAITVSASAALPLPSLMHKGIREVPSLNGIPGNENPREHVKCVFDQVLGCMAGEQAVVDVVAIGETCEIVEKFLDGKEAWGVWGKRLGSLVLLGPVFEADGLTNGEFKDFLAKRARGYLLCSEPPGIPLAPPEGNPELSILPMGFPCVSSSEPSHVETILIQARAHILSHLQDVAMNPGYENPVIALAECLRPALTEQDWVDVPEEEKPVVSKADPTELKKELKQAKRWKKFAETGVAPDTDSESDSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C614</accession>
    <name>A0A2T4C614_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1331888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C614"/>
    <dbReference type="SMR" id="A0A2T4C614"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015550677" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="148" mass="15655" checksum="585CA5A863C6D1CF" modified="2018-07-18" version="1">MQFSLAIATSVLALTASAAPTLQTRDIASGTDQNGSIFMFGDPAGPRQLLFQFGACGLSTYFANQVDPSMPLVAMPAGVFDQFGAAQNNALCAKVITMTNNGVTRQAVVADRNLSVDNSIDMTLDLWEAFGGHDNDGTLIRGFSWSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C632</accession>
    <name>A0A2T4C632_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ER membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1241368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C632"/>
    <dbReference type="STRING" id="983965.A0A2T4C632"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="281" mass="31474" checksum="B38A77BBE9C2E3EF" modified="2018-07-18" version="1">MAPPPPNPNLPLKERFLALAQTLQFAWFVGHLTLLLTTTRYALSWLFMNYYSGMAQFSYRTSFVAAALTYGIVVYKSQRARAKTGARAPNGVIGLLADENVQYLAMALVWLFSPQYPLALLPYSVYSVFHVATYSRQNLIPVFHPPPPATDGVSQPKVNNPLANKIGNFVKEYYDFSMTVVAYLEISLWARVLLSAILFQRRSWILLGLYTIFLRARYAQSTHVQSSFTHVASRAEHFVSAQGTPPQLKQAWDIVKGIASKFHDATEISRYTGAGPAKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C774</accession>
    <name>A0A2T4C774_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1400292</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C774"/>
    <dbReference type="STRING" id="983965.A0A2T4C774"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="80"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="260"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="455"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PTB77372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="532" mass="59528" checksum="31FC72EF336E5A25" modified="2018-07-18" version="1">MADRLADQLQSSHLSDGVPPRNEDWKQNLNIPAKDTRQQTEDVTKTKGLEFENFALKRDLLMGIFEAGFEKPSPIQEEAIPVALTGRDILARAKNGTGKTAAFVIPALERINPKISKIQCLILVPTRELAMQTSQVCKTLGKHLGVNVMVTTGGTGLRDDILRLQEPVHIVVGTPGRILDLAGKNVADLSECPMFIMDEADKLLSVEFTPVIEQLLQFHPKDRQVMLFSATFPLSVKDFSDKNMTSPYEINLMDELTLRGITQYYAFVEEKQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHARMQQHARNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRFGHLGLAINLINWDDRFNLYNIERDLGTEIQPIPASIDKSLYVYENPESIPRPISNAPKGALPQQQSFPVQVPALTQTAHNQQQQQQQQQQQQQQAQGNWQPQNGQQNANSQYNNGSRGRGGRGRGYRGRGGGNNASNGGGRGRGQPPRDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7P2</accession>
    <name>A0A2T4C7P2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1353740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7P2"/>
    <dbReference type="STRING" id="983965.A0A2T4C7P2"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="523" mass="56275" checksum="13FA252077C857AC" modified="2018-07-18" version="1">MMVEPKEDEALDVQIMPSEPMTKTVGETVAEDVAKGDEKGKIVDIEAGSVVEAAKGYYSRLSVWLMVLFSGLAIGSDGYNAAVIGNVELLLGAIYPNDLSNAIYSRLSNAFLIGMIIGMLFFGVVVDQLGRKTGAVATTILLVVGIAMSAAANGTSPEGLFWMLIIARGVAGVGAGGEYPVSGAGAVEATDESRRYRKHRGFMFAMLADLSSDLGYVFGGLVPLILLLCVGQREDRYDIVWRTSFALGAIPPLGIFWFRMRMAVATAYRKSAMRKQRVPYWLALKRYYRPLIGASASWFLYNWISIPFGIFSSTIVNRANVGQSLTKSLGWGVLINCFYLPGPFLGGYLSDRIGRRQTMALGFGLQAILGFVLGGAIGPIQIVFPLFVVLYGIFLTLGEVGPGSTVVLTASESFPTSIRGQMMGLISAWSKAGAAIGTQVFTAILNKYAGNPDKGNQVAFLIGSAFAVLGGLVAFFVIPDVSRRLEDDDEAWKVYLADHGWEATWGDAETRDPKGVVMNCQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7U2</accession>
    <name>A0A2T4C7U2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_51006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7U2"/>
    <dbReference type="STRING" id="983965.A0A2T4C7U2"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB77640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16498" checksum="F31A5C6055660BA3" modified="2018-07-18" version="1">MALKRINKELKDLGTDPPSSCSAGPVGEDLFHWQATIMGPGDSPYSGGVFFLKIQFPTDYPFKPPKVNFSTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRPRYEATAREWTRKYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8A6</accession>
    <name>A0A2T4C8A6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1400699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8A6"/>
    <dbReference type="STRING" id="983965.A0A2T4C8A6"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="23654" checksum="4A065239EED3A694" modified="2018-07-18" version="1">MAIKHNQTLVSNHFRKDWQRRVRTHFDQPGRKSRRRTARQAKAAALAPRPVDKLRPVVRCPTIRYNRRVRAGRGFTLTELKEAGISKSLAPTIGISVDFRRQNLSEESLAANVARLKAYKERLILLPRKSNAPKKGDTKTDVSQLDRVSSIAAALPIASVSEGFSEISKSEIPAGVEGGAYTKLRIARSNARYQGARDKRARDKAEAESAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8J0</accession>
    <name>A0A2T4C8J0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_293361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8J0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="181" mass="19534" checksum="811FB7605DA10F78" modified="2018-07-18" version="1">MSLLSAWLPGDMDRVWSAVSSTTAACIAPASDLLQIHTQSLDENNRISRIRYIQTAPASRARDPSSNPSAPSALAPEKIPRGPGLIPGWDFPPLSLPPAASPTRTGLVHGYCWSLCRPSLVSFKVDTFELDCRFRASELATVILCSLFLSGVHFGIADLCPLASAPRHPISENPWTPFLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8L4</accession>
    <name>A0A2T4C8L4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Phospholipid methyltransferase</fullName>
            <shortName evidence="18">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1400790</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 18">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 18">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="18"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8L4"/>
    <dbReference type="STRING" id="983965.A0A2T4C8L4"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 18 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 18 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB77852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="209" mass="23116" checksum="38155CA4B490F925" modified="2018-07-18" version="1">MASSFDVGKYIDFDKQSLLISAGSIVFNPLFWNIVARQEYHNKILTRLFAGNRYVACYALAATIFSLGLLRDWLYKVALSEQPSHPALTSLYAQAAGYTLLLVGNVLVVSSTWRLGITGTFLGDYFGILMDEMVTGFPFNVTSAPMYWGSTMNFLGTALVYGKPAGLLLTAGVYLVYVVALRFEDPFTAGIYAKREREREAAKSGKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8N4</accession>
    <name>A0A2T4C8N4_TRILO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">M440DRAFT_295430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="PTB77894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="211" mass="23124" checksum="81E0D515A0ED3F41" modified="2018-07-18" version="1">MRSVRGPGVIGELDAVAELVTAVDGKQLGVAWQLSFSVWLPCFSASSLLYLILLSESWWCRNGLWPLPVFPGTCQSTKRHLPSNLNLLVNALQPAQQMSPYIRARLSLTWEPPFVFPSLSWAFFLQVPGTPCSTLQYLGFPLSQSARLFVETRHRHQGLAAGKALSLSLGLDRQPTSLAVKTQSVWSQDVGFLAAPASFLHSVAGIAHDPR</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">M440DRAFT_1184350</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">ATCC 18648</strain>
        </source>
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            <dbReference type="EMBL" id="PTB78093.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="17129" checksum="ADC125D919CDC358" modified="2018-07-18" version="1">MAFGMSWPLNGECTKGVGSQVIAANRQYLSLSVAARLLRWRNDRSCGFARVRQLRSRNTRLLLTARRRERSIFMLTDADKTIQERPSHTRSSETCRKKQNLRRIPSLHATVAALPAQLVGASWDSSKSAQSRAKPAEACYPYLPPGLSIPSSSA</sequence>
</entry>
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    <name>A0A2T4C9C9_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
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                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4842213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="11940" checksum="F001AD187E49C469" modified="2018-07-18" version="1" fragment="single">RGEKKRPRWMSQVKSWLATSEPSVQAMKNQKKDVFKKHGIDLNDPLAAAKMHSPMGKVPTDAVTSTSGPTPEQALKEKGRAKDRAASFGRRGHGPQSPVSSSFSSLPSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9D2</accession>
    <name>A0A2T4C9D2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1399356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9D2"/>
    <dbReference type="STRING" id="983965.A0A2T4C9D2"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="274" mass="29350" checksum="594DAB8A80AD6BB2" modified="2018-07-18" version="1">MSYIAAGANPNGAQATLRDGNRLKALFDANKPALGGWQMIPGVTISRLLAQSGVDWVAVDCEHGGLDDRAMHEAVPAIAALGVSPIVRIPGMEPWMVKRALDTGAHGVLVPLLRTVQEAKDLVQASKFPPWGQRGFGSPYSAKQFGRTISSAEYLEQANESVLTMVQIETKEALEAVDEIAAVEGIDVLFVGPFDLGNNIGHRITAEGIPPQLEEALLKIQAAAKKAGKKSGIYTLDPQHAKTCQKQGFDMVHIVTDYMGIEEIAKQSITVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9I1</accession>
    <name>A0A2T4C9I1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1437218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9I1"/>
    <dbReference type="OrthoDB" id="4897217at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="168" mass="18437" checksum="8EAEC6E6118B4B26" modified="2018-07-18" version="1">MADLPPPPGCPLISPSKHNRIVIWRDEVVSASASYTAASNYSAPSLVTTTTASSTSLSPEELATMSRGSRLWYKVKTQLAGKARRRSSVTVNTAELPDFLMPPRKGDVTRTAMYQSLRPGEPRPDSGDDEVVPGQDSKDDSLQPFLPTYTQHNWERAHNITLACLIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9P9</accession>
    <name>A0A2T4C9P9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1316693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9P9"/>
    <dbReference type="OrthoDB" id="5313995at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="140" mass="16174" checksum="55AB86E609384416" modified="2018-07-18" version="1" fragment="single">MKSTANMHPFYRLFFSKLDPLIMIYSAYRNILTNTSANTNTSALGLYDLDEELYYINSTYHSPNQQQQTFALVAALATMAALVQHYSDDYNLWRIVQLVLLVWNFSFFGGTTYWWWWRGNGTAVGVEGVYCTEVLTLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA53</accession>
    <name>A0A2T4CA53_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_261872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA53"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="9">
        <location>
            <begin position="28"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="391" mass="43027" checksum="855DE4D92C48DF09" modified="2018-07-18" version="1">MTVSNGNRGLLPMMEAVPSIKAQVPVWAYIVNWMFFSNVTIIFNKWLLDTAGFKYPILLTCWHLIYATIATQILARTTTLLDSRRTIPVNGRLYLRTILPIGLLYSGSLICSNVVYLYLSVSFIQMLKAASPVAVLFASWAWGVAEPNLSKFINVLVIVLGVAISSFGEIQFSWIGFFFQIGGTCFEAVRVVMIQVMLSGEGLNMDPLVSLYYYAPVCAVMNFFIALVSELPRFKWDDAVNAGFGMLFLNASIAFILNVASVCLIGKTSGLVMTLTGIFKSILLVVASVLIWSTQITFLQTVGYIIALAGLTYYSLGYDQLASLGAATLAWMNEFLSVNGGNGAMRSKRVVVVGLSSLVAVMVVLELTMSERGRRMLASSWHDRHGRHGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAA2</accession>
    <name>A0A2T4CAA2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAA2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="56" mass="6112" checksum="92CCC8E1F7F7DFF6" modified="2018-07-18" version="1">MVCRRQQSSLCAERLPPRPMTRSIGPLRRSDTVSGVEDGPSSNHVAPLGIERLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAG2</accession>
    <name>A0A2T4CAG2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1329507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAG2"/>
    <dbReference type="STRING" id="983965.A0A2T4CAG2"/>
    <dbReference type="OrthoDB" id="5427070at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="15062" checksum="CC603DE305A62961" modified="2018-07-18" version="1">MGDTLAGIKTLVIPAVISLILFLLLTFVVVPVWRRYRSRYSQYLPLDAISEHTTSLRYRITGRLLRIASLPFTWRRDGLVASSGAAGGARARLSDRDLEEGEELEDIDDDIAQVLEAIARSRRPDHTRRLSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB31</accession>
    <name>A0A2T4CB31_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1429649</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB31"/>
    <dbReference type="STRING" id="983965.A0A2T4CB31"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="59"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="240"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB78750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="402" mass="45636" checksum="2DEB674DC9E3EC20" modified="2018-07-18" version="1">MAEGAGGIDRKADERMEFSTSKEVTVHPTFEAMSLKENLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISMLQVIDTAVRETQALVLSPTRELATQIQSVVMALGDYMNVQCHACIGGTNVGEDIRKLDYGQHIVSGTPGRVADMIRRRHLRTRHIKMLILDEADELLNKGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRILVKRDELTLEGLKQYFIAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGDMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTTEDVRILRDIELYYSTQIDEMPMNVADLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC19</accession>
    <name>A0A2T4CC19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1370715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC19"/>
    <dbReference type="STRING" id="983965.A0A2T4CC19"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000131">
        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="285" mass="31646" checksum="685E0797333F1176" modified="2018-07-18" version="1">MAPRTDFPPVRACLFDMDGLLLDTEDIYTDCINVILREHSQTRTELSWEIKAKLQGRPGPAATEILLEWAGLKLTADEYKARIVALHEERFPTTKPLPGVRELLANLIKTQGHGIDGSAQDKATKPVHIALATSSHLANFKLKTDHLTDLFSVFPDHRRVLGDDARLAHGRGKPLPDIFLLALDVINASLPEGEEPIKPEECLVFEDSVPGVEAGRRAGMRVIWCPHKELKKLYAGREAEVLAGRMGEAGEVDMHQVGELDDGWGEYLASLEDFPYEKYGIVVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCG9</accession>
    <name>A0A2T4CCG9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1327062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCG9"/>
    <dbReference type="STRING" id="983965.A0A2T4CCG9"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015619779" description="Glucoamylase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="524"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB79245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="632" mass="67428" checksum="AD524F7DEDFD8720" modified="2018-07-18" version="1">MHVLSTAVLLGSVAVQKVLGRPGSSGLSDVTKRSVDDFISTETPIALNNLLCNVGPDGCRAFGTSAGAVIASPSTIDPDYYYMWTRDSALVFKNLVDRFTETYDAGLQRRIEQYITAQVTLQGLSNPSGSLTDGSGLGEPKFELTLKPFTGNWGRPQRDGPALRAIALIGYSKWLINNNYQSTVSNVIWPIVRNDLNYVAQYWNQTGFDLWEEVNGSSFFTMANQHRALVEGATLAATLGQSGSTYSSVAPQILCFLQRFWVSSGGYVDSNINTNEGRTGKDVNSVLTSIHTFDPNLGCDAATFQPCSDKALSNLKVVVDSFRSIYGVNKGIPAGAAVAIGRYAEDVYFNGNPWYLATFAAAEQLYDAIYVWKKTGSITVTATSLAFFQELVPGVAAGTYASSSSTFTNIINAVSTYADGFLSEAAKYVPADGSLAEQFDRNSGTPLSALHLTWSYASFLTATARRAGIVPPSWANSSASTIPSTCSGASVVGSYSRPTATSFPPSQTPKPGVPSGTPYTPLPCATPTSVAVTFHELVSTQFGQTVKVAGNAPALGNWSASAAVALDAINYADNHPLWIGTVDLEAGDVVEYKYINVGQDGSVTWESDPNHTYTVPAVACVTQVVKEDTWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCN5</accession>
    <name>A0A2T4CCN5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1166862</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCN5"/>
    <dbReference type="STRING" id="983965.A0A2T4CCN5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="64"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PTB79329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="313" mass="34264" checksum="CA954CE9F9546530" modified="2018-07-18" version="1">MAAKPEDGLLARQYIDYIYVPAGLLIVGTAIVKMDWTPYAVLLAIALGVWNYYSFQIKKVLKPDVFQEFPLQEKTVISHNVAIYRFKLPTPRSILGLPIGQHISIGAHLPQPDGTVKEIVRSYTPISGDHQPGFVDLLIKSYPQGNISKHMASLQVGQTIRVRGPKGAFVYTPNMVRHFGMVAGGTGITPMLQVIRAIVRGRAAGDKTEVDLIFANVTAQDILLKEDLDALAKEDSGIRIHYVLDKPPEGWTGGVGFVTAEMINNWLPKPAPDVKILLCGPPPMISGLKKATESLGFAKARPVSKLEDQVFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCP0</accession>
    <name>A0A2T4CCP0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1326341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CCP0"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1266"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1304"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1345"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1362"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1468" mass="163185" checksum="E5B995787918AE73" modified="2018-07-18" version="1">MESEPEAEPEPEAEEQEAEEEYEGKHRRLRFNEELSWRPAKPIPSATLLARLERLSKELADFEQGEVDLISLRGVADKLAHRNLLQHKDRGVKAYTACCLVDILRLFVPDAPFTDDQLKMMFGLFIKDILPSLQDPTNPYNSQHKYVLMSLTDVKSILLLTEIHGSDDLLLRLFNSTFDGVSANAKAPAEEQVAKDVEIHLTEMLIQLIDESPGSVPASVIDAIISQFLRAAPPGGGRSKEQNDKQSTLLLKTEPPAYVMAKAICNGCADKMARYVSQYFSDVILNASGFATAGNGARHGDDSEEEDAHAGPSEADLKSLRQAHLLIRELWRAAPAVLQNVIPQLDAELSADNVHLRLIATETFGDMISGIGAAGPPPPPVLDPAAYPPIKLMDDAPPVAVEANVLTKPYSPQSFAQSHAATYRNFVGRKNDKTGTIRTAWVTAIGYILSTSAGGIGLSTQEESELVRALVDKLNDSEEKVRLAAVKAIELFDFRDIILKLGILGGVDKEGSVFASLADRCRDRKPAVRVEAMVLLGKLWAVGAGEIADGQEAVTACLAGVPSRIINAFYANDPDLNVLLDRVMFECLIPLKYPLIKGKGAKTAAASSQGKAAVGQADQDKIRAERILLMLKSLDNAAQKAFFAMQARQPQFAKGLEIFIQQCEAYNGGVIEANEEKVKAGLAKTMQWFGAYFPDPLKVRADLQKFVKLNERRCYQLIKYAIESESDFKTVRRAIAELITKISATSAASCLDTLIPLLYRSSCLMFNRSHLATIMDYSKSDKNGFAAVAHQVLNDISQRNPDIFKAHAEELRKELIQKAPTESTKSHDAGVVDILKAYSSYAKRYPEDINLDRSFTQTLINYALYGVPIKTPKYAVNILLAKNDDRSKVTATNLLRKVMANFKYEAPHLLNKLATISQLERLAPTVTVDSDQAINDMTIKQILREVRTQATEKDPSWVDDADMDEEIQAKCLSIRILVNQALATSADADAEERVKPVFKLLKTLIVSEGEFSKVKDTPKHHKKRLRLMAGLMILKLCTFKKYDDQFDHASFNKLAELVQDTELQVRRRFMDKLQNYLTRGKLRARFLTILFLTAFEPFPELKNRVETWLRSRSRYYAENGQQIMEALMGRLIPLLAHHPDYTSDPADLVDFANYFLFYLGAVATEQNISLIYKYAERVKQTRDGVDPEKSENLYALSDLAQTLVRKYQERKNWSFQAWPGKVGLPTGLYTALPSSEVAQHIAKKQYIPDELDEKLDDLIRAMDRKKKRKSLHETADHPAKRSKTQLKTVIREKPGPKAKSAKAPGKKIAKPKAAPKAKKAAPAVPEGERRRSGRAHAISTYTERGDEEDEEEMLEGVAEWEYGNDDEDEDGASEQEESGNEDEEQGPESDKAEREEAREEEEDEESEPEPAPRSNGRKAAAAAAASKGKGKTPAVKASVLAKTKQPARATRGRPPKHASDMDVDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCT6</accession>
    <name>A0A2T4CCT6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1398626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCT6"/>
    <dbReference type="STRING" id="983965.A0A2T4CCT6"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="51" mass="6199" checksum="1BD07BEEA150FC0D" modified="2018-07-18" version="1">MASHKTFRTKQKLAKAQKQNRPVPQWIRLRTGNTIRYNAKRRHWRKTKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCT7</accession>
    <name>A0A2T4CCT7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1327044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCT7"/>
    <dbReference type="STRING" id="983965.A0A2T4CCT7"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB79391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="36004" checksum="1561034F5AD664B1" modified="2018-07-18" version="1">MATGGLFGAKPAGTGLFGSPATPTPQTGTGGGLFGGATNTSSTTGTTGGGLFGSTTPAQPASGTTTGGLFGAKPAATTTTTPAATGGGLFGNTTGTQQTTTGGGLFGNTATAQPSTGTTGGGLFGSAATTTQQQQQQPASGGLFGNTASTQQTGGGLFGSTPASTTTGGGLLGQTQAQTKPAGGLFGGTTTQTAPATTQTAAVQVNYDNLRPRSRFDDLAQPIQNEIALIDKGIQRVIKMRDEIGEFMPQHEKDIDQLGRDVQFVESKFKTVQDALNRDILTVKALQDMTKKDQIRSLRDSSSSAPVQDQLGQVLAALREMGSAIVAQAAQIADTRERLSRLQSGFLDNGLYAGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDJ8</accession>
    <name>A0A2T4CDJ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_17479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDJ8"/>
    <dbReference type="STRING" id="983965.A0A2T4CDJ8"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="485" mass="53864" checksum="A13BEF3DC0AE94E7" modified="2018-07-18" version="1">MPKATTPTATRPGRRHNPLEDDVLATGILRNKPTKRKGKDVDESEETFVDSKASKNILRIGRELMEEENADKPVQKTTVDNFGFDSRFGEEDGEQKGYDDEEAWGDEDEMVEDVEVDPQDLDTYRKFMGDEEEDDLLKHGWDLKGSGEAQGESVNLADLILEKIAAHEAAQAGGDNVRPPDDDYELPPKVVEVYTKIGEILSRYKSGPLPKPFKILPTIPHWEDIIDITRPENWTPNACYQATRIFVAAKPGVVQRFLEMVVLEKVREDIYETKKLNVHLFNSLKKALYKPAAFFKGFLFPLIGSGTCTLREAHIISAVLARVSIPVLHSAAAIKGLCDIAAQEVSQGSEGGGATNIFIKTLLEKKYALPYQAIDALVFHFLRFRAEDPAAARAGDNMTVVMSGPDYRAKLPVIWHQSLLAFAQRYKGDITEDQREALLDLLLTHGHSAIGPEVRRELLAGRGRGVPLEPQGAALDGDDTMDMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDT6</accession>
    <name>A0A2T4CDT6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1178410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDT6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="18517" checksum="03B63275A1C03B39" modified="2018-07-18" version="1">MRCAPFRGCYNVEHVRPWCFVRRRMCPSYPNPYQYPYRHPNVQVETGKRGRRGVLVPAGCGERVSAWRRRGAPFVGPKQKRAIPSIITRMAARITTHQTSPHAAAVVSQGELSLGRRGLLCMHYPVWGTNAGDHRLWPLPQGTHTGGGEWGPASRLLSRRLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEE6</accession>
    <name>A0A2T4CEE6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1388328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CEE6"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF69">
        <property type="entry name" value="HISTIDINE KINASE G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="619"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1148"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1287" mass="141812" checksum="4DE46376E1D89A44" modified="2018-07-18" version="1">MAEIRYDPTLLSTTKFNNSGVALPSSELMPSQDLVLTALAQLAVFQTGTERAFISLFDVDHQYFVAEATRTLLTSPDDVDLGLWMVGTAIPRSQSTCEYTLLESDRLDKARESAAVPDLGPAQFDVCENEGDANQLPCLVVPDLATDPRFKTKPYCRPGGGHRFYASVPIRTQRGINIGVLCVVSPEPKRRWSDHYTNLMRRLSMAIMDHLEANFSKVAYRRSERMIRGLGFFVAGKATESSWASVAGRETFTETPDALLLARQGLMGDAENAKEQRQPASEATARSTPASERSLSPDGERLDPSFGHDRSGKPAAETKWADSFVPGPNPVIDTFSEAANIIRESLETDGCLFLDATPGSFGEYDSRSGGARKGRSSSHPSFRDVETTSDDEDDESGSDNENDDGVPEPQPGDADADSGAATKGTADAEPKADKWPSCQVLGYSATESRRMKFEDGSLRRISMPQKFLAKLLHRYPKGHIFNFGVNGELQSSDSSDDDGWLTDLTQDAASPLQPEPQQQSQDDASQTKRHRRPWARHNEGKVIQQVFPKARSVAFVPVWDPRKQRWCAGGFVYTLTPTRIFTVGGELNFLRAVSILAIAETLRLKTFAANQAKSDALSSLSHELRSPLHGAVLGIELLRDTELTVFQGNIAHTIEICCRTLVDTVDHLLDYSKVNRFIQTRRKGGQTSEPRGLRPGTARSVEEGMLSLYKHIRLDGIVEEVMDGVYAGFNFMHMALQLAKHKTSAHSSDWTAMRRLDAMQAMEELGSNGKIALGEVTVFLEIDHEFNWRFYTQPGAIRRIVMNLLGNSLKYTQRGSIKVRLTQSKPKRKSSADAIVHITVSDTGKGIGEDYLRNDLFKPFSQEDHLAPGTGLGLSFVKQITSQLRGRVTVDSQVNVGTIVRVSLPLMQTVTPPDGTPLLAENEGDLDKHVAEASGLRVRLMGFDIGKRGKRRMLDGSSTELLTEVERICHDWLGLDIITEAEAKEKEPDCVIWIEDRLADSPLENLMQGPPCVVLCKNTLVAYKSAAQFERVKAHRIFEFVAQPLAPRKVAKAVAMAFKRGREMKTAPLSPVNQRQEFLPVVPDILSTVKTQLPAPAPRLQALQDLLSENSPPKNATARPDKADDPDVGLGIFDTTIAAAHDVAAGPEFLLVEDNSINLDILSIYMKKLGRPYHTATNGAEALSAYKANPKHCKYIFMDVSMPIMDGFEATRRIRAYERDNHIEPAIIFALTGLASESAQQEAFGSGVDLFLTKPVKLKELGMILRSRGLLPEEPLVVVTKNGTHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEL6</accession>
    <name>A0A2T4CEL6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1435741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEL6"/>
    <dbReference type="STRING" id="983965.A0A2T4CEL6"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="199"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="665" mass="74899" checksum="92CDD70F72218FB2" modified="2018-07-18" version="1">MDPLSVPVMLSSDALAMSESVSFAIPELSDSEYFTEVLRLPPGKSEAEADRELVARANAAGIAATLPSVASKRHPASSCSVSSFETQQDRTFSNASTGSTSTALTPHSSIFGPSSSLFDTGSGTRGVSASSLTFSHYERLIAIVDSGSTQHQSPRPPPTPIANGSSSQSVVSVASKKSHRANLRDRLRWRRKTVEPVEVKIPCFSCKKEFGAESGTLYKLSCGHMRCVDCIQGMVDQAVQHESQMPPRCCSQPLAAPLVRTILTQDAQVTFLLAVLKLSTPAEERVFCPDPACGHFIPPNDAHDAKHPFDLTCFKCNGRVCAICKGAAHSVGENCPQDWELAVLQKKQQQQHDIECWKRCYECRALVEMAAESPYMTCRCKARFCSVCAAIWDPTTGCPNLCSFEEELRRRRQMEDAAPCEEELQLRANSAIQQLGEQQQKELRRFLEYKSHSKDALQTRHLIQEVAVEEKYDCQEEKLRERHERAWSQQEDRHVAAEMGLLETLQQDELNIHLRLKHMEAYCNGVGQNPNTMSPGRVVTERDMAELRRQYYLRDGMDRTRESKINLMRERQAVKMEELRVKQAEEYALLTDARQEALDRLEAQFVQEESLFNAVFASRQSQLQSRWVLAIEVLCKELEERNPGQAYRRIATPRWPDERTLDVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEX2</accession>
    <name>A0A2T4CEX2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1111463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEX2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="197" mass="21517" checksum="36E35E04627BA486" modified="2018-07-18" version="1">MRARRASLTCRQGTGLPYTRPLRESTGALAGTTGPPGPLDDHSSPCFSRQLTLRLGLHSPLGGTTRRGCLRRTNYPPPFLVTRQRAYIYSAQVWYGIALACMRAHVASEAESAVGWWHLALQWASGAPRPTSAELLPGSSINPASKNIPTWRVRAMHPPPIMPAQEHTAEVPTPVLLHNQQDGIVLHPQRALATRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFD3</accession>
    <name>A0A2T4CFD3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1388579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFD3"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28104" checksum="F87A7D0B78DFAFA8" modified="2018-07-18" version="1">MSSKIPPLLEPYLGLPEEASLIVLTNVMGATSNWLILRYLCSILQGRGVGGDGSGVESGVVLVSFMRDLAFWREGASRLGLDLDGLSRAGKFSFVDGLTGLLSGGQGSESTKDKGRVIKSGKLEDVRRGIEAAIGDVRPSAKVLIVDQLDELLAISGEEDATALALEGMLFSLRERVHATILAFSADDALLRAQNTSLERSHAALVLAQAHAADLVLSLRMLDTGVAKDVSGVVRIAVRKEEGEGAEYLYHVGADGNVKVFERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGG1</accession>
    <name>A0A2T4CGG1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1419191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGG1"/>
    <dbReference type="STRING" id="983965.A0A2T4CGG1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="402"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB80640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="758" mass="87868" checksum="F19DBEE7F2372714" modified="2018-07-18" version="1">MPPVPNREDIKATWKYLEDGITRIMTDLEQGMDMQMYMGVYTAVHNFCTSQKAVGLSGPTMTTSHRGAHLLGEDLYNHLIKYLQRHLADLVQSSKSHTDEALLTFYIKEWNRYTIAAKYIHHLFQYLNRHWVKREIDEGKKNIYDVYTLHLVQWRKVLFEQVSDKVMDAVLKLVEKQRNGETIEYGQIKQVVDSFVSLGLDEADPSKSTLDVYRFHFERPFLAATKEFYQAESKQFIAENTVVEYMKKAEARLAEEEERVNMYLHQDIAIPLKRTCNQALIADHSLPLREEFQVLLDNDREEDMARMYSLLSRIPDGLDPLRTRFETHVRKAGLAAVQKVQSSEGDKLEPKVYVDALLEIHTQYQGLVKRAFNDEPEFTRSLDNACREFVNRNEVCKSGSNKSPELLAKYTDVLLRKSTTSIEEADLERTLSQIMTVFKYIEDKDVFQKFYSRMLARRLVHSNSSSDDAETSMISKLKEACGFEYTNKLQRMFQDMQISKDLNKEFREHLETVGNARSVDSTFSILGTGFWPLTPPSTHFDPPPEIASEIERFVRFYKHKHDGRKLTWLWHLCKGEIKAGYCKNSKTPYTFQVSIYQMAILLLFNEKDSYVYEDICTATQLSTEVLDQALAVILKAKVLLMEGGDKPGPGKVFNLNYDFKSKKIRVNLNLGGIKEAKQEEVETNKTIEEDRKLVLQSAIVRIMKARKKMKHGLLVSETINQIRSRFVPKVADIKKCIEILLDKEYLERLDDDELGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGJ1</accession>
    <name>A0A2T4CGJ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="983965.A0A2T4CGJ1"/>
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    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
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        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140361">
        <property type="entry name" value="MIT domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="72"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="250" mass="26485" checksum="5D938B646A131CC6" modified="2018-07-18" version="1">MEASPLTKAHDHARAAAVATRQSADTTVAISEHTLAAGEFANAASLTSSVEALRTLKLLEEHHRKLAEILKLPPEQVPHARADDGGGEKAAATTSEKASSDGGGDAVAGDALHAAAAKAQQQQPPGLASQRRYVPREMSSSIASNLASARGIRSNKDRGQPLSPSVSNDQAPGNLDPQAKRDHYDDNDNDNDDDETSAPPPVPSVGPARRRRRPDRQYREKWETLKAGAKARRGGQSTTGESVEDARSQV</sequence>
</entry>
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    <name>A0A2T4CGM9_TRILO</name>
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            <fullName evidence="4">3-isopropylmalate dehydratase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">M440DRAFT_1325474</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13748" checksum="F4FC3A85CE5948E4" modified="2018-07-18" version="1">MLPIQISNKEHLDAIAAEARAGREIEIDLPNQLIKNAAGETICSFDVEEFRKHCLVNGLDDIGLTMQLNDKIVEFEKKRSIHTPWLDGTAYLKRGKDGRLAAKAVPVPKTNRGEEKKEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGW3</accession>
    <name>A0A2T4CGW3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial F1F0 ATP synthase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
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            <taxon>Hypocreaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11204" checksum="AB1E5889D9A1174B" modified="2018-07-18" version="1">MSFVTRRALSTLIPPKIASPKAIGAAPDALRMQRVVSFYEKLPRGAAPEVKAKGLLGRYQAKYFGKNASATPIIHALVFLIGIGYAQNYYFHLRHHKNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH87</accession>
    <name>A0A2T4CH87_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1459279</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CH87"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="239"/>
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        </location>
    </feature>
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            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="423" mass="46573" checksum="65E2BD542DC96DC2" modified="2018-07-18" version="1">MRPSGEIRSQTATPPSPSYMTKDEFASYLANLRNKPVVRPGGARPLPPSSRPQVNRNSLSHISFDASTAPGRDSPSPAPHVGHQRSQSFTPSLVAGSMVSSRLSTISSRSRDYYPSRPTPPPVKPDDVVPTASYMERGRRWMEREEASSLRDAMEEMDLRESRKNTPDIDPAAEDEETRIYNAALNEAAELVWEHQNGVKPRPPEGAYRYRSHLRKDSYAHARAAALARGEDSPGANKSNRNSYASFRSSSANSSDEDNGARLNGSPEKKGAQAEESPTNKNKSYGGVGGRFTGGRRSSMKRNISGEVERPFSGDQIWEEPEAQPGEGRTTSTPPNGDSPVSLHQKPSNAMGRVPYQRNQGETSPTKRLERIEIHRNPPTRSRTAPYQVNTPGGFDDGQIFPKETASGAIILCTKCRQRELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIQ6</accession>
    <name>A0A2T4CIQ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">M440DRAFT_1014581</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIQ6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="61" mass="6822" checksum="7F2F99F51904E20B" modified="2018-07-18" version="1">MYQRCHVSLGLPSSVTLFCTTVGQLVSRSVMTSCPQSRPRSTPMKQELMHHCPSPIFNLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ19</accession>
    <name>A0A2T4CJ19_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MutS protein homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1396670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ19"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ19"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="727" mass="79774" checksum="3B7FABA2647B22A2" modified="2018-07-18" version="1">MAPLSQASEKKQKSLTAFFTPKAVNGTASSSQPTVSSSPIPVKESNLPSRKRPLEKDGDKANGTAEKALKRAKGDDAIIDGESSFFRKDSSATAAASIRSPTSARAQRYRYDESNSQEEAGNNSDDADTRRRNEELHRKFVKKLGHPDALSWGLKAQDSGVTGDDEDADAEPEEEEAPVVSKAKKKGAKTGKLTPMEVQFLDIKRKHMDTLLIVEVGYKFRFFGEDARVAAKELGIVCIPGKMRYDEHPSEAHWDRFASASIPVHRLPVHAKRLVAAGHKVGVVRQIETAALKKAGDNRNAPFVRKLTNLYTKGTYVDENGELDSQDASVPSGGYLLCITETASKGAGTDENVNVGILAVQPATGDIIYDNFEDGFMRSEIETRLLHISPCEFLIVGDITKGTDKLIQHLSGSSTNVFGDRARVERVPKSKTMAAEAYSHVTQFYADQVKEASDNETASALLDKVLKLPEAITICLSAMITHLQEYGLEHIFGLTKYFQSFSTRSHMLINGTTLESLEVYRNSTDHSQKGSLFWALTLCDAIHTRAGARDNLFAGESTFMVEVSETARILRSATPRSLVILDELGRGTSTHDGAAIAQAVLHHVVTETRCLTLFITHYQNLARIADGLPGVTNVHMKFNADKGPDGEEEITFLYEVGEGIAHRSYGLNVARLARIPKKVLDVAAEKSKQLENEMRRRRLQGACRTLAHVLESGPDQLDHLISSIEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ81</accession>
    <name>A0A2T4CJ81_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1387977</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ81"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ81"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="16">
        <location>
            <begin position="481"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="205"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="378"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="544"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="300"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB81593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="703" mass="69639" checksum="FB274EC6E6768E75" modified="2018-07-18" version="1">MSFSFGTPSSSGAAPNNTTSTAPAGGGLFGNAAASSGTPKFSFGNTTTPATNPPGSLFGGQNNAAQKPASGGLFGSAAASSSSTPTTSAGGLFGGASTTPVTGGLFGGTSTATTSSGGGLFGGATTSTAPSTGGLFGNKDASTPTATGGLFGGDANKTPTATPTPAAGGLFANTGSSLFGNKASTPTTPATETTTPAKPLFAMASTTPAGAPPPNAAKTAGSNLFGTNTSTTPASGLFGNTSKPATTSASTSQPATTTTSGSGLFGSGTQSSTSGLFGAAKPAATSSTAPSSGGLFGNKTATTSAQSGSSTPATTPAAGTTSSLFGTKPATTTTSTTPAATSAGGLFGTTPAATTAPASGSTPATAAAGGLFGLKPAGTTATTTSSSTTPATTATSGNLFGTAPKASTATTDKPATSLFGTTATTKPATTASTTATTTTAAPASTTTTAGGLFGAKPAGDKDAAKPAAQTSTINPLGASTTGPPSQMARLKNKTMEDIVTRWASDLSKYQKQFKEQATIVSNWDRNLVDNGEKIQKLYLETFEAERASHEIERQLAAVESQQEELEAWLNRYESEVQDMFAKQMGPGEQLGGPDQERERTYKLAEKLTQQLDEKSRDLSKMVKEINDISGTLSKGTKAEDPLSQIVRVLNSHLTQLQWIDANSSALQAKVAAAQKSSSNLGSHYGSGESDVAESFYRSYMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJG7</accession>
    <name>A0A2T4CJG7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1467143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJG7"/>
    <dbReference type="STRING" id="983965.A0A2T4CJG7"/>
    <dbReference type="OrthoDB" id="5426988at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21387" checksum="984446FF43FAFAA8" modified="2018-07-18" version="1">MAAPLIWINAFPGTGKLTIAKAIKALDESVIVIDNHQLIDPVASAIPRDDLSYQAERKREREGAFQKYVYDRATASQTVVFTDFQSDNELGRSVAKEYLMAAKKARRPFMPVYLGCDVKVNIERAMSRDRMSGTTTKLTDAALLRDMRSRYKLFEFDDQDGSTWIDTTNKEPEGVAKMILGRSRVVSEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK39</accession>
    <name>A0A2T4CK39_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_357986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK39"/>
    <dbReference type="STRING" id="983965.A0A2T4CK39"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="284"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123915" checksum="14BCA4663FCB277D" modified="2018-07-18" version="1">MSGLEALSLVCSIMQVISFTKEVLTVCKDVYEGRTTADSQMGQDAATIKELLDEMNRTAGSAPQQTKEERELHAIAQMCSKAAEELEFGIQRVTKNQKPGSPMGALRAGIRSFSGKRKITSLYDQFCKHQKSLETHILVRLCTKSEAIMLQGRDDFNQLSETMKHFVSQMAAGHTDMASLVTRDGTQTRQQIQQSEDRLKQEINDVHTEAVSEAKRERLLRSLKYESMNSRRTGLKPAHEATYLSIFDSLDAEGSDAEGSDAEGSDAEGSDEEPYDDKAAIAWKDFITWLQSEKQVFWIQGKPGSGKSTLMKFILQHEKTQRGLDRWRPNALLVSHFFWKPGDLLQKNLRGLLCSLNHQLLSSDHALVGHVLSEHTFAREKDTIGDWEIAQLDSIFYKILGQCKRSVFFLIDGLDEVTDIDEVLRFLESLTSQKNVKLCISSRGEDVFHQKFSEYDGLKLEDLTWDDMSQFALAGIPDSFGKYPADFLGDLRDLLVEKAEGVFLWLVLALESVKRGLRNNDKQDEIHLRLRQLPSKLEELYADMWDRLGDDKAIYQREAARYFALLVTNQALREDYQQQFHLSPPDSHLNPFLLMLDKNETLRGEMLDQSYEPSISKIEKECGDIALGVPIKTAGFLVTRKAAVYSMLLRLQYESLKEHLELSVEFLHRTLFDFFLESEVGRAILAQGQTDCIKLELATIFVCQLRTVHCCDITFWRMGAGGTLHYCMWILGQALAQGSASERAMVVDLLHHLESLFAAGWLSWDFRPDWYPRPPFDLLLLIDAAFKPLLRSRIESRGSSHATILLREATRAYIVGGIYHWRLTWSPLKLEKWLTTLGGDITSADICLYETHHDLGRSFRFDVQFAPYESTLSLAIKRCLKGALEDWDVAYLSMRLLSAVSKRAPDLNERTSFAFSVARAKGRRRVYCLRVDQIGFEHAYRSEGSESDWEERTTIISEVNLRYLIEILFKATPSGGKNTTPEVIRAQKLLEAEDSKPYIRPRFLTEKHGMQGPMLSKRCYRFIDQDLDIMADSTITEATADDFAKYDITPEKLAGYRSRCERVPLSALAVLADERLGVCRIADMGIKPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPC8</accession>
    <name>A0A2T4BPC8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1426776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPC8"/>
    <dbReference type="STRING" id="983965.A0A2T4BPC8"/>
    <dbReference type="OrthoDB" id="3930719at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="218" mass="24361" checksum="A6EFB83E1F41FB03" modified="2018-07-18" version="1">MSDQPAQASQPQRLPYKGSCHCGAIRYIVFLRVPPPSYANSAPPPKRGVQRIYRCNCTICHKIGFLHLRPTSEFDDFFLLSPLDPLESLGDYLCNNKRLHYLFCKTCAVRCFTFQGEGEIVDVTLPEVLALAGGGSSGTEQDGVSVKAWRPKKIELIDGIPDGGSYLSVNGQTIEPGQEGFDLREWSERKAIMYLDYLADEKDRLVERCERPHVGGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPK0</accession>
    <name>A0A2T4BPK0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1466377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPK0"/>
    <dbReference type="STRING" id="983965.A0A2T4BPK0"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="142" mass="16491" checksum="62D3CADE7A8C96C1" modified="2018-07-18" version="1">MAITDSPLPQPQQLLCLTITAYRKPGLSESAYREYMTKTHAPLVSGLMKEYGIVRYNMTHNDSTSRPLLFQLYDPEFSKLSDYDCIVQFVFRKMEDFLRMKADPRFLEKVAPDHKNFADTSRSTMTIGYFEEFLDNGELVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPL6</accession>
    <name>A0A2T4BPL6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1344409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPL6"/>
    <dbReference type="OrthoDB" id="4882991at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38486" checksum="DD1AB5DC7184610F" modified="2018-07-18" version="1">MAPFGVSDTDIHILLLSFIATGLLYEYTHAYLDRKLPKWDCLPKTLRNRMCIEIACIPVRIGLVYFSLPSVIWAFTPASNWTAVDTQRSLIACSMMTGAYLFDLMIYREDVFGVLHHCMGPALLLWTRLCFSSFTSADALVSRSLMMFIFFGAATGGVFASAGVFVLRVGKKYLKRDILHRYFALCVAGLTATTVLSCYLNVLYFLHTWDQAYAYFGLALPLPIVWETFECYLQWRWLLRFYSIEDQLRRGDRRSKDYSDKSDHSRRVSDYTQELPSAFPRGTLSVLRVLVCQWVLLLCCLYFKFMREVYFRWSTPSAQAAYQMEVASNNSVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPM2</accession>
    <name>A0A2T4BPM2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPM2"/>
    <dbReference type="STRING" id="983965.A0A2T4BPM2"/>
    <dbReference type="OrthoDB" id="2149705at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="589" mass="64587" checksum="BAAD8E89D44C1DDB" modified="2018-07-18" version="1">MPSKRESRDAARQGRTYRSTAPAKQVQFPIRRSRVRGPGNGIQKREKASLKQQTLTQMAFVSSFSDEAPLMDDDSDEAASASDGMACDDDDKPTASHRIPEAELEEEEPRTLSGRPTRGPVRGTSPVIQDSYASLDGSFPDGELVEASPPQHRPSRGRDAAVSPRRRGRMGSLDAVKASPRRRAHWSRYSAGPKTPEQSSQANDTSPLVKYADDREIPDSDEEDEDLDLQEVGPALHQDTFATGHETQFVLEELASLEYSQLDGQAAANDQLPTSISRPSALASPGSAAISKLAQPPTEAPECLPTPAETASQLPSTPPFPTAASQSRVPAESSQSQVCHDQGFESQRVPLHVLQSFTPVSARTDILLPTPPDILKSIADGSEATLRLTYRVPEDVRRFWLFDHETLRYMACVQPGTPRGFLDWEYSVDQVYELNNPVEEHDMQEEGWVTGQVRRYIYLPPAIVGQLLWNLRCATFARGASRRGEDDDENHESRDGECNGDAETQDIRLPNPLDTDHRARIPVTSSQPAIYTENRTTPRDVDPPSSLFFEDHGSSATTVPATDGAALGSSPLLTKSQMLPDSLVSDDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPQ9</accession>
    <name>A0A2T4BPQ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1386840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPQ9"/>
    <dbReference type="OrthoDB" id="4894171at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="250" mass="28935" checksum="F2FFBA6578DBB4B5" modified="2018-07-18" version="1">MLFWSRTSYAPLRDDGKEEVPRSHQPACSIFWPICSAVLLAICLVLSLLLQQRSRAKCGSEPYLTSSKTDFEPAVPHIQYHQVQFGGIVLSEGSFKITGGASTRPYVGTSYHEIDEVWNEILEKRWFNLTAEEKQSAFGDKADEYLDFVQLDAFHLLHCINHLRKVIDAEFYYPEGRPPLRIHTDHCLDVLRESVQCHGDLTLIPYRPDKNSAYYYSDSIQTHTCRNFDVLRRWLSDTREPFSIDPFKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ23</accession>
    <name>A0A2T4BQ23_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sin3 associated polypeptide p18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1344194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ23"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ23"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24973" checksum="FB61247266BACE14" modified="2018-07-18" version="1">MLTSRGGDAHDVSPFLVRLFYKTGSFYRPEEFASPSLPPHVPIYTWSSCTLHELALELAAAKPSAIPTPAVGTRLSFQLVCPDLRGTSAIHTAQPKFAVKDLGSVVIGEGNPSADDGDDGPDTLMRDDATKDKTLADWRFVVGDYISCAVLPPLSDGSVAPPSAARRASLSSGRDSRGGGFKGGFHGRDSNFGRGSGRQGRPTGWREGRIPSGEWRRGEELPVGPPGASRGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ64</accession>
    <name>A0A2T4BQ64_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1442587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ64"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ64"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="580" mass="65280" checksum="3AEFE28F0FADB2F1" modified="2018-07-18" version="1">MAPARGTAFYPRKRANTACQVCRARKTKCDNKKPACSYCVSVGATCIQSPVDLSSFDPASLKILDRIDELERLLRHAVPIPGPEAAAPPSVSGRGHPDDNRDIISLLPQRVDHILQWPVFQNSGSHHHSPASYRAPPDAITTPPSGSASLAGLIDMDSHRIYRLLDNFFLHIHCKNPILDEVLARRMVINAFLDGIDWSPASCLALIICALGCIATPFGPSGETKLGTQTYNDSQIFFQAAQKRIGILLVRSDIVGAQCLFLSGIYLMMVFQPVYAWRFFSQALAACQHFPFLARAQNLNASLDSMEMGRQDTQEQAVYWSAWKSERELRQELDLPDFDILHSGSTLYPPFFPAPPVAPAESPDGPDSETQRARAAWLFYLAEISLRRLTSRLSREALDLRQRYTSDTVLLDMLLDMMPEYEAQIREWSDSLPADLSIHTPVEEDGICRSVLRGRMINLFEQIYWPFVMASISAHTARRPVKPAVAEFARRGLETHMHQVHVNKPGFHHRHHGSMFMIRACTRSSLVLLAAARAGCAMPTDWEDSVYKTVGMLAYWEDEDRDLIHWRSTLERELALTRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQD2</accession>
    <name>A0A2T4BQD2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_215830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQD2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015647632" evidence="1">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="116" mass="13307" checksum="D396BE13371434C6" modified="2018-07-18" version="1">MPMPCHVVNPSCFVLLLLLLLRPSSVSPSPRFLQRKKDPCVGDWHPLTVTREGEVLQKNGFLQRQREHYGIWEHGPRLVTGKDIYGVQRPFGELGWNWHRIHGSRCDNDGASPIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQJ5</accession>
    <name>A0A2T4BQJ5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1343838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQJ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BQJ5"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="413" mass="46727" checksum="8FC593CE010409E1" modified="2018-07-18" version="1">MAAPTAAARYVQRVASQVRLRSARAPRGQLTLNRWASTASGSRRGHASFGGSSSAAVWLAAAAIGVTAPLAYSLSTAESTKLDVSTLAEKDEQKKREAAVTEESPMRLRMEKFIKEQQQIIVKELERIDGKKFRKDEWTRPNGGGGITCVLQEGNVFEKAGVGVSVVYGSLPKPAIMKMRENHKNLDPNVESLEFFAAGLSMVLHPSNPMAPTVHLNYRYFETANPDGSSQAWWFGGGCDLTPSYLFDEDAIHFHKTIKEACDSHDKTYYPRFKKWCDKYFFNKHRGECRGVGGIFFDDLDETERDQENTFAFVQDCLKAFLPSYVPILEKRKDMPFDAKEKEWQQIRRGKYVEFNLVHDRGTAFGLNTPGSRVESILMSLPLTASWKYMYEPEPKSREQRLVDVLKEPKEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQY4</accession>
    <name>A0A2T4BQY4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_208092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQY4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="13712" checksum="259943A101B05525" modified="2018-07-18" version="1">MARQSCTRRSSAQILVYHATHAIQWTSSILLERAMQHLTLKRIQHHQLSLVVPLTTWSVEGSAWATSMCLDQSILAWHQLDGRATRCSRHRLAASFQMWHVSAAALRSRRIRRLSIGQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRB7</accession>
    <name>A0A2T4BRB7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1395340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRB7"/>
    <dbReference type="STRING" id="983965.A0A2T4BRB7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="543" mass="59998" checksum="2B9D9395F086E50C" modified="2018-07-18" version="1">MTTRSLPSDASSAFDYIIVGGGTAGCVIASRLSSYLPERRVLMIEAGPSDFNLNHVLNLREWLSLLGGDLDYDYGTTEQPMGNSHIRHSRAKVLGGCSSHNTLISFRPFRHDMDRWVAQGCKGWTFENVTRHIDNLRNTFQPVHARHRNQLCKDWVQACASALDIPVIDDFNAEIREKGQLTQGTGFFNVSYNPDDCRRSSASVAYIHPILRGEERRPNLTILTEAHVSKVLVENDVASGIIVHLASGEKVVLKPRKEIILCAGAVDTPRLMLHSGLGPRSQLEGLGIPVVKDIPGVGENLLDHPETIIIWELNKPVPPNQTTMDSDAGLFLRREPTNAAGDDGDAADIMMHCYQIPFTLNTERLGYRRIQDGYAFCMTPNIPRPRSRGRLYLTSADPAVKPALDFRYFTDPEGYDAATFVAGIKAARKVAQQSPFKEWLKEEVAPGPKVQTDEEISEYARRAAHTVYHPAGTTKMGDVTKDEAAVVDHELKVRGVGGLRIADAGVFPEMPTINPMLTVLAIGERAAELIAMEEGWKPKTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS44</accession>
    <name>A0A2T4BS44_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1395133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS44"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="49249" checksum="F57BD984AD42991C" modified="2018-07-18" version="1">MLDDKATARSTIVDIPVDVPKPYLPEGLPDGITLLSPKKIDHRTDEEISAWLQKRHPVTAEKNIWGFWHNGFANMKPWTQRNVINWVRRLGPEWTVHIVDRLDGSETNVLNYVEESYFPKTFLEGTMDGHKAHMGDLVRLPLLWKYGGVWMDVGLILLRHVDDICWKRIEDPESPYELSAVALMHLPGTYTPLNGFLGTKSGNPFIKRWHDVYLALWEDGVTNAKGFHKHPLLRHLPLFKPDMSTVNLEDDVNFDPVLFSDYVAHYMCGERIRKLVDPNDGFNGVEWYDKHMLIFDAADEMLYAQIITKWDVETQFRLLSLKRFGEGAVINNEWHEAEEFVNTLLAKTAMLKFPHGPGGEGLKVKMLADLWDADEHRNKDHEEGTFAAYLRYGSVHFDQTREVKKLAWQNPEEETFTVGYLEPVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSD7</accession>
    <name>A0A2T4BSD7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1405605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSD7"/>
    <dbReference type="STRING" id="983965.A0A2T4BSD7"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="474" mass="53431" checksum="750559C9420CBD58" modified="2018-07-18" version="1">MEYDPKTPKSATSEPHSFASDSVRMRWPVIITGAVDDVYKAISSTDDAEKQAEGKKIIEQLGNLKYEMLHDRKLTPIPDDGFSEEIAAYNKELEQLGNPSWFNVPWLFAECYMYRRINSFFTTTKHWKSYDIFARQKTDTFRTSRNAVVELAARYRDIISKLRSDKNAAHDVEAEKILFTEMCEVCLWGNATDLSLLTNMTYDDIQKLQGSEARKAAEKNILVNDLPRAYDLLKKAQAEGKKERRVDFVLDNSGFELYVDLVLAGFLLNTGLATHVVLRPKSIPWFVSDVLPADFAALLSALASPKRFFETPTEEEKVADRTPPPLADKEVENLLFVFQDWANLHAEGQLTIRPNRYWTAAGSFWRLPKEAPELYEDLKQAELVIFKGDLNYRKLTADAWWDPTTPFQEALGPMGANSGVNALALRTCKADVVVGLPPGKDEELRALEGGGGDTGARKWAWGGKWAVVCLSEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSW7</accession>
    <name>A0A2T4BSW7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1405404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSW7"/>
    <dbReference type="OrthoDB" id="4867305at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="315" mass="35031" checksum="3A4F51035E439F1D" modified="2018-07-18" version="1">MPNLPPAFQVFPALTRYAALRPRRLAEIPIGGPSAPQISAKALQQSAIHLYHDLGVLVWVGCSVEQVRRIGDVLKQVVAWGGQGGLVARLDAWEGDVVRRREGVVGEGDLYRALDEKRTGNLKPSAILRLATTRFEETLRERIPELKTAKNIDLRETQIIVPGSPPPRGIINKTVDGPRHLPIESFTTIGVDRITGLTISETRFFTVGSSNYVGGARVDYLMLKHTQNDDSKKAKGKSLPDRISVMPYWGNGKLKQRRRASDEAQGAIFEDVVSRVMQPLWDIERSTWADRAAELEAKREKKNWGEKTRPSTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTP6</accession>
    <name>A0A2T4BTP6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_148333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTP6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="15927" checksum="97BF5788F36B2231" modified="2018-07-18" version="1">MIFLNAFVTSIYAAGCAPAKTMGNKNKENENPESRFQPFLPHELSLMQTPFHPAMYMYQSPEALLSINSSRSLVWHVIHGAANPILLRFYRLALQFFFFCFFFLRQFPVSFILSMPGIRCSMIHPLWAHVHASGKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUP2</accession>
    <name>A0A2T4BUP2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1425032</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUP2"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015568935" description="ribonuclease T2" evidence="12">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="257" mass="28238" checksum="D982A2D2575B8F78" modified="2018-07-18" version="1">MHLRNPISVLAALASVAAAASKTCPSNTPLSCHNTTVVEDSCCFIPSGQLLQTQFWDTDPSTGPSDSWTIHGLWPDNCDGSFPQTCDASRAYTNITDILTAMGADDTLQYMQTYWKDYQGHDESFWEHEWGKHGTCITTLDPGCYDDYVPTEEAADFFSRTVSLFKTLPTYRWLADAGITPDGSKSYALDDIQSALSQQHGAEVTLGCDGKNLNEVWYHFNVKGSLQDGQFVAAEPDGAKSSCPDSVYYDPKNGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUP8</accession>
    <name>A0A2T4BUP8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1404764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUP8"/>
    <dbReference type="STRING" id="983965.A0A2T4BUP8"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="3">
        <location>
            <begin position="252"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="533" mass="59634" checksum="2ABBC99AB6D27F29" modified="2018-07-18" version="1">MSRSWKDRLLSPTAPSEEALKASTVDEIMAALAWLREVKREKPVSGQEVDQHPRIVQLVQHLLRVENRPITPFIYECMMDAMADPRGSVDGLRRLLDDMVEQGMKPTAELCNGALRALMNHPDYAMRMEILSIMQEYWFTIDTPVKQTVVVGMLRDEQYELAYARLTEMIEQGAKLDTWVYDIFILVFGRHGFLDEMLQLLYRRKNLGGSNDPIVISLAYYALDVCSQAYHHAGTLFGWLSVVQNHLVQPSDGIIENVLGTAARNADARLASEALAMASERIRAQTHHYEAVVEAFVGSGDLAAAIRTLCIMDDNGLRIGRSQTRRMHAILRSRPELLDSAEAAVRETAAARPVPRAAAAAIIEALAQIHDSARALPLYRDLPTLCEAELPNARMIQTLLIHSADEATAKFFAKEYAEQISQDEDPKQTNQSLSALITKCAEAGEMDLAFRFTKQALAGGITRSSRLSSSPRWIHVLVEQAMAREDGRVWPVVDELLSTGNEETTRVVRRMLQQKRISKLASQWKVGASRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUT8</accession>
    <name>A0A2T4BUT8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1340382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUT8"/>
    <dbReference type="STRING" id="983965.A0A2T4BUT8"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="158"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="551" mass="60731" checksum="B5B51936FC647AD3" modified="2018-07-18" version="1">MASDAGSPKRELTPTASVSSIPQKRAFDEGHSPAVPSPLNPDVRPPSEAHHADDASQLGRSKPVRAKKDTLKKREAKGGDSNPATPDPKAGREPEPSENRPLRYKLAPPKLSDFDPPRGPVMTLHHRVDGPDGQAIEFMETSDHVFNKRNFRYTPCIADPLFPSILYYRQTEPEPFGPRMSFEDAATHVFFDRSGRQVTTDKGFRMARANVAVREGRWYWECKITQGIQPPKDGDTKPVGGKHVRMGWARREASLDAPVGFDAYSYGIRDVAGEKVFMSRPKEFFPPGEGIREGDVIGLEIQLPSEHLHRKIMAGHYNPAVDAADEPAPSTAEAANIVRDRVPIRFKAHTYFEKIEYHTTKELEDLMNPSPAAAANSSADAPSPTHPTPALRTLPNSHIKIYKNGVLMGTAFENLLGFLPPASKPMPQVGAREGLDDGMLGYYPAVSVFRGGAVEVNFGPDFWYPPADYDSTNGEVDMIQPDGVSANALHAVVERYQEQIAEDIVYDIIDEVDFWMQDGGGATNQAGVDEKSKEVVMAPGREEIKELVQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVF5</accession>
    <name>A0A2T4BVF5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1340589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVF5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVF5"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="261"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="508"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="783"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="909" mass="100466" checksum="2BEE2244F4D8BCDD" modified="2018-07-18" version="1">MGKSATPASSPRASHPAGQNYPPKISPLRPEARPPSPNYFGLVVDSHDPRDSSGLGNNWSPTSSSIKSFAAALPKHVESNPEFEAFKRQVDINRGKSFALPTSHYVQPTSNPAIVRPRPPRWHTHASDTGSESSFPRALNLPRERPSSRMDVDQDSLHDSAYVSSDSKRNSEASLFPLQLPGIAIPRFESPMPMDPMQSRTSLTRSEDRDPRLSVMEHRPEPPSPKMSDMTRAVTMPTKLEPGQPSLITAAYLKDLLVNEDEDSLLLLDIRSSSNYASSRIKGALNLCIPTTLLKRATYNTEKLQQTFSSSSASDKFSTWRDVERIIVYDSRSSDQRDTVAAQNMIKKFTNEGFTGETAILRGGFQGFQTSYPELVDSSSTVSTDSDGGALPGAMRGLAPVIGGVMLPTSKNPFFSNIRQNMDLADGVGQLDVAWPHGLEPGVLPMWLRDAAAQPDHGKRVSDRFLRIELEEKTRMQNAYAAFNEGNVAQNPAMNGRVQLSGVEKGGKNRYKDILPFEHARVKLQNRPEGACDYVNASHITASGSNKRYIASQGPLPDTFEDFWSVIWEQDVRVIVMLTAESEGGQLKCHTYWKDREYGPIKLKQLSEKKASLDLDKHRTSNAQSNNAATSNEASRKRANTTTTLETTAANPPPPQSQSEAFVTIRKFALSHSAHPFSPIREITHLHFSSWPDFGTPAQPSHLLALVELANVMQRAALPVETASVVGSSKIAHDMTPLSWYDEPEADSASRPMLVHCSAGCGRTGAFCTVDSVIDMLKRQRLAKMPGGQQQPARDAGGDTPMADSDDAISPMTNREMGFKFNLERQPRLETPGTHGQQSIDVSWLRDESVDLIQKTVEDFRGQRISMVQSLRQYVLCYETVLEWINRLHDRGSGSTPGRRHRSESYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVM0</accession>
    <name>A0A2T4BVM0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1404370</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVM0"/>
    <dbReference type="STRING" id="983965.A0A2T4BVM0"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF4">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="14">
        <location>
            <begin position="24"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB73358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="393" mass="42301" checksum="4BD13134E7076294" modified="2018-07-18" version="1">MSEAQTVKSMTIETPRPNPSLQATADHNIKLVEAPVLRPERGEVLLHIKATGICGSDVHFWKSGRIGSLVFEGDCILGHEAAGVVIKCGEGVTNLKPGDRVAIEPGVPCGQCFLCLDGRYNLCEDVKFSGVYPHAGTIQRYKTHPAKWLHKLPNNISFAEGALLEPLSVVLHGIRTAGLALGCGTVICGAGPIGLIALAAARASGAHPIVITDIEPKRLQFAREFVPSCRTYQVDPSLSAEENGHRIRQLFRTSEEQPLKSAEGDVLEEYFAPRTVLECTGVESSVCTAAFAVRRGGTICVIGVGKSIMNNLPFMHLSLAEIELRFINRYRDTWPAGIACLSGGILDLKPLVTHVFPLEDAVEALHLAADARNGSIKIQIVDEAHEDVLVGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVZ4</accession>
    <name>A0A2T4BVZ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1062359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVZ4"/>
    <dbReference type="STRING" id="983965.A0A2T4BVZ4"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="94865" checksum="1C387D77438D345D" modified="2018-07-18" version="1">MASPGGNINILPFGTEINPLYAGIAATLLGGIVISSLVASRGTGKDGETPGVLRSFVLFFYSCFIKPHQGDSKASQQDALESFYKKQAGAYDATRKLLLRGREDMLALVAAQLEAKAKMASDDSKTKRIWVDVGGGTGWNIEAMARFVDVPSFFTSVYLVDFSPSLCEVARRRFERLGWKNVRVVCQDARKFRLEDYETGMKQQVAPRSPSLSYLTQQRQDYGGADLVTFSYSLSMIPDYYSVVDSVNSLLAPHGILGVVDFYVQNQVDFSFRNYTGGLVDRHVNMLSRNFWRAWFDIDRVGLEPGRRDYLEYKFGTVLNSNFRNRTLGYIPYYIWVGCHKKPFSPSSLPHEIVERIDALATESPYLYPANQGDALTRAIERSAPEIRSKAFITAVENLSANLPLPSFFYQNHHWRIYYDDRLQKHTQFNDEYIYAFTWEDARVDERLLKLGPDDKVLAITSAGDNIISYLAQSPARVHAVDLNPTQNHLLELKAAAYTALPYEDFWKIFGDGKHPDFRNILITKLSPHLSGRAFQYWLKNTRVFQNNKGYGLYDTGGSRHAIRTFRWIARVFGLQSAVKKLLSVRTLNEQREIWRNKIRPALMSKLICNLVVAQESFLWAALGVPKNQLAMIEKDHAESDIVKQGKAKNTRSHAIWHYMVNTLDPVAEETHIGADNPYYYVCLDGKFSRRCHPEYLRPEVHAKLSRPGALDGLRIHTDELEEVIARISPGTLTVAVIMDSMDWFDTGSHAAAAQISKLNRALQMGGCVLLRSSALSPWYIKVFEAHGFAARGHGSRVGGACIDRVNMYASCWICTKTENLPPPTPEFDRIGGTDITSLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWQ5</accession>
    <name>A0A2T4BWQ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zf-C3HC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_57804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWQ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BWQ5"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="275"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="487" mass="53994" checksum="9A23106DBCE9950B" modified="2018-07-18" version="1">MNSTKRKFNALLQGLSSPRPSTDDESSPAAMFGGNRVPSGSRVVDHEAMLQKRRRLGFPDETAPRMEGPVSSGLTSLASSIRRTVSDATTPKVRRDGPARYSPGDRDELLKRLATFQEITDWTPKPDKISEVEWAKRGWICQGKERVRCLLCHKELVVKLKKEAAEGEDGLTAAEVEAALVDKYAELIVSAHQSDCLWKRRGCDDSLLRISFVSAKGAIEALKGRYEELCSRAAFLPYEFNLHLPEGMNLDDVISQLPPEFFTGRNPTPEPVRPALALALVGWQGLNNTRIGAVPNTASCHTCQRRLGLWMFKSKEVDANGNVVVPAPMDYLDPEREHRFFCPWKNPAAQSRGHSISKDDAPDMPAWKILLQSIKNECDLRRVYEGKLKPSSKPAAAAAAAAAPSTPVKTPARQAPHHTPNASVDSLAINEEDDEAARDAKDKERWARLRKVKSLFDTKKLRKSVSNRPETPHSIKSHKSSRSIKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXQ2</accession>
    <name>A0A2T4BXQ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1338291</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXQ2"/>
    <dbReference type="STRING" id="983965.A0A2T4BXQ2"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="201"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB74109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="697" mass="79756" checksum="8E3D6FD5780BE49F" modified="2018-07-18" version="1">MAASQDQQKVPQDGTGVIQLDPWLAPFSDALKRRYSKAQDWIKRINDTEGGFEKFSKGTDIFGFNVDENNNVTYREWAPNAEQAYLVGDFNGWNYESHPMKKNEYGVFEIVVPAKGKEKAIPHNSKVKISLVLPGGSRVDRLPAWIKYVTQDLSVSPAYDARFWNPEPSEKYSFKHPRPRKPESIRIYEAHVGISSPEQRVATYDEFTDNVLPRIKDLGYNAIQLMAIMEHAYYASFGYQVNSFFAASSRYGTPEGLKRLVDTAHEMGIVVLLDVVHSHASKNVLDGLNQFDGTDHQYFHSGGKGNHELWDSRLFNYGHHEVMRFLLSNLRFWMDEYHFDGFRFDGVTSMLYKHHGIGTGFSGGYHEYFGFDVDEEAVAYLMVANEMLHTLYPECITVAEDVSGMPALCLPLSLGGIGFDYRLAMAIPDMWIKILKEKKDEDWDLANICFTLTNRRHGEKTIAYCESHDQALVGDKTLMMHLCDAEMYTNMSTLSPLTPVIDRGMALHKMIRLLTHALGGEGYLNFEGNEFGHPEWLDFPRAGNNNSFWYARRQFNLTEDPLLRYKFLNHFDKLMNTCEAKYGWLHAPQAYISLKHEGDKVVVFERAGLVFVFNFNTHRSFSDYRIGIEVPGTYKIVLNSDSDKVGGHNRVDEETRFFTTPMEWNGRKNWTHIYIPCRTALVCFPGQAANSCAKDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXZ8</accession>
    <name>A0A2T4BXZ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1403560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXZ8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="14436" checksum="B94318C531744962" modified="2018-07-18" version="1">MSFKEKQRPAYGVLRDPAAGPRSPMSKQMCVCDRNRASGEMQRRLAWRFDGVNGMGSGRLNCTRLATIWLTRQRRDDPTRHCTSMCCSIVRGMVSINTVASLMGFLLFMILQTRVANELKAVSSAFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY00</accession>
    <name>A0A2T4BY00_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1440373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY00"/>
    <dbReference type="STRING" id="983965.A0A2T4BY00"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="105"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="219"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="306" mass="32250" checksum="11FE3EFF4660765C" modified="2018-07-18" version="1">MAPPPSPSFQSALLAGALAGTTVDLSLFPLDTLKTRLQSSAGFFPSGGFSGIYRGIGSALVGSAPGAAFFFCTYETTKSFLGSRLRSSSHGDADNAAAVNAWVPADILTHMLASSLGEIAACSVRVPTEVVKQRAQAGHHGGSSARALAHILSSGSGSGGRRRSLPAVWRELYRGWGITVFREVPFTVIQFPLWEAMKAWGRRRRGDSGGSKGDVSAGESALYGSLAGAVAAAATTPLDVLKTRVMLSKERVSVADVFRRMAREEGVRPFFAGIAPRVTWISIGGAIFLGSYQWVINTMNSIHVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY25</accession>
    <name>A0A2T4BY25_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_109820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY25"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="61" mass="7122" checksum="AA0ACD0577EC5051" modified="2018-07-18" version="1">MGILLETVKRMSLGWRRAWGGGSKRIGIWIIWDRLVGEYLLFASWLFILGGVVWMIWVDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY27</accession>
    <name>A0A2T4BY27_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_110750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY27"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="248" mass="26263" checksum="97616661B9A9020B" modified="2018-07-18" version="1">MSGCWKVRRVQRAVTVLLGTSEMGRQDHDQKLRGQGEAYRQVRTCVSLLNGAARRGTGGPKRPAALGENLWKPPIEQGQGEMTEALGDVSRVSGRLPGDANAVWKTVAGSGLLDPSLEGMRGMEQLAGSLRGSMSGDRLGGEEKGIALPSPWFLICSAGPPFWRWDSFYGQEPGGGIDARAAMLGSSSVGGLSSGLAGDGLRVRGGGGGWQDRICVGGFSRQGQNRAGRRRWAIKGNRSGQRGEREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYF2</accession>
    <name>A0A2T4BYF2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ribosome biogenesis GTPase Lsg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1471648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYF2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYF2"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001151">
        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="175"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="649" mass="72128" checksum="781E4663BAFC8933" modified="2018-07-18" version="1">MVLAKSKKNEGLGNTLMNDRFGKGKGSDHKKTSAVMRTNHTTGEQYLVNEKKDAAWVKMRSVTEQGALDEFLATAELAGTDFTAEKMNNVKIIHTDQRNPYLLSATEERAVLGKHRQHKNRLTVPRRPQWDASTTPQELDRRERDALVAWRRGLAELQENNDLLMTPFERNIEVWRQLWRVIERSDLIVQIVDARNPLLFRSEDLESYVKAVDPKKENLLLINKADMMTTKQRKAWAKHLREAGIAYKFFSAQLAKEMIEARENAEDESDDEPAFSSKQAEKAPQQEAEDEHGDEAEQGESSKGKEPVDEDTQILTVEELEEIFLKYAPNDRASDHKLQVGLVGYPNVGKSSTINALIGAKKVSVSSTPGKTKHFQTIHLSDRVILCDCPGLVFPNFATTKADLVTQGVLPIDQMREHSGPVGLVAKRIPQPFLEAIYGIKINTRPVEEGGTGVPTAEELLRAYATARGFQTQGLGQPDEARASRYILKDYVNGKLLFVHPPPGIDDEKAFNAELYDEAHLPERRRAALAAATEALSLGADDDESLASEFISLPQGPKSQKLDKSFFTPKNVRGHVSQPFNYKYSEQGSSSGSTAGGTKMLSGRKARAAIALENGLDPKDVQLGSGKKHYKKGGMPVSTSFTLGRRDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZG1</accession>
    <name>A0A2T4BZG1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1403202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZG1"/>
    <dbReference type="STRING" id="983965.A0A2T4BZG1"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015538688" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="30775" checksum="72294DB5095FF577" modified="2018-07-18" version="1">MKSVAVASALLVAAAAAQPHHGHHARFHAHGHKHAARDVVVTETEWHTDTVYVTEVVDSTYTYWVQDGKTSSVAPAETTASATLSVSAGEFFEPTSTAEQATSTSQAPPPPETTTAAASSVFTPPPPPPQTTSEAPVVVSVPPPVVHTTSAAPPPPPPVVETPTPSPSPSPSPSPLPSVKAPSPPANVDTGSSSSGGSVGTYSGDITYYTIGLGSCGDDDTGKDQSENVVAIAVGLMGAISNGNPMCGKTITIHGGGKTTTATVKDKCMGCAEHDIDVSEKVFLELFGSLDGGREPVSWSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZT1</accession>
    <name>A0A2T4BZT1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_104728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZT1"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="41252" checksum="30879D3F315DF3A0" modified="2018-07-18" version="1">MNWMGGNLSRHRRGKGWKEELARQKEYFAKARSRLREQDKSRPPGTLSAADFVPNYTSPAKIPTAGLHGAKVNPSSVLCDKPVPAAPEVAASLRDWPKILPRHVTKPPTAFPLGENDRPQPLSDKAVGDTSTGASAPAAGFRRLMKRIDSAGTELPRRTTLQPRGEGHQSTNFRHTAEQQKQPVVSLGHRKPSEGGKQRDNRKRKLRQTTPSPRSIRIRVGSQDYRWNKSRNSIESPAYGEFWQAQGTAPKRPRNRIQSIDAIHSSRLVDEGLTGSSSSSSHPTLSSPCKSRASRLRQLHSSTSHVVGQTPAELENRVPVYDCESAPKSPSSAPSASEIDSTDSTAVQASDDGHMPEFEMDEERIWRQWLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZV9</accession>
    <name>A0A2T4BZV9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="9">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1432179</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="9"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZV9"/>
    <dbReference type="STRING" id="983965.A0A2T4BZV9"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="56"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="141"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="10">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB74828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="385" mass="42913" checksum="7E5D957C9BE853CF" modified="2018-07-18" version="1">MSPAPRLLASLSRRAALRPLQPLRPSSFGAVQTLSVAAMAARNMATAAGKIKVKNPVVELDGDEMTRIIWKSIKERFIFPYLDIDLKYYDLGLEYRDQTNDQVTLDAAEAIKKYSVGVKCATITPDEARVKEFNLKQMWLSPNGTIRNALGGTVFREPIVIPRIPRLVPGWKQPIIIGRHAFGDQYRAKDRVLPGPGKLSMVFTPEGGKPEEIEVFQFKQGGGVAQTQYNTDESITGFAHASFKLALDKKLPLYMSTKNTILKKYDGRFKDIFQELYDTQYKAEFEAKGIWYEHRLIDDMVAQMIKSTGGYIMALKNYDGDVQSDIVAQGFGSLGEKACVDTVDADGVMTKDLALACGKTGRGDYVTTNEYLDAVEKRLKATLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZX0</accession>
    <name>A0A2T4BZX0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1336728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BZX0"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="77"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="507" mass="55574" checksum="C7C7519837C08EFD" modified="2018-07-18" version="1">MSEKFKTPEDLEATASHSSGFSRLASMFGGPNVWVGPRIAPLPAYLKNDLSESEESSEAILNRQLASEDGTSIQYRTCSWQKTAALLFSEYICLAIMSFPWSYSVLGLVPGLILTAVVAGIVLYTSLVLWEFCLRHPEVRDVCDIGQMLFWGKEWAWWGTAIMFVLNNTFIQALHVLVGAEYLNTMTASDNIGGCRTVEFGVVVTVICLIASLPRTFSMMSKLGTASAIFTFISVVLATIFAGIQDKPAGFTEKLGSPLVTAIPVKGTTFVNGMSAFLNISYTFIGQITLPSFIAEMRDPREFPKSLWACTIAEIIVFSIVGGVIYAYTGNQYVTAPAFGSLDDMYKKVSFSFMIPTLIFLGCLYASVTARFVFFRAFRNSVHLHSHTVVGWGSWAGILLVTWVFAFIISQVIPFFSSLLSVMSSLFDSWFGFIFWGVAYLRMRNADKEVGRKRGLASAFATAVNIAIIIIGIFFLTVGTYASVQGIIDAFDAGTVHGVFSCKSNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZY4</accession>
    <name>A0A2T4BZY4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_104003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZY4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="190" mass="20625" checksum="9E1A46D5E9FFCED8" modified="2018-07-18" version="1">MFEDESQIFARCTKRADIRVNVDEGFQRVSGLQMLDKHSNMTIILANLSVLKNILQECPVSSFLSTPMLAKDVNAKCGINPCPTKLEAESQLKAKSSRSKASFDSVVWFASFEAISLVEFGLASSLAALAKTGPCMQESKPMYAALMNLCPRVLFPFNSACNLVRLSVDWSDGSSCLKSHPANAGIVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0B5</accession>
    <name>A0A2T4C0B5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1423123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0B5"/>
    <dbReference type="STRING" id="983965.A0A2T4C0B5"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32554" checksum="2344B263E6F10B42" modified="2018-07-18" version="1">MGDGLAPFRAVDTYHMAFVVHYSRKIAKAKKQKLKDKEAAVIEGEGVGGDSVELTHCASGDPLRDNAAQVGAGLSSNPQSAGVSVERLASTSSNLPSGMPQPQPMPVPVRAPAPELEQAMVDHNADVEAAKLDIEYDQDSPLTFKQWKRMRHHQKKLAKSHSFYKPDETFTHHAFPLSYLIAIVILLDCHSCLQISLGATTWGIDYHHRPFAITTVILCVSITCNITAGLVIMVGDRKTRKKDVWKLLTRQELTGDAIKHLETKRAKEQSRSHDSSQNSIQDEVQTDAVIIKEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0D7</accession>
    <name>A0A2T4C0D7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAPS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1392517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0D7"/>
    <dbReference type="STRING" id="983965.A0A2T4C0D7"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="906"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="932"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1033" mass="112311" checksum="A033B8E54F6A3CF7" modified="2018-07-18" version="1">MFWRFGGYANISTIDTILDKPDFTLEELLEEADLIQELKQHNSKLIEFLREDKVLEKLLQYTIAPKLEAVEGAEEPADDDIKTKGRLLPFSRPRASSQATDSGENDDELDKKRNRYAHVACEVLSSDTWSIYEALVENRQLIREFWNFLSRPAPLDPLQASYFTKVNESLFEKKTDEMMELLFSLPNVIPDMLRHVECPMVMDLLLKIIALDRTEGGQGVVEWLYSKDIIPTLLSFLGPEHSWVVQTAASDFIKAIITISANASQNEQQCIGPNELTRQLVSKPCVEQLIGYMLGGGNPLTVGVGIVIEVIRKNNSDYDPDVGAEANTLPSSRDPIYLGTLLRLFAQNVPNFMNLIMNEPSKKQSVASTFNEKLEPLGFDRFKTCELMAELLHCSNMGLLNEPGSEQLIAHRDFERQRLRAEGKLSPRDEDGSADDLTMRMPHPAHQEEVRRLEVTNADDDGFEEVEPTSEMNEDTSHEFVKAEDDIAANPSSSSFLEKDEEEFVDEPLSSPRLAVATANINEQRFDEPDLVVAPLSPAKAKAADLAQAETENPTAGEASKTAANEHESESASTVLSGPIVIATPESAEAANSETSGTEAPSQTEAQKPGLQPSALPRDEDTKKSAAAPSAPQEVAASAADRLVPDEADKSRGLSPHPEDTPAPLFSAPLAPDSGVQEPPRDGSFTPPQGPEPALAASEEKPGETVSDAGETVVGDFLKMQFVEHRVVPAILSFFFAYPWNNFLHNVVYDIVQQVFNGPMDRGYNPTLAVSLFEAADITSAIIKGQQASDESQAKTKTRMGYMGHLTLIAEEVVKFTERHPPELLSETVLDKVMSQDWINYVEGALAETRERDNAILGGVRPEVAMGHRVSLGGSGLGGIGLSGLGNSASASNALAEAGLNGGMEMNEGDGNGGGPFAISAGTLMSGFGSSSDEDDDEGEGDEEDVNSEVSFDSSDEHGNESPEATMGMTRAPEDVIMMSPEPIRAGSSDAMAGLEADADLDAPGQDIMVIEEGGWIQRRDPSQGPNRRLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0M3</accession>
    <name>A0A2T4C0M3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_20286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0M3"/>
    <dbReference type="OrthoDB" id="4900209at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="26661" checksum="71BA4E95C91AC509" modified="2018-07-18" version="1">MARSLKDAHMPPVHDWEPEHGDDSGDDADDEESPFGDFLESHTEDDDEIIADMKEMRLALEYLRGVLSASKAQRASTSKAAAEKADDEKGVHAEDSVVDDDDDDDDFVFLESDEDDDKTQDISRSCLELLIELDYIMLPTVGVDLFRAEMEFMLLGDKDCAVNGGGAASPSARVRSKWQLLYEKFYDEDKKSFKEVDLDSWRREVVQTCGDLFKDVCALWNSESVGEVADGFGVADFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1P1</accession>
    <name>A0A2T4C1P1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1402030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1P1"/>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="225" mass="24670" checksum="E307B1376E3343F8" modified="2018-07-18" version="1">MSAPAPNPVVAPDHIHALLKHLHQESLTQEAALPSGYLGSPNGFDELMRDKFIALDQDKCQFVYQLARATGARNIVEIGTSFGVSTIYLALAVGSNLEHLGGEGVVIATEKEHTKAEKARHHWKQAGDDLVTRHINLREGDLLETLENNIPQVDLVLLDIWAPVALPALKLLEPKLRSGAVVIIDNSISSASRYKELLDHLRSLTSGYTNLTLPYSKGLEMCVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C276</accession>
    <name>A0A2T4C276_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1470633</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C276"/>
    <dbReference type="STRING" id="983965.A0A2T4C276"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB75673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="485" mass="54084" checksum="ADC0E2977A3E097F" modified="2018-07-18" version="1">MAKPKQAAAEQPHGYEFGGPLGAFGISFGLPVLVYLFTFSCNDVSGCPAPSFLSPKTLSLDKLKLEVGWPKDGIWGLASWEASAALAGYYLLNLILYAILPAQKVEGTVLRSGGRLKYRFNTLYSNMATLAALAAGTIAQGAEFPVWTFISENYVQLLTASILLSYAIATFVYVRSFSVKAGNKENRELAAGGCTGNMLYDWFIGRELNPRITIPLIGEVDLKEWCELRPGMMGWIILNCAWCAQQYRNYGYVTDSAICITVVQALYIIDSWVNEAAILTTMDITTDGFGMMLAFGDLVWVPFVYSLQTRYLSVYPRSLGPLGLLAMVSLIATGFYIFRSANSQKNTFRTNPNDPSVAHLKYIETKTGSKLLTTGWWGIARHINYFGDWIQAWPYCLPTGLAGYQILAAGTPTAEEAFVMADGRQVIQGDAKGWGMLITYFYIVYFGILLIHRDGRDDLKCYRKYGEDWNKYKKIVRWRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2C5</accession>
    <name>A0A2T4C2C5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase Rpb6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1439408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2C5"/>
    <dbReference type="STRING" id="983965.A0A2T4C2C5"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16966" checksum="E8998436F62C54BE" modified="2018-07-18" version="1">MSDFGDDDVSVGGDEPVLEEDEITEFYEPEVPEDEDAEHLNGDEQDNVVISGDPSAAANASKDKSVKNKKIPDDQRTTTPYMTKYERARILGTRALQISMNAPVLVDLEGETDPLQIAIKELREKKIPLIVRRYMPDGYYEDWTCEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3G4</accession>
    <name>A0A2T4C3G4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3G4"/>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30440" checksum="57D1E8E0BB0DFF62" modified="2018-07-18" version="1">MFETVNAPSTMVGPDFASILHPVSEPSASPQSVPRTLHTSNPKNVLTTEHRVLKKQREKVRRDSKVHSRVQRTTDTNDHPFMQASLAAITSAMALPVYATAAPTTISLLSEPTPTLSEPQYLPPYSPHMSEPAFNTPYQQQMPSNYSMSMDYQPNYATAGAYSIPHAPIPGQDNGMVYRIPAMHSNGPASSATSTGTGSPDSTGHVRVVQNRPKPRCWEHGCNGRQFSTFSNLLRHQREKSGQAAKATCPNCGAEFTRTTARNGHLMHDKCKQRRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3R5</accession>
    <name>A0A2T4C3R5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1247637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3R5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="16733" checksum="12B18311FF849406" modified="2018-07-18" version="1">MRMYVRSTAGIHMYAGAFHRNEIVPHFFTRSPADDTTSQLAELKVLGPADASTGDRSVEAGPPLPSPFLLASLASDRAVGLLLRKVRCPICRDTAIRKCGRGKPSTSLEQVSPGPGCRFSKPSFCFFRPLALGHRYWLSEMKPPANQTSPRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3U3</accession>
    <name>A0A2T4C3U3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1401692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3U3"/>
    <dbReference type="STRING" id="983965.A0A2T4C3U3"/>
    <dbReference type="OrthoDB" id="4898535at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="97884" checksum="9D340A19EE0AB66E" modified="2018-07-18" version="1">MERAAREGALCFVQVLKTRGAKDNPTPLMSAIEHDRIQVADFLISHGARDGEALRTALLQVGLLAIATRKRDSTTLMLLKLERGTGKLATRSDLREEVDELFEATVVDFFDDKGPRKDDDFFSVDDDVDVKFRWFHLPANNAVIGKIYHSDPSSAYKVLDPKRWVKRQHEGERGSAHARFMIPACHDFSEAFKDKKSQHLGNGGNDKHVFLFMPYLHWDEEEAMQKRSLFIAENSPGAANSTKWTKLNSKKEELLLRHYLLPENHCDPSARHILHIRRTLDQYLYHNLKDTRVRDADQTVHRYQNRLNGEKASDRKDPLTAIMVDQLWLWTLVGSSGKAEAIVTCFPSRDWNDVGMRATQQTRILDPRRTTDVLQITKAYIQQRPSAVQSPYDLAGVIASRCSRALLDHSSDMLNFAEVYENSISYIMNEEAVLFNTFNALMQTRTKPDENGLAPEQSLKRAGSFRGLSNKIMGDLGSLEELLKQEMHQRREANSPLRIAGQTTDEKDQVDQRRQKIFQSAEGLCKIYREYTLDREIPDDSDIKKLRTLTGREKVEHFINLLEKFGRFCVLDIAREVTLLRQIKDIQDELEMMEKVFAEQKEALESMDRIIRTMNQHGLDPSDDAQTIASTHRPAHRRASHGRIMERDHNAHHRSLLIDIMDDDTDSDGEGMLGHDYSLSAGSGDGVPGTERRGSNNLLSKLSRSMIWGDLRERQNLPLRTITRHSKQIKRMNERAKNTNSALSTLVDLKQKQNNMIDARTARLQAEQSHLMTLEAEKQGRTLMVFTIVTIVFLPLSFIAAFFAIPTKEFDNNSLTLGYVSKITFPLSAAISLVFIAIGFLASKWNTEKVKNKWNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C420</accession>
    <name>A0A2T4C420_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1249583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C420"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8492" checksum="33D4A7DEA36D11FB" modified="2018-07-18" version="1">MQLSKKTESSSEETMVRLSGRSLKETELPYHGRVSQLLRYKPLASNCSSRGNARAVVVVSAISLMYCTSRKQDNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C486</accession>
    <name>A0A2T4C486_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1250593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C486"/>
    <dbReference type="STRING" id="983965.A0A2T4C486"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="155"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="564" mass="62472" checksum="FC75B1EBA0DBA4AE" modified="2018-07-18" version="1">MAKQKLLFEQPGIRITLWYFTSHPRSPADVRDVSQHAYCSQVKEPVLSHPQLGRRAAQSKQCVSATKPLTQLNLFPSLSQLTALGEPPQHQNTTYIFHPSTQPPSTPHLPPPNLNHTKPIIMALSSRASKLTTPDPSFSILQNPYHPSLNPSGTINLAVAENALMHTSLQSHLHAHLHTIPTSAFTYGDFFRRSRSAIAAFLTKHLHAITPITPDHVAVVSGCTAAVEHLSWTLADQGDLILLGRPYYGAFSWDATIRTGAKLAYVDFKDDDPLGSDCIKSYEDKILEAHANGEKVTALLLCHPHNPLGRCYPLPVLVDLLKLCNKYKLHLISDEIYALSVFENAVDAEPAAAPFHSVLSIDLEGLIDPAYVHVIWGMSKDFGANGLRLGAVISQHNVGLMTALFPLVLLTSVSSLSEHALANILEDESWVESYIKENQRKLSAYYEYVTAWAKTNDIVYAPGVNAGFFLWADLGRTYLKHHKNDKTEDLDQAVMDALLRHKVFLASGARFGSERPGWFRIVFSHDKEYLDEGLRRIVAALTTPEPLEQSEIDLARGSITAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5V1</accession>
    <name>A0A2T4C5V1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1462707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5V1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5V1"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18112" checksum="B68C298E1E40E5E6" modified="2018-07-18" version="1">MSTPFESQILEANAKYASTYKHSGLECPPLRKAVIVTCMDRRLDSKSAYGFDLGEVTTIRNAGASGRDAARSVLLATHVLGAEEVLVIKHTRCGLLGVPGEVVYGIMKKNLGLAESEEVEDFEVLTFFDLERLSILTIILLRGRSAALRFAVNEVAMVSLKGRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5V6</accession>
    <name>A0A2T4C5V6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1438652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5V6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5V6"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015481160" evidence="1">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="45"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="323" mass="35922" checksum="5D092C8247848338" modified="2018-07-18" version="1">MALLHIILTLAPCMVGATCYRGYQSAYSFDAGDSPRPDWMAAIPDDVHLTSLSIPGTHDTMTYGIASQTLQCQNWNLSTQLASGLRYLDIRARLRDDELHVYHANGYTGFSYEQVLLDVFAFLDAYPSEAVVMRVKEEGGPVGSNNSVSFEDAFRHHHWSSPATAPGSAKHLHEYDFAAPIPTLGELRSKIFILQNFDARDGPYGLLWEGPEMVLEDLWVIPDVYHLSEKWTAIRDALEYAALSPDDNRFLYLAHLSASVGVLPIEAAAGPMNRTIQGMNDMTGQYLEDASGNDDLARVGVVIVDFPGRRLIDSVLKWNAWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C602</accession>
    <name>A0A2T4C602_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1391495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C602"/>
    <dbReference type="OrthoDB" id="4896814at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="289" mass="32522" checksum="9B27FE4C632B64CA" modified="2018-07-18" version="1">MVESLPPPRFEISDCGLSESDPRYAAAVKCVQTYWKQATRMTEAQILRYLDYLNRKNIADFIPISAVTAEPDSVMARASTHELYPRFSVQGTLPNNGDFWTGYMLLSSLYEKLPPEYLRAIKKRFGSTTIGDHTDEYRHLYPAPAVQREIVTPVSNDDLRRLFNIPEAAEASTSTPSTTQSAAPGAWSIGNIIKTMSPSNRKRLGSGPESAAKRAKADNNEMLKKVNQQAEIIQEAIESLQEKQETKLQEMREAIEENKQAVTTMQGELRQFMSAVATTLRDIQERLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Q6</accession>
    <name>A0A2T4C6Q6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p20 subunit of caspase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1330710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Q6"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Q6"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="341" mass="37368" checksum="EF105C3343E4BE8B" modified="2018-07-18" version="1">MPPPSGYNQGRPNGNPPPPPNGPQSFGQGAPQGYAFRYSNCTGRRKALLIGINYFGQRGQLRGCINDVRNMTAYLVEQFGYKREDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEPDGYDEVIYPVDFRQHGHITDDEMHRIMVSPLQAGVRLTAIFDSCHSGTALDLPYIYSTQGILKEPNLAKEAGQGLLGVISSYSQGDLGGVANNIIGFFKKATTGEDAHNRALATKTSPADVIMWSGSKDDQTSADATIASQATGAMSWAFVTALRKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLSKSPLQICQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6W5</accession>
    <name>A0A2T4C6W5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1400201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6W5"/>
    <dbReference type="STRING" id="983965.A0A2T4C6W5"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="34140" checksum="C85C1EFB0BBF15D5" modified="2018-07-18" version="1">MSPSAYTETAATGERPSRPLARGIYVPTVAFFDPETDELDIKTVSRHAVRLAKAGVAGLAVQGSNGEAAHLLHDERNAITKATRAALDAAGFAAMPLIVGCGAQSVIEAVSLCRQAAAHGGDYALVLPPSYYAGLFDVATVEGFFVAVADASPIPVIVYNYPGATPGIDINSDVLVRLSRHANIVGCKFTCGNTGKLGRVAAAVRKSGESFLCFAGSADFTLSAHASGAAGVIGGLANVSPRANVKLWQLAEAGADKATEATELQAVLAAGDWVAIQTGVVGVKAAMQAFFGYGGWARRPLPRPDEVKVKGIEEGMREMMEVENGLPDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C725</accession>
    <name>A0A2T4C725_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1390669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C725"/>
    <dbReference type="OrthoDB" id="10671630at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="207" mass="22734" checksum="FB4F581011DFF424" modified="2018-07-18" version="1">MDSQNIAETPSSSNMVPTAGFDRIRPRRMPPGPRVRAMPTHAKICPWARLRTGCYCISRRETSELSAGVDSDLSGRNAFHDFILLSGVELQAFSSSWYRDSSARCLHGRTQDSGTPLEALRYASDPHHARLRTELSPQVSSKRTKKSTLSMPTGRALLCRCSGEGSGGKGHFQSRGRFLQPHRLAMPDALVGQDGSYESVRTEADIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7I6</accession>
    <name>A0A2T4C7I6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1400425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7I6"/>
    <dbReference type="STRING" id="983965.A0A2T4C7I6"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="509"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="890"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="903"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="985" mass="107337" checksum="29CA8FBFBCFF8E34" modified="2018-07-18" version="1">MASFLRSKQAGIQNDLSGSIRPELFAPDDHARYGLNSQISCFAYDPVQSLLAIGTAESKFGAGKIYVFGQQRVQKTFEPPRRTSFRSVQFSANRLVSLDRNNELGLWDLDTGERVAAQVIGGPVGAMVTDPMLDWAFIGMHNGDVVAYDLDRHMLARAFRLPNFWKARDPLQLTVTLVTLSMHPRDAGKLLIGYSHGAVIYSFKQNQPQQFLEYVLPVGAPGGNSVGMDTVRRPRLTHAMWHPSGTFVLTAHDDGSLVFWDPKEAKVIMARTLTEMGIQHATPSAPTTAYSDPYVKIAWCCKQNCDDTGLLIAGGQAPDASPKSLTFIELGMTPIYATSTWQGLENHFRGKRHISLNLPPGAQAVDFLLFPRDSPYFGGAQDPIAVLVLLTSGELITLSFPSGYPISPTNQLHPSTFFVHPFVTKFNVSSVDRPRWLSMVEKRDQGEPLLKGGAAGVRPRKRFEDRTIIQTAHADSIIRLWDSGHADQIENEVQLQVDMARALDRFEDVEVTAMSMAGATGEFVAGTKTGEAVVFRWGVNPFYGKNQSKQLDPNPMGLTDISSRAEPNLKEGLQPFVLYEMMQGPITAVRISNVGFVAIGSELGFLTIIDLRGPKIIFQAPMTEFAKPENRKGFLKGHSRSSSAPLKEWPTAMEFGVMTLDDDKYSSICCFVGTNLGKVITMKLLPGAGGSYTAEMAGMVAFDGRVVSLNPIQADTGKPALATGQIVAGLREGRQVHGALVAVTEKEIRILKPAHSKGASKEFDDVLCDSACVAELELQGYAIVAAFRDGSARAYSIPAMRDLGSAKLPMVDRTRSTATIVTQTGDIFAWAGPAEMAVVHVWGTGKELQQSPDLLINPKIDIPPRPTISNLQWISGTQHVSPLDLDLLVGGPNRPPSKRMMEAAAAEQRAASSTSAAGGGSSSQAEGWGDYLTRQLNERTEKLNLMGDTMDTLQEQSAGWADDVNKFIGRQKRNMIVGGLTSKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7S0</accession>
    <name>A0A2T4C7S0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1390893</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7S0"/>
    <dbReference type="STRING" id="983965.A0A2T4C7S0"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="21"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="349" mass="37525" checksum="989FADDA3C0DA128" modified="2018-07-18" version="1">MAVNNLSIVLAERPTDDIVPGTTFAQKVTPAPTPADLKDGEILVEALYLSLDPAMRGWLQDTRSYLPPVQIGEVMRGASICRVLASKSKQAAAGDFVCGFTGWTQYAILREGSFEPSANYPGLRDPKDMLSVLGMTGITAWVGMTKIGEPKAGETVVVSGAAGATGSVAGQIAKLKGARVVGLAGSDAKCKWLVEELGFDVALNYKDADFKQKLAEATPNYIDVYFDNVGGEILDACLARAKEHARFVMCGGISQYNTSKPQGPSNITKVITMRIKMQGFIVFDHIKDYPKARQELSQWMAEGKIKKTEHVLKGGLQVAEQGLVGLYKGTNTGKLLVEVKNPDEPPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Y7</accession>
    <name>A0A2T4C7Y7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1330138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Y7"/>
    <dbReference type="STRING" id="983965.A0A2T4C7Y7"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="179"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="536" mass="58715" checksum="47B3ED6CBD6321F2" modified="2018-07-18" version="1">MFMEAAVPNVTRASSQKGDVGIWFPSTTTSQPSQFITSRPPPVMDGFMLPFVREHCLTCLPPDADYVRLKRVFLQKVHPIFPVIPVAALDGPTDNPANIVLRQLACLAAGADPELTPFLRLNNKGPNPLRPAEFSSTLSSSVRAILETSLIPDRVVHIQALTMLSLYTQPTCAEESDLPAQLGGRAIHHIQTLGLHLLRYDGPNFSDLENLFCAVWALDRINAAMYGRPCLIHERDIGADLEACIKKREPAFRLLLSVAQWLDKVVELYRPGPSAQVSGFDKVAYIDLPVLEAMIVDADALKVPTSLIATIETFYHAVIILSCRLPRPGTRIAASTLPPPSANARRSLAAERIACAVPRDCLSSFPFIPYAVSLALSVEYRKMRHSRLPMFRARAMSAFKRNCDLLRTYGDHYWSAGVVAGLGEGVLREMERAANTLAKDLSPQPTEVQPKPTPKNQDSSTPQEAGPTPSGEAPPLNHTMGYDNVLDFSVIEAISGQDVFGHIDPNFNLDAVEDALEANLDIGLPPNWGDWGQFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C834</accession>
    <name>A0A2T4C834_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1329966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C834"/>
    <dbReference type="STRING" id="983965.A0A2T4C834"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="12695" checksum="D63B1451D3FFCD5F" modified="2018-07-18" version="1" fragment="single">HSGRNKKGRGHTKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFAEYTVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRVRYNKDGKKIVPTAAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8G7</accession>
    <name>A0A2T4C8G7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1330621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8G7"/>
    <dbReference type="STRING" id="983965.A0A2T4C8G7"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="288" mass="31294" checksum="A958CC3F7E11B55C" modified="2018-07-18" version="1">MGSSNLKDNTTLRILRAADQGNYGVLAAVGYNLEQILGFVRAAERKRSPLIIQLFPWAIAHSDGVLVHAAAQAARQASVPVAVHLDHCQDEAMVRRACELPFDSIMVDMSHHSKEENLARTRELVAYCHERGKAAEAEPGRIEGGEDGVSDTLDLEGLMTTMEEARGFVDAGVDLLAPAFGNIHGEYGPRGIVLDFERLKQVHEITKASNVLIALHGVTGFSEALLRQLIDAGVRKINVNKDILMGYYAVLEQKINKAPFTQVVDEAIEQVAETLARQMDAVGSSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C987</accession>
    <name>A0A2T4C987_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1329441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C987"/>
    <dbReference type="STRING" id="983965.A0A2T4C987"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="415" mass="44139" checksum="53FBB7571FE3C3C7" modified="2018-07-18" version="1">MSPPVTSDPVTTPQRPPTPVHAFGTLAVHAGSPIDPATGAVIEAISLSTTFAQSAVGKPVGIYEYSRSSNPNRDNFETAVAALEHARYALAFSSGSATTANILQSLAAGSHVISVSDVYGGTHRYFTQVAKAHGVKVTFTPEIEVDIAEHITDQTRLIWIETPSNPTLRLVDIRAVASVAHKHGILVVVDNTFLSPYVQNPLELGADIVVHSVTKYINGHSDVVMGVAAFNSDNLKARLSFLQNAIGAVPSAFDSWLAHRGLKTLHLRAREATKNATTVAHALEASPHVIAVNYPGLDSHPHRHIALKQHRDGMGGGMLSFRIRGGHPAAERFCQVTKIFTLAESLGGVESLCEVPSSMTHAGIPRDQREAVGVFDDLVRLSCGVEDAEDLKNDVLQALELAVAFTNGTNGANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9H8</accession>
    <name>A0A2T4C9H8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9H8"/>
    <dbReference type="OrthoDB" id="4894022at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="37147" checksum="6574AEA7FCFDD0DF" modified="2018-07-18" version="1">MFSDPFSEHNGVHRAKSQGTLRIEQHLLPSDYHVYPQHPPSSFASGLRPVMSKETMCEQIIKYDCGHMCRRMIPCIEREPKHHHSLTCFSALSLHSYEPERHETPRLEVRATLCPMCEEKGEGGKVYVNGTRRASVPQFGTRQESRSVRQGEKSIATKVSAGVGRSVSNPVRSPPPRLRRVRDTGNSSLRNEYHRLEPHLDPRSAPRPKPRTASHTEHPPGARLEAPRNPGFAARRGQRHRPEDIMTQDLDLDWFASSMVPLSERSPTSPTSVTGLLDYGQGNRNVSAMSLGRLSRSTSVFKMLQKGLQRQPSMESFVCASAREVERGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9I0</accession>
    <name>A0A2T4C9I0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_50582</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9I0"/>
    <dbReference type="STRING" id="983965.A0A2T4C9I0"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB78210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="328" mass="37647" checksum="7AE2EFE012527BFD" modified="2018-07-18" version="1">MPISVRDTKAYRADERYGHALLTEAQRQAIFKASLPAPNDGPAGINGKGAQVQRRSRLGVRRFLKNQVFVFVFALMHGIFSLYIKSRQTWHGVAYQISSILYYHHATPQYIRRDVEGLTKKPKHLSAILKTEVDHRAKTDIDRLIEETAELATWCACAEIPMLSIYEKSGVLKKHMPRVYEAVIQKFTFYFGAEHPTLSVTSPHRDDFPTRMLEESKHGHLQLHLISYQDGRESIVDLTRTLADMSQRGKISPRDISQELIDAELSEGILPEPDLLILFTPYVELSGYPPWQIRLTEIFCLQDNETFGYQVFLRALRNFASAQMRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA27</accession>
    <name>A0A2T4CA27_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1191700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA27"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18191" checksum="A3B3E5E4319632E0" modified="2018-07-18" version="1">MSGQTAADVFGRRRSTGERPLDRASHQTAERRSRKRKERESEGNGTLQGSIQQLRFCSNMNVEAPTGFRRAGFLYLGAARVRAPKVPASLGRARNDTSLACVLTRSGNASDLAFEWTLHGEQSRAARRIRPRTRSGAMQTKLHSCSQVPGYGAELRLDRTWWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAT5</accession>
    <name>A0A2T4CAT5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1328680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAT5"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="473" mass="51256" checksum="B3501541C9DD3459" modified="2018-07-18" version="1">MALVNSAIDEIGMTEFQWKLFFLNGFGYAVDSLLVVCQSIANPAVQQEYGLPDAHVSGIPLASQVGLLVGAGIWGFSADIIGRKLAFNTSLLSCAVFVLVAGGMPSYISFAAIVAIYSAGAGGNYVLDATNLIEFLPTTHSWLVTFMAVWWAVGYTITGLLAWAFMANFSCAPDATPQTCRRADNMGWRYLHFTCGGLVLIMAIARIALIRMTQTPRWLISQNRDEEVIKTLNDISTKAGRSHSLTLDRLRAEGIVLHTEQSVWAPLRLKMHFKGLFQTRRLAWSTAVILSNWFVIGMVSPLYSVFLPFYLQSRGAVVGDGSTYATWRDYAINQVAGLIGPVIAAVLIETKFFGRRGTLAVGALVTMVLQFGYTQIRTPAQNVGVSAAISAASNIYYGTIYAYTPEILPSAHRATGYGLCVIVNRIGGILGVLVGSYANVETTAPLFVCAALFGLLVVLSLILPFESRGKRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB05</accession>
    <name>A0A2T4CB05_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1461779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB05"/>
    <dbReference type="STRING" id="983965.A0A2T4CB05"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="501" mass="58659" checksum="2DA5D29155A84CC8" modified="2018-07-18" version="1">MLVLEEQRYIHEDLERLEQGIADRMREDPKHIRDRLNRDHEVAQLLDQIQAQSQNLINIYRDEDGSRAREIQQIGTGDPFEEFYRQFKDVREHHARYPNEQAENSEQRYKVSKHGDPSEPLPSIVDSLFTGEEAYGRFFDLNICHESFMNLNNVKRLSYLQYLEQFDNFAPGYGGVKRNEKLNDQYFKYLGELSDYLESFMRRTRPLENVDKVLQTFDKEFEEAWAKDEVEGWTLEQAAQPKQHTGDAIWCDDCEKEFANENVYKNHLKGRKHIKAAEHRAQRQADSAPSANGPGKGAVSTHRLKERAVAEREYRIKRLASAMSTERSDTRVNVERKQGMTERERQQELENLLNAGETRYEPMDEEDGEGEDGEEKIYNPLKLPLAWDGKPIPFWLYRLHGLGVEFPCEICGNFVYMGRRAFDKHFNEARHVYGLKCLGITNTSLFRDITGIDEAMRLWEKIQKERKRGKIDDGSVIQMEDGEGNVMPEKVYYDLQKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC42</accession>
    <name>A0A2T4CC42_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1452655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC42"/>
    <dbReference type="OrthoDB" id="10506922at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="16137" checksum="88E3704EDC075E13" modified="2018-07-18" version="1" fragment="single">ISQTQRSSEPPSDGLSCEHAIVKATKPVIGPLAAGNGDILCVFGVYKTGTMRAKAGAISGKGRRAARRRKTAFGGSAVVSSYGTLVIFCLVGQGSAALQPNARPGLASYGHPLGTTLPVLALALAFSSTRAVTFTSANQRLCNASPLPARDRTTFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCL7</accession>
    <name>A0A2T4CCL7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_233148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCL7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="107" mass="11925" checksum="40FDE439467FCB94" modified="2018-07-18" version="1">MRRLSFTPIVFLRPGSGSLTVSPSVDQVPLPCCTITIRMYSRRPSSKHKVSEAGIHVKHFDDGLLQRSANKNPSLRKTNVKPAHKSTFAIVAIVNQRGIPMRSEIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCN8</accession>
    <name>A0A2T4CCN8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1398583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCN8"/>
    <dbReference type="STRING" id="983965.A0A2T4CCN8"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="411" mass="44877" checksum="F3B956787DF01269" modified="2018-07-18" version="1">MSETKEVDYSLNNPDTLTKYKTAAQISEKVLAAVSDLCVPGAKIVEICQQGDKLIEEELAKVYRGKKITKGFSHPTTVSPSSYVTPYTPLTTDESEASIEIKEGEPIKIQLGAQIDGFGSIVCNTIVVTEKDKAAEPITGRTADLILANHYVNEVLLRLMVPPGLLAQGTDEEKAKAAAQKAPTQSKITSLLEKVCDAYECKLVESTTSWLFDRNEIEGSKKIVLAPAEGTKGEGVPEVGEVWGVETGVSLGSGKVKTLDQRSTLHRRTNQTYQLKRPTSRKILSEVQKKFGTFPFSLRQLEDERDAKAGVVECVRNNVFRQYELVGDKDNAPVARLLTTLAITKNGITKLGAAPELDLSKFQTDKKITDEEILKILEQPLARNTGKKKSKPKKKAAKADGATEEAANAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCQ3</accession>
    <name>A0A2T4CCQ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide chain release factor eRF/aRF subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1371215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCQ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CCQ3"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="494" mass="55036" checksum="3D6F35031F4471F1" modified="2018-07-18" version="1">MSDPQAGEAEKNIEIWKIKKLIKRLEAARGNGTSMISLIIPPKDQISRVAKMLAEEYGTASNIKSRVNRQSVLSAITSTQQRLKLYNKVPPNGLVVYCGEILTSEGKERKVNIDFEPFKPINTSLYLCDNKFHTEALAELLESDQKFGFIIMDGNGALFGTLSGNTREIVHKFSVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAELAVQNFITNDKVNVAGLILAGSADFKNDLNASDMFDNRLAVKVIKVVDVSYGGENGFNQAIELSSETLGNVKFIQEKKLIGKYFEEISQDTGKVCYGIDDTLKALELGAVETLIIFENLEITRWILKDSEGNEVILHTTKQQEQQNREKFLDKATGQEMDIVSQESFLEWIAEHYKDFGTALEFVSDRSTEGNQFVKGFGGIGGILRYKVNFEQLADLEDDDDDYYDVNPSAHDDSGGPRDPSGSGDAAPMSFAQRRLMRGPGQVPSHQAHQATRPSPLRANMTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCU2</accession>
    <name>A0A2T4CCU2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_237287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCU2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="102" mass="11504" checksum="49C6294EA0117CBC" modified="2018-07-18" version="1">MHTKDVGVAIFFVSYFCFCFFAFFFFSPLASLGVRKHESLNHILTYNYRDQASRTLLDFVPCALPGCLVPRAPSTEKPDKQQTVDVVLLSCPAEQYSSPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCU4</accession>
    <name>A0A2T4CCU4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1326239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCU4"/>
    <dbReference type="STRING" id="983965.A0A2T4CCU4"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="339" mass="37346" checksum="7BD0BF8E697FFE95" modified="2018-07-18" version="1">MPVQLLPASAAAFAPRASSVNVVLGSRVEPWLTQTLKRVNRVKRPLNSVPQHQRCLTELLSSPNAIWTLCSIMLAKLPQAEMPEDPTENLFSHQLFHIEAYIVHVDMVLRNEVAFKLTTDTIDALVEYHKEVHCVDAKANTYDWSEKEQQCKKLHEDFVQAINKFVFRADVSALEGLEEEGAGELLNGKSKDVKASIMNLMKPLLPPPPRVVEVIRQPPLLPSSPLGNMWTQAPPHIIPAAVEPWQVLPSSPSVTSSVDSSNTPLWANMGMSDCQLPSPTPSFSLPQTTAELFYSPPIMAPIPALPLPSVFAPSQCGVSLGMGIGGFGWDRYHEYATIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCW9</accession>
    <name>A0A2T4CCW9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1371298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCW9"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="437" mass="47542" checksum="BDE174B1E5AAF3EB" modified="2018-07-18" version="1">MASRTASQHEGARVPLPGQIISVTISLAATTVLTLFLTKRVVVIKAWRRLPPVVWLVFAIYVDSYAFVVATAVLQHSIGVNSSYGICEAAIILCLVCYVTTKVRWPAFIYLFLAEKAYIIRGATMPRLRSKLYLVNSLGMLTIYVAVVILNFVFRITAMEDGECIIGMKTAAMVPLISFDTVINVYLTIMFLIPLKKLYSFTNMPRTRANIRLRMAAFRTFCGAVCTLVSSIVNLSVLMALNGEPGWVCLMCCNCDILFSAVVVQWVTSKDNAGTVSSNSSGETRRSRDFGPGINRISTPSELHETPLSTLTDISLVPSRRRSPVTDNVDPHDSGSPDGGTDKVADKPSSAVLVTTTIESETRPRSYSFIGPPRESLRECGCSCLRSRRPSMAADGGLYSPQARIAAGGLHFPGEFGHKADAYYCQPSGPGETHSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD11</accession>
    <name>A0A2T4CD11_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1419785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD11"/>
    <dbReference type="STRING" id="983965.A0A2T4CD11"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16067" checksum="E9B3F022B3D88851" modified="2018-07-18" version="1">MPIVWPELHRDGTPCGSGGHCSNGECEGTSTAGEIRDWITSHKDIVIPIAVVVGILLIIVVVSGIISCCRRARRRAAPKSSPTAAAWTQWGGNNNRSAAPQYGMNDLQQQYDPPPPAYGQQQPPEYGQPPPPPPSDQQWRPRMERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD55</accession>
    <name>A0A2T4CD55_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1371443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD55"/>
    <dbReference type="STRING" id="983965.A0A2T4CD55"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="149"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="337" mass="37566" checksum="24ECE5A417549163" modified="2018-07-18" version="1">MMKIQRLFIYPVKSLLPIEVSIAEITSEGFRFDRQYILVRDPRSHPTIRPHLAEHLTIKLVYKLALFQPSIDDDWSELTIKHRTAQPESSITIPLTPSPLSCLEAPSYQVSIFGTEATGVDMGDGPAEFFSKHLDIPTRLLYISGSGSREIPGAAYIPKHRLPLTIRAAGDHFQPQRIRFADAAPFLVTSTASELDVRSRLPPENQQEDVLLRFRTNIHIDVGSVAPFDEDNWRELTVFAEDGTTPKAIIRCVFKTPRCLSVNADIETGTGSPRSTQVYGLIARDRRVNKAYPLKPVFGQWSFAGPNGALLRVGDEVRVTERGANDSLSENGSTSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD63</accession>
    <name>A0A2T4CD63_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1398801</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD63"/>
    <dbReference type="STRING" id="983965.A0A2T4CD63"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000006">
        <property type="entry name" value="DNA replication complex GINS protein SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="11">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB79511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="221" mass="25161" checksum="2FD2012F7D5C9ED2" modified="2018-07-18" version="1">MDIDDILREVDPASHGIPLETRDLQALTRLWVAERSAPELLNWPADGLFERVNSKIKSQIERIEDMTGDMDPKTNFALIVIQTELERYKFLVRSYLRTRIAKIDKHTLHYLSTEALRQRLSPTELAYATRHQALLHNHYLSSFLSSFPQRLQNLNDTAGNVSMIDNPDLDTAVFVRMLRDKDVFGRGTDVDTILPAANGDVLIMRWSSAKGLVEDGDAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDC5</accession>
    <name>A0A2T4CDC5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1327276</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDC5"/>
    <dbReference type="STRING" id="983965.A0A2T4CDC5"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="47"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB79553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="197" mass="21733" checksum="5AFA186F601286A6" modified="2018-07-18" version="1">MSPGMTLFAVQAILILGTEDGARIFAKYFSPPHAAPTGGASIPSHPYTDLKAQKAFEKGLIDKTAKQTGDIILYDNRIVLYKMESDVMLYVVGAADENEILLYNTVLALRDSLHLLFKQSVDKRTIIENYDLVSLAIDEIVDDGIILETDPTIIVQRVSRAPTQDLPVGRIDFSEQGVNNLAQLGKSKLSDWLRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDL9</accession>
    <name>A0A2T4CDL9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1436899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDL9"/>
    <dbReference type="STRING" id="983965.A0A2T4CDL9"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19146">
        <property type="entry name" value="AKR_AKR9A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="380" mass="42403" checksum="3DE3623978581943" modified="2018-07-18" version="1">MSFFPAPPPPVSPLNRYRLLSPTASVRVSPLCLGAMNFGSAWKDFMGDCDKATSEAILDFFYEQGGNFIDTANNYQYEESEAIIGDWMKKRGNRHEMVIATKYTTCYKLGPARPHIAANFTGNGTKSLHASVEASLQKLQTDYIDLLYVHWWDYATSIPELMQSLNSLVVAGKVLYLGISDAPAWVVSKANEYARNHGFRQFSVYQGRWSAASRDFERDIIPMCRDEGMALATWGALGGGKFKTEEQRNSEVGRKVQATEVDIQVSKVLERIAARRNTALTSVALAYVMQKTPYVFPIVGGRNIDQLKSNIEALTLQLTDEDVEEIEGAYPFDIGFPNNMLWGGVRKSGSSPQKIWLLESAAHYEYIPEPKPIAPTKIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDV9</accession>
    <name>A0A2T4CDV9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate-binding module family 48 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1389688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDV9"/>
    <dbReference type="STRING" id="983965.A0A2T4CDV9"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="359"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="471" mass="50199" checksum="B7ED67A9C0A6A70A" modified="2018-07-18" version="1">MGNNHSASNKAGGPGSPPQQQQQQQSDAVDSPRQPHHRRDGSRNVIPVHAARAAAAPEPSSLQAQGSIAASVPKPKNLPATAVSSLSGSPHSSNVSSVANAAAAVTAAVAAGSEKPSEPRPIVRDEPSKPVAVPIEGSVARPHIPAVPPYLESQYFSNNSLTDMYMMRPPRLPLPIEEEVHTPGSPILGPDETFADLDLGESSDGLTRKSSALSAGTAEDEEGEELRVDKTRPVVATRIEWRGGGEKIWVTGTIFHWNRKLRLRPVEGQPGVFAATVHVLPGTHHIRFLVDGIMQTSPDLPTTVDFGNNLVNYIEVSPEGASAAKQSEAAKAADAEKNKGEPRTDAQSKEEPKVPRGKPVLPAEAYTSEIPQYLLDFDQPEESPAYRNAVSAIEKLTTPPSLPGFLGKPILNAATLMKDDNSVLNMPNHTVLNHLATSSIKNNVLAVSATTRYHNKYVTTIIYKPTSADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE14</accession>
    <name>A0A2T4CE14_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeodomain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1327077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE14"/>
    <dbReference type="STRING" id="983965.A0A2T4CE14"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12451" checksum="DCE6E2458CF00F32" modified="2018-07-18" version="1" fragment="single">MRNGVLSPKKGPWTPEESQRLVTLVRLMGPQDWVSIASFMSSRNAKQCRERYHQNLDPSLRHDPISDDEARAIMDLYGRYGTAWARIAEHLPGRSDNAIKNYVNGLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE83</accession>
    <name>A0A2T4CE83_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_63665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE83"/>
    <dbReference type="STRING" id="983965.A0A2T4CE83"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="486"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="583" mass="64127" checksum="CA921DE5026EEBB3" modified="2018-07-18" version="1">MTPDLTSDQLLVNTQHIHPTKSATVELKAPSYDLARHVSDEILLRIFSYVDEHTLLAASAASRQLYRIASDPQLWRVHYYQRFILPRADRIPGLKLEPEAAGQGEPQATAEANAAQASDASSGRLAPTSAAHADAEPAEPFKPADPADKSGRLIDYVDWKQQYRLRHNWARGLCEVRQVEVSPINCSLAPVLERRTLVKVVHGIAVTVDLQAGLRAWDLRTQLSIAQTTTETHDGIRLVPTALSLDGQKFEAGILDIMLGFNDGTFGIWRLTIGQGKLAVLYRQDKSYVGRLTSVAYSYPYALTAAELGFISLYTFDSPAPDNNELSTLQAGGEVDKSADLSHPFVLSSLKSDYSRQPLVLSLRQLKDSAVASIAYSFDTVSGWAIGIQNFDIRPSGCSKPDVITSRVAYTLPADTRGLVAPTHYRPKCPTCANFPDTYLDDDEGGPAKLCYSHPYLLATMPDNTLVLFVVTATEKSFAISNPTRLYGHTSGIADADVTPEGRAVSVSERGDEIRVWDLEGGHRDVSVEVRPRPGREADDVEDEYTSSEAEQRRNWVGTDDQRVTVLSETLDGRESLVTYDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEE0</accession>
    <name>A0A2T4CEE0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_174437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEE0"/>
    <dbReference type="STRING" id="983965.A0A2T4CEE0"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="18"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="598" mass="67814" checksum="D82B95A3A91E9C42" modified="2018-07-18" version="1">MTVPGRLKLWWKHAIIYQIYPASFCDANGDGIGDIPGITSKLDYIAHLGVDVVWICPMYDSPQVDMGYDISNYEDIYPPYGTLQDMETLIREAHARGLKIMLDLVINHTSDQHPWFQESRMSKDSSKRDWYIWRPAKHSPTGERHPPNNWRCKFGGGSAWEWDEATGEYYLHLFAKEQPDLNWENPITRKALYASAMEFWLERGVDGFRIDTVNMYSKPPGLPDAPELDPGAPYQAADMLYCNGPRMHEFLGEMNQVLARYGAISVGELPSTPDMARVLQYVSAEAKQLDMVFQFDVVNVGFNKPLRYDAKPKDWQLPELKRAIARTQTLIKGTDAWTTVFLENHDQARSITRFADDSPQHRVASGKMLALLQACLSGTQFIYQGQEIGAVNVPEDGYPLDNYIDVSSRLYLDFVREHRNGEGLAKAHTSLAHFARDHPRVPMMWNGKAKYGGFSEEAEKSGKEVREPWMKPHPLAEQIDVASQLDDPQSVLAYWQKAVLFRKQHADLLVYGDYRTLREGDKDIYTFVKEAPSGGPPKAVVALNFTGEEKEWERPTAGELGIEDGADISCVLLMSSYDGKVDEGSLKPLEGRVYLVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEM9</accession>
    <name>A0A2T4CEM9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEM9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015424452" evidence="1">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="131" mass="14690" checksum="9CAFFA64F062E4D8" modified="2018-07-18" version="1">MASWSRSMSSWFPWSLVVILVSCSSCDPEVQHVPNHASLRWSATNRSRPFLRPDAPKGEMLQMSGFHGADTGLLALSYRAEDIACRSCSTVSLPTRYQLLASYRFRRVGNEIRLKPDRQGTSRGWAVFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEQ7</accession>
    <name>A0A2T4CEQ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">POPLD-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1460092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4CEQ7"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="128"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="627"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="809"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="873"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="998" mass="111497" checksum="24C3A9D15041ACC7" modified="2018-07-18" version="1">MRLRLSRYAVGKELPIIYTVCEYCILPRLSIKHGKKVSQAKSITAHQTTSAKWQTELRKAPQLAIEMAANNSTGGQSASASKKRGPPAHNARSDAFMQKRAKVHAARSIPTQAAEAALKDGELDLVAFVAAHEFEIRALEQSMATTKAVKSSRAFQQVPRGLRRRTASHNPKRVPRRLRARARKEMDEDNTPLVESRKRKPRTTRARIRAQTAKRLRILSARKKKRKQKKSQQPSADENQRDPKTSTATDAVERASRPKIRRNAINEPPRPAAKFRKRQMNKTWLPTHQWHAKRARMTEPTEPLWRFAIPLTPNEKIYRPTHRAQGERGTMVWDMTYVSTIGLYGNFAGMERVLRRIGVTNESCWDDRGAKWRQGTRAWTGILSRERAGVKRSICQSTIIWDPEAPSQLIDEDRAESEGEQRSKVDKKTQKRVFLRVHPSAFLELFNELLRLIKMEKPQLYIEDLRFEIGSIELSGPASTEALLSVLTPYPSGGSNPKNKHAELFESLKGLTNPAALPGNSVLHFAVQDPRLRYPPRKMEFPETEQAEMDLLATIASWPAEENLQPSLLFDRHARHRASCLPSQKSINRRRSKATSGALLKPTIHDPPIPVTLIASRSAPGTQAQGTWTLLAPWKCILPLWYSIVHCPLVSGGNPRFGGLNETMQVAFERSLPWFPADFLGTDAGAEWELERRQRRRRDWARRPKSKRVEWTSLMLGAGRQGEIGDGHACDFEFLFGLAQQQQQQQQSAAPDGSGEAMDVDDENPAPTKKKGKDVAIPYLKLLNSIPKSVFDSLLSPSPPLQPLPPYAIACVRISLLSRGVVNPCARIYRLPSDPIPVPPSSDAEVPASMPPEASSLPSDLRSQWLSRIPSYSSSSTWSKAKPSSSSNRRASRLDDMEARKRILAQELLTAPPSLESVLGPNEADIGGHHPLVPDAKDLVGFVTTGSFCLANGRGAAIGSIAVVRVLEDVRANPREGRLCIVRNAGENVGWIARWDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEY3</accession>
    <name>A0A2T4CEY3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_181067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEY3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="73" mass="8574" checksum="222C41F1064A76E7" modified="2018-07-18" version="1">MKFPTRYFPSPLFHLMAQALCCSHHRRFLAIVLARSQDSPIQTPSNADRQHLEYQSSREDTIKIHLWKNHGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF01</accession>
    <name>A0A2T4CF01_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF01"/>
    <dbReference type="STRING" id="983965.A0A2T4CF01"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="14908" checksum="68BB8A6DC0F3B88E" modified="2018-07-18" version="1">MPRQRSVGRAPSRPTASAPKPQQQRPATTMAAPPQQHAPTNMMPPQQASQGPGLFGQMASTAAGVAIGSSVGHAIGGLFSGGSSEPAAPVQAQAAPQQNQQQYNNCAGAAQNFTKCLDENGGNMQICNWYLEQLKACQAAASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFB6</accession>
    <name>A0A2T4CFB6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_188490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFB6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="15094" checksum="B87DCF317BBC2853" modified="2018-07-18" version="1">MRSDMELLRSGGSGAQPPDRLRRRLRDRAPLLAPCSLSCASLRLSLTEVFHGIGCSPHDETRHRREFFICIWGSCIIGRLSFQQPLWFLGVFCFILGASSSLLPQHWFRGEAGPALLRCRCALPCSAHTWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFG4</accession>
    <name>A0A2T4CFG4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1121740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFG4"/>
    <dbReference type="STRING" id="983965.A0A2T4CFG4"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="463" mass="51350" checksum="07760B7F860566DD" modified="2018-07-18" version="1">MEEIAKEYDVIVLGTGLTECILSGVLSVKGRKVLHIDRNDHYGGEAASVNIETLFKKYGNFKDGEKPWEKYGRLNDWNIDLVPKFLMSSGELTNILVSTDVTRYLEFKQVAGSYVQQGSGPKATVAKVPSDAAEALKSPLMGIFEKRRMKSFIEWIGTFDPKDPATHKGLDMNTCSMKDVYEKFGLEDATKDFIGHSMALYLTDDYITAAGKAPEAIERIRLYGNSVARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTNIDEILYEDGKAVGIKATMTGVEEMKFETRAKMILGDPSYFPDKTKVVGHVLRAICILKHPLAGTNDSDSAQIIIPQSQVGRKNDIYIACVSSAHNVCPKGYWIAIVSTIAETSANHHLELQPGLERLGAIEEQFMGPPIPVYEPLEDGTKDNIFISKSYDATSHFETTTDDVKDIYRRATGEELKVEGLREGINVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFJ3</accession>
    <name>A0A2T4CFJ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1435951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFJ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CFJ3"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="141"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="301" mass="34165" checksum="7BA5FF8769F802D6" modified="2018-07-18" version="1">MVATTCRGPLPPYKSSSGVCRCVVSYLPISDDDGCDIDEDLMEVGTIGFDRISQFHFYEVCRSGDFLRSFPFCFNPKLSFLKPQHVITAVRLEQFAFEHSQRGFSSPLAEYRIRFSGNLSYGLFNICDMTERKNWWVATKMRGWNIDGCPEDVRRLMFVHIIATLGCSPFVTDEDMDYPKNWAAILNGRERYPSEPVGHRPHGRTICLHSVAVCPRLQGLGLGTATLKSYVQRMNSLGAADRVALICRKPETRFFERCGFKNIGRSTTKTLVGEYYNMVFDLPGPKDFIDWNSIADAAKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFR7</accession>
    <name>A0A2T4CFR7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1124871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFR7"/>
    <dbReference type="STRING" id="983965.A0A2T4CFR7"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="34"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="414" mass="45741" checksum="7277A325F9EEFC38" modified="2018-07-18" version="1">MASTTSFPPETVPQAPEDPLFGLARAYKADNSPNKVDLGIGAYRDNNAKPWVLPVVKKADDILRNNPELNHEYAPIAGLESFTSKAAELMLGADSPALADRRVTSVQTISGTGAVHLGALFLAKFYKGNRTVYVSNPTWANHHQIFNNVGITVAEYPYFNKETRGLDFEGMTAAISAAPERSIILLHPCAHNPTGVDPTLDQWKHLAAIIREKKHFPFFDCAYQGFASGDLARDASAVRYFVEQGFELLIAQSFAKNFGLYGERAGCFHFVGAPAADAAETVTRIASQLAILQRSEISNPPLYGARIASTVLNDPQLFSEWEENLRTMSGRIIDMRKALRSKLEELETPGTWNHITDQIGMFSFTGLTEPQVMKLREEYHIYMTKNGRISMAGLNTHNIDHVAQAIRKVVGETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGE3</accession>
    <name>A0A2T4CGE3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1397966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGE3"/>
    <dbReference type="STRING" id="983965.A0A2T4CGE3"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="202" mass="21328" checksum="2A622C11EA2D363A" modified="2018-07-18" version="1" fragment="single">MAAPTEAQIAHTQLLEQLDIHSIHKNFRNPNWKPNQRRNKNLKAIVGDASKREASALATPQDVSGDATPAAVAAADDGLSTSGTSTPATGTNSGSNNNPLQQPPNLAQASRSLSKLVLEKTLRPPGAGGVSAAPSATYTNIESAPSLAHAKHYCDITGLPAPYLDPKTRLRYHNKEVFGLIRTLPQSSAEQFLAARGAHTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGH4</accession>
    <name>A0A2T4CGH4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine repeat protein-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1321107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGH4"/>
    <dbReference type="STRING" id="983965.A0A2T4CGH4"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49864" checksum="C2CDE522615D3A87" modified="2018-07-18" version="1" fragment="single">MYSANYGFGNAAPNFANPAGAPQPGMQPGQQFMVNRQQQFAGMAPHGAFPGANPHMMADASAAMMQAQGMPGMAPNNQMAYQQQFPGASYGQVLPAGVGPQGFVPNNYMMNPAMQGFPMGQPGMPQQAQQAQQAQMIQRMQQQQQQQQQQQQQPQPQQQMPQQQPPQQQQQQQQQQQPNPMMGQVSTPQRPPSTAQGTPTNIMPPQQPQFSTPQHMAQGQTPTNQHQQPMGVATPQTPTFSSNISGGMAAPSTAAAPMSPTTENLEKERFALLLDINHELLYESIQIQTTQQELKKEHAAMNGNVPDRKPTEEENLFQQDYLHCMRRLQANLSYMAALADRKPDVKGPPCPAYLSPPPLNLSLKLRATPIGAENMTTPIDTVADREERYKSIQDLYRRLQAVFPGFDPKKEPAFRMPSQKPPMGPMVPSQQASPAAQRTPQLPNMPGPPMNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGI1</accession>
    <name>A0A2T4CGI1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1398018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGI1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="63" mass="7132" checksum="DEE1897DA3DE2F8E" modified="2018-07-18" version="1">MAFPFSHALIVGLAHLFMATCRIRCSNWKHGSCCLLRVPQVFVVILLCFKSVRAARCTVFVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGL7</accession>
    <name>A0A2T4CGL7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1460537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGL7"/>
    <dbReference type="STRING" id="983965.A0A2T4CGL7"/>
    <dbReference type="OrthoDB" id="5357513at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="31850" checksum="3B1D3A8E15CE810C" modified="2018-07-18" version="1">MEPKASLLLYGTAWKEDKTARLTETAILSGFTCVDTANYPTAYNEQLTGEGIAAALNSGIRRGDLFIQSKFTPVWAHAKDKIPFNPHQSIEGQIVESVQQTLKHLQVDYLNSLLLHVPFEDDKDNLIAWKVLETFVPHTIRSLGVSNFNLSQLEGLYADATIKPTIVQNRFYKETRYDSDVRAFCAEHGITYQAYWMLRHNSEILASSVSNTVAAKLNVEKELAFYVLILGLGGTQVLNGTTDPGRMVQDSKIIGEVFGDEERLRELQTDFDEFRRLLTILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH43</accession>
    <name>A0A2T4CH43_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH43"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="82" mass="9089" checksum="A9D9FE9FFC59F37A" modified="2018-07-18" version="1">MTLGCPSQLLSITQVFHTPVVSLSTPRAWAARISNFAEGSLEGREKEESRSQREWASRKEEKPLDRLTVLAPAPKSPGRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHB8</accession>
    <name>A0A2T4CHB8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TUG ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_45275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHB8"/>
    <dbReference type="STRING" id="983965.A0A2T4CHB8"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TUG ubiquitin-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="509" mass="55489" checksum="2C892CFFE4574913" modified="2018-07-18" version="1">MSSHVVVIATDLRRTTVKVSPGTYLSDVLEEACKKLGLDSNKYLIKHKQKQVDLSIPFRTSGLIAGAKLELVQKSKTPSAVQIALQLPQPEAKEIPGGRLIQRFPSDLSIWQVLRQFESGEASGGKNVNITARGVAETAGGGSSGAGQLYYETPVLNIMGRELASLADFQKTLSQLGHNSGNVLIRLTFRRTDQTLYEAREQIGAFFKEEQRQAVSSAEQDKPQNPPADGDTPMAEAPSEPVDNSTEAQERKHASAQATEDATTTTSPPSDSQQTPKEKNSSEAKSRFQPVNVFLAPTNSTPAAALVPADDEDFTPTIAHAQLHQARLQESSRNRRLLSDKEIEEREAAEQAKIAAVKSVLIKVRFPDNTSSDWEVGPSDTGAFLYQAVRHVMADSEQPFHLVIPGSKTVIKDDDAPQHSLIRAYKLSGRVLVSLVWDDGVPAEVRKRPFLKADFAQQGQAIKVPEIPTVEDDVDAPSVLPQVQKAPEKRDGGEGSGKKMPKWLKLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHM5</accession>
    <name>A0A2T4CHM5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_15569</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHM5"/>
    <dbReference type="STRING" id="983965.A0A2T4CHM5"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="470"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB81067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="804" mass="90500" checksum="3B32F502FE2065EF" modified="2018-07-18" version="1">MSFIRSSLPSIRIGFPDPFAVATINGEQTKTTTVSKKTLNPYWNESFDFRVDESSILAVQVFDQKKFKKKDQGFLGVINIRIGDLIPEIGPDADDQMITRDLKKSTDNLVVHGKLILNLSCNLSTPIRAGQASSSRPALGAPSASNLSTLSAPAGDRPSSAMSGVNNNALVPQPSLSHHPASVNAVPSSSSVNGSQTRPTSQLSPFEDSQGRLPAGWERREDNLGRTYYVDHNTRTTSWNRPTAGGTAAETRNEREAVTQVERQRHQNRTLPEDRTGTSSPTLQQQQQGSGAGSPGGAAANNAAGSSSHTAMMHTGATSPGSGELPPGWEQRWTPEGRPYFVDHNTRTTTWVDPRRQQFIRMYGQNNTNGQIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPAMRILSGQCHIKVRRSHIFEDSFAEITRQSATDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGINPEHLNYFKFIGRVVGMAIFHRRFLDAFFIGALYKMILGKPVTLADMEGVDADYHRSLQWMLDNDISGGILEQTFSTEDERFGVVTTEDLIPGGRDIEVTNENKKEYVELMVKWRIEKRIAEQFQAFKEGFQELIPQDLINVFDERELELLIGGIAEIDVDDWKKHTDYRGYTESDEVIQNFWATVRSWDGEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGDLSNLPKAHTCFNRIDLPAYKTLETLQQKLTIAVEETMGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHU7</accession>
    <name>A0A2T4CHU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1466762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHU7"/>
    <dbReference type="STRING" id="983965.A0A2T4CHU7"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="111"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="290"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="499" mass="56395" checksum="4C6E170DE2525C11" modified="2018-07-18" version="1">MEPALRRAAHSLCGRCSASLRRQITAGGALKPLAQVPIRSVHSCKSADSKRTIAAPKVTTPAREYSSEASAAGKSAPSTLRLSQDDLFHPFSESPVPEFRRRAAFMRQHAYCPHPDHKHARAPIDASTVSDAAPATGGDMPPANVDFECPDCGIAVYCSKEHWMDDYENHLKICDTLRQINEDEHDLRSGRVFHEGNLPDLQMENAAVNMTNWDTFMYTREFEAIDSDRSMRQITRLLTYPITIGSVLHELSPYNIQKGGRLTVEGLKSFSALRYNLHIPRSGRGAGVNQLRPEPPPVRLFILGARAESSLPRPIWVQLAHLFPESRLHLIFIGPESMANRDDEFPLPERTPSNPFGTVVEDRVWYNMKISTIVDYYHTIHKTGHFAPYDPYFDCFVLFHPGLGHPASSHDWEETLPLLLETKVPIISTGYTEVDVKRDVEWVKKNSGGEFDMLLEPGENIFRSLRWDLDDMDPQDITCGNWGVWAFRGKRYETTTRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHX2</accession>
    <name>A0A2T4CHX2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1321741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHX2"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF31">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="258" mass="28638" checksum="8424D3016718863E" modified="2018-07-18" version="1">MEYCSTCTGSLASTPPYSQTPPSSSPSSLLPQDRRVECCCRVICGKCIQQNPRFASYCPFCQVSSTPSPLPQGLRDPPQYSSIPPLRSRTIPPSAPPPPYNSSASSSDIDEKAAQDDDTLHFLDHNHDTVQSLSLRYGVPPAALRRINNLTSDHLLVGRKTVLIPGEFYKGGVSLSPRPVEGEDEELRKGKIRRFMTACKVADYDFALLYMEQAGYDIDAAITAYLDDEAWELSHPNQRRRNGEATKVKNRGLFWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI57</accession>
    <name>A0A2T4CI57_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1011221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI57"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="16733" checksum="7752AE9BD35D8254" modified="2018-07-18" version="1">MSNSTLEFHQIKLAVLSNLGSSNPLPRSIPGYRPAHLRRRRHGGLSARAITSILPVLHNRLPWKQLVPPTAANRASVTMVIIVSGRISSALRAAASPSPSTTLMLWHRFIFSASPSPPRQVQHHRSAVSPRVLVLHCCVWLAVCMSANTVAGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIA3</accession>
    <name>A0A2T4CIA3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1012190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIA3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="12741" checksum="4FF792658E60900E" modified="2018-07-18" version="1">MGYCTRPPTIGQLLVICAILPRGQGSRKSLRRSGATVPSRSIFSAMSHWLYLRGYLRYLAGITWARSSASEGSHDSETELHCLKILRARDLAVLIDDCTARLRCMILHYDGKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIH3</accession>
    <name>A0A2T4CIH3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1346121</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIH3"/>
    <dbReference type="STRING" id="983965.A0A2T4CIH3"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="186"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="12">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB81369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="447" mass="50050" checksum="D2E285396248070A" modified="2018-07-18" version="1">MAFKPRSTRRRLVLLCASFLLTLSTTYLLLPHDSHIRLSINFNSSRFWNALRASATDRDAWLRQRPAPYPLSLRDDVGYLIKTGYGTRRRLPALIEAFARAGDILGDEHQSFIVVGDWTPPTNHTADGLPSVYNVVDTLMETKLDPSLQGHPRLSKYRSLREAIDSGDEDQANKLSQEFGWELDALKKKWYFILDDDTFLIGPSLHLLLSHLNPNRPQYIGNAVGDYKSRFAHGGSGVVLSQEAMRRLFSNPGIVAQSHVDSLDETWGDRLVGTTLIKLGIYLDERYSHYFNGEPPEMARVQGDRFCSPIVSLHGLRRPGAMEAVGQALSDRQQPVLWADLWQLFAASSLDNAGREPVRQMRDHVGPTGDDTTTWEGIASAEACRSKCQYSKSCLAWTFDRETRACRTSPSMVIGDGSGSETEESGLDVQRVESLVQHCGRASMYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIX0</accession>
    <name>A0A2T4CIX0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIX0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="17435" checksum="BB825B8A8C9C0E3E" modified="2018-07-18" version="1">MSHLIHPAQDTIQTGRRFANWRLGAAIRAFLPATSNGARPLDVAQRGMNRCLLFAMEKVMLVRWEASFQSALMMEGGVTGKVQPRRKHRHPRKKKLKWMTGRLTTAVTAAGGGGRRKKKGNKERERRKKQDPSPPMEKREEETRARASPINLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK11</accession>
    <name>A0A2T4CK11_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1298350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK11"/>
    <dbReference type="OrthoDB" id="4749603at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="64" mass="7625" checksum="6D37513DC2392BE9" modified="2018-07-18" version="1" fragment="single">AQEWRNNEPQCISGEYIVPQRLEAALRRNWDTQYAVEMRSNTYRIRAPGKLSEDEIRTFYSPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK15</accession>
    <name>A0A2T4CK15_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1435557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK15"/>
    <dbReference type="STRING" id="983965.A0A2T4CK15"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="4">
        <location>
            <begin position="98"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="315" mass="35666" checksum="B8F0CB7950A0F1CE" modified="2018-07-18" version="1">MPAPSSAQQKALLAQFVNLTGVTERQATRYLKSTGYKLDEAVDAWKGVKQHLPSKVAKGVPHWLSKKKRENDGADGSAKDQSGRYFMNTANEGKGPSALDTKLDALFDSLRDDENDEKDQLELESTMNYLGEKLNISLENAELFVVLELLQAPSVGEITREGYINGWKSSGVEASHQEHAKHVRNLVSNLSRDPALFKKVYRYAFVAGREKDQKALALDNALIYWSMLFSAPGLVWKGKHDWLELWKTFLGEKWTRSVNRDMWNMILEFALKSINDESLSFWSEDGAWPSVIDDFVQWCRQRGIGKSETMEVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP56</accession>
    <name>A0A2T4BP56_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1345067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679158">
        <property type="protein sequence ID" value="PTB71066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP56"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="6104" checksum="4423D7475592C2ED" modified="2018-07-18" version="1" fragment="single">VNYFKTFILIIILIIYKALFIIVAALDLKIKQIDIKIVFLYKNIKEDIYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPA9</accession>
    <name>A0A2T4BPA9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPA9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPA9"/>
    <dbReference type="OrthoDB" id="5689at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="180" mass="19993" checksum="E910DEA77A8BDA67" modified="2018-07-18" version="1">MAPISLSIRKATPADLLPILTLVRSAYRGETSLRGWTSEATLVDDQRIDETGLLAKINEPHGAVLVAYDDNERGEIIACCELLKQSDTLGYFGLFAVNPLRQAGGIGKFVLAAAEDYAKSTWGLRELEMSVIWTRAELIAWYVRRGYVVTEKRKPFPYADLVGGKALRDDLYFVVLIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPU5</accession>
    <name>A0A2T4BPU5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1406654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPU5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="20691" checksum="7DA005C78458601B" modified="2018-07-18" version="1">MSFAPAECATARNTVTSSSMCRISTACQRPSRLRPDLPLRSRIQTADLFGYLLVAFVTRCKVLSSCDKTQRTRKETDGQLLKTVVRADSESGIMIGARRWTCYVSPFFASPSPELPQQLCWDAPSHCTHLDRLPGGSGALYKCRVLGRPGMGVMVLMDSSPTIMRFRGISLTGVCKNTYVYIRTVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPW4</accession>
    <name>A0A2T4BPW4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPW4"/>
    <dbReference type="OrthoDB" id="3497702at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015741526" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="128" mass="14050" checksum="D6F247F86DF0992A" modified="2018-07-18" version="1">MRFSVASALSLLALTASAAPNPPHNPGTVQVQFANDQTGANGNARIPLDGRPVNLGQAYGHTNLEKDGTLFVTSLFFTADFQNVECIVLRDFHTKVADISNPTRDFQTFSQKPVDWQNRFTISCKKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQH2</accession>
    <name>A0A2T4BQH2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQH2"/>
    <dbReference type="STRING" id="983965.A0A2T4BQH2"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="374" mass="42771" checksum="2C8CAB1BB6845E45" modified="2018-07-18" version="1">MSFLFGRGRSRAAADLPRQARDHILKLESPNGVSKAEELARVLNQMKVVLQGTQETESSPEQIYQLVTALIDEDLLHLLATNLYRLPFESRKDTQVIFSYVFRFRPAAAAPKSDPIALSYVVCNRPQVLVELCRAYDHKESATPAGSVLRELIKNEAAAAIILYDDGDEPGSSCKGLNAIDRNRPQSGRGVFWKFFDWINKSSFEVAADAFTTFRELLTRHKDLIPKYLSTNFDLFFDKYNNTLIQSNSYVTKRQSIKLLGELLLDRSNYSVMTAYVDSGEHLKICMNLLRDDRKMVQYEGFHVFKVFVANPHKSIAVQKILLMNREKLLVFLAHFLEDRTDDEQFIDEREFLIKQIRNMPSTPVVSQRSVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQM1</accession>
    <name>A0A2T4BQM1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1442537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQM1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQM1"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="348" mass="37442" checksum="1456258AA3099C5D" modified="2018-07-18" version="1">MAQQTLLSPAELAYLHSSLSLSPPIRPDGRTAKQFRPLTAETGILPGTNGSARVCLADGTEAIVGVKAEIEKTADPLGDDGERYREGEWLEMTVEIPGLRDDDAGTVFLAELLREALLADGELAKKLWINRRFHWRLYLDILLISPPLSYPLPLLSLTTHLALLATRLPRLKSEGDEDPMFDDDWEAAPFLYPRQGAAAGSRPSITLLVVAVGDSILFDPSKEELAVADSALAVSLCEVRRERGRASMEVDSGRELRLVAMRTIDPPSRLTPPGVPSTANLAASGTADGPLQQKQQQQTSEEGPQEGVWKAPLGGTPFAVLDGIIQAVLEKGGVADEVLDGLEGVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRF3</accession>
    <name>A0A2T4BRF3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1343380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BRF3"/>
    <dbReference type="OrthoDB" id="4900038at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015523343" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1277"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1310"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1501" mass="167763" checksum="212BB5157F653022" modified="2018-07-18" version="1">MLPISILSGLLMLWLAERVSADGGDDFANNLASDLGPIIALFGERVVMQFMSQAMGIADCILLAVLPIGAITTVVSAIRVAGPTSLKSLIGRARENLSAAEVEVMSSTSEEVCELWNGHSVVRCPGSANIYQFICLLPKDFDPKSVSKTGITVRCEELSELKDEDGNDILEKKGQSKTRYFNSHMLNHILSRLNVRYQRLLSFHVSFSQKLDLEAGTIPDGSGFSTQMEVDRSGRTNVTHRTRCPPPIPGSKSEKTGSSESKPSGVKDPKSGEEKEIIVIMDTSDKSSPNLLLNCHDRVSRREIYIYAALGVIIQFGVLIYFGISSYYLPINHRFFLKVGKRIVGYAFPCAAAGTILLVLGLFICARVVEKSTTETYYKAPNHQMFVVWLQKDHTVSDQVFKPYAIYPAGERQYITMSRRNIGRTGQDEESGEHVAKDQQNKGAGNSLWDRRSKPMTFFGALIALIGFISQFIGMRGLNWTASVVQLIATLLVTAFRAIVRRGLSKSPIPIPLLSNTELDWFSLTFGDLASAPWALSKDELPSVREHVVSQDEKSPKWTVRTGGNQPYRPLREPSSDIDEARKESAAHKMMVTRQMLCKLSKWKSSVREEAVLLSRAIELAAETFLSKLPDGKLVWTIAANFREIDEDIFIGLEKKEGKWRVEEQNLEAALSLWLYSTSSARESNGEQPLNLRLYGPVQSRGRLSRDLVWWMPEEDGSEENGSEEDGSEGNRSEGKLRYVVVGFTSEVQDSTGKSLEMDTVHKPNEEYLVVECVDTRERLYCRDLLFSFLRAVAKMPEVTIESARSKSQMRYKDMTDGWEQLKLENTTISGLARKLEKIGFGALSDIYFDLTMPLSLERKLTNIKDVIDEANEQAQKYEQSHQWKNLVDTCCCLLDLAKQFDMEKEPSGPKAVAVCLEYFCRLRHEAELQRDEVRGEKELTMQLEVLKERLESINKDLGEFALFPRVKHFLAESGRGYATTFDMLIGATPDATTMFPESFNIVDKHRQLMRASGSGKTLYWWAEELGNVDIFGWSPLHYAANWQMGDVRFVIWDVGDVLSLRDLMGRTPLHHACLKGNKKAVDLLLAGSVPIEVAGNDGITPIHCAVLSGNSNILERLIEEVNSDRLKHSRESTSHVDRNRRLPIHWAAAQGRTDMVQLLKDDIDLKDRFGWACIHLAVIYKHKTLLEYLTKDLSADVNLRDNNSRTPLHLAMDIRSWEAFNVLIQAGAKLNVKDRDGLTPLHKARTALHLAIGSKRITEKLLKHGADTCINAKDMEGRTPLYLASIGGTAEVVALLIDKDADVAIAAEDGRTPLHMALSRGKDGLEVAKRLLNFVPGVEEPNPYVNAKAKDDATPLHSEVVRILLERGADTKPLNNLDFTALQYAVYLEDLDVVKEFVKHDMISAPTAPKAVMDRGENGDIPLHTLCRYSWTESAESGMCEMLEALLSVATDIDMINTLNAEGLTPLDLARFKMDESSTFIGKLKEKGAKPSDKEPSENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRW2</accession>
    <name>A0A2T4BRW2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1342583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRW2"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="374" mass="40676" checksum="B724967F299B2016" modified="2018-07-18" version="1">MGLGSVEDYGVVANPVNWSLTALSTFIVILRLVCRACFARGRYGRLGLDDAITLACLVILIASSVCSSIGIGYGLGRRERTLAAEQLKQAIKWNAIINAVVIWSFSLPKFAIIAILKRILNYGAKTMAAFLAMAVVSQGGILAVSVWWFVQCRPVAHQWDPEVEGTCASVGIMTKLAFATTAYSAFLDLFFAFYPIPFIMKLNMPLKNRLAVCFALGLSAMASIVSIYKLSVFTEAFNSMAEDRTYSVPYLDIFGVAEGALLIIGASLPTLGPLFRLLKGKVTSYASSNTRSGDRSQNNPSTLTSSSRRHKRGDGTSKNNHQINNNCVADYEDEEEGVSTTGLHSQSSIDDIPLVATAKPVARLREYPLKEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRZ8</accession>
    <name>A0A2T4BRZ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_166929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRZ8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="211" mass="22454" checksum="92E183C9EBBE6E30" modified="2018-07-18" version="1">MRRDGICVRRRAGAEADARAEVVMMQSGGGMFGRGRRCGGRNLLSWQQIDASGQSRRCHVFFFPALVLVLLGLGQGPLQGTAASPAFRCGAPLLLASPRCNASSTPPASPKIPVARGGLAGPNSERVLPVCLRVEFEPPHPCPVGSSVSARCCLVRGRLGMPEAKEPQYFRRLPATGASQAAGDGGRQRGQRWPSVEGQGGKQLRKDAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT10</accession>
    <name>A0A2T4BT10_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1465555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT10"/>
    <dbReference type="STRING" id="983965.A0A2T4BT10"/>
    <dbReference type="OrthoDB" id="5301473at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="115" mass="13575" checksum="B9F87FE6BA359994" modified="2018-07-18" version="1">MGSSRVFVHTLHIVRDVDAVVDPGWQADDAENQRSEERRFQVQEGLQRFAQRLHGEGHSYLLFLGSQDAQWWRTYLQHLGGEWWLHMPWTFTVHSRHARDVRLVAGRKTDGDVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTL3</accession>
    <name>A0A2T4BTL3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1472570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTL3"/>
    <dbReference type="STRING" id="983965.A0A2T4BTL3"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="362"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="642" mass="70963" checksum="CCA5618CB9492AAE" modified="2018-07-18" version="1">MAAAVSGLQGWHPGEIAIQTKLGYADAMATSWRYIENAMREQHRIFHTSNLPFIPITTLDDEGRPWASIVAGADGEIGFVEGPDLNALIVNARLWPGEPLLDTLNQWVDRYGQDPTSPERYLTAGIGIEFPTRRRNKFAGYMEDVQRKTTLDFRLKLKVNQTTGNCPKYINVRKLVGYPETKPTIAYEKRHMTQFERLPQEVIDFITDADTVFIGSVYRSEPETAAKFPSHTGMNARGGLPGFTRVSPSDGRTVVLPDYSGNRFMSSLGNVEKSKQVALTIVSFTTGDVLYLTGTAEHLVGPEALAVMVKHASVTVMKTTGFIFVRDALPVRQQFGTEVERSPYSPKVKYLVEEPEGQAGAIGAHKARLTCATQLSHDLAVFRFKVTTKPGVEPIRIRPGQAIALDFMDWIGPPAYQHMANSAPGSVNDDRVRTWTVSSAHEDKDVTWFDMTMREMKGGAVTGALFDVLRRHPVNEYERPITITEDVVVEVVGVTGDFFLGPDNVNMLWVAGGIGITPFLSMFSALSDRKAKAKGDVILALSTREPAMMLRLIQSCLRNAASKVQIRIDLFTSHEKVDMEGIGQESVQIILHRGRIGPDYWPQVASGRDVLICGPGPFGDVVMDGLRAAGVPEQNMLREGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU41</accession>
    <name>A0A2T4BU41_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1341182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU41"/>
    <dbReference type="OrthoDB" id="5130291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015532653" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="10541" checksum="1F0AA4F372FF663C" modified="2018-07-18" version="1">MFSYLAGLATLLAVATAQITTPCTYQEYVCGSTLIANGYTAAAELRAAYDLNPDAPTITDAQLGQVLFRCVDQAGGIVGNSYCIVNCAVIGDDTANDMCTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUD7</accession>
    <name>A0A2T4BUD7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1472760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUD7"/>
    <dbReference type="STRING" id="983965.A0A2T4BUD7"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="105835" checksum="4AA36AE1DDB3D28E" modified="2018-07-18" version="1">MATSITEAQAELINSLAPDDIPHKLRCANCSKLAVNALRLPCCEQAICETCHSNLPQSCPVCEHSPLSAADCNPNKSLRTTIRVFLRTAEKKREASRPKESNESAPPTPVDAPKPSLPDADVATPIEGPAEKAADAAEEGPAQETAPQSADEPAAGHEQEQQETAADNAEEALPPKEQSDLAETQGAEGPADEGDDATKGEEQDGAGEGDDGAGQAGNDQEQYGGDAANGGFQQNMMFPGGDFNQMQMMMAMQNGMGPNSFGGFPMMGEPPCRPLFSPVQTTDSPAGMPGMGMDPMQNMYMNGGFQGMGMNGMGGFGGGFGQGSNENWNGAQSWNFDQNNYNQNGPGMGTGDYGNFNSGFQTGYNQGNYGHFNDYRRNNYGRGRGRGRGFYGAYGRGGYHQHGGAMNHYQDQGQYPQYNQGQVAAAFQGQGEAGQQPTPTAAGAQVDEGANEGANEGASQTKASEGEAGADTDGPKQDDLDSASREAPGNDVFSGGPVRPSSAQPDGSSVQNRNGVAAIRSILSAPDAPINAPKGPKAMRQGLPNTSLLNLRARGFQIEDSGLPVQKSATMPSQPSQGPPSNPATQPGSRSSTPNVDRLRDRDPHRDRSRDHFRTWDKRDRGGEIEGSHGVQEKDRDRERVDRARDREAERSGSRASSRSRSLDRSSRSPSRSRGHRSSHRRQRRQRSESVGDEDKDDAYRRRKHRSSRRHYYDEDDELPSQRAKDDKGGDRSRSASPDDAKRSSHRSRKDKDKERDYERRKDKYRDEEDDHPKSGHRSSHRDRGDYEHSSRRHDKERERDKDSSSSRKDKDRKDRYRDRDRDRDRVRDRDRDRDRERDRDRGRDYSSRHGSGSRKHSADGNATPGGDKSFDPPTGPRGSRAAGSSSSAAQKDVHTLEREARNRERLLKEAQRMAGLAGLAGSKRSRDDADDGGRKGRRSRRSDAVDGDGEERLRRLEAEREGGRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUG3</accession>
    <name>A0A2T4BUG3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1086279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUG3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="105" mass="10898" checksum="7083E5DF110024DF" modified="2018-07-18" version="1">MSLVLRGGSSDVPALDLTAPGISFSGCRGTWRSPLGGARSLGRRTERGHAAKTDSFNQRPPSRHQPETSPAQATWAGPVGEPGGTCHDLPGSEISPVQHLVSSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV32</accession>
    <name>A0A2T4BV32_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1073406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BV32"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="201"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="729"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="771"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="813"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="854"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="895"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="936"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1265"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1365" mass="151779" checksum="E4422E1C9219A96E" modified="2018-07-18" version="1">MSKMIQSPIAATEANRRGIEYVIKRMDWYWKLASAILEDNANKSGISGGIRQELEAGVRQELETQVVDLYASLLSYEIKSVCSYYRNRGLALLRDIAGLDDWNGDMKNIQDAERAFYDDSNTYANLKIVSNLDRLVSHAETQSTVHLAKEDQQCIKDLRLTDPVDDKKRIEQTKGGLLQDSYRWILDNPEYQQWNNSGENRLLWIRGDPGKGKTMLLCGIINELNRQQSLSGLVSYFFFQATDQQLNNATAALRGLILMLVRQQPSLISHVRKRYDEAGEKLFEGANTWFALSDIFTTILQDPVLKGAYLVVDALDECVSDQQKLLDLIVRVSGTAARVKWIVSSRNLSAIEERLQLAKQKVKLSLELNAESIANAVKIYIGEKVHQLSDLKGFDENTHRRVRDYLLENANDTFLWVALVCQNLEKYRRWKVLDMLDAFPPGLDSLYKRIMGQVLEGDEGDVNLCKQILLVMMSVYRPINLQELGSLIEMNPEVSEDVGYLRDIVALCGSFLTIREDTVYFVHQSAKDYLSKNERAIFASGLEDVHQTMTSLSLQVMGRILRKNICALPWLGLLSDHGIHMSKTDPLSAIRYSCVHWVDHLCKGHAMEPYLEDNGLVYLFLREHLLHWFEALSLLHQISAGVLAISVLKDLIAAKSPEGELLSFLRDAHRFILYNRRGVELAPLQVYSSALLCSPTQSIVRKAFQRDFPTWIQNRPAVEDSWSPCLQTLEGHTDTVNSINFSADLMQIASGSDDDTIKTWDIITGACIQTLRGHTDAVRTVAFTADSRRIVSGSRDTSIRIWDLTNGACCRTLWGHTDSIRAIALLENDQIASASGDATIKIWDIKTGSCLQTLKGHTGPVGSVAPLAGGLVASGGWERTIKIWDVATGLCNQTLEGHTREVTSVTPLENGQLVSASWDKTIRLWDIATGTCGRIFKGHEEVVTSTAILANGQIASASWDHTIKIWDMATEVCIQTFEGHQAAFYSVVSLSNGQIASGSGDGNVKLWDTTMSASVESTRHHQDHIESIAFSSDGRQVASGTVDNKIKIWDADTGACIQTLVGHTEPVRSVSFLTNGQVVSGSDDTKVNLWDVDTGACVRTFKGHDGWVLSVAASADGQRIASGSADKTVRIWDTATGECTRTLDGHDTSVGAVAFSIDGRWLASGADDGRIMAYSEASGSYRKLGKHSRFIRSVAVSPDGLYAASGAFNSIKVWHIAARKCILKSHVGRGGYLPFDHLSFDPAMRYRIYSNFGYLDLHLKPLKDKSHDESQDESQDESDDESDDENEDEDELVQSSRPPSPTSPVTFRGFGLDWRVEWIVKDGKPLFWLPPEYRSYYSAAAGSTVALCVSETRVSIFKFSDAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW66</accession>
    <name>A0A2T4BW66_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1339666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW66"/>
    <dbReference type="STRING" id="983965.A0A2T4BW66"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="124"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="708" mass="80074" checksum="2A0A41661009FE41" modified="2018-07-18" version="1">MAHLAASKLPYRDINLRVTSDAYTFTSPSSPDAPSLVIDRPMGDIRLVQGGFNSTKRATRVSSIPGILGIIQLPLDKYVIIITKAKPMGRLKGQMVYKVLSTDILPMRERQIHDPDEDTFINLLKTFLAQAPLYFSYSIDLTNSIQRQSQADVSRPLWLRTDDRFFFNKHLQSELIKFRTAGSRSQPGSQPATDPYILPCIFGMLEIRQTTFKSTPLTLILISRRSRYRGGTRFFTRGVDENGHVANYNETEQIVILNDSSTGLGGFAGSSDMQSGKFGAAAAQEVQILSYVQTRGSVPTFWSEVNDLKYTPKIHVRSTDAALAASAKHFEEQIRIYGDNYLINLVNHKGRESKVKESYEQMTKALLSMPKERREADRLTDEKFTEIQPGSSRQQFDRLHYVYFDYHTETKGMQMHKAHAIVDRLRDAVDAQGYFRGVDMPGNDGRIEARSLQTSVMRTNCMDCLDRTNVVQSIFARHMLDRMLQDLGLLAKGSTFKDEDPAFEFLFRNIWADNADVVSSAYSGTGAMKTDVTRLGKRTPMGALQDGRIGVTRWCLNNFLDGPRQDAYDLFLGVYQPGEANVGTNLIFGDRRPVLIQAIPYILAFSVFIVLVGIFTRRPDNSSVIPMRLFILFWSSVAAWCFHFIWTHGMLYVNWPRLNPLPYAVDGFTESYSKARKDPVIGSLVARHERGVSTARFINAEEGKKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWB4</accession>
    <name>A0A2T4BWB4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_133553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWB4"/>
    <dbReference type="OrthoDB" id="5226533at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17110" checksum="966D8BE231C6BEE4" modified="2018-07-18" version="1">MSLDFARAALAERRPSFFLQLAPATSSSYPHPERRPSVTEGTVRPRRASISSPTGLRVLKLAPVYCGEHIGQNKDDFYDVQATPPSPAVAPSAFLSLAPTTSSSYPQMPTSSPDALPESRRSSSSSTTGFRVLKLGPVYWGQHADEHKDDFHDVPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWJ3</accession>
    <name>A0A2T4BWJ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1464514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWJ3"/>
    <dbReference type="STRING" id="983965.A0A2T4BWJ3"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="959"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1239" mass="137745" checksum="5150502E0024086C" modified="2018-07-18" version="1">MSAPPKPSGSSARGLEPGHAADARPRGPDTSGELDLLAGLWQVAPFARLPADAPPELSDYVQDVENPRRVYAIHRASRRHDFQQLVDKYIYQLRSGCGSPNCSTATCFSCRKRLAGKAPIRRYNPTSARTLAVYLASQDNPYSGLCPYLGSPREVPPATNSLIFSTRPSPSQHGTRKPSDTQTPSRRKPSLGCVAKAPPCATATTRSRSSSLDKQRLGSQPGESKEDDATSRPAQIPASQISVTEKAVQKDYRSFAVATFGTVAFKMLEWLTPQSIEAMTDKISELGGYRQSNNTAAAQPPAGPTDSQAATDSQDTSAHQPAPLPSTQPKRNKAPRPTRTSSQDLAEPPTPMKDVSSKPKRNSKTTLRSSPSKSNRRTMDPMAISAGNEEAKPTSRPPSLNGFYPDKLARAGKTSPAIITRGVPEIPSKPAFFENLSPPTPTTTTAEVEDVDSGSSDTETIDEKDTPSSTPPTTRKEHVDPQAKPRPVSPLPEADFSSAKLLLPQSLSTLNVDLVEFICDVFQEDQTYESHFFGPLESHASYPKPQNLSKKLVRRRSTSRAASASQWKAFNEQALFTVLSDPHSLVRSFSRDGKLYDSQTLFYCMLRMTRAAPTLVLHSLWMAAESLFTTPMSFQASQSRPARALPKSRKPLSDFEAGCVVSVCLHALVAVAPFVSDSKTLYDMSRIRSTGLALGGNSLSTRQPQAICLEYEDVFSNDVAIRLARRVFSAVSARRSLATLMRMDGKNKAGQMDILQPLLSQLDLVHSGPVRVLEFPTAERLLHETRVPTLLLDWARTVLYHEWDGHPEILCGGAFHGALSLISTMYQNRSRLLMGDIQFRADYFSERLDTMEMPVSWAESGSSRNKGHMLDYPYLFSPECLVTFFRSINFAKMSRMFEESSSLKTRMSAIVDPGSLVANPHHKIVLQDMLKVASSKYLILDIGRDNVLRDAFDQLWRRERRELLRPLKVHLGEQSGEEGFDSGGVQQEFFRVAIAEALDPKYGAFTVDERTRMAWFVPGSVVEEWKFELIGVIVSLAVYNGLTLPNLDWKMRITVPEETVGDHEAPLVTNENRDQYVSDYIRYLTDVSVRPQYEAFERGFHSCLDHKSLSLLSPQILQSLVEGVQEIDISELRRYTRYVGWDASHHTVRDFWSIVKRYDDRMKRKLLEFVTASDRIPVGGMRNLQFVVQRNGDGEDGGNRLPTAYTCYGTLLLPDYRDKEMLRQRLTMALENASGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWQ9</accession>
    <name>A0A2T4BWQ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1403973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWQ9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="19279" checksum="9D32779D70440F53" modified="2018-07-18" version="1">MLHDTRMSLASIGEHQSTCNYKPDDSVACTTHTHQYNGAGKWSDSFGPACSYEHVPGCSVAMTSMAVQDKGYGLDEPLRSTTMHKSAQKHPIKVSVRLLVPWFQSPEAPPPADVKGSTYSLYTPNSRQSSTMCRFPLAYSFPTDYLQGSEAGEDMPSWSRGLYDYMPTMSASSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWU8</accession>
    <name>A0A2T4BWU8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1440739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWU8"/>
    <dbReference type="STRING" id="983965.A0A2T4BWU8"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="489" mass="54611" checksum="AA3A45910C73971F" modified="2018-07-18" version="1">MESNAVSTESEQLVCESCSKSYQRRDLLMRHRRRCRGLAKGRTRRKACDACVRAKSKCCYTHPTCSRCIKRGTRCIYSAQPASQAWPCAEHVNEACGVQIQGLQSHSSAGSQSPIHDLPTWNFPLSPYPLDTLDFNTAELTNISPISHLESLIERSYIPPTTPGNPPSTSLGPSSNGGTRSPSSLPISSTPLILTRVLGDYASSMIKGSCFAPFLHLPKVKGIEPDLASFPFTSMAICSSTGMNLSTDKRFFRRAIEAARHGLIANFPSYECMQQWDAIHALLIYETLELKEGIGLESEGWKLAMPVKNLEISFLLKMTRSYIEPYVQIRSCDMDAFHDRKSSPCSPQTTTWGRWRTTETTRRTVFIVNMINFLNNYNPTTRSTSPYYEPLNDDLILSMPLPCSQTVWLAYEEESCTLAMKNQPLINHSTPEPNQSTILEALSREICLSTILRKYSKESIQAAIGPHVGVGDSDSLRRLIILCATEQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX38</accession>
    <name>A0A2T4BX38_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1381877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX38"/>
    <dbReference type="STRING" id="983965.A0A2T4BX38"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000043">
        <property type="entry name" value="Amidohydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="40"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="337" mass="38177" checksum="B6051EF465AA2192" modified="2018-07-18" version="1">MLGKVALEEAFALPRMQEKTRWWASLFAVNPEKHAHEMTDITNTRIAYMDKHGVGYTLLSYTAPGVQDIWDSKEAQAFAVEINDYIAGAIKDHPDRFGALATLSMHDPAEAAAELKRCVTQLGFKGALVNDTQRAGPDGDDMIFYDGPEWDVFWSAVTDLDVPFYLHPRNPTGTIHDKLWAKRKWLIGPPLSFAQGVSLHLLGMVTNGVFDRHPKLQVIIGHLGEHIPFDLWRINHWFEDVKKPLGLDCKKTIREYFAQNIWITTSGHFSTPTLEYCITELGGADRILFSIDYPFESFGDACDWYDGVTLKNEEDVRKIGKDNAKRLFKLGAFKDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXE2</accession>
    <name>A0A2T4BXE2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_365068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BXE2"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="87"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="558" mass="61974" checksum="DCF1C84E171470D4" modified="2018-07-18" version="1">MRAFGTFRWLNCHLFADVQKAASSGARNFQAAVVPLAAQSQLRPFSGSALRFNAAQEALKKAQNDAASLTADSVAANLSPEEVQRLSRVRNIGIAAHIDSGKTTVTERVLFYTGRIKAIHEVRGKDAVGAKMDSMELEREKGITIQSAATFCDWKKTVDGKEEEYHINLIDTPGHIDFTIEVERALRVLDGAVMILCAVSGVQSQTITVDRQMKRYDVPRISFVNKMDRMGANPWKAVEQINTKLKIPAAAIQIPIGTEDEFEGVVDIIEMKAMYFEGPRGTKVRVTDQVPANLQELAAEKRQFLIEKLADVDDEIAELYLEEQTPTNEQIKAAIRRATIARKFTPVMMGSALADKGIQPMLDAVCDYLPNPGQIENTALDKSKGEESVALVPYNSLPFVGLAFKLEENNYGQLTYIRVYQGTLSKGTYLYNSRTDKKVRIPRIMAFRKAFPEAGGQVLEPLMKTTITAPNEFQGNILMLMNKRNATIHDTEIGSEDFTLICDCSLNAMFGFSSQLRAATQGKGEFSMEFSHYAPAPPHLQKELVAKYQAELESKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY68</accession>
    <name>A0A2T4BY68_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY68"/>
    <dbReference type="STRING" id="983965.A0A2T4BY68"/>
    <dbReference type="OrthoDB" id="3440029at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="641" mass="73014" checksum="B5F29F9CB76C3C94" modified="2018-07-18" version="1">MTSPLSPGSYQLSSNLPAGRPSRLEPHQSSPPRSSSRQTGRRDSSRVHHPGPAMMPSHSSSMASHQGYDPAAHVSTSITPRHSPRILHSSPPEHPSRRNVNIFDVRNENITEAEAHKRLTSYIVIRIKRATDPYDLDGDETAPPPTWEKASHLIRRDVSQQDARRKVRKLDKETGSVADKKEDLPSAIQRQLERAWRNLEETEADARFVYTLAQVDWKLKGGREKKRGGRSKEKRRSRERHGSKTKREWASVAAYFRREPGRNADCVRILKAQLAERRQGERGVHDDHRLPLRSSGRVPLPRNVQDDTSRSQARHFDHEPRLQRRSSLSQHSNSVAHRPLNTSAAPIPIPPRSNISQAIEAQNRKIRSHAPRTERQAMASSYNSRSSITSFCSWSTESSGSNMTPSSSVEQSHSIPPPPQLHQPRRQYHGRSRVRSSYHEHRIGDEFVVLEVARPQRAHHTADRLIRIPPAAPDPISAVSEADMRRRPDQKVYHGGMSRSMGQGSTPRQPRGIEDPPKSVRDHLYRTERNPSGRNQDMDQLGDRLSRTSLAGSPRSRPGEARDPVNHHEYVDVPRRSRNSSDDDGFVIPRPARGARRRRDTQRYMAERRRRDQDAWDLGRTSPLLYGEGQRRVSSYAGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYH9</accession>
    <name>A0A2T4BYH9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1338286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYH9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYH9"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="394" mass="45133" checksum="253DA89D58FC76C7" modified="2018-07-18" version="1">MSSHRPNAFNSLRMGEVIREKVQDGITGETRDLQYTQCKIVGNGSFGVVFQTKLSPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVQLKAFYYSNGERKDEVYLNLVQEFVPETVYRASRFFNKMKTTMPTLEVKLYIYQLFRALAYIHSQGICHRDIKPQNLLLDPNSGVLKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRKADANAIDLISRLLEYTPTERQAAVDAMVHPFFDELRDPATKLPDSRHGTGQLRDLPNLFDFTHHELSIAPHLNHQLVPPHMRPVLAARGLDIDNFTPMAKQDMLAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYL9</accession>
    <name>A0A2T4BYL9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1393497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYL9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYL9"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="706" mass="80644" checksum="F89F07444EAD465B" modified="2018-07-18" version="1">MADGHPVRDIKNHLLFEIATEVAHRVGGIYSVLKSKAPVTTAEYGDRYTLIGPLNHQSAAVEVEEMEPTNKELAATMQTMKDRGIGMLYGRWLIEGAPRVLLIDTKTAYNYVNEWKSDLWSVASIPSPPDDEETNEAVVFGYLVAWFLGEFVCHEKEKAVIAHFHEWLAGVALPLTKKRRIDVTTIFTTHATLLGRYLCAGSVDFYNNLQYFDVDAEAGKRGIYHRYCIERAAAHSCDVFTTVSHITAFESEHLLKRKPDGVLPNGLNVTKFSAVHEFQNLHQQAKEKIHDFVRGHFYGHYDFEPENTLYFFTAGRYEFRNKGVDMFIESLARLNHRLKAANSKMTVVAFIIMPAQTTSLTVEALKGQAVIKSLKDTTNIIEQAIGRRIFERSLKWHEGDPMPDEKELISGQDRVLLRRRLFAMKRHGLPPIVTHNMLNDSEDPVLNQIRRVQLFNHPSDRVKVVFHPEFLNSANPVLPLDYDDFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSSDYGIYIVDRRMKGVEDSVNQLCSFMFDYCGKSRRQRINQRNRTERLSDLLDWKRMGMEYIKARQLALRRAYPNSFHGDEEEEELEDFIRGPEQKISRPFSVPGSPRDRTGMMTPGDFASLQEGREGLSTEDYVAWKLPEEEDPEEYPFSLTLRTKQPGPVSPETQATLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYM8</accession>
    <name>A0A2T4BYM8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_116784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="248"/>
            <end position="309"/>
        </location>
    </feature>
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            <begin position="250"/>
            <end position="310"/>
        </location>
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        </location>
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            <end position="163"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZD8</accession>
    <name>A0A2T4BZD8_TRILO</name>
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            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
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    </gene>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
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    <sequence length="152" mass="17505" checksum="ED0613602B20228E" modified="2018-07-18" version="1">MAAETPDVPPSRLAVPSRNPLPLSASQESQVRDIYYARVRKHCADEIKAFANCALGRTFSVTFACRAEHTAMNACMKRHATQEEQDAAREEWFALRMERQRQRERKAKMAAAQEEFMREWWGLPEEVRLSRGREMAKRGEKIPPMRPEGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZQ2</accession>
    <name>A0A2T4BZQ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="180"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="401" mass="45988" checksum="B6EB3CCAFC8C1C3E" modified="2018-07-18" version="1">MRVGAPWSGLPCEIRHSILMVIVRDRYPGWASLASVCTEWQSVIETENLRKITLDEDSLKELKKNITNERRDRVQHIYLNVGLLTYDCNFCREEEDMIEMGVNTGLVIGPLFKLLKVLSSWPSRSPGKGLKLELNAYSDSDCMHWRNVARSGRHQLRGTPFVPSLHPAFDMVLDIDTPETTVRKLVIFENTSDELSVALHEIPGYDNFQEQVMPIITGAFAWASTAYEEIWVSLLFDARIFFCYCLEDYTWWNLRSLCLTSLVLHSEFPADAAALLHKAATVAMRMPKLHTLVLWNGEQQGHACAFIYRNSSLGPSITWRGTWDIDLYLTAVIVDAWKAVVSQTGWEDLSVCFERVQEEICCLGDAIYYLRLPCQVIEPQSLWEMRREERMIVPSSLIEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZR5</accession>
    <name>A0A2T4BZR5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1336599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZR5"/>
    <dbReference type="STRING" id="983965.A0A2T4BZR5"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="227" mass="25687" checksum="91A56CA85882017E" modified="2018-07-18" version="1">MPPLLPNPAVRGLSIRCFTTTSPASALRDTSSNRPSSSSSLLSINNSPSSSPSPRSSYNNYNNKWRSNQQNQQGNPGDAASTLLTRLKRDGSTTLRSKQAQIEQLRNQKNSADYLRQMPRRWEAGDVYSPHDMSPVEMQKWRKRSPRKADVVDALGIRPLDMYKNFSLIQEFTSTSGQITHSSGTSLRPVNQRKIAKMIRRVQGMGLYPTIHAHPEMIRDNFFPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZX7</accession>
    <name>A0A2T4BZX7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1403295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZX7"/>
    <dbReference type="STRING" id="983965.A0A2T4BZX7"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="55"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="570" mass="62266" checksum="41204406FB54F0D3" modified="2018-07-18" version="1">MSDRDDGLYAHQASPAYGQDPEKSSTRAGNYEHVHIHGLETSPETSLHRGLKARHISMIAIGGALGTGLIIGTGKALAQAGPGSLLISYLAMGFLVAIVMASLGEMAAYLPLAGFSSYAARYCSDSLAFATGYTYLGKYLVTTPNQLTAASLIIQYWCPREKVNPGVWIAIFLVIILLVNGIGIEKFGEIEFWLSSVKVLVMLGLILFALVIACGGGPNGDAPGFRYWHNPGAFAEVYRGGALGKFLGFWSVMVNATFSFLGTELVGVTASEAQNPRATIPKAIKLTFVRIFVFYIISVFLLGMIIPYNDSSLAFANKQSTGASASPFVVAASLASVKVLPHIINGCILIFVLSASNTDLYIGSRTLYSISSDGNAPALFKRTNKRGVPYASLLFCAAVACLAFLNVSTGSTVVFGYLVNLVTIFGILTWVSILVTYLFFLRARRAQNIPDSSMPYVSFAGKWGTIIALFFTVLVTLTKNYDVFIHTSERQFDYKNFITGYLGIPLYFSFFFGHKLLTGSRIVKPHEVDFLTGKDIIDTQEREYLEEQEAKHVNSTGMRKFYDRFVSWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZY0</accession>
    <name>A0A2T4BZY0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1036829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BZY0"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000176">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1300"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1253"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1300"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1342"/>
            <end position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1354" mass="149194" checksum="DF2C2A315C2133A9" modified="2018-07-18" version="1">MIESEIDLLKNLFHDNIVKYIGAVKTTECLNIILEYCENGSLHSICREYGKFPENLVGVYMTQVLQGLQYLHDQGVIHRDIKGANILTTKDGTVKLADFGVSTSTLAGGQDKEAQVVGTPYWMAPEIIQLSGASSASDIWSVGCTVIELLQGRPPYHNLAAMPALFAIVNDDHPPLPEGISAAARDFLMQCFQKDPNLRVSARKLLRHAWIVGCRRTDAPVSRPPANFNEAVEEVKQWNKALNSSGTSLRTSTGAEGISRYPTGTPSKSRLSLAKPRLSAGAPGAGAFKLAELDDDNWDDDFATAISPSALQLPHLRPQDNFGGLLSADKLKAFASVNDLRADVNNYDGDFEGDMMTIKGPNQQEQQSHQLYQESQEQTIRPVSRRMTASKPASPPKVLHQASRSAPEPAVTSPHLSRTKSPPKSHFGNKFELPPRPGSIYREQSSEDYSDLFSDDDSVFDQKVHQAVRKGGLRQPEAPQLFHPSDLTSLPRSMQAPDGSVVRKKPLSRPSVLPDRPMRRTRSSIEIQKFAEDDDEDFSDVFGPEESIAEKEESERGSEDAGLMLMSRMSGNSWLGDDDDEDDPFASMDPGWDEMDMDAKIARDRHARLAEKVEELVGSLKMTEGDDILAELSEDLLVLLWENPEAKNLIISAHGLLPLLEILEPCTVKSRHHMILQLLKVVNAIILDDVEIQENLCFVGGIPIITKFAARQYPNEIRLEAAAFVRQMYQTSTLTLQMFVSAGGLNVLVEFLDEDYDNSRDLVLIGVNGIWNVFELQGPTPKNDFCRIFSRSKILYPLALVLHRVLDEEGEDELSELIEGRIVNIFYLFSQAENYVKEVVADRQVLKSVLKDLRRMTPVHQITMLRFIKNLSMLSTTIESLHSADAIDFLIDLLSYSMKKNHKHLREISNQVLNTMFNLCRLSKERQEDAAVGGIIPLLLRIMKTDRPPKEFALPILCDMAHSGSKGRRYLWQNKGLDFYVSLLSDQYWQVTALDAILVWLQEETANVENHLMDNGFSRAIVSCFGTNRLNAFDFNLLEPLLKLLRLSPGLTISLAKPEMFAGITQRLGHKKAVVRLNLLRLVRAIMDVCEPGALGSGDGARTLNSAQMRSLMDSIQVLADKDSAVLVRNLASELVKAHSSQPASPVMMRHDGMISSTHVNLTSSSRRGSRHNTNYTPQGLGSPLSMPQTPTHRSRGSMAGSSAYIEVAASPRRSGAALDRDNVMYRPQSRDGSATSIPRRISNDFNPMPGSSSGGGSSGSGGGIKSRMPRTPLTGGIQNRSSAGMLRSEFVAPMVVRSESNLGGSSSSRENGASRPSSSNSAGMAGVGVGVSTPKARHKTSSSSIDVMRQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C002</accession>
    <name>A0A2T4C002_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1423881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C002"/>
    <dbReference type="STRING" id="983965.A0A2T4C002"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="71" mass="7918" checksum="03EAEE35B8AA311E" modified="2018-07-18" version="1" fragment="single">KRLTAAQALQSVFFSTGDRVSANCFEGVKVEYPHRRVSQDDNDIRTSSLPGTKRSGLPDDTLLRPAKRIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C088</accession>
    <name>A0A2T4C088_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C088"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015557621" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="70" mass="7884" checksum="67DACD6EF7F92C02" modified="2018-07-18" version="1" fragment="single">KNPLVTSWGMFVYVYVGLSDGQPIQTAWNFGIGCLPVIIRVKGREYCSEARNWMCYGLHNIVETATRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0G7</accession>
    <name>A0A2T4C0G7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1431651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0G7"/>
    <dbReference type="STRING" id="983965.A0A2T4C0G7"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015693220" evidence="9">
        <location>
            <begin position="19"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="162"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="11">
        <location>
            <begin position="622"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="950" mass="102276" checksum="A6A189E41EE1B696" modified="2018-07-18" version="1">MKFSPTLGLLALVGGASSLTVTTSADQLRSKQNTTVVPNTFIVELQPDFHPELQPKDRFAKTKPGAKPNWRVRRQYNDTDIFYGVSVSFDSPIDLATLRKTAGVKNAWNVALVPRPELRGLWGSPSFNKGGTKLPDYRCSADVNRPLDMGNVKKLHDKGIKGKGVQVALIDSGIDYTHPALGGGFGRGHKVAVGYDFVGDAYDGSNDPVPDGDPLATCEDGGHGTHTAGIVAMQDPKKQGFGLVGVAPEATLAAYRVFGCEGSVTNDILVAAMVQAWRDGADIVSMSLGLWEAWEEINPFEDVVDKLTSHGVAVVASIGNFGTAGPYSSSTPAISLSALSVGSIESDVYPTAYTAHDDQHKAINYIHVFPATELGRVEVVQLGYGLNVPITPNVTSGCDQDAWDALSNAQLDWNTTILQVSWESWCGTAWGPAVDLGVKALLVTMTEAQNILVDEPGTEPPALYLDVDNSKLLLSRLAKQPAGKKYALTFDGTKAVDVANPYGSAPDYFSSFGPTIEMTLEPKISAPGGTILSTFPVDAGGYAVLSGTSMSAPFVSGSLALLKSQNPRLTVPQLYARLMTTARPANELNSKLTASAARQGAGMIDAYAAVEADTVISPAELNLRDSASPAPQKITISNQSRSRKRYSLQHVPGTFYRLSNNYLSDIEDNFSSANLPLTLDIPASAQFSQSSVTVGPGQSATIEVQIKPQTDLYPFANPVYSGFIKITADGDEYSVPYLGVPYNRTEVGPIVHNVTTVKPYDSPGLLKAQATNLFLPDALTPTPNLETYNWTTDLDKAYIPIFRIDTIMTRFLRLDLVPANVSFVPSMYGFDPDVHIDYKFPDQPILPGFLDVPTYGFAVAESLEPQPEGSPIVQSTDIGHFLGLALLDPSLTDDKGDKFRIAAGDYRALFRALRWRGNETNPDDYKSWLGPVMRFDIPSDLPPDFPNGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0X2</accession>
    <name>A0A2T4C0X2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0X2"/>
    <dbReference type="OrthoDB" id="5227693at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="225" mass="25215" checksum="B28EA519EBAB616D" modified="2018-07-18" version="1">MASYHRVLRTFGRTIEDSILECNYDIHPWDILINNERWAGKIRLVGYIDVFFLMCYSGDSRFEHGIIIYKDDEAIRQLLKKAGLKPEDKSIQLECINKEDKEALRKYYSLNTESVGNKHTIVSLGHPIGLSSKCPKSKLKKYTIVLHKGHTPAMQKEILRGVMQHGVVRLLSDALKLGIVSTAEIINKIKETVISGSSLDAVTTKSKNALTSSNSRSNTSPGNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1C2</accession>
    <name>A0A2T4C1C2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1423421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1C2"/>
    <dbReference type="STRING" id="983965.A0A2T4C1C2"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="257"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="425" mass="47315" checksum="23D45083B44CC6BC" modified="2018-07-18" version="1">MALVNVRRDVSDAFYRYKMERIQTKIEGKGNGIKTVVVNLPSVAQSLARPGSYVIKYFGFELGAQTNIDPKDDRWIINGAHDAAKLQDHLDGFINKFVLCKKCKNPETDVVIKDDHIVLDCKACGQRTDVDLRLKLSGFILKNQPKKGKKDKAERRAAKKAKQNGQAVKENGQGSGEDGSENGSNDAAENGDVSDDEFQKMQAEAITAASKNDIEVKEDEWAVDMSAEAVKARQAQLPDELKQKLNIGGDDEDEDGEGGGNTVYDEFGNWINQQAEEKGGIDNVDSINIYLKAKELGIESKHRSVLVLVQTIFDKNIVAQIPKRASMLKQFVTSEKHEKALLGGTERLIGSLGKENPEMFQQVVKVLQLYYHHDLVSEEVVIPWGSKASKKYVDVSTSRKVRKAAEPFINWLKEADEEESSEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1F9</accession>
    <name>A0A2T4C1F9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1431880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1F9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="68" mass="7786" checksum="8FF485D6DADF4899" modified="2018-07-18" version="1" fragment="single">SSPCYNCENALSRLLLWKAQVHRGIEALWRPLSQSSHGADAGQRRPHCERKVSERCHIHQTPSNVPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1X1</accession>
    <name>A0A2T4C1X1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1470540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1X1"/>
    <dbReference type="STRING" id="983965.A0A2T4C1X1"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="488" mass="54970" checksum="15BBAAAAF9DC110C" modified="2018-07-18" version="1">MTDSLSLVFITVTNRLAPDDKHARKQIRKQAMSRCANDRRKRGGYGQHNLIQYPFELPQDEDDRERDTARKTAGVSVKTAIPTTPASCPYERMRVRYNFDLLDLAQLTSFHISYATASRLASKPTMLTEVLGDRHWSYLNYLPSRLGHNSALDKAAACVAARAQQWLSCPSEPVSCGILKLYSSALKALQAELQCPEACLRPDVLCATALLGVYELFKMSTEDAWKHHSTGASALIKLRGPGRCESDFEKALLLSHIGQIFHEAINANQSCFLSEDAWQAALFSIPTDDSLFSDRSEPIVSLLANVCRVPEYFQKTLQIVCVTRDDTPECMVERVKNKLYQLRRSIMLWHETYFGSETADCASMRINKDRQHEALGFSYAVSIILNRLLFSLDPGSNASCEEAAEEYAFKILLIEKQGLSTVSQAELFMAIKLGVARTTLATAARWREWYMESTQSEFPTGSRLLPSAIFMDWCQRMGWKTPRPVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C232</accession>
    <name>A0A2T4C232_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1378150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C232"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="514" mass="57462" checksum="9CA253D51EBD2376" modified="2018-07-18" version="1">MAADTVDKTEKLDLEQTPTLGVAEKGEVIQLDADEALNAVAGLDTAALRLDEETERRLLRKIDWNLMPLMCLVYGLNYLDKTTLSYASIMGLKEDLKLKGDNYQWLSSIFYFGYLGWEFPTNRLLQRLPLAKYSAFNIIMWGVVLSLFAVTENFAGAVVIRLFLGIFEAAVTPGFALFVSQWYTKKEQGFRTGIWFSFNGFAQIFGGLVAYGFAHGASTYGFSIAPWKAIFVFTGVLTSTIGIVFLFIMPDNQLNARFLTKEERLLAIHRIKVNEQGIGNKHFKWYQVKEALTDPAIWGFVFYALVADIPNGGISNFFSQLIVSFGYTPQQSLLYGTPGGGVEVVALLLCGYLGDRLGSRILVCMSGLVVSMIGVIMIVAIPLDRPAGRLAGYYLTQASPTPFVALLSLISTNVAGWTKKTTVAAMYLVAYCVGNIIGPQTFRPEDAPEYRPAEITILVCWGACLIDLAFIWWYYRRQNHKKSLIRADPTYTKVENQEFLDMTDKENAEFQYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C309</accession>
    <name>A0A2T4C309_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1335041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C309"/>
    <dbReference type="STRING" id="983965.A0A2T4C309"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="24060" checksum="F42479341AC3D0FA" modified="2018-07-18" version="1">MAGMAGQPALKYYPDNIKAAPGSMVQFQFWAGNHTVTQSDFDHPCTPIHQVNSSIAGIWSSYMPVAAGASKKEIPVFTVMINDTKPIWIYCSQGKHCSAGMSMVINENTSANATRSLANYRTAAAGAQGGAPAAAPPATSPSSGSGSGSGSGSYPAPSSGSGSGSDSGSGSGSDSGSGSNAPAAPSAAPSAEPTNVLTPPPSVTDGAPSGTGVLPGGATDTGIPKSGASSVGVSTSLLLALGAAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C323</accession>
    <name>A0A2T4C323_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C323"/>
    <dbReference type="STRING" id="983965.A0A2T4C323"/>
    <dbReference type="OrthoDB" id="5392974at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52400" checksum="0B9039E3A653F4A7" modified="2018-07-18" version="1">MSWTKRSQEVLYRDFTEKAAAEPSVTAEKPWSLEVYDISQDGQLREYVQNTVRRLNGNPRLRIVFAPSDTPRRETKGLMVELFHKFGIPHDFTAERARSTNHSLSRRSSDDDGFSSWFRFSCISSLFEEEDESPSGKDNATAGAPLPDKYPLKETAFFLQASKGTNVTLVCFGAGLGVRRRFKDLIRSREWNDIDVHPEILFDIALEGLFEEVDDVAWRLEEEFAPLEQSINQSTDSEAMTSSFSQTLSDTYAFMRHTAELSRALESVLMINEGLIISTSASITSSCAPSSSDANRSRPSLVALQLKECLEYRRTLFRSTQLRLSALQKRTEAVIAVSSNLVLQQQSAAVIQGPVSMKLIAASILIFLPTITVATIAGSRLLLSEQRDEEGSWDVSATPLFYMLWYISIPLTLAVIVLSFCWLWWRQGRSKKKTVLPSPWYRKRIWRRATGNEKHQESNVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C360</accession>
    <name>A0A2T4C360_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1470832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB76006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C360"/>
    <dbReference type="STRING" id="983965.A0A2T4C360"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15767" checksum="3AF5671F64FA2DDF" modified="2018-07-18" version="1">MPPKKVAAPKENISLGPSARDGELVFGVARIFASFNDTFVHVTDLSGRETITRVTGGMKVKADRDESSPYAAMLAAQDVAARCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARAGMKIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C381</accession>
    <name>A0A2T4C381_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1402515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C381"/>
    <dbReference type="STRING" id="983965.A0A2T4C381"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="23185" checksum="5DA4CCF2645E35CC" modified="2018-07-18" version="1">MPTWRDEYLSSLRESELNNPVNMELVQACSQMADRISSLEAEKLALESQIASLGTSRTRSSPSLQPSQAAANDPGIAQLRLDLAEALRSRGVAEARLRAAEEELDKLRSRTKQDARTIKDLTAERSLLATKVHDREYELKEKRKLVEHVQDEMIALNLQLSMAEKERDRVKRENNELIDRWMKRMAQEADAMNLANEPTSAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3A2</accession>
    <name>A0A2T4C3A2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_312822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3A2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="19726" checksum="C7BAB739EA515DC2" modified="2018-07-18" version="1">MPPYLKTPAASRLSHNCIPRNVPYGQLPSCLSWSKLVHAPTPRPCKAWRRDVHSLRTPPLLELVCLHASPASHTPSTDSWSVHARTLRASRQAWQATRLGASPLAQPWRALNLICLGRWAARPHTPLPFFVMHLCELDCTRTGISTSSAMALCSYKSAIWSLLEPSSISRTSDHSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Z7</accession>
    <name>A0A2T4C3Z7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1306468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Z7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3Z7"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="328" mass="36270" checksum="AE9FDA3FE777AD39" modified="2018-07-18" version="1" fragment="single">MKRAPAGKKGVALSKRSQAAADAFDRLPENPTIEEIKEATVNVSLAELEERVADVRDSWETDSLLEDAIEELTDESGVYSGRPDTCTPEEACRLRRELREQGPAVFCQRTIDAGRYSAKKLLSAFGIRPPAFLEGQPDEAYFSLLRVAKAKKSRGRLADSSDDNSEYDVPSAGVMKPDITFFGEELPDEFSRRLTENDRDKVDLVIVIGTSLKVTPVSEIASFLPPHIPQIYISRQSVTHINFDIDLLGDCDVVVAELCRQLKWPLVHEMVPADQEITVKTEPGYPNRHVFTTNKPYVLENGDGAKVIEDAAKPVQNGKDGKQAKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C403</accession>
    <name>A0A2T4C403_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1391828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C403"/>
    <dbReference type="STRING" id="983965.A0A2T4C403"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="156"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="362" mass="41032" checksum="BAD934CE2FAF703E" modified="2018-07-18" version="1">MTRKWGNSLTVPAYLEREEYLLSIPLARNGGITNWILTDTSSAPVSDKDGEERPVLAACETLRKRALVRDPSSSDGAPRDVWAYGVASVFTNKAFRGRGYAGKMMELLRGYMAGQHRETGEPAFSVLFSDIGKTFYAKHGWIPLENTQIEYRVRENPPEVDTASNVMLLGEERIAELAERDEELLRKEMAKPNSEDPAKIRVAVIPDLDALQWHFYREAFICNASFGRKPSVHGALYTSPSTGSRVWAWFERNHYGGPEKPEKNLLSFLRFVIEDENIPDEELSEAVVGIFRAAEKEAKDWKCSKVEIWNPNARVRKAAEAAAEFQTTFVVREDKNLASLNWFGEGSAEDLDWVANERFEWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4S4</accession>
    <name>A0A2T4C4S4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1422626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4S4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4S4"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="486" mass="53403" checksum="B090276A1584E1CE" modified="2018-07-18" version="1">MTSKDGYSWTEAQGLRAGVPSIGVIEPPTNVQSDDTAYDVVVVGAGYCGLTAARDASLAGLKVLLLEARDRIGGRSWSSNIEGYPYEMGGTWVFWGQANVWREIARYGMQDELEISYDFSKGINKYLLSSPQGVQTFTHEEEDALMQSSLAKLVNVDGCLGRTVVPFPHSGVLTPEARKYDHMSVADRLAEIKNDLTPNERLCAEAFVLLCSGGTLETTSFYEFLHWWALSGYSYEGCIDYLVKYKFRGGQSSFAIRFFREALASGNLTYAFNSPVAKIQHGGESVQITTRAGKMYKAAKMICAIPLNVLNDVAFNPPLAPGRKAAATTGHVNQCVKVHAEISDKDLRSFTGISYPHNGLVYGFGDGTTPAGNTHVVAFGGQHNHFHPEENLEYTKAALQGFAPMNIQRLVFHNWSKDEFAKGAWFFPAPGLLATHLKDMRARERNIVFACSDWALGWRSFIDGAIEEGTRAAITVRGDFAGRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Y6</accession>
    <name>A0A2T4C4Y6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1421702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C4Y6"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000003">
        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1372" mass="152015" checksum="BA2D634C553BAF9F" modified="2018-07-18" version="1">MDLSSATAAANRAERFEDEKRRIIDSCFSKKDTDGLLHETYITHIRVTEFSSHSSMPPPPEARGLNTEKPRIIVVAVRKSGRVRVHKAKENSSGTFSIGKTWNLDDLSHIESYTGPKVSPNLREWAGDTGFLVTLGKPYFWQAQTEKEKKFFIASLVKIFGKYTGGKLPELSGFDQRELDQILGAGKRPTGTPPRQQMIDSTTSQQAIATSSAAPKPGPGEGPRYPRPSPLVRPSPNETMSPSGSFDSTASRERSVPRWTTQNNKSQDSIANSSATKGDDTSSLPPRSRSGMSGPSGLSGLSEARDASDPAPDSVPPLSRPLQEDKVPPARRRPPMDPSRPLDRDLVPAPLMSSTAKREQVMPPPRSIDRVASPAIPSVLQPGIAFASRTSLDEKPPPPAEPSDDVDQRPGSITANSDSTKDPASTSIGGTSSPAQLGTNDAGTPEKSVNETAEETRPGLGPMIKSKISKGDVAGAFWKAASAANAFRPRPGGAGERLRQIQAKANEGPDGITSVVPAPPRPVSRDTNLSGVEAPKPVTADSATSEVKILVPESNKTTGSQALAKELNEAEKDTAIPKETSRRPAVVGQDARYLQRMGIDPIILDDRSEEFGKWLDFFGWVPGDQMHCLNMDEIGNDLERELNTVQAGGWLARFREEDERVNTIKRGIDLAMGECEELDNLLTLYSVELSTLSDDIAYIEAQGQGLQVQTANQKLLRKELESLLETCAITSDDLQALQQAPLDSYSGLEEVELALVTLFRAMMKIDPSLGGDDTGKSLDTTLDADHTLGLNSNYGKMRIVQEKREMYLHESRHFMTRLLDFMTGQFGEAYVETKRALDGALSKKVDPAHHSIGRDLLWKYSPLMLYARDVDLENWNRLLQVYQDKSSPVYKHEFQHVISVWRKNARKLTGDEAEVIFSSQSEKQQEGVATAARKLTVKRSQTLAKALRSPLADGGTRTHVEKGSADSRSLPYEVFSGVLEDLLPLVEMEQNFIIDFFHATTLEQTDFPEAVAACPPRDRRGGDLKRHRLMEPDRELARRVTRSMEAIFAFLEAELRRLMEWAIAQDPLQGVGVLATLERKLSEMGQSNQDFLNALLQKLHASLEGQFRKFVDEQIRAIEETKVKIKKRKGVISFIRIFPAFMAAVENMVAGLDQNLVLRRTVNREYDRILKTMFESLMVIAREHPAVGVASGTADPEDKEALNFHILLIENMNHFLEETETRGLEVIENWKAQANTEYHEHMALYLNTVMRRPLGRLLEQIENIEAQLQTGKSAMAIARQPSNNKAAFNKVLGSYDAKEVRKGIETLRKRVEKHFGDADDPTLSRGLVVRVLKECEEFYTSVESRIGRIITDVYGGEVIFEWPRAEVKAAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C500</accession>
    <name>A0A2T4C500_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_299491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C500"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="188" mass="21251" checksum="2F1E0CB32B5AEB9B" modified="2018-07-18" version="1">MCLRNNDAPYIDKASLLSLSVFTHLSLVVSRHTSFTSQIGHHQLDPPCNTPYARGPLLLTPFRLLRLTETEEKSVRTHTVTALSLGPLTARKRPPISIPVASPQDERQKRGFTFFSHQTNQRLSYPIQNFLFQTPPGPPLSLQTPTPKIFIVIHFGVPVLSLFGSFSPCPYARVIRLLILLFDRRYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5I9</accession>
    <name>A0A2T4C5I9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1376136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5I9"/>
    <dbReference type="STRING" id="983965.A0A2T4C5I9"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="261" mass="29886" checksum="ADEFACAF8FCBA725" modified="2018-07-18" version="1">MSNRNSDTVQADARRFLDERGSSAALAPNGLNPATIMEKAVKDRIVDSYFYKEQCFALNEADIVDRVVEHVSFIGGTHGASQKPSPFLCLAFKLLELAPSDAILHEYLSFGGEHFKYLRALACFYVRLTRQAKDVYLTLEPFLEDRRKLRRKARTGTTLTFVDEFVDDLLTKDRVCATSLWKMPKRETLEDLEILEPRVSPLGDLEDLLEEDEEEEKDRERENGDDRDEANGEREESGEVSDRGGMDVDRDEERRSRSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5L9</accession>
    <name>A0A2T4C5L9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Electron transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1355084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5L9"/>
    <dbReference type="STRING" id="983965.A0A2T4C5L9"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="32248" checksum="43947438C8D527BA" modified="2018-07-18" version="1">MSQSVAPSRALQSALRSLPAQQCRRCFASSAFQPKQLRPVVPRSPVQSRQPITQKRTKYKTIEQAKSRYSTGPFSWKAAVLFVITCGGLVWYFEHEKERMQRKRIAEATKGVGRPKVGGSFELTDQNGKPFTSEMMKGKHSLVYFGFTRCPDICPEELDKLARMLDIVDAKLPNNQLLPIFVTCDPARDDPAALKTYLAEFHPKLIGLTGTYEQIKDLCKKYRVYFSTPRDVKPGQDYLVDHSIYFYLMDPEGDFVEALGRQHSPEQAAQLIIDHIKDWKSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5X0</accession>
    <name>A0A2T4C5X0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1239474</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5X0"/>
    <dbReference type="STRING" id="983965.A0A2T4C5X0"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015433405" description="chitinase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="32"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB76961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="390" mass="40677" checksum="7431FABEA4ED9CDB" modified="2018-07-18" version="1">MLSRTLLAALGLTTIAAAAPSQTLKTRQAPGGQNAVYWGATNNENDNLSTYCTASSGIDIVILSFLDIYGATGNFPSGNMGNSCYVGTDGVPQLCDDLASSIATCQAAGIKVILSLGGAASSYSLQSQSQAVAIGQYLWNAYGNSGNTTVQRPFGNIFVNGFDFDIELNAGSQYYQYLISTLRSNFASDPKNTYYITGAPQCPIPEPNMGEIISTSQFDYLWVQFYNNNPVCSLGLPGDAPFNFNDWVSFISSTPSKNAKLFVGAPASTLGANGNAGGAKYYATPEQLAGIVNSVKSSPYFGGIMLWDAGYSDSNVNNGCNYAQEAKNILLTGTACGGGSSPPPSTTTTNAPPPASSTPSNPGSGSVPQWGQVSLSRSSGSFEVKMKANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C671</accession>
    <name>A0A2T4C671_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1430734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C671"/>
    <dbReference type="STRING" id="983965.A0A2T4C671"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015678768" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="27889" checksum="B86D388988666D2D" modified="2018-07-18" version="1">MKPLVFISTFVQLLVPCSAVIKQCYYPDGSPSSDFPCNPNAKESACCGSGLGSTCLNNRLCQSNNGNIIRGSCSDKDWSSPECAPFCLSADNGGTDLISCSNVTNADNSFCCDHTNGCCDSGAGRFNVLPKEAEVWATWNVEASSYRVVGTVYTGNPTSTSSAPTRSSTSTGTTTATSATPTGTAPNDSDKSSGLSNGAKIGIGVGVGVGVVLLAAIAFLAWKLRQRKGYGAAPAQAPMQELDGRAHTPAELDARGKKNQDLRPPAELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6K0</accession>
    <name>A0A2T4C6K0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1206367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <sequence length="520" mass="58362" checksum="FD72AEC422420123" modified="2018-07-18" version="1">MFGSFGLANLPAKVKVAPEDIPPPTTICLPRYQPFVQDDAPVDPENALSNLLKCTGRTSATAGAIGLSAIGFDLKLDVEVDELIPDPTVLPDFQKWDKLTLEEARGLKQAERRFLSSGKEHPGCLVYVERRRELSHNNEEAFRTVRRLAPPKGMQQPRLGNAYEFFRCLEFFTMYWEDPTRPPSLPPSPELASTENGDAATAKESSPPQTTRTSDGSSMPPEYRQHLMTAFIKLVAYDFGCNVSMSRFEPRLHLSSPEGHPRPRKSYSPSNCQFIFQSPMTREAARNGLVYGPVGAVSTRPIIDFTTPDIETAQALDLAREVVAALITAQHRAREGKTETRFGENQWWTTKPRWGGGPGGPIGREVEMDTPSGSKDGAPADSERAARPAAKKARKNMSAYDAYRMVRPPAYTWDKKARYQAIGRQKGADYDDIFVISSVLHHVSILRVRVPDRLLEVLAGSPDPDVTRRSWGRVQGWRSRWFDFFNAEQRLEAMKTLWAVMEYQMRKQPTGEEDVEMADK</sequence>
</entry>
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                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
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                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 18648</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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            <position position="1"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="EMBL" id="PTB77312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="12654" checksum="07726579AB8DE3CB" modified="2018-07-18" version="1" fragment="single">EAQPNSASTDLADDARLGSNCLDADWLTDRGVAIGQSAPRHFQACGHSLEYGPLPSDYRRGTGLMSQIVRFPWLIDQSMDSHLICLLLQSCFAVLGLVEYWWRVRSENRRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C793</accession>
    <name>A0A2T4C793_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
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        <name evidence="6" type="ORF">M440DRAFT_1400350</name>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
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    </dbReference>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
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    </dbReference>
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        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
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        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
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    </dbReference>
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        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
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        <location>
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            <end position="43"/>
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            <begin position="684"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="107640" checksum="F3FE4F18C10E82E2" modified="2018-07-18" version="1">MASRYKDKDGGVVLSFNGQWVSWAHTAVAYTAFLSALIVGVSLHYHKIVQNEFYGYPDEWFPSVSATIGDRYPERSFFMIFIAITSGPRFALVGLWYILTRRSGSKLPGFIASMGLLRTLTCGGWTYITSTDDHDWHDILMISYIVCTLPWTTGCIALSPPNPSAIKWRKRLAGLFFGTLVPLIYFFIQHKVHRVAGAYTTYAFFEWSLILFDVAFDAVTALDFDTFEILVKDVKGTSKGENYSSVPSAVLEKEKEQITGGFFSIRFTSAEALDTAASIYHGFVFWSMLTSLGLVVWYFPLWHMGISGFEAFVMVTVAPSLLGIGVFRSFVMNNLRLIHVLSLSGVAAYLVVDPVLRLCAVGLGVGLSCLGWASSLHADSVHNVRLETKLLGWMIGLILSSTLKFAWTTNNPIWPIMHAANGGWNGTGLVLGILAALRFTRKGPLTGGSLTDEPKQQGSSVLAALGVGGLFFGLHSLLSDTSTMILWVWEGYPIRGPYFSTHGWFTVAAMSVGIFLGINRPGLAGSWPQYAVGAISATILTFYSHWFGYYGGLGLAVYLMAVSVPLISNAAKKEPAVTFGLGFLFYNFLVLFHVWVVAYAFVPGGPLVREHTDWVMLTTMLMIGAGVYDFQVSQGRHYTARRSSPSQHKKYFGLSTIIINVLFMCAAFRRFPTNDYKPYHPEDRILTAGIWTIHFSLDNDMWSSEYRMRDLIKEMEVDVIGLLESDLQRIIMGNRDTTQFLAEDLGMYVDYGPGPNKHTWGAALLSKFPIVESKHHLLPSPVGELAPAIHATLDVYGQLVDVFVFHSGQEEDPEDRRLQSEYLAKLMGSTDRPAFLLSYLVTEPLEGNYNTYVSETSGMHDVDPTDWDRWCEYILFKNIKRVGYARVSRSTITDTELQTAKFVIPSSEAEIKALEAQSPEERDRRVEEEDVPEGWRYPAMFRGEGVRDHRYHVFDEPRYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Q7</accession>
    <name>A0A2T4C7Q7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_3763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Q7"/>
    <dbReference type="STRING" id="983965.A0A2T4C7Q7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="182" mass="18870" checksum="8B8C77D5DDBCFEA4" modified="2018-07-18" version="1" fragment="single">MGSDSRPVCHRCAQIKQACDGSVPCARCLRLSLPCRPRDSGGAAGQQAGDLPKARIRRVQTGCLMCKRRKKKCDETKPRCGDCRRLCLDCTWPPERSKDKLAAAASVFASPAAAAAATTTATATATAVTATVAVPGSVVPMPVPVPAPVPIPAAAAVMTASMPVESVVAGRVIHEIPIQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C840</accession>
    <name>A0A2T4C840_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1400627</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C840"/>
    <dbReference type="STRING" id="983965.A0A2T4C840"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="6"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB77682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="397" mass="44261" checksum="7589E852A95BA504" modified="2018-07-18" version="1">MSSDGYRSVAYFVNWAIYARKHRPQDLPVEKLTHVLYAFANVRQDTGEVHMTDGWADTDIHWEGDSWNDTGNNMYGCLKQLNLLKKRNRNLKVLLSIGGWTYSGNFKGPASTPQGRETFAKSSVELLKNLGFDGLDIDWEYPQNADEAKNFVELLATVRKELDAYAATLPSYSHFELTVACPAGPTHFEKLDVAGMDQYLDFWNLMAYDYAGSWDQTSGHQANLHPSSDNPASTPFSTDAAIDYYTKSGVAPSKIVLGMPIYGRAFENTDGPGKPYSGIGEGSWENGIFDYKVLPLPGSQEFWDEAIGASYSYNPQTRKLVSYDTPYAARAKARYVKEWGLGGGMWWESSADKEGHESLIGTVVNEFGGPGALQKKDNCVDYPQSKYDNLRNGFPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8E0</accession>
    <name>A0A2T4C8E0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1438257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="VerF-like"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="931" mass="103624" checksum="3E41DF360C28BEE5" modified="2018-07-18" version="1">MLPLQAMDGPVALPPPNQPTALAIAEVGENRNQKPKTLPCKYCSKRFRRVEHVQRHERTHTKEKPFSCGWDRCGKTFGRRDLLVRHEKLVHLNEGHKDPSRPRKLSGTSLHKPSLSDSHVDLDAMGIHRLRPPPPPPPTTTTLLPPQPSPPQQQQQQQHPQAPPPPYHHGSMSSDGGSHLSQQTPQVAARTAACNLDLLSDAALASEVNTMQPLLNDIPQQPPTHSRVKSYPDTIEGYGDRARADPPILAAGFGPQPQQPTYEDYNLFLDDYTTPQHFLPPHFEPDQQMNFFARSPAVFQRGNSKPNSQLPSRFGSLAPDAQEPSSRLHEEPSRSPLRISVVDHGIIKNRLEEFSAVLPADFVFPSRYTLTRFLEGYISGFHEQLPFLHLPTLSPTELAPELLLAILAVGAQYRFESKRGYALWYAAKSVAMEQIRRRHSSEIHALLPNASSYSPHSTRPSPSTSYRHSFASAQSERPVTQDTHREPYSPNTPQSRLETIQAVLLLFSVGLWGAKTILNEALSLQSTLAILIREEGLTEDISQASVTDWDAWIKREGATRTKLIAYSFFNLCSIAYDLPPLLVTSELKLSLPLPARLWRAETAWQWQELRQSTPMVEITVHEAIARLFGRTNQGLPSHLSSLGFYVLIHVLIQHVYFLKQTSLAAGLPFEAQRTLKPEDVEEVTQALRVWHTTVEQHHYLLATGSGPFASTDFSPGGLLAYNATALLRLAYIRLYSDTPPSKELQTRDSMLMASAMISTPLLVRSVRLHGAVFQAVHALSMLVKAGVNYVARTKSTEWSIQHSLCNFECALLLAKWLLTLGSLTPSDAPITLDERNLLETVRRMLDETEFAVPVDPSLAGANANPQLEAATTDPMKLRQLASAVVRLWGETFKGTHIFDMIKTMGASLDGYADLVDKPRDRVALAPNAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8E5</accession>
    <name>A0A2T4C8E5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_18847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rpn7_N"/>
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        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="54"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="278" mass="31060" checksum="1673B8B9DF7F06F7" modified="2018-07-18" version="1">MGADPQYVKWPLLPLSQHVFTLTNAYASKQAQQAAAKALQDAIAQDKMAPFYRYLAHPIDGILNAVGESGSSAPGKPPSRKSSLVGMVATKAATGAINLPWDEDLYNKLKVDNDAELAAFQKEEEEAEEKAGDTEVMAAKGKRADFWARVGDKSLASVEEQFLNHDRYLHEHKSWFIREMRLRAYQQLLQSYRVVGLESMANDFGVTVDFLDRDLARFIAAGRIPCTIDRVTGKGVIETNRPDDKNKQYQDVVRQGDQLITKLQKYGQAVRLRGSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8X4</accession>
    <name>A0A2T4C8X4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1391170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8X4"/>
    <dbReference type="STRING" id="983965.A0A2T4C8X4"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="331" mass="37374" checksum="D032724078A22DAA" modified="2018-07-18" version="1">MASSKPPNGADGLPAYGAKEDAKDETAVLDFDRPRQARVQTPEPEEQQNGGLTPNGPGILGPFDWDDFEARYEKALVEADEQEREILKEAESLAKYFQVWSSAASAYDDERAVKRLQTRQRFVNIAEEKMAQRQQHRRLLMIPAILEAYLHQPFSSLQKRVTMSAVDELPFDIPQITSDELLAFQQSHFSNEAAAEFGHTFTSLPPQATSEHQPCEDWWEEEEDDGLGYYEDGVKRTLTDAQIAIFRHSEIRELRRQQEKQAGSKAPELPQDVSAKDMGTASPQDGGGTVGSQSKKRKRKKPKAVKQEPKPDLRKRTWDVVEAGLDSLDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C953</accession>
    <name>A0A2T4C953_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbohydrate-binding module family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1329206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C953"/>
    <dbReference type="STRING" id="983965.A0A2T4C953"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000534">
        <property type="entry name" value="Xyloglucanase Xgh74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015536065" evidence="9">
        <location>
            <begin position="20"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="804"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="749"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="842" mass="87632" checksum="568EF072EEF16F2D" modified="2018-07-18" version="1">MKVSHLLTLVLGAVIPAHAAFTWKNVKLGGGGGFVPGIIFHPKTKGVAYARTDIGGLYRLNADDSWTAVTDGIADNAGWHNWGIDAVALDPQDDQKVYAAVGMYTNSWDPSNGAIIRSSDRGATWSFTNLPFKVGGNMPGRGAGERLAVDPANSNIIYFGARSGNGLWKSTDGGVTFSKVSSFTATGTYIPDPSDSSGYNSDKQGLMWVTFDSTSSTTGGATSRIFVGTADNITASVYVSTNAGSTWSAVPGQPGTYFPHKAKLQPAEKALYLTYSDGTGPYDGTLGSVWRYDITGGTWKDITPVSGSDLYFGFGGLGVDLQKPGTLVVASLNSWWPDAQLFRSTDSGSTWSPIWAWASYPTETYYYSISTPKAPWIKNNFIDVTSESPSDGLIKRLGWMIESLEIDPTDSNHWLYGTGMTIFGGHDLTNWDTRHNVSIQSLADGIEEFSVQDLASAPGGSELLAAVGDDNGFTFPTKNDLGTSPQTVWATPTWATSTSVDYAGNSVKSVVRVGNTAGTQQVAVSSDGGATWSIDYAADTSMNGGTVAYSADGDTILWSTASSGVQRSQYQGSFASVSSLPAGAVIASDKKTNSVFYAGSGSTFYVSKDTGSSFTRGPKLGSAGAIRDIAAHPTTAGTLYVSTDVGIFRSTDSGTTFTQVSTALTNTYQIALGVGSGSNNWNLYAFGTGPSGARLYASGDNGASWTDIQGSQGFGSIDSTKVAGSGSTAGQVYVGTNGRGVFYAQGTVSNGSGGSSSSSTKPSSSTSSSRTSTTLRSSVVSSTTRASTVTSTRTSSATGPTGSGLAGHYAQCGGIGWTGPTQCAAPYVCQKQNDCEYCHVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C959</accession>
    <name>A0A2T4C959_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_252862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C959"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="17568" checksum="6017930C1080DD2E" modified="2018-07-18" version="1">MPTRDGAQCSGSPPLSLPRCFPLLAPLSAHGGSRRLFSLAIAVEDMKDWMRIRWCGWVPAATGVVGNCPGVQRAVERTLSIDDRANTQDTERQQTSNNHTDTIPSAGAGSYASAALQLQHPPPAPAPVLGSLQIRVPVPSARAATVWRLGLSPVSGRLSRVGTRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9A9</accession>
    <name>A0A2T4C9A9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_254712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9A9"/>
    <dbReference type="STRING" id="983965.A0A2T4C9A9"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36284" checksum="4B5AFD051E1394AC" modified="2018-07-18" version="1">MRKDLKLAFELAAEQNPLEHYKEILQSFQEELIAQEEAKKEAAATPKKSKKGKAKASDDEDVDMDDVDEAPKPKTKKRKAAEEDAAVPQRSDSAKKPKIKLNTSSTSKAANGTAAPKAKEDKAAKIAKAKPKKASDKKDAPKEAKLTPEERHARKEKEILYLRHKLQRGLLTREQQPREEEMKSMSSFIDVLEKNYDDLEVSIIKSTKINKVFKAILKLDSIPKEDEFHFKKRSQALLDKWNKLLSNEPAPANGVNGAPEAKESGKPTENSGEKESGDKDKEAQDEKTKDAAEESAAAAPAKDEEAETKEDVSLEKDEKAEPEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9G6</accession>
    <name>A0A2T4C9G6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1420307</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9G6"/>
    <dbReference type="STRING" id="983965.A0A2T4C9G6"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="377"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="549"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB78152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="700" mass="77574" checksum="90C955E60DC1770A" modified="2018-07-18" version="1">MCGIFGYVNYLVEKDRKFILDTLLNGLARLEYRGYDSAGLAIDGDKKNEVLAFKEVGKVAKLRKLIDEAPLDLTKVFDSHAGIAHTRWATHGPPSTLNCHPHRSDPNWEFTVVHNGIITNYKELKTLLTSKGFKFETETDTECIAKLAKYIYDQHPQIGFTDLIKAVIQELEGAYGLLIKSVHYPHEVIAARKGSPLVIGVKTQRRMKVDFVDVEYGEDNLPLSAEAASQTVALKKDGELLAPSSALGAPDKSLLHRSQSRAFMTDDGMPMPTEFFLSSDPAAIVEHTKKVLYLEDDDIAHIHEGSLNIHRLKKADGSSNVRAIHTLELELQEIMKGKFDHFMQKEIFEQPESVVNTMRGRLDIANKTVTLGGLRSYIATIRRCRRIIFIACGTSYHSCMAVRGIFEELAEIPISVELASDFLDRKAPVFRDDTCVFVSQSGETADSLMALRYCLERGALTVGIVNVVGSSISLLTHCGVHVNAGPEIGVASTKAYTSQFIAMVMFALSLSEDRLSKKARREEIMEGLANVSSQIKQILELDQPIKDLCQKVFKDQKSLLLLGRGSQFSTALEGALKIKEISYLHCEAVMSGELKHGVLALVDENLPIIMILTRDDIFTKSLNAYQQVIARGGKPIVICNPGDEEFKASDALKIEIPKTVDCLQGILNVIPLQLIAYWLAVLEGLNVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9L4</accession>
    <name>A0A2T4C9L4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1372716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C9L4"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="928"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="928"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1089"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1141"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1317"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1328" mass="145754" checksum="A389CFA24AE1CCE4" modified="2018-07-18" version="1">MAALRSPTPASRDATPELLTPRSKIRALLATVGDSDDEDMIQNGILKPDTPKSSAIAQRTADGSDSNSDSDSDVQIRPRGKLASRMQGPSETVDKPKTTNNGETARDRVRRMLEQEKEQPAEIDAELAGAEGADKEDYDDDDDEDLPVAPRRLQRRAANDSATELPARSPSPGLFVSSPVRPSPTRAPQAQSDSDDSDDLPPVKSDRFKALVERKRQERLAKEAEEEARKAERRALQEKLASELEDLDSGDDDAGGITDDEGGRRLTQEARPTRKASKKALEEMNRETQRMARNMQLAHEARTRKKLSKASLFERFNFRPGGEALPAEPTTNSSSRPVSPPTDADANKETPPSSPPAGEKQDLAQVGENAPADPDVSMTDGRAEDDQPSLPTRLDKGRGPAIDVKEPSKPTQTKRRVRVRLPIPTKAGAGDSDDELEITTTTKDRVNAVFNSIPFRKAQESHSILALRALANVTSPGKEKKRKNEREGMTPGEFQASLLQKAREQARLERDRRLEMLKAQGVVIQTSEERERQMQEVEDILAKAREEAQRIKEEEVAAEKKARRENGEADPLAWDDSEDEEYVGDDADEEVPDVELSGSDEEDDEGDEEEDEEEDDEESEDVVAGSAMFEAEAEDAQSETSGVLPTLRNREAEDEDEDEVIEKATPLKRRRPRNKTAILSDDEADPVEATPKSHKTPLKSSFKSPAAPTSVLRSAKKTFIPGLPVQGPAGLSLTQIFAGTMDDNQRSQLNEPTQSMMPDFDSFPDSNFSATMDDNVDDMVLDSQRDETQGETQAVQLNLAQTQMHGLDSLLRDDMNSQISDMIEPSQDGGLQRYTPLKSRFVEPPTSTVETISVDQNGEAIESSPLVRKGRLRRKMEMVSLDDEDAIPMSGEKGAEEEAASSKTAFNILKDAAAAQKKKKLIEEFNKKKSKAKEMVEEQAEESEDEYAGLGGADGEASDDESDASVQDIIDDAAGNDVDERKLAAFYADRERMNDEKEVEKLYKDITSGMLRRKRGADYDLSDSDDDGETRRRMKRRQFAKMQKALFSDERVKKMAENPGNQAFLRTIEDRGSDDDMDFLEITDAPALQSEESQSQSEGSEQPRTIPDSQPRRPLGSAGDNRAPAHMRRTKDGKKPSNIGEIRETLSDLLEDGRHESVIPATEVGSDSEGEEERPASRGNKENKYPASRRTRNVVVDRISLKRNASSSLSSSTGRLAFTASGSSSFRVPGSLLRRATTNSSLLSTASTSSSSTTTTALAGGGSGGGFGEEAKIKKGAGKKSGINGFARDNEKLARMQENERRREEKKVRGAASRAGLVGGLLGKGSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9T5</accession>
    <name>A0A2T4C9T5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1189277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9T5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015636428" description="Secreted protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17992" checksum="C6B7BCD5222F2DE7" modified="2018-07-18" version="1">MLLRDAQHHRHTCRMQMRLLMLFIAIVPGSFPVPSKRNLGVRVSDLPSSRVTRQYYFFFVHHTPHSHTPHILIPSCQLRPGCFRAPKTIQTPVRLNALLSLEHRGPPLIGQPAAEPGEPPLLLPQPRFSCCTFTTKRCAAIRPIRSDPAQNPVQSLLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Y8</accession>
    <name>A0A2T4C9Y8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1351676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Y8"/>
    <dbReference type="STRING" id="983965.A0A2T4C9Y8"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="277" mass="30811" checksum="3BF0AF93C193871D" modified="2018-07-18" version="1">MGSIGHGENYILGRNFIESVRLDAQHFLYRLQNGYTVDPRIPIGPDTRIADMGTGTGIWLLDVASQVPPTVQLNGFDISDEQFPCQTSLPSNMTLSVMDAFDEVLEQHRGKYDIVHMRLWCAIVQDGDPSALIKHATQLLKPGGYLQWEDISSSPQHMVMKGAEVEALYSYLARIHDAFRIELSWLADLPTHAKRAGLDVVQFKMEPFLPHCVPIVTKTFLMVHNGFMDAAYKAGLPFLPPREEVDHLLAAAHHAVKNGASYHSTPLSLLAQKPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA07</accession>
    <name>A0A2T4CA07_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_260157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA07"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="23637" checksum="9979E5122B3AA5E0" modified="2018-07-18" version="1">MLSRSSRDGGERRCRGGRAGGGPKFLRSRLGGLGSFFSLFLFFFLYTRDYAAPASQGGGGQFSTGTAWRCVSTCTPRMGNLASNRPCNACCNAEEVGVKNDICVRIYRRRQIDHGLVWFRQTRPDRTRAVAAKVSTRRESGRVANRGAISALGHGPQPPCACREKAKDRRRKRGRRAKPCGAVLATSMTCGLGGKRCRYGRRTSRRETRGFHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA50</accession>
    <name>A0A2T4CA50_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1429390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA50"/>
    <dbReference type="STRING" id="983965.A0A2T4CA50"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="289" mass="30159" checksum="8F89548AD90A3ACF" modified="2018-07-18" version="1">MSSNKMQQWFPWTEAPVIVNAPMAGAVSPELAAEVSKAGGLGFLACIADFSEGSHQVIKLDVDLIKIRQLLSSPSSSATTPAGHLRIGVGFLTCHPSIAHFAATALPIVKKHRPAAVWLFAPHERIRPQGEIVRLLKGLGTAGGEGEAPRVFVQVGNVAAAREAIADGADAVVCQGTDAGGHQFRRGMGVVPLLGETRRLVDDEEKGGHEGVCVLAAGGIADGKGVAAMMTLEADAVVLGTRVCYPPTFERINSKKKTKGPAYTLTCTQFTGRGDRIGEQGAACGRDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAF9</accession>
    <name>A0A2T4CAF9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1373143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAF9"/>
    <dbReference type="STRING" id="983965.A0A2T4CAF9"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="239" mass="25682" checksum="E5E8610AD5DD407E" modified="2018-07-18" version="1">MRFLCLHGRGTSAQIFELQTARLREQLSDHEFVFIDGVVETEPSEGAEAVADEFFGWFDQPVTPTHTRQVLQGLIDFITANGPFHGLMGFSEGGIVAATLLAHDARERFAGLECGILMSAAPPLDPAGILEGQEDPPTLRCLTPAVDGTAIRVPTAHVVGANEPFAHLVSLSPLAGVLIGGGLEDPEELHQLLFHLCDGSRRERFVHPLGHEVPGARSDEGLAGTVRVIERTIERAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAJ3</accession>
    <name>A0A2T4CAJ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1196581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAJ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CAJ3"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1003" mass="114011" checksum="A8BB37C332018EE3" modified="2018-07-18" version="1">MGKLQDVTRLLMAAGGSPSADGKVTYLFREKDNSLYMETWTGPELTDNVRVVSNVRSDTPAPLVFLQYKRIFTVDKSNMLRCYTETLSAEDEDEDEDEDGEEDEDIDWEEEELDDVEVEVHPQSCLAVSCGDEAIIVLYQNPDGSLGAIEDDGIGWKLSELPTCAASPGSPLACLRAEEASYFVYVGVKGTLRYLEHGADGWKDASFSNVKINAAKSKLFAANDEGSSGNPKLMVLCLADNKLSAIKLESDEPEILGTVHNGEFKPASDQENAYEHAFSLLSYVPYHVNQVLQGLDGLLSLLPRRPYTKDPDYAQGPYPYPKDQDPYYAQDPYLYPEDPYYTEGPYPYPKYHDPYYAEDPYQPPPQPRHQDSPYVPPSAPPPSHQRPPYPNSPRASQQHPQQGIPYAHPPYHSDARPNQETTQRPPQPQRATDTQAPRRNPRSQQGPPRPTVGPFDEAAEGRTEEHDGGYNDHDEVPVEEPFEEPVATRPVSSARQPATRSAQGSLQQGPAQQQSRHGPNARRQPLHRPANEHNEEFEEAPLHEESLEERPVEEEVPIEEELIEEEVEEEEVPLEQSVRQPAIRSTQRPAAGNTRQPSQQGRQQQPTTRQQPPPQRGSRQPNDNEELDEELREVQPEENLDEPFEVYTSPRLAQSAQPPTSRNVQNPLQQQGQRQPPRQPSRQQPARQEPVRQNLPLRQTARLPHDEFQGVFEEALEEASEEPLEDEESWSGPPPTRPGQRSAPGLAPRWVAPGFAPRSAQNAPQPQPPRQQTPRPATARRQPTQQDPVDPQTQTPQEQQQQPRQAAAQQQPPRQQPPSSEQFEVPYRSASRISLRHQQSRQSAWIDEDFYEYGPQYPKQEPQFRHMGDVPGQYQQHHYPPQLDSRYIHPGPYPPSHSPYEPSAAHAHHRPPHGRLPHYVHSVHSHAHPLNSHGHPRRCPSHPNHHCSCSYHPKPSLRIRMMDYLFGNRCKSCYRRYKRIKRIQRHTREDVVYDHVKACRCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAM5</accession>
    <name>A0A2T4CAM5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1399748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAM5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="62" mass="6830" checksum="14E22E0D290D841C" modified="2018-07-18" version="1">MPVGGFADRPRLRMCAGFWRVIMSEADRGGGRPLVVVLKRSVHGQRSTAGQSVASRVFELSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAN4</accession>
    <name>A0A2T4CAN4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1198076</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAN4"/>
    <dbReference type="STRING" id="983965.A0A2T4CAN4"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="11">
        <location>
            <begin position="650"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="746" mass="81279" checksum="251C042D7BB75C6B" modified="2018-07-18" version="1">MYQRGVAIGKENRGKGVNVWLGPTVGPIGRKPKGGRNWEGFGADPVLQAVGARETIKGVQEQGVIATIKHFIGNEQEMYRMYNPFQYAYSSNIDDRTLHEVYAWPFAEGIRAGVGAVMMAYNAVNGTACSQHPYLMNALLKDEMGFQGFIMTDWLAHMSGVASAIAGLDMDMPGDVQIPFFGGSYWMYELTRSALNGSVPMDRINDAATRIAAAWYKMGQDKGFPATNFDTNSHHAFNPLYPAALPLSPFGITNEFVPVREDHDVIARQISQEAITLLKNDGGILPLSPSQPLKVFGTDAQKNPKGINSCTDRNCNKGTLGQGWGSGTVDYPYLDDPISAITAEADNVTFYDTDKFPSVSEISASDVAIVFINSDAGENTYTVEGNHGDRDKSGLYAWHDGDKLVQDAASKFSNVIVVIHTVGPLVLEKWIDLSSVKAVLVAHLPGQEAGKSLTNVLFGHASPCGHLPYSITKKEDDLPKSVTKLIDSEFLNQPQDTYTEGLYIDYRWLNKNKIKPRYAFGHGLSYTNFTFKAASINKVTKLSIYPPARPAKGNTSNFAQSIPSAIEAVAPSGFDKIPRYIYSWLSQDDANKAISDGKTGTYPYPDGYSTTQKPGARAGGGEGGNPALWDVAYSLTVTVQNTGDEYAGKASVQAYLQFPDDVDYDTPIIQLRDFEKTKELKPGETTTVTLTLTRKDVSVWDVVAQDWKVLTVDGGYKVWVGDASDSLSIVCHTDSLQCETGVVGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC60</accession>
    <name>A0A2T4CC60_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Endocytic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_64283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC60"/>
    <dbReference type="STRING" id="983965.A0A2T4CC60"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="139"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="13">
        <location>
            <begin position="291"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="12">
        <location>
            <begin position="1106"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="708"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="927"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB79140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1147" mass="121395" checksum="7FD1BF507CB39787" modified="2018-07-18" version="1">MSAAAGVAPSVPNLNLREDERAFYDRLFSQASRDGDKVTGEVAVQLFEKTTLDSSTLGTIWQIADIGNQGFLTREGFYVALRLVGHAQAGKQPSPELALQPLLRGRLPEFAGIPPPQVQPPIVPQVSGGNHIPPLSAEKGDRYVALFAAQNLHNKLLPGEQARTIFGKSGLPNEILGRIWSLADTEQRGALALPEFIIAMHLITSFKSGDLRTLPNVLPAGLYEVAIRIASAAAPRQSPANTGGITAIPRQLSGSAQQQRTGSPLNRPPMVAAQPTGVAVPNNDWAITPADKARFDQIYLDFDKTNKGYITGEEAAPFLSQSGLPEDILAQIWDLADFHSQGKLTREGFAIAMYLIRQQRSNRGIPLPATLPPNLIPPSLRAQSRPTTAVSSAFDPPPVAAHAAPAAVPVPAPPAPKSALDDLFGLDSSTPSPAPPAPAQTTMSTGGSNADPFAGGSGVLHPASPSAKPSSPVGVTFRPFVPSSSFGRGLAGHPGAEQSRPHTASEDLLGDTDPEASKAISNETTELANLSNQISSLAKQTQEVQAKRTTTQHELSQTNSQKQNFEQRLAQLRQQYEKEAQDTHALEEKLRNSRADTKKLQGECMNLEGQLRDIQGQHQQVLAALQADQQENANLRERIRRANAEVAELKPQLEKLKLDARQQKGLVAINKKQLSTTEGERDKLKAEAEALARSAEDISQSRQLSSSFLPFPEHNESLSSSRQVSPPTSSRAEGSASGSYPFPGGASSGEAEAGAPAATASSEEEEKHDSASATPVPAAQGDSSQKPAEGEAQDRSGSFDNTDHAKAKADFDNAFAAFTSTKAPGSGADKESAAVKPQSAFDNAFDTEFPPISELERDVSESDSETGGFDDDFAPASPENKAKEKQAASEPTPESHKPTTETSDSAAPAPPSQDVTASHEGEAKSAELSSSPATITNNNAIPQTSNADDIFGSSTQPAPGHQNQHPASKGAFDDLDDEFEGLEDAKEGSADDDFANISRSGLDDYNPMFDSSPPASQAKSESTAFGNESSFDFISSNSAASATGQSSNGQQRGAEAHDWDAIFSTLDSPTVPAAQPVQSNNTGPPKEESADTRPPAPGRALTEAGEHDDPILKNLTSMGYSRPDALAALEKYDYNLERAANFLASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCG5</accession>
    <name>A0A2T4CCG5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DENN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1436586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCG5"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="241"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="876"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112041" checksum="66A910D9B48A1E1B" modified="2018-07-18" version="1">MEGSSTPLAEYFWIAGIEAVIYDESLPPVTHSTETTTIVEDGEAEEEEDAASNHTKPSAARHSRQNSANRFSKLSINDRNSVHTIEEDDGNTRSNRSSATIKVKPAAGNGTGFPNGDAASNGGSMGEFLGLMGDFDFDKALLKFAAERENFLEDLSFSAGAKTQARQPMVSPRAERIRADEADSSGRVSPLRSIKGSIRRKISFRDMNSLRKQPSVARPMSQRAPSIRTTRRLSNYNSVIPPPEPLNTDPDMHPLKRRFEPMLLDRYPPKTATEEVARRGKFPDYVPMFAFPNDVQIVSSDDRPRSTWHGFTMTSDDNSKLYGITLIVWTALPADVAEVVENKCEDWRQSHMSNEERELAASLGVRLAGERSHLSQLLAKLGTLPSGSPARDRLEDEIGTVEEKITLMTDMLRPLRHGAASRIEGLTTGESGLWAPRAYGILGRDPANMAFWKEWLKAIVVPMTDGAVLRIPPSSPKVGRWQPLEQYVVNLCTEAFSPLGSKTQVEIGVRELRLFSRKEAANEIPGSRTIDIYALFRCLSLENIVALFEYAMSESRIIFLSSHTSMLHLACHALANLLYPLKWASIFIPILPARLISALDAPCPYIVGVERRYERIDLPEDDYVLVDLDKDTIDATSQPIRLPRQHRRKLMSLLQVAAPHKLRYGVTTGPPPYAMEAFPYDSFSSENASLFTSVAPPSTLGKWVSQNSSSFADPDPPNEVLPPVFNGFSVSSVDNGKSDRPGTSKSNQTSPQSSVSPVSMKFPPMPSTPVSRSDSGFALTSTLREKRSGHFGEDKGRRSSSFGVDKYQPPVHRPSLPFLNGHQTNLSISTLDSQSSFGGGYAPSTYAASTLAASTIMPNMQIQPVSNTDTTVWVEGHCFNWNPKDTASVCTICEERSEGDGFYKCGACKTVAHGRCLGFVSLVCPEAFHADRVRAAFVRCLASLLFTYRKYLGKPSKQHKNSGQLYTFDMDGFIKSLPYDQQEYPRTIQGVPRVEPRGPRGVARKQVPNMGSTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCS5</accession>
    <name>A0A2T4CCS5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1398614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCS5"/>
    <dbReference type="STRING" id="983965.A0A2T4CCS5"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="30"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="348" mass="37496" checksum="72BAE19535357185" modified="2018-07-18" version="1">MAPNKEFALICLENPLLDIQAVGDQALLDKYSLKANDAVLAEPHQLGIYEDLLNNYDAKLIAGGAAQNTARGAQYLLPANSVVYLGGVGDDKYAAILRDAVKAAGLRVEYRVDDKHPTGRCGVVITGHNRSLCTDLGAANHYDLDHLKKPEIWSLVENAEVFYVGGYHFPVCPPAIMELAKEAADKNKVFVVSLSAPFIPQFFKDVVDASAPYWDYIIGNEAEAAAYAEAHNLPSKEPKDVVKVLANLPKINTQRKRVAIITQGTEPTLVAIQGEDEVKVFPVHPLDPALINDTNGAGDAFAGGLVAGIVQGDSLETSIDKGQWLAKLSIQELGPSYPFPKQTYSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCT4</accession>
    <name>A0A2T4CCT4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1770-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1371213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCT4"/>
    <dbReference type="STRING" id="983965.A0A2T4CCT4"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="18509" checksum="33496F7270140DC5" modified="2018-07-18" version="1">MATELGSTIQAGHIRRHPDPRQDVAPSTAADRRHLVDLHSAHRSDIDVSEDEDDIPYSVLRPPKKQYHLPPLPDLRFEQSYLHSIASADTWWKVLLITVRDQVLMPLAQGVLLNLALVGWHHWNKNARLHGDSVGVRLRRWWYGVNNWKLPNNTNAKRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD42</accession>
    <name>A0A2T4CD42_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secondary alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD42"/>
    <dbReference type="STRING" id="983965.A0A2T4CD42"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="23860" checksum="CDC89DA532264754" modified="2018-07-18" version="1">MSADTTPISPARFASAIKDLSLSMLHLKVLEIRNSIAHLQYSNDQLAPFAQGTSVALGGTNTDSSSAEAVPDQDCVDAIKENEAVIERMAERIAIIRAEVEERGLSWTEFQSQDEVREANDADATTTTTTNGEQQGLVNGQAPAAAQAGGSNTAARAEARHSAWTDGTFQTGTISNGQIRFDSQQPVGQQGAPTTNQDEAQASTTRGQGQGQDESGDDAAEDGGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDL2</accession>
    <name>A0A2T4CDL2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1389588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDL2"/>
    <dbReference type="STRING" id="983965.A0A2T4CDL2"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="728"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="932" mass="104443" checksum="46DD0159FF1BBAEA" modified="2018-07-18" version="1">MDAAHIFRQGLGTVAPRPNHAYAQSRNLVQSPDDYFDGDTSSHRVAHTLTACCRCRQRKTRCDPTLPRCLPCERSGSVCEYLDAAKGRKINRRYVITLQDKVRALEAELGQYTDEDGDHPPTSEELVRPGGMIRLKGNDETPRYLGPTSGIAMTRLLMAEAKRYTDTNKISDLIPEVRARSQARMQSIQMTTSGSNRKSYPMVSECPAEGLPTRPVTDRLVEIYFKKAQIHWPVLHEKVFQADVDAVYNGDTDVYRNFVIRMVIAVSLQKLDTQYAGLADGYYMAAMKYVEEVIRPKDLKTLQCLILIGQYSLLTPTRTPVYYVIGLATRICQQEGLTDEKTITSGYNLDPQIIDMRRRLVWIITTMEFGLSYYMGRPSAFAVNSDRLNVEFFSVVDDANITPQGIVPGAPNPRKVATIHFYKMTNPQAEIKRTLYERKRPEPRTDDHPWFQNMEKTLRDWLDAAPQEPAWAKSWITGFYHQMRALLYRPSPQIPQPSARAAQICYESSAATIDLSSKQIGTDAVDISWVFLLTLNLALSTLLWTISYPEVRRNHPREEVEELVNTALESLDRCAERWPGTAATSQLYTIFAKACMQSYEAQVKLEKEPFSFSSPPGTAESQSSPEGYAHSNATTPRPLTYLNPPTFGYVFDSSPESMNNYAFDPNYPPPQPTFRSNSIFCNPATDNGNRRFSYFPPDVTHMGEAGQEDPSAHGIPLPDHIPHHLQSPPDSFIQSHMPTPRPTLSPSAMAMKQTSSVTPINPSPLSAQSNMSPPQKPIIAPQVTQQQQQQQQQQQQQQPQPHPQPTYAAARMTQPVHHQRPLPPAPTSVSDWFSPPSQFMSPYNFVTSGSGYFNEAMAGMSGFGGPPGPGLGLHNITAQLEAGGMQFGYPPARQGSLSQSQQMELMEDLEKDGVSAMDAYLQDTQMNGRGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDN9</accession>
    <name>A0A2T4CDN9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-terminal binuclear Zn cluster-containing/DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1174932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDN9"/>
    <dbReference type="STRING" id="983965.A0A2T4CDN9"/>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="667" mass="75031" checksum="AE0C10D71F9C5CC9" modified="2018-07-18" version="1">MPRSSFSHTPLLRVSRPVSACSRCRAAKVKCDGKLPACTACEKAGRENACSAANDQFARGKERSYVAALELRIEKLERRIAYAKSRKASVANHESDAVPAAHVDRRDSLASIRAAIHRKAARTRENSDVNSLISDFGFLSVNATTRDFEPSFINMTFARLVLAAASKDPIPGMPESPLPHKSYATEIFHHFMKNMYPLFPCFSETAALNILNDIYSQQSERVISASDHWLLYMILAIGSTMQSQHVNDNYYNLGVSFVSRALDYADIALAPGYATQIQSLLLLTQYAILDPNHFDSWLLIGFTARAVIDLGFHQDPPMSTVVDRAALDMRRKIFYCTYALDRSISMVHARTFSFTDDAIHVAFPNPANHDRKGKEAESLPISGPQSVDPGLLLFQLRRAQSYWYQELYQSYATPLQDPSSFVWQMCLDMREWGESLPSSLAPGIRQMFEQELRYSYVYCIAPSARAPEITNYHRTLIFEYSLAYLLTMQDIAQSGLNGAYYTYHDALKVYFMANQFLAVLRDSEDMLLSGAHVPKPMSRPGAPQAPPIPPPSFRNGRPGEDNVSRSIRCLESVPQTLDVYGRRWEDSIMLKQSFEQLSADTMERLRERRKMQSIKVEQHPAYPGSSPVAPSPRVPAAATSRSPQQPREIRWVGVDVSQMMQGRGHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDQ4</accession>
    <name>A0A2T4CDQ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1420005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDQ4"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41702" checksum="9DEC8ECADCED1B52" modified="2018-07-18" version="1">MLHRPLPTSTSTSRPPALQPARPPSGSLAPNHNHSHSSSSSSTTPNRPPVMKLQFINTAHPRDSTSAKRISQIRSHVARDSHARRRQRKAANGSNACACACPTASSAASHAPAAPPAEPPARPESPDSTSAGTSSVGARSRLPTSSSPPASVTCAAGGTTAAEDEDSQGFRRIAPKTKAVARSADLPHPRKLIGDTKTDGWSFAWELSTDECKTFDFFLDWVLTYGYEICFPRDEVPRVMSRMRTTYVPFAIKHPCLLACIFYISYHRRYLNTDDPGEAARCHLLMQQYRLACIEMMKSALAVEKKPSAQTITLAMQLCSEAFFEGNPDISFTHAYAARTMVSARGGLESFDQAGVDALISFLLATSVYSGNYWFVPGCAKFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE17</accession>
    <name>A0A2T4CE17_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1180499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE17"/>
    <dbReference type="OrthoDB" id="5343483at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="302" mass="34140" checksum="B6B0A703D280F5C4" modified="2018-07-18" version="1">MASSLHPKALTASPLSINQLLRLHCRERLAVHPVEWTHRHLELLECSFGWPTPEPASGCPDALLSPDKQLEEDANARFVRQLASRRGRGAQDFAWREAQLGRILTSDEHLSIHYRGGIYFHFNDRAYNLSCILVGEYTGQRNNIPFAACIDRFDIESQRHDRMKTYRGARQSVATNSLRSLRLRKVTPINYYHDPYILALLIALAQGQRAALGSNNDAARGFRPQVLMTSYKENHVHLFSAEISSALLDRLDFPSVTPQAQGPVLIQHVLVPLKPYATFRSRLFQLLLCENIREAAHLGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEC7</accession>
    <name>A0A2T4CEC7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_174317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEC7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="19044" checksum="EEDDE5F72E475355" modified="2018-07-18" version="1">MALILCRPHDAGESALTANDAEQRSTRQHWRMWQRSKQGADAEKRSSLPDSVVSHHLSPVSPVSPTSQAPVAPAEPTAAPQMPDEAQAMMVGSVDDGHEPEDKDGEDKDREQRQGQHEDVDISPEAQPDVEAAAADDSSTLPGELQALVQASPALDQRQPQRPTTPGARVQGQKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEF5</accession>
    <name>A0A2T4CEF5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1368748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEF5"/>
    <dbReference type="OrthoDB" id="2364174at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="309" mass="34805" checksum="7ED8EE557743CF02" modified="2018-07-18" version="1">MSRLPPIEKFSLAVRKNIRDEWENKKPEYEQRLSDVLGEPWKIDIDLRQVCAYAQDGYAAESPGSMTSAYMDGVLYQLGRFIEKHGAEGKSELNTISSARTITMDLDQNKKFTYCGCKISPAGELVILFGEGYLGTNIDYACSLENLEAALNEAPNTASSRPMSFAARAAVRNDWDSEVQAVESKLKDILKKDIAVVPQFEQAFDKLSTAKDAPESWQQSLGAFLRLYFEGLIRYLEYQKFGEDDMLYEAFNETVDKATVAFRIVDKGQLKHSTYNECVIEDGTLILQTIPEYFGTNIDQAANNLMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEH4</accession>
    <name>A0A2T4CEH4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1397256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEH4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="11946" checksum="E1186EC93EC91A91" modified="2018-07-18" version="1">MFDSCDCLERQAECRSAHAGRPRNPEMCGLARLSDKLIGRLSPWADGRVPQGWGGDKMAQQRMEEEEMGFRAWCLVPVAGTCLALAVGWREAEVLGGGSSQGSLSCIMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEN4</accession>
    <name>A0A2T4CEN4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1435746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEN4"/>
    <dbReference type="STRING" id="983965.A0A2T4CEN4"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB80016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="734" mass="78248" checksum="05178690D9CA26CB" modified="2018-07-18" version="1">MASSSSIAVTTDNITTSGHVRTAGEIASHALARSFEVLRGLALGGRSSTTTTTTSIGVEADVDSNGRVYGSRSTDRAAIGNNLDARAFHNGLHLHKRHLGGGAIAGITIGVVVAVALLAICLYPCFLYLKRRRSGRSHSAFDAEAGIAPNARHGSSASGGANTPPKRLSSSDSYKHRGDLTRGGDGDGGSADYGNWQASIDGGVNNGYSYPLSAAYLQPGDPGFVDSNIAEEHRVKAQPFPLLGCDDGEFAPPMADDYQPGVLKGTSADYYSPHIPSEAFGMVTQPDAALDSPVQPPSSRSSSLRQNMMHIFRRKTGRDATIDSTISRTTIPEGAASSHLDGATPLQTLITTGDRVDSPTNISAASLPLSRSPSHRHPNAEAAPESSLAPVSPPVSNAPEPSSKATPPESPPFPAYHQFRKSPSPPIAAPGTVNPMDIMPASTETEVWHRTEHQLYEAFHKASTSDPVAFPAQESSAIPSPSPTPPEMQPQPQPIFTIQSPGATSHTGLTSDRIINSNTDTNTNAPQNHQTHSHNDNGDVAMLEAPLPPNHDHSLAAPDGRHPSYPSDHSTPLPGPSFTDVSSQNTPSTQLDTPSPESMGSSDFRHSASPHSGAGSHSPRTGAYRCDEPGCNQSFDQPHKLKHHQRYHSKDHKCPYDGCGKGFGTKTHLQRHINDRHEKKKKFHCSVAGCDYSRAGGKAFPRKDNWKRHMIKIHNIEQQQLPEPIEVDMDLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CES7</accession>
    <name>A0A2T4CES7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1388438</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CES7"/>
    <dbReference type="STRING" id="983965.A0A2T4CES7"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="443" mass="49097" checksum="6A37D36C702FB460" modified="2018-07-18" version="1">MTTRYRVEYALKTHRRDQFIEWIKGLLAVPFVLYSQPTGVFGDDSNVAKMAEEAHRRYAEIMRDVELMIDDHIARQHRDRALPSKLGMLVPTAGPFFTRLPLEAAFKYQDRKRYMSSRRYVAPSFNDVRLVLNSAQIMAVTNGTLQLATFDGDVTLYDDGQSLEPSSPVIPRLLDLLRKNIKIGIVTAAGYTTADRYYQRLHGLLDAIAESTDLDPVQKQNIVIMGGEANYLFEYEPSSPYRLAPVPRPAWLTPEMAAWSDVEIAALLDVAESALRDCIRTMNLPAIIVRKDRAVGIVPNPPEVRIARESLEETVLVVQRILELSALGTPSQQAGQGAQGRHGVPFCAFNGGRDVFVDIGDKSWGVTVCQQWFGRRSGATTGADAALTAIRGENTLHVGDQFLSAGSNDFKARSVGTTAWIASPAETVELLDELADLMQKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEZ1</accession>
    <name>A0A2T4CEZ1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEZ1"/>
    <dbReference type="STRING" id="983965.A0A2T4CEZ1"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27478" checksum="9A9C9FB102D23B63" modified="2018-07-18" version="1">MSNSKKRAAEDAAPAKKAKKRKAKHAVDDENLDTELGLNTLFSKMDSQLLADYHAQKLARFGTDLSPVELSDLALSASSITDTTSWQETRSLEKLPDFLEKFSEHPESLSRAQKKNGMPHTIIVAGAGLRAADLTRAVRKFSGKDNLVAKLFAKHMKVEEQVALLQNKKIGIGVGTPARLMELIDNGSLKLDKLQRLVVDASHIDQKKRGVMDMKDTMMPLARFLARKEFKDRYADEKKPLALLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF79</accession>
    <name>A0A2T4CF79_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_186949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF79"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14273" checksum="E03E652352EA1A8E" modified="2018-07-18" version="1">MSYRACQGTYVGVASFLTLFMFLPAVPVGLAIFSSPPLMRLPRISCFSRLPRLWLRAKPMAVSSVLLPSTPFPHLCISFFFFLFLFFCFSISDYLIVVIDHRLGKAAVKLERNRGRDTCFGPRVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFF2</accession>
    <name>A0A2T4CFF2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFF2"/>
    <dbReference type="STRING" id="983965.A0A2T4CFF2"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="399"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134450" checksum="9A2FEC32C66E7B04" modified="2018-07-18" version="1">MSSIALRRPQPAPRRASTRHESVSPSTVTPLRTFAVHRTHATADFTEADEDEDEDEDEDEGRRFENSGNNNSNSENNNGTTTGLFDNNNDSNIRRRPGQAYGNDNAAARDQGGRGDDGEEDRPPRRRNTLPVLPLFSSTHLDTLPVYSLTHAIRIIVSARTETTLTWDQLRSPQVSQFLIKPMQQQIRNQHFSRATLYALMANCLQFTKEAQMYAANAGTSNTRAKVCELLALKLLKEYSTRELIDALAYDFYPLQGLPGSQAPPRTAGSANSRSKNTLLVASRTSTLEVAIRASAKHFLAHPVVVQQLEAIWNGAISFYSSADSLHRESPSNPFSRFNSQPKVDDRTPLLGSLPPKQGHFAVPPGRRTVMLYDPRQASLLKLSRLRVPRYRSFLSTLSLAVLIGLFLAVLSQRSAQITGLELVFWFWSAGFMLDELVGFNEQGFALYIMSFWNIFDLGILVLLIAYYCMRVYGVFLADPYHWNAMAYDVLAANAILLLPRIFSILDHYQYFSQLLIAFRLMAADLAAVCVLILIVCSGFYVFFTSSTASSDGGEVAYKIFQILMGFTPAAWDVWPTYNWLARALLCLFLIICHFLIVTILITVLTNSFMAIASNATEEHQFLFAINTISMVKNDALFSYIAPTNIFAWLLMPLRYCMPLRHFVLLNRVIIKVTHCPILFCIYLYERFWLAPSMFEPTDLVENPGRNRAISFGDMANRTNIFSPSMRVREESVAGYQKDRALDELFMRMPEATKTQRRHERRKTQTAIRNWMDRNDQEGVGSNWPPSDSRAVPDWQRRMSMGWDLRSNSRQMSDLRSIVSDPADLASNAGGTSYRAFPMVDPRFMDPRFAHLMPEYKDHTDADGDDELVTNDEDEDDLGTSAGPHGPAGGGNAAPSETDDYFATTPTGARSAVIASSHSSTDKGNNSGKLRRRELHNRTMSTNTILYNPGEMEPPTESSQSASPPKAGVPAGESSTPTGVRSPPRRALLSPPSLNTRSTMPAHGLVGMSNLNRSAMLGHGSGSRDRAFRRLSSADLSILSDNTNLPFAGDINAGLPGSFQTQMAMAMMKDNRLRSSGESDAADRDRMGRLVLARMKTLEESFADVVKEMRDLKSSSTAPTTRRNSSGEDLRMGTSPEIGRPDRPKSRRGTATPKKATSKRPASRWSTKESRLGLTMKGDVKGKGKYIASSTEEEGEVAGEPLLEGRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG98</accession>
    <name>A0A2T4CG98_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG98"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="11825" checksum="F1351B71F0E37E94" modified="2018-07-18" version="1">MYISELQCISSCIGASCYSCIRDSSPEEEVAPVDRAVPLAQAQQRLKVRKRQQTLGSTPFASPSVPANEGAVPAPSPPLESSRTCLTPPASGGPALSGAITGPAGPLFMLWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGE2</accession>
    <name>A0A2T4CGE2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lytic polysaccharide monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGE2"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="232" mass="24879" checksum="5BD326838AA89750" modified="2018-07-18" version="1">MAFLLATTQAHMEVSWPPVFRSKYNPRVPGNLVDYDMTTPLKADGSNYPCKGYNVDAGRPEGASGVTWRAGSTYNITVAGSATHGGGSCQASLSYDRGRTWVVVHSWIGGCPLTPTWDFTLPNDTPPGEALFAWTWFNKIGNREMYMNCGAVTIRPSGYRARSPADSIYNRPAQFVANVNNGCSTLESADVLFPNPGPDVEYDSDGTAAPVGNCGASGRRTRPGRGLSGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGQ4</accession>
    <name>A0A2T4CGQ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1370179</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="5"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGQ4"/>
    <dbReference type="STRING" id="983965.A0A2T4CGQ4"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB80730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="128" mass="14174" checksum="FD179956B5FBECFF" modified="2018-07-18" version="1">MPASVGTPQTLYDKVLSSHIVDEKLDGTILLYIDRHLVHEVTSPQAFEGLKNAGRQVRRPDCTLATTDHNVPTTSRKGIKDIASFIKEDDSRIQCVTLEENVKEFGLTYFGLGDKRQGIVHVIGPEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHN7</accession>
    <name>A0A2T4CHN7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CNDP dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_45615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHN7"/>
    <dbReference type="STRING" id="983965.A0A2T4CHN7"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="217"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB81032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="476" mass="52357" checksum="F986FB52773AD080" modified="2018-07-18" version="1">MAPQLDSFFSQVDSSADHFIERLRKAVAIPSISAEDARRPDVVRMGHFLADELKALGAEVELRPLGKQPHKEYLDLPPVVLGRYGNDKNKRTILVYGHYDVQPAEKSDGWATEPFELTVDDKGRMFGRGSTDDKGPVLGWLNAIEAHQKAGVDFPVNLLMCFEGMEEYGSEGLDDLIKAEAKKFFADADAVCISDNYWLGTEKPCLTYGLRGCNYYSVEVSGPGADLHSGVFGGQAHEPMTDLVQVLSSLVDSKGKILIPGIAEQVAPVTPEEEKLYDSIAFTMENLHESLGSTTTIHEDTKPTLMARWRYPSLSLHGIEGAFSAPGAKTVIPAKVIGKFSIRTVPNMDIDTTNAAVYKYVEEQFAKLGSKNTMKVYAQHTGKWWVASPKHWNFSAAAKAVNRVWGVDPDFTREGGSIPVTLTFEEATGKNVLLLPMGSSTDGAHSINEKLDKRNYIEGIKLLGAYLHYVAEEPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHX8</accession>
    <name>A0A2T4CHX8_TRILO</name>
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        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1009364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015517507" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8770" checksum="489C3301550B803D" modified="2018-07-18" version="1">MLFFSPLAAYILRLPTLLFSFQAGRNSICGEKKRRKATQRKATQRLATGQPRITSTSTRPALPPEPAYYCPPAAVAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHZ9</accession>
    <name>A0A2T4CHZ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5405126at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="340" mass="38099" checksum="BCA428118C95D441" modified="2018-07-18" version="1">MNKILASIQETIILPAYLPEKQRKLVFDPKMKTYLEQNPIVIEVEGLEHKFSSIDRFRDIDNSKRILSKALASMRSRDDWANLGTLLAGYKKAGIRLKANHWGKIVRMAGQSGNILAVIECAKQAEKTGLLLTNPETVVRILSYVNDKITDSRWGEAETKQAQKWADQVLDLLQRKEHAVEGQPTRERLHFSRLVRGMTLFTRASAIKVKRDAGEPVVLDIVLLRDEIQLLASLWKGATDANLEELPDFAKLNPTLERNASPKGVKIPKALNGSAYVQVLAQNIKGIELAREIVGGEAQVLAPVEDALAKHLRHFVKTSKSSTKGWAEEYEKIVGEAPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIF1</accession>
    <name>A0A2T4CIF1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1396451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIF1"/>
    <dbReference type="STRING" id="983965.A0A2T4CIF1"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="92" mass="10316" checksum="9A44291891E313F2" modified="2018-07-18" version="1">MSSTGVNVLRWSALAFGVFYGFSHQRTITATQRAQHAQHEYEQKQKLIEQAKAEYAKKKAPAAASDNDAATDVNSPEFDLEKYLLKISKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIT3</accession>
    <name>A0A2T4CIT3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_84931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIT3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="16067" checksum="D84E9C6797565C16" modified="2018-07-18" version="1">MGSPLDPWRLSLACRPRIRPPERSEGGLGRDRPGESGMLVVSSPIRDCPCDDDLLERRVHVWRGAMRRVIYYYLIPGPNWFFCMPFSMLKIFFCFCFFWLFLCVRFGFFSHLHIYTHARTHTHTHTHTHASGVLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ57</accession>
    <name>A0A2T4BQ57_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1150362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ57"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ57"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="104" mass="12366" checksum="7EE82368E943B8CF" modified="2018-07-18" version="1">MTPEFKREWQLLRMRKVLDPKHQKKALRAAVPEFSQVGRVVENPFEPRSARLSSREKKKTLLESIMSVHNDSKLDSKYSSVQEKKREGKKAYYKSVVAKRRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ88</accession>
    <name>A0A2T4BQ88_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1406468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ88"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ88"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="55"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="342"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="479" mass="54281" checksum="ED3B8A151352EC8D" modified="2018-07-18" version="1">MDPGRRAMIAEPRGSPPSRRDRDPTAPRPDSNSRVSKPGRPGPSTTARNAARYLSQDEQSRQFVADEDKFVLKQAKKKADIRVREGRAKPIDVLAFNLRFIDADRDPFDDEDADDEIQVDAPAKVIEDLTSAAQISELDSSIVSYHVLETDPRNRRYWEALRTLCADRRAKLDPQGHEGRVVSSVADDIDKILAPKTIDQLETLEGQIKAKLRSNEDIDTDYWEQLLRSLRVWKAKATLARIAEEIEAKKRERLAKRAPSSTTTTTTAEAARSSGVSGSSSSHRPGGGLAPANKVDVETGNEDDSQATMALYDREAARGVSENEEVFAAEEALPGGSKPPQWMDKYQPRKPRYFNRVQMGYEWNKYNQTHYDHDNPPPKVVQGYKFNIFYPDLVDKTKAPTFKIIREHGRRRGESFAAAGEVDTCLIKFIAGPPYEDIAFRIVDREWDYSAKKERGFKSSFDKGILQLHFQFKKIFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQM4</accession>
    <name>A0A2T4BQM4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1343721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQM4"/>
    <dbReference type="STRING" id="983965.A0A2T4BQM4"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="44"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="343" mass="36822" checksum="048786BE4B2A9FD1" modified="2018-07-18" version="1">MFSFGRSRAAASALSAAKRATPSVRLPGAAQQRRALSIHEYLSADLLRKYGVGVPKGAVAKTAAEAKKVAQEIGTGDLVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPHEAEMFAQQMIGHKLITKQTGAGGRLCSAVYICERKFARREFYLAILMDRASQGPVIVSSSQGGMDIETVAKEQPDAITTTYIDINKGVTDEIARDIATGLGFSEQCIEDAKDTIQKLYKIFVERDATQIEINPLSETDPKVSAIFVNIFGGIVRCDAIATGLIRTVEALNLKIPIIARLQGTNVELAHQIINESGLKIFSIDDLQSAAEKAVQLSKVVKMARDIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQY7</accession>
    <name>A0A2T4BQY7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1343654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQY7"/>
    <dbReference type="STRING" id="983965.A0A2T4BQY7"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="38132" checksum="FD49D44C8A29785F" modified="2018-07-18" version="1">MSQALPKIVTRALGKNGPRVPRLGLGLMGLSGHYGLPAPDEKRLAFLDKAYEMGETFWDTADMYDDCEDLLGKWFSANPGKRDNIFLSTKFGLRTEGRNIIVNSSPEYCREAIEKSLKRLGLPSVNLYYVHHLDKVTPIEKTIETMVELKKEGKIQHIGLSECSADTLRRASAIHPIACVQMEYNPFTLEIESPQRRFLETARELGIAVVAYSPLGRGLLTGTIQSKEDITKAGDMRSMLPRFSGDNLERNLATVAKINEIAKNKGVTPAQLTLAWILAQGDDIFAIPGTTEPDRLRENLVAMSISLTAEEEQAIRKVATEVVGPRIPENIPGVNLFGDTPPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR67</accession>
    <name>A0A2T4BR67_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1442306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR67"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="538" mass="59380" checksum="1B35F1122CCF2D0D" modified="2018-07-18" version="1">MAEADITKVAASHLEDKLGEGAIIDAKNASDEEHSQTLFQALKSNRKAVFWSMLISMSIVMEGYDTILMGNFFAYPEFAKKFGTDYGGTVGYQVSAPWQSGLNMGSTVGAIFGGILNGYLVSVFGYRLVLVGALFFMNAFIFVVFFANSAAVLLVGQILCGLSWGIFAVASPSYASEVCPTHLRGYLTTYVNLCWAIGQFIAAGVLEGLIHRRDQWAYRIPFAIQWVWPVPLMIVCFIAPESPWYLVRKDRVEDAKRSLRRLGGNKTDDQISGQLAMMVHTVNIEQVQAKASKSYLECFRGTDLRRTEICCVAFLGQILSGSSFAYSPSFFFVTAGMSPDHAYQLNLGGTAIAFLGTVFSWFLITHFGRRTLYVVGQGILSLTLLVIGIINSATSAKDAIWAEAALCIFWLLVYALTVGPIAYSIASETSSIRLRPLSVSLARTAYQVINVASQVLEPYFMNPTAWNASGKTGFFWGGTALIMFVWAYFRLPETKGRTYEELDILFARRVSARKFASEPVDAYEMSPTFSTAKEPHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRE7</accession>
    <name>A0A2T4BRE7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1343311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRE7"/>
    <dbReference type="OrthoDB" id="10568923at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="10729" checksum="FDC95B943F375BA3" modified="2018-07-18" version="1" fragment="single">QRLSTLDPRGDVVIGAIFSSKIQGPRLMRQEHVLELQYTTILDGTMSMKVYQGTSFYPALKFLLYDAVNRNIAYKGIMVAQPNPTIFTIPSLAIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRN9</accession>
    <name>A0A2T4BRN9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRN9"/>
    <dbReference type="OrthoDB" id="5411518at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290:SF6">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41588" checksum="C75C5C8DE5393C20" modified="2018-07-18" version="1">MSRTTKPPRCAGNPSFDPDEVIQDLPRLQQARELLAANDLYNASRVLLGLPERDTFTYHAMTSVTLAQVQHVVGLGGLNGLHAWYRGEDGTAREPPPPPDIEAYIAIFDPATATASALKNFGTNAKKASIRSEVAVHLAEKRYVHPALLSRLTVPKCKRPPSENPSLDFWAWSCRSLEWCGPCASSERVATSHHVLPILMHHFGCATPSHEGLEVLRLLADGRPVADVGSGNGYWTFLLRRYGLTVYPVDNMQSEWRVNWVDDTAIADGVKWLRKRDGGRDMVLLLVYPVVGGGVGGGAEGGFTRGLVDAYQGDTLAVVGTQNGNGYTGFRSMTMDVYMEREHPEWTKVVQIPLPSFAGKDEALFVFQRGARAPSSSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRY2</accession>
    <name>A0A2T4BRY2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_61107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRY2"/>
    <dbReference type="STRING" id="983965.A0A2T4BRY2"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="143"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="437"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1247" mass="141686" checksum="1CF9F1E1449C0E73" modified="2018-07-18" version="1">MEVHLNNVPKGLTDDKLRNELEPHIKALGIRDWHCEKPRNKLHAWVTFLYEADGKRFLQKHEKVPMSPAQPRGPPIANGRFQSRTKDMARLEIFKTPIFVKKSRNEADDTILLHLRIQQEERKSVEQKPVIVDRNPKAPPISTNIRHIACGKNMFDQESDALVFVEQCSLDQRGTAKFGRRALMLSFSGTDEYRVDFPYDVIQDLVAEASDASMTIVLTEAPRFYRKVPATYPSRSPTKWIRQTALDMWPAHSKYVAHCLVYRITLSSHYLDVLEGLRSRDIIVVTRQHLPVRRNPRPHEEDYTTCMSTFEGSIHSASASRTRLLPFVVLFQLQGLVWNNYLHPATALKMLEVMDRVAKDCKGSNMRLPFTADSMKTLFQKIPYPCPGTDSRDLSPEHLVASLVETEEVRREEDPTRTAPYGPSLPDSQTWVLKAIVTPTRIMLHGPDAENKNRVLRMFPRHSDYFLRVIFCDEDGQDLAMSFNVINSAIFDRYRKIFKDGIQAAGRKYEFLGFSHSSLRSHSAWFCAPFGDNLQQHNNGSIIKSLGDFSEIRIAAKCAARIGQAFSETPYAVDILKCDIGIKYIPDIKTEDGSRVFSDGCGTISWDALEEIWDHLPMTSAPTCLQVRLAGIKGMLSLDSRLKGKVICIRKESMMKFPSNDQTMLGICDTASKPLRLVLNRQTIKILEDMGTNAEWFMDQQNKALDVLRKVTATAANTSTFLEYQLVGTTVGLPKLIKYLSKIGVDYRRDNFMKTVVDHTILQELRLLKHKARIPVDQGVTLFGIMDETGFLEEGEVYVTFDDQYDKLQGRVKRSLKDGFVLVTRSPALHPGDIQSAQMRTPPPGHPLRDLKNCVVFSQKGTRDLPSQLSGGDLDGDLYSIFWDPYVVPKQVYPAASYPRVSPTSLDRAVTPDDIADFFVNFMEADILGIIANRHQVYADFRDEGTLHRDCIELAGLHSTAVDYSKTGIPVSLQNLPKPPRMRPDFLAPAPPTHLFDRDEVDYIGDPDSDEDDEDGLGIRKQNYYRSIKILGKLYRGVDEKKIWRQDVQRPIDKSGPSLWDILHKHVRAALGEEGYAPSDIDYTRRLDEAWKLRELYEGDVINNMYQFSDSPRAPIKEVEAFCGSILNPRGSQTRRQRESSIKLKEEMDRVMSFFVKQMREHAGRSEREMMHAVELCWACVIVGNEALHGRSYTGDLKPLESFRVVAASCLVKELNELLTRKRLGRTGGYVGVRSGPQFHGALPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS87</accession>
    <name>A0A2T4BS87_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1395170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS87"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB72173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="543" mass="60046" checksum="BADA92A11FEF848B" modified="2018-07-18" version="1">MTVLTSPFASYNVANKLYKATLLNTVCLVAGLSIFFFGYDQGLMGGVNTTRDYAERMGFGHWDEDQNIVVVDKPLLQGGIVAVYYLPGTLCGCLLGGWLGDRYGRIKTIALACAWSICAAALQASAMNANWMFCARVLNGVGTGILNAITPVWATETAAHTSRGQFVSIEFTLNILGVVVAYWLEFGTSKYHDNTSSFIWRFPVAFQILPLILLFVIIWIMPESPRWLVKVGREEEARFILGRLRGNEGEDGLKAEAEYNDIINIHQLEVKTAKQQSYLSMLFGIGSGKLHTGRRVQLVIWLQILQEWIGIAGITIYGPEIFTIAGISAKDRLWVSGINNITYMFATLICVFTIDRIGRRWTLYWGAVGQGICMLVAGGLARATINAEGKASQSHIGGAATFFVFLYTAIFGATWLTVPWLYPAEIFPLQVRAKGNAWGVVGWSIGNGWCVLLLPTIFKALNEKTLYIFGAVNALSIVVVWALYPESNQRTLEEMDLVFASDSIWAWEAERNFAKLKAENPDLVQGSTNHGVVDIEQVAEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSN2</accession>
    <name>A0A2T4BSN2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_22579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSN2"/>
    <dbReference type="STRING" id="983965.A0A2T4BSN2"/>
    <dbReference type="OrthoDB" id="2942798at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="235" mass="27364" checksum="103AA41345088838" modified="2018-07-18" version="1">MSTSLPGLHISRKIPWNEPVETVQFRFRSRHITAVGQAADNYHPNVRRLKIQPTLLDQVIKAILYLFPKFAQAYMRRWFPEWYLPSAIVLKSQKPDWEEEFDNELANYRSLQPLQGAVIPRHFGVVQFDGVRSHLMADVGGVCIPYTTETAEEAYAYIRKRLHESLMALASRGFVQDDVKLDNFHVVGNRVVVVDLERVERGRSPDEMAKFVESSVQILMQQYRNYLENLRARYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSQ3</accession>
    <name>A0A2T4BSQ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_22573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSQ3"/>
    <dbReference type="STRING" id="983965.A0A2T4BSQ3"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="349" mass="37630" checksum="9CC43A4155166F18" modified="2018-07-18" version="1">MLSLSVLAAVNLARPTSTKRHHQPASSSLVSPTDRIESLRIIAITLAIAVLCIHQSYLSIQLPSTTAALPSYTNLPAVTASTRPSNTSSHSLSILASTPRTLRRAPQQNTHQPLLPVSTALLLPPPKMSRPAPRKPRHHRHPSNRIPAISDYESDAAAMAPAYSAPPPRTNTELNLSVLQRYLPSISRILSIAANAVVYTFDAAAQSWEKSGIEGTMFVCAQTPLPDDVHNRPRACVFVLSRRGLDNVIVDLARVGHVEIMGELVILKVESDHEAEEKVLGLWIHNDEAETRATNGAIIEESWKIARAAGTVENEGLEAGPEAGPAMQAIGRPLTLNELFGRQAEATGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTE5</accession>
    <name>A0A2T4BTE5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1341893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTE5"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="242" mass="27420" checksum="781A00916D76E2B6" modified="2018-07-18" version="1">MPHKHRTKKGGDGADFDLPPTENARPLPVHKRNATTTSEGRITKKRHRKSTRDNDTPRAFRRLMAVAGGKKLRSGLDDGQAEKPSTKGTAQKSEDLQIRPGENLGAFASRVDAALPVSGLARKTSVTKDGKDAQGFKVYRTRKERKMHKLYDQWRAEELKIQEKKEEELERIAERDLEDDAAGILTSAAFQDESSRTRRKKGHKRRKVAEEDPWLELKKRRAETKPKIYDTVLAPPEFSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTX6</accession>
    <name>A0A2T4BTX6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1341076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTX6"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="327" mass="36345" checksum="31EF8CFBD9FDDD47" modified="2018-07-18" version="1">MYEDGPNPTKVQITPAYKRANPPPPLVLIHDGGGTTFGYFMLGNLYREVWAIHNPHFFDGGAFEGGMDEMARLYIQYMKDAGIKGNILLGGWSLGGFLSLAVARFLAEDPEATIKVLGIVMMDTPHHLPWSQVDGPTDDPVIENIPPAIQKCFERCDEMIEHWEVPRWDGPACDGKPVFFGVGGRRYSVPPGKVLYKPFEGAWSPVEVPRYDKPAEEASQSEKGSITPPPTVLIRAIQSMPLPEGRTEPYIIDKHRNDRTLGWSANAPEFIKAVIDVNSNHYEMFEKTNAAQIKDMTTQLNLALEILDSIGNSVNPSFGGKPKLDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV79</accession>
    <name>A0A2T4BV79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1340336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV79"/>
    <dbReference type="STRING" id="983965.A0A2T4BV79"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="108" mass="12216" checksum="D3814426894BD64D" modified="2018-07-18" version="1" fragment="single">QGSGSRVLPGKKMPGRMGNEFRTVQNLKVLKVDNELGVVLVSGPIPGPKGRIVRLQDAKKRKAPALQHREKARGELEQRQPDLQDRLEQARLRHLDMQAQRRAHMAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVF6</accession>
    <name>A0A2T4BVF6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1340459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVF6"/>
    <dbReference type="OrthoDB" id="10539103at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="64" mass="6899" checksum="B90797326F936FC4" modified="2018-07-18" version="1" fragment="single">SGRFDLGCPQSNATSMSSWVFVRISSAGCRVTSVQAAYCACQTKKRVECSLSNDDGRLMVTPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW10</accession>
    <name>A0A2T4BW10_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1394026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW10"/>
    <dbReference type="STRING" id="983965.A0A2T4BW10"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="497" mass="53443" checksum="02F104A385B2A396" modified="2018-07-18" version="1">MSGPPPLHGDLFGFGNINVLPMFQGAAHSQGFSGPTSSATGIADALHLDDSSTDAMALLESTMMAHFGADMALNIDPMTAVLDDDGGDLDGHLLSPDAMLKPQDQFNSVANDVPGAGPLPAAAFTPTAMAGSSSSSSGNNNPLTEFTKRRNWPAKVVEELRDLLQILDSNGRIKYVSPSITALAGYTPEEVQDTFLKQLIHPDDQGVLVSELHESIATGNPLRMFYRMKKKDGTYAIFEAVGHAHIAAARFAPNPNNQSPFCQAVFMMARLYPTKNAALLDSFLEHKIENERLRRRIAELRREEEAEAEEAQRLWAHNREGRSEVGTSENASTAASTVYGYSGRPTEITLPSAAAAAAVDGALTRKNLEGATGGNRQDSLREKMARFEASSADTIAFLTGIENGERMSSGNRSPTLIKGDAGIAMPMDRDSKSGEKKKKLKLAEEYVCTDCGTLDSPEWRKGPSGPKTLCNACGLRWAKKEKKRNSVGTPLTKPMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW39</accession>
    <name>A0A2T4BW39_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1472190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW39"/>
    <dbReference type="STRING" id="983965.A0A2T4BW39"/>
    <dbReference type="OrthoDB" id="5353066at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="813" mass="89474" checksum="C1DE4F08C817BB0D" modified="2018-07-18" version="1">MPHFDKPTHGWNPPVKITLPIAYEQYKARNQAVEDPFAACARNAIPPPGVSPYDDNVAQQTYASDHPSLTKWSMGRNLTHPKSLKLDRDEVRSDWETIVGDDEGDSRLTSPPAPQVTLKSLGIIPNNPESILADGNGNDINEDKATCNNAIDPKGKGREPAFPRPGTPFDAFGFSNTPEVLEPHSQVMDIEASYTPSPAYCGHTGFVRQPVHGGLDGGLSRPKASKASSDESADLFKYDGEAYSTFLHRSTTRDIAKRHPAASFEDDRLFVQKTRIGEEDKMQSKSAFYNPTAVRVPVGRGQQTLYEPSTEQSPEPAVEEEEEEEEECWPRVGGNDAAAEADWQTVTTGPVCKGLNTSELNLIKDTGSSLADVSDIVEEEPTPAEHRRAAGTISHQRNQSIHRPKGYYAEDFAQTATRMNNNHAASADYRPQKFLDDSARLAAPRVVNPFQTPPSWKSTGRVIDLDDSPENCTCKGKGKAVDTNVGIPTRADAPPLNRTESTETVWPQVPRRDETVNDFDQAFCETRIGDETLPSDDSANVFSRLPFSLIDLKEAAKTHGSQRYRGTVEANTFAQRARLGPLWSGSTDAGPSTEAGPSSGAYRLGGSDNPPLERPSTAVFRDQITRGRPTHEFDGIEDSTPSPSSAILGSLRSKVNLGFAKKKEKEKSTYSLDPFKAAAALGAKCLRIKAPVKKKDQWPTARNQTGGVLTPSEAELIESARGEIMDRRRSPEKLEKKRTFLFILIMASSIVFPFIGFIALIRKFDSSVAWFTYGEIKDFTKEQRGMLLQQLLVEIFVYSIVIICVALRTSHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWU7</accession>
    <name>A0A2T4BWU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1404001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWU7"/>
    <dbReference type="STRING" id="983965.A0A2T4BWU7"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF42">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="279" mass="31223" checksum="B9552765098919D8" modified="2018-07-18" version="1">MAPLETTSFPPIRACIFDMDGLLINSEDIITQAINQLLEKYSRPPFIRSIRAQLMGIPDATNSDVFHDWAKLPVSREQFALESREQMHKAFPNCEPMPGAEKILSNLSRARSASLGKPIELALASSTRTHSYQLKMSRPETKRLLDFFHPDKRILGDNPRVPKGRVKPAPDIYLLALESLNSAIGPDETPILPSECLVFEDSIIGVEAGRRAGMRVVWVPHPDLAAEYQEREKLVLAGRTGLIEIGDEWQLGEVDDGWAECITSLEHFDYGKYGIELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX07</accession>
    <name>A0A2T4BX07_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1403994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX07"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="88" mass="10089" checksum="A0746BFCF1AF831E" modified="2018-07-18" version="1">MQPHGRNLWAAHFCNVLGKASLSLIWHAYSLSVLQGFTVSLSSRWDVLHDLRLGLSSLFPRSQRSKKTPRVRGEDVERKTEWLDGFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX79</accession>
    <name>A0A2T4BX79_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1471950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX79"/>
    <dbReference type="STRING" id="983965.A0A2T4BX79"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31481" checksum="4FBAB14DAE4D512A" modified="2018-07-18" version="1">MKAQRDRDDSSVEESDPFLGASLHSKEESRSQRRRDILLYSLTLLLGISLGSHVLTYLHIHRASYLDAVCVRHTQQNPTPIDIPIHYHSVLYDGTFLANSTSVYRLPPSPEVDAAWEGLGTTSKTLLLTRPQAIRAGISPDHLKTPSGEFPVLFEFNHHLHCLNMVRKAVFFNYEYYSSPDSPERHLGKDDETIGKHVTHCIDMLRQVLQCKPDLGVFGQYWVKDPAQGVDGSFVDFNTNHKCIDWEPVREWVQAHQTLDDLVVELQDGDRILDIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXA9</accession>
    <name>A0A2T4BXA9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXA9"/>
    <dbReference type="OrthoDB" id="4890287at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="572" mass="60778" checksum="CDF74F05C37DA09C" modified="2018-07-18" version="1">MCDVLALYVLKNGWAAWALDLASKSLRGKPVEKGQVSGGYKRSRPIEDDAGPIAHWCSCGNRKLESSGQAQSLSIEVAIGALKKQSKQLKAPAKQQHQKPTTLTRQAGVTKKQAKTQKKLAAPVPTRQLRSSAKQLEASNNAPAAAPDAAPKSEDVVRARVPTTEQIDLAYERGMWAGATPEIFADALWLAGPGRRQIEKESGKASQEMAKGARGSVETVVLHYFFLNNHINTLTDGLEVTVLGAYLAALDHGNVRDSDFTAYAGDVARHASLARWTVATMELVVQWPTILDWHAGCLSTLGLVRGLTLRAWVYASHWDVLMHYELGSSTDWEEHVPSWLYIASALGHDAGDLCSDTRMGCADNAYFAVGSTAGYEGVAACMDIVCDALEAVVLRDTRGAIDIGCVAGSACATFERTGGDLCACSGSGSGSSSSSNSSRGAAASGSCESSSVLASICGDRRITAEDAASLVGIRDGIRARSRELPRHRGSRDMAHLSHADREVVYGHCMHAMATGGSGAKQAHARLQVAYASAAQSLCGQLRRSAAELRQRIGEDALNLSSDCMCGGECSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXD2</accession>
    <name>A0A2T4BXD2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1404197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXD2"/>
    <dbReference type="STRING" id="983965.A0A2T4BXD2"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015438773" evidence="2">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="4">
        <location>
            <begin position="65"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="3">
        <location>
            <begin position="179"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="331" mass="34815" checksum="3C8629B8B6D0667F" modified="2018-07-18" version="1">MLSSLLAFGLAVATAEAVVARTSGCQLHLSASGAISGPVGEISSGQVRAGGGVSSTRFTLQESQLLDDKGRGCWWTPPAHVLQCDKNQTPDDGFEVACDGAVSYHGQTEFWECQAGEQGQYNVYLEDGHGVNCNKITLKADSCRSECPTSTSAPTPAPTPAPTPTPAKSCPANLEGAYEFPHLIIPVDEADPDRAPGTSYFGEVSSTVSSLFNFDIPEGDRGKKCSLVFLFPEQKDLETSSFTFSGSGALDFALLDGPATQGTTWNNRPGVKEDFGITTVAPGHGYVISTFDCPAGEAVAYGISAAEGGGSEVWWFEDYNPAPIGLYITKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXG5</accession>
    <name>A0A2T4BXG5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M440DRAFT_1393842</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXG5"/>
    <dbReference type="STRING" id="983965.A0A2T4BXG5"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <ligand>
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    <sequence length="1227" mass="136168" checksum="A10BD79892FC9373" modified="2018-07-18" version="1">MGISRRPKDKAARNAQAAGGGSSEKPKKATYEVTKKKEIGVSDLTLLSKVSNEAINENLKKRFEGAEIYTYIGHVLVSVNPFRDLGIYTDQVLESYKGKNRLEMPPHVFAIAESAYYNMKAYNDNQCVIISGESGAGKTEAAKRIMQYIASVSGEQSGDIKKIKEMVLATNPLLESFGNAKTLRNNNSSRFGKYLQLYFNSTGEPVGADITNYLLEKTRVVGQITNERNFHIFYQFTKAAPSQYREMFGIQKPETYLYTSRSKCFEVDGIDDVAEFQDTLNAMKVIGLSQAEQDEIFRMLAAILWIGNIRFQEDQSGYAEVVDKSVVDFVAYLLQCTPEEVIKGITIRILTPRNGEVIESPANPAQAMATRDALAKAIYSNLFDWIVERINISLKSRQATSNTIGILDIYGFEIFENNSFEQLCINYVNEKLQQIFIQLTLKAEQEEYAREKIQWTPIKYFDNKVVCDLIEQIRPPGIFSAMKDATKTAHADPAACDRTFMQSINGMSHAHLIPRQGSFIIKHYAGDVTYTVDGITDKNKDQLLKGLLNLFQSSGNAFIHTLFPNQVDQDNRKQPPSAGDRIRTSANLLVDTLMKCQPSYIRTIKPNENKSPTEYNSPNVLHQIKYLGLQENVRIRRAGFAYRQAFDKFVDRFFLLSPATSYAGEYTWQGSYEDAVKQILKDTSIPKEEWQMGVTKAFIKSPETLFALEHMRDRYWHNMATRIQRMWRAYLAYRAESATRIQRFWRKKRTGAEYLQLRDQGHKVLQGRKERRRMSLLGSRRFLGDYLGINASNGPGAPLRQAANLGSNERAIFSCRGEILEAKFGRSSKPSPRIIVVTNSKFYIIAQLLVNGQPQIQVEKAIPLGSIKFIGTSTAQDDWFSLGIGSPQEADPLMNCVFKTELFTQLQRAMPGGFNLKIGETIEYAKKPGKMQQVKVLKDSQQRADYYKSGAIHTQPGEPPNSVSKPMPKAKPVPPRPITRGKLIKPGGPGGRPSRITASRNTQPRPTATGTRSVPPPPAALGNIVSASSNAGPSASTSTLSSSAHQIPVVGNANKPVNSHARNQSGSARAPPPPPAPPAPPAAKPKIMAKVLYDFAGQKENELTIKAGDMLEIIQKENNGWWLAKNAQGQAWVPAAYVEEQAAPAPRAPPAPPSAKAKPVPPTKRPVPGGRKPADLAQRDSGMSLNGTGGDSRSSTPTPSLGGSLADALLARKNAMNQKRDDETDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY10</accession>
    <name>A0A2T4BY10_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1338008</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="PTB74164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
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    </dbReference>
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        <property type="entry name" value="MITOCARRIER"/>
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        <property type="match status" value="4"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
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            <end position="164"/>
        </location>
    </feature>
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            <begin position="295"/>
            <end position="400"/>
        </location>
    </feature>
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            <begin position="413"/>
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        </location>
    </feature>
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        <location>
            <begin position="520"/>
            <end position="609"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="263"/>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB74164.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="613" mass="66475" checksum="3E273EDA3C3B3E55" modified="2018-07-18" version="1">MTPSSPATEVQKAGGPRELEQRQKNPDRVESLWAQLGPNANGELDLKGLQKGFRKIDHPLKNADALLKKIMTEVDTNRDGKIQYEEFRVFVRKAEGQLFDLFQSIDRDGNGKLDKAELQTAFKAAGLTVSNRRLHNFFSDMDQNNDGYVTFDEWRDFLLFMPGNQDASHLHAVLSFYYSVVNVTPEGDSLVSGETLEGLGRAGSSSSFLQILFGSLLRVAFPSSYPKPPQELPLPPPPPSPAQVAGTQGPSGAGENAATDAVAHSDGDGTSVGHREESSTGATPTLKKYKLTDFAPHPGYFLAGAIAGGVSRTATAPLDRLKVYLLVNTNSGTETAVGALKKGRIIDALRNASRPFSEAVKDLYRSGGLLSFFAGNGLNVVKIMPETAIKFGSYEAAKRALANFEGHGDPKNINSYSKFIAGGLAGMIAQFCVYPLDTLKFRLQCETVKDGLKGSALVRQTAVKMYADGGLRACYRGVTMGLIGMFPYSAIDMGMFEFLKKTYRIRYAKYAGCHEDDAQPGNIATGFIGATSGAFGASVVYPLNVVRTRLQTQGTAMHPQTYTGIWDVTRKTIQHEGVRGLYKGLTPNLLKVAPALSITWVVYENAKRLLALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYA8</accession>
    <name>A0A2T4BYA8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1337664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYA8"/>
    <dbReference type="STRING" id="983965.A0A2T4BYA8"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="503" mass="53941" checksum="80B4DB383CF8A29A" modified="2018-07-18" version="1">MESLSDTKWDVVISGTGLQQSLLALALSRSGKNILHVDPNEYYGEAEAVLSLQEIDEWAARRQFGDGGGVFASAKVTRSDGAEESLSPRGYSLALAPQLIHTRSELLSKLVSSKAFRQLEFLAVGSFYILQLSSTGSSTPSLSRIPSTREDVFANTTISVKAKRGLMKFLKFVLDYTSEPQTDVWKPHAGDSLASFLAAEFKLDADLQAYIITLTLSLDGKITTEAGLAAIHRHISSMGVFGPGFAAVYPKWGGLSEIAQVGCRAGAVGGAVYMLGVGIKDVQKAASTAEMPEALDIVLSNDMPIKSKTLVKGLGKPARESRRLSRLTAIVDSELSSLFEAVSEGPTPAVAVVAIPAGTRLGEDGVSEYPIYAMAHSSETGECPRRQCVLYLSTPAGPHAQAHLEKALSSLLASLAAEGQEPPKSLYQLYYEQTGYDTPSVDVDGQSAVFSLLPLDLAFNDSVLDPVRKAWEMVMPDVTEEEAAEYMVFTDREGADAEDELDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYD6</accession>
    <name>A0A2T4BYD6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_21105</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYD6"/>
    <dbReference type="STRING" id="983965.A0A2T4BYD6"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB74328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="254" mass="27853" checksum="0B2DB31BA411DB59" modified="2018-07-18" version="1">MAPKKKIAVMTSGGDSPGMNAVVRAVVRMSIHMGCDAYCVYEGYEGLVQGGDFIRQMAWDDVRSFLSEGGTLIGTARCMAFYERPGRLTAAKNMVLNGIDALIICGGDGSLTGADNIIREEAHDRFESRESIPGHVQQGGVPSPMDRCRAVRLAIKCMQHLEGFGRNAHNRVKKDPYSTSVIGIQGSEVVFSPIEELEEKHTDWANRRPKTAHWLDMQDVVNVLGGRPAYPKPEKSLTGLIAKDTKRGLYWGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYP7</accession>
    <name>A0A2T4BYP7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1045271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYP7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="122" mass="13524" checksum="740B624C2426E26D" modified="2018-07-18" version="1">MERKKKKRGRCWLCRGRAGRLSHYLARSRCCSGLLVGAVAARLGSGQGWRLDSRSFLCSFPWVVFCFSLSLSTNLRHAIFCNTVAFVVLRISPSLAILCSPICCESAAFASNRRGRGQSLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYV3</accession>
    <name>A0A2T4BYV3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1360380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYV3"/>
    <dbReference type="STRING" id="983965.A0A2T4BYV3"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="198"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="392" mass="44803" checksum="4772EC5324577251" modified="2018-07-18" version="1">MASASSAGRLCMLACRRALRVPRMPRTQPIAWHAPGTATTGRAFGTSSRRLADEKAGQDDDGDGEAYKTLDLKMLNKAFLDGVTPESLRQLDELAKNNGYTTVEEYLEATMRQTPGWASEDRALEEDLYKDDVGEKPNKSSFWFDEDDPETNTEEHDEFDEDDITSMAHGKLDEIRDMRHYDRLAVWEMPLLAKFAKPFVPPTEKQVLRWRYTTYMGESHPAEKKVVVQFAPDDLELDDVQREKLKKLAGPRYNPETELIKMSCESFEHQAQNKQYLINLVNDLIAAAKDPKDTFQDVPLDLRHHKIEPKPQFPKEWRLTEERKRELAEYRQKAALADAKRAEEGLLVDGQKLIDEFLIQKLAEQQEKERVALLEAVPRATKATGGGARARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYX0</accession>
    <name>A0A2T4BYX0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1440000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYX0"/>
    <dbReference type="STRING" id="983965.A0A2T4BYX0"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="134"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="388" mass="39994" checksum="1611F0D6ED9CE31D" modified="2018-07-18" version="1">MGLVTNPFAKNIIPNRYIVVYNNSFGEEAISAKQAQFAAKIAKRNLGKRGLFGNELSTAIHSFSMHTWRAMALDADDIMIKDIFDAEEVAYIEADTKVEHAALVAQTNATPGLIRLSNQAVGGQNYIFDNSAGSNITAYVVDTGIRITHSEFEGRATFGANFVNDVDTDENGHGSHVAGTIGGATFGVAKNVQLVAVKVLDADGSGSNSGVLNGMQFVVNDVKAKNRSGKAVMNMSLGGSFSTAVNNAITALTNAGIVPVVAAGNENQDTANTSPGSAPQAITVGAIDATTDIRAGFSNFGTGVDIYAPGVDVLSAGIKSDIDTAVLSGTSMASPHVAGLAAYLMALEGVSNVDDVSNLIKNLAAKTGASVKQNIAGTTSLIANNGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ74</accession>
    <name>A0A2T4BZ74_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1380047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ74"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ74"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="270" mass="30835" checksum="AF5D2C0556F714CF" modified="2018-07-18" version="1">MPSKTSRLTPIKALLFDVFGTLVDWRSSVTDELSLRIFRKQSSPEANLPPALLTRLEALTQSDWDRFVQEWRDSYTAFTRNFNPQTDEWKSIDEHHRDSLVELLRKWDLEGLFTEAEIESLSLVWHRLTPWPDTAQGLEELHRRYTTATLSNGNTSLLRDLADFGGLSFDHVFSAETFRAYKPDPGTYLGAVRALGLRPEEVALVAAHLKDLKAARECGLGTIYVEREGEEEWGREEERFAEARGWVDLWVGEGEGGLLGVAERLRALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZW7</accession>
    <name>A0A2T4BZW7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_364226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZW7"/>
    <dbReference type="STRING" id="983965.A0A2T4BZW7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="288" mass="31375" checksum="5DCF281FBEBD845C" modified="2018-07-18" version="1">MRPVLITGVSPNGLGAATAHALAKYDPASLIFTARTTSKASAVANTIRADYPNLKTQIHIVRIDLSDLESTRQAAATIRELTPIIGIMINNAAVMALPERELTRSGLEAHLATNFLGHFVLTTLLLPWLKAAGPKARVVNIVSGGFYVQPFRFSDYNFDGGKELPEDERVDLDMAERFGMGWVKDAGTGYVPFLAYSQTSTALMLFTKGLNEGFSGEKIKAFSAAPGGENGGEWLDMVIMLLLTSLVVLTELQRHIDDCQIKQTPQHVRDDAAARKLWALAQSWMEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C008</accession>
    <name>A0A2T4C008_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1037982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C008"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="99" mass="11483" checksum="EED68C356A5B0F3A" modified="2018-07-18" version="1">MCCSDRFEYLQVQYRALLASHHHHHQNHPLQTMPGARHQCRPDSLQSAPTVPIAVTHPEKSQQFEASVREIRLQIVQPRPSSTPFSRHIKRHAAKRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0F0</accession>
    <name>A0A2T4C0F0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0F0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="207" mass="22134" checksum="5D86D47DC43B7D10" modified="2018-07-18" version="1">MEALACRIPPEATNGQDDSDLNGHHSESAVELRLSLVLRKQADSSAVDMEPSLPSARTTAVAQGPFIKNGAFGDSSESRRAIETRMHPDDFVTLHDSVPAILGSFSSLSSPQLSSSDASNADAGFLFARSPMTDEKRLTLGAALACRPSRSPAIRWDLDDEPRARVAVCRQCNMESNKLGLQLGEKDDATLLMPVLAGGELDGQRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Y8</accession>
    <name>A0A2T4C0Y8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1439796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Y8"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Y8"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="335"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="547" mass="61694" checksum="124211DE0CD389A5" modified="2018-07-18" version="1">MLHLSLSGAAPTSIRLRGKTIHSALGEPTQFVDWEFKAEERLALEDLEKLLNAHDGASTGPKVRECEWPTVFDFMFQAQTRYKDDGHATRRDAALFGLNLTSEILQLMPEDWGLGVFRGGMLLLLKVVKRDLAIKTRILDIFQDISWKMTTITMAFERLGAAKEGLQRQRLLGKEKYTADTILERWKASMSELAEHMERSKLTSMSDIKSNTSLLPGMQSSIDASKQAVGQLGDQMAELPQVMQRTVHGLFDKLAETGLIEENRRLRELSRSPQPGWHYAEDTNPDARNITPAITQMELIGALGVRVYAHMKVLEDVLQQTSDFDVPSLRQVRGLAQHREFDHWFKAESSSLLFVECLLQDCSPTVTAASVFTSSLLCTLSSQRDAIPIPLFFFARLDSGTSDAGGPAYMMRSLVFQLLMSAAQPYLDLGFISLDLFEACAQQYLPALCELFVELVCQVPPCTKVYCVLEGLDLYETRECRQGVQVDYIADMFEVLTARLEAEERGMLNVLVMIPDRSQGLYKRMWRRESPWSCIELMDEMGFADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C124</accession>
    <name>A0A2T4C124_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1335682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C124"/>
    <dbReference type="STRING" id="983965.A0A2T4C124"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40070" checksum="153EA98B2D8AE638" modified="2018-07-18" version="1">MEHENVDAKLRSRLALRSAVGEVRQNLKDARKARKEDWELGPLAPKRDLGFNDYGAFKENVRQDWSNYGLHQPNPKVVEQRCAWAGGVKQLNLAPGDRVVIRDGPDKGKIDRIRSVQPQVGTVTLENRHQAVVQGMFGNPSRPQPMPISIASIRLVYPITNPETGVTRDVVINQLKAVPPNMQSPNMSLDRWRYGKKWDRLVPGLNVVIPWPAVEVPEFETMEADTIREHVEDRTFYYGLLSPPMPEQVVDELRNKYSKFRTRHEEWYIQKKQAEEALKKGRQEALKAMQTPLDEFHEKNRAARAEAGEPELSEEMLAKIGEFMAKKKSAALENAGASEVSTAPAPPQETTNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1R8</accession>
    <name>A0A2T4C1R8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1431921</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1R8"/>
    <dbReference type="STRING" id="983965.A0A2T4C1R8"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="64"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB75454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="38626" checksum="8D6D2EC000EF2AD3" modified="2018-07-18" version="1">MSNSPTPASRPGAPWRLASVAVMGSVGAASRAFLYGLNKVEVTGLDNLLGVLDRRKSGKRERGLLTVCNHVSVLDDPLIWGILPLRYAVDPENLRWGLGAHDICFKNRFFSTFFNYGQVLPTHRLWHSPHGGLYQPTISQAIKLLSAPSSVIKPSDMTFTTTGSDSFVSPSAFAANHYAWVHIFPEACCHQNPENTLRYFKWGVSRLILESDPAPEFVPMFIHGTQNIMPEDRGFPRFLPRIGQRIRIMIGKPTDADSLFGQYRSAWKRLVEKSGDPDLLKNDPEAMQLRVDVAKAVRDEIQKLRLSMGFAPEEDETAALAETWSKEPNKRKFKSPVDGSLVNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C222</accession>
    <name>A0A2T4C222_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1378092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C222"/>
    <dbReference type="OrthoDB" id="4430588at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27953" checksum="7EAE00717F1CF73C" modified="2018-07-18" version="1">MRRGAMFRQTPGQLEWLFPQEEFAGILPKRQAWPANTDLVPTNFVVPQEVLSREPGRATDAETGILSLPTELLVQVFRSGTDEDAICLALTCKALLFASTLAVKHRPTLPPSNRTSFHHFQTATRFDAGAHCSRRTMIDFLLRLHPLGPGRRASPTVSLCQDCLRYRPVDPSWWTDKGAPCPERSPAMASGWELAVEHWRWRRMLQCPECWASSHEAVGGFEAGEVSPAWPAGRGTLESLSNTRPLFGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C295</accession>
    <name>A0A2T4C295_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_66393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C295"/>
    <dbReference type="STRING" id="983965.A0A2T4C295"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000006">
        <property type="term" value="F:high-affinity zinc transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="380" mass="41578" checksum="7753757A1D7861DE" modified="2018-07-18" version="1">MAPTKVTSVDLDTADPRDIICYLNAGENEYNGHLGVRISALFVVLVTSTLTTFFPVLATRVRRLRIPLYVYLFARYFGAGVIIATAFIHLLEPAYEEIGPNSCVGMTGGWAEYTWPPAIAMASAMIIFLLDFLAEYYVDKKYRMAHVQVEGAITTGGHGHDHHGLHSADQDGAIPPNRKTAERVPDAATSDKGTPSNDTFDVEELKNIEGDNQQAAIGFQSQIAAFLILEFGVLFHSVIIGLNLGVVGDEFKTLYPVIVFHQAFEGLGIGARLSVIPFPKHLRWMPWALCLAYGLTTPLAIAIGLGVRTTYNSGSFTANVVSGVLDATSAGILLYTGFVEMLARDFLFNPYRTQDKKRLTFMLISLYLGCAIMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2A1</accession>
    <name>A0A2T4C2A1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin depolymerizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1439381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2A1"/>
    <dbReference type="STRING" id="983965.A0A2T4C2A1"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="101"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="258" mass="28277" checksum="A45C7E19FD36FA73" modified="2018-07-18" version="1">MQSGISASEELQKAFSSLQATPSDFALLVTIQRESLVPVETLAGKSSDFGENLSVLEPFVKPDAALYAILRRNRRSPCMQCRAEQEAGSGTAIREIHLSQSLKMPVNEDAIAAMKEVAEGTKAAATLKINAATERVELAPESPNPSSLTELIKGISTVEPRFTFYRFTHTHNGEEQTPILFFYTCPATAGNKAIKNRMLYPLMKKAVLTIAEQEAGISPEKKFEVEDPSEITEQDVLNDLHPKPVTSSGFSRPKRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2C9</accession>
    <name>A0A2T4C2C9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2C9"/>
    <dbReference type="OrthoDB" id="4987761at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="89" mass="9665" checksum="6F9608AE6DFD6D4B" modified="2018-07-18" version="1">MGNNLSSTFEPDLSKVALSPSDRGADIILGVIWLLVIYALVMVWTTCALVDRWKGPQDRIRVGGGRVMMAVVMSAAWPAVVVYLAMARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2U8</accession>
    <name>A0A2T4C2U8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1357369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2U8"/>
    <dbReference type="STRING" id="983965.A0A2T4C2U8"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015697590" evidence="8">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="89"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="416" mass="45607" checksum="05BEC83FE15223D9" modified="2018-07-18" version="1">MWHRFILLLFLTPLWTSLVNAVPFSDTPPHGFSLAVTRKSDASRSFVRDWAAAHHKWGNGVPEEVAAKLSLTDTLGRVDVVPMGSDDIYLADVQIGNPPQTVKLALDTGSSDLWLQSTDTEYLYNVKGPWAPLYHPNESTTSHLIQDAEWSVMYMDGTHAGGIVYHDTVQLGSFKVENATVQSATAVTSRFEEEIELSGILGLAKRLPNTVEPPQPSFLSLLRQQLKHQVIGVDVNRNASGVFTFGYLDEGRAAEDIAWVDTDPDSPHWDVAFNLTTWGAQTTPWYSQPFVATIDTGTTLMFLPDNLASGYWLGVPGAKVDRQLSGAYSFPCELAGELPDLMLKIPGADRILTVPGSYLNYGPSELDPSACWGGMQSADGLKVTVLGDIMLKALYVAFDLDKGRVGFAKKDLHDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2X3</accession>
    <name>A0A2T4C2X3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2X3"/>
    <dbReference type="STRING" id="983965.A0A2T4C2X3"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="125"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="539" mass="60140" checksum="821FFE02EF62D45D" modified="2018-07-18" version="1">MERSINFMCGWCEILHEEVTHYYHLTKSERDGQGAITKEAGDPPADARFSITIRFGKHNSTGSPLCLKISIGTYTLALQCIRDCGSNHARCQSPTREPLPTRIIDCIDPARPRLFITQTAPPDYYVALSYVWGEEQPHRTTKARLSSYTKRIDTECIPETIRDAIKATRSLGLRYLWVDAFCIIQDSSEDKATEISRIRSIFRTAHVTIIAANAERVSKGFLNPRVLYNSPCELPFRCPGGSIGTMFVQPFEQGPKEPVNTRAWCLEERALSARALWYCTHTLQYECQMGHKNVGSSQNMADDRDGFPRLPDRIFTPALPSLPQISAAEAEEEVSKAWRNILVLYSKRTLTESRDLLIALSGVVGYFADFWSNSRYLAGLWEHQLPCCLLWSIGSAAAQRPAKYRAPSWSWAAVDGSITRAVNVYGEVVSGVLVLDVIIRLVVWDPINGEMFEVAGGPGGMPDDSRSERAEIGYVQRDAVEEVSVAKGEVYAAIIAPGTTSILGVVLVPVVTDNVGWFTAPFVDRDVWLNTPRERVQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Y7</accession>
    <name>A0A2T4C2Y7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Y7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2Y7"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="265" mass="29597" checksum="27644264E9A751F2" modified="2018-07-18" version="1">MTTVSLSRHDINVLEKIKDPESNPAAGVVIDPALPRDPQIVDHSVYERVVERERAIIRTLQAIEMQLSGFQTEEDTDKSVESYKSCVSDFSNLISDYPLYASARNNRAQIMRRLYGDAMLLSYTATMPMPLLPEPEQSERRAAAKQTLEDMETAIRLLTPPSPSSPMSSQAARTLSMAHTQRAAIYLRTAKLMSDRQLDIDESREEATWSRIDFEEAASRDLALGGRYGNQIAKALAVSVNPTAKLCGQIVREAMKKEYGPAFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C331</accession>
    <name>A0A2T4C331_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1402491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C331"/>
    <dbReference type="STRING" id="983965.A0A2T4C331"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="371" mass="42139" checksum="45DC1F4433E7CB7D" modified="2018-07-18" version="1">MGDSSTHPHRLSAANPPATGAEPMEPKVGAPRKPSIVVSEDPPNIEEQDPPLDANDSEDIDVEDDDDYYDATDGNSAESVTVRSSIWEHEYEGGRRYHHYRHGRYPLPNDDIEQEREYMKHVIHMQLTGGKLFNAPLAPNPQRILDLCTGTGLWPIEVARIFPSAEIVGLDLSPIQPLMVPPNVRFLIDDVEDEWMDRGGYDMIHLRHSCIYLKDVDKLIANCYAHLKDGGWLEITDYCSYLRCDDGTMPDDYPPAQVAMMMHRALRGYGMNAYVINELHDKYKAAGFKNIQCRVTKTPIGAWPRDPGQREIGILFRDIIHELVGALAAKPLKTLGWDDTELEVYLASARRALWDRKVHCYANFVSWWAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C348</accession>
    <name>A0A2T4C348_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_20175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C348"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="556"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="952" mass="102991" checksum="62054CB4BF374457" modified="2018-07-18" version="1">MPPRKRQRPNPAALSSQSSPTTALSPETSLSRASTASAQQANHQKKPPLSESNSEHKSSDASQRVKEIRKTNSWYASWSKSQKATPSTSVARENILGGTVKSRAAPDFSRFETKRSEDDASMPDDADSVSPPPTITNNTSNTQNADKTSEGNRSPAPSQNTDQGSSKVGRATAVSPAPEANSATEQQQKAADLKPSPEDNPESKASIEEAGEASDASRNQVASSGWFGWWYKAAPAEPPNDSAAKPQETKEEAVKAPEAIESAESAPPQEQAPPSETPAPDVVTEEAPQSTSWLGFWYSTPQPKTKSAPTKSEAVSEGPTSSKAEASSKQESQTIPGPSGEAARSNDEHSKASAAMVLRASSKKSTRNPDEEPRANTGDAPTKAVSQSEQVEAQSPPPKAGSTWAFWSRDSPKSKGKTTSPESGQIAVMGEGSEARPSPMAERRLSETTAKETTKDDAVPAEPPAGVLSWRRSKRTRPVSLNFDSQRPPSADSTKSAPLDRLSATPQTPQATTEQELPSSKSLTRTDSKKKKPVPAAKKATTESEVTVKEPPNLLLPSFASTYQMKENPSILRQITSLLLRTSQPPPNHVFRVKDPPKIHKAIAIGVHGFFPAAYLRPMIGQPTGTSLRFAGLCADAIRKWADNHGSPDCEIEKVALEGEGRINDRVANLWKLLLNWVEHIRQADLVIIACHSQGVPVSIMLLEKLIDLGVLENTKVGVCAMAGVALGPFPDYKSSILMGSVAELWEFGDPQSSNSQRFEACLKRVVEFGARITFVGSIDDQLVPMESAVYSPANHPYIYRAVFIDGRVHAPDFISHLIGFALKLRNLGISDHGLVRELSVALAGSLYSGEGHSRLYFDSAIYDLAVMHALETTDTAQPTPCVIPKRETTPLASSNPYVLPWIMRGLLEEDFVKTQLSAETEELLRQFDDWKPTNKALKDVKYRLEVVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3N4</accession>
    <name>A0A2T4C3N4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1438907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3N4"/>
    <dbReference type="STRING" id="983965.A0A2T4C3N4"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056073">
        <property type="entry name" value="DUF7656"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056072">
        <property type="entry name" value="SNTX_MACPF/CDC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24676">
        <property type="entry name" value="DUF7656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24674">
        <property type="entry name" value="MACPF_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNTX MACPF/CDC-like" evidence="1">
        <location>
            <begin position="92"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7656" evidence="2">
        <location>
            <begin position="381"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8206" evidence="3">
        <location>
            <begin position="884"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1151" mass="130232" checksum="36001FA5C39EC2D8" modified="2018-07-18" version="1">MYWLVSRLLSHEMQYSGCFNLSRTLYDAKRDQFLKASLFPHGPPESHVSTQPTADTEISVSRCAQTTAVNILSGTLSLQGAAVFLRDFEAGGTVRAAVIHRLSTAQQTIVNLGDTFKSSGGLAALRTQDCTHVVIGIKWGLQTIVAASCSTPSKAGSSESEEATFNRDLEILTSSIELAPLTPQTRLRQSPQMELCDDLTIYSDAFEQEGLAMHSVSDICDFIRVVPDHIRQENSGKGLPVAYTLMPITTLAFLLPLPQEFQYSLTTIRHDYLVDLIQLFDDVEASAAKLRKYHTYLAGHIMHVARGHVDEVLDSIKHLGEGKRWLTDQLFLCLLEVRQGKQDASVLFDLYRHLALTEPTPKQLAALVGQETEKLEFITSVVSQGAKYIGYNGLSLKMIQKAQKDAHFYIFHFDSASMKSDQDWNDNVALLLELVGQRDERMPVFIMDHDAMGSNACLGISRISHHKGNEECRADMLEYRQFLSTKCFARCSDGALDTSKCQRPVKRRFVKIPCPSPGCDSGHSEEWTCPRCFATLEYGFSDEYFYCDCGRGLFSSYEFNCNDPKHNSDFAAYDVEQLRKLLDKLDQENYINILILGETGVGKSTFINAFVNYLSYSTLDEAKDADSLASVIPCSFSLQTMNRDNPELGIQEFNVKVGGRDDEVDGSTGNSATQRSAVYPVTIGAKMYRLIDTPGIGDTRGLTYDKENMADILKTISSYDNLHGILVLVKSNNARLTVTFRFCVKELLTHLHRSATKNMAFGFTNTRISNYAPGDTFKPLKALLDGQSDIPIALSTATTYCFDSESFRYLAAYKQGVPMDNEEKFHRSWDHSSKEAHRLLDYFASTQPHPLCEDKKLELTDTQLTANKLRKRLHMERIQFRATKLEKPRTVCKNTDCCDFKDNGHGDGTVTTIYKTHCHAECYLQNVTEDVVADPGLIKCAAFRGTNVCVVFQHRWQEHLHVLYELFEEKVQVIDKEIQRQLRANVDDVTLRQLVITRLDRDIQEFNEELDEIRRAAARFCLFLRENAITIINDATLDYLDMLIQDEQGVIEAGRQRGLSVDSNKKRLRALKDDRQIHLELVETFKQNMAHPTCPEDMLLDEKGVDALVKKLYDLKHFGANLKHIKYVIDSSIEETYRERPYRYRLSVLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3P5</accession>
    <name>A0A2T4C3P5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1422307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3P5"/>
    <dbReference type="STRING" id="983965.A0A2T4C3P5"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="140" mass="14728" checksum="10C0534A0D4AC84E" modified="2018-07-18" version="1" fragment="single">MSEVISRPSASRGRGSGRGGRGGFAGRGGRRANGDQTDHKTADDNLGAFEDEGEFAELRKQYGDKTGVIREMFPDWSEADVLYALKETNGDATEAATRIADGTISQWGEVSKTKKTARTKAKDASSAPAVADSSAAARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C421</accession>
    <name>A0A2T4C421_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1249921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C421"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="20045" checksum="041947C5494412A8" modified="2018-07-18" version="1">MQLLPFFVACAATRQRPLGSQTFGLSQDSVRSQRRLRQMTSGSLEAETAQTQPLADVRVCMNVVLVCSYVFSLFLILPCRGITTELARIWRRLLASSFALVPVLASLGTDRCEGHNGWQLISAKAALWKRPSDIKLHVSAERGVGERRKKSEWWSRRVEVLTPAQEYRVLDIWCRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4J9</accession>
    <name>A0A2T4C4J9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1431149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4J9"/>
    <dbReference type="STRING" id="983965.A0A2T4C4J9"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000040">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="320" mass="36383" checksum="12A3C9684C63A872" modified="2018-07-18" version="1">MPSLPASVDLDECISRLYKKELLAESVIEAVCAKTKELLMRESNVVHVKAPITVVGDIHGQFYDLIEIFRIGGYCPDTNYLFLGDYVDRGMFSVETISLLVCLKLRYPERVHLIRGNHESRGVTQSYGFYTECSRKYGNANVWHYFTDMFDFLTLSVVIDNQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDPDRDEFSLSPRGAGYTFGAQVVKKFLAVNNMSHILRAHQLCQEGYQVLYDDRLSTVWSAPNYCYRCGNMASVLEVNTQGERFFNVFAAAPENDQHKDMQQGMEKAADGNSLPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4M7</accession>
    <name>A0A2T4C4M7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1333179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4M7"/>
    <dbReference type="STRING" id="983965.A0A2T4C4M7"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="838" mass="95303" checksum="C7F202222D491F1F" modified="2018-07-18" version="1">MSSHLAEESDRELEIPPPLLPEEDHQDQVQDDVLPRDIPHRTTFYDSVVERQMTQTDAKLFYQRSQLEGSTMVEPSQAGSYNDPVASLEYDEDDAASVGKASVGRASVGKAPNPGYDTARLAAEASRGVSNINFLDPQPQVTAELSSISKSIQDIIALRRRYLELSLQRPGDDPRDSPDWEIYPPGDKPGDVFDMDHFMPLPPRDDSLTFRLTDAGVYEVFKDAESTTPVFEVPTIRQFYMDLDTILAASSDGPSKSFAFRRLQYLEGKFNLYALLNEYQETADSKKVPHRDFYNVRKVDTHVHHSASMNQKHLLRFIKSKLKKNPDEIVLYRDGKHLTLAEVFASIKLTAYDLSIDTLDMHAHIDSFHRFDKFNLKYNPIGESRLREIFLKTDNLIKGRYLAELTKEVISDLEASKYQMAEWRLSIYGKSPDDWDKLAAWVVDNKLFSQNVRWLIQIPRLYDVYKDNGLMESFEQVVTNIFKPLFEVTQDPSSHPKLHIFLQRVVGIDSVDDESKIERRLYRKFPVPREWNTKQNPPYNYWIYYLFSNMVSLNRWRKQRGFNTLILRPHCAEAGDPEHLASAALCCHSISHGVLLRKVPLLQYVFYLEQIGVAMSPLSNNALFLSYDRNPFPQYFRRGLNVSLSTDDPLQFAFTKEPLMEEYAVAAQIYKLSPTDMCELAKNSVKQSGYEAAVKEQWLGPNFTRPGREGNTMAKTNVPDRREEYRYHTLLTEREVLGRYATYDPNAEKKSTKADLAIKAQNANIPSASGTEAPSGVATPTSGATHRSTSVAAADAHISGSDPMIFPGFLSRDSSRRNLAKMDSWGVQSAEMSSPGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Y2</accession>
    <name>A0A2T4C4Y2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1431218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Y2"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000483">
        <property type="entry name" value="Related to allantoate permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="517" mass="58634" checksum="DDA2B74BF4AAB844" modified="2018-07-18" version="1">MSPPKSSPSVDEIEDNVEAVLSNEIEKDHIDYRRVDKELAQYISEARITISPEKNNELRRKIDRRILTVMISTYFLQAIDKGTMSFASIMGIKDDTHLVGQDYSWLTTCVFITILVVEYPQNYIISRVPIAKYLSFNIMAWGAVLASTAACTNFTGLVVVRTLLGLFESVCQPSFVVLSAMWYRREEQAARVAYWYMMNGAQQIVGGLLAYCFSLITTGPLQSWKWLFLVYGVISVFFGLFVGWWMPDSPMRAKCFTEEEKRLMIERVRDNQTGIQNREWKRSQFIEALKDPQIWGYCLVQLCTTLPTSGLGAFQGIIISGMGFTVLQTQLLAMVLGFYIIIVLLGSTWLVKRTNQNLYVMTAFILPSFIGTICLMTVPLDTRSQKIGLVVCYNITMSFWAAQTLALSMLSRNVAGQTKKSAAVALNFISWATGNAIGPQVFLAWNAPRYFIAFATHLGCYSLLVIVLLALRLYLARENKKRDNLAASGVREARDERLVHAWEDLTDKENPNFRYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Z3</accession>
    <name>A0A2T4C4Z3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1421723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Z3"/>
    <dbReference type="STRING" id="983965.A0A2T4C4Z3"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000001">
        <property type="entry name" value="26S proteasome regulatory subunit S5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="287" mass="30711" checksum="F6FA8BA12946C782" modified="2018-07-18" version="1">MVLEAVMIVVDNSESSRNGDYQPTRFDSQVDAVNVLFQTITSGNPESSVGLMSMGGKGPEVLVTLTTEQGKILEGLHRTKKKIGGSSHLKTGIQIAALALKHRQNRSQRQRIIAFVCSPVEESEKELVQLAKKMKKGNISIDFVLFGELDDDATQKKLQAFNDAVKGSEGSHLVVIPPSSKLLSDQLISTPIMLGEGAGAGGGGSGANEEFEFGFDPAIEPELALALRMSMEEEKARQERVAKEQEEEAKKASLESVQEENEGSGSGSGGGADKDKDKDSGDKMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5B3</accession>
    <name>A0A2T4C5B3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1421843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5B3"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="269" mass="29741" checksum="12E2F9EF1DA4F0C3" modified="2018-07-18" version="1">MNEAECNILGYSSQASEDKNDRYQPTFPPKEIYYDTYPWRDTPSSPNVDDNENNALCFLMLFNPPRHGPQAITDSGQWVDVNNGMANCVLNRLLLWPWMHTVLRDVVIAMIPAPTTPASNPNDGNDYETISEDCNLPNTSGGTLTFGHYKPNFRTFTNMTFTLKWTLSIALATLEDGAVVFQVGDPSFSTQGALDPSSNLHWGEPVHSSEIFATISAKVGLENALANQHRLYLPAKGYLLMHDPVFNDSGDLLVGMEYNGAPPPTSPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5C8</accession>
    <name>A0A2T4C5C8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5C8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015766293" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="53" mass="5687" checksum="751BF916E7E4CF63" modified="2018-07-18" version="1">MSQVQPALITLLGIFLSGQGLGDGGHYFIVLPSHWMLGGAPHASHRHWSRPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5E0</accession>
    <name>A0A2T4C5E0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1234689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5E0"/>
    <dbReference type="STRING" id="983965.A0A2T4C5E0"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="893" mass="96366" checksum="1EC65B86A76876FE" modified="2018-07-18" version="1">MLPSIPFRIHKTDRRLSLLSPAVTNVHGTKWMEEFKMMCESAESILARGGKELQRPSITRGPDHAAPETLHEGDLYLCNESLEAIEGALGAVCEGVDAVFSAGPRRAFVAVRPPGHHCSANLPSGFCWVNNVHVGIMHGILNHGLTHAAIIDFDLHHGDGSQAIAWAHNSRSMAATKNHAAWKKTSIGYFSLHDINSYPCENGDDEKIKNASICIENAHGQNIWNTHLQPWKTTEEFWDLYETKYSILLDKARSYLKAQADKLQDAGVNPRAVIFLSAGFDASEWESAGMQRHKVNVPTEFYARLTQDVVRLAAEEGLCVEGRIVSVLEGGYSNRALTTGIISHLSGLVGKQNVPQRSRLSFPQGAYDEEDDHIPHSPASLNPYNPSWWSAGEMDKLESAAALPDITPKKPRVGTPPTYCTPTHASTARAVDPLRMRRSMSTLVNRSTVSSRSPSPSPPEVPWTIAASELSKLLIPRDRQTDSCTFEELNTDATRVRRDRQSAGTPELDRSTSRMSLRDRKPRAIDPIQEENQSRQTRDRSKTVAAIAAEKATARGQTPQPIIGMPPKKTNRRLTASAAVPTQRSVSRAAATNEELPLRPTTSAGHTAGRPLSVAGNHAQSSGPSGRITVRRSRPTSSSGEPALRSPMLEAGKETPAEGTTAPAVSRLDATIDDMDKITKGIKKIKINLITQSQKEAREKARLEAEAAAAAAAATAPGELRPSSASTNRSVESGDLKTPNSSVGRRSTINATSPDGTMPALSNASGSTLSTPNLEHFTPRTLSPEARQVVPNVSSPRSAKATDEAHGFLQYQPEGPPPVSVSSQEPLKWLPPSLPAGPPAVQPGPVKKSSTLFQYGGSGTIPFAKQPTNRSPPSQKAQRQPSGSARGALPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5R0</accession>
    <name>A0A2T4C5R0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1331761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5R0"/>
    <dbReference type="OrthoDB" id="4900490at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015395364" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="121" mass="12042" checksum="7BE3BB8E481D1919" modified="2018-07-18" version="1">MKFSLFAIAALPALAFAQSTTTETATTVLTKTVTLKKLHTVTSVASSSLNATTTHAATISSHHLVGTGVTTTYYQPTAPPSTGAPVASATATKGPQNAGVALEASKVALAGVAGMIVVALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5R1</accession>
    <name>A0A2T4C5R1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1376296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5R1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5R1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF36">
        <property type="entry name" value="PROLINE-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="45"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="546" mass="60435" checksum="F255C4F0215E48E7" modified="2018-07-18" version="1">MEKKDSSGPDEAYDVNIEAARPGDSTDFTFAHDGEQLKRGLKSRHLQFLALGGAIGTGLFVGSGGILADTGPAPLFMAYISMSMIVYIVMNVLAEMTVYLPFRGVTIPYYVSRFVDPSLGFAAGWNYWYAYTMLVAAEASAAAIVLDYWKAHVNVAVWIAIVLIVLLALNLFAAAIFGEAEFIFASIKLIALFVLCIIGIVLFFGGGPNQHHVLGFHYWNDPGAFVEYNAKGNTGKFLGYWHAFVKAGFAFITSPELIAIAAGEAVSPRRNLKKAARRFTFRLALFYGVSSLIIGIIVPSNDPRLLGASNASASPFVIGIQNAGIPVLNHIINAVILTSAWSAGNSFLYSASRVLYSMAINGQAPKWFAHTNRLGVPWVAVLFTWAFSLLAFLNVNNSGATVFNWFVNISTISGFLAWIIIMITYLRFRKAMFFNNLWGEMPYKTPLQPYGTYAALFIISILTLTNGFQIFIGDNWNVNDFLAAYITLPIFLVLYIGHKIWKRTPICIKTSEVDVITGKKEMDEMEAMDQPPVPKNWLQRVWFWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5V5</accession>
    <name>A0A2T4C5V5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1238315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5V5"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44163" checksum="CB194A072853FB5F" modified="2018-07-18" version="1">MNSTELDRTFVNLTDDPAQGRGARRTYIRRAVMKNYHKRRNQKKTSSDEYAVAASMRESAWKASMAANELINSRRSPQMCALIPKFRLFEQRKFSEPSLMQMSNSVLRYLCGQASKVCHDLSLVAFLHTSSEQELESDSASPGSKSSPLKTCQNLLRAYGSCKSETLGLSVDKEELWEMIHQHQEWIYAKVTILSTWELLSGAQAVAVYMLLRIKLGYNNIAFPNGDIALLYTLGAIFRRLQVEGTLDITHHPQNDWKRWLLCESFVRVATIYFTLNVVLSMEIGLPCNRPLDWNTEGMLLPASKALWSAGNIDDWKKRASYMSPHKQLTWKDLLAPTLTGDCPVEEWRESSDEMGLLVAMAMTLRAQLLREASQTGSNPYRESSASCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5V8</accession>
    <name>A0A2T4C5V8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-oxo-L-prolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1401250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C5V8"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="241"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="556"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="749"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1282" mass="138424" checksum="103681519F8CE5A8" modified="2018-07-18" version="1">MAIKSLRIRVSIDRGGTFTDVHASIPGRDDIILKLLSVDPANYQDAPTEGIRRILELVTGQHLPRGQPLDLFHFESIRMGTTVATNALLERKGEKVALVTTRGFRDLLAIGNQSRPQIFDLSVSRPEVLYDHVVEVDERVTMEDYTEDPDSVKTTPTPQDTQLVTAVTGETIRILQEPDLSVVRNQLAQVWDQGFRSIAVVFIHSYAYPNHELLVGRLALEMGFSVTLSSELQPMINVVPRGTSAIADAYLTPIIRKYISSIEANFRGGFSSADTRIEFMQSDGGLADYRKFSGLKAILSGPAGGVVGYAQTSWDDEERRPIIGFDMGGTSTDVSRYAGVYDHVFETTTAGISIQSPQLDIHTVAAGGGSILSWRNGLFNVGPESASAHPGPACYRKGGPLTITDANLFLGRILPEYFPKVFGPKENEPLNREIVELKFGELTDDINKDRKAAGLSPFSPEEVALGFLKVANEGMAGPIRALTEARGYDAADHHLACFGGAGGQHACAVANVLGISRIILHKYSSILSAYGISLADVVHETQRPSAIVYSPETEGEIRSQLETLAQQATDALVSQGFSVDQISHNSYLSMRYVGSSSSLMILKGRDWDFKREFEEAHKRSFGFHFPEKDIIVDDIRIRAVGGTGTKQTKTPYAQMKKIQSASVPSPKADGTNPVYFEGSGRVNTPIYELQKLQEGSQIAGPALIIDNTQTIVVAPGTTATILDSYVVIDGALNASKSKNSHGEQEEFSPIQLTVFGHRFMGIAEQMGRTLRRTAVSTNIKERLDFSCAIFSPDGGLVANAPHVPVHLGSMQFAVQYQHRLWEGKLRDGDVLMSNHPSCGGTHLPDITVITPVFDGEELAFYVASRGHHADIGGILPGSMPPTSSALWQEGASIKSTKLVSQGRFDEAEVVRLLLEEPAQYEGCSGTRRLQDNISDLKAQIAANAKGISLIKGLIEEFGLASVHRYMYAIQHTAEDAVRALLRATRDKYGPEPLVATEYMDDGSPIALSISISPDGSAVFDFTGTGPHVLGNTNAPIAITHSAIIYCLRCLVSSSIPLNQGCLTPIKIVIPEGTLLNPGDGLAVVGGNVLTSQRVTDVVLRAFNACAASQGCCNNLTFGTGGKDPVTGEHKEGFGYYETIAGGSGAGPNWVGQSGVHTHMTNTRITDPEVFEKRYPCILRRFELRKGSGGKGRNRGGDGTVREIEFRVPVQCSILSERRSRRPYGMEGGGDGEAGLNCIKVTDPVTGLKRVINMGAKATTRLNAGESIVIQTPGGGAWGRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6H7</accession>
    <name>A0A2T4C6H7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1461928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6H7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6H7"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="51"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="376" mass="42017" checksum="542A85CE1DBF6546" modified="2018-07-18" version="1">MVLSTLSRGAIRSSVAAGASGKRSLSDVAITRTGKTILRTQGGRSSLGGHTATVFGATGQLGRYIVNRLARQGCTVVVPFREEMTKRHLKLTGDLGRVVFIEYDLRNTASIEASVRHSDVVYNLVGRDYPTKNFTLEDVHVEGTERIAEAVAKYDVDRYIHVSSHNANPNSTSEFFATKGRGELVARSIFPETTIVRPAPVFGFEDNLLLKLASVLNLFTANNMQQKFWPVHSIDVGAALEKMLYDDSTAGKTFELYGPKQYSLAEIAALVDKEIFKKRRHINVPKPILKPVAGLLNKYLWWHTLSADEVEREFIDQVIDPEASTFSDLGVEPGDIANFTYHYLQGFRSSNYYDLPPATEKEKREDKKYIHVLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6I8</accession>
    <name>A0A2T4C6I8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1330506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6I8"/>
    <dbReference type="STRING" id="983965.A0A2T4C6I8"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="247"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="59882" checksum="9E8A5DE1A08B3035" modified="2018-07-18" version="1">MAPDQQDSEYPPTYFAHPEHAHVLYAHIALMTVAWVILLPIAVALSLAKSRYVLASQFVFLAANALGLIVGTAYNAQTPDLYPHNAHHAIGWIVTWVVSAQVVVSLLRRLGGALKGAAPTNTAADQLAEERRAFIPLPNGRAASYFGHYRLSNDSGQGSEPTTESLRSNSFSTLADRDAQEPHPDKEMHDADDGDDDLDGPAMPMPMQAPAPRSKTALMALKVVSSRVWKYIEFGYKTVDRIILPFGFIAYITGIATMGRLFEGSAIFSGLAHWIKGGIFFWMGLLTLGRWSGSFHEAGWAWNLRPQRKAGKRWTPSAEFVESALIFIYGSTNIFLEHLGNTDGVWTPSDLEHFSITVLFLGGGSVGMLVESTWLRGLLNTLVTSSQPTSADESAALEPPETYEFSINPIPALVIMLLGKMMGGHSQETMTGTMVHKQWGDLLLGASLARMLTYVTMYLKPPKSVYPSRPPTELLASFGLIAGGIIFMYSAADTIKGMIHYNLEPMSLYTITLGFTGLFMAWELLVLALKGWATRKERNSQNSTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6S8</accession>
    <name>A0A2T4C6S8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_275936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6S8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="233" mass="26122" checksum="9E7C26BB1F36A2C4" modified="2018-07-18" version="1">MLLPAARPIPICRSQNHWRLHAVPLLLRSGVTFDLHCVSVLHFAFVTTSQAWGVAVGDIESTVRSTMATESTVHISSNTLLIRFFHQYPFTQVVPLLFLRPTHQLNLQGTAAIEAAEKPSFRIPRQGTDEYLFTHQRTTQTSSLAKSHATPARRLPLLSCRQKIQRESLGPSRTSHDEVFSTAQQETNPSARGEKAREKAHRKLKPPRQTGSFAALRSSSLLGSSPYRQFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6U9</accession>
    <name>A0A2T4C6U9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1421101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6U9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6U9"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="346" mass="37816" checksum="99C9BDE3DEA40B2F" modified="2018-07-18" version="1">MGSQGGKLICVVGATGNQGGSVARRFLAAGFRVRGLTRNPASPRAQELASRGAEVVQANLDDPASLDRAFAGANVIFSVTDYWEPFFHPACRKEAEAKGISYRRFAYETEYRHGKNIADAAAKVAGSLDANGFLVSTLSHAGKCSGGKFKELYHFDSKADVFPAYVEERYPELAAKMSCIHTGFFYTSFNILPNSYFGKLPDGRVEMAFATDPTKVVPQLAPVDDMGSFTYAVWQMPPGKSYMAAGTNCTWPETIETWSKITGIPASYRQVSPEEMIAACGEPQLGGEITDMFLYTSDPGYDGGMKLLQAEDIRKAGIDCPMTTWEEWARKQDWPAILSRLHGTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Z2</accession>
    <name>A0A2T4C6Z2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1469341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Z2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Z2"/>
    <dbReference type="OrthoDB" id="5132737at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057684">
        <property type="entry name" value="DUF7924"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42470">
        <property type="entry name" value="VAST DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25545">
        <property type="entry name" value="DUF7924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7924" evidence="2">
        <location>
            <begin position="162"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="426" mass="48423" checksum="E622134EFFE777C8" modified="2018-07-18" version="1">MAGCRGLFPAVSDPSTRSSTLFTKFAQLPSCHHGPNSSPGSCQNRAYYRRERDTDTDDPIEFWRRKGRWPSRLFEPGLERVLARKRSSSTLSGRKRANSSSSTPSDQKPREEKDAQYRDPRYKTLLATKGSFMNESDKGIARESKTAYMTLLTAEQTLPTDMRKNEQRVLRFITPLIVPSAEELAMRGSTGLNCLVESMNEGWNNSIPLTGIRPQPDYSVGFRREAFTNAQLKKLSPFVGDFLGGDVSFFMATYYMYFPFLTCKVKCSAAALEVADRQNAHSSTLAARGIVELFRSVKREHEVHRQILSFSVSHDNCSVRIYGHYPVIDGTHETKYYRHPIHYFFFTALDGKERWTAYRFIKNVYETWAPDHFKRICSAIDQLPTKLDLDVPALSESTGLSQGLESSLALPQDGFFSSLIKLSYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7F6</accession>
    <name>A0A2T4C7F6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1330471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7F6"/>
    <dbReference type="STRING" id="983965.A0A2T4C7F6"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="63"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="268" mass="29214" checksum="B8FCB2CE2893E1AC" modified="2018-07-18" version="1">MATVEHCLLCFEALDAELNNRKPLSLEEIQSSWAEYKASSSASASASGPSDAPLNPALRRLAAETASSSSSSSSSSSTSLSAAAASTAATSTSSLPDAPPTAAPLFVTWNTVDPADGEVSLRGCIGTFESQPLAEGIPEYALISALQDTRFRPISKRELPTLQAAVTLLTDFEEADDVHDWEVGKHGIRISFSDRGRRYGATYLPDVALEQGWTKDEALFSLIRKAGWMGSRSKWQDLDIKLTRYQGRKVSLNYPEYKKWRDWVDSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7J6</accession>
    <name>A0A2T4C7J6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1400471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7J6"/>
    <dbReference type="STRING" id="983965.A0A2T4C7J6"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="295" mass="31218" checksum="209EEAED28CE8180" modified="2018-07-18" version="1">MTASDVDEAVVAANLFNVNGLVAFITGGGTGIGLMMARALAKNGAHKVYIGGRRLDVLQEAAASLGPNVVPVKCDVTSKDSLQQAVDFIKQDTGYLNVLVCNSGIGGPQSIQLQDDTTLEEWADSNWSISFEEHTNAFAVNASAVWFTAVAFLKLLDAGNKKGNLEQSSQIIVTSSIASFNKAAPGGWAYGQSKAAATHIAKHLSAALPRWNIRANCIAPGLFPSEMAAPIVNRFNEGSDTPGRVPAQFIPLQRMGNDQDMAGTILYLVSKSGAYCNGLVIVIDGGRLLRFPSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7S9</accession>
    <name>A0A2T4C7S9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1400523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7S9"/>
    <dbReference type="STRING" id="983965.A0A2T4C7S9"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF27">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1133" mass="121173" checksum="5B254EF5EBBCA2B2" modified="2018-07-18" version="1">MDTSQRRMSGIPRPSRLPRPVSGIVQPAPPSPATTSTSSLRPRPSRDSLAGDASSGRDIQNPKLRASTSRGQLRPSAGTTNGRAPSLRNSTSNTSLRSNSSRTPAAKPAAPAPKPVRAVSSSNKRWSTVTNAPAAQYKPWAEPAESDRDTLEAEADTTEPSNDILTSYLNDSAGVPEPLENPESPVTSPGRSTPQITSPRPSLSERTVETLSQLPSSPALSKKSSSFFDSIRPTSRAESSTSRPGSSYTSGGSAAHSSRPGSSAAADDLGFSNPRMSSANLFNRRRSVISSTSERTPTAASNSSQRLRPASRASGIVSKPSASMPDVRSPSPTKMGKLPMKPSPKPVQKPAAQPVKKRTSVYGLNKKPSTQALDASDHPAASSSSWDGTIAAPAAAAKESAAEPEQPAQKSSTALRDQIAKAKAARRAAMKQTPSAASTTTDVPASSNNGFDYDAAFDDPFNLNKGQDAGQQVLKQRIGAARTSGKLNIAALGLKDIPGEVLKMYDLETIGASGSWAESVELTRLVAADNEIETLDDAAFPDLSPEELENDEEGRGNIFGGLETLDMHGNRLAAIPMGFRRFTQLTTLNLSSNRLENGCLEIIAQMTAVRDLKLAKNHLSGPLYPGLADMSALEVLDIHGNQVSALPPNVERLSRLRVLNLSENSFESLPFDGLSKLPLTELDLKKNKLSGTLIEEPIGALPMLQSLDVSVNRLMRLVPADASISLPVAHTLTLSMNRLQELPDMASWTSLITLAADANNISSIPLSFASLEKVRQADFSSNDIRVVPPEISRMDSLTTLRLSGNPLRDKKFASASTDEIKEALSARLEPPPPYEEPAPQAPIATIITPPDVEKKPQPDKVSTIAAEDTDRSEGDDDFATPPTSAPHSPTRSRSQTVVKETWQVKPGGLLDRSRTEASSLSPEMCAELSRSYQIRQAQLHHNLLSAFPGSLQFFSQTLTSLSLGHNKLSGEAYLGEELSLPALTELNLSSNTITSLGPLTRFLKAPALEKIDVSLNRLTALPLDLKQSFPSLKVLLASNNQLTELDPAAIKGLKVVDVSSNDIAHLDPRLGLLGGKDGLERLELAGNRFKVPKWNILEKGTAATMRWLRGRVPAAEMEEWRAENGDDDDSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C857</accession>
    <name>A0A2T4C857_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Epsin-like clathrin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1330937</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C857"/>
    <dbReference type="STRING" id="983965.A0A2T4C857"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="13">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB77723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="552" mass="62323" checksum="DBB53C8C80A3515B" modified="2018-07-18" version="1">MSKVMRSVKNVTKGYSHAQVKVREATSNDPWGPTGTQMSEIAQMTFSTSTEFYDIMDMLDKRLNDKGKNWRHVLKALKVLDYCLHEGSELVVTWARQSIYIIKTLREFQYIDEEGRDVGQNVRVAAKELTALILNDERLRAERSDRKSWKSRVMGLDSDFGPQYAEQSQRRQPRSERRAPAADEDDTEYRLAIEASKYQEEEDRKRRQNRSTGDNDDDLAKAIKLSQEEEERRRRELEDANAASLFDDDTPATSQPQHTGFNQGYQQGNAVDFWANPIDQQAAQIPQPTGYLGTAYTGYQQPQPTGWQPNYNTGFGVDTFAPMPTGNLLAQQQQHQFLQPQQFAQQQHLQPSPALDLAVQPGSNNPWATNHMQQQSLQPTPTGSNNPFAQNRPQSARPATSSLTSLSPLPEQKTLSNFNQPQFGFQQQQQQQQQQQQQQQRLNYTAPQRELSEHERKLNALLASGDGMDTYGNTGDLRIPAQHTAPGTFINSAGAGLGRLNPEATGNNPFLRQQFTGMPSITYGSQPQMSSNPFGAQQRPQQQGQAQDLIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C871</accession>
    <name>A0A2T4C871_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1223372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C871"/>
    <dbReference type="OrthoDB" id="10499107at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16918" checksum="21A0685507959A7C" modified="2018-07-18" version="1">MDWTELECKAEGRRMAASGWPQDSKVSERQGNQLLLVAVPLPCESNVMQGNNSSREVWYGGRPVSKGYRACRGLVVGGLAICGWMELCRVQTAESLFAFARDQDRDQEKSQNNVARHSGAVKQWPRWGKKQSRWAEDGPLVAVQVLWQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8W4</accession>
    <name>A0A2T4C8W4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8W4"/>
    <dbReference type="STRING" id="983965.A0A2T4C8W4"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="557" mass="60830" checksum="CA03D6D4461F9AB2" modified="2018-07-18" version="1">MKNSPFLVLCQCLNTFDVTFRSATRSPNKASTLSSGHPEHSSQGIVADPSGNRLLFDDDDDDEDDDEPEHAYGGEEEERRERHEAAEEEEASRYAATEDEEPIMPLPRSHTPGQLAARSNVPGDHQRGSRGAGELPLRQRAISASHSHSLPRPATAPGHRKMTGTSNPVPDIPPAEADAKPSPAAASSRTTSAVSTRQSNIIVSRPVPGKHTTFPPLPRPDDGPDVSPAPASGMYWSKAPVSGSPHSNLRAHTTTLIGSNVYVFGGCDAKTCFNAMYVLDADSFYWSVPHMVGDIPMPLRAMTCTAVGKKLVVFGGGDGPAYYNDVYVLDTVNFRWSKPRIVGDKLPSKRRAHTACLYKNGIYVFGGGDGVRALNDIWRLDVSDTSKMSWRLISSAEKPAAGARERRPKARGYHTANMVGSKLIIFGGSDGGECFDDVWIYDVERHTWKLVNIPMTFRRLSHTATIVGSYLFVIGGHDGHEYCNDVLLLNLVTMTWDRRKAYGMPPSGRGYHGTVLYDSRLLVVGGFDGSDVFGDVMVLELAVHAYYSQISHFTIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Z3</accession>
    <name>A0A2T4C8Z3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Threonine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_50339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB77988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Z3"/>
    <dbReference type="STRING" id="983965.A0A2T4C8Z3"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="100"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="532" mass="59631" checksum="ADE1CB8D618E4E0A" modified="2018-07-18" version="1">MEPNGTPDENASYRYLSTRGEDTGFSFEEVVLNSVAPDGGLYIPEGIPRATAWESWSGLSFPELAFEIMSLYISPSEIPPADLKDIISRSYSTFRTPEITPLVRLREKHHLLELFHGPTFASKDIASQFLGNLLEYFLARKNESKTSTAADRHQLTFVGATRGDAGSAAIYGLRGKRDISVFVMFPQGQCAPIQEAQITTVPDDNVSSLAVDGTFDDCQNILRSLHADRQANENFDLVSARNWAHILAQIVLYFYSYFALTKQSASFKTGDKVRFVVPTGKFGNILAGYFALHMGLPIEKLVIATNENDILDRFWRTGRYEKQRPGRVGPGGDVLGSGLRKTLSPAMDILTSHNFERLLWFLACEFASSAGMDHYWNQRQASQEVCKWFRELDEKGSFGPVYRDVIRCARREFESERVTDEQTLDTIRAFYRHSGYVLDPHSAVGAAATLRSIYRTRGVVHHISFSTAHPAKFSDTIVRALQGEAGFSLEDKVLAAEFDDLAKREKKVTPMENDWQKVRAHIRARTGHGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C906</accession>
    <name>A0A2T4C906_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-terminal binuclear Zn cluster-containing/DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1437083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C906"/>
    <dbReference type="STRING" id="983965.A0A2T4C906"/>
    <dbReference type="OrthoDB" id="5297881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="124"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="732" mass="79244" checksum="376D8E7D2C45D0B9" modified="2018-07-18" version="1">MNAPHRPPHQPVALPPQRPQVGIERLPARNVTTEPRESMNCKSCRKRKVSCCVLPGRFSGSCSATVSVAHTPHPRGFRAAVKLGDEYATRARSAIDIDEPSIDNLQAIVLLAIAYTASGKGRKAFMLLSNAIGMIMALELHREMDQQAQMTPMERETRRRLFWSCYLLDRFSASGSKRPSLIGDDAIALRLPSWSPAVSGLPVDGDFFLCGSNLQYFQGSGKKSQGSSGMLIDITRILGVTNRYLAAGGVKGDSHFPWHSLSNLSKIRQDLDVWASGTDGVFASMDVLFGQPDSTVLVLCKLIYHLIHCLIYRPFLPISLAELAGNGQHQSWQIEATNMCFFHANAITELAEVGRQMQTIEWPSFVGYCICTAGTVHIHGAHYGKQGASGEISVFSSSSDFLSREMQLLSDLRFTWAIVQHQRDMLQRLYEAHRELVKTITGGAMRYTPGFQLEDFFDRYSNIGGPGGPTFHFDTANLSLADELVDYSNEPTPLSDIQSPWPTENRPNPRMKKPSQSSLQGIPLPLTPTMTVTSYPRQPVPMQPGLMPAPSTPGVGALGEMMPAHMDAQRQQQHHLSAMRSTVDVTSAAHPAMAGFGLGHPAHAGAGNMASMAGMAFSPAFHYNLGPSHAAGGVSQQQVINDSSGGFDAMFGTIPASAYGSPPTWQPAVSQATPGATAPSPSNKSNTGSTGTTGEEKDPFMSLLEQLANDEQRQSSGLKSELDFFLTGGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9U0</accession>
    <name>A0A2T4C9U0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1329583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9U0"/>
    <dbReference type="STRING" id="983965.A0A2T4C9U0"/>
    <dbReference type="OrthoDB" id="5093543at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="289"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="593" mass="66529" checksum="A01058BC84A5CA49" modified="2018-07-18" version="1">MINVGSPAVATAPQLVNREEKTPASRQAEGLAVKPTADTRSVTDSGHKSRIDEATLKGVERLLKLHYLRSRSYNAAMEILYGRNTTSDYELYFDLSGHANITQTGLENLLSKLKFEDILQYVAIPRLNVEVNMNTANSKRSRGSGRSQRQDGDGRRDLCYIFDRLRKRGVKTILKVIIDDSMTPAHSDEAIEDALKFMDVEIWDWKRIDLCSEVICRVAAKAREVNLYWSGNNAVLRGWSEEGGLKKLGELETVYLHIQQEFKRLLFDAERSYFDRGKVKIDESIEEPIKVALIDDGVDVKDLEFNFIGGRTFCTRDEEHNLNDPYYVSSTGHGTIMARQIQSLCPRAQFYILRLEDHASEEGGRQITAKSAALAIRAAVRKKVHIISMSWTIDSPEDEDERRFLDAAIVEAANADILMFCSASDKGAKQNPTYPSKATTKIFTIGAATASGAADSWVGNLGNINFIFPGTKVEMDGPRSGTDNSSREVTGSSVATALAAGLAALVLYCVQVRLYLATDHEKQKARRDFQLLKKHEHMMKALKDIGTTEESNHKFIEVWEVFGKKVEEKERYDQDRWLDLIADVGTILCRKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9V3</accession>
    <name>A0A2T4C9V3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1190820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9V3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="193" mass="21051" checksum="E1854E53A9A5D9F1" modified="2018-07-18" version="1">MTDPLQGTLDEKLLARASHPDQPPRSICPDTCLCCRGLLIASRAGPVKAVVWHANTQTKVDTRLPVLSRSWAWWPPTMSRILLAGPNQLPGSWRQGSNYSTRNPMRAVESRPPLTLSEDFFSPGLLDLFVSQSDDGSRLYLLVVVPPSRPPTSVLLALCIPVQSATGCSLGHRLPSPAPGNRVWPRSTRLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9V4</accession>
    <name>A0A2T4C9V4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1399458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9V4"/>
    <dbReference type="STRING" id="983965.A0A2T4C9V4"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="12815" checksum="C9AA82D8DA0503E9" modified="2018-07-18" version="1">MAGKFEPKVPVQLDPPKSDPISLSTLAAANGVDGAKTYVAIKGKVYDVTGNKAYQPGGSYHVFAGKDASRALGKTSTKPEDVSPDWSDLTDKEKGTLDDWVTFFSKRYNVVGVVEGATNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9W7</accession>
    <name>A0A2T4C9W7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1190876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9W7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9W7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="360" mass="40414" checksum="18E3F87DC453E828" modified="2018-07-18" version="1">MEEDQSQSQPQPSNGDGQPAMGLQDYQFTFGCSAPNSANGSFLEPDPQAGSMMDESMSLTESIFDFPKRFGRTYHAYRSGSYNFPNDKLEQDRLAIQDIAFTKAMGDRLYFAPLDDRPPRRILDIATGTGDWAIAMGDRFPEARVTATDLSPIQPDIVPINVEFFVEDSSEPWIFNEPFDYIHTKTTGGCWESFETQIVQQAFDTLAPGGWFEAQECAPVPHCDDGTLKPDSAMALWFVDFLNAAVEAKRPHAEFGYLKSMMERVGFVDVHQKIFKAPLNGWAKDPALKEIGQLMETNMQMGLSAFSLGLFTKVYGRTPEEIEVSLVEVRREVSDPSIHAYLPIFVVWGRKPFPGEQSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Y5</accession>
    <name>A0A2T4C9Y5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1420493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Y5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9Y5"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="144" mass="15646" checksum="DD5A36F02A2FF7D4" modified="2018-07-18" version="1" fragment="single">MQSRLLAREVGDLPSRDLSQIVASQLLRSFEPAPQHRFNGDTRQLAGQQQKQQQQQHDQQAAQSLGLDPDERPHRLRAHGAGVSSLALDKFDGRLLVSGGADGSIKLWDLDSGCASPHRTHTFRPVGHIPRSTAGPRSGGHSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAK2</accession>
    <name>A0A2T4CAK2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_265433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAK2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="109" mass="12582" checksum="A987EFD92E325BDA" modified="2018-07-18" version="1">MAACRPQWSITIGSRWSTSPMVTRKCLERRRRRNNFHWEQCRAESWRCWLSLILDLAIGELQLQHSGFEAALRTLAELACSLRHDNVHLRFTGTLLGLSSGTIDPVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBF6</accession>
    <name>A0A2T4CBF6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1461870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBF6"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62321" checksum="72E330B76A7DCDAF" modified="2018-07-18" version="1">MTEKVSCNTVRPKKQRKKKTAAVEEQKKRTDKPSSTDVASEREGTVDDNRSLTDRPAASLAPLTDSTWENKGERQHTELLGIEEKGENTHFVDPSLPSTWPKVHINDDKCFRIMTSNYNSSIPPRLDAAAYNEYCFVGKFAQLIMSSRRSYSNNRPQSWILELPHLAAKKALPSSLRYAMHAAALLYHAVTTHDDRAKVAAIGWYLAAIHSYRTTILASTPRKAPVAPVPEVAVGSEGLSISEIAEICVPIMFSFYEGLQGSSSDAELLHHAAATEMLERRGPEKCASGLAHSVMRSLRVREAFYSIMQNRSANFSSPEWLSIPFQQKHKICYDRLIDILLSFTKVLRLPGMNQWGATLRRSVNRVHGLSTSRKAEIEEKALTILAQLQEWWLQFRQEHCEIVTLSSECSLAPEIADLTVASPTSVLMNPLSSSWMVANNETLTASMLSLYSATHMILHTTLLIISLSKAPYLIGPDGQTEVDSHQAAVSTYATGVFNASKHLNMTKPFCGDAFRTTFSMTIVSQFALEDMQRDEARRMLNQWRVHSSQPSRFRTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCW1</accession>
    <name>A0A2T4CCW1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1460969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCW1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="228" mass="24137" checksum="320A94C2C5405847" modified="2018-07-18" version="1">MTLSRVGSPQSAQADGQRFTVSRWAALTVPEASGLSLRHVQALEATVPHSKVVTVAAGAASQGVEEALGFPTDGGDGRWMLGTNEDKRGSAACQSQGANEGPDLEEETEGRQEEVTAPVPSVLVMPAASWPEYLASLRPASPHPVSATECSPKPKSWAERLSRNQGPGGTDESPSNPLQSDSAKPLDHIVTNSVTKKRWPESHAKGRGGRGSQDFNVHKLDIRACLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDU9</accession>
    <name>A0A2T4CDU9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1398987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="6"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDU9"/>
    <dbReference type="STRING" id="983965.A0A2T4CDU9"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="56"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="251" mass="28422" checksum="131D082EF07F0AC7" modified="2018-07-18" version="1">MDSDDYTSTLASLSVTHVYYDPNDYVSLLCAYLALLPQALCVVYATLIFSTREAEICLAFAGQLACEALNFLLKRIIKEERPRRIHGKGYGMPSSHAQFVAFWSVSLALFLLVRHKPRPQQQQRHTKLNSLSSLRNSINVWEGGRPWSLPERLAVSLAGLLVAAATAWSRIYLNYHTATQVLVGVAAGVVFALVWFVATELLRRTGWLAWGLELPPAKMLRIRDLVVEEDMCQAGWEKWEEKKKRKETKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEC4</accession>
    <name>A0A2T4CEC4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1325554</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEC4"/>
    <dbReference type="STRING" id="983965.A0A2T4CEC4"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="308"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="596"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB79890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1273" mass="141971" checksum="C8FC9B3A422561CA" modified="2018-07-18" version="1">MAGIDALLASQEEGISSSGLRKRRLPDPQELKQRLENELLMPSPEFSTEWLDRLQQRWEVEADYTDLFRIAPPQTRTLTRFLRHGLEGRVTGYKNVTVPMSGATAKNSTSLLRKPASRADFVRGAAGFFPFAPGGLEGIEATAALEDQIHAGTAAADDAAAGSKLERVIQLGDEGGLLQTAPGMTRGIDFAKKTAVDEAAAEEIKQELEEDPEEAKGANVEDSSSPADASGDSVEDEENGDDIDDLLPVEFPSLEPHGVLAASSAKKAGREWAHMVDIKHDMPNFRELVPDMAREWPFELDTFQKEAVYHLENGDSVFVAAHTSAGKTVVAEYAIALAAKHMTKAIYTSPIKALSNQKFRDFRQEFDEVGILTGDVQINPEASCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDYERGVVWEEVIIMLPEHISLILLSATVPNTHEFASWVGRTKQRDIYVISTAKRPVPLEHYLWAGKNIHKIVDADKKFLENGWKDAHKATQSKEKAPAATNTVAVRGGNSQGNQRGGAGGRGGPQRGGQQQRGGRGGGGQQRGRGGPPRASHNPGHMGRAGNPGGRTSAAQDKNLWVHMVQFLRKQALLPACIFVFSKKRCEENADALSNQDFCTASEKSAIHMVIEKSIARLKPEDRVLPQIIRLRELLGRGIAVHHGGLLPIVKELVEILFARTLVKVLFATETFAMGLNLPTRTVVFSGYRKHDGHSFRNLLPGEYTQMAGRAGRRGLDKVGSVIIVPPGGDDVPPVAELRSMILGEPSKLKSQFRLTYNMILNLLRVEALKIEEMIKRSFSEHATQQLLPEHEKDVKLAQADLAKVKREPCKICDNVVDECHQAAQDYKRLTTELYKGLLKISFGRRMFSPQRLIVFNWDGIRTAGILLAEGMSPKGSFEDPILHVCAIKPLRERRDITDQLPFIPAFRKYMQKLPQGKRRLTTKNMFVPLSDVECLTRWVLKGVIPEIFKGGAPAHEALDKIQEICSSWDDRWDEIDMGKVKSLPLQEMMEKRWQLSKTMANSAALQCPAFLKHFAMCHDEWLITEHIAQLKQTLSDQNLQLLPDYEQRVQVLRELDFIDESSRIQLKGKVACEVHSGDELVLTELILDNVLADFDPAEIAALLSSFVFQEKTLTEPTLTGNLERGRDTIIAISEKVNDVQTRLQVIQSSEDSNDFVSRPRFGLMEVVYEWARGMSFKNITALTDVLEGTIVRTITRLDETCREVKNAARIIGDPELYQKMQQAQEMIKRDITAVASLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEM0</accession>
    <name>A0A2T4CEM0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEM0"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="540" mass="59354" checksum="EE3311D182744A1E" modified="2018-07-18" version="1">MAPPTFAGLSGRPLSLCVSTIATTAFLLFGYDQGVMSGIISSPVFNDYFPETRDATMQGLVTAIYEIGCLIGAVFILAMGDLLGRRRAIIIGGIIMIFGTIIQVTPMKGHGQLAQFIIGRIVTGVGNGINTSTVPTYQAECSKTSNRGLLICIEGGIIAFGSLIAYWIDYGASYGPDDLVWRFPIAFQIIFALIFSTVMIWLPDSPRWLLTHERYEEAERTIAALRGYEIDSEETKAERDMILDSIRASGFAGQKSTPVKALFTNGKTQHFRRMLLGASSQFMQQVGGCNAVIYYFPILFQNSIGETHNMAMLLGGVNMIVYSAFATVSWFIIERVGRRKLFLWGTAGQMLSMVLTFACLIPGTPSAAKGAAVGLFTYIASFGATWLPLPWLYPAEISPIKTRAKANAVSTCTNWLFNFFIVMITPIMIDRIGWGTYLFFAVVNGCFFPVLYFFYPETANRSLEEIDIIFAKGNAENMSYVKAAKELPYLSRQEVEAYAIRYGLVNSGSDGVAGREVDASSEKGSSSEKESSRETENMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF41</accession>
    <name>A0A2T4CF41_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1114445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF41"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015529866" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10538" checksum="BC8107A22BE5DF70" modified="2018-07-18" version="1">MMVLLLVVLRMAFRYCLHMFGRSDSSKPPRFKLDAFPLSRAPRTATDVDREELSSTSLHFTHRSAPVVPIERPARESNSGGPSTPRALAQPLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFF7</accession>
    <name>A0A2T4CFF7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFF7"/>
    <dbReference type="STRING" id="983965.A0A2T4CFF7"/>
    <dbReference type="OrthoDB" id="2555959at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="74" mass="8242" checksum="CC1E817DA29CAA1D" modified="2018-07-18" version="1">MQQTLQEKAYKNLTPNTRLGVGVAVIAWGIAGLYISDKAEESFGFTPTEEDKAELRNMAPRITTVDKKTQDQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFY7</accession>
    <name>A0A2T4CFY7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear segregation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFY7"/>
    <dbReference type="STRING" id="983965.A0A2T4CFY7"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51529" checksum="74051B3EEC706E20" modified="2018-07-18" version="1">MTTAAASPAPAADAAPAASAPATRPTRPDENAFKEALAKAEKEHKASMDKLNAIKAKIDVALPNKNKDQPSATQKRRQELIAQANEIRQKQAGGKNARTSKLDQIKRLDEQLRSRVNEQKAAKAKVPFKSVEDVDRQIEALDKQVNSGTMKLQIDDLRAKIKEIKDSMEDPEQKALSEQYNKIQAELDVIKAEQDEAYKNLSSLRDERTKLQAEQQEKFAAIRKLKDDYYGQKKAYQAYEREAREKQRERQRLERERYVQERKKADAERVLAEASEPAYLDEIRRANSLLAFLDPSFKAEKTPLLADSGLTAQAQRTVDESGLKGTKLVRKEDREDEYAPAQSKGKKGKKGKSGAAQKGFNCPPSVVEDCAFLSLDPPMREEDVPELIEKVKAKLAHWKEDQAAQTQRNIEKAKKKLEELEKNEKNENSTNGDKVEEATAELKETSLEDKEKKEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGI7</accession>
    <name>A0A2T4CGI7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1419208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGI7"/>
    <dbReference type="STRING" id="983965.A0A2T4CGI7"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28492" checksum="48683894B41295A9" modified="2018-07-18" version="1">MSTPAWPTYPFSPLCSRQQKANLARIRDNQRRSRARRREYIAELEQRLRAYELSGVEASSEVQLAARRVAEENRQLRELLHKHGFQDEYVSSFLLQQAGTSSSTDPVQALQQIITPRRPVALESGMPFAMQSQVTREMASGSLSAATAAPWDPQQVAMSPFAHPHVAAQQPVVPPAQHPYASPVFTEGPPASLRSSSFQQMNPSTSLLDDVSQHSGTTQPSVGENPAAMSYIHMNPYQNPSARDYPPGPPPPPTGGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH41</accession>
    <name>A0A2T4CH41_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid phosphatase/Vanadium-dependent haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1396023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH41"/>
    <dbReference type="STRING" id="983965.A0A2T4CH41"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="114"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="434" mass="46958" checksum="CA035757A3CA9F37" modified="2018-07-18" version="1">MAQSGSDAKKGRPSIRLITSYIFDWVILLVVAAVGYVLGVISPQKRPFSLVDPNISFPFTEHETVPDWLLFVLSVGVPVVIIIIVSIIFVPGATVPKNTPASLIWRRKLWELHIGLLGLLMSVACGFFFISGIKNMCGKPRPDMLSRCQPDLENAAKYLIGGFQGESKLGNSIGQLYSADICQQTDKAKLDDGFRSYPSGHSAASAGGLLYLSLFLASKFAVTMPFVATGAHSSNHEIHAAFPSRLGSAVEQYDDDATAPMTGKGANPTIAYNSSIQALRRQAAAPPVYLLVITVAPFCLAIFIAASRWFDFRHHGFDILFGFLIGIFTAIFSFRFYHLPITVGAGWAWGPRSPDRAYWAGVGRLGYVADNDLERAMPRAATFGESTDVEARGASLSMPAAMSYRSPVSGGDPYQDVELQNLQGGPSHGAQRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHG0</accession>
    <name>A0A2T4CHG0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHG0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHG0"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="39201" checksum="A07A4BA0D3B15E6B" modified="2018-07-18" version="1">MEYLPVQEFEAVTGALNFNTPDCNVTGGCDLYTTKSTGSDKKLYKNIDKDLSSQHAALLKLGASLSPPDREHMLATSRSMQLFSHSSAFGPLSELSSRRTFAYLIATLNASHPHYDFSHVLRPGDFKRERNLKRVMANLDSILQNTRPGVEVGTSYDSSAGSDVNAQWGPHCWSLIDKEMRLNECTIFSYHPEVDPFEEDESAIWAVHYFFFNRALKRVAYLYVRVVPVISSQSPNLRPVKGGLHKRHTALESDSAKKRAKYWLGDQDAELIPPYEDDEETLDDGLYWNRGEDGDILQLSDDDMAEDEPLDEDEEENEDDDDDFDMISPRRERLMSEDIAGRMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI50</accession>
    <name>A0A2T4CI50_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1435073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI50"/>
    <dbReference type="STRING" id="983965.A0A2T4CI50"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="598" mass="64711" checksum="69B32E2855194BFE" modified="2018-07-18" version="1">MPTGDANGTMNPFAAPFIPLASSQPSFARQHGRQSRPASQAQRSNKESPESSQNQNPRPTAPTSGRPALQNPSGQPGVESPKSSDHVPKSSQGKYKGRSAADGTTVKSSSGPSIGTKQHQRSPEAKVPQTLRMSGENIPSDTNNGGAQVNVLQPVPMAGMRALAPMPLGPYPGYMHPVIPPPPYGPAIFQPRRPPLPLPALPPPPPPPEPCYPLLHLTRCQIVSVSTGQPVPDRYSFAYRVTYWPLRLYAPPGTGARTDGQNPNLPPEEMNPSGCEPLVFGSHRLTPLAQLVNTSGGAGERQAHSTRRDESSDVGHDQHLSDTSTDNGSETGTEPPVACQSSSQEIELPSAVDCSHAGEENTQASPQPQQGRHVPSSTQVPSNVQTAPTSQQHHNAAQGPAQPTRLSKKVQPSNQPSHKATVEPASWSQSKRWISSETKERKAFQRMMLNLQFMKADQSPFVPKTPAELTKFKISLAEAKRQKLAQEVSILEEKNRQNELAKAAGTISVSQPHVPLFHGRDMEDELSPVFAVRNCFNKQDTVEVNKRLEWPSLAELKEDGDRRAKCGRFLPLPRIKVTANQAREKQQAHAPNGDGAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI61</accession>
    <name>A0A2T4CI61_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1396391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI61"/>
    <dbReference type="STRING" id="983965.A0A2T4CI61"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="206" mass="23199" checksum="E23C46214C8EE0DD" modified="2018-07-18" version="1">MGISRDSRHKRSASGAKRAYYRKKRAFEAGRQGANTKIGAKRIHTVRTRGGNHKYRALRLDSGNFAWASEGCTRKTRVIAVAYHPSNNELVRTNTLTRSAIVQIDAAPFRQWYESHYGQPIGRRRQKAQAAKEGKEVEEVKKSKSVEKKQAARFAATGKVESAVEKQFEAGRLYAVVTSRPGQSGRCDGYILEGEELAFYQKKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIA1</accession>
    <name>A0A2T4CIA1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1387717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIA1"/>
    <dbReference type="STRING" id="983965.A0A2T4CIA1"/>
    <dbReference type="OrthoDB" id="2748312at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015625095" evidence="1">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="276" mass="30483" checksum="3406DFFC3EEF20DC" modified="2018-07-18" version="1">MTYSITAQTSILLLTLATTILARPPDITFLCDEVPEICTNMCWAVRCAKPSFSQTFTFTFGPSSYGPSSNSTSISGSCLTNELCSNAGLNMTGHRGGCFTACNTYPLSVSSEDAPDLPQPLHRVSRCVPEAEQGRQQTQLDLFARSLQRPQRNGTQPQQGVRHLLINFGNPGGVKYCNNDPCINDGFEVQDGSVGRRWLRPEAAAPMFTYYKTKSGIVIASLENVEMPSRFTRRVGSGELVPPGFKTWFERATEETVHMMEDTILQRLSDQSFGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIB4</accession>
    <name>A0A2T4CIB4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1396409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIB4"/>
    <dbReference type="STRING" id="983965.A0A2T4CIB4"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="565" mass="61302" checksum="1408330FD367D96B" modified="2018-07-18" version="1">MDSDDDDAMRAFLPTSFGKQSKEADIAAQIERARRKVEVPSGPGDEPKKKDGSGGSDSDNDSDDSDESEDEDEFPVSHEIVLKTQERAVTSVSLDPAGGRLASGSLDCTIKLHDFASMTPTTLRAFRSIDPFVSKRTAASAEAHPVHHIEFSPLAGGAMLCVCAHPQARILSRDGDILTEFVKGDMYLRDMHNTKGHISEITTGTWHPTDRNLCVTAGTDSTLRIWDINNKRSQKDVIVFKSKAAGSAGRTKMTAVAWKNSAQGSSVLIGAALDGSLVMYGGNGPFTRPAGEIREAHKAQTSTSGIDISSDGRMVVTRGGDDLIKLWDLRKFDKPLVTVSHPSTSDIYPTSNIRYSPNSTSIITGSATGHLHILNPGNLQPEHVTPITPGSALIAVEWHPKINQIVTGSANAETHVLFNPSMSSRGAVEVMSRAPKKRHIDDNPEFTMDQNVGLSGDSIVTPGAMQGSRKAGVTGTGKSKDPRRPEVPLQTPFQKSQPDERHIAENIPLARMLHEDPREALLKYADKAQSDPMFTKAWTKTQPETQYAQLSDDEDEGPEKKRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIC9</accession>
    <name>A0A2T4CIC9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1322286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIC9"/>
    <dbReference type="STRING" id="983965.A0A2T4CIC9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000510">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="8">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="292" mass="31570" checksum="2FA60E6964740A02" modified="2018-07-18" version="1" fragment="single">SAAGTTPDSNTLASGSDDKAIRLWDRVTGRPKTTARKAGQEMAPLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTLVVSCSTDGLIRVWDTSTGQCLRTLVHEDNPAVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIGGCFGVLDGEAFVASASEDGDVLLWDVKSKEVLQRVHGHEGVCFWVDVHGDTMVTAGQDGSVKVYRHVRQSGEVNGDGAKSEVKAPGQGMLQGELPIRQDDVKAEDVMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIZ4</accession>
    <name>A0A2T4CIZ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1427384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
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        <property type="protein sequence ID" value="PTB81525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIZ4"/>
    <dbReference type="STRING" id="983965.A0A2T4CIZ4"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
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            <begin position="188"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB81525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="432" mass="48587" checksum="ED4316BC2AF930E9" modified="2018-07-18" version="1">MPGVTSTEPQPQLLFVDGSFEDLAREMADYLKAEEAKQLLSGDKEADKEEVLSKLVAASSALSTVPEKEFTAASNLMIHLAMQSSDPKKLLPTLCANLSKPLIGSPVHGAGLALNALVTVFNLLEPNDPVRARVFQQILKFLKAHGMFDGLRGYLDKLPEWIESWGTDAAMARKIYEDVAEVALESGVENTAYEFILKALRTFDGEEITSEDAQRLSLRALKMAISSNTHYLFQDLRAIPSVQALSDSHPVYSQLLDIFAEQDLEDYNDFNDEHKGWIEEQKLDGEKLHRKMRLLTFASLAAATPSREVEYAKITKALQIPQEDIEIWAIDVIRAGLVEGKLSQQRQMFLVHKVTYRVFGQKQYQELATRVDHWRSTLQNVLGVLQQEQANAKAAKLREVQELERKLANANVGGHEGGRRRQQQRERTDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJM3</accession>
    <name>A0A2T4CJM3_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1435458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CJM3"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="338" mass="37572" checksum="A1ABEAAF5CE8C244" modified="2018-07-18" version="1">MSRSGDEGLDLSSDDDLIEIQFDVSQASAPSSRGRSIFHDLLHPQGVPPRDSTMAGSVSLRPTAGHSRRPQPAQSSTASQPRGRHSHPQSQQASMLRAWAGASASSSESRPPATTYIDLTDEPDSPVERRRTQASDPQAMLQQVPNNIAGRHPRRTNSQRISPPQLARSDSTLVGGPSSYIDLTVDEDEQQQQQQRSGREHWRTRAAHQRPHHHHHHHHHHTRHNEDHLVALRLMGGSHHDQLESGFRVLGRTLADILTGNFSASLNPQNRFPAEPESRPKPPMEPIPSATAGFTRDTRADGQGCREKEKNLPQRLRHPSIRSRSNVASKTEWVGIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJR4</accession>
    <name>A0A2T4CJR4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1323404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJR4"/>
    <dbReference type="STRING" id="983965.A0A2T4CJR4"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="964" mass="104674" checksum="54DE39617FEDB256" modified="2018-07-18" version="1">MPPPLSSSADVGDSQLASTKDGNTKSPANGTAGSSESRPLPVPTRRSTTLLSRAPTQQPQNGREKEKEPKGVMIRTMSSTPPTPAALDPLGTQIFLRTNSGTIETSLAQRLRGSTKPDSPTTESFPRKSFGIETTARLANALPEPSKDRKKGTSFLSRFGMRSAFRRYDNDAPDSDSEMGEQRTEGSSARAPMSVLSEGGGYIPLYKEPPRYIRVKAHNSRRRDFNRLFLAQELLGPKPDKDDEPSHGRVPATAVGTKLLKAGDAIWAAEFSLDGRYLAVAGKDQVVRVFAVISTEEERRAHEAEEEADREAQGKTKGERLSAPVFRNKPIREFQAHTGEVLALCWSKNNFLLSTSMDKTVRLWHISRQECLATFAHHDLVTSIAFHPTDDRYFLAGSLDAQLRLWNIPDRTVAFSASANEFITAVAFTPDGTTAICGVLSGMCSFYETEGLKVKFQIHVRSSRGKNAKGSKITGIKTATAAGTDEVKVLITSNDSRVRIYNLDSRSLEVKFKGLENQSSQIHARFSDDGTYVICGSEDRKAYIWNTNASEADAKDRQPYESFDAHPEVVTAALMAPTRTRQLLSASGDPIFDLCNPPPVLLRSLDEAALSQTEVSEAGTEIHHPAPPSSIKKPEETPAYLERCKHLDGNIIVTTDRTGTIKVFRQDCAFAKRQQNMWELGSKFSSKVSGLGRSGSIITRTSGSMSRRTSLNLSAGQAQHPSDRIISWRQDVNDEGARANVTVTPARSERSASPRKLPRSPANFSSTTNPAALARKPVPSSGSSARPQRNSLASPTGSIRSRPSIGTLDGGSQPPTPSFNFISVAESDENEKEGGFWNLSRWRGSISGLRYSVSASSPTESTHEAAAAATGDGQSRKPNDLLKPPTRAAARRSIGVTDLNRPKVVEDQASRRKSTGPAIQSSKSQETTPGMGIIDEDKSDQSLSKRRADSGLGRMSDDAAERGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJW9</accession>
    <name>A0A2T4CJW9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJW9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJW9"/>
    <dbReference type="OrthoDB" id="3561681at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="61045" checksum="D18C9665FCC0056D" modified="2018-07-18" version="1">MSWISRKFEPDKNDRDLLRFSKGKNEAFRIYKHEERCSDSSCASTEPRTQSSKLEREDEWESWLRTTEQPPGRTSCGGDESKGFGSQSTGPPSILNLVMGGRMSSLAKMPFSEQVFTELASRLNIHRSVIRAINRNTSCTFLRITYPESIVYTCRTAESWPEDMALSVTFFPSTMTTNAIWLGCDLEQRLIHGHELTDSAIITSKLRDFDGQVFHPMMLPTIFAEFERDRHIGLVRKSNTQFVQRMIDIESRNDWFYGIQQIRGDVRQSQEKESPSSSRSNSFFNGMKGRVESFLSGKTASTTSTFNTAARSETLHNEDGVMDEEEEETCAMLWIKISHLKNGLENWKTQLRKMVEHTKELEDRDFGMKRDVQTHAWVRRRDALTECGARLRERLQDLMDEYDDFIRECDHIMAGMSLATQLDLNHIGRKDARLNENISRSSLAVAETAQRDGSLMKSIAVLGMIYLPATFVCTFFSMGFFQWRGQSESTTTVSPDLWIFGLAAVAFTLITVGVFLVCTMRRRDSVRSKLHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJZ4</accession>
    <name>A0A2T4CJZ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_94934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJZ4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="106" mass="11674" checksum="CFC9EF9B567694A4" modified="2018-07-18" version="1">MLPATLMLLYIPTFQNKRSKNNVTPFVTPTAPFTSSSKTSSVQVPPTIPPLQTHQSSCSSTWPWSPSLPDRDTRAASPAESASPSPPHPHRPRAAREAEDEPRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK84</accession>
    <name>A0A2T4CK84_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1368554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK84"/>
    <dbReference type="STRING" id="983965.A0A2T4CK84"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="365" mass="39666" checksum="5AA4DD7BD91B6A63" modified="2018-07-18" version="1">MAEEIHRLIKANEPSEVKEAVKGGNLINEFSAAGLTPLGTAIVCENLAIARLLLENGADISLGYNSDLCLDKSRMQSELPDICPPIHMASAMGLSDHIRLLVEYGADVNDPSAVEYGAQMLPLYLSTKDATKTLIDLAADVCRKNSTGFTPLLHAIAREDITSTRLLVENGADVEVERTTRYRLRVATGYNAEQAEERLVEGSSSPLMVACHQGRLRPTSAQMIQILAAAGANINRRFQIKNVKEEIGFTALSLICGSRTPAPLVKGAYAKKDQYGEKEVAAIKALIAAGADIDNPPVVCYVCDGDMPFLDFKCRLEVIRALVCRGMKTDIQVALEAQLSVSRLRFQQPEAQDQLKLIQGLLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP40</accession>
    <name>A0A2T4BP40_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1155888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP40"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="64" mass="7254" checksum="5D97DE7B5D9730AB" modified="2018-07-18" version="1">MHGQRKRSNKEMNLTLLILITPNVYFVVLMDKIKSSGVCEMTGLRGTALWHGHGLLGSIARRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP97</accession>
    <name>A0A2T4BP97_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1366194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP97"/>
    <dbReference type="STRING" id="983965.A0A2T4BP97"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="400" mass="45777" checksum="B1D4863D7FCEEC91" modified="2018-07-18" version="1">MPTTHHCQCCNKNGYCKDHQIQCNVHPKVYYYRSDSTGYPKNQQEPKPQSLDLDAGEAAIFRSVTLLAKGGYNTVWLVRLHGYFEVTRVASSGQDDSQTVTRSFNEYVLRLPCEDALFPYQITNEVAFKKFISTEFPHIPVPLIFFHQATDTHSTSFIAEEYIDARPLSSNWMSLTAEQKELMAKQLAKITVDFAGTCFSMIGGLNPDNFQPAPTVEGVKIFKGRRKFHSRQYYPIGPYRTTKEYILACYEREIAYYSHADEEDIEQDLFEDVSASDFIKRLQQKRDSLATIDMEDEPFTLVHGDFHGRNILTKGDQILGILDWEFAGSYPVSETLSGGGIDVVEAESEELDDENTLWDRRIRDFIREEAVARHWEGDKLDLLLGNGNLELARARVEMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQI4</accession>
    <name>A0A2T4BQI4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1142759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQI4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="13395" checksum="8DFD389F546BA3EA" modified="2018-07-18" version="1">MPCWRNLGIHNSILKPPPLRSIVRLWPQLCAIASDTTLTDSFQAHFGQRLQRNGLAPLDRRYSARLSSTRGRRTDPGLALALALALASSTSSSELVVPVLFSICLSLSLALSLLVSALLLLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQK0</accession>
    <name>A0A2T4BQK0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1142723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQK0"/>
    <dbReference type="STRING" id="983965.A0A2T4BQK0"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="13708" checksum="A8EA7E1246D354B2" modified="2018-07-18" version="1">MRSKFKDEHPFEKRKAEAERIRQKYSDRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQK8</accession>
    <name>A0A2T4BQK8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_212364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQK8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16907" checksum="70FE4599F15A2373" modified="2018-07-18" version="1">MAPNRHTTCRWLGGSGGGQRSCQWMVFLGPSFRAFRADAIGERSEARRGEAARRNAKSPWLSVAARASPPRPPGGRLWPSLQPGLCGRTGLIARDRIAAHESQRRVPFPMTTEGPRINVKDSDARRGHTSSWEMHGLARGERSKRRDDLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQW1</accession>
    <name>A0A2T4BQW1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1386011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQW1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQW1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="331" mass="36212" checksum="C9743F41054E7A68" modified="2018-07-18" version="1">MSALYGLGSVIYGKVCVTVPIPTTSNDLSDHIIIVTGSNSGLGFEATRHLSRLGVGKIIMAVRTLSKGEAAKKQILQSTGKPESSIEVWHIDMDSQDSVKAFASQAALLPRIDGVLANAGIMTGQFTLSDGNERTLNVNVINTFLLFFLLLPSMRSSEQRTGNPCRFAIPNSALHYMAPLAELNEKDTSILDRLNDPKRADMAGRYPLSKLLVLYVVREIAERTKSSNKGEFIINTPNPSWCRSDLGKEMESAGYKMAEKILARTTEEGSRTLVHGVLADETSHGHYLNNCHVQAPAKHVTNRWGQGVQKKFFDELIIKLDSISPGISSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRB1</accession>
    <name>A0A2T4BRB1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1426182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRB1"/>
    <dbReference type="STRING" id="983965.A0A2T4BRB1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="263" mass="27561" checksum="0D0B9D15C07A9196" modified="2018-07-18" version="1">MADSLALTNKVAIVTGSGRENGIGAAIALTLAKAGARVVINYVSDATASRAEVVRAKIEEAAGKDSVIVVKADVSTEEGCKKIVGEALSKFKVDHIDIIVNNATAVTAGPVLRNSAEDISKAFQVSVLGPILLLQAAYPYMPKYSRIINIGTVASRLGFGPMPIYGAVKAAMDQLTWSLAREIGRDGKHITINTVAPGPVKTDNLPDTPQAAALANWLVELTRSEERIGTLEDIADAVLLLVSEKARWITGQFISVSGGINGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRG5</accession>
    <name>A0A2T4BRG5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1343329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRG5"/>
    <dbReference type="STRING" id="983965.A0A2T4BRG5"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="31772" checksum="92B7DBC24FCC51C7" modified="2018-07-18" version="1">MSEYWKSTPKYWCKHCSVYVRDTKLERANHEATAKHQGALKRSLRDLHRNHEREEREKERARREIDRLNGVVGGSSSGSSAAPAKAAAPTEAHLKSQREQLAALGVAIPTDFRPEMAMPGEWTVTKTTIIEEKPEGDGETSVEAKAIGVRKREETDEQKEEEEAMRGLFKKPRRWGRDSKTMPDDEDQDLDALLSHAVPLKAEAKREEDAVKKEEDAEDGDSAKVKTLKEEDVPIKSEPDAELNGKEPAVDRDPVVKAEETEESSGIAPVVFKKRKPKGIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRM5</accession>
    <name>A0A2T4BRM5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1405971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRM5"/>
    <dbReference type="STRING" id="983965.A0A2T4BRM5"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="174" mass="19502" checksum="8ADE863EB7872097" modified="2018-07-18" version="1">MAATRSAALKLDWVKVSQSLGLRGQTVASLQAFKKRNEDARRKVQQLSEQPTAVDFAHYRSVLKNQAVVDEIEKRFKAFKPTTYDVTRQIKAIEAFEVEAVKNAEATKQAVDLELKDLAATLKNIEEARPFDELTVDEVAAAEKSIDEKTAELVSKGRWMVPGYKEKFGDLAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRT2</accession>
    <name>A0A2T4BRT2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1442282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB72004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BRT2"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB72004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="159" mass="16205" checksum="73351D1EBDEEA3B0" modified="2018-07-18" version="1">MESELAPKFAPFVGMGGIAAAMIFGCVGAAYGTAKSGIGIAGVGTFRPDLIMKCLIPVIMSGILAVYSLVIAVLIAEDLAAPSSKSYSLFTGFMHLGCGLSVGLTGLAAGYCIGIVGDSGVRAYMAQSRIFVGMVLILIFGEVLGLYGLIVALLLNTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS81</accession>
    <name>A0A2T4BS81_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature requirement A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1364360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS81"/>
    <dbReference type="STRING" id="983965.A0A2T4BS81"/>
    <dbReference type="OrthoDB" id="3177213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="72997" checksum="8DBA41CEF996C65A" modified="2018-07-18" version="1">MTEKDSHELTTREKLRLMKSPVVLGSETSVEMPNLSEFGDRYTDRSIEFARHEEAGTLEVFTDLFFAANYAVFSKTQSVTSHERVASYIGYFCMLWITWLVVGLYDVRFVTDSIFERIVRAIHLGAFVGFAVVAPKFDPSNQQAATMRAMSLILMASRLGLTIEYGSILWHVRKFKKVHLAFYLQMSIHFVAAMIYLGVTFRFTNTHHSSVFVTWYIVGVLEALLTFGLSLRYSVLSLSKTHLMNRMFLLSVIILGDSIVVIADKVVIIVDAPDSWDAITIGILTAGVATTYMIFLIYFDWMKASHLPPVRQVIWTVLHFPFHLALVLFLQGFTQFIQWSKVVDVFNHLAANWIVFDPPRLAHATSQLVQQNMTDEIANFFNLYPPKYSDTQYVFQEALDNITNIPNSFWPKWADALTDENYELPTDMTTDLFSKILEALVTAMENSVFTNFEIDLEAEAVKEQREKGEEITQSAADFSAEIDQATWDRYNLVFTYGYVAAGCCLALMVLLSVVARVTPWKPWHVIRTIIYFLLALGMALTALLNLNSVQLDRYLSTPWLLPTLCIAWGIVLLLTHIRRDTPLFFKRGSPRPLRRGTNQSESNNDSEHAQPMMEGSTSYSGAAGMSYEYQPAPQSQPGHDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS83</accession>
    <name>A0A2T4BS83_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1342630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="3">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="323"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1529" mass="173059" checksum="10E672C4EE480E2D" modified="2018-07-18" version="1">MGANGGEKIVVPEDLENDNRDVADLWKQALKQYKGIVGFDLQPKFNNVQAMIDFGTNEMDAFHKFRHNSKKVDKLRSLFAANMDYIKKGTQQLISAAVPAFPPAAAIGTAITYLLSACRQVSADYDVVVVFFDDMNSFLQRVIILETRLPPHKAYQKCLMDVFTSFLTLTGYAHKYIELGRFKKWITNLIEGEDSDLGGARKKMDKDLARLQNATEFAILGNSEELKKMSAELQINQTAHTQMLEEQKEVMFNISQDTGSIRSDVAKLLKAFTEQNAKHDHKGKPSNQDAGKPASANQVRNRMPDIEGEGHEYQVLKETLIPDTCTWIFSQPEWEAWIKQDEDTTALKPLLALSGLPGTGKSHLAASVYDRLYSIAKEDTTQRICVTQFYYREQQKDLSWFKSGLINTITQVVDQSVPLCERINAEMVRDEVSYNVFVWRDLLLKILGPAFSKDSPNRLFLLFDGLDEMFDFSEFLEFVRIAREERFRMTIVVTTRPELLQQLTEKSEVSTIEVTKEKQLQDFKTLVWHRINDLRCLKKFSRYVQQRIAERVEEVSPNLLYAEHTLERLNALGREGAALQILARPMPDTLHGVYEIMLDECQRRMPVARQQIASKLLHWIAFAYRVLSLDEVTSLLVYLSKDDSFNLEEIPEVASKFLQVGDPAFDAQSREIAHRDTSNGSIEDLEKEETASDNQDKMYNDGALPVKFKERSMRAFFRDAVNGNSLWHLKTSEAHRQIFLACVDLVKPEPLGPGHKINDGLRLYAAYRLISHSSQLVWEDYTTQEKAEVMEGLAMALSHTDFSETLSRTGMTYNRGLKSVLNDRVAIWAESLQVPEIASLLSSDAAAWWADVAADPRKCRYGMVKGYVRRLYSAANLDEALLAYKLLYGLLGTSGLDHLLVDSAKRNFPDEVSAPNTTDSEGPPDSDDDADNQATEDPGEERSSLGLPGIFDEIEMDATAYRAVGEIFCNYGYFKPADSMCNKSSELCRSGSDSTERVKSSILHTKVLWKLQEKDRAFEVISECLKDIETADVPPSLKRSALLAKAELEGKLKMRDAAAESYTKAKAIDPTGATSGDALEREIELFEKVADYAGYFRTLKNWSPIDRLTWMAWNYCNQGHERHDKLRSLAFREGEVDFLIEAYKDAIRFLDRLNSGAPLRLELAVTYFRAKGDLENARKILDEIFASTSAGYPYSITDEEPQTMMQRLVDVMSDVLFEIFRNSRDPKVKLDALESLKGIMNRPLSLSVPIYTSSDLVYRRIVLASMCLKMGQASEFQERLQSVLDDCFSGLTDKVSWNDGQNLEKLGHALMVLSKALPDGQDIQRYARIVISAMFSKITHVTDEELELWERAKELVDESNDESDDEDTEDTESEGVVAIRRVGTFEGMAPYETMATIGSGKRSSPRDEGDLGNPDFVVCSCDGGICNPLAGFAWWGHSVVHYCTDCSTTLLCELCYNARHDPEKVGSPAVMHFCDKRHKYIKLPVEGWQGIKDGVMRLEGEAPVKFDDFMQRLRNEVCPDAWDRYWDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS97</accession>
    <name>A0A2T4BS97_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine deaminase</fullName>
            <shortName evidence="7">ADE</shortName>
            <ecNumber evidence="7">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <shortName evidence="7">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH1</name>
        <name evidence="9" type="ORF">M440DRAFT_1100920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS97"/>
    <dbReference type="STRING" id="983965.A0A2T4BS97"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="352" mass="39459" checksum="CE09BBAC00F7746E" modified="2018-07-18" version="1">MCNDKLHQFLHDLPKCEHHVHIEGTISAELLFSLASKNGISLPADDSAFVSPTTLRARYKRFTSLDDFLHYYFIGFSVLLGVSDFEVLTYDYLSRAYSQKVYHAEIFFDPQAHTSRGVTYQTIISGLNVAKQRAERDFPKLSVEFIPCLLRHLPVASGHRMLTELLETGHFSDGTLVGFGMSSTELERHPSLYKDIYDAARAAGVANLTAHYGEEGPSDYVKDALSLLGVRRIDHGQRSAEDEELIAQLAETSTMLTLCPISNVVLKGVESMQELPIRKFLEAGVKFSINSDDPAYFGCYIQENYCAVQEAFGLSVGDWEKIARGAITGSWCSRARQEQLLKELDEVLQQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSB1</accession>
    <name>A0A2T4BSB1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1473117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSB1"/>
    <dbReference type="STRING" id="983965.A0A2T4BSB1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="535" mass="60565" checksum="407F01CE2678CCD3" modified="2018-07-18" version="1">MAENTDILIIGAGISGVGFAIPLKSDNIGGTWWTNSYPGCGCDVPSHFLPYSFALKPDWSRRFARRSEIHQYFTNIAAQYDIHKHVRLASLVEKASWDGITGMWNITILISAVGTLSVPRECTIPGASSFPGKIFHTAQWDHTFNWKDKELVVVGNGCSATQIIPEITSGPGAARMVTQFCRQAHWLAERPNPEYSAFFKWTMNWIPLAMRIYRAKLYWNQERDFAGYDIETGAEIRRGWSMGAAEYIRTNAPAHYRDFLVPKTEIGCKRRVNDTGYLACLHRNNVNLIYDDPVEAIVSNGVRTRAGKIVHADAIVLAQGFETQRPFGSLQIFGEGGVSIHDHWTQISEGVPSAYLGTCLSEFPNFFIMMGPNTLSGHLSVIYTTECQINFALRVIRPVLNAMGTGTWALTIGRPICDIVLVKRTAEQEDIDTATGCTSWFIDRSTKRNSIMFPDWQYKFWLRSVFISWDDFNYKTSQQFNEKIPELVLEVMRSAALKLRNILLQLSSNFEKRDEATTLSGYQCSSWPKRWEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSQ7</accession>
    <name>A0A2T4BSQ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1405734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BSQ7"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="130"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="331" mass="36015" checksum="7C982313619ECD97" modified="2018-07-18" version="1">MLRWGILGTSFISHTVVKSILASPNSRITAVFGRNQARLDEFAAKYDIATKYQDLDALFDDAEVDVVYVGLPSHMHASAVIAAAKKGKAILSEKSLATTMEDSHAMIAAVKEANVFFLEGLMYLCHPLMEKVASIVKSGALGNIKGMSGYYAANIWKKANPLGMGTIYNLGCYPVSLVHFIMETAYGAGAFDKRQVTGLGNLSNEGTQHARDASLNVRFDNGVLTTVQSTDSFGNDFSFSIQGDKGVLRFRTNPWLPLAGDNIIELKVYGGATEEIVVPAQMDAFGHQVKRVEDCIAQGLKEAPRPSPSWANSVEIMSLLTEWEADIKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSV5</accession>
    <name>A0A2T4BSV5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSV5"/>
    <dbReference type="STRING" id="983965.A0A2T4BSV5"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="274" mass="31082" checksum="33A015F41EE23FE2" modified="2018-07-18" version="1">MLIYEPSIARLGTLAAVFSPSRHMGIYPVVYHSLAVKGMSQCVLRNARYSELPEVAHVMAKAFWDDNLFGDLIHPHREEYPDDVDLYWLRRARVSFWNHRWHFIVAVDKDETGHDTIVGIALWARLGEGGKQPRGLHWDFRHLLKPLSSLAMTVHAWLWPNRASDTITEDIVERSYPYFSTLWADKRAESWFLDVLAVRPDFQGKGVGRKLVQWGLGKAEADGVCASVISAFGKEGFYSKCGFDEQYGSATQGEGNPLAGIKGGNIYWRGIREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSZ5</accession>
    <name>A0A2T4BSZ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1341839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSZ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BSZ5"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015373995" evidence="6">
        <location>
            <begin position="18"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="339"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="553" mass="60956" checksum="76E7A6458CEA6F2F" modified="2018-07-18" version="1">MMKALVLLAALAGCVAADDVLYSKRLLKRAMDDQGHFNMSFFHVNDIHAHLDQFVKAGTDCLDPSKGCFGGYARIKTKVNELRSAHPDHLWFSAGDEFQGTLFYSFYGGEKIAETMNELKFDAMTLGNHEWDGGDEKLGAFLKNLTFPIVSCNVKSEYPNLKDTIKNYHIFEEYGLAIIGASTPTTPTISHVGPLTTFLDPVEQVQKAIWEIRNTTDIRRIVALTHIGYDVDEQLAAQTEGLSLIIGGHSHTLLGDMDGAQGKYPTIVQDLAGNEVFVVTSFRWGEYLGEISLTFDDDGKALAYRGAPIHMDNTTELEPHLQAEVTAWRKPFEEYANEVIGTTENTLDQTNCQSGDCLLGEVMSDATFEYVYNLTADVPEDQRPVFALINAGGARATIDAGNITRGQVITSFPFGNAVTMLNYSGGDLLKILEGCVSRVNQFTNQKLSSWVQVSHNLRVTYNPSNQPGYMLVDAKISGQSIDPEKEYVIATVDFVAGGGDNILLKRDDFVVLDTLDEVLVAYIQAKTPLKNALEKRIVKVGKGTNKMQKVFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT66</accession>
    <name>A0A2T4BT66_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1313350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT66"/>
    <dbReference type="STRING" id="983965.A0A2T4BT66"/>
    <dbReference type="OrthoDB" id="3439027at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="262" mass="29266" checksum="131CB0199F635748" modified="2018-07-18" version="1" fragment="single">SSRRESWPPTQLRLVSPAMSLKKRSGLDGEPRPLLEDIDDNPLTYFLTPISADDDDDNADVDDMDLDDVDMMDFDAGIEDASQPREAVRSVSPSSLEGLRKPDCALRRPASPEYDSDALTTDDDDDEDYIRFSPSSPSSFMLSPLRDLAVEGLRFRSKSPMFGLANDTFLHYPGSLSVPAPSPSSSGRRGRGRTNSRGPTRHHMQTRSLSARVRDNHLWREPSPDVWSIEEETEEELMSDAGVDGKTAKPKKKVRFVLPEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT83</accession>
    <name>A0A2T4BT83_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_159443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT83"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="106" mass="11930" checksum="D0D98756E1A04EB6" modified="2018-07-18" version="1">MKIKLFCTETHPPPLPLSPRRSSHQTNLDKVFTKLTPVNAAKCPLPWTMAPRGQRSPALPPSSPTRETTWLCSARLLVVFLCSHLSFVRQILLVPSQDHLHQIQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTT7</accession>
    <name>A0A2T4BTT7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF74-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1383950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTT7"/>
    <dbReference type="OrthoDB" id="68104at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145_YbjQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068:SF2">
        <property type="entry name" value="UPF0145 PROTEIN SCO3412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="UPF0145 PROTEIN YBJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16679" checksum="6C17C0CD631C152E" modified="2018-07-18" version="1">MVFGRDREHKPQETAEIPNHLTDLHCFTETEGVVTTTMMDLPGYRIEQVLGTVYGITVRSRNIGASLGMVLKSMAGGELRWFTSMLYSCRNDSISRVVDECKKRGGNAIICLRFDAGDMGGFAQTAAYGTACRVVKIDENVTVPPQLQGTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTW0</accession>
    <name>A0A2T4BTW0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1341230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTW0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTW0"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015610839" evidence="3">
        <location>
            <begin position="22"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="920" mass="90175" checksum="75E689595B80DAB4" modified="2018-07-18" version="1">MQSKSLALLAALAVSAAASTAERPRIYYPHKIKRDLLGLGLGLGSNSTTSSTSSSLTTAPETTASSSTSTSSDPDLGAIISGLLGGHPSSTSTSPITSTTTTSSSSTISSSISSSLSSASESSSSSSGSVTTIVRSKTIIVTPTPEETGSTPIPFKPQRSTSSSLAEATPTGTPAGSSSAAAGSSSSSSAAASSSTPAQATSAPAATGSPSASSTGSSGLDLSLGISLPLGAKSSSTSSAASSSAASSSKASETGIVIDPTGVRFPSTTAPAAQTQSSSNAPGSSSSAIPDNSSLGNSTEADVSSTPSAQKTSSAGGLLDPILTMLNPSEATSSAGSTTSGLPVQTSLAGTGSSASAAPTQTSSPGGLLPSLSLPLTLPPILPTETSSTAAATQTSSSGGLLPSLSLPLTLPPVLPTETSSSAATTSAAATSSPQDVSNATSSEPPSTTPGLSISISLPLPPISTSDGSVANSTATVTSPPTGTATGAPTGTVTDVPVTNGTSSGEPTGVATSVSASSSAVETGSTGNSTSAVETSAPATGTSAPATSAPAATTEPVATGSPSTLVTISKPSSPVVTVPVVIQTSSAEPITSIRPTATLTNTADWLPTTIVIEPTTMAFTPVTSSASVSTSTALPTNVPKIIYPDDPNTPAAEGTVPIQIGFLYPLNYMFVASNTVAAAQIFKYLPQALATAAGIDVEKVQVAKLVPYDTRAQWGYVTTLAKINYPQNLIDKLQLDMSVANSLIYNNPDPIVRNLTALINPKINIFGQLTDGGSNNGADGNGSGSGGAPPSSGSANNDAFGTSSTDGQSSKQKATTAGIAVGAVGLGALYGGAMFIIARRYKRKKQAHRRSSSIGSSQRSSDMQFTGNGSPALMGGALMSRDMSSYGGTGIRDSHNSGTSSARTANISHPVAAENSLGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUM6</accession>
    <name>A0A2T4BUM6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1070407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUM6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="145" mass="15924" checksum="6373B590C6B01B75" modified="2018-07-18" version="1">MIKPGERRMRSNGRCAFSCLVRVVARMCAFQHVRTHVCVLVLCTCGWFMRCPHVNPTPMASLSSSLSLSFALPPARGPQHLAILLSPLTGQSPGLRSSTAVQRRRRKTVCAACSWTDPSRANVTFSEQSGGSVCPRMYRTVDSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUY9</accession>
    <name>A0A2T4BUY9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NWD NACHT-NTPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUY9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUY9"/>
    <dbReference type="OrthoDB" id="4896343at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="18979" checksum="2AF10FF34AA5F100" modified="2018-07-18" version="1">MPLRERVRRRIRGLFPREDHTSVQHGQDEAASTSVLPIETSTACVSSAPTGLAERLWDRAYDELKTSDSASALIQAYEKILSRRLSGQGFDTPVTATDQNIIAQHDTHARRTQMRQLIQDGLDKTAREARVKQAIGAAFVLSAKDMISAAIQAVPQAALAWTGLCVGLEVNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUZ1</accession>
    <name>A0A2T4BUZ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1074288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUZ1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="128" mass="14321" checksum="47AB251090112995" modified="2018-07-18" version="1">MLCVESMLAVALFHSSSIGASSIIRYHSEFHKPISPCPVLSVLACGVDAVVIPSLACFTIRVLNEPHPVFMWRRFPFPPYKSCCFTLTPWHFRQGVDAVAEIQSSGPPVTADMPRQYSPLPHSYYHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV48</accession>
    <name>A0A2T4BV48_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcipressin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1340445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV48"/>
    <dbReference type="STRING" id="983965.A0A2T4BV48"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="252" mass="27705" checksum="7EF083D431B14047" modified="2018-07-18" version="1">MDVTPSLSRSSSTSSRNKSNLSLDLSSLPPLVQPTPPSNTLIFTNLNNTDIFLPENLQTIRELIEHTAPIHSFAPLKSFRRIIVSFFDVEASLAVRQVWDGEAVMGERIKLYFGQPTPIETKPEHLALPDAGKLFFISPPASPPHGWEMRLEDAPNKQVHADDLAEALAKLHHRPVPTYDSPVTPTDGGVPNFGTRSRSSTLIYQPDAETSPGIPAVFVEDMTDEPTMSPIEVSKPIMAQTARPPVELMHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV55</accession>
    <name>A0A2T4BV55_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent protein kinase regulator pho80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1394369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV55"/>
    <dbReference type="STRING" id="983965.A0A2T4BV55"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015598008" description="Cyclin-dependent protein kinase regulator pho80" evidence="1">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20231" checksum="6F0DE537756F21F9" modified="2018-07-18" version="1">MRINALFSALCAAALVQAGFRTAQIYIQPVETPETPSLLAEVAYDPSNGAASSIISYEAPEIPESAQLVRVGLYDTKSGRWISGTTVASVDNFDKGYSPNLVLSVDAHGELLSAALKGVRIDAGQTRDFGPQIVVLPALKGKQPELNKPVVLSPEGKKVEEEEKTLLQKYWWVIGIVVFLAMSGGGSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV61</accession>
    <name>A0A2T4BV61_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1075218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV61"/>
    <dbReference type="STRING" id="983965.A0A2T4BV61"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="378" mass="40973" checksum="E017DD67AD85FD79" modified="2018-07-18" version="1">MLKTSPILSPSSASPSSFHNASRSSQGSVSSHPSQLPSMSPKPAYVRRLSSQSTTTVSATASSSALSPGRSRRTGASHSDTRTPSRASISTSPSPAALPTTTTKMTVTTTTKMGVDDETQDPGRHSPAQAQLYNALSPNKRRLAAASTTPDASSAPPAVAPASGPPQQAAIQQSAKRAKPEERPPIILPQKYEHCPVEHMVELIAHMLGELIATNDAIRISSGGLTRFHSRTPPGISVRDYLHRLARHATLIPPLLLAMVYYIDRLCALYPEFTINTLTVHRFLITAATVAAKGLSDSFWNNTTYARVGGVRVAELRLLELEFLYRVDWRIVPNPEILVAYYQGLVQRCPGYELESDGSSEIDDDDEIDDDEDEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVG0</accession>
    <name>A0A2T4BVG0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1340220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVG0"/>
    <dbReference type="STRING" id="983965.A0A2T4BVG0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015368091" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="36"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="569" mass="61201" checksum="2B9E45A3E71C8861" modified="2018-07-18" version="1">MKLLNTLPALLGFSSLAAAAPTPERIETIEARSPVSVQLASGTIVGNSLAGIDTFNGIPFADPPVGNLRLAPPRKLSKNLGTFTTPLLAPACPQLFVSTDSSNLLVKLLGSFLQLPFLQTITGQEDCLNISVQRPKGTKAGDKLPVAFWIYGGGFELGATLTYDASSLLSAAVAQGQPFIYVAVNYRVAGFGFLGGAEILRNGSANLGLLDQRMGLQWVADNIAAFGGDPDRVTIWGESAGAMSVYDQMVLYGGNATYNGKPLFRGAIMNSGTAVPAEPVDSPKAQAIYDNVVKKAGCAASPDTLACLRQVPYSKFLAAVNDAPGIFSYSSLGLSYLPRPDGVVLQDSPEALLQQGKYHAVPMIAGDQEDEGTLFAIFQNDVNTTPSLVTWLSQYMFSQATRAQLTQLVNTYDTALSSGSPFRTSFLNELYPGFKRTAAILGDLAFTLTRRLVLTEAARQNPSVPIWSYLSSYDYGTPFLGTFHASDILQVFYGLLPNNAMRSSRTYIFNFIYNLDPNVGVKGLAKWPKWTEGQQLMWFETGDANSLLKDDFRGGSYAWIANNSAALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW84</accession>
    <name>A0A2T4BW84_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SYM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1404511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW84"/>
    <dbReference type="STRING" id="983965.A0A2T4BW84"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21015" checksum="CA160036C0B78725" modified="2018-07-18" version="1">MASFFRWYNGRLAARPFLTQGVTTAVLFATGDITAQQLVEKRGIKGHDTSRTSRMALYGGCVFGPVATTWLGFLARRVRLRNARVETLARVAADQLLFAPVMIGVFLSSMATMEGKSPKERLDQTWWPALKANWVLWPAVQFVNFTFLPLQYRLLFANVISIGWNSYLSWVNSKGGSQDHELIAAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWM5</accession>
    <name>A0A2T4BWM5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1338467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWM5"/>
    <dbReference type="STRING" id="983965.A0A2T4BWM5"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="236"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB73717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="456" mass="50631" checksum="9FE0EF2C0BEF6D20" modified="2018-07-18" version="1">MSTLEELDDLDRQEKEEKRRNNGKKATVTDGDDEMKDAEEKDDILDDEILSLSTQDIQTRKRLLENDSRIMKSELSRLTHEKAAMGEKIKENQDKIANNRQLPYLVGNVVELLDLDPTAESSEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDSDQLKPGDLIGVNKDSYLVLDTLPAEYDSRVKAMEVDEKPTEQYTDVGGLDKQIEELVEAIVWPMKEAERFKKIGIKAPKGALMYGPPGTGKTLMARACAAQTEATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPAIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARAQILKIHSRKMKVDPGVNWGELARSTDEFGGAMLKAVCVEAGMIALRSGKNQIGHEHYVDAIAEVQAKKKDTVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX65</accession>
    <name>A0A2T4BX65_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_21431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX65"/>
    <dbReference type="STRING" id="983965.A0A2T4BX65"/>
    <dbReference type="OrthoDB" id="4884711at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21455" checksum="0699F1C27B7F672F" modified="2018-07-18" version="1">MASLIGQTFHSFEEAYDAIQRAEYSHGFITIKERVNRRNGVVVRGEVRCRHSGIYRQYHLSRNKYITSTRKTDCPFFFIVARRTRMADYIISARSSQHNHEPASMEDLQNKVPRPFGIQDLFQLVETRLQAEGASTSSVAREICTERPSVNITEADIFFIQRKLREGQFYASTEAFINNNKPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYB5</accession>
    <name>A0A2T4BYB5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1338079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BYB5"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="10">
        <location>
            <begin position="252"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="777"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="11">
        <location>
            <begin position="1458"/>
            <end position="1818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB74254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1824" mass="202216" checksum="7EB1F2A5B2EA9C48" modified="2018-07-18" version="1">MAPVSDSNYFPSVGQCLSGDKVLLSWKLVATALSDGTGERQKSSAIVRFFDDDYVRGLLSEPATAFAPPDEATNKSFETKTAPINVTSASTDRYDINQFKDDAKWLSNNAKVNLVTALRVVLVEYQSRPSRHLLGPLSSHDAANLQEAAGLQNGQGLAFLSDLGAAAALDADEISAEFEKPESRRRRLFDTFLTERRFFIMVADYAASIKLYRRLPIFAPGDDRIADLYKLKLSAQPRDEMEAMLPAYLDIVSSCMSGIEAGMRAFTDEEVLLNDEVELEWIRTLLTEIVHSLSVVLQLVDCYGSDFPPSSAINQWFSLMEIYGFFDSIQPIDQSTAELVMPMKVLSSAISIGLLKPARALAYLSDRDEDPAQADDVYDSYLLSPDVLEQVHKSILDAAGSDSETACPVIFTWSFLLHRLNVSYQTRTDKRDNLIQQSAREKFETRSVMRTPTGRRNSAGSIYSIESSKFDGFLENASTPRDMQVVEQLAAVATAQGRVFDIMSKMAETLGPSVDGSLSPLISSRLRAVFLELLKVSYPFVGYQSDTVSCLHALLSPGRGYWDLSASENMPVDQDILSSVLRDDLAMDFFFQQALDRFPYEFLPFITLCRILCTASQESPDERTDMILDLLLKTPTITFTLPNLFQGYELVQEDENTNSFCLLEEVPLISLSSSWSRRYIEDDAYRIPAGTYGRFITDTGRVVLMDYPHSTLALLGRRLEISLSQEGYRCELGMLQSEETAEVISLLASLLRMEQLKVTRQGGGGSGALVRFDDDLLSEASAHISGGKDIVTVVCETMDYYMQDELATAEDSAVSVLTGCVKFLHAVLQVQPSRVWSYLARAELLNSESRAGKLTKITGSLELVSERFEFLASSLSLFSALIDTVMSSAVQRRAGSKPAGRQQPETNPWLGTADKVLSQVSLSIAQTSVDVFENTSTWMFDSESRRITLLQRVVPILDKIVLYTYSMGDCPKSDNLTSCLRPAASHIIDCFLSPSSGSLRFQPLLLSFISALTKSDSTLYPKRTEAVRSQITSVLDFGTTLLRVARYLERPSTLVETYLFKTSTLSARLCAVSDHFRAPALSLLEALVVNAGQSTSEPPSLLGYLGPHISKSFLHILAAIGQPFALPSEVKTTWRFFTSILKNRQQWMSNCLLTGQTPREAMKEDAKKNEMSADSVFATALSKLKALRDLEAGEAIVVLDFVTSAQNYWPWTVFTLQKNTSYMDGLRAYVRQLKPSHQTVKSDAVLAASQARIAAYIAEIFAMQLYHSRHLGKADTLAKGLTNDLDYYLRDGVEVSSYNKSLHNNFARNFSNKFFGCSLDNFKRTVVGPRELGENYYYDLDRANEILRFDPGWQGKKGAGFMNEMKLANANLSLVDAQIALFHAWELLLLELGACFPETDATKKHMMQVAQQCLNANQVVPGPESIFMKIVDARADLALILIQRLVKSTLAVKDVNQLLETLIGTINSVEEPFEPESIAYYRTLLKALFVTLRAYQTASSKALASSQADLEGSLVTVTQTILNVLDTVVARGFRSLVSLIHDKATDVLPEDLALLTAIMQACLSVPNIEQSQTQILNIMASHDATHAATSLYSWADKLGDHGDPVYGELSILFLLELSTLPLLAEQLACDGVLGAILSANLTKFLLRTNVSPYAEAPIAQRCYGIWVKGMLPLMLNLLTSLGATVAPEITYVLNQFPHLLQASVERFEAPGASRTKEKSAQYLTLLGTSEIHSLALLTRVLAALRANNSRDIPPVEWDEAGLLENVDYWLSSRRLLKERLLPLGPREMEWRGRKLTGDCDNVLEEKVVVQLETVRDVLSEEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYX4</accession>
    <name>A0A2T4BYX4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1360328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYX4"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015748450" description="MICOS complex subunit MIC12" evidence="12">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB74464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="274" mass="30290" checksum="71A3360A76F96E5A" modified="2018-07-18" version="1">MGFATGFTGGVTLTLSLAYLSVLAHQRSREAQSQSIRTQTLMIQHLLDPVPPPLPPTRSEVAAAQREAAVEVIKQRWNSEIENAVRWVQHTDWDEVRESMEARAAYLWAKATGRSVEEVERARRALEPVKRTQAKAGGEIAAATRGAFSQAKETAEAFEMTAENRALDARLRSKKAIEQTAADAREIASVAVEKGREAARETANVIVDKAKTFVGLAGEQLEEMAGDGTKLSPVQKALNQRYQKPLPDTRTTAEILQERYIPMDKRDNTILRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYX9</accession>
    <name>A0A2T4BYX9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_363910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYX9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYX9"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="200" mass="23077" checksum="01E0CAD1B0022E22" modified="2018-07-18" version="1" fragment="single">MAGGTKRDYDGNARKKTAQQLPRGRFHSMFENIRDELDEHYDRRERVIKASRDVTAQSKKIIFTLQRVKELNKDFPEDIQQDVDTRLKEIAKLLSPIAADVQSINRYRYGYSLKCLEELVEALSFAHYLRHQKVITLEESQAATPADVMLTPHDYMYGLFDLFGELMRFATVTTAQSGKLVGDHERNILSDIQELGCSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ88</accession>
    <name>A0A2T4BZ88_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1711-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ88"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ88"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="183" mass="19021" checksum="AAFB37FDC10F81E8" modified="2018-07-18" version="1">MPPPTTKKGVKRSATAVNGNNNDGIPKPRGKPGPKKKPRLEDGTIDHSGATGRPSAHKLGPKANQGAINAGLRALDRSGKPCRRWAKGGFKLKSFTGVVWEIPRWTAPPRTVPESGAEDSAAPSAEGSNKENKENGNENENENENGNEGNSVSKSESGADVEMQSAPSIQASSPAPVPVVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZA3</accession>
    <name>A0A2T4BZA3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1393010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZA3"/>
    <dbReference type="STRING" id="983965.A0A2T4BZA3"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000495">
        <property type="entry name" value="Putative G-patch DNA repair protein (Drt111)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="338"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="56066" checksum="533BB7C8FE5FCBF8" modified="2018-07-18" version="1">MAAPPPRGLSLYDNLHDPNDPSPSATISSAPVTYKQGESAADDQAAKKPLNPALQFQPIRRPQVKQPKAKTTFLKAIPKTAPTTAASATTTPAATGAAQQPIPHQSTLADWAVTEEDEWMYGIGEKRQRGGRKKKKKRQEQFETDWDEMYDPTRPTNVDEFLKSDEKVEEVREWKALLYRHRKKHEESDLSDSEEETAPPPKQFAPPASYSFAPPPPRSPPAAPAPDETADDAYARRLALSAGQQHPPPPPPPPSPPPPQTSESSQPPAPPPPSEEPGTISKAPIRYTQPPNADDDAAPSPPPSFAQTNQDTLTPDDDPLLQQDQEQQQQQRTNRPGQAGFAHRLMTKYGWTKGAALGANESGILNPLRVQVEKRRKRADADGGGWAEPANKAKIIGGNTRHKGDASKFGPMSEVIVLRHMLDNMPDLEAEIEDGLGQEIGGECGEKYGRVERLYIDVKTRQVFIKFTDQVSALRAVNELDGRVFNGNTIIPKFYDTERFEKGLYVDATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZN8</accession>
    <name>A0A2T4BZN8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZN8"/>
    <dbReference type="STRING" id="983965.A0A2T4BZN8"/>
    <dbReference type="OrthoDB" id="4899142at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="281" mass="31091" checksum="FF415654263D5CA8" modified="2018-07-18" version="1">MGLSEFPHPFRFMWQALKSDMDKEAMGIDPDSIDQGRVYSLISKARSRIPLMEASHRVEIMPCYMPGSRMPPMFGPTVIRPEKVPLILTGLPDVQYLGLNTYVRPDSSKDERPARIQSIQRTSKYTTVALPRHVRDRLFMAPGKLFETSTGPNDVFNNTSRKRCTEPVRSGDSLAGRPHKKSRGLDVHQSDQSTPQVTAGATSPSAAGPSQAHGCSKYEEILEAWAEARHGILTLGTSRGTAAVQGSGRGSTWPLSKRKQTHCSFSWSSGHRTQLPQNCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZT8</accession>
    <name>A0A2T4BZT8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1337272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZT8"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30450" checksum="D246619060CFA6A8" modified="2018-07-18" version="1">MDDDLQFSSYSQLCIDARLYDESLIYEDAQVFGANLPYGDWFSFDINGNDTMADTPELCDSQPASQSGGSEGGSESSSPASPTSTDSFFAHQTSPALSSSYFSSYASAGTPASSAYSSPDATPGQEVASPLESPTFASSGRDYPVCCLHPGCDAKPFKRRADLDRHYKHKHAPSSQKDSYHCDYARCGRRRDPFHRRDHFRDHLRDFHKEDIEKRGVAAKEDWFEGRNASHTWWRCTKCLKRVYISRQGYECPTCKTSLQAKRKEIRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZZ7</accession>
    <name>A0A2T4BZZ7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_106632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZZ7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="208" mass="22639" checksum="8F82EA60EB67DEE5" modified="2018-07-18" version="1">MTCKECRWSGNLKPLGDGWLADDFEMMSLQGTYSGLSSHHEHCHHLSTTELSLRLNPSLACSEPTREVAVKWKSPTPNIDQCHTIAITIAITIATLQQLDRVLLSRLHGTIAHTAVHLAQAPSLSSSARSRNHRQAENHLNPPPRCASTCAFRCPQASWPRTGQPRCPSIGADMGLKPAVASTAVLLSTPRRRAKDGTSAQVLTRAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C083</accession>
    <name>A0A2T4C083_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-1,6-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1470840</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="13"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C083"/>
    <dbReference type="STRING" id="983965.A0A2T4C083"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF39">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 17 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015730653" description="glucan endo-1,6-beta-glucosidase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="102"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB74980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="429" mass="48081" checksum="CC1914339484529A" modified="2018-07-18" version="1">MRYSIVAPALLAGTAFAWLPQDRDLAAFNQTLRYEKLGKRFEPSLASGITKIRGVNFGGWLICEPWMMSNEWNNVMGCNGAASEFDCMLQHYSGNNRAAGNQKFQNHWRDWINPATVQSVHDVGLNTIRIPIGYWSYVDIVDTASEPFADGNLMLPYLDAVVQKAADLGIYVIIDLHGAPGGQQQDVFTGQNPNPAGFYNSYDYGRAEKWLSWMTNRIHTNPAYSTVGMIEVLNEPVSRHDGGNRYPAPGQDPSLVQTYYPGALKAVRDAEAALNVPSNKRLHVQFMSSKWDSGDARSNAAVKNDPMTGFDDHNYIGFALGNTGDQYSLMHSACTDSRVVSGQDFAITGEWSMTSGADWHDANFFKKFFTAQQQLYESPGMDGWIYWTWKTELNDPRWTYSYATYLNYIPTNAAALQQNVYQDVCSGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0J8</accession>
    <name>A0A2T4C0J8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1431665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0J8"/>
    <dbReference type="STRING" id="983965.A0A2T4C0J8"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="508" mass="55339" checksum="B6789B56F91763B2" modified="2018-07-18" version="1">MASPGAVDGSIVPDGQDDRTVVVKPEEQYGNSDSNSNSDAEKGQVVQDPDPLDWDNDPHNPYNWPAWKKALTIFALATMGLTISIATSISSSSVNLLEQEFGVSRTVALLPLTLYVVALGIGPVLGGPLSETIGRYPVIMGGMTIGALFTLGAGFVHNFGALCFLRFLTGFFWAPVLANAPGSLSETFMPKSRGPVSALFILTPFLGPGLGPVIGSFVSVEKGWRWTEWTMLFFSALSIGLGCTIGETFHPILKRRLAKKRGIELPPLPPMSQRVKTFAVVAAIRPVKMLFTEPIVSFICLYVAIDFGTLFSFFGGVPYTFGTVYHFTTEQSGLVFISIVIGCVIGLATIMACEILLYRKQIPKFPPHRVPPEHRLYPAMLGSFGLPLGLFWFAWTAREDVSWASPAAAIIPFAWGNLCVFVSTMQYTTDTFTGNVVASASSANSLARYGFAGVFPLFTIQMYTTLGIHWASSLLGFIALALIPIPWVLFRFGPRIRAKSKFETHKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0U4</accession>
    <name>A0A2T4C0U4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1431728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0U4"/>
    <dbReference type="STRING" id="983965.A0A2T4C0U4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB75187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="500" mass="57370" checksum="AE5F345DB9299ADF" modified="2018-07-18" version="1">MLSLEGLLFSLRPEAALVLWLVILGTVYLASIPIYNIWFHPLRKFPGPRLWAATQIPFVRMIFSGRSHQKMLELHKTYGDVVRIAPDQLAFSDGAAWQDIMGHRKRGQGENGKDPIFWKANQHSVISADRENHTRMRRTLAHGFSAHSMMEQQPLIQGYVDLLIKKLRENCADGSKPVEMTSWYNYTTFDVIGDLAFGEPFGCLENSDYHPWVSLIFDRIRVGAESTALRRLPFGERLIQLVLTKEERKRFQGHFELTQQKVNKRLALPGSRPDFMEVMTKREGDQKFSLPELWDNASLLIIAGSETTATTLSGVTFFLLTHPEALEKVKNEVRSSFTSEDEIDLLSVQKLGYMLAVLQESLRMYPPVPGAIPRRAQPGGDVICGQYVPENTVLGIWQWPMYHLTKNFTLPDSFIPERWLGDARFSSDPKDVLQAFSFGPRNCIGKNLAYAEMRLILAKIMWNFDLSLHPDSRDWMERQQAFTLWQKPDLNVFIKPRVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C199</accession>
    <name>A0A2T4C199_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1379510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C199"/>
    <dbReference type="STRING" id="983965.A0A2T4C199"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF20">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 1 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="107"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="239" mass="27191" checksum="F6C10250CED1A312" modified="2018-07-18" version="1">MPINLLSAKSLDTDVPDKPLIFVVDGRYQNWIKPIILLECLNKDYDAICLDGPATRTDWYTKIHPQRYVPAIIDSSMGKRVTSWDSSQILMYLAGKYDVEKAWSGSTVAEELEIGNWLTFETASLGPTAKYWVWYAIRKPEDKNPKAQEKMLNDLRVQYGIIEKHLSQPGQEFIGLKDRPTIADIAIYPFADDPTMARIGIDKNDFPALKAWSERFAQIPGVKKAYDEMDSRKEAVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1A7</accession>
    <name>A0A2T4C1A7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_20433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1A7"/>
    <dbReference type="STRING" id="983965.A0A2T4C1A7"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="279"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="796" mass="88019" checksum="B950E20C040E0587" modified="2018-07-18" version="1">MAIELELLSETELQSKAPAGRRFPVGCPTLDLAATWDQDDKNLLVYRPPGQIVSKIHQAAAPGEAAPEVCSISWRPDGQFLALGWSDGAVRLMGLENNKAAHQIPVCDKAEASITHIGWSTAVIATKADSAVSSKLADQVTEGWVEQGGKLPLDLPQELTFLEVETALPKISPLPMSSAGSGEDATVFTLRSGIDFLFRTPKRDTYNQVNVMIVGTSDGKLQLSIYDSFIIGTFPQPALDSVPSSPSNPAYMIHHASHPQVSTHALIFAEKQNELQELHLVPMDLPFLSFSPINLSLLSSKVTTLQALLRYLKQISLHMQVEWKNARELPARFIRSVQSDLEGMEKGPRDIVSALFHTAMTGHAYPVVQEWLVDSLAERGHKRWDKAVVSGLEGLRSLVHQHLLPALERCAIILSRLRGLALFHSDREDIGLSVPHLNRVLDVVSCLTLAGHKVLVHTMDELQHFSAFSAWLRFQIDQLAAAAAAGGTAPAANDELTEKEAMMDHTKVLTYIERYLTNSPLDIFLDDIPQDDYAKDWKTIDDGFPSSLLDVLDKQLKKHEAGQQQQQQQQQQQQQPAMKALPHVDFLVNYATTWSSRIFASVAEAKRRSVRFGAPLKLAIGPQLPISKMDVRMCSADKRTGTIFTALASHQEPHKLHLFRVKMSITNGISDTQSAETCVIDLGTRSLVDMKFLDDKTLVLFCTNKDNTPLILSIPIQDDHKLSYSTYDPANPTTQASSKTNTKAFHRYTLPTSHHALRPVRMEVHEASSVRGDLPARICLLGGNRTTWRTYALPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1P0</accession>
    <name>A0A2T4C1P0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1392835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1P0"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="359" mass="40430" checksum="DBF7CAF230DF53A4" modified="2018-07-18" version="1">MASTSDIQLASVAAGFTLGFGFLTVWKAIQHTVRNRRPWKSPYIYMVWGEIAANLILGIIGWLFLDGILGPSLPVLFFFLVLWVFEIQLLMQIIVNRIAIIAEDDNTVWRLKWGTAGVITCINIAVFCIWIPAHTEPPASELYVQINEIWDRISKILILIVDAGLNYYFLRTVKQRLVMQHGLHKYAPLVSFNAKLMVVSILMDAMLIGLMSLPNQTVYIQFHPVTYMVKLNIEMEMAELITKLAKGENADMKQPSTSGHRTQAHDDEEQERDETPHQYRMQSIHRSKPSVEDSSSIDDDMGQFDESKAASTRGILEGGIQVETVISSRTSRNSRIGNSGGMGTNRGSDDELPLSYPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3H7</accession>
    <name>A0A2T4C3H7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1246273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3H7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="17484" checksum="9E9F7E0763FD2457" modified="2018-07-18" version="1">MRSIATHVCLTSTTSSGAKGRINWCQTAGTRPAFAGIWCGPSCWFLHQWSIIELEFLSQFNLAGLFYCLTPLTRHHPLSLSFSLFAAPYWYATLHRFYYIHVPATRSRVCLCLFQHCSSADKHRATIASYTFLHPCTVCWERIPAARQQLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C464</accession>
    <name>A0A2T4C464_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-terminal binuclear Zn cluster-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1356261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C464"/>
    <dbReference type="STRING" id="983965.A0A2T4C464"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="767" mass="86077" checksum="C57E237B5A22FFB6" modified="2018-07-18" version="1">MGSSNSEEEASGSGSPLSRTRLRASHACTVCRIRKVRCDVVVTGFPCTNCRLDSANCKVMPRKRKWEQRVKRVLEQEEKERRDRSRQLVEERAKACTHINSAAAKAHAEVKPDPTRLASSTSQPMTGASTIPVYQQDNTDAHFKPPKVNFMFSDGTIDPSKIESHPSHDTSDNLTSWAPEFGTLFVPYSNYNFIDAGFLNQLSHTDVSYLAEKGCLTLPPEKVLEEFFHQYFAHIHPIIPLLSEAEFWAVDARIPLLLVRAILFIASPYVSTSTVLSLGYSSVQAAHTELYTIAKTLMQFDIHRNNVVNAQVAVMLTYHSPTTSDTTNTYWMVNAIHYARCARADQYHILSDDNPRKPHLKRLWWGCILRDRILSLSLRRPLNIGCDEFDFSLPGLSLADFADEIEVSTVYDRPTKQILAHMMAAFCELIIPLNKALTILHPAAGPKTVASETDIQKDTDACVETLQLLDVWYQKTRERFEISTPSIGVHKSLTMFTKMTFIYYYSARASLCYHMMLLSVSNPSHASDQKHDLQIQAEMDSALKGITGIFMHLARLGVVQYLPNTFVALSAIPLIWQVLDAKILNTGTLAADNKRDLMVYTSVMNKFRSLHENADNVLKFIKQIIAHIQTTESVDMAQPDSLLSAPTAPSETYFPPELLSNFAQGGKPQQQQQQQETDSIKNKGGVDGYPGGGPQSKWAKLFAGNPRTYLRIALTIQHSLSSGHFPSEEDFPKALQMVKFAEETMDNGIDVGLYKYLQHMEDFLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4H4</accession>
    <name>A0A2T4C4H4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1333848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4H4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4H4"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08296">
        <property type="entry name" value="CAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="11"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="340" mass="35868" checksum="047F41B0F5182808" modified="2018-07-18" version="1">MSLPKTYKAMVTLEANAPFTQQELPLQLPGPNQVLVKVLACGVCSSDVSIISGHVGPVFPRVTGHELVGDVVAVGDNVTRITVGQRVGGPWHGGHDGTCRQCQRAQFQYCANQAVNGVSFDGGYAEYVLLRAEAVVRVPKEVDAAEIAPLLCAGVTAFNGIRKLHVEQGGIVVVNGLGGLGHLAVQYANKMGYEVIALSSGDDKAGFAKDLGAHHYINTKASDAVAEILKLGGADIIVQTAPDVEMMSALVEALAPGGKLLNLCLIGPVPFDTTALVRKGASVHGWASGHAIDSEEAVHFAVRHGIRCMIQRYPLAEAQKAVDDLIAGKPRFRNVLVMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4R9</accession>
    <name>A0A2T4C4R9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1377810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4R9"/>
    <dbReference type="STRING" id="983965.A0A2T4C4R9"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="471" mass="53147" checksum="3D355C124704445C" modified="2018-07-18" version="1">MPPTSPASHFLVRKIAIIGAGPSGLSAAKYLRAQNAFDSIVIYEQQREIGGIWNCSNDLLGASLVSKNENLDSSPSRISGEPSILPSPLYHQLYANIPLPLMQFSDQPFPPGTVLFPPIHVVRDYLLKYAEDVRDLIQFGVQVGKVTPLSEGEETTWALEATSMHDNRVIKDTYDAVVVATGHYSQPFIPDLENLREFREAYPSIVSHSCDYRSPMPFRDKKTIVVGNGPSGIDIAFQINRLSPGKTILSVRTPTPPPRLAYVGCTEVPEIGEFLVNERGIRFEDGRVEKDIDTVIFCTGYRYDYPFLPDLRPKLVTTGHGVHGLYKHIFCIDHPTLAFSALNMKTAPWPLSEAQAAVFAAVWSNSIQLPSTEEMRSWAKALYEDQGERLQLFRNPSADGLYINGLYEWVKKSAHRGKEPPFWNDVTYWYKATFHQVRLKYELDGCKATELEELGFRYESNWREKQTPSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5C5</accession>
    <name>A0A2T4C5C5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1233188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5C5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17541" checksum="C7CC889721F474C0" modified="2018-07-18" version="1">MCIFWAASEAVERGALAQTAVAHFVTHQKLPPNPETPRFALLLKRYGRVLLKEIPIQMRYQCLLSSPTCRGGCVRCRFDHGEQAGGNSTWPLPAYRCMSCVSHVSCLSLVGCLSMSLLFPCCLMLLPGSHCRSCQCMSGLRSIQRDAVCRDVFCHENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6C7</accession>
    <name>A0A2T4C6C7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1355578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6C7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6C7"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015730659" description="Concanavalin A-like lectin/glucanase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="26618" checksum="80B83C27EF283147" modified="2018-07-18" version="1">MMFIAGVALSALLCADAVFAGVAQDRGLAARLARRAGRRSAPFRNNTSHATVQSNWGGAILEGSGFTAASATVNVPRGGGGSNAAGSAWVGIDGATCDTAILQTGFDWYGDGTYDAWYEWYPEFAADFSGIDIRQGDQIAMSVVATSLTGGSATLENLSTGQKVTQNFNRVTAGSLCETSAEFIIEDFEECSSNGSNCQPVPFASFSPAITFSSATATRSGRSVSLSGAEISEVIVNNQDLTRCSVSGSSTLTCSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Q7</accession>
    <name>A0A2T4C6Q7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1400141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Q7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Q7"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="81"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB77235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="390" mass="43572" checksum="9D4106E116FD2A72" modified="2018-07-18" version="1">MDTPQEEAQTATTTAASAPSTAPANPPMSKNALKRLRKQEEWEAGKDDRRKRRKEKRHERKTRARSERAALIAQGVDPQELQKKKTPSTLVPVGIVIDCDFEEYMMDKERVSLSSQVTRAYSDNKQARYRAHLWVAGFNKGIAKRFNEVLGAQHKKWKGIWFDDGDFLSCAAKVRERMNAADGSGGEMIESLQRSLDEAPAWTRDETDPFPLPDPEPPLDEANKDVVYLSSDSPYTLERLEPNTCYIVGGLVDKNREKGLCYRRAREKGIRTAKLPIGQFMVMQSRQVLATNHVVEIMLKWLECGDWGQAFLSVIPKRKGGRLRGEENGEDAGEGEGEGEADEEGEEQDEAGDEGEEAEASESKERNVPQAEAATDVGDASKAEQVEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C706</accession>
    <name>A0A2T4C706_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1400224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C706"/>
    <dbReference type="STRING" id="983965.A0A2T4C706"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="737" mass="81255" checksum="432A008359F2415B" modified="2018-07-18" version="1">MADNPIEQGDRRPGITVNHIPLHLQRDSRIKDSLNDKPLAASQSGNESQSLSVTFGQRKHFPESLHFSPNTFRLRSRTASTRSSISSANVPDSATTYSHSTLASPISTSYASDLSDIFCGHLADASRPASRVFHRHRSSTGSCSTHVNDDDDAFSFAGYPDLSAKLGEIHVATPVTPVPVGEGDCLKQSTSSSKVSPIKEEEESPTPEDSHEWPQLETSTIEASTSSRWDTASSTSDDVSSQDTEAILDYTLQLVFGIDLQEEASKVTPAVRSLVCKFVGDVGSCFWTAPSDADVTQAMSTSSSSSTPSQGGSGAGDSQSGGKRKKQGRADEEDGEFSDGDGLGYNPTKKIRPNPKDEENLRLSCPYRKRNPTRFNVRDHHSCAMTYFPKFAELRQHIVKQHKRDDPSAFVCDRCNRDFHTRKELRDHQRLPKEMMCDILDHDPESGVDGTTSIKLLSRKRVSGASPEAQWKEIWNILFPDDEDHQIHPYHFTPVIEHFELSNYYMSSFEVLHSSLRDKISNPQTLETLTTKFHQCFIEAVERCIGAAQSMPYTNRSNKRNEPPRAQNFQTMIPRKGRDILPRPDSGVVMMSDECSEESNSLRNSALGGPRDSVRTVIKGDARRRGSNLAPDPSAMPTPAAVGMMDHSFSSHMSFMPSMGVSGPMNSVAVQSWNSNVAGPNDGDIGNSFPMTDHFYAPGELTPHGDLGNWDEGYYQSFQGLGDRFHGFGGGRTDGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C724</accession>
    <name>A0A2T4C724_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_3567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C724"/>
    <dbReference type="STRING" id="983965.A0A2T4C724"/>
    <dbReference type="OrthoDB" id="5323870at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="78284" checksum="B9F00B81BBDC131B" modified="2018-07-18" version="1">MGPTTTPRIRRTAQNTQFTYNLSRRVNDVQTYPIQSPQGATILIYGHDNGISLVWRGGRRFKHSKEAQKQQQQQQQQTDKKEQKNGAADDVVMIIDSDDDEPAKAQAPQGYVDKPEFEDTVEKTPYPDIVQTLDLAFGTAVLKVAVMPLVPCSSAEAGSNGEPILAEKMVFAVSCATNDAYLVTLPLTPPSPESKARLELRADLLAGKAGSGAWGESLTLLGGQTKHSEGLAITIVTPKSADSSGKAPRAVVAAFSRQASGTLHLWEIALDSKPPAQRPVEPFQSEYLPAPLTSISFNPTHTTQLLAVSSPHAVRIYDFAQSVLAPEPDARGPFPSQGSWLLSLYQPFVKTSSSRKPILDAAWIAHGRAVFALLADGMWGIWDIEGAKPLQSGAALSNKLKSGVQGAALTAFSVSGYVEGTGSLRSVATQQKDKHAGEFAPMTPHTRKQAAASLTGTPGVDRLFAVHGGVKVMGLPYTPGKALQDESLALWIGGLEHVCVIPGVLRFWDSQLRRGSGGGVNLFSGAQPTRMLKLVDLTTGLLGERCCGVGLIPDSSKNDEDVPDDGGLPVDVLIRGESRIVIVREGEDGPGRKIGDVVASRRKRLFSRTDKEAIIVHGKQDRPASLSFNLSTVKPGTLRLKPSPKDEPDGNEIGNGNGAGDKMEDAPTPTSRSRAGFGFADTLSAAADVSADFTTRDVEAEMLDIMEIDQALNNLEDYRGSGRKKVLFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7U8</accession>
    <name>A0A2T4C7U8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1330554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C7U8"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1451"/>
            <end position="1460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1489" mass="167494" checksum="EFA9DB64896D18B4" modified="2018-07-18" version="1">MLRQSSRLTRQIPQSLPSRLRLDRGNTRLVLCRPRFSTQAARQQSDASRDSLLKKMGESAATTFASIVVLALGFAAAGFIYHKSYKMIVLKKMTRAFEPGDPVLDLATTAKEVPRTLVPEDEHWVQRPEQAHVDRIIDGRESGHYYLFMGEKGTGKSSMLIEAMRKTDGDGVAMFEAHADTEIVRIRLGKALDYEFHEDYIGGYFSERGPRETTALLDIERALNKLEKVAMKLAKTRRKPIVLIVNQLHLLRNNEEGRDLLELFQQRAEQWAAANLVTMVFNTDDYWVYERLKLLATRMEVLAVTDLPKSQAINALRKYRMRYFHEIPNHKELEDVYDRIGGRLSFLNRVAKSRDMIRTCDQIKDTEKKWFLNQCWILGSEMDDDVMDQQKWAAAAMTLALALVDKEEEKAESYDSVVGHLLPTFPFHIAQEIMTRADFIRDLDSLNLFTVTSQADVRASSVPMHLAFKEICAEPRFRKHLEDTVQRIADIESLGRTRELVAKDLVLGGQYDIETSRKGITKRKDEKEGDEEKREDKIGKTRCFEFPHLSAPALMPANAKWPDFQLASKLRKFIGSSAPDSTASDPMSSQAKREELQSSQDFDDEREGEARTATMAELDDDPIEEMEDVDDYADEGDASAVDVDFGDLEMFDSASQLPFSSQAPQATKYDEPELPTLTESTPRDKNTKKKAKDGRRSASDFTHPDEATTAPAAEDDKQGSDAVEHATTDMDGLDLTPALATQQKKKKRKQSDSVDGKRHKKRKGVENGDSTVIQQTQDEAAESADNGDAETATSTNFLHLNKHATSQRVDTAIEDDSANGEGQISPSLARARRRSQTGEETRSRENSVSSRAQVAPMAPMAIDTLPQEEEATPIDRDVEDLAREAWREHISSQAGSHVKASGDSAQAEEQPPASPAPRRSARAKKAPVTLAQAVDAKVETPAKKNRRALEELPSPSANSPAPRARAKRATKRQPRTLQSLEENGENGEDDEPPTRRSQAGNYTQGRFTDAELEGISRAVEAFRNEYGMTQTEVNEIIQAPGGTAAGDAHARLWYRLFEVCPDRKRQKVINIARKKFHNFVARGTWTPEQDAELASLIEVHKTAWSKIAGIINRHPEDVRDRYRNYIVCGANQRKDVWSEEEEAHLSEIVRNAMTAIDELRVAQPDKPLLKKAYEELIDWQDISEQMGRTRSRLQCITKWKAMQMRLSGKKKEKKSGTSQDLAFQLDVARQQLASMREEEQYRLVLAIQGASALTEDQIPWTKLLDKKFRRQWTRGTQALLWDRLKQTVTDWESMTVLDIAQQLINEYNRTGSLPEVTGSGYDDDDREKDILRQLNARNKPAPAPKSEEFVHDSGAEEDAKKDDQPAQNDKPEITIDPALMEAAPPSPPKATPKPKKAAPKKTQAKKKSKKQDLSQDPIEDSEPTLPVLAIDQGEESNLEEAQTRKVKTPSKFKSVNSGSDENGVDAPQTDPYSDSVMDDMEDLPARIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C808</accession>
    <name>A0A2T4C808_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1421468</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C808"/>
    <dbReference type="STRING" id="983965.A0A2T4C808"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="514"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB77717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="656" mass="72035" checksum="A7A3335E05948B8B" modified="2018-07-18" version="1">MFRAAAAGPFDEVVTKATDENLTSEDWGAIIEVCDKVSGDPNGSKEAVQSMIKRLAHRNANVQLYTLELAHALCQNCGKQMHREIASRAFTEALLKLANDRNTHQQVKSKILEKMHEWSDMFSSDADLGIMNDAFHRLKQSNPSLHPPSAPRKQGLTDQDRQKEDDELQMALRLSLQDEERKKPAQATPASQASSSSQQPQQQQTTPGSTAVPSGTTAATVSRVRALFDFVPTEPGELEFKKGDVIAVLESVYKDWWRGSLRGKTGIFPLNYVEKLTDPTPEEMQREAQMEAEVFAEIKNVEKLLTLLSASNTGPREEDNEEISKLYHQTLAIRPKLIKLIEKYSQKKDDFTQLNEKFIKARRDYEALLESSMSHPPQHNYQQYAMRPAQAYPPPGGNYPPQPQPQDPQRFYTPGPQGRPQFQQTSSPPPNFPQSGVPPQASSHPPPAPFYVAGTEVPTHAAPGQPHASQQQQYPPSDHGPRISANGSQPPPLNTSASPSQNFNPFKQPPNQGPPSTHGAQELATSVYDSPIAPNNPTSAATFSSSVYSQEGPGMPHPKDNEPIAPYNAQQPAYQSYQPPQQNPSAPPNQASQRPPNVMSPPPPLQPSGAAYDARQGLPSQSAGGSGQQYRPYVPPGSSEPSAPAPNDYYRQSGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8X6</accession>
    <name>A0A2T4C8X6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1328958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8X6"/>
    <dbReference type="STRING" id="983965.A0A2T4C8X6"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="448" mass="50448" checksum="B4F440D7851FD59B" modified="2018-07-18" version="1">MSDNCLLINKAEKAIYVVDLNLQAVRTCLREKEGRVVCPGIWTISVDTGERDRFNENRLVEFLLLTRRFTVSIHGVIEQAADDLAAGDDRGAKRQKLDDGKMKSRKVQATDPSRKQTEHLSIAESRPTLPAPRQVVNRAVVPLLDLRDGETALIQAPEVNLTDQMGSYRLQRIQEISDRQAAGVFSCQRSGISETLVAKILCCQNHPRLLDLRRLMELWMQEKTMLEGLEHKNIVSLKGVDARFFAIYLECLPSSLRRGPQSPSIGRSDAWRILHDISSALTYLARRGIVHHDIKPQNITYSVDRGAVLIDFGMAASVTNTDEQGGTPHFVPPEYLIKDKRSRGLAGDVWALGVTMLCILRKLPRNVFKRHIFLWELLDEKSQSFAAFGDLLQDIASARKQLDLEDMLEKLVFQMLDPDRERRISATAIELALKDSRALTEGNDDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C960</accession>
    <name>A0A2T4C960_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal targeting signal receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1429197</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C960"/>
    <dbReference type="STRING" id="983965.A0A2T4C960"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB78116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="652" mass="72334" checksum="8C75C71C7C669189" modified="2018-07-18" version="1">MSFMGGAECSTAGNPLSQFQKHVQDDKTLQRDRLVGRGPGGQLGGFRSSPANAPQDEMVNGFLNAGPGLQQEFPTLQGAPGIQLGPAPVANSMAPQWAQDFNAQGGMELMHQAPPRALFSPEEFARFQQANPAAAAAMAPEMRGEMPAAMPQQRPMMGMGMGMMGMPMGYGMANQSMMQPMYQQQQQQQQPVQQQQQDLKGKGKMVELDDSKWEEHFAQLELQDKEEAKEAEKEANAAERELNAMDNKLQSETNEFGDFESIWKGIQAETAAARSMANEQQYFDQFDTEWGQDLMPDFNGVNDWGRFADPIVEKYMFEQENIFRDQKNAFEEGVRVMKEGGNLSLAALAFEAAVQQNPEHVEAWVYLGSAQAQNEKETAAIRALEQALKLDPNNLDAMMGLAVSYTNEGYDSTAYRTLERWLSVKYPNILDPTNLHPVADMGFTDRQQLHDKVTNLFIKAAQLSPDGEHMDPDVQVGLGVLFYGAEEYDKAVDCFQSALHSSELGTTNQQEQLHLLWNRLGATLANSGRSEEAIAAYEQALSLAPNFVRARYNLGVSCININCHQEAASHFLAALDMHKTIEKSGRSKAYEILGDGAAGQVDQALDRMSAQNRSSTLYDTLRRVFTQMGRKDLADKTVPGVDPDIFRPEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9X8</accession>
    <name>A0A2T4C9X8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1461496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9X8"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015442792" evidence="1">
        <location>
            <begin position="22"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="59841" checksum="CC229A5EDFAA32D5" modified="2018-07-18" version="1">MSRFRCLFGLLVLGLNPLTSGAPLPRDEEQTTPKLVLHEENEIAAGNSSLHEMNDYERSSPAADPQHIDETYLSLINSSPYIWSKVHIHQYQMPQWEQDMPQFIYPGESVSILIQPTHGAGNWADSAAEVEYALRGTSEPMSFMVKFNNRGSSTLKIEYHDGLSSINNAKGSVHNLGINRWPGGSAFILAGKEGEFITNDPPIGWMQRLLPQLEKKPLREIILPRSHHSGLWGHFKKVGLATPANAQTQTVQLNDQLGDGGIRVLDFRPLRTKEGYREIHGTRILDLFHGVMGTSLKDMIQIVNDFNRQNPGELIIWDVHSSDGWNAERDYHPLDQADRVALYEEFKALENRIHVLGEGWDLSQLELGEFIGNKTSAVIVNFDDRWRQMDGDLFPGSTEGYITGAILPVRHPWTNTDQIDHMVKHQVDEYRKNRPVPQSPIHIMEWLLTQQGIGAAIPIRPITELALSAWRTLFHELWTSTTSNSYPNWISVDNVRGNQLKALVMAMNHCLVAKQCGDLGGKVTLDETSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Z0</accession>
    <name>A0A2T4C9Z0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1372832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Z0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="36000" checksum="16D46D7696927C84" modified="2018-07-18" version="1">MSLPSLKQYHRKPYEAISPSRPELSQAGRTVLVTGGNSGIGYAIARNFIKAGAKRVIILGRRPDVVKAAAKKLAQEANDSGSSTVADGRICDIASLESTEALWSGLQKDGIYVDVLVLNAAAAGRVAPILESGLKNVWADYETNVRSSLDFAERFYKQNGKGADARKFLIYVSSIVSYMWSTMAPERPSYGLTKNAGTALVQQIAKDTPVNEMQVVSFHPGGVLTDMARAAGAREDIGIPFDDENLPGQFAVWAASREAEHLHGRFVWANWDVDEVKAVLGKQIAEEPNFLKVGIEGLSENLPNPMIPPEMLEKILQFQKSLQSNLQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA22</accession>
    <name>A0A2T4CA22_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1399518</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA22"/>
    <dbReference type="STRING" id="983965.A0A2T4CA22"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB78362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="381" mass="40439" checksum="004904B1FD2B4DDE" modified="2018-07-18" version="1">MAETAGKTITCKAAVAWEAGKELSIEDVEVAPPKAHEVRVQIYYTGVCHTDAYTLSGKDPEGDFPVILGHEGAGIVESVGEGVTNVKPGDHVVALYTPECKECKFCKSGKTNLCGKIRATQGKGVMPDGTSRFKCKGKDILHFMGTSTFSQYTVLADISVVAVQPEAPLDRTCLLGCGITTGYGAARVTANVEEGSNVAVFGAGCVGLSVVQGAVVQKAGKIIVVDVNPSKEEWAKKFGATDFVNPNDLKGQTIVEKLIEMTDGGCDYTFDCTGNVQVMRAALEACHKGWGQSIIIGVAAAGQEISTRPFQLVTGRVWKGCAFGGIKGRSQLPGLVSDYMKGALKVDEFITHRNTLGEINSAFETMKQGDCIRAVVDMRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA62</accession>
    <name>A0A2T4CA62_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1420543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA62"/>
    <dbReference type="STRING" id="983965.A0A2T4CA62"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="1">
        <location>
            <begin position="276"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="612" mass="69177" checksum="25F80D350084E8E2" modified="2018-07-18" version="1">MAIQRSVANASSVAIRIGALLFFRAFPARLPSIIFALFAIYIPAFLTSFFAPPELEVVDDEVDITVKETIVTPDDEPDQELVADEVDVKETISFSERDVPAWKIIFYGAPSAKRPLSSLVSFLINLVFVALTADALYRARWYYPADDLSFVRLGYVSHNSANFLIREPDQAKMPVTFQIRHYNGLIWQSVGSVKATTNETDFTSVLTIPLSSYTEQQKYEWRTSNNHTGELTAAPQPGKMPTQNGGKYTFLSTSCILPRFPYSPFDHPLAIPGLRNLAKRLPELSAQFMLFLGDFIYVDVPERFGKSVDEYRMQYRQVYASPDWAPVGQNLSWIHVLDDHEIANDWDANSTGVYENAVDPWHIYQAQVNPPRAVAAGTTSERRQGATWFEFVQGPASFFMLDTRSYRSSNSLPFNATEKTMLGADQLADFLAWLARPEPKGVRWKFVASSIPFTKNWPVNVKDTWGGFLVERKKILEAMWNVAARGIGVVILSGDRHEFAATKFPPPPESEWPEESTVYEFSTSPLNQFASPIPSYSQVDDEDVLIQYHHSGMSKFGSFTIQEEDGESKLLYRLFISGDEKWNTTITAPPVPPEEERKHASSGSFWDRLRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAV1</accession>
    <name>A0A2T4CAV1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1468998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAV1"/>
    <dbReference type="STRING" id="983965.A0A2T4CAV1"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="658"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="866"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="989" mass="112004" checksum="E4E246F15FE72A33" modified="2018-07-18" version="1">MDTPRQGQADAGSVSSEGITRGTARDTGRENDGGAPRYVIPPRELTAVEIPAVVEDIDRAVRAFGRAPSLRHVLDPLRNSIPLYIDPEEPFCPPIMSHNARSHNVVLKVTVPKRTGRKRKRGTDGPWQGDVELQGTDTSASASENVQSVARHDDPRLLRRKLEDNVGRYHVEAVGLIKHTHRFRGLADFYWDMDKSSFARRYVDQVLPGDVDKIKQFKFTPGIDQGPNVDIIPPPIFTHMSLPFNYFYSQNPYVRWTEDGGTVNTTAVKQVGHFIGTEDAAPTGPQIPPDMTDPRMVEVIAQLEEAFEDRPVWTRRSLLNHLAGKLRNWNELKKYLNYTAYQFKGGPWRDGVVPYGIDPRTDPKYRIYQTLMFKLPKQKRAKKDQTWQSLRRVQMGRTKEFVQELSASHIFDGETYHTDGKVWQVCDITDPLLRELLDNAEVRPTWDVSSGWYHGGLWAKVKAIMKTKLVAIQFGRRLTKEDFAPTLQCGDQTPIRSTSATFHLPLPNLHLTKEELTLLRGREPSKKKKSQVYNVRVRPRAKMGVDTEEQSSVAPNDAEVEADADPDPDPDAEVDSEDSEAGSDDDEEDEDGDDEDEGENEHGSDEEEEMGNTGFGEDEEAEASGPWFCKHCNKPFAVYEDLIKHKRYMRNENKENHIHCKLCGRDFHTLEGEMKHMQVEHPLEQNLECPGCGQGPFKRLGALIDHIERGFCTRIDTSVLDKLREEKLEFPRRLQELTKEPVKGNYTKYMPSTTAGSTISGWNMDKEPTSFKLIEEEFPGLSDTEEGGAQLTETTSWSKSKPRTGGGNGNVEAQPVLRPPFRPAKQTARPSFRPGVTTITAGMDPDDPDCPSFNAARYYCMYTDKYNCPKRLCGKTFKSAKGLVGHLRSPVHGNKSYRCPYCLRIFKTLAGIASHAESRSSRCRIQDTEHYETFMDQLTAGLVDVERTRYQDGSIIFKTSEQVKQKLRGETTVDKTKYPVTTVPDDVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBM6</accession>
    <name>A0A2T4CBM6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_224768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBM6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="149" mass="16688" checksum="D0B0E7D45A6E7018" modified="2018-07-18" version="1">MYCGNPPWPPTADTTHAIHLFPKRPGSDELSMAVDLLGVAPRNSQAPRDQRRPGSVSSVASPLVWTDFTPCLELRFDIYLMLPTLGRGSLTRITTFTTFLQRTIFLSAANSILFFLFPFWIFKIPGPSHLSYLPGALDILKPLTIQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBM9</accession>
    <name>A0A2T4CBM9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1157199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBM9"/>
    <dbReference type="OrthoDB" id="10612700at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015406124" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17532" checksum="73BAA542B53C00B0" modified="2018-07-18" version="1">MVAIRTTALLPWLMMASFCCFVPASQQSLDDAFSLDSILKALPMLSPTTITLLHAKSTATISTENKCLGAVSQPTAESRHTHRIASHRIASHRQETAAKQLGCRQSSRRGHWQVLAYITEQHSHRHRLSKWNSSVALARSQQVSSPSSQSGSVLVPSPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBZ1</accession>
    <name>A0A2T4CBZ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1389137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBZ1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="494" mass="55099" checksum="781915E5A6B84216" modified="2018-07-18" version="1">MAVLDEKHSGSGRPSTDVRDTEVAIAAEEVVCPAHTTERRLMTKIDMRVVPFLCIMYLLAFLDRVNIANAKLFGLAKDLDLGTGDKYNTALVIFFVPYCIFEVPSNMLLKKFKPHVWLSLNMFLFGFTTMMQGLVKNYSGLLATRFFLGLFETGMFPGAFYLIGMWYKRSEAQRRYSFFFNSTTLAGAFGGLLAAAIGKMDGMRGYSGWRWIFLIEGGLTVFVSFFFFFLLPDFPEEAKWLKEDERTYVAARLRVDQGTGSGAARSMTVKDALNVFKDWKIIAGGFMYFGLIVPAYGYAYFAPTIISTFHYSPVETQLRSVPPWAAAFGFSLLIATLSDRLRHRFAFAIASMLIAIAGFAILLAEHSNTHVQYGALFLITSGAYTAMPIIVCWFNMNLGNHTRRAVGSAWQVGYGNLGGIIAVFIFLTKDAPTFTTGYSVCLAFTVLSMVSSALYGFGCMMANKRRDSMTDVPELSEDEKTALGDLSPDYRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBZ9</accession>
    <name>A0A2T4CBZ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBZ9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="15311" checksum="771AC04F3E572052" modified="2018-07-18" version="1">MLRKRIAATNTIQEVHAITPRQSTNLCHSINQLELPSSQSPVTRALIPNTHGLGAQTHPSYPPRQPPQNGRANERRGLPKDSRRKRSPLYLLYIACSCKFVCNTCISSKLLIHIVCVFFCSSSHTSSLGISNKRFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC53</accession>
    <name>A0A2T4CC53_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RmlC-like cupin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1436498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC53"/>
    <dbReference type="STRING" id="983965.A0A2T4CC53"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33352" checksum="5BCBD64429D4C20F" modified="2018-07-18" version="1">MSVPRAIAKVVRAIEQAEGAGARVRRSIGTREQRNFSPFLMLDHFSTTAGFPDHPHRGQETITYLLDGVIDHEDFAGNAGTLHSGDLQFMTAGRGIIHAEMPRKQPDGRPNVGLQLWVDLPKELKYCEPRYRDLRAAEIPTVDVDDGRVTVKVISGQSHGVDSVKELAYTPVWLLDFLLRPGAKVTQELPKGWNAFAYVLDGSVVVGEGPDARKVEQYDNVFFKQEGDVIHLSTDGNATKDARVFVIAGTPLDQKVVQYGPFVVNSEEEVMQTFSDFQSHENGFERAKNWRSKIGNRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC68</accession>
    <name>A0A2T4CC68_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1398418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC68"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="82" mass="7970" checksum="FE67F508B95E17E2" modified="2018-07-18" version="1">MFPAVVLVPPKTVCLSVSSPGAAGSAACCVQSTTGPLGIQAPTAAPTAASLHEGDKGLAQGSGVPARMQIELLPEPITAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCQ1</accession>
    <name>A0A2T4CCQ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_235133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCQ1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="13314" checksum="A6B3FBF1E942BADB" modified="2018-07-18" version="1">MGRGRWGITASLEQGGDAGVWTKLLVFLSLPMEVEGALLFDPLSLGLFLWVLYSLRVMFSNMRLVADNLIRPFSEEGVTVTRLVIPNCLKVTFCLIRNRELNKASIAIVFGQPAIFQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCV5</accession>
    <name>A0A2T4CCV5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARF/SAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1428742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCV5"/>
    <dbReference type="STRING" id="983965.A0A2T4CCV5"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="181" mass="19965" checksum="FFE407A2CFE66E31" modified="2018-07-18" version="1">MGAGMSWLTNLVWAKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVTYKNLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVVDSTDIDRLQTAAEELSAMLNEEELKDAALLVFANKQDQPGAKGAGEISEALQLGELRDRNWSIMACSAVDGSGVNEGMDWLVQTVNQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCX2</accession>
    <name>A0A2T4CCX2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1468252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CCX2"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="278"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="637"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1486"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1609"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1207"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1504"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1647"/>
            <end position="1660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1660" mass="181950" checksum="5B79DB5205100ACD" modified="2018-07-18" version="1">MSGGPASALSTPRRRSAACCVSVCSRYKYTAILHRLSRQPAPAVFPPELPGQLTVKTSSSKKRKLARPLTIDFDAPTSPSPDTAIPSCEPDDDAAALSFSATPTASGLEAPLYVRAGSVTASSVPPRLQTQAQAQIASSLVSADYASSVASSPGTSFYPEPSIDSERGGDDASSVRTYARSQSPFLISRKALMNGDADLPQRSSSPLKRRASSMDPETLPDKNGDAAAASAGDVEMASSSHSSAELPRAMSVDVEAQDSKPSANHGAGDAAAQSAPPPPLIEQVKIIEMLLKASAEKLPQEGDQTYIVSRTWVDKALSLRSGKADEAEVSLGPVDNSDIIEEVIQEPGREDFVRLKPGLDQQSFELFPEDAWKLVMDWYGMVEGQKPIVRTAINTAVDAQSPTEIVYELHPPIFRVHRLWSVLSPLPIEQTLKAENPPPLALVRSRKSHAQTFIKDIKRLSGIPIDRKVRLWLVNTELLEATQAPVKATDPAPAKSTALLTTPPDSPGREEDSNGAAESGWSHLLLDVATFGSSRDARRLATLEDHTVNPNYNGSASIQLFDLVTDQTLIVDELVSKQLWVSTCTSRSLVEKAIPTRTNDTALIKPLNNRTSPSSSEGPTTRGRMQKKRNGRSVGAVGLHNLGNTCYMNSALQCVRSVEELTKYFLTDAYTSELNKTNPLGYNGKVAMAYGSLLKEIYDEGRGSVSPRDFKNTVGRCRSTFAGWGQQDSQEFLGFLLDALQEDLSRIKKKPYIEKPDSTDDMINNPEAIKEMADKVWDITRKRDDSVIADLFTGMYKSTLKCPECGKISITFDPFNNLTLPLPVENMWSKTVKFFPLNDVPVMFEVELPKHSSIEALKSFLSIRTGVPPNRLMGAEEFKDRFFKIYDNSGDVSEEIGANDVATFHELEAVPTNWPAKGYQKKPRSMLDLDDAPAEATEEWNDPKYDTMVVPVLHRRPFATGKVPEGTSPPHFITLTREEASSYDMIKRKVLERVATFSTWSKLREQQNAEGSEADMVITTASDADSSGDGKVVANSVEGEDDMVDVTMKDASSNASADAAAMPPPELPLPNQPQLLRRFNSQRPKFVQPGEFLDPELQGLFELSYFANRTDGTVPTGWTNVDNNKTLPKLADRIPEAQKEEEDQPSPESWNSTASGNEESSNEEENPQQESSQTRMADEFSEEDVPHDARTLARTGANRPQKPGAGGRKKFKNHKTYGKKGNKRRDKQMRAGKHVQRSPVVESEPTPPAVADGGPLIRLYEGLVVDWSEEAWETVFGYTGKKQDASQGAKSFVDLETINDPALKISQRKRQSRRSRGITLDECLDEFERAEVLSEQDMWYCPRCKEHRRASKKFDLWKSPDYLVAHLKRFSSSGWRRDKLDVLVDFPIEGLDLTSRVIQKEEGKEEIYDLIAVDDHYGGLGGGHYTAYAKNFVDGRWYNYNDSSVSAVSDPSSVVTSAAYLLFYRRRTSGHLGGPRFAKIFEKYNTDTSGDDEGESDDGLGRTVGSSSGAPRTTIKSLSDSQDAELPPYEEAIRSIEDESLGASGSYQIAGPKFDMTQSWSFNNLDGSGAEGSTAADYASDDAQFDSSADERGPSREDLFEADTHMTSAGSVNGFANEEAPSPAGAHEEVLTVPTVPSGGEDEDEVAEIRIEGDNAARTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCZ9</accession>
    <name>A0A2T4CCZ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1398687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCZ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CCZ9"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="352" mass="39955" checksum="4B6A02166E5AA9EA" modified="2018-07-18" version="1">MALIVDKHRPRSLETLSYHHELSERLQSLAQSGDFPHLLVYGPSGAGKKTRIVATLKELYGPGVEKIKIDARVFQTSSNRKLEFNIVASNYHLEITPSDVGQYDRVVVQDLLKEVAQTQQVDQSAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTANIIAPIRSRTLLVRVAAPTHAEICDALAQSAKRENWEVVQGLHQRIAEESGRNLRRALLMLEAVHAQNEKVTDTTPIPPADWEALIGQIAKEIYEEHTPARILQVRAKLYDLLTHCIPPTTIIKTLTFKLLNLIDDGLKAEVIKWSAFYEHRIKTGTKVIFHLEAFVAKFMRILEMYLMSMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD01</accession>
    <name>A0A2T4CD01_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1436699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD01"/>
    <dbReference type="STRING" id="983965.A0A2T4CD01"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="80"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="185"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="282" mass="30221" checksum="449090D2EA108F65" modified="2018-07-18" version="1">MSAKAPLPQNDNVAHALAGAGGGILSMVLTYPLITLSTRAQVESKKAESNLTEAIQKIIAREGFSGLYSGINSALFGISLTTVEAMIAGAIAGSATVIITNPIWVVNTRVTTRRQEPDLEAAGGDGGRRGKGPTTLGTLMSLLKKEGPRALFAGVVPALVLVINPILQYTLFEQMKNAVERKRKMTPTIAFVLGALGKLFATSVTYPYITVKSQMHVAAHNEKKEGMSQALRRVIRDEGYAGLYKGIGPKVTQSVLTAAFLFAFKDVLYEQTVRLRMARTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD67</accession>
    <name>A0A2T4CD67_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1453154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD67"/>
    <dbReference type="OrthoDB" id="10608111at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="20002" checksum="1825EA137D31B1DE" modified="2018-07-18" version="1">MSKEQKLYYYGLPLRPVTLTQEPQAFVSDPTQGIALTDLLGDDCPEEEPEHPKFVDGYPFQLPELDEDDVDLTAVDIADTWTTEQRFLYVPMKLLRGKGPAIIPSLAKSLDDACLELSRQKGESPSMTITSRPLPGIPQQQLCASRARLLGWRPIDICRCREWADELVLDEVAVRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDR8</accession>
    <name>A0A2T4CDR8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1436943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDR8"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="2">
        <location>
            <begin position="356"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="843" mass="95321" checksum="6BEBE2E3704C67D7" modified="2018-07-18" version="1">MRILSAFAARFANRQFLFAICVVAITSGKLVHIYAHITALAFRSLARWGLTFFTQDTAFLILIRLLLDTEIYPWRWLRIILTSLATLLVTIVLALAAINNAFFVVAGSEPHWRNAGLASNASSWKLAVTGLFTCLIVLAIILGISWVTQDIFYYLAGLALDILKWPFAFVYSKLPQRMRPAPANVRYAHIPQQDVEGGSELMGKEDDDMDTSGSSVVSDARRATKWTTALYVLVGFSLFLQVLLYIVRPSEGSYTYMSWTLPLLPFADFAHSSPILAALTPVYDVSIGWNWDNRTALVEPIRWEWLPKDPLPGFQDWYTAEETHYRASQDPLKISNLKNDVLPELRDKLANITIKNVVLIKLESTRKDAFPVKKDGLFYKLAAESFENGTLPETAEKKISTLTPTANLLTGDYEDGFEHKEKKRRGGLNANNCHTSASYTLKSLTGTLCGLSPLVADFNAEVSHHIYQPCLPHIFDAMNLGLGNSSKDGDKDDFTSHKWKSSFMMSVTNGFDKQDQLMVQLGFPRNNTVSKEYLKSDDAKFGKVDVEDINYYGMPEYVIEDYVRDAFKSAKENKERVFLTHLTSTTHHPFGLPEDVEHVPITSEESSKLDNVSKYLNAIGFVDRWLQKILDILDEQGVADETLVIFVGDHGLAVPENDGITPYYNTNIGNFHVPLVFSHPQLPAIDINDAVISYQILPTILDLLLETGSLSGPQTQIAKDMIDNYEGQSMLRSLINVNDKTGQPNWQFSVMNPGRATVAVRDSREPHWRLTVPIIENTEWRFTDLDTEPHEEKHLVAFDFPGFLQKIERERSVEAAHWAEQAAFVARWWVEENSMRWHYDPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDT5</accession>
    <name>A0A2T4CDT5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydroxyacylglutathione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1436934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDT5"/>
    <dbReference type="STRING" id="983965.A0A2T4CDT5"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="297"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="719" mass="79141" checksum="F7784E196B7437CF" modified="2018-07-18" version="1">MVQYVFTPWRDRQELLLVREQFYGSGALTEAASREQADGEKHKAVGRVSMWMQRGNCPHMVESTALLMAAVLSDEAAATGNAGASTYAVRAAYAAAFSRFVTGLLDGHQDKLRKQSMYSIAKNIGLPATFVELRHQATHEQLPSLAKLRSAARKALDWIWDYYWKHLGEAEKAKDPCKEMVLSYLREDDEAARQRIMGQLRQWDKGHLQTTIAELQKTLPGNQVYLKCLKLSKDMAAMAHEASGPEPEDIEMPEEQGQEQELEQDPDRSPELTTGWSRYSGVWKPKPIGIAWVGNSNNYAYLVVDDKSKDAVIIDPANPPEVAPVLKDALSSGKINLTAILSELDTDLAIIGGKDCEGVTKTPKHGETFKIGDISVTAVHTPCHTQDSICYYMEDSTGRAVFTGDTLFISGCGKFFEGNGAEMHEALNNRLAALPDDTVVYPGHEYTKSNVKFTASVSQTDPIKRLQEFADNNEVTTGKFTIGDEKDPEIQKATGKTDPVAVMSKLREMKNNFKGTEADARNTFQTQPPKRKSGGPPTAPKPRQSKLAKEHNVSAQEEAEIKEAFSLFAEPMDGEKNGVLPINDVKSALIALGIPPSSPAELQEFLSILDPESDGFATFEPFFAICALKFHARDRDGYGGRDSEAHRRELAEAFQLFTNGADGPITLAHLRRVAAVLKEDVDEELLKDMILEANGGVGVARGVGMEEFDGVMRSAGVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEJ0</accession>
    <name>A0A2T4CEJ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1107312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEJ0"/>
    <dbReference type="STRING" id="983965.A0A2T4CEJ0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="144" mass="15783" checksum="F5C86583812E71A0" modified="2018-07-18" version="1">MSPVDDCLQLDRVPLSMTTLFRVSRGIAVAAPSCRYNGRRFESVALRLYSLYGPDGLLPSPCTAFSRSAHLPRCLLFCCSMGCPQSHHIWHLVTHLLTSLFSVVIMGICGNEASPKPAKNTILYAKDLMAKTASLSWMLFGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEJ3</accession>
    <name>A0A2T4CEJ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1108047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEJ3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="13049" checksum="7246BE55156D7D9A" modified="2018-07-18" version="1">MIPGSEFWLARTTYLSELDNWFSLFFHFFVRCLGLTIGGVLRRTILVRYPATMMPRYGALAKGMLIYERQGQGPTTVRRPPRAYVLMSHYFLFLFSCACWEDGNGHGVLQTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEP5</accession>
    <name>A0A2T4CEP5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1467439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEP5"/>
    <dbReference type="STRING" id="983965.A0A2T4CEP5"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="263"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="544"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="785" mass="85070" checksum="AEF4C66BCF328544" modified="2018-07-18" version="1">MLKKSIDAKVRPLANVSLERASLLGAGRIYVNKDSLISLTGSLDSGRPCIIERLQADDASGEGSASGDAESGKRREASLWVLAEKNVSPNVVMMTRAFQEATGFKLGDVVRITLAENATVPDADEVVVQDTTGEADQQKDAAGKPRHPPSWEFSISISLDRAEQVFPGMVLEGVSINKLRRTFKVVSVNGQSNNMARFKLASSTVRILQPGDSKDAPEDAQMAAPESGPLAVTGVPGLSSQVNVINQFLRGFGRPFWIKNERESCGFVIHGGHGTGKTFILQRIAATNWGRVHWIRSTDKLSTIRETFKLAQSQQPSLLFIDGLEDILAKERSNRDSVVEALGEELDNLSAAAAAANALPQVVVMATCLDYLADVPAKLQKRSRFRENVALPIPRATERLEILRFFDPPIQAEEKEACLASLASKTHAYNGDDLANLVLNAKKILGNRLDDEAAAATAGDADTEAAGTVSSETQQPREHYLTSQDMEQALRITRPTAMHDINLKPPTIHWRDVGGQASLKKVLSRMIKNTKDTNPSSRHVLRQPPKGLLLYGPPGCSKTLSAQAMATESSFNFFAVKGAELLNMYVGESERAVRTLFERARAAAPSIIFFDEIDSIGGSRTGGNGAAAARSSGSVNMLTTLLTEMDGFESLTGVLVLAATNRPEAMDPALLRPGRFDQILYVGPPDLSAREDVFGVHLRGLALAADVDIPELARITDGYSGAEIKAICNEAGLAVLDRCDEDETGTEKMEIRMADLEAAIEKTPRNITPMMISGYEMWSRQFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CER6</accession>
    <name>A0A2T4CER6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1325622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CER6"/>
    <dbReference type="OrthoDB" id="5332316at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54766" checksum="B92F693D9864EAF4" modified="2018-07-18" version="1">MICPRWTPRATAALANLGGSSRQASCRHIRIPRKGEESGPRRWYSTTEGGNEDGISGPPSRQDSRPSDRTHRASSRSTAASIEEQTPHRLPQHQPKTAATRTANAAGPRRHWTDKKDAGGAGDAAGETTNTAYQMWPLLKRRERAGKHGDERVANAAFAIPKPIFSPRRNIQNPKGTSDSSGFMLVIDGLSPNLSATDFYRIAPNDFSNWRSAIKKVQQQRKPDTLEPLGRYWVTFSTGEAAVSYRDRLIRLHRLNGFKLRSTSGLWESSVPPSLKVSLASPPAALAAAAAAAGVVDGTSDGAQPDQPGTESVVELANSFTLAPGSQAEIPIHRQRVTVRRPWAKRLAGLVESLGFGERPPVLMVDVYPPTLTAERLHQFISRDGYNRALRWKVSVPQHLQKSYSEQGSPEMHAKGARKNGEMDEKDEVASGRQKSASLKSKDREAWETVRGRFVLACADEEEARRFQQSWNQRALTTLRPEPVRYIVRTSIIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF52</accession>
    <name>A0A2T4CF52_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1324971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF52"/>
    <dbReference type="STRING" id="983965.A0A2T4CF52"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="12677" checksum="CAF218CEE3A2EA0F" modified="2018-07-18" version="1">MSIENLKSFDPFAEADDDTGDIKKVENHIHIRIQQRNGRKSLTTVTGLPAKFDPGKILTFFRKEFACNGNKVNDEKAGEVIQLQGDQRKKVLDFLVDKKAGLGLNPDNITVHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF58</accession>
    <name>A0A2T4CF58_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1323862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF58"/>
    <dbReference type="STRING" id="983965.A0A2T4CF58"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="809"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="310"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118822" checksum="1267A1C4B9BD27AC" modified="2018-07-18" version="1">MASIRTTEHTKTDQELAVSIKKATSPEEISPKRKHVRACIVYTWDHRSSQAFWAGMKVQPILADEVQTFKALITVHKVLQEGHPSALKEAMANRGWIDSLNRGMSGEGVRGYGPLIREYVYYLLAKLSFHHQHPEFNGTFEYEEYLSLKAINDPNEGYETISDLMVLQDKIEQFQKLIFSHFRNVGNNECRIAALVPLVQESYGIYKFITSMLRAMHSITGDDDALQPLRQRYDAQHYRLVKFYYECSNLRYLTSLITIPKLPQDPPNLLATDDDAPALPARPKQEIERQPSPAPAPKSDEPDEISEFWKGELDRQNREYEEQQRVLEERQRAAILAQQQAQQQAQREFEDQQRRLMEQQQREQEALIAQQAQWQTQGRLAELERENLNARAQYERDQLMLQQYDQRVKALEGELMQIQNSYGHQMSSKDDQIKALQEQVNTWRSKYESLAKLYSQLRHEHLDLLQKFKAVQLKAASAQEAIEKREKLEREIKTKNLELADMIRERDRALHDKDRATGSSKDEVEKLKRELRLAQERADNLERSKGNELSTMLSKYNREMSDLEEALRIKSRALEEAQSKIRNGDSDLEQLLREKEEELEVYKAGMDQTLIELNELKQNQGETDHALDGQIDALILSNLDKINDMIDSVLQAGVSRVDDALYELDSSMQAGNQNASPSYVLSQIEKASGSAMEFATAFNNFIADGPNSTHSELIKAINVFAGAIADVCSNTKGVVRLATDDKKADALMQGARQSAQSTVQFFRGLQSFRLEGLEPLQKTDVVINSNNDVQMKLQKLNKLVEGLAPGYGKLMNNKGDLGDLVDSELSKAADAIAAAAARLAKLKNKPRDGYTTYEVRVHDSILDAATAITTAIAELIRAATATQQEIVQAGRGSSSRTAFYKKNNRWTEGLISAAKAVASSTNTLIETADGVLSNRNSPEQLIVASNDVAASTAQLVAASRVKAGFMSKSQDHLEQASKAVGAACRSLVRQVQNMIRERGQEEDQVDYSKLGAHEFKVREMEQQVEILQLENALTAARHRLGEMRKISYQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFE6</accession>
    <name>A0A2T4CFE6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1435921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFE6"/>
    <dbReference type="OrthoDB" id="5124663at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="172" mass="19182" checksum="DDBC4F4E984BC997" modified="2018-07-18" version="1">MTPDGKLLTNHQNRDFLTKYNLEPDNGAARRLTTGPAIQNASKAYNATIAFSPRHIIHPHDLRFFDPRGHPLAAARRAKYLRKTLEEPLWIMLTGAGASSVVRTLTQRRLKCAIYRSLEDLGFPNGVGDGKEIRGTLWITIHDSVKASKLSPWPFGEAVARALTSRCAQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFG9</accession>
    <name>A0A2T4CFG9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_189540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFG9"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="186" mass="20564" checksum="9F61035DC33559D4" modified="2018-07-18" version="1">MPAPGIVIPFDISLHSHLTPYLAAIHASCITHDHTIATFLLPLSHEKLLSWWKERIAETNDGRRLMLLLVSEMDPGGRIKGPELIGVVMLWMPYSETGSFRGYVEKLLIHKHHRGKGGARALMSALETEALNRGRTLLLLDTESGNQAEAVFNRLGYTELGKVPGYGMSPAGGLKDGTFFYKTLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFJ4</accession>
    <name>A0A2T4CFJ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_191297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFJ4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="18145" checksum="504B7C42EABC85BB" modified="2018-07-18" version="1">MPHPALARASNTNANRLHVTGHPTTCTLSPSTSLLVPLRQMASPTCCLWLAHIPIGHGKSFQPAFSHQCAVSLLLPSPCWKRHLASPLLVRHRDSGFFLLIQTTAQPMKLPMSPRLASFASLSSPASSFPHFYLHAPEAWHDPRRPAYQTPKSSPSPQRAQHKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFU1</accession>
    <name>A0A2T4CFU1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1348371</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFU1"/>
    <dbReference type="STRING" id="983965.A0A2T4CFU1"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="77"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB80413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="257" mass="29310" checksum="07EDDAD09EA65B60" modified="2018-07-18" version="1">MSTTTTTTTTQAQPITAETILRLFPDIDTTSEALSGHDEEQIRLMDEVCIVTDENDAPIGTASKKICHLMTNIDKGLLHRAFSVFLFNDKNELLLQQRASEKITFPDMWTNTCCSHPLSIPTETGANLVDSIAGAKRAAQRKLEHELGIKKEQVPFEDFHFLTRIHYKAPSDGKWGEHEIDYILFIKANVDVDPNPNEVQATQYVSADGLKKLFEDPNLKFTPWFKLICNSMLFEWWSNLDSGLDKYTNEQEIRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGG0</accession>
    <name>A0A2T4CGG0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1370018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGG0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGG0"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="237" mass="27297" checksum="134B0DC9F39FAAC8" modified="2018-07-18" version="1">MSDSKSKSAYGQAASDTDFRKNWDLDEYAAKAKEREQKEREEGKARYEAKLAGKKYHKPMTGNETYTSARRNIIDVSAQVGKTQLVPAGAGVGKRGRGAGFYCEACDLTFKDNLQWVEHLNTTQHLLNTGQTTEVKRATVEEVHARIEYYIRRKEELEKEKATSLQDRLKLREEEMEKEAEEKRKKRREEAEKKRQEKEQAAKVKTEYGEDVRVEGEHDEDDMMAQMGFTGFGTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGH5</accession>
    <name>A0A2T4CGH5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1348845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGH5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGH5"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="409" mass="44709" checksum="E0FF74E1F1DA8D69" modified="2018-07-18" version="1">MSDLDKAIAQLRSCRPIPEDQVRELCHRARELLIEEGNVVTVTAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRMTLIRGNHESRQITTVYGFYDECLRKYGSANVWRYCCDVFDYLALGAIVLGASSTLSPGSPDDDDTEIEVCDQAGSIISRFPRQPRPSSPQDKLDAPSKGTPDKTGPPGSGASGSSSGSVGNPTGAILCVHGGLSPLVDTVDKIRLIDRKQEVPHEGAMCDLLWSDPDEIDGWGLSPRGAGFLFGADIVKVFNHRNDLSLIARAHQLVMEGFKEMFDASIVTVWSAPNYCYRCGNVAAVLELTEDDSGTGIFQRTNGDVGRSSGGVVEPRGGPKYGPARRYRVFQAAPQDSRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGI4</accession>
    <name>A0A2T4CGI4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1436195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGI4"/>
    <dbReference type="STRING" id="983965.A0A2T4CGI4"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000060">
        <property type="entry name" value="Mitochondrial carnitine carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="141"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="340" mass="34983" checksum="B5FAE4A39BBD999A" modified="2018-07-18" version="1">MSSSPSSSPSDAVSKLADKIPSSAHEAKETAQAAAPAAQSALLSQLRALAAGGFGGVCAVVVGHPFDLVKVRLQTAERGVYSSAIDVVRKSVARDGLRRGLYAGVSAPLVGVTPMFAVSFWGYDLGKQIVGAVSPVSPEGLSTGQLAAAGFLSAIPMTAITAPFERVKVILQVQGQKQLAPGEKPKYSGGLDVVRQLYREGGLRSVFRGSVATLARDGPGSAAYFAAYEVIKKALSPKDPVTGKPTGQLSLTAVTCAGAGAGVAMWIPVFPVDTVKSRLQTAEGHVTIGGVIRELYGKGGYKAFFPGFGPALTRAVPANAATFLGVELAHQAMNKMFGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGW2</accession>
    <name>A0A2T4CGW2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1135782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGW2"/>
    <dbReference type="STRING" id="983965.A0A2T4CGW2"/>
    <dbReference type="OrthoDB" id="5416983at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1221" mass="129303" checksum="6353F9BA109201A4" modified="2018-07-18" version="1">MMATEPSTDNSADVFASTEPQPASDSRHGDLEAPAVNGGSPLPEDIANKRITNVEDQINSADVSVSGGSDTEASRAKDGEKGISRTGSAAKKPTTFKAVSVNKTFLASKANPSVSSKTSDKPAAGSSTPPTGSATLSISRPRLVAKSGSGTGTSSPRFSSLANGGKPAAAPDPNAVWNKNRPPEPKKFTDEELKKYGIHMASRLNEEDTQGQNKWADIDDDDDDWAPEVITWGDGTKTTLPHPDETAKAAERAPESTKDTASPDKPSSPVPSAAATSTPVPKSGGLPSGKGLVLKSAAQEKPVLVAKPPAPPAPAKSPWATLPPVKKASPGTMEPGYPPRGSLRESSFSSNMAPLPHREMGADDYSRSTWRDRSSYGNKELFNSRSGRYEPVPDRRPSMRSDSQTRYPALLQRGPPPDHPAEPSAAFQTSRTAPDAPFGRRRGSSNVSGGSGTYLQRLSKGHDGSVPPGPEFLNVRRGSMAGSVLESPVSPVAVSVMSQGQSRHQPLHDPASRPSPATSYATPHQGTSHPEHHAPPPPSHKLEDDLEFQKKLMREGIEQARKRRQEEEAREEAARRERIQKKLEAMGPPPEKKSEAKEAPKEQGAARPTSSQQPAPSDQASAPPTAKAHHPHQTDSGRNEATNVTRIEKPGFSHKDASATNIVPPAGPAARRPSHSQDAEPSSVWGSRPERFSSWVAGTPRNVWSSPDNDNGLGNGTFNPQLSRVSGASAQPASAGNAPAPIAPPTTIQSSHNRNQVPAPIGSRASRYGNMGAELANKWVTAVAENDKRMNAEKLAERTGRERQLAERGISVEDAQPTIKDTWRPVHIPGDGTRRTVSSSEGQLKSAEDALMGGQSGVLGNGAGSSVLPPNGPTTTPQSRPSRFFPTRDVRAEVGVIEPLRPSTPSPPPPTMEGHPVYEGDHTRPHVSLPKPQPVVKLPPAMVAAQALQAKASNPWTNRAPSREISRAPIPHGYPARRVSETSQGNWQDKINNLLNGGKASPPKHMGIDPASRHALDHSSNQQPTTVSLPAATVQHTTEPPQTLTSKPMAEDCFEEQEMGSLPRIRLPHNAPEAAWQPAASIKPMPKRFFVQPSVAEPYYFPAEVAGGGNVVRVYFPGMSEPRTATIPFSAARGGRGSHRPSSRHRGGGGHGSRSGGGGGGNGNGSGNGNGGNGKREFSNSYGDAANPNSGSRGSRGGYRSRGSDNWNRFSQPREQGSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH40</accession>
    <name>A0A2T4CH40_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1000767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH40"/>
    <dbReference type="STRING" id="983965.A0A2T4CH40"/>
    <dbReference type="OrthoDB" id="5243398at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="896" mass="94248" checksum="FFD55DB71536D8A4" modified="2018-07-18" version="1">MAAASASATLAVSDSPTLGDSLAKADAATESSATPGAQSETPIRTSNHDVTEVPDGASIHTTDGRVKNPVPSKLKGKADNKNGNFGVMHIDINSSQAALRNAAAKRTSEETEAAARLANMRGYQSIKRSKLAWIPPSESDPRSSAPAYRASQNGYLNAAYPPLARPLGPLPHEAKAEQARLLTLLRSLNPLVVVDQLCKALAYFGGIPGAPSSHDFVFPESQRNNGQGSIFVGWVAEIFPPVEGNPTAIAPHPSLQTAEIASAAAAAVAVASSDMPASSQPTNLSQPAAAPPAAPTSTDAAAQASQPAETQNAPAATPVKRPRGRPKGSKSSKPRIDKGIKKSDLAHHHHASSQADAHSSHNALNLSQNDQASTEQRNGLHNPAFPGDIQANLDPDSSIMSTPGTGKKRGRPKGSKNRPKNTPSRAPPAATSAPQTLLPAPNSSNPMAPSPLSHKSTGSLNNIASYPNSMPSGTDHQQQQPQQQQQQQQNPSPTMQEGAVGQHNGHMAVRNHQTSQTASIPAASSWAGSGMQSLDPYRSANNHSHGKKRKVGDPAQLARDSLSALAAPDASSQMRQSDDNPLQMAPPDSATMKRRRVSRETMQNPMYSNIDTQSGRVGMNTSPILNNNFNSISQAMAANNFDSQLASAAVRKASTQQHLQQQQQQPPQRSPTQAQGQNVSQSLQNQQQPQHFTSQRPQQQNPGVRPPQLQQGGHMAPGASRPRPGQMYGNSPTGMNAQGFYAQARQLPGQLGHVTGGGGGGSFARSTGSGQASQFGSSNMARQSSDDRAVSLSQQASLAISRSQAGQQQTPTARHSSSGFPNGQQVPATSASVPTTSSLSQFQNFAEHSYLDMDYGLNERDVQDAAAAFGDSTQLEAALAEGNIRERLYQAMTNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHE8</accession>
    <name>A0A2T4CHE8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1443149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHE8"/>
    <dbReference type="STRING" id="983965.A0A2T4CHE8"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="418"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="470" mass="51930" checksum="7919CBDF838FD7C7" modified="2018-07-18" version="1">MEPGDVGTRQSSLPSTPTRPEHQPLQPPHPQQQHREAVDRRYLDQPVMAAASVLAPNAHYPPQPYPTSYSHPPSSGPTVANMISSEPRRPSPDNESSTRQSLPSISEVISGARPGQYPPPAHPPLQPGASLPSPFAPSARQYPEADKHSSQPLHPAAFPPRQESHAAYSDSPRAPFSNGRPGLPPPVSERRSTPPTKHDAHPLPHHMAEPPKPSDHRSLNGVYSQPPPPPTSVPYQPAQLPPGQQPLPPYQVSPRGHPASHLPGQYDARPAPTHVEEAEYAARARYDNGTSRSFESWSYQEALSRIGTCSRTIFNFAEAYGRIAQEQHGSQPIPERLPTEREVSDMLSNVEYLKRSLEQCREVIVASLQSERAREGAKPPKGPYEEDQDVPMYGDSSKPPYGMTEVKKRRGRAAPPGRCHSCNRIDTPEWRRGPDGARTLCNACGLHYAKLERKRQLEARSLRPKPEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHZ6</accession>
    <name>A0A2T4CHZ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1322612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHZ6"/>
    <dbReference type="STRING" id="983965.A0A2T4CHZ6"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:polyprenal reductase activity"/>
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        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
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        <property type="term" value="P:polyprenol catabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
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        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="201"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="320" mass="35713" checksum="451769D58C7A9C0D" modified="2018-07-18" version="1">MESISNLLATLGVSDLTPAQWCQIFFVANAGFILMLQALPDDMRRALMDYGARRATSRRASTKKGEAGATKEGFFDVLTSYGQVPHSWFIHFYITSVSWSIFWGWQFVSKGSVMRALAERQHNAAGEDASSEVELTATLVAWLLMSSQGLRRLFECLFVTKPGSSGMWFVHWILGLAYYTTLGISVWIQGSGAILRSWESPQPIHFTPQIIIGAAVFGFAGAQQSECHRYLAGLKKYTLPSEGWFKYFVCPHYTFECLLYLSLAVVAAPTGSWMNRSILCSLTFVLANVGSTAYGTKIWYAEKFGADKVEGKWIMVPFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI04</accession>
    <name>A0A2T4CI04_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1466780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CI04"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="193"/>
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        </location>
    </feature>
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        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="514" mass="56367" checksum="69F2085234A61D6E" modified="2018-07-18" version="1">MSAAAMLPDDGRQASTASSSSARPGHAAPSGISFGHHSTSATTTTSSSSPSAAGNAPPGHFLRRARTVDEPSMRSASMSRHMSSDSSSEAPPRRSSNFSEYSLSEARDILNPRPYPQGEQVSNYEASPLASLSLAFALLPAIAGVLFQNGTSVATDIMLLGLAAIFLHWSVTQPWQWYHAAQEVRIVEERSMSMSSLEPDSGLDSQTKSPTSNGPLDDVPEEQEASEEDGSSSEKRETRIEQMTAQQQAALRELYRHESLALASCFLMPMLSAYLLHYIRGQLTRPSEGLVSNFNLTIFIMVAELRVLSHIITLVQSRTLHLQKIVQDSPLGRQQAGTETLLQEMLKRLERLESLSTSQSNTLAGHGESLSSTTATVSREVRNTIQPELDALNRAVRRYEKKATLLQLQTESRFTQMHARLDDAISLAAAAAKTSNQRQHWLPWIWNMIVAAVTFPFRAILEILALPLKPIVAFANRNKQASSTTLRPPRSRPGKLPASVKYSGDRVPTRLVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI30</accession>
    <name>A0A2T4CI30_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1010206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI30"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="12879" checksum="86E55B2D3752555E" modified="2018-07-18" version="1">MVQTASSSSWCVVSKPTRGPGWWFWRCHSASVSSFRRRPRSALPRRMPSDRRRDSKKHRIQATRGNPPRLELVLGELDHITAQNMQLCSLFSALQVKDSDVVWPGSAFENMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI56</accession>
    <name>A0A2T4CI56_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1321541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI56"/>
    <dbReference type="STRING" id="983965.A0A2T4CI56"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="661" mass="76048" checksum="3FD62BAD31807F88" modified="2018-07-18" version="1">MTLSEQQRWITVQEKTFTKWLNTKIGVRNLEVKDLVPDLSDGVMLIHLLECLSHESLGRYASRPKLRVQKFENANLSLDYIRSRGIQMTNIGAEDVVDGNRKIVLGLIWTLILRFTISDINEEGMSAKEGLLLWCQRKTACYNEVQVRDFSSSWNDGLAFCALLDIHRPDLIDFDTLDKSDHRGNMQLAFDIAHEEIGIPKLLDVEDVCDVAKPDERSLMTYIAYWFHAFSQMEKVENAGRRVEKFFNNMQGAWEMQNAYERRMRELLKNIRGQIEQWHTAKFEGTYADAKAQAAEFSEYKRGKKREWVAEKSELATLLGNIKTKLSTYRLRPYEPPAEVSQEVIERDWSGLTKSEMARAQLINETIRDIKNALRKSFADKANDFAMALNTMQLAISGLDGDIEDQLHHVKKLSDNLQPLDRYLSTIAEVDAMCEEANIEENDFTTYTYDELAYELTLVRSSVQKKLSFLENQMVARNMTNLTPIQLEEFESVFRHFDRDASNSLQELEFSAALASLGLVFSEEEMHDYFVETSGGNQYVTFEQFIRFMVDVTEDQNTAEQVFQSFREVADGKPYVTEMDLRHSLVPEEVIDTLLNMMPPHNGPDMSRDRGKAQYDYISFMEKMMGGDDADDDIPAGVLQDRTNIGDNRPRRDSKVNGVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIA9</accession>
    <name>A0A2T4CIA9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1387738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIA9"/>
    <dbReference type="STRING" id="983965.A0A2T4CIA9"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="187"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="669"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127271" checksum="EC8898FE5DF84CC5" modified="2018-07-18" version="1">MDVEGQPPTQPTQATQTVLDPRRIGKQNSGFSDDDVSDIICVLYPHSQAARLEVQQLAASGSPYIIGKDEADGVEVDYDAEDDASHFDEMPPDLGSHALILRLSSQVKNPAAGFQFGRNSARCDVVFVNDPLRRVSNIHFRIYINEYGTVMIEDHSTNGTTPSEQRSPTKRKEARVPQRQWTGSGKYNKIGMIGKGAFAVVYKVTSKYNGVPYAAKELEKRRFIKNGVLDQKVENEMRIMQKVDHPNIVRYIENFDWDDRLLIIIMEYVPGGDLGKHIADDMPFSESDSREMAKQLLSALSYLHANNITHRDVKPDNILINSLQPLDVKLTDFGLSKMVDTEQTFLRTFCGTLLYCAPEVYTEYAEYDENGVRSRGKKARRVPGQRYNHAVDIWSLGGVLFYSMTGQPPYPVKSGISYSELLHKIMTTLLDIRPLERCAISDDGIDFICSMLQRKPENRGTIDELFRHSWLSPLYIQASPQSFDVVSDDEGVLSDPPPEYREHEYEEEQFEFDRVSDSNGEEEEEEEEERRREAGEGRNKGKEPEDSDTENDVPVTTRLEYPIEEAMHIGTQRPPRLFGEIGASAFGNSGAVPEDHLNLPVTNGIGSGSGGAEGDVDEAYDSGDSGATLVKRNNRRFLRRGTSMSIGRHQSADQLQSLVEEVASQKLDGNESAVKLSDPATPTTPSMDFNTSKRKTSSSLEASDELDLESTPTGKPVIKRLKSESFSGDVSAELLEEYRLLATMPPIKKSNSGRQIDRQVTKSLFWQQDRSTWHLNYPEMTQLQYDAFVQAARNRKEEFGPNNKPLWDLAMRYFPPTLPAADSSQASLRPQDEDVLMDIPSTGDQAGYEDPDAGRPDIQRIVPVQTDSGNQVRGMITSHERSCIQKIEIRITDSLISFGRGMGNTVVFEPKTNTKVPKHAFKILLWKDGYDPAKDPLPWKDDAADEDSYFFWISSKATIGISINGQRIPSSNPSKPSSPSVHWAKIYTDDVLDLWNSEDGREQTKVVFQCFWGGSRRSRADSSRGPRLEMASVAVAKVLDVACQRTERRIREAALKQGEERSRDSADRQAARRRIMSALEAENRERLLRIDAERNRSHVFEQSRLAAIQFLASRQGSLSSRRESSYAGYSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ06</accession>
    <name>A0A2T4CJ06_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit gamma, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1396717</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ06"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ06"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="256" mass="27912" checksum="2795AA4CAD83CD14" modified="2018-07-18" version="1">MLSRAARPALRAAAAAPSRAAAAGPSTAATYATLREIETRLKSIRNIEKITNTMKVVASTKLTRATRSMNDSRKYGEASNEPSAFDLVIIGEKCKAQLQRTNGKDIQLTFAGVGKDIPTFADAQAIADQIVLLPNEYTDVKILYNKFINATSYEPSFIEAFSEESIAQSPNLSAFEVEDESLGNLREYSLANSLYWALAEGHACEQSARRNAMENASKNAGEMIGKYQILYNRTRQAVITGELVEIITGAIASEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJK0</accession>
    <name>A0A2T4CJK0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJK0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="51" mass="5493" checksum="1C6D390CE34E8831" modified="2018-07-18" version="1">MRRVGRPTPLDTVWRSPLLLIQLSSMQAYTLGPAASAKGSREGSAHRFAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP98</accession>
    <name>A0A2T4BP98_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1345063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679155">
        <property type="protein sequence ID" value="PTB71069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP98"/>
    <dbReference type="OrthoDB" id="3799035at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="59" mass="6982" checksum="F24691ECF07F9AFB" modified="2018-07-18" version="1" fragment="single">YYFIYKKVKRGEVKLKYIPINKIVANRLTKLLGKDCFIKFYKALGLRKLTNIEIASKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPH9</accession>
    <name>A0A2T4BPH9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1387093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPH9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPH9"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="10">
        <location>
            <begin position="76"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="298"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="496" mass="53346" checksum="E20F2F19B7D9AFD6" modified="2018-07-18" version="1">MAASVRVIPNAAKRASSLLRTIQYTHPPSCPCHSNPGYHHRRAPTPLSNTQNRGGRRYATPSNADLKEYAFEMAASSIRFGAGATQEVGMDLQNLGSKRVCVVTDQTVNQLDAMRQVRESLDREGINYKVYSDVRIEPKDSSIKDAIAWARPYEPDAFLAVGGGSVMDTAKLMNLYSAYPDADFLDFVNAPLGKGLPIDKPLRPLIAVPTTAGTGSETTGTAIFDLVSKRAKTGVAHRNLKPTLGICDPLNTRTMPAAVKASSGLDVLCHSLESWTAIPYTERTPRPSNPILRPAYQGANPISDIFSLNALKSTIKYLPRAVKDPEDFEAQSEMLLAATLAGVGFGNAGVHLCHGMSYPISGQNPGYKHAGYDIPNPLIPHGVSVAVSAPAVFRFTAPSNPERHLIAAEAFGVDISNVKAESAGEVLAEALIKFLQDLGDQPNGLKDLGFGSEHIDALVEGTIPQARVLKLAPSLSTELQTEKEQLRALFEDAMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPR7</accession>
    <name>A0A2T4BPR7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPR7"/>
    <dbReference type="STRING" id="983965.A0A2T4BPR7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="60" mass="6577" checksum="040F7DC04C10401B" modified="2018-07-18" version="1" fragment="single">MSGDSAPPPIDSLSIEHQQAKTERVSGRSNSFSQQSRASDDSQTAAEYVAIRVYEAHRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ71</accession>
    <name>A0A2T4BQ71_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-mannosidase B</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_23183</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ71"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ71"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="18">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="15">
        <location>
            <begin position="197"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="17">
        <location>
            <begin position="684"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="16">
        <location>
            <begin position="782"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB71458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="854" mass="97012" checksum="C8B058D041CC68DB" modified="2018-07-18" version="1">MAPRKVIPVDANWQFGRTDVEKPEFRPVSQFPTNVHLDLLHHKLIPDPFIGKNELDVQWVGEVRAWQYRTSIKTPKIGTQEKAILAFDGLDTFAEVLLNEKKILETDNMFIPERVDVTALLNDTDKDNQLVITFDSAYLRGWERVEQIPEHRWGNWNGDYSRLAVRKAQYHWGWDWGPTLLTCGPWKPINLEVYESRFADLYANVTLDGALTSAKVELHAETEGKASKVRFELSLGETVLSDTVDVSKGGAVAALTISNPELWYPARYGKQPLYTVKATLLDGSDEVDTLSKKIGIRKVELVQKPLEDQPGTSFFFRVNNIPIFCGGSCWIPADSFTPRITKERYQNWIRLMVEGNQSMIRIWGGGVYEDEKLLDACDEQGILVWVDFLFACGNYPCNPEMLQSVDKEARANVKIMRHHPSIVVYAGNNEDYQFQESEGLTYDVQDKDPLSWLKSDFPARYIYEHLLVQVCQELVPETFYHYGSPWGGKTSSDPTVGDIHQWNVWHGSQARYQDFDKLIGRFVSEFGLEAFPSARTIDAALPKGKDDPDRHAQSDIVDFHNKADGHERRIALYLAENIPYVTSPLEQYIYSTQLVQAECLSSAFRLWRRQWKGPGREYCSGALLWQLNDCWPVTSWAICDYYLRPKLAYYTVKRELLPITVGIKRTEHRHPKSKYTRVDIDVSTKLEIWASNFTLDEVKIDCVVKAWDVETAEEVYSEAIASSQPLPGNRTTELKTMEVPVKASNAGLEGRTVVAAYLYQDGKLLARYVDWPQPLKHVHLQQPRSLKVKLSEDGSAVTLSSDVPVKGVALEVDDEGVKFDDNLVDLVPGEEVVIGVTGASKSTVFTTRYLGMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQK7</accession>
    <name>A0A2T4BQK7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1386232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQK7"/>
    <dbReference type="STRING" id="983965.A0A2T4BQK7"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="358" mass="39194" checksum="188A9709CDA87646" modified="2018-07-18" version="1">MFPPVEQKILQSNPDFAKLYRVITTAILNPDGSTKDDAEAKDRAAVQKGLDKHRHKATRHYLVERAIATATPPEPRPSPSSSSTTSTRLSRASERLQQRQAQSSAEATPEALLELLLILPSFLDAVDTLPRDSLTLLLSSPPLSSFEALLPDLADLVACNLHASALGLARIAHPAVNPSYLHRHVASLPKDFAALGANLATAEEILNAARVRAVASLTKLLGILSECLTCLVRTLEAKHGVIARSLELRASDVSLEAQRAEKLAEQALWRLRREVYTPESAVALQRYGAHLKDANERIAERARRLQDELDANDGRSSRGDLQHDDEHDVDVEGRGPVAYADGGKRVDDAQRDINRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQS2</accession>
    <name>A0A2T4BQS2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1426425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQS2"/>
    <dbReference type="STRING" id="983965.A0A2T4BQS2"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18074" checksum="84693C6014D3F450" modified="2018-07-18" version="1" fragment="single">MSDQGTYNNWTKAGLIQRVKELEKQLKASSSSHEAISTTASDQQQPAKSEHEHEQQQKQDDQSETAQQPAKKPKSKTKKKMDPSKYATRYIALKLAYLGKNFGGFEFQAMGNQPSIEEELWNALTKACLIFPEDERVVDFECCEYSKCGRTDRGVSAFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR68</accession>
    <name>A0A2T4BR68_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1426146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR68"/>
    <dbReference type="OrthoDB" id="4900297at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="6">
        <location>
            <begin position="160"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="369" mass="40537" checksum="0A3AA7F20E5CA0B8" modified="2018-07-18" version="1">MSQPKAPGAKAPPHAHYWKPCALEMRGWFFGGRGLGIQTAIQTVLYVHRESEATSWEGFTIEMPLGKNNEDDGFGVTQRYRSRPSPPIITKFEVRFPIGSRFIVQEISEGTLAKLPKTDKKMSLLEVHSEERPTVRGFGMPFANPGHPNELQLGCRRPLRSPRTHSKRNPDQVANALDFLADMVKTGRFKPADFAIITPYAANVGLTERLRERAEYAILLGMPPTATVDSFQGREAGIMVVIMGTTEEVGPGFTTDAHRLKVMLSRQRSGLLVFGDINVVETPEPAPGPASGRGGRGGRGGNYVVEHNGVRKLVRDGMLQQVLKGWKTAGRVIMLPPRPKAKSKATAVPSQQTRVQAGPSSLKWSAPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR69</accession>
    <name>A0A2T4BR69_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1473218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR69"/>
    <dbReference type="STRING" id="983965.A0A2T4BR69"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="513" mass="56609" checksum="8484F0BD6A970366" modified="2018-07-18" version="1">MSETNSKVEVADVELVIGGPTGLLTGLLLHRLGVCVSILDAKSQSLDLGRADALNARTQQYLTVVGILDELLPLGLKCNTSSTFGEGEFISRQNKWWVGLEHTLHKNFLMIGQPVIEKILSNRLDGRVHYGEQVETLLETDDFVQVVAKSGHTVHAKYALGADGARSTVRAAMGATFTGTKPEMLWAVLDTFINTDFPRCPEIITFQLNGQSRVSWIPRERGLCRFYVLLEGEVTQERAEESIKKHLAPYRTEFVKTEWYSTFDVKERIASTFISRDGAGRVFLAGDAAHVHSVNGGQGLNTGIADAFSLAWRLALVINQASRLKEGAARTLLQSYDIERRQTAQGVIDVAAALVRDTVHTARQYVGTIEKNAGYITGMGVAYDGMESPAVQESGHGFWRAGKRCPDAVLSQPDVDGDIWLYSQVTYGEFLILAIGNHPKQVPTHEDTAVLFNILPSSANVEGMATSRTRTYIADWAKPNEAFAVLVRPDMYIGYVGADIESCHRYLDRLFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRA2</accession>
    <name>A0A2T4BRA2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1137164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRA2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015748446" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8456" checksum="557BCFB722BDB4DC" modified="2018-07-18" version="1">MRQIMLLITLETCLFSKCWLKATPGSCRAGSSLSIKAFVHPHNATASRFPDKETFPSWPQQTVNPTKQISFESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRS5</accession>
    <name>A0A2T4BRS5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1103787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRS5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="12475" checksum="3F6D03802D98486A" modified="2018-07-18" version="1">MFDLSSPRPSPPLLSMWCRAATLLFLLGLLALFPVCYLFRSVHPGADPKRLAHSHNTIHTRTHQTSCACHGLPARHLDPTSTYMVQIDRLDCWLDSLHTSTTKLCAGYDGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRX9</accession>
    <name>A0A2T4BRX9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1098310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRX9"/>
    <dbReference type="STRING" id="983965.A0A2T4BRX9"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000046">
        <property type="entry name" value="TBC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="290" mass="32017" checksum="E5A7F052A6920B8B" modified="2018-07-18" version="1" fragment="single">AYRAKIWAECSGAAALRIPGYYDSLVSQSGEGDDAAVVSQIKMDINRTLTDNIFFRKGPGVQKLNEVLLAYSRRNKDVGYCQGMNLIAANILLITPSAEDAFWILASFIENILPQGYYDHSLISSRADQQVLRQYVRTVLPKLSAHLDALSVELEALTFQWFLSVFTDCLCAEALFRVWDVVLCTNDGSTFLFQVALALLKLNESNLLQCDTPAAVYTYINHHMTEHAISIDGLIQASEGLRKVVRREDVEARRAKAIQAEREGLGLSKRDGGVLSVEAGGDAHGEDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSC9</accession>
    <name>A0A2T4BSC9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1342542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSC9"/>
    <dbReference type="STRING" id="983965.A0A2T4BSC9"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="133"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="361" mass="37829" checksum="1D4EE7BC87D36EED" modified="2018-07-18" version="1">MKAAAPINSIAHKLGSQSFLPETLDKECDKAATILKAFCKKGVYADPAATSVPTSTDPNAVESTDRVIDPTKEKPKNRVIVTIPPKVISKAVGLAIFTTLRAGFQVSGATGSGILIARLPDGSWSPPSGIQLHSVGGGFQIGLDIYDCVCVINSKEALAAFTNTRVSLGSDLAVVAGPYGAGAAVEFGAALEPKGKHGHQEGPEAQQQQPPQNLQPEDNSKKSHRRSLSASATKPVFSYVKSRGFYAGIRIDGTVVAERKEANAAFYGQTVTVDQILKGQVPPQGPPGMWPTGAQTLYTVLKGAEAGALQAFSGDSSPRLHQQQAAQGYDYPHPGPGQQQTSPPSYADSGPRPIDGDIKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSE1</accession>
    <name>A0A2T4BSE1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_366438</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSE1"/>
    <dbReference type="STRING" id="983965.A0A2T4BSE1"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="100"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB72218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="23320" checksum="6467BFFD3CD9E57D" modified="2018-07-18" version="1">MSIGTFSLPALPYAYDALEPSISAQIMELHHSKHHQTYVTNLNNALKTYSTALSANDVPAQIALQAAIKFNGGGHINHSLFWENLSPASSPDADPASAPELTAEIAKTWGSLDKFKEAMGKALLGIQGSGWGWLVKEGSSGLRIVTTKDQDPVVGGEVPVFGIDMWEHAYYLQYLNGKAAYVDNIWKVINWKTAEQRFKGDREDAFKILKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSF5</accession>
    <name>A0A2T4BSF5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Elongator complex protein 3</fullName>
            <ecNumber evidence="16">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1342124</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="16 17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSF5"/>
    <dbReference type="STRING" id="983965.A0A2T4BSF5"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="94"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="408"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB72225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="567" mass="64317" checksum="0668D9E767D0C1C5" modified="2018-07-18" version="1">MTAVATSQKKTVELAPESERFLRCCADLANALIEDHEATKNGRPGRDINLNSLRAKLAKKHKLANIPPLTAIIAAIPEHYKKYILPRLIAKPIRTSSGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFEQARGRVDQLKSLGHSVDKVEYIIMGGTFMSLPASYREDFIAQLHNALSGYQTSKVDEAVEAGEMSNIKCVGITIETRPDYCLQPHLTDMLRYGCTRLEIGVQSLYEDVARDTNRGHTVAAVAETFCLAKDAGYKVVSHMMPDLPNVGMERDIDQFREYFENPAFRTDGLKIYPTLVIRGTGLYELWRTGRYQNYTPNQLIDLVARILALIPPWTRIYRVQRDIPMPLVTSGVENGNLRELALARMKDFGTTCRDVRTREVGVNEVKHKIRPNQIELVRRDYTANGGWETFLAYEDPKQDILVALLRLRKCTEKYTYREELIGQPTSIIRELHVYGTAVPIHARDPRKFQHQGFGTLLMEEAERIAREEHGSDKISVISGVGVRSYYKKLGYWLDGPYMSKWLDGRDQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSV8</accession>
    <name>A0A2T4BSV8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1385068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSV8"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="351" mass="39327" checksum="6FDA4AFC35ACE06D" modified="2018-07-18" version="1">MYMYSKFWPKGGSSGILHHYTETLVTFEYTSSSARQPHSILFVGGLGDGLATTSYTSDLVRALQPTEWSFFTLNLTSSYQAWGLGHLDRDTDEIAQCIRYIKSYKNSKYGYSKLILMGHSTGSQCVLHYLSRPNPHVFVPPFDPELEHVERLALDGAIMQAPVSDREAIQWVLHHGFGGKSGAELKSVYETLQTMAKDAALKNPSSDSMLPMWMTSQIGYPSNTPLSCRRFLSLTSPESPASPSDDDVFSSDLTDEQLKKTFGMVKQRGLLKHKLMVLISGADQSVPDWVDKEKLLSRWKNATNQGQLVGQWDEEHSGLIPDASHALSNDDQAEPRKFLVERVLGYLKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSY8</accession>
    <name>A0A2T4BSY8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1341913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSY8"/>
    <dbReference type="OrthoDB" id="4888347at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="95" mass="10083" checksum="B04A169B957FE807" modified="2018-07-18" version="1">MTTREVAALISQSHPVPSCPGPVTSTTEEPPQSLLAKQRNLAPTTSADPTNEQDAAPLEDADKEVLVERVHNTGAQTPASLAAQIEHEEQQKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT46</accession>
    <name>A0A2T4BT46_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1090087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT46"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="156" mass="15813" checksum="B66ED99E79DACE0A" modified="2018-07-18" version="1">MGGEVGSDGVFGVDADKTDGQTLDGHALATGAGGDSVRFIQWRWFGCIEHCAVGCLLRGGLAVAGAHPHGRDAVAALFETVLAATRPAAAQGCAPPEGAVLPVHWNLAVAQAKAEGKTEAIGDDDADADDGCLRGVRASKGAERGNCVFNEDSEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTF7</accession>
    <name>A0A2T4BTF7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1441871</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTF7"/>
    <dbReference type="STRING" id="983965.A0A2T4BTF7"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="280"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="488"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB72536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="549" mass="60195" checksum="F5D414F61E1CF75A" modified="2018-07-18" version="1">MADSSWGEHAYATLLLNDAYLPGALVLAHSLRDAGTTKKLAVLVTLDGVTADAIVQLKTVYDYVLPVPRIRNDKPANLYLMNRADLHSAFTKINLWKQTQFSRIVYIDADVVAYRAPDELFDLPHAFAASPDIGWPDIFNTGVMALTPNNGDYHAMMAMAERGISFDGADQGLLNIHFKNNFHRLPFTYNVTPSAHYQYLPAYRHFQSSINMVHFIGPDKPWRAGRSASYGSAAYDEMVGRWWAVYDRHYREKEISQLANGGGNYNQAYESQKNASLADIKFDTPAGGSGFPSQTPRQIFPWESHQPKPTRSFYGDEPELQAQTPARAAPAAKSTARSSVTKSPPKSPASRTSENKSEAGTGSWTTYSRTNAWDGVPGISKYADAVEKHHRSNSRGKEGEEGDDDEEDEEARGFKKVTDFPTETERPSLPVTPAPVPRGRDSTGKVLPAAEGVPPQSEWMSLHICWDPTAQLEKLAQQQSAMLLRKLGGHKEGLSGGVSQDAPTQSAGSQTRIAQSAPVVLSPRPVKGTAAAATRSLERQMTEEEGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTS0</accession>
    <name>A0A2T4BTS0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTS0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTS0"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="430" mass="48912" checksum="AC4B412D8DC1F979" modified="2018-07-18" version="1">MLSLSNKHIVHALLGASLVFVSLLVYVWNFHLLPGDGFGGHRGGPHDFDHDGMCPRGSRRHGNSTYCVPREIGGVRWKRPSDATKIMGLIFYGRRSTVSILDCYLKRNLAKNGGILDGVIFLQRTTDADDLKFLKKLLASEPAYEKWEIDMSEGGFASSYDRIQDDVLYVKMDDDIVYIEDSAIPSMVTTRAEHPEFFVVSSNVINQPLISWIHWNLGAVKAYLPELNKAYPAPKPGEKLDWRPSMLPSWQGSDDFEVSEWNPPDHQKHRWLPVKGHTDHILDRTPIVETEYDPFGPGWKKWQVAAQEHYSLFENIENDNLRQYRFGTWDFQLKRMGIQFIAMMGKDINLAKPIAADDEHHFAVTMPEQTGRHAVADGGGVVSHFSFGAQAGDERIEQTDVLDRYRAYAEENICKGPMLWDPVLDNHDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU67</accession>
    <name>A0A2T4BU67_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1384211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU67"/>
    <dbReference type="STRING" id="983965.A0A2T4BU67"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016441">
        <property type="entry name" value="Tti1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005250">
        <property type="entry name" value="UCP005250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="715"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118362" checksum="706FB021896095C7" modified="2018-07-18" version="1">METTPAAKERNELFQKLKPCCVQVSQLAIRESGDPKSHRQVLQLVDQILDILNQQISTNPLALDEKLAEYVFFPLQHIFRQLERYPMNVVEECVKCLTILIVHGWKTKISAKLVQQIFSFLIFIIDGIPGSPKRDVPEETVLEAFRAETALLTTAGSSPVAAAGLSEPESIPALGHGITVMLDAVAEGASAEIQHEALRSLEAVYGAIKEHAALASFLPGTISSLAKVLSKPSRYKKLVLARCLETVRVVLTRVLSDMRTRSIFAKEAESQSDADKSRVLSSAWLKATVAQVQVALSVMLKLRTHQAAEVREALRRLCVALLDECHTTLANCTTILIETSVILDKGPDEDSMTETNLRYLINIYPELGESVKSTVYNWMSSLPRLVQASDERIKEQAVYNLTKGIELLRSLRIESSTLDDSISSTLRESLMAVVSATKEQQTNAGGRVLLLDDGSSASAASSQSDFQPVILGHEGQRRLKSEIMSLVRTVASTSQHTKIAANMLDCIRDSASLSQLTAYWLCFELVKASHAASEDTDALLDLSAFTDQSDDMNQVFDELYDFSVQVLDSHTEMAQVDWRLEVIALEIMAYAAQRSGESFRPELVDVLFPVATFLGSENANLQQHAITTLNSIALSCRYPNVSELIIDNVDYMVNTVSLRLNTLDISPASTQVLRMMVRLAGPRLVPFLDDVVESMFSALENYHGYTSFVESLFSVLKEIVDQASRADSRLLTDAEMTSINHKKTAQQMENLDMLLETLDRRKEREERDRAEMEGLEQIDGHLRVPWTSGSAQGQDEQNDQDQEMPPPEEEKKPNSPTYQLLQRVASLTQHYLTSPTPTLRRSLLELVTTASSVLAADQDAFLPLVNAIWPVIIARLHDPETFVVIEACEALSGLCKAAGDFLSTRWKTEWWDGLGNWCRKVKQQASGNRARTNAPSKNLSQSLPVRDIMIPGRLGDDGFQITTKPVGDQISSGGGGLGQYASPIRTWESVVKLLTAIVSYVSVEDDMFDEILELLAEAMERDRDVRDALEVINADAVWVVRYERGLVEWAPAPVMEGVVFPEMEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUR2</accession>
    <name>A0A2T4BUR2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenine nucleotide alpha hydrolases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1404789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUR2"/>
    <dbReference type="STRING" id="983965.A0A2T4BUR2"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="15552" checksum="C7B1527FFE11EC48" modified="2018-07-18" version="1">MSALRILVPVKRVIDYAVKPRVNKAQTGVETAGATQASKIEFGADDAVTVTKEVDGGVETVRAKLPMVITTDLRLNTPRYATLPNIMKAKKKKLDKKTLEDFGLTNEKRLKVLKVTEPPQRQGGGKVEDVDGLIGKLKELGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV19</accession>
    <name>A0A2T4BV19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1340745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV19"/>
    <dbReference type="OrthoDB" id="4897481at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="117" mass="12529" checksum="E8238EB775288186" modified="2018-07-18" version="1">MESIAVEHQYSRTPPRSSTETSMASLPHQEPSEKRELPHHPMLSTAALLNPIIEKSPPPLVAEPVPLHSNSRPQAQSLHSQSSSHSNSRSPVDMAPSASTTPPREPINGSAMDGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV84</accession>
    <name>A0A2T4BV84_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1000-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1362473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV84"/>
    <dbReference type="STRING" id="983965.A0A2T4BV84"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000003">
        <property type="entry name" value="DUF1000 domain protein (AFU_orthologue AFUA_1G09230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="226" mass="25183" checksum="066079F3FDF7E1E7" modified="2018-07-18" version="1">MSHHCHDEHDHHGHSHHDGEHDHSDDITPALQSSLYEQINFDEITTLNEARRDAGKEIVRKTWAERLSAQPELESDADEQLLMTVPFTAQVKLHSILIRTSPSPSAPKTLHLFINRDNMDFSAAEEETPVQVMELSQTSEVQEIPVKRALFGSVQRLVLFFVDNFSDGEEDVSRISYLGFKGEWTRLGKAPTNIIYEAAAQPGDHKVKGTSVNEMGSGIGGRGSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVD5</accession>
    <name>A0A2T4BVD5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1340296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVD5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVD5"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="36"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="424" mass="47663" checksum="CB47729BD991BC37" modified="2018-07-18" version="1">MSGSLKLKPAARVSGQKQDVWTIVNEAAAASPKQPIVNMGQGFFGYNPPKFILDAAKEALDRVDCNQYSPTKGRPRLKQAIADAYAPFWGRRIDPDREVTITTGANEGMLSAFMAFIEPGDEVIIFEPFFDQYISNIEMPGGKIVYVPMHPPATGATKTSSAADWTIDFDELERAITPKTKMIVLNTPHNPVGKVFSREELQKIGDLCVKNEIIILSDEVYDRLFYVPFTRISTLSPEIERLTLTVGSAGKNFYATGWRVGWLMGPEHLIKYVSAAHTRICYSSVSPLQEACAVGFERAEAEGFWDDAIRDMKGKMDRFNEVWDELGLPYSEPEGGYFVLVNMAKVRLPEDYPFPPHVASRPRDFKLSWFLIQEVGVAAIPPTEFYTDENAHMAEDYLRFAVCKEDAVLEEAKARLRGLKKYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVD9</accession>
    <name>A0A2T4BVD9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1078011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVD9"/>
    <dbReference type="STRING" id="983965.A0A2T4BVD9"/>
    <dbReference type="OrthoDB" id="5236816at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="508" mass="56455" checksum="8E842274CB95619C" modified="2018-07-18" version="1">MAFSMFSQGSFVAKLRGLVDDMTSSPRSPSKSPSSSPEDNGDKIVETPSITPPTTQRPRKLKSPPSQPRPPLPPRRRRIRRPEKGSLRDILRQHAGTALFMRPICWTDLHASLLGARFCELAPCDTPQPCDLPGPTPSQGHIQPSDTITRLSEALTEILTPLSPVAKPTSAAVRVILSTLWPAAFSTSYTTPELNMYYGEKVYFDAVRTQALWNYPPNPPTLSSQSSTATIIARPFDSHGSLASTATAHSPANLPMLCYIGKQQLATIRQHLFRVGTGPDAKPNLPVMRLQRLRAKQLVPTDSDEDAHFVGIFLAMAQRHFYTTPVKIPREGYWPPREGRWSPREGKPPRPNFQDVKLRILTHDNETCEFLVYTGYVTAKFLDRFYDPSCAPLNEDGNVEGMKIEFTRVPIWPILGLRERLGKALGEDIVGPFDPTKMETWEFDGPRPEPRSQDSDATVATVVTSKRKRGSSPSSSGESSEEESDEDDADLPEKRRCLSEESRVGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVJ8</accession>
    <name>A0A2T4BVJ8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1404357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVJ8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVJ8"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22170" checksum="A9695E2B2C4A0240" modified="2018-07-18" version="1">MVTNAILGGIADTVAQTITAVRERAVRKPGGVTKDDSFAIEIHELDEKNPFLDRDLIPDSMGLPPPFDFERLTRFMAYGFCMAPVQFRWFKLLEKMFPISKGSAFVPAMKRVACDQLIFAPFGVGVFFTAMTIAEGGGRRAVAHKLRDMYIPTLKANYVVWPAVQVINFRLMPVQFQLPFVSTVGIAWTAYLSLTNAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWM0</accession>
    <name>A0A2T4BWM0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1338588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWM0"/>
    <dbReference type="STRING" id="983965.A0A2T4BWM0"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40747" checksum="201ACF212F0FE5A8" modified="2018-07-18" version="1">MPTPSSNPPPDQSSPPPYSFSSCPEDQPHGSRSSRPTQDTTRPTSDMETSQSSSSSIASTAYSSAAARDGPAAEEAVFIDGRASVGVSPIDTTSPRPPSSGTSATSPTLSGRDDSLKHQGTDTSDRLSRESSTVSGHSHVENPIPVRREPDALEWYEEDAYGSPAMPSDCTNLRKIPISPSSFLRPGSRFRGTQQSERQVYEVQVEIKHVDLRESFLCGYLRIQGLTEDHPTLTTYFEGEIIGTKYNFFTKHEDWGANSKVDLSHWSKFGAFRPYQKMARKGPVTITDLAQRDHIFMRWKEHFLVPDHRVRTITGASFEGFYYICFNQVKGEISGIYFHSKSEKFQQLELKHVPDRGCFSAMEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX50</accession>
    <name>A0A2T4BX50_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1404023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX50"/>
    <dbReference type="STRING" id="983965.A0A2T4BX50"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="602" mass="67521" checksum="AADDFBD12ACC7BCC" modified="2018-07-18" version="1">METIDCVVAGAGWYGLAAAKQYRVVSPNDSLVIFDPQATVGGTWADERLYPDVKSNNLLGTYEYPDFPMDPKTFGIKPGQYIPGEVINAYLKAYVDKFNLGPCLRLRTKITAAEHHDTAEGGWTLTVVNDEGHEYKVFARRLIVATGLTSEPFMPHFDGQEEFGGRIFHSKYFKQNRDTLETSKAVTVYGGTKFGWDAAYSYAMAGVEVNWVIRSSGHGPCWIAPSYVTPFKKWIEKLANIRFLTWFSPCIYSGAAGYTSIQRFLHGTPIGRALVNAFWAILGGDVLSLNNYDAHSETAKLKPWTPAMFTAASFSILNYDADFFALVRDGKIKVHIAEIDHLGPGTVHLADGTSFASDAFVCNTGWKTSPPITFLPAGIDRELGLPHAIDTEAPPEDLANQQDLLRRADADIAARFPRLRDQPVWNKHYVPLTQQKGISTADPLNPYAPQTPFMLYRFLVPPSERFLRPRDVAFSGFVSNFSNTLCAHLQGLWIGAYFRGLLADDLLRRALADDGDDAMRRLRYETVLHNRFGKWRYPTETKAPTTIFDAVYYLDLLQKDLGLDPRRKPKGFLTEVTSPYGAEDYRDVNDEWESKVGRVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX77</accession>
    <name>A0A2T4BX77_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1404056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX77"/>
    <dbReference type="STRING" id="983965.A0A2T4BX77"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="232" mass="26498" checksum="7F1AB2051AFEF0D8" modified="2018-07-18" version="1">MAPTLAVSMLAKRQLARAPASSASLMMATRMLASPSVFQQQQQQRGYATPKGAPPQNFRMSKKTEWVWEKDSLLDRLGKYFLMTEMARGMYVLLEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLSNGDKWEPELAAAIRADSPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXP1</accession>
    <name>A0A2T4BXP1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_43230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXP1"/>
    <dbReference type="STRING" id="983965.A0A2T4BXP1"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="176" mass="19158" checksum="0F8BB5AA8E409D44" modified="2018-07-18" version="1" fragment="single">FPPFEPIFTLLTNTTTNTTVHPRVHYLFSDDDASAIFTAPQTTTDPLQRAIVVDLAPPSAPNGKWSVSWASSLTPDFAVTSSQLSLQQHGSGTTTSVMLRVEGVEREPVSSRPNSLPASGSGIVGRENVEQLVEEFRRRMGVLKKVVDEGERRKEVMARMNEGVHSEEGEGARGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY14</accession>
    <name>A0A2T4BY14_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1403573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY14"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39803" checksum="5B540706ED57D4FF" modified="2018-07-18" version="1">MNPEPASPKRRHILSSINPQQSSDKEHREVTPRDDVKPAASVDGDDANADTTRPRRSRLRLKGEKKRRHRSRSSERDAESGRHRHHHHHRHRHRRRRERSPTPPNPYDPPPLDPDAAFRESLFDAMADDEGAAYWEGVYGQPIHVYSDDKVGPMGELEKMTDEEYAAYVRQKMWEKTNAGLLEERARREEERKRKREEEQQRRKEDRKSRKLHDEMEASLRRAEERRRSRRWVDAWDAYTKAWAAWDGTLEKLAWPVLSGQRKDVSEEAVREFFIHGIGLESVGEQQFAAKLKEERVRWHPDKIQQRLGGQGGSDVLKDVTAIFQIVDKLWGQMRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY77</accession>
    <name>A0A2T4BY77_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1043809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY77"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="56" mass="6171" checksum="1A8C8C903EDC3833" modified="2018-07-18" version="1">MLASYAVSSGPLDDAIMAQPCRGWRSLRCFKVLDFPIGDSGPMARPNARRWVRGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYF6</accession>
    <name>A0A2T4BYF6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1403648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYF6"/>
    <dbReference type="STRING" id="983965.A0A2T4BYF6"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="6">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="371" mass="42387" checksum="8F59EC118FA65681" modified="2018-07-18" version="1">MSDQNKGRIAIKFGSSSTASSSTNKSRSAKPSTSSLGKRPRPHALGGGGDSDASDSEDDDGRRHHHGRHEAITGFGEDGAETKRKRPREEKKEYVIARQPNRNWKDEVKSQRASKNPLPDEARAQQNAVTTETEPASLDTPLKWGLTVKEKSAVSEDKMDVEPPGDDQKQPTTQSDANDAPPPAARTADEEAMDALLGKTPKEQKVISAPVSEDDAYRRDVEASGAVSTLQDYEDMPVEEFGAALLRGMGWNGEARGPPVKQVKRRQNRLGLGAKELKEEEDLGGWNQNGKKKARPRLNDYRREESKRKEGRGHEDSYKRERERERDRERDHYRERDRDRDRDYRDRDRDRHRDHDRHRDRHRDSDRHHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYR3</accession>
    <name>A0A2T4BYR3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1440612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYR3"/>
    <dbReference type="STRING" id="983965.A0A2T4BYR3"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF73">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="279" mass="30844" checksum="6EADFF6F0BC09543" modified="2018-07-18" version="1">MATPAPTAELDALLQTHVSEPIAPEKLFPILSTTPFIPSRTLINARDVGAVPGSKIPPGRVFRCGTLEYAGQDPDTVAWIKGNVRRIFDLRKPVEREHGPDPEIEGVENVWLPGSQEYKTPSLDDFAKGDGSAAWKDQYMAVALTYAPTYKAVLEHIRDRPTEPFLFHCTAGRDRTGVLAGLLHHLAGTATDDAIRDYMLSRIGTEVARDKLLKFALASVGTDDMETPGFYNLVELRPQYWTAFLEGLEEKFGGWDGYVTKSLGISEEDLVTIKNNIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ85</accession>
    <name>A0A2T4BZ85_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1392994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ85"/>
    <dbReference type="OrthoDB" id="4898027at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="288" mass="30679" checksum="76A4AC8A67C35F7B" modified="2018-07-18" version="1">MVLFEHLPLIGLALGFAHHHSGRAPHSHPALPNHRHVPQISADMSPFDQAPKLIASRAAEESHEAAIPVSEAAIPVSQHHLETILERLRALEEDISNMILFKADSSLESKPAPSVPPKSETLAVTTSEPTVAAATAVGGMFMEDSADFNAPDMSTTIVTLTTLITHTLTMMPTSILTLTAFPTFFAEASPTSNVDRTIDAETYQQSKSKAMIPFFNVLASANPPEATTLSDSHDLEVQPLGSLSTDVGAEEKGPEITPLGPGFNASVTYHRVSLSAASSGFRTVRRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0C7</accession>
    <name>A0A2T4C0C7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1463575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0C7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="17685" checksum="B020ABA6224A2FAA" modified="2018-07-18" version="1">MSAYPSIPGLAQSKTCFSMRYHEVGRRNMFRVGDGVGTQLSWSISSRLNPYLPHHLRLSPIASDFQAPRLPLESLPIRIRTSARRQAALAADARIPKNFSSGPTRGRMLRPVTVVREDAYASITLPQVFMSKTLRRMFQAWADTGSPGSSAALGWQSGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1G5</accession>
    <name>A0A2T4C1G5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1402925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1G5"/>
    <dbReference type="STRING" id="983965.A0A2T4C1G5"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="383" mass="43466" checksum="2D5AB026C27056C8" modified="2018-07-18" version="1">MLSEDDLERAACKLSDFRQDSSLSKILDQYAALIESYKQLKSDYEEERDIREKYKRMAQGHGGKPFVLVLVNGDDYDFPEHLVTEWESGGHAAAEMLKNAIMRSPRWKDLDHCEIMVRVYVNMQTWAEVLQDVLDPMNQSISVSAFAAGFNKANNLFDIVDTGDMDKTDDKLRATLELHAASPQCKHIFFAGCFDGRYVPDLAKQTDMKEKFTLIQNPEREPCQDLLELGMNIETYDTLFEAQRITSGTRYGGFALWTPYYPRSTSSSTAFPPDWFSIIGEPIEQRSPLTIDWPQLLAAERGQSKSPSTVTGKRNKGKSSAAPQNAQVKSNTSAKLRNVQKENVLTQVAKESSAMDQQKSQKTCKFFRKYGECRNGLDCRFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1T1</accession>
    <name>A0A2T4C1T1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1T1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="18545" checksum="246DE80C475FD1B8" modified="2018-07-18" version="1">MEYISESMEELRVRTDMEQPRQTEDGRDGAQGKRTGYSFVEVRGGSRPSWRHLRAFYEDAIVAFLRITYFIIRVPIVQVPWADIDVTWIEGRQRNLSISSHLPSSSLDLGLRQPRTYIFSPSAAVRTEAATVRYLIIVFQTPSYIFGLPRATRMTGQAGYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1T3</accession>
    <name>A0A2T4C1T3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_55065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1T3"/>
    <dbReference type="STRING" id="983965.A0A2T4C1T3"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="13">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB75526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="463" mass="51373" checksum="694250BA36903132" modified="2018-07-18" version="1">MVAQDFEAVLKGKYPGKAHASRVVDLIRKKDPNANGVLYLEGRMTKLLEDNDSPEPFRQRRYFYYLTGCNLADCYFTYDIQAAKSTLFIPPIDPEDVIWSGLPTSIDDALKLYDVDEVKLTTEVNATLAHLANATSNSTIYAINGQVSDHITFIGFDNKDFALLKEAIEVSRVVKDEFEVAMIRKANHVSSLAHKAVVEKAKKASNEMELEAVFLERCVANGAKNMAYHPIVASGTAAATLHYVPNDAPLAGKQNLLIDAGAEWNNYAADITRTFPLNGKFTKESREIYDIVYKMQQECIAVIKAGMYWEDAHVLAHKIAIDGLLALGILKGDKDEIFKARTSQAFFPHGLGHYLGMDTHDTGGNPNRQDPDVIFRNLRLRGQVPAGGVVTVEPGIYFCKFIIDPYLEDPQHSKYIDADVLAKYWDVGGVRIEDNVLVTETGYENLTTAIKEPAELEALMAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C221</accession>
    <name>A0A2T4C221_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1356972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C221"/>
    <dbReference type="OrthoDB" id="4896605at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="20723" checksum="35DB017FE823BE35" modified="2018-07-18" version="1">MWAAVQHRIALHLTAPFRGLSESQRKSTSNRCDLQTRELATPPLIHLDKGIFFYASCCLLHLVLYFDFVKCDTPLGSQPPEAFYICLMLLFLPHRLYAEWPITSKAFLVSWAHIWSRSRNVAYAGFVFLIITLFLIFCTYIFLWHCRALLSQRVKKSPKMSRALLWFQRLGEKHVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C272</accession>
    <name>A0A2T4C272_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1439357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C272"/>
    <dbReference type="STRING" id="983965.A0A2T4C272"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="390" mass="43682" checksum="012AC199C5BBADA0" modified="2018-07-18" version="1">MTLRRAGGLGRQLASYATVASRASIQPIAHPPGSGIRFGAVVQGVNVDRISDADFDIIKDALYKHQILVFKAQHDASSRAQYEITQRFDPKATASYGHGKTLDAKRSILHPDLKTIPHQPQVQVIGNGFVEEYEGLKDIQLRHPHHKTFHATVIPEEDDLDYTRFYRWHIDAALYGLAPPVATTLFAARVPHGRRQTIRYEDTGEELDVPLGTTAFASGYTMYDLLSPQDQQFAMTTKVEYAPHPYVWMSGAKSRSDGLGLLSEGKEAPLDSLPEIEQDKIQILPMCWRNPQDGRLALQVHPSAVRKLHLAGGKVVDDLKEVRETVHRLQRPGIAPKYVYAHDWQEGDFVIFHNRSLIHSVVGAFAEDEVRLFRQCNIAGSSLPEGPRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C297</accession>
    <name>A0A2T4C297_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C297"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015562047" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14460" checksum="79003174D42E1CD6" modified="2018-07-18" version="1">MAQSLAPLRWNCGLCPCSSLSLALAAHWSIAQRSAVLRAWCCSVALYALAEAKAPLIWGTDDCQELRPSRDEPLLRLATPGRKANLANIMFLKTNATGNPPAIAQIETHSEDRNLTTSGGHDICILHVTLLPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2P9</accession>
    <name>A0A2T4C2P9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1262526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2P9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="141" mass="15120" checksum="CD7EC23556660C82" modified="2018-07-18" version="1">MFPANVAPEPVESTAIRLTCWLGTLQRTRPSHTPLFASPSYGSFPLAHRLSVAHGRACPESAQTSPLPYPGHAEPSIPHAIAFALVLLLPLSMLVCPIFIHFGRFLLLVPMAGCSHPFHASSCPAWGPHPPRLQSAASISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2X6</accession>
    <name>A0A2T4C2X6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acid phosphatase/Vanadium-dependent haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1422970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2X6"/>
    <dbReference type="STRING" id="983965.A0A2T4C2X6"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="98"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="540" mass="59452" checksum="89598F2C2928196C" modified="2018-07-18" version="1">MSGTRRDAPPHHNEAPPDAGLRSLDHYKKALPKWRYTLRHQALPLIRWETPYLAALQAKLRTPALDSYFAITANLGTHTFFMIFLPMLFWGGYPAFAKGLVHILALGVFWTGFIKDFYSLPRPLSPPLNRITMSGSAALEYGFPSTHSANAVSVAVFAVLQLRSPDNPFSDTTKLLLEILAYFYAVSIVFGRLYCGMHGFLDVIVGSIMGAGITILEYYYGPPLDTAMQNGSWLVPFITGLVVVIFVRIHPEPADDCPCFDDSVAFAGVVIGLEAGTWTVGRTFLAQAESSMGALPWTWCVIVARMVVGIVAIFVWRETMKPTLLKVLPHVFRLIESTGLDLPRRFFTPASEYKSVPPGSRLDTLFPTASDFPRMVESIRHPTTRGRSVSIGPQSVADAYETLAYRERQRRDSISSNASLKSKSSNLDLNGTDEDKSGRGAQASGAQKLVYSDNNPSSSVVPGAQNGNPDIYITMEDARDEKEVFSRLVKPRVRYDVEVVTKLVVYGGISWLAVAGVPMLFSITGLGVVRTVIRWDAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Y6</accession>
    <name>A0A2T4C2Y6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1334993</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C2Y6"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="45"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1802"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2077"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="481"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="710"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2200"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2222"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2247"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2276"/>
            <end position="2288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2337"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2359"/>
            <end position="2370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB75927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2384" mass="262733" checksum="04CC30B33DDC613A" modified="2018-07-18" version="1">MDGPALVPDDVLDPLPPPPPRLFERLRQIAGYSWDETEPPFHSTYDFWHVFGTRYVSPVLPTSSSSQNASSPGSVSKLQSGRPTPSEHGGPLSSYSFGYGSESPASPLPTPHTNTPHTNPLASPSADATTYYIEEPVVARVSHHALREERAFQIARSVTSADPNGDHIVKPLDLIRLSPVVGDRGAIVVAIYQHPGPNLLLDLMDMGPAFYHARKDGDAYRAYYCRPKLHPPISLRLFLDFAIGATQCLEILHHSRGMVHGEIRGDAFHFNADENKVRVMSFGSGVRSFENGLTSTGWSMLSKELGGRNKLLFISPEQTGRMPAEPDTRTDIYSLGVVFWTLLTQQPVFTGDSALDIVQGVLGRRIPNVATVRMDIPDVIGRIIQKCTAKNVADRYHSASGLRHDLINIKELLEDGNSQALKEFRIGTSDVSSFFMLPTSMIGRQEEKATVLKVINRVAKSHAALRKGPVSRFSDGASLHEGTTFDDISSEGGASSIDGNNRRSGSFAQTISSETKPSRNSFYPPMISETMTLSTDTTSSSQSTAAAFPRFTKPWERWERNQSISLGSLSMDSSSMVESLNVEGSRGPLDMGSSSLSRQLGSSKFRRHGHCEVITVEGAGGVGKSLFVQSVLADARRNGYCATAKFDTSKRTPFGPLLKLLSSLFKQVWGERNTDTPFHQGLKQYIRPVWPMLHRILGLPEFLLGSPDMNTARPISSSQSSGSRKDARPPLKRRTSSPGLSPGPLPRSGTQSSQDYLRAGTSTKSMRLINTILDVLRVFTTHKFICFCLEDLHFADDESLELISQIIAARMRMVVIVTYRPEELSPAKLQAVVQPLDADGDYGALRPALLDADTVVEHPRSARTQVTRIVLNPLSEDDILHYVSATLCRPRDEILSLALVIQSKTAGNPFYMREMLSACHRKRCIWYDYRDSQWHYDMDRLFAQFQGEKDYDVLDTAFITHRLGELPSAARAVLAWAALLGGSFSFELLCRLMSGEFDYPDDDEEEEDSAACPNNAPAYVLQSRIYAQSGDSPAALVSLKESLGLLGISLEEETTYEKCDEKFHKIVARIQDMDRQALLSNKKSSDPSIASIGAVFAETTNAAWWSDRLQFYHLSLLMFDTHDSRGPFPQSGMVFLNLSVIALARFNMVPFAIDMSMLSQDLLFQTRDAYSLARGEMLHQCFVGHVHCSMTLAISQMEDAIELASVAGDRMSTIHSYGLAAQIKFFASENCNDLEAFCELACEEIYRWNCDSRGGVMLIAVRQACRALQGKTRTHNALEVMTDDEHNSALYKKWMVERTKGSNRPMLFYESFEIVILFLFGHYDRAVEVGERCFEQLADLWSARNTRMIVFFYGLALAGRLLAKMEDPRSQAGDFTAEIAQLIEKLNVFLKMINDWATVSNVNYLAWARLLEAQMAELSGDHGGSVQSYEEALDHATEHDFVLEEALGNYLMAGFFIRRKARRSARAALLDALSLFRQMAATGVAHAIEDAHSLLLHGPTRNHRVADMGVQTDFVTDAPSVQYRPVDGDDDDDLTQIPSNALTESKGEQIGAWRNSMHMQAEDGGGLPALDMIDLHAILKSSQVISSLLQVEELLKTMCDVILQTCGGSATSAAIVVDADADGWCVAASGDPEKGASAHKPALPLASTPLIAENVVLYCTRFMESVFIPDIVSDERFGNVSESWLQRNPTSKAIIAIPIRHANKPLLGVLYLEGVPGSFTDRNVTVLQLLVNQIGISYSNALSIKNIEKISAENHSMVEMQRRALKKAIEAEAKAKHAEAEAKRNVKLAEEAAKAKSIFLANVSHELRTPLNGVIGNSELLRDSNLNKDQLEMADSIRVSADLLLTVINDILDFSKMEADKMKLYIIAFNPEEMVREVVRAVSYSNREKTSKKNVKIIQDIDLPSMLIYGDPIRLHQVLGNLIGNSLKFTEDGSITIGARLDHETQERATLTFWVRDTGIGIPPEQLANLFQPFSQADASTARKYGGSGLGLSICKSLIEIMMQGKIQLESEENSGTTAWFTVSFEKAKPDVAAGDAQLQTSAPVDRYAARTSSFVERAASPNPYLDLTRVPKEEIRICVAEDNPINQKIAIQYVQRLGYTSVSAYENGLKAVEGLRQKAREGIPYHIVLMDVQMPVLDGYEATKLIRSDPIDEVRKILVIAMTASAIQGDREKCLAAGMNDYLAKPVRAEVLKRKLDAYMSNSRPGPPPSTPSPANATPYADTTNGYSSETVTSVQKLPPPPRKPLPSSASSTSSEPVIRKPVPIRSGSASLHESLFDGPHDSEDLQHPGSPIFDEELETPFGDDSIASQADTKSRSTSRTSSDQEFSDSGARRGSISQGHTQQPRKLAKSRGNSTTTEEKMENGAGEEKGEDESQQSIIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C351</accession>
    <name>A0A2T4C351_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1423038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C351"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="31567" checksum="4BA672C26C42D36F" modified="2018-07-18" version="1">MAPTYDDAPQLAEGHDLPEAYVSHPHAEQVWSPQPSIAPTYISQPSTVAYSNNNETYPDANAGVYGTTGPYSDAAKGAAVGGVGGVTGAPAGGDAAYAAAPPESTVPPGKKTAATVCGISLVLLLSIIIAILSAAVIGLAAGTGVATKNYNDAHSQLQVLSSSLAVAQAEATGTPTASAPLPSGTPDFNNITNGCSDDPDSVTGNIYTSKFFGKPHFTMYCNKDTVNPSMFSVFAPDFNGCMDACAAWNSYNKTTKGSCVAVSFIPAWSSVAVAVAGNAPGDCYLKPGPQTKANLTDPNIGTECHAALVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3C7</accession>
    <name>A0A2T4C3C7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1746-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1391618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3C7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3C7"/>
    <dbReference type="OrthoDB" id="5428737at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="82"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="358" mass="39785" checksum="E93CCF18D197AE0F" modified="2018-07-18" version="1">MNHDAASTSSARIHDRLSPPADAATAGADDAEADADPRHRPESRQRSRSSNGRQRRRRRSKKKQNPGLAKKLAFLTHLLKTLDLVFFAELSSLYYMECSIFRFFLRAAPQYMYLTPKDESFALLMPATQLHVILVVVPNLLCMALHLFGSLPTGPEYHRGYQHGGMIIDFIGQMPAAYRLYYLLADLFILFIQCLMLTIHNQRESLRVALKTFRPLISEMVLEPIAPRSPEDLDAEERGVSRHAPGLMINETDEIELQQIGRPGDGDGPEERNEQSGYAAGDSGDEPPRTHLSDIMSSGNAVLSEYHIIHTMRNAAMNTGGSTALSLQSIGYRATMASMQGRRRGATLQNSLVPPPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3G0</accession>
    <name>A0A2T4C3G0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1376949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3G0"/>
    <dbReference type="STRING" id="983965.A0A2T4C3G0"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="200" mass="21817" checksum="8130DCE5F97D2724" modified="2018-07-18" version="1">MFCARCFRGAAVARRQLPISRHAFSSSSLRFYSAAEPQLSTPATDAGDASKPGSATTTSSRSICPEGTVLTGLNYIKGGQDPVALKDEEYPEWLWSCLDVMKKADAADDNLGDEFSKSKKQRKLAAKRQKALEAKLLAEGNLEALAPKVPLPKQSVNLPGDKDGSVLDNIAAAEKREELRKAMRKERRAAIKESNYLKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3J5</accession>
    <name>A0A2T4C3J5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1401546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3J5"/>
    <dbReference type="STRING" id="983965.A0A2T4C3J5"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="117"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="517"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="695"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="330"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="793" mass="88073" checksum="02834E9E27557CAE" modified="2018-07-18" version="1">MQATRRQVLSSAQRLAGATNRLTRPVIARSALRPILLSAAPSARILPIPLVRTYANGRPNPPGGTHRMNMGGGEQEKPALEQYGVDLTAKAREGKLDPVIGRDAEIQRTIQILSRRTKNNPVLIGNAGTGKTAILEGLALRIVRGDVPESVKNKRVISLDLGSLIAGAKFRGDFEERLKKVLDEVQKAEGQVILFIDELHTLLGLGKAEGSIDASNLLKPALARGELQCCGATTLAEYRVIEKDVALARRFQPIIVSEPSVEDTISILRGIKDKYEVHHGVRITDGALVAAASLSNRYITDRFLPDKAIDLMDEAASHLKLQHESKPEEIMKLDHKIMTIQIELESLRKETDIASKERREKLEQDLKKYKDELSELNARWEKERSEIESVKKVQEELDRAKFELEQAQRSGNFARASELRFGVIPDLEQKLPSDKEIQQSSDNATLIHDSVTADDIANVVSRITGIPVSKLTSGHIEKLVHMEDILRESVKGQDDAIKAVSNAVRLQRAGLSGENRPLASFFFLGPTGVGKTELCKKLASFLFSTESAVVRFDMSEFQEKHTISRLIGAPSGYVGYEDAGQLTEAVRRKPYAVLLFDEFEKAHRDISALLLQVLDEGYLTDAQGHKVDFKNTIIVLTSNLGADILVGQNHLHPYKEDANGDIDPSVRQAVMDVVASAYPPEFLNRIDSFIIFKRLAKSAIREIVDIRLKELQQRLTDRRITLSVPDTVKDWLAERGYDPKFGARPLNRLITNEISNGLADKIIRGELKMGQTAEVKLRDDKEGLEIVNVSENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3M8</accession>
    <name>A0A2T4C3M8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3M8"/>
    <dbReference type="STRING" id="983965.A0A2T4C3M8"/>
    <dbReference type="OrthoDB" id="2014654at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="392"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="596" mass="63787" checksum="283EBEE685B8A9F2" modified="2018-07-18" version="1">MPAANANVVTLENLSEKLPPWRPDGENHLFAVVDMGSNGIRFSITSLAPPRTRLLDPVYTAREAISLFDALTLSADGLVFPAATIESVASAIARFHSLAVSHDVPPEHIMVLATEAMRRAVNAPDMLDAIAKATGGLSVSILDPPVETLLGAVMGSRSGLGGVPGGALFLDLGGGSVQMTWVDTSAQDYEMEAALAGGSLPYGAAKLMRVLQENPEHVQAEETAKLRDGLRDLFARLCARFPALEAIRAANETGEEQQQQQEKPLVDVYMCGGGFRGYGSMLMHDDPISPYPISSSNTYAVRGSRFKETARMLQLNASHEGKIFGLSKRRRQQFPAIVAVVDAFVQAVPYLGWVTFCGGSNRQGALMMKLPREIRESSPLDVLANLKDDAERQVFQAILSKLADSLPPDLTPAIPTIFTTGSGTLFVREIWRRSGHDADANSSFALHDAVSRDTDCPGLTHLVRALLGVGIAARWGGGLGPLDALLHKGLQGILDDRAAGAAFWAQYLGAVAGVLAAVFPVLPRLASEIVGGISFESRVEQRKGKKDRLWVKIGLASEYARGINEEDLIDRINSAAKLTANKASAKAISAQIVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Q5</accession>
    <name>A0A2T4C3Q5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_315832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Q5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="179" mass="20017" checksum="0B0D1F3287C2F45A" modified="2018-07-18" version="1">MYSHYSWFYAWVSRSRFPPRLLRLLRRGVLFYPRLTDGESRDQEENSEGGMQADSRHRPSMWHPGTDESGGAMGSVKFDNTVLFDGGAAAKYCPMSYRAAEASGTCYTDAVDLDDSNFGSASVQPRYRLMLCTGAHDWALEHSPEASTVLLCLCLLAPEACVHRCTWSLGGRVSYVQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3W0</accession>
    <name>A0A2T4C3W0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mannan endo-1,4-beta-mannosidase A</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1401669</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3W0"/>
    <dbReference type="STRING" id="983965.A0A2T4C3W0"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015445135" description="Mannan endo-1,4-beta-mannosidase A" evidence="12">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="399"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="436" mass="46951" checksum="1B3ECF8609A795D8" modified="2018-07-18" version="1">MMLSKSLVAAATAASALAAVLQPVPRASSFVTISGTQFDIDGKVGYFAGTNCYWCSFLTNQADVDSTFSHIASSGLKVVRVWGFNDVNTQPSPGQIWFQKLSATGSTINTGVDGLQTLDYVVKSAEQHNLKLVIPFVNNWNDYGGINAYVNAFGGNATTWFTNSAAQTQYRKYIQAVVSRYANSTAIFAWELANEPRCNGCSTDVIVQWATSVSQYVKSLDANHLVTLGDEGLGLSTGDGSYPYTYGEGTDFAKNVQIKSLDFGTFHLYPDSWGTNYTWGNGWIQTHAAACLAAGKPCLFEEYGAQQNPCANEAPWQTTSLTTRGMGGDLFWQWGDTFANGAQSNSDPYTVWYNSSNWQCLVKNHVDAINGGTTTPPPVSSTTTTSSRTSSTPPPPGGSCTQLYGQCGGYGYTGPTCCAQGTCTYLNYWYSQCLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3X7</accession>
    <name>A0A2T4C3X7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dna2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1401707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3X7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3X7"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="10">
        <location>
            <begin position="98"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="201" mass="22345" checksum="BA722D83BF828061" modified="2018-07-18" version="1" fragment="single">MATTPRAKRTSPRKMKTPKKLADIEDEFDDAFDGDVDFEAVEYAATQAVQQRNSASAANKKKIKTIQRYLVTSVLDGEYVDQYNRTCPEKILLIQADGSKTTRTVQLRGSWFDTPAHAGAYVHVIGEFSFKGQCIVDDAQNLLILHPDQLISATVVADSFGCMRRAVLQDRVKATSEASPPLVYGTMLHEIFQEALLANNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C468</accession>
    <name>A0A2T4C468_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_319325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C468"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="14561" checksum="378922A3733E0583" modified="2018-07-18" version="1">MASQPVLASSPPESVKSCLFSSYSLRTEYLSSVPVSLRTASPAQSRGTRRVLASSTPVQARPLCFSPSLMQLAKSPRHSISSYIFFLVFLLNFYSFIDIISASSPSSLLTSRSLIGKAGVVCILCGQRPHSLGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C493</accession>
    <name>A0A2T4C493_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1377435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C493"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="84972" checksum="2AD29098D05A4811" modified="2018-07-18" version="1">MAVVAMVTSGDRRIYALPGQLADVEKIFGGEYGSEEDEDGESSSCLTDVFWYFASLNRELLTSMLKQGGWWSSMLSILSPMRRAPASSLSREAIMSKWIARECSLLGEQQHRQQHRPAFVEVGHTDFSAAVPGCVPGDLHGAMSFTVSLCGRFLMAVHGRVVYIYELNHVCFPERLRWALPIRRRQGMPLGLLRPVTRILCPRRVISCSMDASAERYSVAFLMEGRVGMVCDIMVERTGTSSPSTPWTDEGAAAGEYGADASFASNFDVASSSASASASASASSSASAASSSASCVCQDRLPCLPLPLEEGPRSVYRNVCHPDDPPRSVAICPQRKCVAFGCSAGIELHWVDAMTGQDLSRWFPLTSPSDFLYFLPPRRGVDTPRKLRLISSAAGLGGPMDLLEGLVHGFSTSLLGTGSSAMVSCLDADSWYLRHGRDIYLEASGSNSRANENDDGHLLSRNVPRDSPLRRLVAASVDHFRAVPLSDGYHILFTDPRTGSLCLGTDAPVGSLTRLLRKLWFRPPPQAHSPVPLLYTAGADTRHGVRVVATFAAARRGDEETDQQLIVFYTVPPDMFHDIRRTDGEARSAGYRPRDDHGFGRPESRYGVVDLLNDPFGDDRPYPVEIHGHVVAVCGNLTEIALNSSPDLVIWAFAAEGWAKAWALNTGRYGRPFRTSAQRDGSIRQVDADGDVLMTERAHPGGQSLGLTSLDFNLFDGAHVGDFEDEDPPMAQGPYCWGKKCHVRGQIWEMQDDVADALSIDMIEEVGSITRVNVELMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4E4</accession>
    <name>A0A2T4C4E4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1356366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4E4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4E4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="7">
        <location>
            <begin position="578"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="760" mass="85249" checksum="F0E7878992C2CC3D" modified="2018-07-18" version="1">MNISFYRGLTRSMSKSVCIVGAGPSGLVAAKTLLHNAPKGHFKVSVFDSQAAIGGLWPTAKTDSGRLVHPLMVANQSRHTVQFSDLAWDDDAPQFPRAWQVGQYLERYRSRYLDGHPDFELQLKSRVARAEKSKDGTEGWRVRIQKGDGEETRDFDYLVVTSGYFGKPIIPDCFKKAKTSVPIIHSSQYRDLKGLLGEGKPNGGKILVVGGQMSGVEIAGTIASHLSSAINSPGESGIAGIDKYSIYNAIQRPIWVFPLFTTPEPTFAAAPFAPLDLGSYNINNRPRPLENTQGHINEEHANMVHTIFESSLGDQEQFSPLLMPNEQERNQPAYLAVSDWYMDFVRSGMITLSSGKVVSLEDDLATLDDHGAQIDDVAAVVLATGYDPSPCVDYLPEEVLATLQHSPRHCNQALALAFHGTHHPQVPNLGFVGFYRSPYWGVMQMHARFLADLWSGPTGERLEALQRKLQADDSIKRTISLRDDPRLSQFPMGDYMYLMQEFSEALSIPMHESIMPKTPTTSRNNLPLDPLTPSRYPSPSDSPDAKAEAEKSLKQVRDLTVECLMTPRFVARGVFRSLLGTWRLERDLTSRLPSHPSGKFVGTAQFLLRDRTSEGLQCASDPNSTDTRREDSGGEDLEYLYIEDGEFQTTSGFGFKATRRYIWRYDSKKDIISVWFAKPDDQKRADYLFHEIEFEAPPSDPKQREKKGWKAKAGHLCIDDYYNVKYDFSFKAVNLATWSIEYTVNGPKKDYTIHGTYERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4N7</accession>
    <name>A0A2T4C4N7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4N7"/>
    <dbReference type="STRING" id="983965.A0A2T4C4N7"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="17654" checksum="78FA98029283B90E" modified="2018-07-18" version="1">MGCTTRINARQEAIHALVRYADGLDRGDAAQFESCFAEDATMDLSPFSVLGMTYEPIHGRAAITAECMKTVGKTLETTHSLTNFLVTLNEQCDSASITCLSEAQHVKKGYEFDVESQDSALIVKCRYEATVAQEGDSVWRIKSFKLTPLWSRGSKSIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C571</accession>
    <name>A0A2T4C571_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1391246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C571"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="17126" checksum="96CFA7FF8B1F1168" modified="2018-07-18" version="1">MHVQTLQLQRGRHQGPRTVPVLYFAAAVPCCKRTCNLPKAAGPVSAIPNGGFEKSQRTETELTVKTVPRKVKIRSKHLESTFRWFTRTGTKSSHLHGVNVQYPQVTSGRLKQQQQQHQMGNRRHEAHLGYRQVGNGSPASKYDAEYLLLALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C574</accession>
    <name>A0A2T4C574_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1299273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C574"/>
    <dbReference type="STRING" id="983965.A0A2T4C574"/>
    <dbReference type="OrthoDB" id="4870803at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="18663" checksum="E66EE70F50923793" modified="2018-07-18" version="1" fragment="single">PVSKRSAPKEEAAGTRRRSGRLSSTQVKSSYFESSSDETEQQTSKPSGYKKSVTQAKKRARDAESESDQEHFKDESEEESAPIQPKKRSRGRPPKKAAKEKSDDEDQYNDVPDDEDDKDVEDEDDDDDDEDGPRRVEIIPLEKLRDTGGVSYEDHKLHKNTMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5H3</accession>
    <name>A0A2T4C5H3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1421888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5H3"/>
    <dbReference type="STRING" id="983965.A0A2T4C5H3"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9578" checksum="F49A5CCE0CBBF506" modified="2018-07-18" version="1">MVSDDFNVLAVDLLNPSAASEAKKHKLKTLVPQPRSFFMDVKCPGCFTITTVFSHAQTVVICQGCTTVLCQPTGGKARLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5J5</accession>
    <name>A0A2T4C5J5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1391385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5J5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015611139" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="15113" checksum="8CA3F5005363888F" modified="2018-07-18" version="1">MPTSPCRLLLLLLLLLTSNPTSPIVNAYGLPPAARPACGCHFTLRLDTLLLSQVLRPSMLLGIVITRHGKQNSAQREQEIKLLALPFNKLNYGGNATTTTLPVGANVKEPKACKRLISRSPAQPSHLWYKATPKRPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5N9</accession>
    <name>A0A2T4C5N9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1236305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5N9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="17081" checksum="479886FA47727CF6" modified="2018-07-18" version="1">MLTVFYDWPQLQQHPSPSSLIMDELCINRQAPSSTIEITYGWQPTPTSSRIAPLSGRLRFRGSHPRRSTAPSRGPPPLHEHLDTMTDFTKPFDLVKAHGIGDVRRRKVAKICGCWTAISCYQLYRYHHRLTLLPKPQTLLSSSSSPESLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6A7</accession>
    <name>A0A2T4C6A7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1355539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6A7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6A7"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01297">
        <property type="entry name" value="D-aminoacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="51"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="558" mass="60277" checksum="C32A8E034E8E8A42" modified="2018-07-18" version="1">MAAEILFESPTVITGDESAEPFVADVLVSGGLIAKIGAPGSIDVPSTARRISAKGHVLSPGFIDMHAHSDLYLLTHPEHEAKITQGCTTEVVGQDGISYSPIRNLDQLRAIREQIAGWNGNPTDEECRTTLSGVGMFEWKTVGEYLDCLERNKTATNVATLVPQGNLRLLACGPYDTPASPEEIQDQIQLLREAMAQGAVGMSSGLTYTPGMYASTSELASLCEALAKDFPGAFYAPHHRSYGFQAIESYAEMLGLGESTGCPIHLTHATLNFSENKGKAPVLLSMIDKSLEKGIDVTLDTYPYLPGSTTLAALLPSWASAGGPSETLKRLEDAEIREKIREAVEVTGCDGGHGIPTNWEEIQIGATGEPSLASYSGRRVSEIAQSVGKPAIEVFFELLQKDKLATSIIMHVGNEENVQQIMQHRVHMAGSDAILHGKTLHPRAYGTFPRYIGHYSRDLSLIPLPAMIAHLTSRPAKRLSVYPFRGLIAEGSAADLVLFDPETIEDMATYEEPKLPSKGIRYVLVNGHVALDEGKMTGARGGKTLRRGKDGRVKARDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Z1</accession>
    <name>A0A2T4C6Z1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1390680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Z1"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Z1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015768080" description="FAD-binding FR-type domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="416"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="651"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB77347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="734" mass="83474" checksum="579A9F83C98191FB" modified="2018-07-18" version="1">MLSRLSYLLCLLFVACAHGAKPLGLEVCGASCYYSFAKIKFASDNVTDQTLCTHPLRITSTYLCLWEHCEEKDLAPGINWWAGTCKKSSKLVNLKEYESTVANVTQEYIDSLPTVEQTQKAVVDVVSMPSEANWNIAHRSVNTYYTNIVYHQKLRWIPYGYWGLVLGLATISHLYALLPVKRSSQPVRKTSAGAKVKGWFHRNLMMAPTFSYHHHQPLGWFAIPLRLQSLVIAGYIITQIFMLAFHYPVFENNIYYKTIAGQVCRILADRLGIFMTAELPFIFLFSGRSNPLIYATGWSYRTFSLFHRWLAMTLVVEGIIHGVVFSAYYVNEKGWEGYREELRDDLVFRYGITMLTALGLSSLFAFAPLRNRVYEFFKATHVAFAAVFLACLYYHVKDQFKGVYLVWVWACVGLWAGDHFLRILRVLAMNYKTLLGKGSLALASYSEETGMIRLQVKPSINCSRQTPGTYYFVYFPGMRFWESHPFTLAGRSKQLDDMPTYNSSSDQPNEKNTGTQSPRVTELPSESGDSYLTFMIRPRDGMTRRLRDKLVSKSESGPLRVRVLLEGPYGTPARLDHFDDVLFIAGGSGITTVLPYLRMFFEDQKQSQPPPPNVRLVWVVRHEGFVRDVLANDLRAIEGAAKLNMEFYVTSEGSNSSTPKTEEAGDSIPDPRFKKSRRPDIHATVDDFVTQSQGKTAVFVCGPAEIADTTRQAVIRQTKKAHIDVELFEEMFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7D5</accession>
    <name>A0A2T4C7D5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7D5"/>
    <dbReference type="OrthoDB" id="4835952at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015766296" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="68" mass="7040" checksum="56A8E5CDA18AE8D5" modified="2018-07-18" version="1">MKFSIMTVFALAAAAIAMPTAKHNTVAKRQTVSDAIPANAPAMTDANGNVIPFVAKDVYVHPAGSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7L5</accession>
    <name>A0A2T4C7L5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prenylcysteine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1438044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7L5"/>
    <dbReference type="STRING" id="983965.A0A2T4C7L5"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015638144" evidence="8">
        <location>
            <begin position="22"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="146"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="558" mass="60693" checksum="7D54FE4BDADBA791" modified="2018-07-18" version="1">MRLQLGPALVAWLSLGGGAAAEGEVKTETKGVRNVAIIGAGAAGSSAAYHLRQYADEADVKVNITIFEKTDRIGGRTLTVNAYDDARHSIELGASIFVAVNHILYNGTRRFNLSTGANYREADSPDDVTAIWDGDGFVYETTDGTAWWWDAGKLWWRYGMSPYRAVKLVKEVVGKFLRLYEGPYFPFRSLSARAYELGLVEVTAVTGEQFLKQHKIDEAFSRHIIQAATRVNYASNLAYIHGLETMVSFATDGAMSVAGGNWQIFDQMVKASGAAILRNTAVSSIRFAKGTSAPSSTPKYEISTSSASAEPEVVDTTFDDVVVASPWQFSNIEAGEGVIKHNIEEIPYTKLHVTLFASPFKLHPGFFNLPPGSKAPSNVYTTLAKDEEPKAGADGVGKTGFYSVSTLRTAVSPKANRTEFIYKIFSPKAVTPQFLSDLLGVQVPDTFTGPAPEAEGSGVVVEPISWYYPHWFYSYPIELPRVTFQDPILGSGLYYTSGIESFISTMETSALMGMNVARLIVDDAAGISREAVPGAVSEEDLLLNRVKVDMVVEEPGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7N4</accession>
    <name>A0A2T4C7N4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-terminal binuclear Zn cluster-containing/DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1438051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7N4"/>
    <dbReference type="STRING" id="983965.A0A2T4C7N4"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="733" mass="79831" checksum="BC41E504D4A2C197" modified="2018-07-18" version="1">MSYPSPGAEALDAGPFYHTGARDETQTHEHHEPEEHQQQQQQHDQHDPTQVHAQEQDHGQITAHEPSSPQQHHLSRPPNLEELRLAAQLGQGLAGTSLLPPNDPGMNVEDPSMRSIMPHPEPDQHQPPSYVHEAPASEHMVPHALPVAVGPPMPPQYSMGEAIPPRKRSKVSRACDECRRKKIKCDAQSDTGDSPCSSCARSSMRCLFSRVPQKRGPSKGYIKELADRIHSIENKLESEGNLTQDEIDRLLTPGNHRAYNGLASSEEPVRKRPFSSISAGDFSTPAPPRQAPWGPEPRPILPAPAASDSYSGPGYTNSSLAPQPSAIRADSAPPKPPVASMESQAIETEEVPDFDEESLHDYLAHVQAIYPILPSSKARIQSLLSQCPSTVRTAFITALQAVGQSSGDTQAASSLLHEWESSEAPHSRAVDIVHAQTLLLLIIDADWRASSQLPFLLGRAVALANTMKLWKFTPIESASETDSDDQLCVRIWWSLVLMDRWHAAGTGKPSQIPDSSVVAPAGLENTLGEVCYYLIRLSKLLNRTAFVISTLQPGSSTAEPAMAAILADYIENYREDLPGHIEAASYPLVHLAYWHCKLLVTLLTPGATPTETLWPTSELATLLLANAHLRSPFTNHFVSLVTMSLSKLSKMDSSREGAVRLMKEILEKPSGGHWDSVREKLTEQLRPTSSVEATASQGLQHLADLATAHEGIAPGSDDITFGPTLASGYLDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C801</accession>
    <name>A0A2T4C801_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1330608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C801"/>
    <dbReference type="STRING" id="983965.A0A2T4C801"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="18820" checksum="920E4CDCCC59B804" modified="2018-07-18" version="1">MSYSLYDATVPLAQNALKALTSILKKGEAAPNGAELLTARIHPDMLPLTFQVKMVTDTTTKLVARLTGTEPHAWEGEVETYADCYARIAKAEEILASASKDVINQRQGETVNVGMGTLGTFAMTGPNYVNGYVLPNIFFHLSTAYNILRKEGVPLGKADYITSFIGEFLTNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C909</accession>
    <name>A0A2T4C909_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1399228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C909"/>
    <dbReference type="STRING" id="983965.A0A2T4C909"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="23792" checksum="AF98F0921DAE80DC" modified="2018-07-18" version="1">MSRALLRSVLELRAPSSRILPRIAPFLQIQPRCAFNTTAPIVEPISPIHHPNNAPNPTGSQVRPLAFKKSHPAEPPAPIDDSVKTLLPLLAAQPGHYITVHIHGFPYLVQEGDQIRLPFKMPGVLPGDVLRLNRASVIGSRDYTMKGAPSIDERVFECRATVLGTESEPMRIKIKTKRRQRRKRQAKSKHRYTILRISELNIKNLDEIEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA35</accession>
    <name>A0A2T4CA35_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rrp15p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1420540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA35"/>
    <dbReference type="STRING" id="983965.A0A2T4CA35"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="311" mass="33947" checksum="650B412C5E6D9D45" modified="2018-07-18" version="1">MGMPNKKRRNDNKSHRPNKKQRRAQAYNSDSEPEEEQQQQQAFDPVNLLDSDDDIHNAPADDGAGADEDASSSSDEEAPVEKKKKATSKKSRSTKSESEPEAAQQEDDNDEEAGEDEQEGESDDDEDDEDEFDLGVDAPKKKSKRNDPTAFATSLSKILNTKLSASKRSDPVLSRSAAAHEASKAAVDIALEAKARRKLKEQKRVALEKGRVKDVLVASVDESGEPEMTTSEILAIEKTLRKTAQRGVIRMFNAVRAAQVQAAEAEKAARKEGIIGAKSREEKVNEMSKKGFLDLIASGGGGLKKTPLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA95</accession>
    <name>A0A2T4CA95_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic binding protein-like II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1468879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA95"/>
    <dbReference type="STRING" id="983965.A0A2T4CA95"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="88"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="296" mass="32000" checksum="86485FA10DF49C32" modified="2018-07-18" version="1">MATPLRIGFVPEHFSTPLHFAQKHFGLDATLVPFPSGTGHMITALRADEIDVGIGLTEAWIAGLGKEGVEGDGGYRLVGTYVETPLCWAISTGAKRPEITSVDSLKGGKIGVSRIGSGSYVMGYVLADQKGWLTTPGAEPYADTVVLNTFENLRNAVNSGAADFFMWEHFTSKKFYDAGEIRRVGEIYTPWSSWKIVASTKLASSAGGVDARVKDLFEKLDKGVAHFNANPEEAVQYISTNLDYSAEDAREWLKTVRFPARTEGVMPEVVSGCVSILRKAGVLAEGKGMNANEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAF3</accession>
    <name>A0A2T4CAF3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1454410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAF3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="41843" checksum="E1CF6363D1096C92" modified="2018-07-18" version="1" fragment="single">SRPRSLALNSELRWTTPGPRQSRWIHEETDKETGEERHGRTRSCDADMYYLLRQPGTGDPLLGLESRPWSLPDEEHAQRANASERSRLEQHPQDAQSDQTSKRGRSPIPQTLEGGWTPGSSWPSSTGWREAMIWLLAIHHTSWLTAGTCGQVWDARGNAVTSGAEMHDISRGGWHQLQAAYASTEYKEKEDDRVGYTALFYRAWTLHVHSGRSLTRLIRYLARISFDERGLRWEVSWKEGNTRKWVVSPMAGALFGRPFCPCSLLDFSVLRMGDQPVLAVHWQRLSSFAFTNDSMERRVVLVKYWPGGQAVVPSAKALPHPPWSAIVLVQKTRAGIYGFGSALRRISQRKNHVPPMNGRLSAKHDGISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB29</accession>
    <name>A0A2T4CB29_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1461808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB29"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="239" mass="26084" checksum="458E481DF0020084" modified="2018-07-18" version="1">MDLLSTIRKTGSRGGVNFSWDEVANSSHRENYLGHSLKAPVGRWAKGRDLNWYAKSDATPADSAETDEERKAREHKEELRRIKEAEEDAMARALGLPPPVRTSSGANAVDVEPKRQVGPASGPPRDAGRDESRSERSRRHGDDRRERRRHRDRSKSRSRSGAVVIGRKDEMTATGSIDTVEIAIGVEAEIGETTGGVMEKAIGTTKGDTEIGAGSDIARGRESTADEALGQARAEMIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBI2</accession>
    <name>A0A2T4CBI2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1469185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBI2"/>
    <dbReference type="STRING" id="983965.A0A2T4CBI2"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="33"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="297" mass="33061" checksum="D2D1822BD7BD03D4" modified="2018-07-18" version="1">MSEHRRNISFQTTDGVTLKGWFFPASSGRNPCVILTHGISALKEHFIDQTALELRRQGFNALLYDNRGFGESGGRRFDVDPIRAQDDYVDAFDYAASLPEVDPERIVFWGVSLSGGVAISAAAIDRRVKAVVAVVPFVSGELLMCTGHSILDMAQRDRAKILKGEDWPLTGVIASTLEEAEAGTAPVILRDAVSYRFFQRAAAQGGHWENKITTMSLFRLLRFEPIRYVHRVAPTPLLMIVGEKDETLLSPQLQAFGLAREPKYLHILKGGDHFNHYQGEIGAESLGVQVEFLKRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBI6</accession>
    <name>A0A2T4CBI6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1373971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBI6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBI6"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015371760" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="172"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="7">
        <location>
            <begin position="423"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="498" mass="53926" checksum="7EFBC094F3755C90" modified="2018-07-18" version="1">MVSSFASAKALPVLAASAFAAASYPPIPSDLTTPVQQRIAVNGPSSVSIGWNTYQRLSQPCVDYGTSATSLTQQACSQSSVTYQTSRTWSNVVTLSGLSSATTYYYKIVSTNSSVDHFLSPRLAGDRTPFSINAIIDLGVVGPDGYTIQNDQTKRDTIPTIDPSLNHTTIQRLAETVNDYEFVIHPGDLAYADDWIETPKNIFDGTNAYQAILEQFYAQLAPISGRKPYMASPGNHEAACQEIPHTTGLCDAGQRNFSDFINRFGRTMPTVFSSTSANNTAKINANKAQQLAKPPFWFSFEYGMAHVVMIDTETDFADAPDGPDGSEGLNGGPFGAPNQQLQFLEADLASVDRAVTPWLIVAGHRPWYTTGGTGCTPCQAAFEGLFYKYGVDLGVFGHVHNSQRFFPVYNGTADAAGMTNPKAPMYIVAGGAGNIEGLSDVGSEPSYTAFAYADDFSYATIRFLDEQKLQVDFYQSSTGNLLDSSTLFKSHDQQFVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCG2</accession>
    <name>A0A2T4CCG2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4897004at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="268" mass="29637" checksum="9FB4CF97353ED1AE" modified="2018-07-18" version="1">MSERDSSSEASDQETTTMAETNGKMVVEKLLMASRSLKSVLIEVGGMCCSGFEIGWVTSVAVHLYHGHTLIGEMTISNKAMVPDSQNRVAFVWNPDEEPECEYGGIQVSLRRPQKGSNHTLDDRKRVTADLSVSPTGHDLKMSIDLANMPRMRAVVQSVMIFEGEIQVSVDITNLSPLRVIFDGICYFKLLKDQRVIGHLMGGFDIDRGITEYEFKGTVNDGASGMAVLKGDRFSASHHSTWQEYLIQLFEVEVNLGEDPGLEEEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCK5</accession>
    <name>A0A2T4CCK5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1165936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCK5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="14952" checksum="A5FFB0EB826A7144" modified="2018-07-18" version="1">MAESRSSADAVGKAEIMNRLLLTGDAGFGPGAQIGLGSAGGRGFAATRERIEVGLDDLANLRLGDPDGGGQFQVGARGYDCKVQRRERGERRWRSHCCPQITTWPDLRNICQACVHANDGDGRPKLVHEEPKIRPIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCZ0</accession>
    <name>A0A2T4CCZ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1398696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCZ0"/>
    <dbReference type="STRING" id="983965.A0A2T4CCZ0"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="607" mass="67146" checksum="5003EDF3A91DD569" modified="2018-07-18" version="1">MANHHPSPTMMQMQHQAPPPVAPPQNVQPNHFSPSHQIAAMNEAVWLQIGSFSELLRMPEEAMHAYERALQANPNSTAAMSAIGMLLKGREAFDKALEFFRAIVQLDQNNGEAWGNLGHCYLMTENLQKAYDAYQQALVNLRDPKDPMLWYGIGILYDRYGSYDYAEEAFSQVMAIQPDFEKANEIYFRLGIIYKQQSKFAQSLECFKYIVNSPPGPLTQEDIWFQIGHVHEQQKDFDGAKSAYQRVLDQSPNHAKVLQQLGWLYHQQSPAYDSQERGIQYLEKSVAADNQDAQSWYLLGRCYMSQQKYPKAYEAYQQAVYRDGKNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWYDLGTLYESCNNQIADALDAYQRAAELDPGNPHIKARLQLLRSGGTNGGPPPAAPQPADMHPSTYQTGPTGPPQWGGSAQQQSTGPPAATQAAGESWAGRLSNVNPPPQPPNPYESRGGEPFRGGGPAPPLRRVSSNHLPPMQQGAGPMTGVVHEKPNPPVVPKEEPRAEQASTARPAPPPASEPERAARKMDVDEDYDDSGEDEKKAVLTNGSGPSAASSDLKAPNSSVNVNVASGPAPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD25</accession>
    <name>A0A2T4CD25_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1169951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD25"/>
    <dbReference type="STRING" id="983965.A0A2T4CD25"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015706454" description="PLC-like phosphodiesterase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="40783" checksum="BDE92BAA1877A6EB" modified="2018-07-18" version="1">MRFSLSGLLAGCLVGIAGVSAIPQQASPAAAASSTSVSSPASTSSSSSSSNSSSQVCNNSPVLCDRHYSDITHMGAHDSAFLRDASTGNSIAGNQFLNATLALDAGLRLLQAQVHHENGTLRLCHTSCGLLDAGPLESWLARINDWVVGHPSDVVTILLVNSDNADVSQFAAAYQQSGLSKFGYVPPSTSDDDDAAIAEWPSLRAMIANNTRVVSFVTNIKASTASPYLLPEFDYVFETPFTVLSLDGFNCTVDRPSDAGTANAAFAKGFMGLVNHFKDEEITAGINIPDTENIALVNSPGTSDAGNLGQHIQQCNDQWNHRPTFVLVDFWDKGSTVKAADDSNGISQASGRKNASADGASDSAAEGTNQTREFGTGALIAFLAATLLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE78</accession>
    <name>A0A2T4CE78_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin filament-coating protein tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1389747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE78"/>
    <dbReference type="STRING" id="983965.A0A2T4CE78"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000114">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17905" checksum="315F4E50C5063C89" modified="2018-07-18" version="1">MNSLRLEADEAIAKVEELQAKVKSLEQENLAKEQEITSLQHKNGLLEGEVEKLETAIKDFKKVADEGQEHGTQNETLQRRLQLLEEEAEEADKTLREANEKLRQTDVKAGHFERKVQALENERDQWEQKYEEMAKKHADLQKELEELQNEIGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEJ5</accession>
    <name>A0A2T4CEJ5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEJ5"/>
    <dbReference type="STRING" id="983965.A0A2T4CEJ5"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="316"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="533" mass="56693" checksum="F91C5D65354898EA" modified="2018-07-18" version="1">MFRPVQNTGPSTATPGTSSSRSTHPSVAEAASRSRNDAFASHTSAAPTFQRPRRFLLLAREKLEPAVPPPLPAARVTSRSRIVDSMEPDFTPTESAIRDGQQNVPQSRGNSNPGPSNHPVASAAASSSRIVQQPIPPSRRASVVGQVDSTATASFSSRITQRPIPRTERNTGPADLEPRIISSSSANRGSRPFPLPQLRNAGSVTTTSKNTPAAHAAYQAIPRPARHNEPTRTPVTSTSRAAQQSMHQPTRDALPTHTSTSSATRITQQPTVHPPRTSTHALSASASRATQQSTFRSANSTAAPMDTPTSSASASILEFICLYTHDLRRKKKRWQDGKLKFHTFNKKYMVYDDGGGFVGDGHWQGDATEVAEGLEMNLDRGMAIVQLLECTGSKEQDLGEVLGKRAREVEERRVSAAAKLSSSAAPSNPAKRSRGGDMMVEILPPTTLAIGIPLAPRNGGGAGVAVAVETPTPTTLAPILPPPPRKRAAGVAMAVVQTRPTTGSTMAPLPPRNGGAWSTHAMDLMGITRPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEQ3</accession>
    <name>A0A2T4CEQ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1368857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEQ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CEQ3"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="661" mass="74542" checksum="F44B20BF1F18D5AC" modified="2018-07-18" version="1">MPSRMIIDSHGDDEVQYLTSRDVAPECRSRSSSSATLGRTADDEDDDEEEAEELVELFEHEVIDLTRHESEDGSHDSIRPGELALDKFREPRSGTQLFRGDLIQVEHVELGSYTIDFVQIKVIARDRQGDCKIRGIPFVRTRKLLGKLPKKTNEICMILHIQRRYDGQELPAVLIDVPTASIVKKRELVMTNAIYPEHCYNGENIGLHIQNEQAPQRLAEDHGKLTCRWKFAIYFTMQRQSRATRPEEELLERVQADEVPVSRYRVSDEGLCNHWRGGRIKGGSWPHTESSIVDLESKPSSVNTAHRTGSRRLGQKYTLFDSFCGAGGVSHGAQSSGFKVQGSVDEFIRDSKDRRMRVDVLHLSPPCQYFSPAHTHQSVHDDTNIFALFGCLSLIYKLRPRLITLEQTFGITHERHHHYLRALIGDYTQLGYSVRWKVVRLCTWGSAQDRKRLIILAAAPGERLPPFPKPTHSETGAGGLQPWTTVEKAIGSIRVGDDLHNLDSVKYHRPPRAPLDPRRLAGTITTGGNEVYYPDGSRDLTIREYACIQGFPKYHKFFGTKTCIRRQIGNAFPPNTVRVLYRHLEDWLLQQDGMTRGQPLADSVLSVDDSDIDPSDDYAGSQTYSMAPSAPEMGEDVVELAPPCGRPRGTGHRCSALVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEX0</accession>
    <name>A0A2T4CEX0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1112175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEX0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="159" mass="17326" checksum="4A64D4491223BBF7" modified="2018-07-18" version="1">MSTLPFFIRQPLVLVFRNLLQVASVHFLIQSPRLASPCPSPLVPHFEPEAGRQNAPPMAAKPCLVVPLWPCLVSVNRVRQLLFFPPRPLLLINGWQVSRFFSLSDAASAIDPGSATGSIRPEKRGNPCPPLGGRTSLSDARPALHSHDLHAARMLSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFU2</accession>
    <name>A0A2T4CFU2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1436028</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CFU2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="978"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="272"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="613"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="977"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1200"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB80416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1441" mass="157062" checksum="76A755EF37CBC12B" modified="2018-07-18" version="1">MNKSTPLCAATADAAFGPVVDAACRDGFDFTLVFEQFVFVLLPASLLVLVAPLRLMQLRKASVKVTDNVSRALKLSVTACLAALQLVLIALWATHNGPARLSGVSVAAASVSFASSLMSCALSYYEHARSLGPSSLLNVFLLVSLLLDAAVLRTVWLALSEEAVSTAIQAVLTASFGLKMALLVLEAREKSARVVGRRTLAPEETSGLYNRAVFAWVAPLLRTGFERLLQPADLFPLDEKMGASGLNERFWWHWRKGFTLRSAVSAVIVPRLALLAFTICQPLVLTRFLGFLNDESQPVNIGYALVGAYGLVYLGIAATQALYWHQNGRCVTMLRGVLVSAVFARVTDVSVVAADDSAALTLMSSDVDVIGRAMREIHEFWANVLQIGIATWLLSKQIGYAAAGPIIVSVLSLVATMFVSPLAGKYRVGWLEKTQKRVGITSAMIGHIKSIKMSGLSKHLSTTIATLRAQEITASKPFRVVGAVTSSVAQIPLLLSPVLAFVMFQGITAATGQVLDATRMFAAFSLITLLAQPLFWVLEVLLDLSAAFGAFGRIQAFLVKATREEYRTLRGANGLGPSATREEDAGLIELQTLRPLASRSASHNLANTYTIAIDVEDATFAWSPERQILSNISFSLSRGQFALLIGPVASGKTTLLKGLLGEVPHSSGRVFLASSRLSWCEQSPWILNQSIRDNIIGYSHFNQDLYDQTVKACELEEDFRQLPQGDFTVVGSKGLALSGGQKQRVALARAVYSRPCIALFDDIFSGLDNDTSRRIFNNLFSSTGLFRKWETTFILATQTIEFLASADLIIALGRDGKITEQGNLAQLQATGGYVQTLIASKHTVGDPDAGRDGILLESGDGHTTPKVEYKAKQVESKEDKRRQLGDSTVYKYYFGSIGKFLIITLVALELVWAFLQSFPTVWLKFWTDSNGQRGESSSYYLGVYAALQIIGVFWFALLIWFVLVVIAAKSGISLHERLLSAVANIGILDNNLPLALVVSIASFFGVLARAGLLAASSYYVAISFPFLAALYYLLQRGYLRTSRQLRLLDLEEKAPVYTQFLETLAGISTIRAFGWQKQAVLKNHELVDRSQKPFYLLIMVQRWLVLVLDLTTTALALLIVGFSVKLRGSVPVGLTGVSLVQLISLSETLNMLIQFWTSIETSIGAVARIKQFAEETPDESRPAEDREVPAHWLNRGHIVIRDLEASYDESGGIKALDGVTLDLKPGEKVGICGRTGSGKSSLLLALLRLLDPSSGTLTIDAIPLNTIARETLRSRLITVTQDQFVLPGTVRQNIDPSASYAEEAIIDALHAVNLWATIDARGGLDAAFEEDMLSHGQKQLFFLARAVLKKDCGKVVLLDEASSSLDKETEQMVRTIINTHFKAHTVVSIAHHLETILDFDRVVVMDKGRVVEVGSPRELLQSAGNGKFKALWEANGRGRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGL2</accession>
    <name>A0A2T4CGL2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1370082</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CGL2"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1968"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2623"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2965"/>
            <end position="3131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1209"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1668"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3213"/>
            <end position="3304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3453"/>
            <end position="3494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB80684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="4217" mass="477013" checksum="03B4E427F946BCD7" modified="2018-07-18" version="1">[encoded data, 4217 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH00</accession>
    <name>A0A2T4CH00_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1322686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH00"/>
    <dbReference type="STRING" id="983965.A0A2T4CH00"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="15"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="15348" checksum="1A899FDE310D9536" modified="2018-07-18" version="1">MDASHHFGADVASAVFENLQEQHQWASLQFHRLPGLSRPMIRGLPPRLLYLHPDDQIAALAYEKSTGTRAQHDAEFEWVLAVHLAEKWTLSGLAAVMDALPEARKRAKRIVLAALHNDSTVVYYIVQEGMIKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH25</accession>
    <name>A0A2T4CH25_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1417628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH25"/>
    <dbReference type="STRING" id="983965.A0A2T4CH25"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="83"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB80844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="496" mass="55958" checksum="F67CC10517C27171" modified="2018-07-18" version="1">MDTYRYRVPKPNYLPHKLDVDLDRDIVEEYTQPLGIASDADNAKFYQQCKRLAESSGITRPKGYNVSFHCNPEMEKHHFGMTHPMKPWRLTLSKSLIYSYGMSFAMDNYLTRAATYEELASFHSTDYLDFLGTVLPEAVPRDLENQNPDLKFNLGGSDCPLFDGLYDYCSMSAGSALDAARKIVSQQSDIAIAWGGGLHHAKKAEASGFCYINDIVIAILELLRFYPRVLYIDIDVHHGDGVEEAFFSTDRVMTVSFHKYDPNNFFPGTGALDDNGPKSEHNPGAHHAVNVPLQDGITDEQYDSLFNNIVGRIVEKFRPGAIALQCGADSLAGDRLGRFNLQVQGHGACVEFCKRMNIPMILFGGGGYTPRNVARAWTYETSIAINCQDKISPILPEHAPWREHFRQDTLFPTIEQILGEARANKNTAKKMQDIVNHVTEQLRFVQSAPSVQMQVIPPDLGSFRDEVEERLKEEQEEKNEQLRRERESGVGTAMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHR9</accession>
    <name>A0A2T4CHR9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1434967</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHR9"/>
    <dbReference type="STRING" id="983965.A0A2T4CHR9"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015753849" description="Mitochondrial import inner membrane translocase subunit TIM14" evidence="14">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="15">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB81084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="10913" checksum="4D0B91F1D1BC0AB7" modified="2018-07-18" version="1">MAWGAGVAVAAFLGRAGLVALRRSRGGVGAMGKAFYKGGFEPRMTKKEASLILSLNERSITKDKVRKAHRTLMLLNHPDRGGSPYLATKVNEAKELLDKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI68</accession>
    <name>A0A2T4CI68_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_44434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI68"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="218" mass="24460" checksum="11B22F533A8C086C" modified="2018-07-18" version="1">MKTRIITHMNSQHTRELSHYLRHYAGLSARAAAASPAIQDMDLTKMTISTRGGGGGTYDVPFSPPLSSWAEARPRVIAMDAAAREALGISDVYLTEYAFPRGFDWVPLLGVCFYYVCAAGLPWVVPGSAAWDVLGRVFPGGPEGFRWVIKTIFGIVLAIHLVEVYLLDKWRLQKHGVARFSGLWWAWASNIFVEGVTTWKRLDRIIAEKRAQKEEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI81</accession>
    <name>A0A2T4CI81_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1011383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI81"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="253" mass="27656" checksum="F688DAE58B533EFD" modified="2018-07-18" version="1">MVITSPEPILSSLPLQIDNQPASKPHTRWQPGIRVSCRFAGRVCVLPPTRPDSTSQVDTRPMPLVLRMHSRHVPSVRYSLVRRCHITSRQPLSHPAHAHAGPTGWLAAGKDAGDVKAPSAEASAGHSFPLSYLLDAAKVQFKSRYHSLITSFLSTSRHSFFFPSFSSKNRIGCYVCVAPPLAGRLVSPPPRASALEPTSDLCTLSLSLLSFFASYSESLPCMESRYFWSLENLLISSREPADSSFFTASTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIC7</accession>
    <name>A0A2T4CIC7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_35812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIC7"/>
    <dbReference type="STRING" id="983965.A0A2T4CIC7"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="454" mass="47221" checksum="58D85A73550220B6" modified="2018-07-18" version="1" fragment="single">AEQVLGVYIFHRHGDRTSKAWPPVNLTPLGAQQVASSAAFYRARYISSSSSSNTTTIEGISPDAAVLSQLSITAPVDNVLQNSAAVFAQALYPPSKAAGSQKLANGTTIEAPLGGYQYIPVNAVASSASSAGSESSAWLQGSSGCGDAVVSSNSYFLTPEYLDTLNRTHDFYQGLLPVINTTFNSSTATFKNGYSIFDYINVATIHNSSIPSSSLLTNSTLSTLYDLASTHEWNLAYNASEPARAIAGSVLAGQILTALQSIAESSKPSSPRINVQFGAYGAFMAFFGLAQLPAASNDFYGICDYASSMALELVAPSPDKTSPDDLSVRFLWSNGTAGEHGLKEYPLFGQKQTTLSWNDFKAGISKFAVASTQDWCTVCGNTDGTCAANATDSSSPSAQSDDHHEGGSGISRPVAGVIGALVTLGVILGLEALVLLLGGLRLVKKSTLAGAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIE4</accession>
    <name>A0A2T4CIE4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1396486</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIE4"/>
    <dbReference type="STRING" id="983965.A0A2T4CIE4"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000006">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="249"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB81335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="453" mass="50462" checksum="659C9138FF8B2819" modified="2018-07-18" version="1">MRGEILHLHVGQAGVQLGNAAWELYCLEHGIGRDGRLNPDAQDQDDLGSPDTFFTETSNGKHVPRSIFVDLDPSPIDEIRAGDYRQLFHPELLISGKEDAANNYARGHYTVGKEMIDTVMDKIRRVTDNCHSLQGFLIFHSFGGGTGSGFGALMLERLATEYGKKTKLEFSVYPAPRTSSAVVEPYNAVLSTHSTIEHSDCTFLVDNEAVYDICQRNLDISRPSFDHLNRLISQVVSSITSSLRFDGALNVDLNEFQTNLVPFPRIHYPLISYAPVVSAKKSSHESFKIQDLTYQCFEPNNQMVVCDPRNGKYMAVVLLYRGDVVPRDCTVAVAHIKAKATFNMVDWCPTGFKLGITYQKPMAVPVAAEEGGLAAVKRSVSMLSNTTAIAEAWSRLDHKFDLMHNKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSFGPDDTAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ04</accession>
    <name>A0A2T4CJ04_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall proline rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1018055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ04"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ04"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="103452" checksum="4694F9F492F31603" modified="2018-07-18" version="1">MMATALYTPERAAVAPPVHNMEGAVDYLASLDDATTASLARGPASQHGALPPPNPQFSFPAAPPTPSHDSIAKRRRPMSAVEMHRPLSIAVDGSRHAALPAFSFNPGASLPPDPRAFLSPPHSPNSAKQTPGSASTNRPMGHGHRRGGSEFVGGRLREGSTIAVMSTSPPKNEFDLKTPNLQPPRRGHRRGMSATIPATDLPMLFAPPAIGSLPQGNSAPSSPTIVGRKEDLPLIGFEFPLPEPTEPGKDNKSAGSSKAPLLAPDEAWKMGKPMLRSKVGFSDTLEFIPRPLSLVSNDTSSTITARPGHSVSGSVSSVISVTSNNGRDGSAPLSRTASEPQESRPSTAGAILERTAELQITEEPPTSPRRRNSIPALLNISDADATESNVSTPSKPAKRWSFFGLDAFASGSPVKRRPSSSGSSECAPRPVDRISCSDRASESSLDTSETPSSKHKKGSQKGDKKKKKSKKEKKEEKKEKERKKEEEKKAKGWAGSILPLKGHKKRGKSSAVRPPTPPASVSHPDDDEEDETERDIREPSFEPPTISITESPPLPEPSEPPKRHSEEISSPIIDLDAALGPFNTPLSYNPEWEAAQRAAGTPSSRRRLHSAQGLKGFSGPGMHYHRRAESAPDLPPFDFRSSMHRFGSSSTMADVFEEDEEDDDGKGHPRTRLETSEETSEESDGETTPPAVVPVSKEAFGAPSDRALGKMRRRSAGIMERESLSSQAARADAFKISLQDETIAEEFSLPIFRAPTFQGRRDSVDSGAPSAPSPRQLPVTIDMPVDEQPLALPSAGISPLSPYSASYASSPHPSPRTPMSIDAQRISTAPSSVTDDSFHSLLMGEPGPEVRISMDYDVPSIASSTSAMTRDSTYIPAPRPRQPLARDQRPVSMSAPFGRRRSSLASLSRLISSSHGERSKLSMEVTLDNEPESKKSKSKTKRLGRMMQFWKPNKDEKDKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ54</accession>
    <name>A0A2T4CJ54_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1435330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ54"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ54"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="4">
        <location>
            <begin position="221"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="35228" checksum="B2E4760538C68533" modified="2018-07-18" version="1">MASTSTATPTKVGILSLGDMGAGIARLLIAHGFPVSTNCQGRSEDTVERARDAGVELLSSDSELVQQSSVIFSVVPPRDAEATAQRIVDALSGGSRTQTLYYVDLNAVAPSTCKSIAALFEKARVSVKFIDACILGGPPSLKKKKNDSDKDGEVNEEWDQPSIPVSGSDLLTALPDGERLASVLKLRTISPEIGAASGLKMCFASLTKGFTALATQSFATAHRLGVADELRRELRDMAPAMLARAEKGVPGMPPKAYRWVREMEEIAKTFAEEGGWEGTVFEGIAGVYRAVAEDDVLGREKIGKRKRGTSLDDVAAVMAEGLEAKRKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ92</accession>
    <name>A0A2T4CJ92_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1396787</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ92"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ92"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="11">
        <location>
            <begin position="112"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="12">
        <location>
            <begin position="229"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="313" mass="34260" checksum="94323C3D4E3D1B51" modified="2018-07-18" version="1">MSRQINLPSNQIKLTNVSLVRLKKGKKRFEIACYKNKVLEWRSGIETDLDNVLQIPNVFLNVSKGQTAPKEDLEKAFGKGKSTDDIVLEILKKGELQVGDKERAAQLERVHNEVISIVVSKLVDPRTKRVYTPGMIEKALDMLSSQAHNNNTDKEKSTDSGSATPTTGEAGEAKPKTKEHTWTGVTTTKSAKSQALDAMKALIAHQPIPVARARMKLRVTCPTNVLKQAIKAPKAAAKEEEDGSGEAKAPGTVKDRILGYFEEVESQDVMGSEWEVVGFVEPGALKALSDFIGNDTKGQGRVEVLDMAVTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ99</accession>
    <name>A0A2T4CJ99_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ99"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ99"/>
    <dbReference type="OrthoDB" id="610462at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29427" checksum="0467EF81C8554354" modified="2018-07-18" version="1">MSNRHVFPTSLIDVQPGNETGDYHITFCNLALNTTWQEMKDWFSASCDVDFIEVFPSNCSGWMRVKGRDNFERALEHLRNELFRDQVLHFDSRNETQAIKIRYKENSPRPKHARRKRSNRGNPGQKQPCGYPVPQNCHAQSPLPDEYAWLIQSDHVHAAEAAKRRAYEEYLAFASFVYNTRLHNTLSMQYPVSAFPYCQPEHYGGLSLDSYGNYCSPYLFGGSPAVYTTQVGCSGSVVSTGSSDMPDAPENWLGYGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJU9</accession>
    <name>A0A2T4CJU9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1396997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJU9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJU9"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="131" mass="14973" checksum="655A3949DF482AB9" modified="2018-07-18" version="1">MVAAKKHVPIVKKHKTRFARHQSDRFDRVGESWRKPKGIDGRVRRRFRGTIRMPKIGYGSNKKTRFLTPSGHKAFLVHNVKDLELLLMHNRTHAAEIASAVSSRKRIDIITRAKQIGVKVTNAKAKVTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK14</accession>
    <name>A0A2T4CK14_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK14"/>
    <dbReference type="OrthoDB" id="4181370at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503:SF2">
        <property type="entry name" value="BLR2408 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503">
        <property type="entry name" value="BLR2520 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44913" checksum="04C08C8C953CC699" modified="2018-07-18" version="1">MAPTKDSESPKKSKPPKDSQPPKETKPLKEAEPRKEDKPLKDPKSPTDTKSPKESQPHKDSKPPKEPKATKDSKPLKEPKPLKESEYPKESKSPKEPKSAQDSKPPKPPKDSESSKEPKLPKEPKTPKESKPPKESKPPKEIKSPKESEPPKEYKPPKESKLSKGPKSLKESQPPKDSKPLKESEFAKDFESPKDFESPKESKSSKESTSSKESKSSKESKESKSPKESKSPKESKSPKESKAPKESKSPMESKPPKDSKPPSFFVSLPVESLESAGDFYKSLNFTPLPAFSDYSTAAFRFPYSANSNICLMLHAPSRFQQFVREGSEIAEPKKATGAIFTLGVGSRETVDGLLDKAQKAGGKKDPFKMKEYGKSLGIYTRSFEDVDGHVWEATTMLDEKGKDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK66</accession>
    <name>A0A2T4CK66_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Killer toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1322324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK66"/>
    <dbReference type="OrthoDB" id="4177994at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.10">
        <property type="entry name" value="Killer Toxin P4, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015131">
        <property type="entry name" value="Killer_tox_Kp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011329">
        <property type="entry name" value="Killer_tox_Kp4/SMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09044">
        <property type="entry name" value="Kp4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55221">
        <property type="entry name" value="Yeast killer toxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015418247" evidence="1">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Killer toxin Kp4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Killer toxin Kp4" evidence="2">
        <location>
            <begin position="149"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="264" mass="27788" checksum="78094190F0051BCC" modified="2018-07-18" version="1">MFFAKTLFAAAGIASTVNALGINCQGSGLCTGNKGLLGTVLGQVKAMDQSKIFSDGEHIACAQSSVTIADPSLCLFYQKTGRTFTVAQTIWYVQALMDHGCTACGSIPVDDGNNVDNGELTANMVSFAKRRDTGMVKVVRKAEDKAENVSKLSKRLGINCRGSSTCGVGGVANLPAGHIDDLKNAIAGQGDGVWGNGQQIGCVPHVTGRICAFYQNVGDRTFTTQQTLMYLDWLMDHGCTVCGSVPTDDGNNVDNGELTVNYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CKC2</accession>
    <name>A0A2T4CKC2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1321262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CKC2"/>
    <dbReference type="STRING" id="983965.A0A2T4CKC2"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015786408" evidence="2">
        <location>
            <begin position="25"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="627" mass="66966" checksum="8D2CA0BA6C2B44AD" modified="2018-07-18" version="1">MLGLVSRLGLGALVASALASLAAAAPANVAVRSLEERASSADRLVFCHFMIGICGDRTSSTDYDDDMQRAKAAGIDAFALNIGVDGYTDQQLNFAYDAADRAGMKVFISFDFNWWSPGNAVGVGQKIAQYASRPAQLYVDNRPFASSFAGDGLDVNALRNAAGSNVYFVPNFHPGQSSPSTIDGALNWMAWDNDGNNKAPKPGHNVTVADGDNSYRSWLAGKPYLAPVSPWFFTHFGPEVSFSKNWVFPGGSLWYDRWQDVLRQGFPMVEIITWNDYGESHYSGPLKSRHYDDGNSKWTNDMPHDGFLDLAKPFIAAYKNRDTDVAAYIQNEQLIYWYRRTLKGLDCDATDTTANRPANNDSGNYFMGRPDGWQTMDDTVYVVALLKSAGTVTVTSGGATQTFQGNAGANLFEVPANLGQQKFALSRSGQTVFSSTSLMDITNVCPCGLYNFNPYVGTVPPGFDDPLGPDGLASLTIGLHVTTCQAKPSLGTNPPITSGPGSSVPVSTTRSTSPPGSTTRFSSTSVSSRSSSSTPPVSTPPPGQVCVAGTVADGQSGNYIGLCNFSCNFGYCPPGPCKCTAYGAPINPPATNGRNGCPLPGEDDSYLGLCSFSCNHNYCPPTACQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPA8</accession>
    <name>A0A2T4BPA8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1387359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPA8"/>
    <dbReference type="STRING" id="983965.A0A2T4BPA8"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="13571" checksum="FC8D60ED732C5CF9" modified="2018-07-18" version="1">MAIPNEALQKLALEIESQAIAAQQQIGIVRTQLAAKQREQRLLRLTMSEVQSFPSESVMYEGVGKMFVSIPPSTLQEKLQRQIQDLDGDVDRLNQRLLYLETTHKNSREHIDQILRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR47</accession>
    <name>A0A2T4BR47_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_350325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR47"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="16841" checksum="930DE2D5F0F3843F" modified="2018-07-18" version="1">MDVHTLNRHGQNVKFCSTAPGFRHGQDESRPFMTVKISSHLAQFVWSIAWPPSTSSMCMFARNVSVLLGFGANIVMPALLDGITASDMRNSQPAAISQAYVRFREEIAHIDESMPRTITSTSDSENVKARRGDKVRASVWNGVRYIRVLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR81</accession>
    <name>A0A2T4BR81_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1364759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR81"/>
    <dbReference type="STRING" id="983965.A0A2T4BR81"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="150"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="299" mass="33098" checksum="9A9140DADD6D9F6D" modified="2018-07-18" version="1">MDFAGDGRNDALADGRRIYLGNLHYELRSEDIEEFLISNGFDDIENIQISVDAASGRNPGYCFVDFSQKATADRALNELTASLRGRELKVGPCEPRKKRTGDGRQGFQRSNDWRTQSGDDSQQFQGGEAREQRPRGFTRSDEVADESQGKRLYVGGLAKMGDPDQNTQEVMDIFTGFNPSHIGKRIAPPESSRSPAGTYYYCFVDFETKEEAEAAMQALDGAQYDGGLLKVSLAKRTDRQSNRPNTTSDRNGGQGRGWRSNNNSNSNSNSNSNSNTRPEGGPPAARAMGSNNWRRREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS43</accession>
    <name>A0A2T4BS43_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_366665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS43"/>
    <dbReference type="STRING" id="983965.A0A2T4BS43"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="14"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="402" mass="43021" checksum="043D748619CE4389" modified="2018-07-18" version="1">MAPTNKQWVSKLDGVDKLELVEGEMPVPQDGEVLVKIHAVGINYRDIEVCEGKYSHHQTPSDSPSGVVICSDMCGTVLESKSPLLAAGARVMSVYLQTHLAGALRQSDLESGLGFPLPGVLAEFRCFDARALVPVPEYLTDEEASCLPIAGVTAWMALNWMRPVGKAFQTLDLYGQGGKEKRDDDDEEEKKDTETVLLQGTGGVSIAGLQIAKAAGLRTIITSSSDEKLEQAKKLGADHTINYRTYWEWQDQVLEATGGRGADYILEVGGAKTLRKSFASVAFGGTISCIGYVSGKEDDTGGEDGGGGGGGGGGGDEGGDKGEAAGWNRLNVNVLALRRNVTLKGLINGGKDRFEEMVRFYEKKGIRPVVCKVFGMGEGREALEYVKGGKHFGKVVVRVDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSB4</accession>
    <name>A0A2T4BSB4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1405582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSB4"/>
    <dbReference type="STRING" id="983965.A0A2T4BSB4"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="89"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="364"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="578" mass="64375" checksum="406CB1C427650D26" modified="2018-07-18" version="1">MPPSSSKEKRLAKKAEKAAASGKKIVGKAGKKEPELDVHGNPIQDTDGPATTDDKLDEVKRLADQMDQHGISDRVTTGVLSSTQQSKDVKITSCSLVFHGRVLITDSTLELSFGRRYGLLGENGCGKSTLLKAIAAREYPIPDHVDIYLLNEGAPPSELGALEWVVKEAENEMERLDKLAEKLLEDEGPESPVLIDLYDHMDKMDPSTFATRASLILTGLGFNKKTIHKKTKDMSGGWRMRVALAKALFVKPSLLLLDDPTAHLDLEACVWLEEYLKKWDRTLVLVSHSMDFLNGVCTNMIDMREKALIYYGGNYDSYAKTREENETNQMKAYTKQQEEIAHIKKFIASAGTYANLVRQAKSRQKILDKMEADGFIQPVVPDRVFTFRFADVDKLPPPSTLLRLMTGKLSPTGGSVSRHTHLKLGLYSQHSAEQLDLTKSALDFVRDKYKEKSQDYQYWRQQLGRYGLTGESQTALMGTLSEGQKSRIVFALLAIDSPNMLLLDEPTNGLDIPTIDSLADAINAFSGGVIVVSHDFRLLDKIAKQILVCENQTIRAWDGTIGDYKNYLRKKMITAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSC4</accession>
    <name>A0A2T4BSC4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1433815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSC4"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="16884" checksum="BE2A21B47011CC29" modified="2018-07-18" version="1">MCGPETTNRPRGGALAALCSLDDAGHATTCGDLAFHTPGLPESNEATHVRLMPDAAYDARTLSDLLVVIHSSGDPRTRIEDCGTFKKFGFPTTAESFSKTQAFVELPLSKPLLLEVGNEGIIGRRVSLYAGASPGRVVAEGIVGVNFLRTAQPSLGMVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT08</accession>
    <name>A0A2T4BT08_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_347878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT08"/>
    <dbReference type="STRING" id="983965.A0A2T4BT08"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015373319" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="558" mass="62096" checksum="7ACFC774A1258635" modified="2018-07-18" version="1">MKFYWTLPILTAASGITAQQSWPGASQRLIKAFKNRPEARRSQQPKERASTVAPLPPTRFLTDATKKCAVNGSTIPDVPLDVGESYAGLLPISNNTEEKSSLFYWFFPTANPEHQTKEEITIWLNGGPGCSSLVGLLKENGPFLWQSGTPGPQPNPWSWHLLTNVIYIEQPVGVGFTKGAPSITNQDELSAQFMGFWRNFVDLFGLHGWKVYIVAESYGGFYGPYIASNFIDANDTDHFNVAGLMVYDGIFFDDNLQMNVPAQSYINRYKELFALDDAVRARVESIANECGFTYYFNQYLMFPPAGPQPYLTPGLEMLPDGTVVVNETCYNLWDYITDEAYIKNPCFNIYSITDHCPTPFNPLGYMPYFNRDDVKKAINAPDSVTWNLCNNDVFNTTDGRDTSPPSGLKQLPDVIDKTQNVILAQGSLDWILVTEGVLLGIQNMTWGGKMGFQSQPQDPFYVPLYGFYPYDIGYWGHNLPSGSGVQGTVHTERGLTLVAMQLAGHEGPQYLGAAAFRQLEKLLGRVQALNSTEPFTLPALRNIPQLQEPLGKGIVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTC6</accession>
    <name>A0A2T4BTC6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">T-snare, syntaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1441878</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTC6"/>
    <dbReference type="STRING" id="983965.A0A2T4BTC6"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="246"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB72545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="344" mass="38539" checksum="747D389AAB62DBE1" modified="2018-07-18" version="1">MWRDRTNLYSYAHHPSHRSKYAAASGFSDAYSSSIGGGGGFALDSDRRGLLSSGAFEDDGDAVIEMDLLPPRWTDVSDEVTELLADIATKSQRLDKLHQAHVLPGFDDDEAKKSEEVQIERLTQDITRGFHQCHQRIQKVEHMVRESKQSGTMTRAEETMAQNIQISLATRVQEASANFRKKQSAYLKKLRGMGGLGAVSPIDRPTSPMPGSSFMDPSLQESDADRSFSQSTLQVAMQQKTLHSNDAAIAQREREIEEIAQGIIELSDLFRDLQTMIIDQGTMLDRIDYNVERMNTEVKAADKELKIASGYQKRSIKRKVILLLLLLVAGLFILLLVKPKKNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTK5</accession>
    <name>A0A2T4BTK5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1441907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTK5"/>
    <dbReference type="STRING" id="983965.A0A2T4BTK5"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="6">
        <location>
            <begin position="102"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="5">
        <location>
            <begin position="332"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="56271" checksum="986FC3521DFCE677" modified="2018-07-18" version="1">MAADGQRDGVLDTLREIQQTQQRLVSSVESLASKLSPPTISTEALDTASKLPATNLAPEGSQDDAKCKDAGELAAIQSSFENATAQPSSALSPSTRTGFTSRIVLTTYPKQIGIDPLPMNWGNPDPLQRGPVVVSRAASTIRRRNGSGGSYSIYYALAVASKELNVDHRPDYTNTEPAAKIGPFPQWGDKKKIVAMDPWGHLVPWTFKDIMEKENVDMRPTIAITKAHMKLPELEESVRSGRLVPDGKVCLNKLGELAVTKFAVEPVWYLPGVAERFGIDEATLRRSLFEHTGGSYPELITRGDIKVFLPPIGGLTVYCFGDPDKMSDESVRLSLRIHDECNGSDVFGSDICTCRPYLIFGIEEAVKEAQNGGSGVVIYFRKEGRALGEVTKVLVYNARKRGEDRASDYFMRTENIAGVKDMRFQALMPDILHWLGIKKIDRMLSMSNMKHDAIVGQGIPIHERVELPEELIPADSRVEIDAKITAGYFTSGKRLTAEELQTVQGRMWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTY2</accession>
    <name>A0A2T4BTY2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1082956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTY2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="117" mass="12993" checksum="6567C2DBBED35CA8" modified="2018-07-18" version="1">MKRVTAFLACVPTHETKLYTGSICAPSSLHMHTSSFFFFVSSSSQNSCHPSKSKMGEKAQVVAVDIPHPLCGCNPSFSPSIQPRFRLRCSDAREGCLVVDLPRLHLPRFRVNKPFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUB8</accession>
    <name>A0A2T4BUB8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1441766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUB8"/>
    <dbReference type="STRING" id="983965.A0A2T4BUB8"/>
    <dbReference type="OrthoDB" id="4898188at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF4">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="649" mass="73088" checksum="1EF48DA76C402A3A" modified="2018-07-18" version="1">MSSHMSSESKAEAFDLGSDKVSLKERIELVWKDMRLNPTAPPPVDHEEDASGHSEENDDADDFATVSVRSDEAEPADIIVDCPLWRDLPECLMDDLLASARDGSNHIELLNKVLGNLLTCKFPSSIADECDMHLVVAAAADTLRRLPGCSTQLYDDTHLYSPYSHQTMSQEGYLIDPTTPEDHGRGSRWASYKVTTLFDTNTIRLALLVAYLDQTTHPLASYTMQGYVNLLSRLLETLSKSYQSFDFETWSHRHAYRVTLAFLWTAWQRSLLLYSHYVFGTRLRQQVNARFIDNLPFPDTPVDADIEFSTLGTSLQGDDAQESLGCDYVCRYSFELLKNSALSGTQDYRRLFARFNELFADKDARCRQTDSGTWAQCDGKSWKTCGRFFGLEVPDQSAHDISCAKPCKRLAWDEASYRGVDGPRSVCLSFTPPGGPLRYRTASDRTLAVSHVWSHGQGGTPDQGFNECLHDRHGLPHVELRSHPQCSSRLRLGSRHTAGPRSLHVLARTQHSSLLALRRLGHERGQDHDARQRQGDDDVSSREVARAQGYARVVFLRPLLVESVESGMTPELSAPFTAAQNRDEGERVAVAVCATREDHAQYVDVAYPEEYTDVYELEPECWEWKGVCWCASADVASRLRFETRQVRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUR8</accession>
    <name>A0A2T4BUR8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1441321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUR8"/>
    <dbReference type="STRING" id="983965.A0A2T4BUR8"/>
    <dbReference type="OrthoDB" id="4847496at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37832" checksum="CF098C526A378F3C" modified="2018-07-18" version="1">MPLGKRSLPMPPMSAGDARTKRLRTATVVQETRHSFAPAHRFDNGEGSSSSFQMAQEQEITEAAVLVAEAATLQATASSSSRAQTNRRRSASCHALRTDSCSLGDMGLEIPAGVAAAEQSRRKDALRIEIEFHRSNPPILPPSKVEDLPPKPFIEDFLRIPEDVTPEERRVMEDENNRIAAQHQLIDRQRNNQAAKKSRQARLESLWNTRELLNAKAAECFWFRMKVISLGGSTEEWDLVPANVKARLVKEIESRVEDKEKQAADEKKTEEAKKRAERNKRRAEVREQTAQQQQQQQQLQLQQQAEQLQLQQQASGYEQLQQQQQLAGEHQPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVG2</accession>
    <name>A0A2T4BVG2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1059612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVG2"/>
    <dbReference type="STRING" id="983965.A0A2T4BVG2"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="460" mass="52064" checksum="A00302013053EEBB" modified="2018-07-18" version="1">MKYGEQLERESVPEWSLHNVDYNSLKHEIKVHTTRDQATALAIPGHQDTSLRRFEDALYNELCHQHDRLDLFVSSKADEVSRRLDHIAASIKRFTAKNHHQSDLPSASLRNQRKFLKYERELLRCREDTQALIRFVNAQVTAFRKILKKYRKWTGSTSLSTRFNDEVLSNPKSFIRRDFTNLQRRHDEVQEMLRNATPAYSEPSSPSSVDTPLAPSTRRDSGSPRVTFDPLPASYLDPQTKYWNEYDDGSEAGNPEDDYAIYIDPDQGSSFPGLKYAQAIVSFPLEKAKEWLGKPRSSERQPLMSSHLSGDSFNRGYGSTTAVHTDSEEDEEAYASSDNFPTQGYAAHYALPSVNNQRLHRYRERVLLWGTAGCFGAAFVFFGIAGILISTGRHKLRVEVDAGATVGAMVSLFCACSGLGMTLYREDRLSLAYRLIVWCTFIATCLLNGMLLILILGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVP2</accession>
    <name>A0A2T4BVP2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chondroitin AC/alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1432948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVP2"/>
    <dbReference type="STRING" id="983965.A0A2T4BVP2"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015722596" evidence="3">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="80"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="422" mass="46376" checksum="3A04CB1740809285" modified="2018-07-18" version="1">MHLSSLSLGLLSAAGVVNALPGLGLGDLLWPLKVPNTVVIDGWRLVDAKTRLLLGDRELKTALKHLTAQADSWLSQGPWTVTAKTKPPPNGTIHDYSSQAPYWWPNPDTPDGCPYIQKDGERNPEVDQYQDRVSVGKMFNSTYVLSLAWYYTGEKKYSQHAAEILRTWFLDDRTAMNPNLEHAQIIPCANTGRSIGIIDFSQEYTNVIDAVSILNAGPAPGWTKKDNDKFVDWNRRFLTWLAESPFGVEEASAQNNHGTFANMQIAALAVFTGDRSLAVQRTEIAKGFIDSQITRNGSQPQELARTRSFHYSNFDLCAHLRMALVARKVGVDLFRYKGPEGQTLFKAVDFLVPAAKGGADKWTYPELGFTRYAATDNVRAAAQEGDAVARGAVRKGLDAPPGGDIFGLRPAPEQLDSIATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW77</accession>
    <name>A0A2T4BW77_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1065369</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW77"/>
    <dbReference type="STRING" id="983965.A0A2T4BW77"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="164"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="133"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB73563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="24550" checksum="B82B44B361103E40" modified="2018-07-18" version="1">MTLYYTLVFGLLMAEMALFMLLLVPLPFSAKRKIFTFISESPVIAKLQYWMKITFFFILILFVDSLNRVYRVQLEVMAAHEHAVKGNAAAVMGSERLEVQARKFYSQRNMYLCGFTLFLSLILNRTYVMILEVMRLEDKLRAYEGTSQNTKESEKLAVAGKPGELAALKKKLEKKEQDLENLQKQAEQLNKAYSELSDKYAATQMDGESRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWZ3</accession>
    <name>A0A2T4BWZ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3-ketoacyl-CoA thiolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1403969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWZ3"/>
    <dbReference type="STRING" id="983965.A0A2T4BWZ3"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="290"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="414" mass="43624" checksum="5624CDF87FBADB88" modified="2018-07-18" version="1">MAVERIGSIIKHLAPGSSLSSIQSKNPDDIVITYAARTPLTKAGKGGFKDTSLEYMVYALLEKVRERSGVDPALVEDICLGNVTDAQAAYKIRTAALAAGFPNTAGASSVNRFCSSGLKAIADIAHAISNDSISVGIAVGAESMTNGRPTEELDEAVLKKSQEAQDAMQPMGWTSENVSKDFGIDRATMDKYAAESFQRAERAQKAGLFDDEIVPITTQVKDKDGQVKEVTLTRDDGIRPGTTAESLGKIRAAFPQWGPTTTGGNASQVTDGAAAVVLMKRSTAIKLGLPIMAKYVGSTVAGLAPRIMGIGPSIAIPKLLSIYNIGLNDIDVVEVNEAFASMAVYCRDKLGLDWAKMNPKGGAIALGHPLGATGARQVVTGLSELRRTKKKMLLTSMCIGTGQGMAGLFVNEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX54</accession>
    <name>A0A2T4BX54_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1404132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX54"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="16073" checksum="F9CB1FAB246CAA5E" modified="2018-07-18" version="1">MFYARPTSGHRGSRGKPSAHSVCLLLSPVLSQIDGFFDLPHCLFNNGLIHLFGESWPLRRTDILQLLLWCRIRKSLRAVKRRFDRAVLSRPMLALYKQGDLLHQSDRPSAHARILRCNSNHKLIRSINDGLQRHLQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX71</accession>
    <name>A0A2T4BX71_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1432779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX71"/>
    <dbReference type="STRING" id="983965.A0A2T4BX71"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134614" checksum="2AF9A5B562292601" modified="2018-07-18" version="1">MPSDKAAGAARTPAKAARPAAAAPSTTKQKSIMSFFQKSSPVSAPAAAREKVSSDHQHSSPLKETKANSLPKAKPSPKLSTPVPSSDAPGPSSSQENMESTVKRTKSRSIKASDSDMAPSSPVRKGKKAINYAESSDEDEPFAYGAASQARRRGRARNNVVDDEDEYGGSETAGQEEEEDDMDDFVVSDESDGEASRSKKRKRPSKPSSARKRTNLSPSAKEDTVQITSTLDDMDLDDVPTTSTAQQWSYDPDSTEKQPVVTPADRVVTRDPKMKEKAYMKEPDERYPWLANIRDKEKRPPTDPDYDPRTIFIPPGAWAKFSPFEKQYWEIKQDLWDTIVFFKKGKFYELYEKDATIGHQEFDFKMTDRVNMRMVGVPEGSLDHWVNQFIAKQYKVARVEQMETNLAKEMRERQDKTGKKADKVISRKLGCILTAGTLVDGSMLQDDMAAYCVAIKESVVDDLPAFGIAFTDTATGKFFLSGFIDDVDRTKFETLIAQIGPRELLLEKSGLSTKSLRILKNNTSPTTIWTHLKPGTEFWDADTSRRELTCGKYFVKDEDEEEVWPEALQEVKDNDLVMSAIGGLVSYLRFLKLEAPLLSQGNFEVYKPIQKNGTLVLDGQTLTNLELFSNTVNGNTDGTLFGLLNKCITPFGKRLFRQWVAHPLCDIDRINERLDAVEMLNADPSIREQFASQLVKMPDLERLISRIHAGACKPEDFVRVLEGFEQIEYTMTLVGAFKGGNGLLDRLISAMPNLEEPLAYWSSAFDRRRAREEKLMIPESGVDEDFDASVARIEEIKRQLDDLLTEKKTELKCKTLKFTDIGKEIYQIEAPKSVKIPSSWRQMSATKDVKRWYFTELTTLVRELQEAEETHSQLIREVASRFCKKFDVDYETWLKAIKIVAQLDCLVSLAKASMSLGEPSCRPQFVEEERSVLEFEELRHPCMINTVDDFIPNDIKLGGDQAKINLLTGANAAGKSTVLRMSCIAVIMAQVGCFVPARSARLTPVDRIMSRLGANDNIFAAQSTFFVELSETKKILSEATPRSLVILDELGRGTSSYDGVAVAQAVLHHVATHIGCIGFFATHYHSLATEFENHPEIRARRMQIHVDDAERRITFLYKLEDGVAEGSFGMHCAAMCGIADRVIKRAEIAAKEWEHTSRLKDSLDKAKTGCYIPLGILSDVGSLLGDKGDVGAQGVDVLLRAIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX97</accession>
    <name>A0A2T4BX97_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_122584</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX97"/>
    <dbReference type="STRING" id="983965.A0A2T4BX97"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="213"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="241"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB73866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="540" mass="59958" checksum="3D0939049D7976EA" modified="2018-07-18" version="1">MATNVEAEAPHNTFDTILLLDFGSQTSHLILRRLRNEARVYCEMLPCTTKLAELTFKPKGIILSGGPASVYDKDAPHVDPAIFDLGVPILGIWYGCQELAWRIDSANVAGGQIREYGHADVTIHNGANSHTNRLFAGLGETMHAYMSHFDKLVKLPEGFEVIASTQNSEYAGIAHQTKPIYGVQFHPELEHTPRGIEILRNFAIEICGAQPNWEMKDFIKKEIVRIRHLVGDRAQVIGAVSGGVDSTVAAKLMQEAIGDRFHAILINNGVMRLNECEQVKETLDHHLGINLTVVDGAELFLSRLKGVNEPEKKRKIIGATFIDLFQQEALRIEKEAENTPNAGPVEWFLQGTLYPDVIESVSYKGPSATIKTHHNVGGLPETLKLKLIEPLRELFKDEVREFGRELGIHRDLVMRHPFPGPGLAIRILGEVDAERVAIARAADHIFISEIRAAGVYDEMSQAYVAISKDRAVGVQGDARVYGYIAILRAVKTLDFMSAEPYNFDFALLKKISTRIVNEVEGIARVTYDITSKPPGTIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXH1</accession>
    <name>A0A2T4BXH1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXH1"/>
    <dbReference type="STRING" id="983965.A0A2T4BXH1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="260" mass="28641" checksum="2A6ADE423947B16B" modified="2018-07-18" version="1">MGEVLLRSHAHTLSTLMASAQTKGDLCDLELVCNGQTIMVHKLVACLQSPVIKAACTGSFKEASGRYEMKDCDFASVQRMVDFFYKGDYDAKSFDQPDSTQELSIHVAMFTLADKYLIDGLRNLSQTKFKAAVKTQEKPSVMPHYVKLVYDLDSECSRRLRGVVVEAVRLRVTALPFDLHVKKTLDGLMGDIPEFARDLAMSYIEQPQYMTGLFAGFGGGGYKKDGKSTTTAAPKFSWVSSSLAFGEAVDKKDDLAKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXR2</accession>
    <name>A0A2T4BXR2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RasGAP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1424606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BXR2"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="277"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1695" mass="194229" checksum="E1AADBF143DFB987" modified="2018-07-18" version="1">MSSSYRNSPRRQSHAVDLNAASSSINRNPSTTSSASSGYSYTSDHSTNSQSTSATSVYGSTGHKRGQSDVIARARFFETGEASSSSAGKGPDNIYGSIRQSLRPLPRTPTASSIEAPATPPHASRPRERGQSIDIGRLSLTQNDGSASPAATPRPLPPRPTSMFMSRGEPAIPEETAVPPSRHGHSHSAHIARPDLERLGRSSTSQLRTLSQLAKSEEAEDFSIISPAQEVAGLRGRRKLQRTDKTAGGRGPRTNYGWEGRNWMDKQRRFLQAYEYLCHIGEAKEWIEDVIQQTLPPIVELEEALRDGVTLAEVVESLNPDRRYRIFRNPKLQFRHSDNIAIFFRYLDEVELPDLFRFELIDLYEKKNIPKVIYCIHALSWLLFRKGIVDFRIGNLIGQLEFEHHELEAMQKGLDMLGVNMPSFGNMGADFGVPEPEPEPEPEETEEERIDRELAENEAMIIDFQAQLRGALLRLKLGEMMQGFWDEEAWLVDLQARIRGHFARQISDYRMQTRKSTILVQSLVRGFLVRRGLKKSDQDRKAAEPAILAFQSMLRAQKVRNEMQGLKNVMARCEGPIRAIQAMSKGFLLRKAQTVQQQETKQATHEVQNLQALARGMLMRNKVSKELRQLDKTTDKVEDLQALARGMLLRYQVSKELRQLEEHTPMVASLQAAVRATLLRAKIEQQQQDLHSFTDTWTSLQSAIRGRAARKEQEVLKAELAEHVPMIGQLQAAMRAAAVRREVSTLLDGLKEDEPAIIELQALIRAMFERRRVAAILDALDHEEPAVVNLQAQIRGFLYRQYHSALCEELASHNAATAEFQAILKAMMERARIDDLLTELLEEEDSIVIFQAAAKAYLIRLRFEEKKRFYEENMKKVIKIQSFVRAKVQGEAYKSLTTGKNPPVSAVKNFVHLLNDSDFDFNEEVEFERMRKTVVQHVRQNEMLEQYIDQLDIKIALLVKNKITLDEVVRHQHTFGGTSMGLLANSTMASTNQFDLKALNKSSRKKLESYQQLFFALQTQPHYLARLFKHIRVQATPEKESRRIELLMMSLFGYAQKRREEYYLLKLIARSIREEVESTTSALEYSRGHYFWAKLLANYTRSPRDRKYLRSLLGPLIRDNIIEDPALDLESDPMQIYRSAINNEELRTGRPDHRPLDVPREVAIRDPETRRLFIDHLRDLREICDQLFLALEEQVHKMPYGLRFVCSEMFQALRQHFTREPQESLLQMVSHWLWKFYLQPAVTMPENMGVIEKSLSPLQKRNLGEVAKVVGQIALGRPFGGENIYLQPLNAFIGESIERLQQITSDLITVPDAERTFDIDEFNDLYAKNKPTLYVKMSDVFAIHNLVAAELMVMAPTRDDVLREIMQDLGSAKSNENEMSAAGAADIQMFLTPRLHDLEDPEADIKALFMETKRCVLYIIRVQTGANLLEILVKPITPEDEDKWEALLREEFSAGSNSRGAYSDAKMADITSMSYYDLKRTALENIMQLEQMGRITKQNQYQDVLNAIASDIRTQSRRRVQRQRELDGVRLTLANLNEKAKYLEQQRKSYDDYIEQAMKTLQNKKGRKRFLMPFTKQYNHQRELERSGRVPKFGSYKYSVRALSEKGVLVSWTGTSDREWDKIDLTISCDQVGVFTIEGTRSHIQIPGATAQVPIEDMLQAQFEAHQFMTLFEGNLKLNVNLLLHLIYRKFYRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY03</accession>
    <name>A0A2T4BY03_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1464308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY03"/>
    <dbReference type="STRING" id="983965.A0A2T4BY03"/>
    <dbReference type="OrthoDB" id="3883941at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="409" mass="44342" checksum="2D8606EB5EB7BFDD" modified="2018-07-18" version="1">MISTRAATRLSLSQGRVALRAPKRQIRLQSTTSSSSTANAPPSSSLGAGIIGGIAGAGLFYGIYSFTPAGRTASKLNKAVKEAEKKYQEAAKKLQAATPSPDQAVDSIKQFAYSYVAWIPGGRAYVDAAFKDWETVRKQHGDEADKLVSDAYKQFQDVAKAGLSLEAASRAWDVLADLAKKIANLAGDALSDIVDNHPQLKEKLGGNIDQLKQMGEQYGPEAKKQVDETWKEVRDIFAGGFSASSIAKARELIDEKVKQVQKLGDEAWKKGLEEAKPYLDKNPKLKELLEENGDALKKGNISELFNKVKDAAKSGDLGSLEDYVKQAKEKVGGGKGSGSGWAALDQYLNLDKIPQGSEILSKLEEMGRIAQNHKEDGEKLLKETMADIQKVLEDKGRKAKEIADKATKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY62</accession>
    <name>A0A2T4BY62_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1380906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY62"/>
    <dbReference type="STRING" id="983965.A0A2T4BY62"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="10">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="358"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="399"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="519"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="616" mass="68552" checksum="01BAAE71DC48D3F7" modified="2018-07-18" version="1">MAGYNRPMSFSERRGSLLSEELTLNTNNSLLHQRVEKLPQQQRQLRGPPTPNMPTPAADFDQQLTGSAPDPPTPAASPGPAHCQPDWSDAADDEDFFLAKVRQHFQNSSGPQRTRILADLLNLCTSQQLSFVHQFVSPLLKKDPFTSLPDELCLRILSFIDDPKVLARASQVSKRWRDLLSDDMTWKNLCEKHDYGRRLSEVSPSAPIMTSRSSAYAYDADSEMSTSLPGDFPFTSHASSSMGFESVRPKIRSYKSHFKQKYLVEAAWRSGGTSITRNITQEGGVVTSLHLTPKYIIVALDNAKIHVFDTDGNSQRTLQGHVMGVWAMVPWGDTMVSGGCDRDVRVWDLKTGACLHTLRGHTSTVRCLKMADANTAISGSRDTTLRIWDIRTGLCKNVLVGHQSSVRCLEIKGDIVVSGSYDTFARVWSISEGRCLQTLQGHFSQIYAIAFDGKRVVTGSLDTNVRVWDPKTGECLAILQGHTSLVGQLQMRGDTLVTGGSDGSVRVWSLEKMCPIHRLAAHDNSVTSLQFDDTRVVSGGSDGRVKIWDLKTGHLVRELIAQGEAVWRVAFEEEKCVALALRQGRTVMEVIRMSRTLRSRWLAHFGFYILGARFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYW9</accession>
    <name>A0A2T4BYW9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_96804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYW9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="149" mass="16912" checksum="D128F32C52D98D97" modified="2018-07-18" version="1">MDISSSTSFLTPPFALGCCNISSSLLLSILLFSLSLSYLRQHILLRTYSCISGYRGYKALIRIYMAFYVLLLLFYFLYSYSSSSSAGVVHRPSFFTLIAFMKGHDHCILLSTTRRLQSLPSEKLSCLGPDLLPFFFHSLSEKSHSRMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ52</accession>
    <name>A0A2T4BZ52_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1471242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ52"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ52"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="202"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="697" mass="77060" checksum="97E2D3ADC768257D" modified="2018-07-18" version="1">MGPLAGSRSLTLRRHVGVKAFAAAIPRQVIYRHSRLYSQAAKDQAQGSSSKQDTILDLWRKYQANDALPGLGSDDVYVGFIGKSRNVSKHLSFADLTTPSGETIQVCSSAERDGEAHDDFRKVPAFSPVLIRVKQHEAADGESATSDGSSKKTVYLDSIHALNSVPKNLIVTPEVQFPPTKRHLQIRYHPELQARLQFRSWLKGSLTQSLLQKGFTDIETPTLFKSTPEGAREFLVPTRQKGTAYALSQSPQQYKQVLMASGIMRYMQWARCYRDEDSRADRQPEFSQLDMEWAFAGAETVQKDINDIVLAALTALQPARSYKEIRGEVIPVVAHIPPTPPPADQPVAHQFTNITFAESIAAYGSDKPDLRIPLRIHALPDLEPFRNFVGMITHLTNPLIEAFALPLNDCSPSEARKFVTKFMDELPPSLANNPDGKPQILIHDSRQPLSGFSSLGFEYESLLDLLTEKKGLQDGDLVVFQARDTPAGQYYSGSTRIGDVRNLLWKALVEEGLVETPRLGEPGSLQFVWVTEFPMFKPVEEGEPGQEGAAGIAASHHPFTAPLSQKDLELLFTDPLEAKSAAYDLVLNGIEIGGGSVRNHIADVQDFIMRDVLKMTDKRIKDFSHLFEALRSGCPPHAGFALGFDRLTALMTGTPTVRDVIAFPKTMKGEDPFVQSPSKLSNEQLAPYGLQLRSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ56</accession>
    <name>A0A2T4BZ56_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1337111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ56"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ56"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000025">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="481" mass="53783" checksum="6ED02B71DF597410" modified="2018-07-18" version="1">MSSFEKSVKGATKIKNAPPKTKYIEHILVGTHSGEAGVAEVLRALQNRLHDSTWTVVFKSLMTVHLMIREGSPEATLAYLARHRNMLAISNFADAQTQGRNIRHYANYLIERVRAYRDTKTDWVRAPESRLERLTVEKGLLRETEVVQHQLTALLKCDLLDQEPETEITIAVFRLLVLDLLPLFQVLNQGLINILGHFFEMSKPDADRAMEIYRTFTKQTDYVVQYLSTAKQWQHHTRVEVPKLKHAPVNLGRQLEEYLNDPDFEIHRRQYLAEQEAKKGSKTSKSKTTKSAVDFPKAPSPAANNPFPAPGSGNAPAKVESKPQANKGPDPDLIDFFDSIEQNQIPMQVTSNGAQMQVPMQGPDLAFQAQQAGLGFQPNNFAPFQAQPIQPQPTSTNPFARNAATEASAQQQQQQLQGQQPSSSLAPQPTGVTNPFRQGAFVNHTTGMGWQHNQTPIGGGLDHIQTVPVFPRPAQQTPWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZF4</accession>
    <name>A0A2T4BZF4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1464055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZF4"/>
    <dbReference type="STRING" id="983965.A0A2T4BZF4"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14854" checksum="A5D495265509F680" modified="2018-07-18" version="1">MLVGICGSICSGKKTVAQYLVEHHGFKHLYLRNPESVADQQATENSSPSLDGSNAASSNALAMSNGSTSSHVFSTAEELLDFVTRRWRSRFVTTDIPTEKVLDVFIRRPFFLLISIDAPLTPLLNMTNTNPNLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZT3</accession>
    <name>A0A2T4BZT3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1036130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZT3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="176" mass="19122" checksum="98956A5D562EE9D9" modified="2018-07-18" version="1">MAWRRGTGGRGEEEVLEGEREGLKSGVCVVVYACVGSGKHTQPVTAGQERVCLLPARVVGRRHPRRRWPVASVPGSTGSTSSDWMCLLDCTAPPSTRRLWFGVLTTSSTTSPVWLMDAGHTLGIEFQPHASRRLRRRALTSCEAPSGPSGLQQPVWCLSRAHSGHRRNPKSLSGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZV3</accession>
    <name>A0A2T4BZV3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1036707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZV3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="201" mass="22571" checksum="98EC23DCB137BEB8" modified="2018-07-18" version="1">MAMARHSVGHTGAFADALLHDSLCCAVNGAYIPTTAQTHHAKIRPPDLRRRRTLPRDMPFPYKSSRCMKSYVSGRGSFAMFLFSWDWESSFTLRALAPDMRHMWWAEVYCGHVTRQRDVRSDAVCSPSRRCRSPGPFGLDPTRCLQTQTPRGFMEFNILVGCHECIAKAHPPRPGGWAAGDGQHITAQHYISADIVTCHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0I9</accession>
    <name>A0A2T4C0I9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1357754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0I9"/>
    <dbReference type="STRING" id="983965.A0A2T4C0I9"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="7">
        <location>
            <begin position="364"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="993" mass="110203" checksum="42219CADA5E0F2F6" modified="2018-07-18" version="1">MQNIMAFLPLGVAIAFWTYGGFATSDPWLLSTNQFQGNHYQSSPYVANGYFGQRLPAEGVGYWIYRNESTGEYLLNSWPLDQPRATFGTISGFWDVQQNITHPIVPDNLKRGGESVISGIPEWTGLTVTTESGETYKPAVDASSVTNFHQSLSIRDGIVQTNVTWTPPSGNITYQLNYTVLAHRARLNLGIVRLDLSADQDARLKITDILDGAGAVRADFHEKWLEPDSTICTSVKPSGIEYLTAYVVSTVKFETTSKTGPDDLRRASETRRNGRGHPWISTNSSTVSQVWDWVLRRGDALTIYKFVGIASNSSLAAARDASILAGSTAWDDLISEHRQKWDAIWDDADIVIPGDQDLQRRTRASLFHVLTNLLPEDTGLDNSISPSGLSSDSYAGLIFWDADLWIYPSVLSLHPRFAAGINNYRQRLSDQAVKNAQYYNFSGALYPWTSGRFGNCTGTGVCKGYQYHLNSDIALAHWQYYQQTNDLRWLAEKGWPVMKRAADMFAAYVVRNASTGKYETIQLGEPDEFAYNINNGAFTNVGIKQLLGNWAPSAAQRLNIKVPKNWSHIAQNMYIPYNEKEKIILEFDGMDGTWMTKQASTGLINYPLQFQFSEEQARKDVEYYSSVNTADGPAMTWSIYAISEAQLQQKGCAAYTYLQRSSEPYIRKPFYQFSEAQLDSQPPGIENPAFIFGLNPAFPFLTGAGGFLQVLTHGLTGMRPSVDTFYLDPMLPPQLSDGIEVKGMKWQNASFDVLIEMDNTTITRRRTPSGEKRSVILEVLGGNPVAKEYRLGEGESIVVSTRRPNISYDPRDLALCRPVVSDSEWVAGHYPFAAVDGSESTAWQPATPDEASVIVDIVRLQEVSKVFLLWGGVPPSQFSLSGGKELNSEFEELTPPQKVEISAPYNSQNAQIVQIREGNATVVAFRSSVQLRFLKLTIAGSYASDGLGATVAEVQVMNEARGNVYGMETGNLISFAVESLWRIFSSAAASWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0J2</accession>
    <name>A0A2T4C0J2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1423170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0J2"/>
    <dbReference type="OrthoDB" id="3882058at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="70159" checksum="A46111B67DCEBF91" modified="2018-07-18" version="1">MATGYSVQPRQGFAGSASGSVDTHNQQRRRIPTRSTSPLREGGMSPQLRELLLPQVVHDRKSGTPMDEGVSLEPCDLSYVYYTTNSSSSDVASPLTPTFSNRGVPLRYSSSTSSLELPPQEGPASPIAQLAAASKSSIRQLPDVQEEPQEREEEHEHEGDYEVEEGEEEEDEDDYDDDLSDNLGMYCLCDQACEHLNTSQELLQGETTGEFDIDYDLGFLSDSDFSGDAQSSKKRTRLAGGESTFGALTSRIGHRFPSIARWKSQRKANSITGLMTSPATERSLENVLSGAASSRSSSMSSPTRQFPVLLDDAPMPPPAMPLYDGFASTDSLDMHAGELSREERSGIERDRAMATTPLLPPLLTDPLGKPPQPSQPSSPLQSPSIAPSSAVTELHSPRPAVPTPRQSLASKPSVSSLRHVSVLAELPLPLPPSILQDQDEWSDRLGHANFTITPMPYAVDEITAESVTKFCDDWDAARVAYTKHLVRTGEHYGQTSKTYGLTEAKWAEIERKWKLHYTDIVRRTQPMVSGSANSRSRSRGRGRGRSSSAHPAAQGQGQTMSHNDHDDIYAAMQWRGRRGCRPSAVPQMLEALDAEGKFPGRGDEDIVGPMQRDAYMVRARSEEKTPRFWRNLAEKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2C8</accession>
    <name>A0A2T4C2C8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_5233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2C8"/>
    <dbReference type="STRING" id="983965.A0A2T4C2C8"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="346"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="570" mass="63757" checksum="AC38034528032372" modified="2018-07-18" version="1">MDLTPSSQRAGSSSVEDGKVVRRFTALKEWLLRDPVSPRALETPATPRSPDVPKPAEPPTLLRNVAIQDSVAIITGRLGSLHTKTSTDASIRNTEDPTTHPSGTGISETTHQDQEAAFNSSEGGARVSESVHADLVPESQPRGFMNSAEDMPVDPSQRTDGFADFEAQSQRSRVSWDVSDGLSDGDNQDEPQQYTVSDGIKVSRTMLWLQLTSEPPALVHSCKSLAGVRHYTRDIDTETGHFLPEISYPDTLKTLHEGPSRDQRDIAWRQANMTAALQIDREIRSREWLAVKLKAQIKPQPEPVAIEPAATPRGNCVVRPATPQDFAAIATIINSESRTKGIPQVMEWKEVTAADVQKIYDSCRENMQPFIVATTARDTLLDLANWPVYSTQAYQEYLAFRSAQAKVPPMIFGFAYMMEARVGMLGSPCPGSRHTGQVKVIVHPDHRGKLYGSALLDRILVCTAPFHRRVLEYGWRCEDSSSVYEENPVFNRRQYAWIYIETFCDGRDDPTLKKASNFLEKFEFQEACYLRCAVKTDRYYESQWLDLVLWAREAQPRSNIADVLPGAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2K7</accession>
    <name>A0A2T4C2K7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_363244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2K7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2K7"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000173">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="137" mass="15021" checksum="9765005065FC3963" modified="2018-07-18" version="1">MTVKALRAIADGKNGLGAFVLQCKKLDLHYCDWAGSSKGMNGFIKSLLPKFAAAHPQIEFAVSPRPGKHPVIVGHYINGRTKPICVRNLSPYEILQKVELLRDASGEKLRRTNKAVLSTKPSVRGIWSPYHGKGMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2L7</accession>
    <name>A0A2T4C2L7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2L7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="125" mass="13618" checksum="9A7BB35220FEAE92" modified="2018-07-18" version="1">MLSFTPARKFPAPSSSITQEHQMSTKQATPNVILSKEYTHLTFSKFSAIRLGMARLSTPQGSPHPSVVSSEPSPPPSRLHATAPMSSHAHSRFLLKSKKARKSLQVRMVSFITPASSIVCLCITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2X4</accession>
    <name>A0A2T4C2X4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1357418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2X4"/>
    <dbReference type="STRING" id="983965.A0A2T4C2X4"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000149">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="49"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="382"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="563"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="414"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="502"/>
            <end position="503"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="785" mass="87219" checksum="72BB94D9FF07D14E" modified="2018-07-18" version="1">MGSDTDPGGFSFRGDFRENRPMFTLGYHDSKRETPLSELQYGYLLNQDFSVATTPITNSHFKSRVFKVVSDHLSTLKANGERATSEATASRADPILPPLTPEDTGMFPSQAVNTYVAYTSPWIDLCSKDPVIANISRQVLNLEINYASWCGVKSIIITGPCRDASKDGGSQGIAQYSRAVQEALTIAPAITILIHIPMYREPLAGSQTETLSSLNAEASKATEGEIDIFTTWDSWHQIRSVCRYNPRLLVALKMPRVMPEKDLQNRWFSEPLHYLTFGPEVFQKNKQGYPSLSKNHQDLIFTYMRLKNAPWILLCDVGPDVSHITEDGKDEKSAMTAADFPSLEEAHKPAFRVSTESNGHCDYLRWLEAQQPPFSALETPILTNFQDWLQSPLQPLSDNLESATYEVFENDAIKYDQYELAIAEALKDWSELKLPTSKPGVVVMAVAGSGRGPIVTKAIQAAQSTGVEVEVWAVEKNPNAYVYLLRQNALKWGGKVKVVKTDMRAWKGPLISDSPETGPVYGKVDILISELLGSFGDNELSPECLDGIQHVLAKPHGISIPQSYTAHLSPISTPKLYTDISSRAQNDPTAYDTPWVVSLYQLDFVAQRVPGHPRFQEAWEFSHPVPDSTLEAITARRSGGVVGGTGGSMAGAAGANDHNSRFCHLTFVARTRGVTHGLAGYFESTLYEQKSGPNQGRKTELSIHPERIGEKSKDMVSWFPIFFPLKTPLYFPADTELEVSMWRQTDDTKVWYEWLVEAWTWVGPSARVKVGSSDLCSSRKLACLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2X5</accession>
    <name>A0A2T4C2X5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1264290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2X5"/>
    <dbReference type="STRING" id="983965.A0A2T4C2X5"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="343" mass="37139" checksum="81EBDBE27DC17D74" modified="2018-07-18" version="1">MGSTAFGNFDDFCKDSTLPICNLLSQQFKNQTGPWGGCTLTGIPLSGGRHLGNLGSIILCGLGIAMAAFLIIKSDKKKAAVGRREIQLFLLSYILVSICEIFSVGEIPLGKTVRVAFSAIHIGMIIASTWILMLNAVVGYQLIDDGTPLSLALLLISAGALFVGTGYIALDTGLSWTGFWDSSYQLPNRNIALYVLYQLVPLIFIVAFFVLETVLVLRILGELRPMIYLAAAAVFFAVGQIFNYVVSKYICDGTNGKIDGALFETLFTLLAVGMVWVFWSSITEDDWPMPATETYTSPGYSTATAGYANTGYSSQAYAGPGYASQSYTSQSYNTQPYNSQPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C377</accession>
    <name>A0A2T4C377_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1423055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C377"/>
    <dbReference type="STRING" id="983965.A0A2T4C377"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="12239" checksum="1A14D6304FB6B398" modified="2018-07-18" version="1" fragment="single">MWPFSSSSCAYDACAPPNPHAITAASLLSALPFAGVFLAANAVAVRHVFPKLSRAAHDDTRDGEDHVLPSHAPAALRQAHAEHGSKSWRQRGAAWAFGTTVGLAATLGALIMAEIVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3B2</accession>
    <name>A0A2T4C3B2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1422197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3B2"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="56905" checksum="75237FD0CA6834D8" modified="2018-07-18" version="1">MAASLVGRASIRGGSETVQMVLLTFCTIGITFTWGIEMTYCTPYLLNLGLTKSNTSLVWIAGPLSGLIVQPIVGVIADESTSRWGRRRPLMLIGAVIVSASLLVLGFTREIVAALGGGDGKDVAPMRATVVLAVGAIYAVDFAINAIMSCARSLIVDTLPIEKQQTGAAWGSRMNAIGHMIGYGAGSIDLVRILGPGFGDTQFKQLTVIAAMAILGTTAVTCWAVTERVLVASKGPAKKQNDDSPFSVLRQIRSTLMTLPPRVQAICWAQFWSWIGWFPFLFYSTTWVGETYFRYDLPPGAAKSADTLGEIGRIGSAALMLYSTVSFVGAFVLPMVIRSPADDSYTHRPPRAMAGFLEKLNSAKPDLLTAWICGHLMFSAAMFMAPLARSLVSATFLMCLCGIPWAIAMWAPTAFLGIEVNKLSGAQDPSVLPSSRQSSRPSSSSSNSSSGELSGIYFGILNIYTTLPQFIGTFISTIVFALLEPGKSPELHDATEEVPGDKEGTNAIAVCLFIGAMSTLVAARMTYKLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3C4</accession>
    <name>A0A2T4C3C4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretory component protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3C4"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="210" mass="23566" checksum="C47C7A88047512F8" modified="2018-07-18" version="1">MSSSSYIDWSKTTKSKDYRGSTSFATFLIIGPTCFFLGILFASFPYDFPLLWTKEPVAADYYDQLETHLKFVHQSPPLIGRLLNIIMSVGFLGLFIKLFRPSEANFLFDGASLILYLIGVAVYVSNIVKGLRTVSSGFWHSEEFAASKGRFDGEIVLGREDSLKVLAASNTILALVLVGILVLQAGQWYAEKRDWDDEKEIAKKEAKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3U5</accession>
    <name>A0A2T4C3U5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1463014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3U5"/>
    <dbReference type="OrthoDB" id="10413599at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="107" mass="11964" checksum="963EED57AC474F19" modified="2018-07-18" version="1">MADTNRSLTGLANLRLFLCIVGIAKAINITIVEIASIKHKIRSHAGILYRRLAGALADLLKDPRPASMLEHPDDHIYHIKDMLLGKADASQDSEAWLRDLRLHMELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4C7</accession>
    <name>A0A2T4C4C7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1463126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4C7"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61321" checksum="0F3B631E642BD080" modified="2018-07-18" version="1">MKASVVPTSDDEFGYDFESDDEELLIQLASNNALPLKQPPDAIGPGPAPSTAIKTSASFEALQENKQSQRYALRSAAIPLSQVETKEEPSPNKDLKQAFSSAPSVDGTVIYPDLTGALKAIESVQSPPPTEISDDDDAEFEDERSPLQRFRSFPRRPLTVSDLTAGAWCELQYWYTLTRLPGGRKTRTPAMQQGSKVHKKLEDEVHTTVKIEILNKEDGFGLRLWNLVQGLRTLRDTGMTRELEVWGLVDGNLVNGVIDHLSYDNPNPEFEEELSSRANESSLNQSFISDYFPPPKSSKPGGSNRQVFLTDVKTRGTLSPISPAVIRPAKIQLLLYHRLLSDMAADKLDYFRVFRRYGLDPDERFSDTFMSQIGELHDEIFFDTPTSSAEEHTDQPNNNTTKQHAPQNDPATIDSSPGVPDLLKYGSLRELLTLVRDEINLTFPRGAASLGPILRVQYVFRDDGRELNAHDFPVSEQALDAYLAGDLGWWKGERRPRGVRIEEAFKCSSCEFAASCRWRRDQDEERVKRTQERVNRAKQAVELRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4N0</accession>
    <name>A0A2T4C4N0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1333136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4N0"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015598269" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23476" checksum="4F432B35194FF7E1" modified="2018-07-18" version="1">MVIGLLAITAIPTVTGVGQAVSAQKKANAANKEKEKFRLTAIVEGDSEDEDYETDFCVLKDGKLQVNVPLDTEFPGYAFCGYYFTYPSEEKHLGLVSTISDDPPMLNWIYVNKDTHAVEYGGRKDTLGHVIGPWGWSEDEKLLTLQGNGECFVAKLERGEEDGGSSSKPRWVVYWDPENEMLDALGADECKPVRLRRRMLLGMDSKYVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4X6</accession>
    <name>A0A2T4C4X6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1400960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4X6"/>
    <dbReference type="STRING" id="983965.A0A2T4C4X6"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="9009" checksum="CB8CBBEBFB8AEBED" modified="2018-07-18" version="1">MLIKVRTLTGKEIELDIELDYKVSQIKEKVEEKEGIPPVQQRLIHGGKQMTDDKTAAEYNLVAGDTLHLVLALRGGRYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C559</accession>
    <name>A0A2T4C559_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C559"/>
    <dbReference type="STRING" id="983965.A0A2T4C559"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="155" mass="16375" checksum="863C2FEC17E9CFC0" modified="2018-07-18" version="1">MAAVTEATAKRFFSSPLFAVVGASSNPAKYGHKVHAWYLNHKLPVTPINPSSPTVNVNGQDHPTLPDVKSLPRPTETSVSIITHPAITINVLKEAKSVGIPAVWLQPGTFDDDVLKFALADGTFEAVVYGDGGRGSEGWCVLVDGAKALKDAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C572</accession>
    <name>A0A2T4C572_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1332647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5370537at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015531696" evidence="4">
        <location>
            <begin position="17"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="901"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1968"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2012"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2060" mass="222248" checksum="0F65DA003CC5848B" modified="2018-07-18" version="1">MSLALQGALLVRLVLGAIFVAVQRPQFDPVCVASNTLLPVGVIVLAADMGIFGVLATKALMARRDNPGPARSKTLIFFTAAFGIWTGLSVPLFLGLGSTGYILRTVLPAVGLLILIGIVALSTTGLVSLPTTSILHFHKGGSFESANAEMEARNLPNFPPSQGATSGAPTVLPLIRQPSSGRGIGGVPIEGELFPPMRPQKVTYKPHSKKQMTEKAYNGGRIVISKPVMTDAAETNAFDHIQTMDLAAAAAKERERREKFIPFMSFDAMLTEPLFPKSRDLTANWQTTNGKSWYAEEGNSPSSRERAFATTSAVQLSPGMDETRRRSPRHPIQASAPSPVQDQTRTPRTASPRSAKMPLSKDNVKEPKSATAPPPFPSRTAAPAIPAAPSSIDQFMVDPRVASLPRSKSVKNDIRPSRRRPQSPVEAEEVKDTKTPIQRRATVGLPFNPRARATRMFTGQRGTGNDQPIMFFNHEQSSIPVPAVPEADDNSDAVSRKSVIHRPRPIPRKSTVTLAESNASDTDSMASTVEFMGTAASPIDDGFTIVSTPKLPMVSPVTVKTLSQSSLGTVAISPGSSALHKTVRKTSYVPDLPPLPTEFKAQQSKIVHDVAPERTATSIWTVAPNEHALFSVANNDESHSAHHHRRFSVNTQSSYEGTIGRNSVVFASDDKTTATMANSLNEHRSRHESADSELSLMLRAAPLPPAADETNVPGVPAVPNVFKDGRATPLSEEEEDAQEAAKELASWHRRIGEELPGFSTQLSDRRQRKLPVPKPLALSNSANITVVIQAEPSPEEPEQEALDRIHEQLKKLEDTKTRATISEKQRLDLLANLESEMGAQESQWQTLKIDLAATPSTVISTPGGAASVRNSADVNSTLAKARLSTGAGALLTALQDEANRRLSTASEQIPKDEVNRRSGRMSLISVSSRTLSQIGSPTPPDTDESGVDDSDNDSTTEDPDSAKEAPESSVLNAVTGFLALDEILSSSVESPNRPASPDEFEEVSLPTPKASSFSVPAQAEGEPKAVMTDSAEPESIRFSLTDLELSVPAPPPRPRSVARRPPRMSKRISALPDIVENPEPIAGRTGSLGIFQFAWGEKSDSATMPVRMVGLGGTMSSGRGWLSNLPPMPSLPSQSLASHSFFEDEEADNVLDNYEDEDYDDGFDDSTLWEIADLLEADLEGSRDDLFVVDDDDMEGPEDAPTTPASVMEIVKEEAQLPVPALWTAVKASEATRSWGLPQPTGKALEVFFAEASRPTARAVPRMKEAASALTSNSLWQASVGASVASRMWCEHKAPFEVEESKTVTVSLSVESPTTKEAVVSSLWSPISVPRSTFGLPQPDVQTWNTYIALPTRSVQRKASVQKSDELKSTSLWQPSTAAVAPSAALWAPKTLSVKASTQPLSAPSKEAKDLLWSYDHVKTVSFGLPQPEASVWAAYLVSEGRSHRGAYIPTVVSITSTSLWTPTIETRSEGMWMPQSKPSAALSVKSSPEPLTISSEVTKDLLWSSTPAKTTSYGLPQPEPSVWAAYLVSEGRSRRGAYIPTVVSITSKYLWAPTVETRPEGLWMAKPKPSAAPSAGTSPSPKAVKDLLWSSSPVKAVSFGLPQPESGVWTSYLVPEGRSHRGAYVPTVVSITSSSLWAPTIKAQPEGLWMAKSNPSAAQEKPQPTVKGAAGSLWAPSVTTKTSFGLPQPEANVWATYLVPEGRTHRGAYVPVVVTITSTSLWSPTIKAPSDGMWMPKSNAPAIQKLPEVQEEPQPVVEDTASSLWALPVPTEVSFGLPQPDSGTWESYIPRMTSTPLRRVLLSEPVSLESQALWFLPPKKEAAPGFLWCSSKPQVEKLQPIVKKSAGSLWTLPVISKASFGLPQPYSKTWGSYIPRMTSTSLRKVLVQEPSSIESQALWAPSPKEEAASGLLWRPAQKRAVPQKPVRSTTEAIEVLLQPAPTRATHARSSTAVLITKEQWNSAFKKISEQTQQWSQAPAEEPKNRPARSKSVKSRAFFDPAVMALIAELPSPTSFAPPSSHRPSVGRSKSVSFLPTTRRPSHSASSSFPEAEVRPSDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5F5</accession>
    <name>A0A2T4C5F5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1401157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5F5"/>
    <dbReference type="STRING" id="983965.A0A2T4C5F5"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB76807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="241" mass="25954" checksum="9CE9CB7D1FEF4E94" modified="2018-07-18" version="1">MTGKGKEVALRTDPIVIEPLAEHTATVIFLHGLGDTPEILFGPIEHWRGNGQVDHVKFVLPYAPVISFTAKGGEYMSAWFDMCWQKVYNGSLDALQSDEDVAGIFAGRDYIQSLITDEIGAGTPAERILLAGFSQGGVVAALAGLTYPESLAGIVLLSAWLPLIDSFGGYIPEEDANKETPIFLGHGVEDRVVTPELAKKSRDALAGMGFAISWDVYPGLGHATCEDELDDVEAFIDEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5V3</accession>
    <name>A0A2T4C5V3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_307506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5V3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="108" mass="12769" checksum="22A67679FE324A61" modified="2018-07-18" version="1">MNQDSNAGMLRSQPWRYPQHQVERFFRVVMCGVADWNVHAPRSKHRGSECRKQLNEKRQGRRTSDSQYRTGHLVSEHKSSSRKARKKRRTTPGTRPKKPEKDRGKTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5X2</accession>
    <name>A0A2T4C5X2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5X2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5X2"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098636">
        <property type="term" value="C:protein complex involved in cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046871">
        <property type="term" value="F:N-acetylgalactosamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052487">
        <property type="entry name" value="Galactose-binding_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="538" mass="61569" checksum="9388D214F6848DD3" modified="2018-07-18" version="1">MPAETKVDDFEMASCWPMPSTDLSDLPPSNLTKNGGDAEEDPEAMSLVVNKDWFWPVGAWLHVRFMNKEPDPHHEKMVQDAARVWEKYANIQFVFDNAENAEIRILFDGNLEGGRSLIGRYRRKETPQDKPTMVLGLAKDDNLFRRTALHELGHALGCIHEHSSPAAEIDWNRDEVIKWYAKYNLSEDWVENNIFKHYEKGSSYLNSDFDHRSIMVYRICPGWARNVPYIDWPNDLSDTDKMLIRRIYRPNMATTEFGRFDTEEHGGKKLSPLHHVKSLQLQNPQDKALDISLGLTQFDLECNDGIREVQLRAYADAIETTSFNLNLSSVEGSRLYAAAAISLASEQHNPAMQTGSYTTRPEDTQDGVEYMSHVTFKDPFNKAPGVVVWLKGFHFKPEECFKINAIADNITETGFQLRIETWDDAALKSAEVSWIAYEKDPPGIYSGKVELRNFREREADGKPHRPKERHRAKEQRLGQWRPQIVYAAVSKFEFEKGHNPRLSVTTAQTGQSSFEIDAVTWEDSDCQGVEVSYLAVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C642</accession>
    <name>A0A2T4C642_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1314627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C642"/>
    <dbReference type="STRING" id="983965.A0A2T4C642"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="203" mass="22835" checksum="3C7609E2217D0139" modified="2018-07-18" version="1" fragment="single">PDSLSDPSLPFPRLIVFDLDYTLWPFWVDTHVTPPLKINPTHTGATDRTGEEFTFYDQVPEILAVLPYLNSPNKIKLGVASRTSAPSLARELLKGIHIPPIASFADEDANNNTTNNKKSSSSATKKKVAIDVFDGGLEIYPGSKIQHFEALQKRTGIRFEDMLFFDDEARNRETERLGLTMKLVMDGVTWDEVAKGVELWRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6B6</accession>
    <name>A0A2T4C6B6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1462829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6B6"/>
    <dbReference type="STRING" id="983965.A0A2T4C6B6"/>
    <dbReference type="OrthoDB" id="4900201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015693222" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38298" checksum="C198538949BAB370" modified="2018-07-18" version="1">MKLLALSVVLSALQAVEARDPACRPAAPSCRFVSPWTARECSAIIRSHHIRLSTCEAPEKTVTKTVVVTHHPTFTHTKTVKPTPSTKTSTKVITRTDPVTQDVTTTVSWAPEVCTPTLTLAPSKRSDKRNGYKIPRDCSCFMTSTKSCGPHATKVVTRFEEDRPRYVTKTVTDRKRETITTTKTSIAHINGAPPPKQTVTSTTTSTVITTATSTSTVEQITTATEATTTTVVDTATITSTHPVTATEDPCNAANINKYLLQGPPSSPNVLLGFRTDGNNNPSTCCQNCVRNADCVFWKLYAGGSICEGYFTSRTAPVEGCTTNACRRGHPFMALSPQSDGNTYGMGQCGVFGVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6D7</accession>
    <name>A0A2T4C6D7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1315067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6D7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6D7"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF52">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="277" mass="30931" checksum="8F791BDDD8153A00" modified="2018-07-18" version="1" fragment="single">MTLSDQTNVGATKTISGAEYRRLIWKLDVHLLPPLFVLWFISLIDRVNIGTARIQGLEKDLGMDPLSNQFNIATVVVFIGLMLAEVPSNWLVKRLKPATVLCGECIILGIFTIAQGLLNNFAGLVAIRLIIGILEAGLIPGSIFLLSAYYPRYELQWRVSMLHVGNALSNAVGGLLAYAVAGIHSSSEWHGWRWIFIIEGVITIALTLLCWPFMNNWPGTAKWLKPVEKDVLEERIRVDGIIGRMDILDRRAAIRCLTDWKIYLSAFIIIGIISSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6E6</accession>
    <name>A0A2T4C6E6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1390508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6E6"/>
    <dbReference type="STRING" id="983965.A0A2T4C6E6"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="175"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="382" mass="43498" checksum="EB2CE48FD8B6C3A7" modified="2018-07-18" version="1">MSNDSISDFLAEQRDAAPEELQPLILNFEDYWERKLWHQLTDALVEFFNHDGSAPQRLAFYNVFILKFADKINKLKLVMLALKAATQCKDDRERLVFLQSVLKKVDTEDSQDALVFASVAVARVKLSLGELEDAKQDLDAAEKLLDSFDSVEAVVHAAFYDASASYYQRKADFANYYRTALLYLACIDLSTLSDEERLRRAYYLSVAALVSTSIYNFGELLLHPILDTLGRSEDNAWLRDLLFAYNRGDLAAYELLSDNIASNQLLKDNSDSLRQKIYLAALTEAVFRRPPHDRTMSFATISQETKVQPQEIEHLVMKALSLGLLRGSIDQVSQIAHITWVQPKVLDMKQIESMRNRLLEWDSNVNQLGNWIEAAGQDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6L8</accession>
    <name>A0A2T4C6L8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1400103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6L8"/>
    <dbReference type="STRING" id="983965.A0A2T4C6L8"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="209" mass="21067" checksum="85FAC2941009689A" modified="2018-07-18" version="1">MSFRGGSRGGGRGGSGSFRGGRGGFQQRDMGPPAQVLEMGKFIHACEGEMVCESINPKVPHFNAQIFLENKTAVGKVDEVLGPINQVFFTIKPSEGIQAASFKEGDKFYIAPEKLLPLDKFLPKPKPPPGAPKPKRAGGGSRGGPRGGGRGGFSRGGRGGPGGGGRGGFSRGGGGFSRGGGRGGSGGFSRGGGGGGGRGRGGFSRGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6M8</accession>
    <name>A0A2T4C6M8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_274762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6M8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="146" mass="16077" checksum="F138C6E448B5B454" modified="2018-07-18" version="1">MCFCGLVNGRSEAHPFFHSFIHTSCRYSTNSLAWFLSLIMSAGVLSGGVRILVVFGVLTLHDSSRDNGSYGNGQATRIQCIYTPASGKGTSFWLCFVFLGYHHHHQGLSCIGRSTAGLDLGWTRQQWRLVEGKESDRGHTGFACQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6V7</accession>
    <name>A0A2T4C6V7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger H2C2-type histone UAS binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_361065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6V7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6V7"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger H2C2-type histone UAS binding" evidence="2">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="585" mass="63699" checksum="B14C4EF075BED9C1" modified="2018-07-18" version="1">MPAAVDDPASPTIHRVSGQPPFPDPNNPVLPPDIVPRQVTLRDRQTVATIVPLASRHQVPASLAAYLCAQINKEIDGGDTYPLMDAFTADAFADFWFQNFGAVMLLGHIENLKSYPDRLIDAIIYGRDLAPGEAEELVSEERFDKIKYYLKYGKYPNGADRAEKSRLRSAATHYKLLDGDKLMLKDKEVIADPQRQYEIARGVHVMHHGGINKTTATIAEKYHWSRIKETVSDVIRACAECKELGKTPNPGGTKKSAAGASSSAAAAAAAAAAATAASTPTSAPTPAPTPVPVTMMSAATPVPTTTSTPTPILPSNGPPRNHTMPPSMGTTGRILALQSHESMLSLSPSSSPSPGAYANPSDISVIPPSQTFQAAQALHHHPQQPPPHQQQQHHHHGLPPEAHHHHHLQAALHHHHQQQQQQQQQQQQQQQSPLHHPGVHHAPPHHHHNPMLQDQPNQHEAHVYQPIDPQIINHHHHHPQAHHEMAFEHYHPHADFQALLSATEDVPTQPDDSVPPSVDTDLEMLIEHDAVDDDDGVVVGHADHGHVMDEDVMVDGLGGGPQVMRRIGHRDGRGIYDVNFGGPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Y7</accession>
    <name>A0A2T4C6Y7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1209355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Y7"/>
    <dbReference type="OrthoDB" id="4900060at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="58" mass="6285" checksum="22828AFC2C5E4C30" modified="2018-07-18" version="1">MLSRFLYDRTGVPDRLVARSYNATAPGPGYEGDAAELERYMSQSSAGVQSTGTTVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7E1</accession>
    <name>A0A2T4C7E1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1390791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7E1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7E1"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="308"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="437" mass="49384" checksum="1DD77BABF27E2EEB" modified="2018-07-18" version="1">MDKIPKFRRKPKPPVLETAIDRNGSVASDSMSPSGDSVMGQPQRAHHKMAPFRSLRLRGPSKRARDSPPADLTPTTPSAVVVAQDGIQSPPRPARPASQPVQHKSPPVQDRRRSVNQPPPVLPAFLTLSQQEKMDRYINIRPWAHNRVRLRVPDAEFDYVNASAITLTSPTDPRKPPLRYLAMQGPTVASFDHVWRMIAEQCPSPAVIVQLTNLVELDVIKCDQYFPMGDELPTGGQDTTWSVNEYNLWGDNWRADLTFVSVEELAGGAIEKRKLLLHVHGEQEPRVVWHFLYRRWPDFGVPTAEDVDSFLELMKLSREHTAPSAPRVIHCSAGVGRTGTFICLEHLMRELESGALARYDMPSERTDLVCHTVDTLRQQRRGMVQGEIQYRFIYQVLRKLWHEKYGGGDEEARSFEPAAKRLEVASPFTGNFRPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8U0</accession>
    <name>A0A2T4C8U0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1182093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB77991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8U0"/>
    <dbReference type="STRING" id="983965.A0A2T4C8U0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="11707" checksum="B9CDE8C6734E9980" modified="2018-07-18" version="1">MTEAENFEDDLFADLYEDTDAKPAAPVASAAQNADTKVHEQPEPAAAPAPAGDEDHSGYDAMNQDADDDEDEVDFNLGGGGPSNNNNVNSQEDTPATPPYGTVHKASAKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8V1</accession>
    <name>A0A2T4C8V1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8V1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015773225" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13127" checksum="2508DDBECC44B8C8" modified="2018-07-18" version="1">MLLLLLLYVWLPYTLVPVCTAASNPPRFICSSCLTAMMRVERRHACHCVRLGYECCAQSTVLLLGSQSSMPDCLFPSPTTIVIPAADVHVPRPIPSSGHLPAILSCYTLPLSPSSVALYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9K6</accession>
    <name>A0A2T4C9K6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_352616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01120">
        <property type="entry name" value="RecA-like_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056251">
        <property type="entry name" value="Arm_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23948">
        <property type="entry name" value="ARM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="560"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1301" mass="146936" checksum="755FE70BC7AC91E8" modified="2018-07-18" version="1">MIDCHEFDPSRTFSLPYCHSRQLCHELLMADTIERFSRPTSTSDLCQRFRRAGEPSTQDVTRRQKTARATKELEALQALQQSMISEFAQNPSEAYAIEITPLASLVDVDDYVRLFDIFHNVIAAAAVDGKIVDTELLRAFEAFLHCRQTGLAGRKLNLGSAMLSIQKALDGAVDAAHDQTKYNSIRALSAVLDAMNEVKVEGIVDVKVQSLLRRLGKLRDHKELRLAEAASYSYQALLAVPTDVNPWRKIGSSAVKTLMGGAKVAGSVWSFDPSKLVEGLVDLTEVPELISSIIEVIKLCGDLVGDASGTGKAFKTLKKPKDWYIALRATDGLIWANAPKHLEALLQHPGLPCRDPKDFLCGLCAQLEMARDLIHAQVCGVLEAFITAQASRTKSCRVLEWARLATRSPQLDSPNLPRYRRRKLYHANFERARVVLQQPRRQLLDNAWRNCHKVREFYADQVLRDYYTEDLKLLRIERLDGSKLSLDDCYINLAVVQTSGDSASRTDSDTPSPSPFSILRRLDIWEPPKSERVDLEAIFDKRSGAPVGAVRSGPSQDLPMRILIRGQAGVGKTTLCKKLVHDFLHSGMWAHIIDRIIWVPLRQIKSSLESGQDISSLLSRPLPGAEKAGEGTLGEALERSFKDDPTRTLFILDGFDEIYRQLHTPGNELLLKLINMPRVIITARPRGVNRELIQNIHLELETIGFYPIQVKEYIKKYAGDKAAEIHSFIEGHPVVAGLARIPIQLDAICYSMTAGTLDGNSPPETMTELYHAIETSLWNKDVEMLEKRREGNDAPVLKHEAQASYPNDIRRLCQAEVNALQALSFTGLINNIVEFDPVFLKGFHNVQNILTGNLPPAKAQPWFTDIDKLSFLRTSDGPLTPTTRSYHFLHLTFQELFAAQFFVQHWVLKKDLAVLDCVSQDSTSTKPEAFLLREKYNPSYDVFWRFVSGIIQLQRDKSALCRFFQVIEDEPRDLLGPAHLRLTMHCWAEVNSRAYEPACFADIRRSVRNTMKGWLFLESEMSTKTVQQLVGEPEFPEGLLREAAHMMSPDRNSLRTSFIYGLSARPRVSPSLVDFVVEWSRDFIDEYDDDEYDEGGYDLSLATTSLLWHAPRATPSTLALFSKLLDHPDRHVYQQAAVTVWKVAESRTETDYSPLIVKGLVECLGVRNDDTRVSVLSLLRTMLDLPAAAFERLQKMARQRPLWLKTREDVDTVPLYERPEKMKKALVELAETAKIESLQPSISDALKEIQETDAPLGDRAEIISNTLRRWKDKMYDSNYVVKLESSSVSLVRHTETMNLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA19</accession>
    <name>A0A2T4CA19_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1390078</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA19"/>
    <dbReference type="STRING" id="983965.A0A2T4CA19"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="453" mass="50583" checksum="0ED687CE13CBAC7B" modified="2018-07-18" version="1">MASSSSNVVGVHYRVGKKIGEGSFGVIFEGTNLLNNQQVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCGRRFTIKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGTKASNVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTAIKDLCEGFPEEFSKYLTYVRNLGFEDTPDYDYLRELFTQALKNAGDVEDGEYDWMKITKDSGKGWDSMKNHGAAYLHNPNARPGPSQMELHSGHRPGNTTSQQQAQNLTVSRLNAAQPPPPSPIKQMGSKRDRPNAPGALPAQRMSGTGLREMGTPTGSTQAQFQNSAQNLPQPVTSQQGPMTTAGQSSARPAEQPQPTGFQKFMKTICCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAK0</accession>
    <name>A0A2T4CAK0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1329534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAK0"/>
    <dbReference type="STRING" id="983965.A0A2T4CAK0"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="289"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="906" mass="97676" checksum="9A9C30F743758DD0" modified="2018-07-18" version="1">MDDLSGLDWSSDASGNKPKPKPMVVNSAYPPFRPSPSQSPFGAAQIATLSAQKPNGSTPKPAPAKTAQDSFSNLSFGLPKATQNLSLAERQAQLELEKRKKEEERRKLAEAQFGNGQHWDTLGSRGFTPSPAPQQQHAAPKSAANDDDDLFAAFNRDTKVDNASHYPPPPPVKKGLDLADPSAWGTAAASNGDGTFDVEDDDPFGLHEVKPSVPPTASQGAATSADDFDFLGDLARPVDEVRREQQAKQGSFRSEPGKPIEDDSSSSSSDDDDEPVQRNVERNVERVPRVNKDPFDKAVAQLVDYGFTPEQARRGLVESGTGFNAQAAANWLLDEAHRKSKEASQSRSSQSRSPAAAGSQTQRSDSRSPARGETDFAKTAAAMGNTLFKSANTLWKTGQKKMQQAVAEFQQEADPSQPKWMRDAQLARAQPTPPRADANVTDEALMLEARSRPLPARSTSGTRHPADPRAGPQISRTSSPAHSSGPPSRNSPVPRWQQQTAPPPMIPDARARLSRLTADDDDSFSSYVSASRRKKASPAPEPPKRTEPEPDLLFGSQAPTASQRTPSATQRPAPAAPSRPQQKPVPAPPRKVAPRPTRQIPPISPEALQASTRHRLQGTAHFKRGDYAAAHSSYSSSLASVPPTHPLMIVLLTNRALTALKTGEPKQAVADADEALKIIGPGNGQGETVAVRNEAGQDESRDMKELYGKALSRKAEALEQMEKWAEAGAVWKLCVEGGVGGATAVKGRQRCQEALNPKPKAAPKPAAKPRPRPSASSSLAPQKDSEAVARLREANQAAAREDDEKFALADKVDARVAAWRDGKRENLRALLASMDQVLWENSGWKKVGLHELVMANKVKISYMKAIAKTHPDKLPQDASTEVRLIAGLVFSTLNESWDKFKADNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBB6</accession>
    <name>A0A2T4CBB6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1352701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBB6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBB6"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051169">
        <property type="entry name" value="NADH-Q_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913:SF3">
        <property type="entry name" value="64 KDA MITOCHONDRIAL NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42913">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="406" mass="42794" checksum="8F611A6A4A84C37F" modified="2018-07-18" version="1">MAQRIVIIGSGFSGLYSALAARRLIEQNKDEIGNGIDVVMVAPEPRLVTRPRLYEANAAGMSAPLGELLAATGVKFVRGVVDVIRTADKQVEVVDPTGERTNISYDRLVLAAGSRLVKPKIPGLREHAFSIDTIAEAADLEAHLKRLAKLPSIPARNTVVVCGGGFTGVELATELPRRLRAILGMHEKVKVVVVEKADVIGPDLGENPRPIIAQALADLEIETKLGSTVASIDGDGVVTASGERIDAMTVVWTAGVEATPLTKQIPGDKDKQGRLLVDSDLRVPSTPDVFATGDAACARTDDKGNHTLMSCQHAIPLGRSAGHNAAADLLGIQGQPYTQPYYGTCLDLGGWGAVVCDGWDRKVLTSGGPAKEIKAWINSCVIYPPKGSAEEVLAAADPALNTVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBH1</accession>
    <name>A0A2T4CBH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1203339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBH1"/>
    <dbReference type="STRING" id="983965.A0A2T4CBH1"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="566" mass="62583" checksum="B4F10865B6E1B91D" modified="2018-07-18" version="1">MFQVLFASSDVSGMSEVSSSPSSQKAARACASCQKYKRRCDKTLPSCSLCTRLRRPCDYTNRQSENELKARIQELESLVANHVGTLSPQPQSTSASSTQGTGSLSSCATYPAALRFQKLFLDTDIQTRPDAPPPPSSDMIPAAVLLHLGDHAQSAIVMAQYFQTVHKWMPIISRVRLSSLADAELGGRMRADFALLLLAMKLIQYVPGSSSNAVRDRLYVCAKEFAASLEIAGVYTLLKLQANLLIATYEMGHGIFPAAYISVGCCVTQAMALGIHHREAPQILEQPRTWIDWEERQRVWWLVVILERYITSVGDNRPLLSADPKTTSHLPVNDDAWDSGQAMYPERLILSSSKHLSASPFARLAQASHLQGEVIKHCNDGTQSLSHVQNDVEVLNQVIWSFLDVIGKDRSSMMHFYSAVGVCLSALMKLCDHHSCDSFAIYNDRALDVAEMALAREIALRCQAIMKDCIAKAMAFVEVLGEMVQDQESIENLASLSPWFLDSIYQCLANLVYLTATSASADASGYTSQVSLCLELLRKVNRRWNVAGAYLEAIELVEQELKVSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBL6</accession>
    <name>A0A2T4CBL6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1398203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBL6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBL6"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14401" checksum="1C59375D6C9756F4" modified="2018-07-18" version="1">MSTLVVWNGMAFYRLEYSDQQIDLILSFIQNHNPSQIVSPASCSPSSALSATNGPLALRINVNVGKSQSFNILLSGPPGTGTILTAEAAADRTDRPLFYLQAKGLGIKAASLDTTISRVFETADGMKRCRPAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBQ5</accession>
    <name>A0A2T4CBQ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1398220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBQ5"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="21050" checksum="EBDE7968D4A4A507" modified="2018-07-18" version="1">MGSTEEQDFIISSITDASSVEKHLPSLRVLLQHCVNDEPDTSSIGFLAPLTDHTATSYWLDLLSSSVIGPGATTTLLIATAPGSDQVVATVQLARMAKETHAYKGEVRKLMVHPDYRRHGLGRRMMDEVERVARETFGLELLVLDTSMETPARWFYLRTGWNEWGICPGYAKSSSGLKHDCCFFCKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBT3</accession>
    <name>A0A2T4CBT3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1308871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBT3"/>
    <dbReference type="STRING" id="983965.A0A2T4CBT3"/>
    <dbReference type="OrthoDB" id="4900434at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="285" mass="31110" checksum="483DA657E21AF281" modified="2018-07-18" version="1" fragment="single">MAEEGHAQAITLFGARFYRDGRDAFGNYLAIQKSLEHPTSAQANDESRRAAASPFPDGLLGVSVQATFRTPELQYALFLMVPTSVHCRSAGNFISIDDDNQIEPDPRTTTVIAVTPTSGIVEGTLWPTTWIVRGPETKDCVEVFLVTFPSLRPADRGSFVTDEQTGRLFGDIIHYFAPSQTALVMPAKLVAEHARRVLDQRAIHGACSSLPPLSAPTPMRMQLKRVPGLGIVRLLSRFRGLGPLGSIAAVTIPKLPENLPNEEVRLRYDTELGDGPPNISITRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC50</accession>
    <name>A0A2T4CC50_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1370776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC50"/>
    <dbReference type="STRING" id="983965.A0A2T4CC50"/>
    <dbReference type="OrthoDB" id="5357513at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="34238" checksum="82D5A6762CEDFC40" modified="2018-07-18" version="1">MARPAIGAQASRLARDLPLSFSTTSARIPKLVYGTAWKKDQTADLVYLALKSGFRGVDTAAQPKHYDERGVGAGVKRAIKEGIIRREDLFIQTKFTSPGGQNDITPYDVNAPLVEMVHQSVQSSLEHFTIDGQEPYLDSLVLHSPMETMPETIAVWKTLESYTPHKIRHLGISNTSLQVLMFLVNHMTVKPAVVQNRFHNKTDYETDLRAFCREHKIVFQSFWTISANRHLLPSSPVREVAQKAGVGAVAAFYSLVLGLEGTTILDGTTSETHMKEDLEGIEVVGAWAEGEGASDWESALKGFKQLIGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD45</accession>
    <name>A0A2T4CD45_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1398746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD45"/>
    <dbReference type="STRING" id="983965.A0A2T4CD45"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="426"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="582" mass="63417" checksum="0F35BA5E23A00998" modified="2018-07-18" version="1">MSSMFKKKGGLAFKPKIPSARPRPAVPATDVQVEKDVAETEASSIAAVDSPSVQTEIETREGSSNVAGTSESEAVASPEPSSTTKADSDAASKPPAQDVSGLKPQEEPSPAIEQQQSPPEPSTTQPSPPPPSTTPPSQEPEPATTSPQPSEQPSAPRPRGPLPVIADDNIAPELRDPPRAPQETQKDVPEAESNEATPAPPPGPKTRSRRKAPASADTDPEAPPKKRQRKTPANEDGSTAPKPRQKRKSPTQDGTATPRTRARKARSVTPEDAETQVVDLQNLKMTDLTKDLHIGKKFSRHDELRERERQARIKSKLKKLMGDGGSRDGSEAPLETSPDDDHPSVKSKSATPAAAAALPSSTTTPAPASGPQFRIVDGQIIIDQSSLVMDRHARAAATRGDMETVEENDFTRLITSSSFMNTSKLKGPNIWTEEETELFYRGLRMFGTEFEMISKMFPNKQRRHVKLKYNREERHCPHLINAALIGEKTVRIDIDEYKAFTGIEFESVESIEAEQRKIQEDFEAEQKRIADEQAEVMRKKREELFADEDAAGNGKKGKKGKKKGKQAVQYGLNGEPILAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD68</accession>
    <name>A0A2T4CD68_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1326614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD68"/>
    <dbReference type="STRING" id="983965.A0A2T4CD68"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="130" mass="14784" checksum="D3A1D5C591D7A5FB" modified="2018-07-18" version="1">MVRTSVLHDALNSINNAEKAGKRQVLIRPSSKVIVKFLQVMQRHGYIGEFEEVDDHRSGKIVVQLNGRLNKTGVISPRYNVRLADLEKWVVKLLPARQFGYVILTTSAGIMDHEEARRKHVAGKIIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDA8</accession>
    <name>A0A2T4CDA8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1350419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDA8"/>
    <dbReference type="STRING" id="983965.A0A2T4CDA8"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB79567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="464" mass="50377" checksum="EC58A29FEAC82A14" modified="2018-07-18" version="1">MEPNNHHNGLNGQKADNLEVAIVGGGLTGLALAVGLLRRNINFTIYERAASFGELGVGIHFTPNAERAMEALDPRVLQSYVDVATHAEGGFLSFVDGSYVRNEGYAKVSVDDDLLFQLRMGKGYKAARRCDFVSQLVKHIPQERVQLLKWLQSVEEDAEGRAVLTFRDGSTAKADVVVGCDGIRSQVRSAMFGSGPSAPKAQYAHQLAFRGLVPMAKVAATLGPEKTSRAVGYLGPGGFVLSVPLAGINMMHLEVFVMDPLDWSDTRSKPDKDNDEDDVKRYVLPSTRAEAEKAFTEFNPTVRSLISLLPETLGKWAIFDMLDSPAPSYALGRMCLAGDAAHAATPNQGGGAGAGMEDALGLAEILAALADRAKSGARVGSSEISEGLKIYSDARYERSQWLVRSSRRVAQLFTRQRSAGQGGEQEEPISREILERSRQLWDYDVDAMVDGALRRLTSKLSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDT8</accession>
    <name>A0A2T4CDT8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1350674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDT8"/>
    <dbReference type="STRING" id="983965.A0A2T4CDT8"/>
    <dbReference type="OrthoDB" id="5425061at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="288" mass="31962" checksum="A31074AC9F1E2AC9" modified="2018-07-18" version="1">MFDLPDAKRVRREELHASDESSWSESEVDAELEARLNAQIAKSLGIDESAYRPPQPPTTLPVLQRPQASGKRGREALSSDSESEPGIPVDDDSTPIDEGGEAEDEGYAFRLFSTAGPAPKVVLEDYDKVVEGKLLRGRPLSYYMATEVSPQKKREYEVAAVSGEDVLARSKVRHWGLELPWKVTSIKITRKARPGEIASHARSESEQQAGRKRPGKKSRIAMRKKARAQAQAEEEAKKKMASKEEQIKEKKKRLNRLKKLRRRAQKKAEKGENGEGGGGSGEGSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDW9</accession>
    <name>A0A2T4CDW9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1327339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDW9"/>
    <dbReference type="STRING" id="983965.A0A2T4CDW9"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="45"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="49"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="296" mass="32046" checksum="ED7B0D0BB4F9CAA9" modified="2018-07-18" version="1">MAYSADTPGLKYASHQYGQHNLQRVGVWQYENAPEAADSAPSYWIIFVHGGGWRDPRNTLHDFVPSIKHMLALPDLLPTSAVRGFASIDYRLSPHPQFPQDPASTPANDLRQALHPQHVQDVLAALRLLDAEYGIGSNYVLIGHSAGGTLVHQVIMNNDASCAWGPAAPLPAAIVSISGIHDLRGLAERHGGVYETFTAGAFGPDRQAWDAASPAKFAGNFKSLWPNEPRLVILAASAEDTLIDVAELDIMEAKLVKDGIKPIVIKDLQLEHDSIWEDGAQVAALAAKAVAKLRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE07</accession>
    <name>A0A2T4CE07_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_2479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE07"/>
    <dbReference type="STRING" id="983965.A0A2T4CE07"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="192"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="395" mass="43931" checksum="6B34A2E44F7D9FAE" modified="2018-07-18" version="1">MSTQSIQIPGLTLLNNLAPHAIAATPDGGLVGAAAKNPQPKTKAPYVPPRKAKKENKKAKARRAQAEAEAAAASHTANANAQFFGLAPAPGQFGFSDFNNHNASFGLNFNHPSNFGLNFPTPNNFGFDMNLFQNNFFNNMTPNNFTATPPFNNALKNLPRDERVAPSAASGGIPEPTPLYIKTSLSQPVTLRQPRRIFVIMDLNGTLLYRPNKRNPFNFIQRPHARQFLDYCVDTFHVAIWSSARPENVDKMVSQLLSPAQRSKCVVIWGRDRFGLSPADYSSRVQCYKRLSAIWDDPQVRASHPDAAQGQRWDQTNTVLVDDSAEKGRSEPYNILQLPEFEGLANEPPDVLPQVHDYLNTLCYQANISSYIRHHPFSIDANYRLPQCQEDNGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEE8</accession>
    <name>A0A2T4CEE8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1397176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEE8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="81" mass="9188" checksum="CA58525DFD759696" modified="2018-07-18" version="1">MKLQIPGPFKRGDLGPALSVRTVARSWRHRRWSYRGVNSLMKHNPTGGPASLLWFAVALTPSFSVDRASYNRDTARDFDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFU3</accession>
    <name>A0A2T4CFU3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbon catabolite repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1436042</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFU3"/>
    <dbReference type="STRING" id="983965.A0A2T4CFU3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="77"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="402" mass="43608" checksum="5AD5F4A2496B59D7" modified="2018-07-18" version="1">MQLSQSAVDFSNLLNPTSAAGQDSGAMSTAAVTVIKPNGPIPGTQATETANELPRPYKCPLCDKAFHRLEHQTRHIRTHTGEKPHACQFPGCSKKFSRSDELTRHSRIHSNPNSRRGNKGQQQHQLHHQGMPHPMHVDGLMHPPAAPKAIRSAPPSTLVSPNVSPPHSYSSFVMPHGPISHYGRGNDITMLAKAANQIERETLSGGPSNHNSRHHPYFGQGVPASRGHPSLSSYHMARAHSNDEDDHYHGSLRHAKRSRPNSPNSTAPSSPTFSHDSLSPTPDHTPIATPAHSPRLRPFSGYELPSLRNLSLQHNTTPALAPMEPHLDAPQFHPQLQANTTRSPGMSLTDIISRPDGSQRKLPVPQVPKVAVQDLLSDGVFPNSGRSSTTASLAGGDLMDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG00</accession>
    <name>A0A2T4CG00_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG00"/>
    <dbReference type="STRING" id="983965.A0A2T4CG00"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="524" mass="59948" checksum="C8C7821DB78307A0" modified="2018-07-18" version="1">MAHLTTLPNEILHNILQWMSPRDLGSLPRVCRALHGFVKGNQKLCEDIYLHNFDSPPNDERLDWETELHDVVRLENICLREDVEDKEDELSFVYEVVNRMLKHASPTGHAVETSDTQHASRNADFLRTLFEDEANQVAFLQKSSLFERVYRTQHHQLPPTVLNEEQRRQSAKLHCLYGRPILKTGRLRSARTYPYACSKVYDIREYTHGSRWGPFMADGSDNVDWEKVEAIQIVLGNNIYIKKLTRLFSDIWDNPFSGSWKGSFMSAPNLDKTSLDAMDPYGVTGTWYRIVCFLDYNDFFSYNFANPERDGSPLHTLDVGEATRLIIMRIHVTKIEQPGPDSEYSSELPIVHYEGISRPLDDSWDDNASSDLRGTVGLTREGEVRWTSVSIFQGQERWKSEGVQIGGPRSARGVIGNWFDRDYDPHGPCGPSAFWKASDSETAHGKHAVLPRNFLLWSALLQMEDSDDPEGDMEYTMENEEEDEEDDSESEPVANELPELLMDAELEIIEITHQMEEPGPSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG51</accession>
    <name>A0A2T4CG51_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1388792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG51"/>
    <dbReference type="STRING" id="983965.A0A2T4CG51"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="833"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1024" mass="112765" checksum="2B605B35EC48F978" modified="2018-07-18" version="1">MCLVTYSKKAKLLNWPWSTSESPPVLDRHELCHICLDRDFRSKSGNRWHLDCFRCTTCGSLLDSDANLLLLGDGSLICNNCTYSCTACGNKIEDLAILTGDQAFCSTCFRCRNCKRKIENLRYARTSQGIFCMDCYETLMARRRKKSKAAAAAKAREKDQPPAVPEKSLPALPPGAIPNNAFSDDRVDPDGPTELSPRPRTGHRHNESSSRGTSKASRSPERAAAEGKDGLSLPSTTYRRNRNSTITSNNGDGGDGFLISVALDTGAQSPNGTPKDSAGEAGKKKDKEHMNAPRPTMSDKRADSHSSATHIAFMGAAAAAAAADPSQSKPTSRSASKSEPKASSSSADDVKLQDAPKKRRPTESRSDSSQSVHQQHDGTPSRTGTSTPRKDSTSQQSDPRKALDSTPGSRSSYDSKAADDEISTAKIGPRSDSMNKTIPRKEVPSASTRSVNGSPSTAQGKSSSEDASRQRPPSRSGATDKALTDTYMQPRAAPVPPSSYTQSPPKEPAPPVPKGAHASPSSPKLPRWSSGADFTMEEDMVRILGADEGSSSILRRVSNAVRHGRTSSVESNQNLSARGTHTRSISETTRGAISPRWPKTQDDANGPDVGSPSSLTAPDSAAVLKQQLRSSEQRVAELERQFGAEKDLLSINQKLIEKRKTVSVLDTQTEIMIRQLEVLAGYVERAKETQAPIDVKELEESAIKEFVEKLEKVKQSFTEELERLHEERDQLVEEKNHAVTERDRALMEFEQLSSKNAQLADMNNDLTHQIQERFKSQIGNDGKPNGLGIYKGGASSINLDTASVTTGTTLVPDEDPTIVEHGPTVVHVRKGQNRLRSERCEYEHRQIPSVVTRCIEEVELRGMDQEGIYRKTGGNSQINQIKEGFDKDEDYDISDPDLDITAVTSVLKQYFRKLPNPLLTFDIYEKVLESNSIIDEAERCSYLHKVFTSMPQSHRDCLEFLMFHLHRVAIREPENLMSPKNLAVVFAPTIMRDLSIEREMTDMHNKNLAVQFVIENTHRIFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG59</accession>
    <name>A0A2T4CG59_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NadR/Ttd14 AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG59"/>
    <dbReference type="OrthoDB" id="6118920at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="1">
        <location>
            <begin position="15"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="24031" checksum="CC9175554E8B52B8" modified="2018-07-18" version="1">MGTVSTPQSFNPRNIYIIGAQCTGKTSLVNALEASFADRFTTTPPAIVREVARSVLKTHGFTASDITSDPGRCLQLQSFILEAQLSSEREALARNTWIISDRSGLDPIIYASRHVGEEAAKFLTSSDHWQELRERMSQSLVFVCETVEAWLVSDGVRLMPRDVEDWMEYDREFCRMLEVEGIGYQKIPRSVEKLEDRVAFVWSRWEKATFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGD5</accession>
    <name>A0A2T4CGD5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_198846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGD5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="18480" checksum="5DBF485473E1346C" modified="2018-07-18" version="1">MKAKAFGISKRNAGPPNKLVPSSISQGTPELVLSGAPVGHIASRCYTNLLTAQHVLGEGVFTFGSLGTPCLPRRLSSARRHQGPWGDPLAPAVIRASTAAVWFGSTNGGRTKGPRGPYRGSLCHHARRIVASRMSRGTSGCRAMFEVDERGRDVRMFRRPDPHQDGPKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGF2</accession>
    <name>A0A2T4CGF2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1428264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGF2"/>
    <dbReference type="STRING" id="983965.A0A2T4CGF2"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="195" mass="22206" checksum="C861D2596C665014" modified="2018-07-18" version="1">MYTNLGTSRKARDLATNPHASLVFYWPPLQRQVRVEGVTETNSREESQTYFDTRVRGSRIGAWASRQSTVLTPKPRTKSSSSSSAAAAVGSENAQQQQANGVDSNNPDQAVADGEEEEEDDGRAQLEEWVHEVEERFKGQDKIPVPDFWGGLRLVPQRVEFWQGRESRLHDRFVYEWEEGVDGKEGKWRLERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGX2</accession>
    <name>A0A2T4CGX2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cis-golgi transport protein particle complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1428392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGX2"/>
    <dbReference type="STRING" id="983965.A0A2T4CGX2"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="771" mass="85932" checksum="7D4570A91E779A4E" modified="2018-07-18" version="1">MPRPQDDSSTEPIQALPAAASAAKFSYMRHSTSTIEPFPTSPSESSLVFRRSNPSAASLYASTLSPPGSRSMSPAGRGSPSRVLSGTVFDIGQNRGLPENVGDDPSEPLNLILKSFVPHVSVYASRDTEALIREKGFQHGLWELLRPFGESVQGKVNIRDSNGVGRIVEDFSIRFTRFGENIERPDALTSGSQQAPAPRSQNGAQERDTGKRSAINDIEAVVERHLSYAEESFLGMPHQSIMTKNGSDPEAASPYYALYLRRLLSGLPISPHETFAHPVACIIAISSRNAAPIEELRRLYSETSQGERRLPSWVDGDYLRYYVLVHDEENDDIARSMGLFEQMKRHLGLHCHLLRLRCSQSVETDDDSIPLPRSDWMSAAEELAEIRRSENDEDFEDPSRYIFESDATAIRTFVREMVTQSIIPTMERHATIWNDQVASRRRGLTGRFMSLSKRWTVFGSTSRSSSSGTNTSKDGYDPSGFYQADTSEAIMRKLADFAFMLRDWRLAHSTYDLLRSDFSEAKAWKYHAAANEMAAISLLLMPQQLTSKSRAETVDQMLESAFYSYNTRCSSPYGATRTLILAQELLRLRGGSSIDDAARWCTRLLESKILGSIGDALLKERLAICYASKSGVGSWSWGSRRRKSAAWSVFAARAWAQQSKFIPAQRCLNEAKRTYETLPHGQGISRFASARETMDSLQRELTEKLEFHSGHDRGMSEDAADGGIDEESEALVDTRSRRASNLARGGTETAPLHNEDTSKDTNEAIDQEGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH09</accession>
    <name>A0A2T4CH09_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1322717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH09"/>
    <dbReference type="STRING" id="983965.A0A2T4CH09"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="62"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="804"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1148" mass="128658" checksum="D01DAED0BB0FB3E1" modified="2018-07-18" version="1">MAGSGDITDFEVIENQKENIQALPGGRSARKLAGLFSSPLHNLSTPTPTDTRNINEAIRAEFEAEIDNISESDDPLDVFDRYVRWAIDAYPSAQATAESQLHTILERATKAFISSSQYKNDPRYLKLWMYYIQLFSDTPRETFLFLSRHGIGESLALYYEEYAAWLEGADRWAQAEEVYKLGIEREARPVQRLLRKFKEFGERLAQHPDALAEPSSPALPTVRPALASKTDPFASSSHPVDPQAPRQTSGVGGSSSRPAKPKMAIFSDADAQQPAMSSRDAASKGWDSIGSLSDRKKENTMEPKPWVGETLKAGGRKPGAGGTKLAVFRDPSLAQIQTIVVVPSKHQVTVHPQTGKREYIFVDLAAVYPTPEEPGTELSFEEIIAAHRGWLDRLWDTDMESENGTANRMVPLRDMEHLSDQMVIEQDCDPMDLDENGVAQEKPREPRGGRRKKMMEVNETQIIKAKLDSPSGPKFRKKKAAEPTMTIHTKAATDDIYEIFNAPLKPAPVEGEETGDDYDDDDDEDEDDDDDDDGDEDEIVTDADFASDAESTGTTRQIQQGEQERRTWLKILTTLDIDVTSHSLARDVDEVFSEDEEMEPPRTRTIFIPLPPEDYEPPTRPYRDAATMANNRLPFMTPITERTEYSMDVDMDRAYQFKTPSKRDGRATPIEEASDSEPSGSPLRDFFPEESPFAKGREPLGSKAAKALSKTGPNRGVPVKGPIVKEAQCSPIDDDIRRTILTNIQPPLAAYPGFHDHRNQRYERGGEIRRFAKAVSRLGKGNQDRPGLGLAPVVIRFADCHSRYTVKRELGAGAFAPVYLVENSHPDQEDGRVMMGKGAFAVSQRAAVEALKMESPPTPWEFYIMRTAHARLGPRHRATASISVAHEMHLYHDEAFLFLPYHPHGTLLDVINLFRAEPSGVMDEQLAMFFTIEIFRTVEALHSKGVLHGDLKPDNCLLRLDAKSAFSSSDHGLSSKWHADGSGGWDSRGVVLIDFGRGIDMKAFGKDVEFVADWKTTAQDCPEMREGRPWTWQIDYYGLAGVVHCLLFGKYLETVRADQGGLGRGGRKYRIRESLKRYWQTDIWADCFEVLLNPASFAAHEEGGRMPVLRSMRSIRERMEAWLEDHCERGAGLKAMMGRVEAFVKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH19</accession>
    <name>A0A2T4CH19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1417642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CH19"/>
    <dbReference type="OrthoDB" id="5244639at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1339"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH24</accession>
    <name>A0A2T4CH24_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1387431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_P450"/>
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    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
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    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p450"/>
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        <property type="entry name" value="Cytochrome P450"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        </source>
    </evidence>
    <sequence length="300" mass="34234" checksum="A503FFE90A98DE40" modified="2018-07-18" version="1">MGFIELLAQHVSIKAICLVTLALWAARMTINRIREHRKIKSMGNYGHTLQPRLPFGIDFIYYGVRSTIAHKNLELWRDMFFANGAYTCEMRILNERVVLTVDPENIKAVLATQFHDFGKGPDFKREWSELLGDSIFTTDGAQWHESRQLLRPQFTRDRLSDLHCFENHIQSLFKAMANGGPLNGEGQEVDLSRADGRRLDISELFYRYTLDVATDFLLGSDVKSLSTPKHDIAIAFAEAQRLQNIMVRASRLRWLTPKGAYRANIRKIDAFIDGGEPLLKSDIILSPGQGVHVAFWEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH94</accession>
    <name>A0A2T4CH94_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1001625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH94"/>
    <dbReference type="OrthoDB" id="10542839at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="11439" checksum="63E73411C3F586B3" modified="2018-07-18" version="1">MQLPCSNNRDEHLCNLFYPQDTLQPAIKRHPPSAAGKMVEHFSHQVATPRIEICKSCPKSSPPGTMRNLQNAVFLARKRIVKASLYHFDLMVSSLLLVDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHL7</accession>
    <name>A0A2T4CHL7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">M440DRAFT_1396172</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHL7"/>
    <dbReference type="STRING" id="983965.A0A2T4CHL7"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="26"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PTB81012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="261" mass="28855" checksum="2C79D721F7124A2E" modified="2018-07-18" version="1">MTATAAEAAAAPHEFPLPKILTNPASTPPTLITQGAEGRLYKTTYLLPDIPCALKYRPPKPWRHPILDQRLTKHRILSEARILSKCRRDGLRVPDVYAIDEAAGWLMLEWVQGTPVRVNINERLGSRTEGIEDDEELKDLMRRIGAAVGKMHSIGVIHGDLTTSNMMLKPPAQQSADDGATGLEGEIVIIDLGLASGGVHDEERAVDLYVLERAFGSTHPRAECIFGEVLDAYRKSYKQAGVTLKKLEDVRMRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHN5</accession>
    <name>A0A2T4CHN5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHN5"/>
    <dbReference type="OrthoDB" id="4159136at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="16707" checksum="D24DE48E2B6DBB6B" modified="2018-07-18" version="1">MPQDQDALRKVGRGGAGNYVPSKQADEASKDLEAQQLKAAATPSQHPHGPAKVGRGGAGNFIDPRYAAAQEEEDQKAAELRTHSQPHRAGWSGRGGAGNFHADLAAEEARAREEEDGRSKAELDRKIKEAVEGALKLPDKVHHHVHKEDEEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI52</accession>
    <name>A0A2T4CI52_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1323185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI52"/>
    <dbReference type="STRING" id="983965.A0A2T4CI52"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="492"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="588" mass="64388" checksum="CB417D29432EAE20" modified="2018-07-18" version="1">MAGRFVRASKYRHIFGKPTKKEFCYDNLRISRNAWDTNLVKANAEYLSVNWESSGGGAFAVIPLNEKGKAPDQIPLFRGHTATVLDTDWNPFNDHIIASASEDGKVFIWEVPEGFSLYTDAEVIPDVSPVSKLGGHTRKVGQVLFNPAAENILASASGDFTIKLWDVGTGQSHLTLQHTDIVQSLSWNASGSLLVTTSRDKKIRVWDVRQEKPVHEAAGHTGAKNSRAVWLGEHNRFATTGFSKMSERQIALWEPGRSDPIGGFQHLDAISGVCMPFWDEGSNCLYLAGKGDGNIRYFEYENDKFEYLSEYKSVDPQRGIAFLPRRAINVHENEVMRAFKTVNDSYIEPISFTVPRRAETFQADIFPPAVGLRPAVSAKEWLEGKTGLPPKIDLESIYEGTAPKEVAADYQPPAPVVPKAEPKKEEVKEEPKPVARAPPPSVSDQKSSIAAMANKYQDAEEAEPKEEEPSSFDEEVKPAQRNPLPIRAETKPAAAAPATSAPAPVKPAASAASSTPAAAAPASDASATSLSEIKELIENQTKVISAQNDQIGLLTSEVESLKKRLGSGSQDQSERIRQLELELEEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIC5</accession>
    <name>A0A2T4CIC5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1466865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIC5"/>
    <dbReference type="STRING" id="983965.A0A2T4CIC5"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="514"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="698" mass="76410" checksum="87B876E1B3C18B5C" modified="2018-07-18" version="1">MQQRREEILAKKAKLAELKRQRELRASNQTPYNRTGMSSPSELVSPTPRGDSRREIETLIDSLVGSSRPSSIGTGPPGSPAPRGSRPNSVLSGGEISNVTSEWTASFTGQGGQATPGPTPVALNLTTVPLTTVYECPPSPVKEVFSYSKGVQTTDDWATPTRTRAQSIASDADEFVTSTPNKRLSRKERDREEELRQKIRQEVEEELRATKERMAEGAAAAQPFSTHNYPIRELTAEELEAVTHSDEFVDFLEQSTKVIERALDQETYDILTDYALHGQDLEDKDEESGNTGGKGAHRVKEVTQFFDDRWSKKRMISGIDFSPKFNELVLASYTKNPTAPHEPDGLVQVWNIHMHNRPEYVFTAQSDILTAKFSPYHPNLIVGGSYSGQVLLWDTRAKSAPVQKTPLTGYGHAHPIYCVDIVGTQNANNIISCSTDGVVCGWSMDVFAQPQELLELKNPSQAKVAVEDVSPTCLSFPQTDPTFFLVGSEEGTIFPCHRYDRAGAKAGVDKKISYKGHAAPVMSVDFHPARGPVDLGDLAISSSLDWSVKLWKIRAPAATSTIGAGDGAISPLIDFVREDVVYDARWSPVKPSVFALVDGAGWLEFWDIAIDTEEPVSRISPSSRQDGRTMLSKSLNKVAWEPNDGKRVATGGIDGSLTVFEVASGLGGKEGLKNEEWANVKKLVNRVEAVGMNGAMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIR7</accession>
    <name>A0A2T4CIR7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DRMBL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1322467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIR7"/>
    <dbReference type="STRING" id="983965.A0A2T4CIR7"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="605"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="768"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="794" mass="87725" checksum="81A2A7212D0B7059" modified="2018-07-18" version="1">MVTSTKASRSSFSKKSAASSNFAKKPAKPNASILNFFQKTAKPEDSLFVGAVPAETVHHDEPHVSDEETRFNEVERPSKKRRVSQEAIQPVPKQETADAAEAPTGDSTIRPVKPAQNGDEPKKPKRHIKTPFIIDPSQTSTDAQFNQLGDFADLDDLGLDEFEGEEMREMRFMREQARLEAEEAGITGDDVDDYLNEQATVEDCPICGGSLLGVSPDEATRHVNSCLDGNPILLPTSHDTAIKEEDAEIKKEATPVEAAEMSKRFARAAVPRPGQANPFEITTEKQPKSAFSKLMSGNAEDSAWATAAATETASRGRPAYERTCPFYKIMPGFSICVDAFRYGAVEGCQAYFLSHFHSDHYIGLTANWRHGPIYCSKVTGSLVKQQLRTAAKWVVELDFEKPYDVPGTDGATVTMMPANHCPGSSLFLFEKPFGNGPNKRVKRILHCGDFRACPQHVRHPLLKADVVDSISGKTKQQRIDICYLDTTYLNPRYSFPPQGDVIQACADMCASMAADSHCADNVWQRSEKSAGTGTMSKYFHSDKPVEDGDQSGPNSSRPKQRLLVICGTYSIGKERICVAIAKALGSKIFASPAKIKICKQLDDPELTALLTSDPVEAQVHMQMLMEIRAETLQDYLDSYRPHFTRIVGFRPSGWNFRPGNGSKAIGANTPPSSISTQQLLHGKGWRTRFSAKDLVAQRGSTREAMCFGVPYSEHSSFRELAMFVMGLRIDKVIPTVNVGSEQSRKRMKGWIDRWMAERRKGGLVRPLVEGEDDEQKDSIPLWEGKAGEGGGAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ35</accession>
    <name>A0A2T4CJ35_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1387945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ35"/>
    <dbReference type="OrthoDB" id="3641178at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="407" mass="46294" checksum="61F919306E76F88C" modified="2018-07-18" version="1">MPGLIPLRMSTLIPASKTTYSISEKSSHTYNHRSWEPTPSRPRTNEENRRTARERPIPAPVAASRPVPSTPSTPSTPEQWKRALGDVKRDFVNRRYRQCSLRCHELLGDMTDSNKPEIACLIYIRFYAASALEMQVRSLQPNSPYRTKLLYQARDHYRIAAHLIREDEAAKRRPSSRSPPSLTSLHTPYGSDASISTVSTRTSSSSLSISSLDSCLKRHNSRPKPKKRVAFCDVPSYEPSPEPSYESSYEPIVRPDSPTLGFDDDWGVHQPSPEPLALYSQPLRSSSGRPQFPLPSPTNSEFSVVQDDDTYYDTPSAADSFLHARSVHHYCTVLSGLQRQIASHLEWLERDITAAENPKNMPVLSEEMRALELQTRIERLRANGWKRQRFDFRKYEALRENALADIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJD8</accession>
    <name>A0A2T4CJD8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1467120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJD8"/>
    <dbReference type="STRING" id="983965.A0A2T4CJD8"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="266" mass="28406" checksum="3AC725CA0DD4A86F" modified="2018-07-18" version="1">MSRKGVGIAAFDRSRLTSRQFASHGSSLRATNAQALETQLAVFRSLLQQFAATHAKDIRSDPSFRAQFARMCSAIGVDPLASSSNSSNSSSKGSGSGNSVWAQLLGRTVNDFYFELAVRIVEVCGATRAENGGLISLSDLRERVSRGRMEGADSISDDDVRRAVETLKPLGSYAVVVVGRREYVRSVPRELSTDQAAVVEAAQVLGWVSVSMLRDNLGWEAARCRTALDDLVAGGMLWVDGQTGGEAEYWNPGVMGDAGHDGDAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJF5</accession>
    <name>A0A2T4CJF5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1396834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJF5"/>
    <dbReference type="STRING" id="983965.A0A2T4CJF5"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="116" mass="13178" checksum="88FF864A7717667B" modified="2018-07-18" version="1">MVSHRVTYRRRNGYNTRSNRTRVIKTPGGDIRLLHIKKRGTAPKCGDCGAKLPGVPALRPREYSQISKPKKTVQRAYGGSRCGGCVRDRIVRAFLIEEQKIVKKVMKEQEASQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJJ3</accession>
    <name>A0A2T4CJJ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1396907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJJ3"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="179" mass="18755" checksum="8AB8B0E1E53D58DF" modified="2018-07-18" version="1">MSQKINAKNLSYNSSLPPFLAALRAQASGATGPDPILAAQRRGAKKRSGSEEAEDAPLVVDEHGNALEDLKVNKDGTVEEAVAAAANAEDDAEAEIKDAKSDAAKKSEAEPARASIGGRKRKVGKVVGEEAQDGAAETAAAGKKPETSKKETDDAEETSNRKPKKKAKKIKLSFDEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJN7</accession>
    <name>A0A2T4CJN7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1435464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJN7"/>
    <dbReference type="STRING" id="983965.A0A2T4CJN7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="492" mass="56186" checksum="23459C549C0D0600" modified="2018-07-18" version="1">MALGRKGAFCFLASRGCLCSGLLYVGYTVIYNLFFHPLRHFPGPKLWAIHYGFYARLELCGDAHKLLIPLHQKYGPVVRVAPDHLVFCHPDALTDLSGHRKAGQLENGKEKARNLLVPNTLFSADRENHARMRKSMANGFSNQAMLDQQPLIMTYVEKLFEKLDEESARGEKIDIATRYNWTTFDIIGDLAFGEPFGCLENSMYHPWVEMVFDGVKNVQVDATFRRMPLLYKLLVMLTPKAMMDAFKQHSELSEHKVRKRLDTVTDRKDFIAAMTSKKGKDVTVQELTANAALLIIAGSETTAVALMAATYYLGRNPGPLKKLCDEVRSSFASEDEIDLVSVGRLNYMLAVLDEAMRLHSPVPGTTPRTINEKGDVIAGHWVPPGTHIDIWYWTMFHYPEFWTQPEDFVPERWLGDPRFANDQKRIFTPFSAGPRVCIGKNLAYAEMRLILARLIWRYDFELLDESIGWDTRSKVYIAWQKGPLYIRLKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJR1</accession>
    <name>A0A2T4CJR1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1322034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJR1"/>
    <dbReference type="STRING" id="983965.A0A2T4CJR1"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="168" mass="19543" checksum="F5C3A74A842EE713" modified="2018-07-18" version="1" fragment="single">RTVYQSTLPYGCIPDGPVDLFHQFLTHAHTQWLELCRRAGECLSQRRFEQLKSQGKSPETINDLAKDAQRLAGLRLSLASQISEARKFIEDNKTMKDDPDGNRQSVLKFLAEDFESGIKTKLDELEQMARDLLQIVSKSVYYLYRRCMLTEYRSLRGVQSARRELRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJS7</accession>
    <name>A0A2T4CJS7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1321875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJS7"/>
    <dbReference type="STRING" id="983965.A0A2T4CJS7"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="395"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="935" mass="104657" checksum="F2AA309EE86E3508" modified="2018-07-18" version="1">MLRHEDYTVGWICGITTEYVAAQSFLDERHDGPDDVSANDNNDYTLGEMGKHNVVIAVMPDGEYGIASAATVARDMLHTFPNVRIGLLVGIGGGAPSKRHDIRLGDVVVSMPSSKASGSVLHYDFSKTMQGHEFEIIGYLNLPPLVLRAASNGLKAKYESDGHKIQELIDRALQKKPRLRKKYMRPNQSSDRLYRSDIVHPLSHDEISCASVCGDDPSILEQRLGREEDDDNPTIHYGLVASADQLLKDAAIRDKLAAEKEILCFETQAAGLMNHFPCLIIRGICDYSDSHGNTAWQGYAAMAAAAYTKDLLSRIPTSRVQAEKKISEILSGVQEGVDKLLHIQDSQREEVKLNWLTPIDYAPIQMDHIARRQSGTGQWFLNSAEYQTWLNGDSQTLFCPGIPGAGKTIITAIVVDDIHTRFHNDTTVGISYLYCDYRRQHTARELLSSLVRQLAQRQASVPDGVSDIYRKYEKQPRGLSLDEIVTLLHSVSKLFSRVFIIVDALDECRADGRTELLAEIFKLQARGGASVFMTARPLPDIVNIFSERDTLDIRAQDEDKSRLFLLAPLHMDALSQEPTIGHIELALKKLPKGLDEMYNKAMTRVESQGGGAGNLAKKILAWVLHAKETLSIRELQHAAAIEPGMSEMDWKFVPSVDVMSTICGGLITIDFQSNAVRLVHYTTQEYLERTQGVWSLHQTNIATACITYLSFSAFNSGYCPTDEALARRLREHPLYFYAAQHWGHHTCQSSPCDESAIEFLRCKAKVEAASQALMAIRVPVAHMYSYPHDYEYFRSYIEDMKGLHLAAYFGLEETVRALVASHDPDAEDSHHRTPLWYAAQNGHKAVTALMLAAKNGRETVVRLLLAVDGVDIYARDWQGETAITLANTYGHKTLAKLLSRTHRSKVKLKDWVKGNDYDKDEIGSRERSLKRPRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJT1</accession>
    <name>A0A2T4CJT1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1435519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJT1"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="796" mass="87881" checksum="D5D8C5DACC455B56" modified="2018-07-18" version="1">MDVYQQHQHQQDSLAAAHNGNAADDDDIEDDGDLDDDMMDRISSSPSIEDALTPRLPLQLPARQTQTFCTRFALPIIIFLRVSMPDETHEAERDRDGDGSCGCGCDNGQDLCAHQAEADTNIDADADADLSLTIPYNKSFEDDDDSDFSLPDDPRFIDYGWAAECLHEPEDIDFEFVYALHTFVATVEGQANATKGDTMVLLDDSNSYWWLVRVVKDSSIGYLPAEHIETPTERLARLNKHRNIDLSASMLTDQQPPKQKSGFSIGIKKKATVVFAEPTYFDYSDHDYSSEEEDADETSEPATARQKKLATSGDDEDATDESARVEPLKPNKSKAAKLSEQIQDDLSDDDEDLRGSLEIVEKRDGPSISRNGNIRNTDSFFKDETTETKKITLTPNLLRDDGPRESTDSMSSKPRTSLDKFEKELMSDKDRKKSKEKDRSPKDKKPGGLRGFFSRKDKKHSPDDRPEGESRDSEERHSEEHSSPEKPRQPAKLHKQQARVEPTVNNKAPQASTVELASYLAESRINDVSNVPPPSMRIVNPETNETQEVPSHQPPRGRPSLETTPPTTRRGPEVAISPRSATAPRALSHLDLSDSDESEDGDAILNQMPQPNSSAPLKTAKAPQDDEDEAPIIPGSFPDSNPSATADKSPVSQPPLAQTGARSHSASPVLPVASSEPPALMVDTSSPDDRSPSASPSPELTQSAEDRSKSSSSSTGSKEQTWDDMKLHAFFNEPDHVRDLLVVVYDKTDVVPASSDHPVVGGLFREQNAKLAEITTQLDNMLGDWLARKQRTRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK57</accession>
    <name>A0A2T4CK57_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1026548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK57"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="168" mass="18177" checksum="5935B3B6192A81D3" modified="2018-07-18" version="1">MGPRLEQGGVEAKRWGGALNRISASRSTGSVAPGPGPGSLVLATTRNSSRLAGGSFVSTEGNQVPLLLWGLARMDRITRPMFPRPEHGRGMGTEYGVTLVKRAWHGAAWWLVSRFRSSLSCPWDVDLSSNQYSPRRQSAVGLRWPMGGVRVSRHHGGRKRDGACSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPB7</accession>
    <name>A0A2T4BPB7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1473747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPB7"/>
    <dbReference type="STRING" id="983965.A0A2T4BPB7"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015529851" evidence="2">
        <location>
            <begin position="28"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="605" mass="63686" checksum="1B35AE08EEB443DB" modified="2018-07-18" version="1">MLSMASLRRLGLGALAAAASLSSLASAHVSVRSLESRQTAADKLVFAHFMIGIVGDRTSASDFDADFAAAKAAGIDAFALNIGTDTYTDQQLEYAYTSAANNGMKVFISFDFNWWSTGDAAGVGAKVKQYAGHPAQLQVDGRPFVSSFAGDGLDANAMKAASGVNPYFVPNFHPGQSSTDGIDGAFSWQAWDTNGNNKAPTPGANVTVAQGDASYKSWLGSGKTYMAPVSPWFFTHYGPEVTYSKNFLFPGGSLWYDRWQEILTGNFNFVEIITWNDYGESHYVSELSSKHGDDGGSKWVNDMDHSGWLTLAKPFIAAFKNGDTDVSKYIEDEHVIYWYRRNLKSLNCDATDTTFNAPANNASGNYFEGIPNGWQTMDDDVYVVTLLKSSASLSVTSGGNSRSFNVPAGATLNTVPAGLGKQSFAVSRNGQNVLSGTSLMDITDVCNCGIYNFNAFVGELPAGPRDVLGHDGLTSLTVGLHVTTCLPQPSLGTNPSVPASQPASPTSAKPSKTSSAAPSDPTNCNGGTVAPGESGNFTGLCSFACSYGYCPVGPCVCTSFGQAPAPPSGDGRDGCPIAGEPSSYSGLCSFTCSHGYCPEGACQYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPB8</accession>
    <name>A0A2T4BPB8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1387264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPB8"/>
    <dbReference type="OrthoDB" id="4666063at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03145">
        <property type="entry name" value="GAT1_cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36175">
        <property type="entry name" value="CYANOPHYCINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36175:SF1">
        <property type="entry name" value="CYANOPHYCINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015482623" evidence="5">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="286" mass="30584" checksum="42A5B1553B4CCE65" modified="2018-07-18" version="1">MARFILQTLLALAAATSALPTDNSTNFVGPENGNLVIVGGGTLDDSILQKVIDLAGGNDSSIVVIPTAQGDPSYDQNAANADDFRRLGSKSVTVLHTYDPEVANTEDFVQPLLNATGVWFGGGRQWRLVDAYAGTLTEQKIRAVLDAGGVIGGSSAGASIQGDFLARGDTQSNNLIIGDHQQGFAYVKNVAIDQHVLVRNRHFDMLNVLKYKPGILGIAINENTAVHVSKNTAEIFGASYAIIYDGTYWSRDGDDANQIPDPSGLFYFLRQGDVYNLGLRKVVHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPW7</accession>
    <name>A0A2T4BPW7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1406566</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPW7"/>
    <dbReference type="STRING" id="983965.A0A2T4BPW7"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26363">
        <property type="entry name" value="Phospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015439712" description="triacylglycerol lipase" evidence="19">
        <location>
            <begin position="32"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB71363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="618" mass="66172" checksum="8A0AF507B7B5D670" modified="2018-07-18" version="1">MVSPSLRCGLPGRVTAALLLASALAISPGSASIIGGDVGLDQHVLLPAGPGPVLPSDPDTVHPAEHTFTLRHIYHHGTDRNPRLHRKLDVVHDQSRVYLAADDEYGEHTVPQLKARSRAETIERLVDRRPSVVDPIVAESRKQGYAAVLDASAWTMDDVSSPDITDKDTVLTMAYVAADAYVENEGQADWQDIGAPFNRSLDFGWGTDGLRGHIWADENNSTVIIGLKGTSPAVFDGEGTTTNDKVNDNLFFSCCCAQQGQWTWHQVCDCATGTYTCNNTCVKTALREENRYYAAARELYSNVTEQYPDSNIWLAGHSLGGAVSSFLALTYGVPAVTFEAVPEALPASRLGLPIPPGADPDAPQSRAYTGTYHFGHTADPVYIGTCNGATATCSFAGYAMESSCHTGYECVYDVVADKGWRVGIGTHKIRSVIQDVILKYDEVPKCARTPECRDCGPWKMYESNGTETTTSAVPTTTSRTRTRTSTCQTPGWWGCLDQPTTTGDTKVPAPTTTTTTTSTCKTPGWFGCKDKTTPASTSPSTTTTTTCETPGRFWGCNDEATLTSSVFTTIPASTTCETPGRFWGCKDAVTPSTRTGAAAAAGRTAPTITSAPTATPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPZ5</accession>
    <name>A0A2T4BPZ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_217707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPZ5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="11500" checksum="5FBCC85672C5C606" modified="2018-07-18" version="1">MRLRLPPQDAVRCQGQHHLRFRSAETDPCLESVHDTICVVNAHDSCSPTSRPLVKPTAHRHEPAPPHFQSSPCLIETCLRHKHHPPKTCLQSLHRSNEPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ97</accession>
    <name>A0A2T4BQ97_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14b/L23e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1406464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ97"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ97"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="14685" checksum="E4A4A1EF2253FC56" modified="2018-07-18" version="1">MAKQSRGAPGGKLKMTLGLPVGAVMNCADNSGARNLYIISVKGIGARLNRLPAGGVGDMVMATVKKGKPELRKKVHPAVIVRQSKPWKRFDGVFLYFEDNAGVIVNPKGEMKGSAITGPVGKEAAELWPRIASNSGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQH6</accession>
    <name>A0A2T4BQH6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1365596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQH6"/>
    <dbReference type="STRING" id="983965.A0A2T4BQH6"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="117" mass="13272" checksum="FD0F97B9A0BBA7E5" modified="2018-07-18" version="1" fragment="single">MGVGNKRTLTKTRRKTRDVDQVISDLRSHKHLKQYKDSKLPEDLPGLGKNYCVACARWFDTPFTLATHERGKPHKRRLKQLRDESKATSKSGQSDALDSDKPETAQYSTDAGVEMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQV9</accession>
    <name>A0A2T4BQV9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1434268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQV9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQV9"/>
    <dbReference type="OrthoDB" id="5355161at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="437" mass="49361" checksum="F59A1EFF4FE5BEB3" modified="2018-07-18" version="1">MQLASSKDANSDANSAHLRPRACIPCTRAKRRCDMNRPSCERCLDKQVACQYSATRPYARRAVKSPRADGPASSRGAESHATPVLDSSLSAFLEAEDCNEDDHGGSAAKDAVAVLDPPFSTVSWFLQVEHWVIYHGDAQPPRLPVIRGSILQQYIRCVRNWLMQWVELGHCPMIHRCLFAETGMPLCVQDAYAALAVYTTKNENNEEMVMQHIQDKADALLESYSVRKDSLVESFVSMSPLSTIEHLSRVLSLFIYVFIRLFDGHIRQRAEAEKLIPLLRDWTAQLWSSVNIDVTIQNAFGGDFLMAKDDTEAVVKLWRIWILMENVRRVWMVSTCTTCIYLVSRDGTGHCDGTIDFTARRGLWDAASAPLWKNMLERQDPLFVAPFQTAWLFERTSVKDIDPFGLTMMSLTLNSDKLDSWIAESTDTQLEALLMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQZ6</accession>
    <name>A0A2T4BQZ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1343633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQZ6"/>
    <dbReference type="STRING" id="983965.A0A2T4BQZ6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="326" mass="35431" checksum="FCDD1ED964F98C4C" modified="2018-07-18" version="1">MGIWTQMCPPKPAFTEQNLGDLTGKVYIVTGSNTGVGKELAQILYSKNATVYVAARSQAKATGAIEDIRKAFPASTGRLEFHSLDLADLEAVANSAKEFIAKETRLDVLFNNAGVMHPPQGSTTKQGHELQLGVNNLGHVLLTELLTSLLAQTVAKNAPNSVRVVWVSSLYSELGSPKGGIDPDNLGFAKQEKSIYYKYSVSKAGVYYQGAEYAKKNKDQGIISLTVNPGNLRSDLQRYGGNGIIQDITKKLILFPPINGAYSELFCGLSPEVTADKSGSYVIPWGRFARIREDIEKGAKSAEEGGNGLGKIWYEWCMEQVAPFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRG6</accession>
    <name>A0A2T4BRG6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1405945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRG6"/>
    <dbReference type="STRING" id="983965.A0A2T4BRG6"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="248" mass="26674" checksum="7A383F26E518B975" modified="2018-07-18" version="1">MSTTTNPDPDASAPAFIPLEANPQLLTALIHKLGVSPALQFHDVYSLTEPELLAFIPRPALALLLVFPVSAVYESQRMAEDSLADEYGGTGEQEPVLWWKQTIRNACGLMGLLHAVSNGPAREFITEGSILDDLIKKSIPLPPAQRSALLEKTPALADAHKAAATEGDTPAPDAQDDVDLHYVCFVKGKDGGLWELDGRRKGPIRRGDLNKDEDVLSEKGLSLGALKFLEREGGDLRFSAVALAGTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS26</accession>
    <name>A0A2T4BS26_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1465841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS26"/>
    <dbReference type="STRING" id="983965.A0A2T4BS26"/>
    <dbReference type="OrthoDB" id="3365636at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="630" mass="70609" checksum="92D840F280063B25" modified="2018-07-18" version="1">MSTASADKTTHGQEAEVRRTASLNRTCEGCRHRKIRCIIDVPPSTTNSPKCARCSKFNLDCVFLPPAIRRRRNKNDTRIKELEQKLQQLQEALAKPPAEVEAGIADLEGSYSADVFESFHPDFQQPSTSSNYSPPPETYIPTALSYATSQDPLSAGNVSPELANDLFTTFCQTLAPEYPLVHLPSDWTWQQTRDAKPALFRAVLTAASSDRDPALFKAMFRNTGLYVTEEASIKGNKSLDLIQALLVLSAWYCPMEDFKKLKFSQYANLAGGMVLDLKSSNDEQYFIPSTMDAFVSSQHLTEMCRTFLACYFLCSSMAFSFRRPSVLRYGSWVDDCIRVLEAAPARLLSDRRLVEWTRLQIIAEECMSAAGLDNESNVCLTDDRIRRVLKYGIERAMSWKQQVSPDIIHEPMIIHYHMVLISLHEPAFYDGHDMQDFRPPYRLRPLPLVKSLENSDSITIANSLAQCVSSAQVVINTFLSIPTNTLRVMPVIVYTRITYAAVTLIKFDVSARMPHSVACMLDDIQLSPKVLLLQLLEKLSEAAGSENLVVPAVFRGALARMTRWYVDQFESFPEPDEGVVFEPMMYVGVDGESSSGLDYGHRGGLGTHEFVVDPNAGFLDALGTHHLDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSH4</accession>
    <name>A0A2T4BSH4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1405623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSH4"/>
    <dbReference type="STRING" id="983965.A0A2T4BSH4"/>
    <dbReference type="OrthoDB" id="4899228at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488:SF2">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33488">
        <property type="entry name" value="ZGC:162509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="780" mass="84276" checksum="CDE941F410083A77" modified="2018-07-18" version="1">MACATVDRLSPAAQDLALQTIDKELRQSSTKEYLDSVKSCMLFRPDFNWSEQLSAAPLSVSILASLFVASTVPDATHITIIPPTGGFKYLENFGGNSALNACLIQCADTGAKAFATSSICFDAISQSSANVKKTVNQIIRLLGDARSAQTLLAPTMQNLSRIAHRCEDRAREMESAFERWLDMVSELHMCVVQTSSNVSEKRRANQVQLAVAQTQLASNEERKRLATDTVSTLNNTLETATSAYKQAADEFPSGWDRIAQQVVSGVSESITGALTLAIPALIEIMSQPAAVAKALNIFSGGNGGAVGGPLGSGEADHSQVQAATDAPPSIPKATIAYPNDPAYSVVKTILPFVSAVHAFVTGGKDQGVDWKALQSKEHGENGLKFLKTFLEKVQKSFKPSSDPPSEELRLVFDKVKTVTEGLGKVLADSTALNGGSPPTADSKEVKEWALSMEEAYAAVVRLDADAKNLAGAGSPPLVNPIQFSKDVHKRGDAFRKQVIDAATIKLETTASVMKTVTEKYDEASKRLVDIQSEIGNIQAELSGLTTANMDLDNIKRILVKCIELLVPLKSHISRLVGFFGAVKTIIDNVVNEKVDNFLDTLKSVTGANDEASILNFSLTDLERQMIFGCSLSIRAYFDLFQDISDMYLNIYNTFIRQGLEMVNEMQIEYNCTTDARVAQMILNQRSQRISAFNESSVNGVRYIIQKRQNEILGNLQNKATEAANSLASIPVKPSPVAIKAIESSSNASMEAAKQGIQNSSPNLARPLSSTNSLIDESEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT06</accession>
    <name>A0A2T4BT06_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT06"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17869" checksum="BB4E2C772AE25755" modified="2018-07-18" version="1">MTESSATQRVMQNHQDTVLQVKSPASQARHNTNPSSTIQETQHPIPRPEAPPIHPLPNSKETTHNKPISLHPPIPYPETPKKQRDKHQHLQTHLTKTHYSTSRLICNTAHDLSSAADRPEPNIKLSKWKTSTPRNHPKLPNTLALRYTKKPSKISPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTT6</accession>
    <name>A0A2T4BTT6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1425337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTT6"/>
    <dbReference type="STRING" id="983965.A0A2T4BTT6"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="208"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="662" mass="75252" checksum="03BF7D1C70BBA965" modified="2018-07-18" version="1">MNNSPGEPHSCALCQARFTLTYGNYYSDNGWYELIDENYYATGEAYIFNIAYHEAVSLADRGCELCAWLVTLRREDTRDESWLRGYFAHNSREVLVLDWVEEVDDWIDGGTLERKVIVCAEESELAAKEVAYRLPNLYPASDETVDMMKKWLKECITTHVECQELHNSNKTVQASDSGPRRLLHLSGSTDAPRVRLEHNAASGASRDYAALSYCWGGDQAVKLKNELVESWTRGIPYEQFPKTIRDAIWMTMALGLEYLWVDALCIIQDSDQDKAEQISCMAEIYERAYVTLSAARATAAPEGFLHSRYIPGEKGFRMPFTCEDGRMSAVVLWQGREPDAWEPIDKHSWCLQESILSPRVLEFGTHNIRLRCGRSRADEAQLRCDGWVGRSKTFAQLGMTQPLMSSIDWKSLGEPYKFVEAWQMLVSHYTRRGLGWYQDKLLAISAIARKMSRMADSSSNNNNKKKRYIAGLWAEHLGEMLLWHPNYGPDAKEKARRHETYVAPSWSWGSLSGEVDFWFGSGMHLLEFVGCEIKTAIQGDEFSAVLGARLELRTLVMRARMRRGGGGWEEGGGRWFLWDEVVGDEVDGSLMLDVEDEDEGGGEFVCEMDEEVVLALVQTQDALVLKRKMGEEEGVYVRIGIYWEGTRGTDPSRWAMEGVVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU00</accession>
    <name>A0A2T4BU00_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1433563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU00"/>
    <dbReference type="OrthoDB" id="4757858at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="48034" checksum="00C68B01CCC619B3" modified="2018-07-18" version="1">MAATNLLALPDELLFMICGQFCHHCTQPGAELRAHGLLRNDAAALRFLSQTCQRLRKIAQSVLHHDARPRQLGLLLRTITARPDLAAQVRVLCDSIQYSSARFENGDLGVIPPGHVTDEEEQTWQEDIRRMQTLLVPTLMRLPAVEDLVVGVSFRRGYMWDTMFDMRSVKRLFLYPYNCRLGFGRLDAFLALTPCVEELTLLNWTGLVMRPLTLSRLTSLKIQGFNLTAESLEALVQLCPILERFEFQQRVIEYEDPPLWMIEEEREPLTWRQMQDILRPRSATLKHLAFGFYPYSNEVGGGLSYNPADDVGSFRDFERLETLRVESLSFRGLRFSDERGLEFYGYPETVSELVGMLPESLTVLRCDHCHAKWDGMELLAQAIRLGHFPRLKTVVSGEWGLKLEASRRMLAAIGVTCKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUK9</accession>
    <name>A0A2T4BUK9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1340054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUK9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUK9"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="186"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="810" mass="91437" checksum="B67062879EA659C1" modified="2018-07-18" version="1">MRYPKNLPRPLISLRSCLRASRRPPASTIRLDRSFFTQSKRQKRQQPTSLPATVLALGLFTWWLYPTEDFARLSESQKSRRRRREDDDEEYDDGDDETDDAESYKLVTEKSDDGAWAYFARQFEFFSSAAELEWAALSDRLVDAIIPEWWKNIPIYVRKLQRELSASPGSLAEEIWQEAHDPVINPEIQYSAAVRVSTELCDEEKEFLSRRKLVTRAALANYLGLDEQDIHPDDVPTIAMCGSGGGMRALIAGTGSMYATDEDGLFDCVTYTAGVSGTCWLQMLYLSSFARGSVSALIQHLKARASTHIAYPPVAFQSLTSLPTSKFLLSGLVEKLKGDPHADFGLVDIYGLLLGARYLIPRGELGVDARDFKLSNQRQYLRHGQRPLPIYTVVRHEIPAEETQDSSDTTVTTVEEMRREPYFQWFELTPYEFFCEEFAAGIPTWALGRRFSNGHDVADHGFHLPEIRTPLLMGIFGSAFCATLSHYYREIRPLIRTITGFQTIDDLVSDRNEDLSKVHPIDPAIIPNFAYQMYGKLPSTTPKSILEGEYIQLMDAGMSNNLPIYPLLRPGRNVDILIAFDASADIKTDNWLSVADGYARQRGIKGWPVGIGWPKDETPEQARKELEEAQAATAAEAERKVEEARAEQEERRKAASDDQKKLDVESKFAPGSEKAGELGYCSVWVGTTEERSTDSPPITKPITDDTTWRLLEPNAGLAVIYLPLLSNEKVPGISPGTTDFLSTWNFVYTPEQIDSVVQLARANYDEGKEQIRATVRAVYERKKQLRQQGETRRLMDKGEADLLDHGDQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUP3</accession>
    <name>A0A2T4BUP3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_139017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUP3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="9985" checksum="3BBBC20EBDD70E02" modified="2018-07-18" version="1">MAFLFFCFLGKGYHLFHPVYYLKSLLLPLFLFLWTHSYLLQLGCLDYLTLVLGTCLVYFFVSGISRWPPWSRKYGIRKCLLPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUR6</accession>
    <name>A0A2T4BUR6_TRILO</name>
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        <submittedName>
            <fullName evidence="8">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1465132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUR6"/>
    <dbReference type="STRING" id="983965.A0A2T4BUR6"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="376" mass="40530" checksum="3EAE2D82C4245418" modified="2018-07-18" version="1">MASKAMWEVDPETRSKLAALQKESKNNVCCDCNAPSPQWASPKFGIFICLTCAGVHRGLGVHISFVRSISMDAFKANEIERMRLGGNEGWRKFFEEHEDTQMRGLTWDDATIAERYSGEVGEEWKERLSAKVEGREYVPGEKRPVTAAAAAAASTSPAKQGSRTSTPLGGSANRSQSPAQQGGKVKVDDRYFARLGADNASRPDDLPPSQGGKYAGFGNTPAPDKSSQGGMLPLFDDVQKDPMGALTKGFGWFASTVTKTAKTVNDGYIQPTAKSIADGEFAKQAQLTAAQLAKQAQLAGKNAQEGFTRFVEGPDSTRRNAPLDASRKDFWDEFSNLAEQQKPNNAIGTSAIGMGKKTTPAAPAPKPKGGDEWDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUU3</accession>
    <name>A0A2T4BUU3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_141515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUU3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="104" mass="11852" checksum="C2586278F5E45DE8" modified="2018-07-18" version="1">MVVSRCESVPLGPLARTKRMASLAVLVACAVLAGKGYMYSRHHLPTHTRPRGSKRNGEAGRGEMQASRPRLWERRRENVAEQTREADTVERKRMGSDKERREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV74</accession>
    <name>A0A2T4BV74_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1404946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV74"/>
    <dbReference type="STRING" id="983965.A0A2T4BV74"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF5">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="159" mass="17283" checksum="717A356DD6BF3167" modified="2018-07-18" version="1">MSRTLVLCFRAVQGLMAAASIALAAYVVNWHLRGPHLSTPLSVSFLLFSAAFTIVSLLYIELAPRFAPKAIHPTASLCVEFANCIFFFAGFIAVAVCLGDLAFCDGSVCMAGRCLAVLAATQFSLWMGSAIFAAKKDRIRGGRRTKWPGLRRGFRDLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVC2</accession>
    <name>A0A2T4BVC2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1075314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVC2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="70" mass="7775" checksum="B939C202F12999A7" modified="2018-07-18" version="1">MTCDRQLLRTSVIINFRWLTVHLLFNLLPIVPTFCACQATASLFDSAATTGLVRYVLAASNLPKSPIRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVJ4</accession>
    <name>A0A2T4BVJ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1446803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVJ4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="90" mass="10549" checksum="A22129D40301CE0A" modified="2018-07-18" version="1">MRKSRRRQFFRPQRAYLRELNGCSYPHSDADVEAAGLPEDRRTGSAAYGAAQQHQRSQRKTHLEPRPKEWEAHFDLVHRRSALFIAADME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWB0</accession>
    <name>A0A2T4BWB0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1394128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWB0"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000012">
        <property type="entry name" value="DUF803 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57460" checksum="057334B4C14E6EE8" modified="2018-07-18" version="1">MPPIGNISPGGSIALGILVGLISTSVQSLGLTLQRKSHILEDEKGPHDVRRPPYRRRRWQVGMAMFVIANILGSTVQISTLPLPVLSTLQAAGLVFNSICATLILSEPFTRWSLCGTLLVSGGAVLIAFFGAIPSPAHELDELLELLARKPFIVWMIIQALFVVTLAVVTDVTSSVSSLSHNARFRLLRGISYGVISGDLSAHSLLFAKSAVELLIKTIGGKNQFLRWQSWTIVLALVSLALCQLYYLHRGLKLVSTSVLYPLVFCVYNIIAILDGLIYFNQMGLISALDACLITLGTVILLTGVLALSWRLSDEQHAPAVGQSSLAPGLGLVDDTEGEEESLIGPEATLEVDEELPSTTYQTFPVMHGEAAPLTPARKKSLSWLERDEIWGELQDQDEPTTPAGRLRSTTFPARTESTPLLPQVRRSMSGVSVTDQPSPSADASPRRFARRRRKSTGFPGLVARRNLRRDSAFSETLGGFFSMNWLRRNNSRPLVSGGLLNEGNPARQSYRDEPEGDSNGRANDPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWG6</accession>
    <name>A0A2T4BWG6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1424914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWG6"/>
    <dbReference type="STRING" id="983965.A0A2T4BWG6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="146" mass="14987" checksum="2C95FED3A08E3C60" modified="2018-07-18" version="1" fragment="single">MQQPPSLAGDRSITGLGDAASRPNLSSSFSPVTSAPSAPTSPPPRPPISLNPPSREPPGVEPVLRITPVPRSVFASVHQPRKSSLVQTPLVSPSPRAAAHPHPHPHPQSHPISHSASGSSGSNGNGSGSGNLLRQTHRDTVHPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWL2</accession>
    <name>A0A2T4BWL2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1424305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWL2"/>
    <dbReference type="STRING" id="983965.A0A2T4BWL2"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="25888" checksum="18134ADA5AEC6CDC" modified="2018-07-18" version="1">MPTTAVRGPELQGAQGVRQIHPQSAMASSNPFLLAADNSPALLPLLREKPALASAQDEHGYSLVHAAASYNHLDLLRTLIEEFKVDVNLKDEDNETALFVVETADAAKALVELGVDVMHRSLEGLTAREKIEGEADFPEVAAYLSTVESAKIGADLEATAAEFNKNAPDGMKVTVGTMDETQDIPAEVDPEFRRRIEELAQREDFDTAEGQADLRKLVEEALSDQGLAEERNVRPKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWV6</accession>
    <name>A0A2T4BWV6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1471837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWV6"/>
    <dbReference type="STRING" id="983965.A0A2T4BWV6"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="282"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="502" mass="58082" checksum="43D5D2CEA10A31A0" modified="2018-07-18" version="1">MSWSSLSTEIQWLILNHLRVSKCRQWAPPSRHRACRLTTGISQAVCASVCRDWSAFFESANFEKLILHQDDIPMLGEVVPRRGALMRWIWLRIELPPYDCPVCNLPESVEEDRVNKFIFTDAIWGLFDILSQLNNDHHPGITLELSAHSPSLIDHYAQELDYMINDTAWHTLDGIGWPRNSSGIRHLLLYGQQRGLTNAAALRMVGHPQGLRFDLRAPVPKRMNKTLPRVRAVKGLVIRGQCYRHFSVAKALDPIIRNLTQLREISYECWKGYDTATLKYRRTLRKISIYEGTSRCHRKLLRPHHTWKSATLGFGSDLAKASRNLEELYVNDLAEADDFFRPFWGNDYLKRATRLMVWRNLRRISLFAELVPPDLHEERIQAAGRAACRMPQLQFMELWYCDGNYQCVFTYDISQHAHDAHKLEMRSSWGARLSPATVQAWRDTVCRRGPGMELEVRGQGEMYILPQGRDLMCASVLRGDALSNTSRRQILGQHRDSYLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWY5</accession>
    <name>A0A2T4BWY5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1052792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWY5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="123" mass="12624" checksum="64A12CDE9E0F0941" modified="2018-07-18" version="1">MGRAATDARAAPNDLIAGTTPTPYSYGHDQETVGTPRPKSGGLVGGEAGISSTLTRLSPQIGAPRNGPANVLPTPQVQAWGKRTSSEWNPGERRLGTAKGASPGVRPKANDREEAGKARGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX27</accession>
    <name>A0A2T4BX27_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1055037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX27"/>
    <dbReference type="STRING" id="983965.A0A2T4BX27"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="116" mass="13760" checksum="8F5614EE539C7D74" modified="2018-07-18" version="1">MFRPRIRNRLLQRYESQLSRQIMTRRGFSTNRSLHKGQGKEADGEALRTAERRAEEARAAEERREYKRRYDGAARRWVSTIIALPILLVTSYYLFDRLVLGKKPKSLEKYRGEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXA6</accession>
    <name>A0A2T4BXA6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1056445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXA6"/>
    <dbReference type="STRING" id="983965.A0A2T4BXA6"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="170" mass="18983" checksum="88C6A918C4BF21AF" modified="2018-07-18" version="1">MLQRSLRLLAFGNHFAVWVSSLIVTGILSFFFVKYNLSHNTHVIYQEVIATITLAVWTFGMVLPLINRYGGHLWIANHILSYLWLTSFIFSAQDWAGGRCTTHAPTFGKCGLKKTVVAFNFLAFFFLLANTFVEGLLFREHRDGRLGSRVPGAHKSRPSTASEGTTSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXD5</accession>
    <name>A0A2T4BXD5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_21429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXD5"/>
    <dbReference type="STRING" id="983965.A0A2T4BXD5"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="425" mass="45570" checksum="47D71EBC19A3181C" modified="2018-07-18" version="1">MFENTCTLPLHADIFTTALHPTEPLLTVGLANGLVETFRLPASNSSDDGADGDSSVLSDGRSTISSVWRTKRHKGSCRCLANSHDGKYQYSAGTDALIKHYDTATGKVISKFGIPTNTSKPDGPTLLHVLNPMSLLLATDTGALHIIDLRDGAPGKKPAQTHYPHSDYVSSITPLPPSEESTSGFPKQWVSTGGTTLAVTDVRRGVLVRSEDQEDELLSSCFVPGLGPKKNRKNGVMVVGSGSGVLTMWDKGAWDDQQERIIVDPAKGGGESIDAIVMVPKELGVGKKVVCGVGDGSLRIVDLVRREVDTTLNLRHDDMEGVVSLGFDSENRLISAGGRTVKIWEELSELQGGDTGSEGEDDSDDDSGDDEKPSGKRPMLDSESDDDSDDGVEEMKQRAKRRREMQQQKLGPMGAHGILGFDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXJ9</accession>
    <name>A0A2T4BXJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1404256</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BXJ9"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="173"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="527"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="93110" checksum="46072F9D8EDE1E56" modified="2018-07-18" version="1">MAAQSNLRRTAAEDALAEFLEKWTTILGKRLRSTSRTTRILGTLSLALSIILGAEGGRRWWKKRRHEREQGRKLVRTNSWLHNKDGSRTIYVPYKDGTSKVVINTTKPLTFEAHRRLFLNPPRVSGLGDGTVPSAQTKPGLNLAFLHQFLSLMSIMIPRWSSKEAGLLISHSVFLMLRTYLSLVVARLDGELVRDLVAGHGKAFLWGIVKWCGLGTFASYTNAMIKFLESKVSIAFRTRLTRYIHDIYLNENLNYYKLSNLDGGVGQGADQFITQDLTLFCASAANLYSSLGKPFVDICVFSFQLYRSLGPIAWVGLMSNYFLTASILRKLSPPFGKLKAVEGRKEGDFRSLHARLIANAEEVAFYGGAEMEKTFLNKEYKSLKSWMEGIYMLKIRYNILEDFILKYSWSAYGYLLASLPVFLPAWGGIGGAAEMNEGSEKGSRERNRMKSFITNKRLMLSLADAGGRMMYSIKDLAELAGYTSRVYTLISTLHRVHANAYYLRSGQSELYSLSDVQGTIQKGFDGVRFEQVPVVAPALWPQGGEELIESLDMIVRRGEHLLISGPNGVGKTAISRILAGLWPVYRGLVSRPKSVGQDGIMFLPQRPYLSPGTLRDQVIYPDGHVDMREKRKSEHDLQKILEAARLGYLPDREGGWDTRKEWKDVLSGGEKQRMQFARLLYHEPQYAIIDEGTSAVSSDVEGLLYETCKERGITLITISTRASLKKYHTFNLQLGVGEQGDGWEFERIGTEREKMQVEKEVQELRERLSQVDELKRRRDEIERELAAVWTDKGEMLEAPSFSYTSSSGVEVDGVQQYEAEEAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXU9</accession>
    <name>A0A2T4BXU9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_109332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXU9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="171" mass="18384" checksum="7AD4AF573FEFD45B" modified="2018-07-18" version="1">MRMSALCPGGWVTTGGMTILKRMQTQAPHAARSSAPSNDRSNERHRRQPAGLLPERGGKSDKIQSGGWEFFPGIAAADPASGGLPPPRGCGRRGHCSARSFVSADHRSRHSFQPVGCRNHILHVDNSVTFGKTLSPLTTADRPRSAVHWLLIQVSQLSSRAPSCHTAASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYG5</accession>
    <name>A0A2T4BYG5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1393444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BYG5"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="237"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1441" mass="156428" checksum="CA3BF37CFB63EC8A" modified="2018-07-18" version="1">MFSPFSQKTQGSSQAFNPFAPRPAGEGASFGSGGAGGSDSQKKNNNKRKDGFASGSDTERRPKVGNPFQVEDGNGSLSDSGIGRQGKKRGGDGEKKKLSSDVKRTQKKERGGAKGLQVQRTVQAATSAEEDSTSRPSSSSSASSVDETPDAAVMRATDPYTKKVYDQLRKDGISPPAWPSQPGDPKSKAEMAKFREKYEDYRQKVRASLTKAALIDDPNKRKTLEDAIAFQGICEDMCSEYEKITRITELDVPQPERDARTGVAKTSRMVKKLARSAAGQEAPLPMDVRSTAALRRTLDYLIDDLLRNDDNLPILHGFLWDRTRAIRRDFTFFSSPTVDDLKTQAYVLETIARFHVTALHLLSQPGKAGEDFVEQQELEQLGKALLSLRDLYDDCNAQGITCENEAEFRAYYVLFHAHDSNTVEMLQRQWRPHFWRDSDDIRTAVSLVEALQNTNDFHPPLKPAPSLAAANAFHSYFRIVEDPSVSYTMACFAECHFPQIRRSILRAVRRAMARPKDTTNDVTAAALNKFLRFDTTQQAIDFAKLHGLDFVPDAQAPMDVDRQLLVLNNRGPLLHPRLHHQYSQNLVEKKRQNRPLPDVIHKTVYENSSDPLPAAPSMKNEGSLFVGGSGPASPAESPFMNSQRPAPLPTFGQPLSGFGSNPAAPEQTTSIFGAPEAPKSTSPFSNPFASAAPPTTTAWGSTPTFGSTTPAAPSNNPPATTNPFASATTPSSTSEKAPTQPTPSIGGAAINPFATAAPAPSIAFQGFQSKAPSQPQFQFPAKQGSLPSSPSPTTVNGTAPSPQINFGNAGGDKPAVSGPFSGIQTPQPSVFSPAAATAQGGTSQPKPSFFASPSPASAPASTSKPTTSAAVGPISAFPGSTVSPGLGVKPSETAQGQVQPSPNDKPSPFSQPSGSITFSSPSSLGNKAPKDGPSIAPSTTSLSGPSLGLEKKSDPEPPVKFPPFSGSLQPSSTSSTGFNFPKPDGLKKVDGSTTTPITSPPPSAAPFAFSVPGPATAAPAPAPAPQPASPPRDALSDFTNWFVNGDNGLMREFEVFMVEDIVRKTYDKFQKDEEERKAREKEERDNAEAKRFRVYNLSLKYFYRWKRNAREKRLRHLRRSGRDQFRAFREAQRAAQIREEQENAQRIAKQQAELAALNRPDELASILRKNQRNKRKAAEEALLASGVLSGVSNERRAVSAIFRNDYRLSPTPSSINGSQGIRSRSGSIASTEGGSKTRALRERLMGERPGRFQRSLPSVSADSSPPEKTRVSKVSERWRLKAMGIVQMPDGTALPESMVDEIKRGLKRDTSLRRDASLRRDASLRRASITSAASARPQSPLALKSYRNDHFADSPLTINNKRKRSFGEEVEGETPKERAEEDTDMDSHKRVMSDADLLIQELRAMRQEMEEGTTWFKSQNGKLQSDILSRGGTPLDEGSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYQ9</accession>
    <name>A0A2T4BYQ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1432476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYQ9"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07566">
        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="776" mass="86877" checksum="BDAE27142873CB82" modified="2018-07-18" version="1">MRIACLQFAPQVADVENNLTKADAILNEADSDDLDLDLLVLPELAFTGYNFKSLGHISPYLEEASTGISSLWARNTALKHDCTVVVGYPEKVDPTLNWPTDPEYYNSAIAVNGDGETVANYRKTHLYYTDETWALEGSHGFFGGRLPGLGQTAMGICMDLNPYKFEAPWNKFEFGQHVLDSGARLVIVSMAWLTNENPQEFTSTPLEPDSMTLLYWVSRLEPLIRANSNQEVIVIFANRCGIEGDATYAGTSTVVGIQSGEIWVYGIMGRGETGLLVVDTDSEPYAKLAYSPLQPKIRSGIDDPPESEASYGNDPSPHKESRDQALDSPDYHYKQSVDQSDVKFRDNKHTWHTESSHRFGGQDDREPPEYPRKPLNDETAESKFARAARESSPKLDIKSLQLDIPPDQYMLRRYLEAESPVPHVATSTFPNHSTTAHPEELRGLQKETDEYVPFYSDILESDKRFSLRSDVSVWNNQPGRVRQLSVSMIDEPELSHIAARERSRTAEVGSGTRPEEHDMTRHKTHSQRQSSDWNSRRGSDYGAPLSRQSSYSQLRRKYSQNQIDELARSYSSSAVLPAYLMQSHTASQVASEETGRGRRRSSHKHLKDARARLGSRGTQMSQRETVDLSQFTLIEEYPSANCPVHGSRPPSGTQHQNHSRARGRSGSHSQHVKDGGTTRRPSTRRDTSQDESQRATNGRAPRRTHSSKPEETLPSNEKKCADKAGATTDSGPKTPTAMLLVPDLELPDGLEKTFSLLKCVEKAPEHIVRRRVSSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYY7</accession>
    <name>A0A2T4BYY7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1028342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYY7"/>
    <dbReference type="OrthoDB" id="2439692at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF2">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015463048" description="DUF7707 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="197" mass="20782" checksum="7A14F9DAECD7AAA6" modified="2018-07-18" version="1">MVSLKSLLVTATMVAVSIAKDYYIDPDSVPLSTRQNWCNSETSTCPIICQQTTNKKTLVNECNPQTLSYGCLCGDNRQPNISEYTLTLPFFICQEYVVQCRNNCGGDNTCASNCAEDNPCGATDPKRYNTTATATQTTAESTSTTAGPDTIFTDTPGGGSSGSSGKGKSMAAPAVEVGRAYGLAVLLGTMFVGFAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ17</accession>
    <name>A0A2T4BZ17_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MBOAT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_56164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ17"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ17"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="607" mass="70646" checksum="02BA9F28B77E543B" modified="2018-07-18" version="1">MGLSSYLRKVYDLDTLDTRFTSSTSVPYQTVIDARDDPAVEREVAARARSSAPPPKWRTPEFFLYYIVFIVVVPYMFWVAYDVSRPSDPRYPKYEKYLSDGWIPGRKIDNSDAQYRTFRDNFPIMTGLLLFHPLLRKGFESVYKPSARGARGSTRLDQRATFDFLFAIVFIVILHGISSFKILAILTINYQLATKLPRKYVPAATWIFNIGTLFANELTMGYRLQLLANWVGPPWGPLAHWGYWLDRWGGILTRWDILFNITILRLISFNLDYYWSIDKRNSNSLEKGLDPASLSERDRISIPAETRDYSFRNYVAYALYAPLYIAGPIITFNDYISQCKYRAASIEWPRTIRYGVRFLLVLLAMELVLHYDYVGAISKAAPVWSDYTAAQLSLLSFFNLHIIWLKLLLPWRMFRLWALVDGIDPPENMVRCVSNNYSTQLFWRAWHRSYNRWLIRYIYIPLGGSSFRNWQSSVKSVVTYLLVFTFVALWHDIKLRLLIWGWLIVIFMVPEWTASYLFPKRKWENRPTEYRMLCCVGAVGNVLMMISANLVGFAVGLDGLRSILSSILHDWSGVFFILTAAICLFVGVQVMFEIREAEKRKGVVMKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ24</accession>
    <name>A0A2T4BZ24_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1423581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ24"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ24"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="179" mass="19456" checksum="A9DAC591420F24A2" modified="2018-07-18" version="1">MSPSSSSNNQAESQVQPAVFLVDILGTQRSLTTFFSLSRMRPETSDPLADPHAKTTVLAPSNVAIEDLPRKPWENPGDYDALGSQAYDGSGGKERADENMMRFVQAHLVVGQDASRPWEAGVKAKTAAGREIWWEEGGNSGGDGEGRRVIMPDRVEVERVASRVANGEVWILKGVLNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ78</accession>
    <name>A0A2T4BZ78_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1030806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BZ78"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF2">
        <property type="entry name" value="MIGRATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
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        <location>
            <begin position="817"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1451" mass="158615" checksum="8883C219B7C0E7D5" modified="2018-07-18" version="1">MSAWTDDEYMNAQAAVSLPPREYVPYRTPSTKSRKSRRSARSITPPGKKKISPTRNGNASKRSSRNIETDEQISILDPRRFTPTLHANLVSEILSLRRDQEEKTKVIESLESALQESREDHDALQESVNATTKENRSLQRQLSLLEGGTSSALGDLSRERDEAVESAAETKKRLDAAQRRIRSQEEDSQRVHEQWAEEKESWENEKRKYERRIHVAESRLQMVLDEVAAYQASHVNGTAQQGQGHGHESDAEESGRDNDARSVRTMSLTSSIRYSMANGPGLSLNSYSLADELKFDDTDDQTDIDGRESVFSSPRQPSPRQHRRAFSRESIISKLHGRTQSIDSMKRPGSVARGRNLMSQSLLEALEGDDEETEGEDSSRALTRTPTNKPSYADAGVQSGSTHAYNNAGVQCSPVPVVEHTYSDAGIQCAAPPAPATDLTPPPTPVPKPLYTDTGIQPIPTPEPSYSDAGIQYYPVCEPSFADAGTQHSITFVPSYADSGVQSCPTPEPAYAETGVQFSPPSSPTLDAIKPEAEALGAEAAPRSPERDESVHLPPALERPATPQRMVSSASQTVGVPMTPPKTPNSLFTLPSGSPAEVKASTAGPKMVTSSTQTEAPVPAPAVPPMPLPPLDIPSISIQPPTSRPASPHSPKLPQHFKDFGCQVNIVDKDGMVDSCSQTEAIQIDKRLARLPTHLQPSSITSRPTSPHTSGIAVPDKSDVPLPGSLPPRNPRRLESSRYSTDLPSSPISIAMDEPDLHDFNDDLLLSGQRAPIIPPRRFSSLFSGFCTDSDEIDEFGDLDLSDSEYRTALTAPRPPSNLSRTGKRSSFGTVTTSPDQPSKRSGRTSARSVRSGDLYSVGEDERPSRITELSPAPALSPSIRNSDMRKATMAQTGMVSYPTIVEPKNPPPFPIPARASSRKPSISASIPSDGRSTPSTTSWHRHRRSGSRTYANNVRRVRSANTLQRHERHQRTGSRTPPLSPSTEAPESPSLPPLPQNAITTPRNREGGSYRKHRHQLSNNTVMTAKSEAVSQASSQTPGVVDAIAQTMVGEWMYKYVRRRKSFSVGEGAHKDENSNDRHKRWVWVAPYERAILWSSKQPSSGSALLGKTGRKFAIQSVLDVKDDNPAPRGVTTPIFNRSILILTPQRALKFTAPTAERHYLWLTALSFLAHSYQAVPDVLPAPAQQHLSVKQQPLPNFEPPRPTKLTRGGIRDSIRLAKGRAVAPKPDLSTMPSIPDVPPVRMGDVARFRVAESVTGPGHAREDSVDAAVPPMIPRFSDKKGRGAPNHGRKRSNTGGRVPPPLSFRGFAGPTLGESDHHYANSTAGASIDTSGSSDIYQSQGSTAASWGAAQTPLTTASSQQGNFFDAIGTVRMEAFISPHAYQEYNEYQGGEDYKSLARKKSKEFRRRNSRHRRRAQLSRSTRASDEFFSGSKTAGEEDFFRDDPFKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0X5</accession>
    <name>A0A2T4C0X5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1271414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0X5"/>
    <dbReference type="STRING" id="983965.A0A2T4C0X5"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="22772" checksum="B65EE7C4388262E6" modified="2018-07-18" version="1">MEAQVGCGPWNSNRSSMLVDQQANPVPKAEGYESLDKTLSDVQGAEPRVPVPPSHQAAGKLKRHHSLPYQQPRSVDNLIGAARNGPVSSRTRRAQAAQGVQQYEAPAEEDELLDEVLTSTQRAMKRLEGNANSLRQSASNLGLSTSQPYPSPSPSANSNQLLYADGAEALAPKPLDLSKKTANQYKWPTPPYEGGEWSASASASIWAAGNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C115</accession>
    <name>A0A2T4C115_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1423278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C115"/>
    <dbReference type="STRING" id="983965.A0A2T4C115"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="376" mass="42290" checksum="B7A09140C0320C2B" modified="2018-07-18" version="1">MAPGRYALRANELASMLSGSTLTIPNLKVPLANFARGQSKYTAEIRRWVDRLVEENIRDRRKCIGVKRCDFGFLAACCFPDSDWEQLTAAAAFLVWIFTWDDIIDHGEDTSGIISNGDRARVFCQQSLEYISQKLGLDDGSYGEVAGQIAPSMSMFDETAGPLMSANWSQRQMRRLYSEIEHYVECCLVEHLQQEDDSIPTQEEFTNMRFGTSGITPGIAICEFTRNISLPDEIVESAPMKVIWREITRLCMMINDIYSCQKELRSGVIQNIIPVIAYASGTDDITTVTQEFMDIFQRSVNTFEESFQLLKALASPDPKLSEDIQKYIENCQTITTGLLEWMLRSERYGVCKYLQADGSALVPLVYDSGKAAAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C162</accession>
    <name>A0A2T4C162_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C162"/>
    <dbReference type="OrthoDB" id="4876535at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015672764" description="Cell wall protein PhiA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22967" checksum="E551C6BBCC737BED" modified="2018-07-18" version="1">MSYKLMAAMLALTSGISQVTGQICAQNIVTTHAGLTFYLYDDSIPENNYRPLQLRPSSDGQFSYLAIDNSSPPLLANLDNGVLVSEGQASDGTIFDLGPKGFLQNYTTIPLTVPTTVGQLAFANTSSFPNASDSNWFLSGASGTNTYNLWRNEPVNTLNGVQICEADFDLNEDGTPWYYFQYVDWVSYYPPNCEFVAVLTNVSSSDQPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C167</accession>
    <name>A0A2T4C167_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1379333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C167"/>
    <dbReference type="OrthoDB" id="4825202at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015563718" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="12368" checksum="1E94DF3DF889290A" modified="2018-07-18" version="1">MRAAVVLAALTSLVAAAPQIQISTGEIGLIFTFTNGSQSGQQWIADSASPVPLNSGGIVDNVFVQPLENPAVPGHYHGASCSFLDFQSRDLGVGHVSSPGIIRLESKDVIEYVQCKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1G0</accession>
    <name>A0A2T4C1G0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1402921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1G0"/>
    <dbReference type="STRING" id="983965.A0A2T4C1G0"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31766" checksum="C8D00652167CFCF0" modified="2018-07-18" version="1">MTSLLAKMISKRILGESLQNKFGKEDPYFEQVPATRLDGRPTGKVKKRKKALPPGISEHDGQVLTKVKRRAYRLDMSLFNFLGIRFGWSSVIGLVPAAGDMLDAFMALMVYRTCCQVEGGLPSAIRIRMLINIILDFAVGLVPFLGDLADALFRANTRNAALLEQHLREKGKKELRKSGQPIPAVDPSSPEEFDRIMREDPPEYSSTPPSRRESPIRPDDRRYAQDPRAPREPDAARVRDGGGYLGRNKARPHDVEMGHAHAERYNDPRQNTKQSRRFGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1I5</accession>
    <name>A0A2T4C1I5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1431904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1I5"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015492347" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="16584" checksum="1D9DAB97C51D0C75" modified="2018-07-18" version="1">MKLSLTLSTLALALTASASPISETKSAENKAAAAAAAAAISGSGTPGSIFMFGSAANCRQIFYDFGACGLSTFFADEVPASMPLVAIPSGIFDRFGEAQDNSLCAKVITMTHNGVTRQAIVADENTSSEQSIDMCLDLWQAFGGHDGDGSLITNFSWSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1M5</accession>
    <name>A0A2T4C1M5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1423505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1M5"/>
    <dbReference type="STRING" id="983965.A0A2T4C1M5"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="995" mass="109818" checksum="08F5737B9B25C3A9" modified="2018-07-18" version="1">MQDELLPSEVEQVESLILSLYEPASPSTIAKTQSTLSRLQSSPQAWTLAHHLLGRPDDKVKFFGALTIIVKLNTENASLSDADAIELLVSLLGWYMGSLQQKTGLLVVRKLSSALSTYFVYFHRLCSRFVFHLLVCLASNRAWQPGAIDDTVDFNAISERLSGVHLHAAILVISNILEDVTRIDLNAPSNVGLYDSVLANTSDSVTLIAMCMSREDASSEVKQDALRCLQSWVSFAQKTSARNSYIADSLRPLIGGSVNALMVEDLYSVAAELLVDVLFNWPSLLTEQHYTMLSNIFDTPWFQNRYDLLIQGDFDFESTQLGYVLLAYGEARMQSLIQDENDQSRSILSRLCGLLTADGYPVADDKIFVPAIEFWSTFTETVSDMDVESTFTVSFIFEATSHAWKKIIYPPAEEFHSWDSGDRVGFNDARKDVVDFLQAVYVLIGPKLVETFSSLILTTLSNSAWLELEAAIFCLGGLADCSREDARCDGSLAAVFSSPLFSVLQSGQEHVPARVRQTCLTLIEQYTEYFERNTHLLPTALGLLFNEVPNHSMAIPASKSIHRLCSSCRSHLYPEIDNLLSEYRKLAATASLDCISREKIIGALAAIAQAIPGDDERYDACSRLIAFVQGDVRKSMELANVANDGVLPPQMESPCTDIAPDEHVGLHIGLRALRCLASMGKGLQSPPDLAIDLDAVSPQKAQTPKLVELQKQVIGIIVEVQNVFNGSSEVTELICSVLRSGFSESEPGPFVLTPEDIVGFLVGHSKDTPRIGVIVSMACSFVSSLSPHRLGQYRKILSDVLGWVIGLLKQLPEPGAEPELVQNGIDLVSRLLTRSPATFIGLEPSDAIEFFFLFTLQVLDGKEPLPKAAAAEFWTAFVGTRPDEPELQETFKRAMDMLGPLLAQSLARNIGGNALRSELDRLCEPLRKLVSRYPMAKEWLQSGLDHPSFPSQKVDAEQKSLFVKKIISLRGSRMTNQVVREFWLSARGANFAYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Z1</accession>
    <name>A0A2T4C1Z1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1334702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Z1"/>
    <dbReference type="STRING" id="983965.A0A2T4C1Z1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="494" mass="53783" checksum="41D859F51E66BCAD" modified="2018-07-18" version="1">MAAAHEIENATPPASSTTSDDETLPSGTTSQPTFNDPKDPENPKNWSLFRRLFITFIWIAGNLVASVSSSIFSSGAQAISEEFHVGTEVVTLGVSLFVIGYSVGPTFWSPLSEQFGRRYPMLAGMALFTIFCIPVAVGKSLTTILVGRFLCGVTGVAPIALFGGGLVDIWHPEQRAIAMATVIGIVLGGPLLAPVMGSFITASHLGWRWTGWLSCIMGGSCTILVFFGLPETYPPIILQKRQDQSEKRKTGGWHRFVRVYLVRPFVLLGTEPILVLMTLYQAFAYGILYLVFSSYPIIFREQRHWKLGLSSLPFLGMMVGVFIGSAMIVTRIVLLQRASRRKQSKEAQSQTLSTNPPIPAPPERRLPLMMAGSILLPVGLFIFGWTSAPDIPWVGMIVGSLFVGSGLLCVFVTAMTYILDVYSHVANSALGANTIVRSLFAAGFPLFASYMYKGLGVAWASSVLGFVSIAMIPIPVIFYKYGPRIRALSKTLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2A5</accession>
    <name>A0A2T4C2A5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate/L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1402161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2A5"/>
    <dbReference type="STRING" id="983965.A0A2T4C2A5"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="38237" checksum="6027E8E58819C7BA" modified="2018-07-18" version="1">MSEESEPKINVPADEARRLVQDILKGNGVSPDHAAIIARCLVAADLRGVDTHGMNRIPSYMERIRQGVLNPGAQPELKQVTPVVAQVDGRNGFGFVAAHMGMQAAIEAAKVYGIGMTSVKHSNHFGMSAWVVQQALDADMMSLVFTNSSPALPAWGGREKLMGVSPIACGAPGRGEMESFILDMAPSVAARGKIYKAKRRGEKIPLDWALDGEGRPTDDPEAALGGVMLPMGGPKGSALAIMMDVFSGVLSGSAFAGHVTNPYDASRPADVGHFLVAVKPDLFMDLEEFRARMEYLYRRVVGSERAAGVDRIYFPGEIEQLTQRERERSGIPLVRAEVDALNEEARRVGAAELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2B7</accession>
    <name>A0A2T4C2B7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic AMP phosphodiesterase, class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1334775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2B7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2B7"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="521" mass="56090" checksum="BFF31AEDFEDA6D19" modified="2018-07-18" version="1">MTETVSSPALQVIILGSGGGPQESNTTAFLVRSVPLNWRKGSIVAVDGGVHLSAITRLIEEALPESPPPTPTPSSVPARQILTSGPFAGLELPFTTAAANAAYVTRTLVDTYLITHPHLDHISAFVINTAGLPGTRPKKLAGLPGTIKALKDHIFNNVIWPNLSDENNGAGLLTYLRLVEGGSPALGEGYLEVCDGLLVKTWSVSHGHCMEKHTHRGSFCNPAPTRHGSRHGSQDGSSIPLRRDTYYPHSLMPQAALGIASPALGPGDFEPRPCVNDSSAYFIREETYEREVLIFGDVEPDSLSLSPRNLMIWQEAAPKIASGKLAAIFVECSYTDAQPDERLFGHLKPAYLIEEMQVLASEVEIARKARSLETKKRKRDAEEEQEMQRKKAPVVGMQSPGSEDPVSPKSANPLNGDYFFNSASDTETPHIATPTGELSLDEFAAPGPGLPPPTPAVTTEADSGVKKPLEGLKVVIIHVKETLADGPQAGDSILQQLLEHEREAQLGCEFIISKPGQSFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2G0</accession>
    <name>A0A2T4C2G0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Filamentation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1431408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2G0"/>
    <dbReference type="STRING" id="983965.A0A2T4C2G0"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1177" mass="129877" checksum="120EEA9E6D0B4C2A" modified="2018-07-18" version="1">MATKAARYVESLDDARCEGNWPDVPELVRKVRKHDPARECLTLTAETECAISKVTAAGTQPSDLDVPNRLPKLMAAIESESRPEERFQAQVCVGWLHWVVGEYSLALERLPKSLTAEIPDIDPANTASEWTIVCALKAAYLRANCLMRDGLRLPALAALQEGLPSLDRVWSGHGIRKQLRYWSELFLTEHCMLTSEALHNNEILLDDPNSISSFRSWARYWKTMSAPVAGGFGFKGSVPRRRIWHEYYLALSRILENDLPYPTGQAEKMVDDMSARSQLRVELQRAESAYQALLLGETTFPRADEDRAEVETFVKQVMMNWSILCGRGWSEQDLGQGGRDLLSRSVLDTLYSAATRTYHSTAILRSLFTVHLSVAEFDLAFKALDSYLDIVKRGKARVAKTGHPEPSLDDDKTALETLSQGVMVLCTYGHLQAAEKARQLGAELEDWLSKLPHVNAQENGTPVIVEDKEESQVQPDAPPPQTVALAWQAIGLAHAHWSRVTTEAGSRAEIQSKAIRCLRRSLAPEYGRSKDVRSFFALGLLLAERRELATAIELVRSALMAVHGFEEDYNLFYGPYWQERSLIPLWHLLALLLSARQDYTMAARACEGALEQFKDPTVLFGKADGGFRSEHLNDAEKAAPPRGLVDDMSDEEKVGILDVKMTQLALVELMDGPDVAVNASYELLTLFSRLFGSIDVQQPALKPPVVREPPKTSRTFKGSIFGSRADRSRPPTKQMSNATLGEKTATPDRPATSHTTAPSIAPTVQVTAENGNRRSRSGSLGAQTQRSESGRRNSLKKKTRGGSQRRRSSSLGGLSHQATVIGDDSTDHDFFSTAGRRLQSRVANSSRGRTRSSMNSYLSTNSKYADDDLSGDVSFTLPHLLPLIKFPKDKERNQRTAILIKVWLMIAGFYRRAGMLEDCKGAVAEAQKLIQTLEGEVAKDPSSGPGTSRVPSWGEKKSVDELWGDIYSELGFLALAKETPYAARTEFESALSYYPDHPAAIVGLSNILLDIYSEKLLPTPSIPPLDGHEIYDDAGQAQFESSSAALKTLPFTPLGLVSDPGPTEADPGDGDEKDAAKAAGSGSESQDEDALPQPYKAFHLPLIDRLAARDRAFTLLSGLTRLGTGWDYSDAWFALARAHEESGQVDKAREVLWWCVELEEAMGVRGWRSLAGGGYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2T8</accession>
    <name>A0A2T4C2T8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1262029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2T8"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="224" mass="24866" checksum="AC789810179A7739" modified="2018-07-18" version="1">MPSLTLLRRSVDETPRPHFDVARSLSQIANKIRPAGQIGPLKVFARGDDSDGSSDAMINALLIVLGIAFAILILVSILLVLRRVRRKRGLDEQEPVLPSYDDVKSGHPNHRGLTIETTHNGRSSVLFIGRDGQPMLRAPTSPPHSPDNVPEIHITFPDEQDEQGRRKSGRVLVVRVGENATVGLEPMHDEELPAYEKEANGQFYSVDMDKIGGLKEKDHSYFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C303</accession>
    <name>A0A2T4C303_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="8" type="ORF">M440DRAFT_20140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C303"/>
    <dbReference type="STRING" id="983965.A0A2T4C303"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="503" mass="54299" checksum="3001DFB08486A3A4" modified="2018-07-18" version="1">MREFMDYVHSAFYEATGWRRDNSYAALNSTTDALLNFRTPRGLRLTLSALASPNFATSYQLGSVGVVDGSISYLFSSVPLRLLLTPQSENVPLPDLLRSYRPLTPVARRDDPSLRRPDDEDKTNESLLYGRLYLPRSQLEALLVRRLSPALQAQFSAVSGQHLRDGGTALGLLQYDVGRYALEGLASTDGGLLGFRGVYNFGGDLSSKKHTAASTAENGNGGGNSDKERIYGRFSTGGEIYYGTLNKSGGISIGARFATLPDHKGTPLSATLTLNPLMGNIAASYAVMAGKDCSLATRMEFNIFSYESSWAVGMELWRKPFARLAVDGEDSEADIPATTSISKATSSSISKASTSRTDGSAPVTKTINAVPVLTSVATPAERSFNAKLEWRLDEPEKATEKKTGSKTNGSSVGKSKGGKKGSVKGQAFQKGDKAEAEADKEADKEKEQEYAGVVKARLDQNLRLGVLWEGRVKSLLFSLGSGIDLKMMNKPFRTLGLEVQFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3I1</accession>
    <name>A0A2T4C3I1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_31703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3I1"/>
    <dbReference type="OrthoDB" id="5415072at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="115" mass="11520" checksum="BAB4F2D6D8A342E0" modified="2018-07-18" version="1" fragment="single">MGNICGKSESEPDARAGRRLGSAPPQGPKTAPVPRKVGGPARTLGSGGSGGDSGSDPGDVRRKAAEAAEARAKASSKGGKLQSQLNAQKKQNRSSALAEASNQELLAREADAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Q3</accession>
    <name>A0A2T4C3Q3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Q3"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="129"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="403" mass="41817" checksum="D5122BF0A3AA644E" modified="2018-07-18" version="1">MNSSTLLPISSLINPFLTSTTSLPLNTTILQNPIIAPSTGGLSTCISGTIPIPLNTTGLNIPLSPPPDQPALTQSLVNLLASDPSWLNNILSNSTPTLISGTHDIFIKLCLPSNPPPSSSSSPIKTVQLLTHGATLDHNYWDISPSHSYVDAASSAGHATLSYDTLGVGKSAHPDPIQTAQASSQLAIAHHLASLLRHSHLAGFSFENVVGVGHSAGSTLTQAITTQYPSDFNAVILSGTTASAASVGLALAAFNLINANTDPAAPQFGDLPAGYLTQQSAAGIQFAFYRYPNYDEDAFERQVAGKQTNTLGVLLTLGGLVAPSTSFTGPVMIVNGQHDVVFCGGNCLYPTDQNVVALETFYPAAAKGSRTYIAEGAGHSIAAHGSGPDSFKAMIDFLQENGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3V5</accession>
    <name>A0A2T4C3V5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1457068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3V5"/>
    <dbReference type="STRING" id="983965.A0A2T4C3V5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="353" mass="40167" checksum="0FFED7F69ABE223E" modified="2018-07-18" version="1">MNMASQNDSSTSEFALIKREGEDAWTAIKKTDPDETDLYIALPWSHFKVPTSNDPYEDEPEEGLVTRLEAPSWSHVNKLVLKNVEAVSRIFNHKNIVSIAGSIQADSSEAAASTSADLESTGYMVWDYCAHADLCARLEAARESPDKTIRESLCWHVLTLLLEAITYLHDGKRLVVEGGQRRWKAEMSTWTPILHGKIEPHNVRFQQKRHGEEHGRCKLADFRWAVAMNHKISYGDEADELDEDGGDAASRLQRLRETLLSSTCVAKWPSPHKHSIDSELCSLGRLMYAMMADEGREKEAYKAYSEQLRAVVSFLLERKEFATRFSQCRVERVLPTTKVVMEYFREWKRVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4B8</accession>
    <name>A0A2T4C4B8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1356373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4B8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4B8"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="14673" checksum="AC09A34560E53156" modified="2018-07-18" version="1" fragment="single">MPRKFITQEVKDQNRESQRRSRARRLELINDLKNQVQEYQRRGASASVEMQRLAQAVTHENQRLRSLLSERGVSQEEVQRYLSSSPAPQLKASDASYLFEPGSLRCEACGSTSIVRETQAATMTGTRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4E8</accession>
    <name>A0A2T4C4E8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSCRP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4E8"/>
    <dbReference type="OrthoDB" id="4884341at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015587704" description="SSCRP protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="14712" checksum="A7A0E95126BE081A" modified="2018-07-18" version="1">MKAPAAIALLASFLGTTTAQQTTPLGSVTFNAPQCGGGKNNHIDAADCNTAVPQLLSAHCTNGVCSIPPATQGAQESAISVTVGHCEVFIGAFANGNAVTFDEQSVQDAFPNFISGCLATSGGFGSPLLISTDGVLRLVISNGESGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5A3</accession>
    <name>A0A2T4C5A3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1690-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5A3"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="18122" checksum="E52A6A809B409CEA" modified="2018-07-18" version="1">MGAQESKPQGHTWKISGPPSVSLPVLETLQTSPETDASRAKLDEIHIQARVAEELKRLEKQQSEALKFAHEKIAEAASSAAEDKGPSRYTVGKEIEELRTKLEQRKKVKELPESVDAARNSVIRCLRENDRKPLVCYDEVEAFKAEVKKMEREWINRITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5E4</accession>
    <name>A0A2T4C5E4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_302900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5E4"/>
    <dbReference type="STRING" id="983965.A0A2T4C5E4"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="35213" checksum="3A6E559CBECD6453" modified="2018-07-18" version="1">MAFTMHSHSGQFCPGHAVDQLEDIVLHAISLGYKTMGLTEHMPRYEERDLYPEELSDPQTSLQTLPHLHTSYLLEARRLQLQYAPQIHILIAFEAEFIRPSYTSHVLSLFTSSPLIDYFIGSVHHVHGIPIDYDRPIYAAAVAATSNGSEEQLFEDYYDLQYDMLKALKPRIVGHFDLIRLMSEDPARDPRLWPAVWEKICRNLEYAASIGAWLECNTAALRKGLDEPYPGRIISEKWLQLGGKFTMSDDSHGIAQVATNYARGLTFLESLGVEHVWTFARQDHPEAGEAARATLDDVAVSLKEFRQHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Q6</accession>
    <name>A0A2T4C5Q6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1421945</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Q6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Q6"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="299" mass="32048" checksum="4AA71F727227419A" modified="2018-07-18" version="1">MDNSNIYRRRGFQSGNILGDPFALATTSIAFLAWLITIVGCVIGQIQETTEDPFPKFAWWASIYSFFLIIGIFYVVGSDTIQTYHVAITGYTAGGMVLVTSSVNSLVYSKSGAREAAAAGFILLSMVVIVWTLYFGSTPSATPRAFLDSFALTKESATMGRQTMSNFGGGMGRPETSNSVQPPQMYTSAQLNGFENPSPVGGASQVGGGRGSHVPGFGGNTGPAQIKVTGPDAEVVPPTEYPYRAKAIYSYEANPDDANEISFAKHEILEVSDVSGRWWQARKETGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5R5</accession>
    <name>A0A2T4C5R5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1430641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5R5"/>
    <dbReference type="STRING" id="983965.A0A2T4C5R5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="584" mass="65248" checksum="2476F805FB1E3343" modified="2018-07-18" version="1">MAFMNAFHAIPAFGFAFACLGLAKLLYSHLKTFELLDIFWWAQLMFLGLSTALLGRCVYILAFHPLAKYPGPLIAALTDWYTVYWIAEGGRHLELDKQHKRYGKHVRFGPNRLSINSAQASKDLHDVRKKTNKADAYASFKRFFGAEMSLTTVDHKEHTFRRAVNQAAITPAAVKEFEDQVTPHVDEFINIIAEGAGSKAQGEKGWSFGKDMSYAVAFCLADIMGSVTFGRTWNAQKDPQYRHFIKDLPNGVAGIHLVGHMQSLFFGNLHKLLFKELITGVDNLMKVSRSFAMWRLEQESMPNRDVWAALIAARDPKTGRKFTTEELISEASLFIIGGTDGMITSTTATLFYLTHNPRTLERVTREIREAYPLRAEDIGKKGLAVHCPIRFASAELQAIEYLTACIDEAMRLSPPVASILPREVGPGGLVVDGEYFPPGVNLGIPHYSMHHSGDNFAEPLRYAPERWMPEERKRGAVDGSVPVSGREPATMKAAAGHTDGFTPFGAGRSSCIGKYLAYQEMSIVLARMLWLFDIRLDPGSNLGEGVGDDLEGRGCRNEFQLYDRFVSSQKGPMLQFRYREELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C616</accession>
    <name>A0A2T4C616_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1401367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C616"/>
    <dbReference type="STRING" id="983965.A0A2T4C616"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="303" mass="33452" checksum="5FDA814CD78F02C8" modified="2018-07-18" version="1">MASSYGSHAPTRKLKDSCDLCSASKLRCNKQKPTCARCASLNQPCSYSPARRAGRPHRVREKSQQQCLEMSVDRAMESTGDDSKSREMSLDTTFLCMQTLRHDQSHQQQRQQQRQQQQQAAERPSCQTPYQDAGGGDCARIAITILEQLDVARRRANHTSVSSATTDACQRLLTILVCPCSEQPGVALLVACGCISLMDTVHHCHVLQSAPSQETMTRTTPSPSPEKDLSAWHRPSSSNNNGQGVEQLAKIAKVILQFTDRYSQEPKGGGAWTQTTWLVAPIAALLRFRLQTVTHQAAKSLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Y5</accession>
    <name>A0A2T4C6Y5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Y5"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Y5"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="128" mass="13673" checksum="BF8B2ADA76FA9B07" modified="2018-07-18" version="1">MSGKEAVLTSNAPKPLPGIYSQAIKANGMVFVSGAVPMDPVTMQLIDGDIQAHTHQCIKNLSAILEAAGSSLEKVVKVNVFLADMGDFAKMNEVYSTYWGDVKPCRTCVAVKTLPLNTDVEIECTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C736</accession>
    <name>A0A2T4C736_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1437894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C736"/>
    <dbReference type="STRING" id="983965.A0A2T4C736"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="554" mass="60525" checksum="B1231D6E9F55FBF7" modified="2018-07-18" version="1">MADVHIADAPEGRKQSIGIHTTQDVEHIEAPITWKAYLMCAFASFGGIFFGYDSGYINGVNGSAIFYKAVEGINATKLSDSHTSLITSILSCGTFFGALIAGDVSDWIGRKWTVIIGCAIYMLGVVVQMITAPNHALGPIVAGRLIAGLGVGFESAIVILYMSEICPRKVRGALVAGYQFCITIGILLASCVVYGTKDFTNTGAYRIPIAIQFPWALILGGGLLFLPDSPRYFVKKGEIQKAIDALSRVRGQPEDSEYVQNELAEIIANEEYERALIPSTTWFGSWANCFKGSLWTGKSNLRRTILGTSLQMMQQWTGVNFIFYYSTPFLQSTGAIKNSFLISLIFSLVNVCSTPLSFWTVERFGRRTILIMGALGMLICQFLVAIIGVTVGFNKTHPDPSNPDAVLADNIPAVNAQIAFIAIFIFFFASTWGPGAWIVIGEIFPLPIRSRGVALSTASNWLWNTIISVITPYMVGTDKGNLKSSVFFIWGGLCTCAFVYSYFLIPETKGLSLEQVDKMMEESSPRTSAKWKPTTTFAAQMGTGEYIEKPTAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C763</accession>
    <name>A0A2T4C763_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1400325</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C763"/>
    <dbReference type="STRING" id="983965.A0A2T4C763"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB77406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="14925" checksum="1D5E1C8A0D017E41" modified="2018-07-18" version="1">MASRVFASRLASQMATKAARPAIRAPVAAAKRTITTGSPMQAMKRQTIQAAGRNAFQAQRRAYSSEIAQAMVEVSKNLGMGSSAIGLTGAGVGIGVVFAALINGVARNPALRGQLFSYAILGFAFVEAIALFDLMIALMAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7B3</accession>
    <name>A0A2T4C7B3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7B3"/>
    <dbReference type="STRING" id="983965.A0A2T4C7B3"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015710218" evidence="1">
        <location>
            <begin position="20"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="381" mass="41243" checksum="A43563B3CCB8E8E4" modified="2018-07-18" version="1">MRLITTTTLLASLLGRAYAASSADGVSPAASEVAAIRTFFYTGGGYADDGAGGHIYREQMYVERLQPAAGVSKPTPIVFIHGQAQTGTNFLNKPDGSRGWASLFLDQGYEIYIVDQTLRARSPWQPGYMAALPSTYSAEIIEQRFTAVQNYNLWPQAALHTQWPGNGSMGDPVFDTFYSSNVQFINNAAYQQTTVQNAGAALLDKIGKPVILVGHSQGGIMPIVIADARPKLTKALVLLEPTGPPFREAIFSTTPARAWGLADIKLTYTPPVNVPSVDLVQQVYPAPDANHTDCVLQASSPAPKQLTNLASKPILLVTSESSYHAPYDYCTVNYLKQAGCSLTTHLELAKAGFHGNGHLFFMEKNSDQIQQTIQSWIAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7I5</accession>
    <name>A0A2T4C7I5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_281548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7I5"/>
    <dbReference type="STRING" id="983965.A0A2T4C7I5"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1012" mass="115812" checksum="5C2D9CD63B203893" modified="2018-07-18" version="1">MLKNATRELEQRRPAPRQLFHASLMLSGTLLQRCSRRTLASQAAVAIGREGGRVGRLDQDDRIFEAQPPRELPRVAAKVGLYRHIAQPPSHGVEKKSSVRYNWQKHVLARHRQQRNSPSGTAVSDTAKTSPTSSNQPLTPRRRKPMYTSMALKAWRDVSPNVLLQKALDANDDSRDWKIQAARSRIPRLPVILLQMMIRKEASEEAGQSELLELLPSTEKWELMLDNARRRGYSQDDLEHYLYIFEGKTDDMRCERFLERDSHKPPFMLHLLLRQTSRISRLETLNRLVGYCRSFYLEKLMNAPDTAEAPAKKPSKTPYGPESFNFVLSLLAYHCMRLDARHIITLGDLAVQYIETLAKSHLPQEEVYEAQCSVFNHSLKLLGSNYRRHSIQQAMPNAFFWETQRILLAVSSKLKRQLLVDAEGFRAIRKVLAGMSKNHVEIHSSVRHAPTWPPYLQPGDGMDEEMDPEESWSRSVRAGMLMQEAGFPKEELDDAVDILQGMSPDGTPTIQQRISLARRRKIGLWEASIRATRNAQEAWERFRNPPKEGLELGLAEYTAMFEKLTRREADEHTTALPGDRALNFPTQQEANLTEFEKARIRPPSISQLYERMAKSRIRPSGSCLAILLANTESMEMAKRYLRDSDGTGELYRLLATEMDVEALRKVPLSLVSAYIQVMTRQGGKRARKYMVRAIELAEQRLGSEQTPWSDYIWGTILKDLSQHHRGLRIHPYQQLKLSLHVVQKLDGPCGISLPAFIQFSKTTRKIAKRELEQLCDEIESSPSTVKNNALWALYDEKSIHKDAMHWDTFGGRPGALDMFRLFRSSALRMKGLFDKLVSLEGESRRLLGTERVAPLDEMMWRRDPARAEHAYEFMITLAYLGEFQQMAQLLKWLISKWGQPEVVQALSELDDVPPYADFVKTLCAFRLLAEPMLGQQAMASLREAIDATGLDWTWPDEEAVEAFIETQEDESIQALARVLERVRLSWTTNTRGDAETEVEPDEQPAGGWRSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7J9</accession>
    <name>A0A2T4C7J9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1215330</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C7J9"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="435"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="811"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1246"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1091"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB77536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1409" mass="156178" checksum="55C599CBA26B0E0A" modified="2018-07-18" version="1">MMGSSHHDESERTESESNPPDGQTLSEAKMEADDQTPIAAGPDQQPGHGSTSSAVSDLAGADRVFPIRSVVRVDPISHEELFPHLTEADKQGPGIPVHLLNSTNRTDSWSDARRSDAEPMSPTSPPPPSDRAGQIRRKRAMSGPYSSLQADAARHSSIPIALDLAISDREDEEGSEAPAGENAGDDKSLEPTDASVASDDRSLEEAIHVSTRFTHVITDEGHAVITGRDGVLQRCEDEPIHIPGAIQSFGVLLAMREEGEGQFVVRYVSENSKRILGYTPQQLFRLESFLNILTDEQQDNLLDHIDFIRDEDADPAANGPEVFGLSIRGRKEKKSIKLWCAMHISPAHPDMIICEFEKDDDQDFPLRPPEEMMEPSASDTLNGNPTLEQIEESTEILSKPLRILRSARKRRGDQGAMQVFDIMSQVQEQLSAAPNLDIFLKVLIGIIKELTGFHRIMIYQFDSSWNGKVVAELVDASKSTDLYKGLHFPASDIPAQARDLYKLNKVRLLYDRDLETARIVCRTKEDLDIPLDMTHAYLRAMSPIHLKYLANMAVRSSMSISLNAFNELWGLMACHSYGNHGMRVSFPIRKMCRLVGDTASRNIERLSYASRLQARKLINTAPTDKNPTGYIIASSDDLLRLFDADFGLLSIRGETKILGVIEQSQEALAMLEYLRMRRLTSVVASQDVREDFPDLQYPLGFQVIAGLLYVPLSEGGHDFIVFFRRAQIKEVRWAGNPYEKTLREGTAGYLEPRASFKTWNELVIGKCREWVEEQIETAAVLCLVYGKFIEVWREKEAAIHNTRLTRLLLANSAHEVRTPLNAIINYLEIALEGSLDQETRDNLAKSHSASKSLIYVINDLLDLTKTEEGHHLSVHETFELLPCVNEALDPFRIDAERKGIEYKVTHHPRLPRFVMGDARRLRQVITNITANAIAHTTSGYVSVDICFAGVKEDRQVLVDIVVEDSGSGMTPLQMDGLFRDLEQVGTEELELRSPFDEKGKNRQQLKTLGLGLAVVARILRNVGGQLRLKSKEGEGSRFVIQLPFQLPKELPETDGDASIHGPVPSSEEISAAKSLPLEKADEILLIDPNKTMSDTASMGRGSIESRRSGVSQDGSQRSDADRLINAIKTPLSIQDKELDYFATGQLPTSASFTGTSFPVPFKEPVNRKLTSNPVDEDAGAAAHVRDSMMPVRAIKVPDEYIDIPPAAMHNRTGSISEADTDGTEPKRLTGGAISDAAAADDITALRVLVAEDDPINMKILKKRLERSGNTIQHAVNGQDCAARYNDGSSAFDVVLMDMQMPIVDGLTSTKLIRAMETSSEHKGHSPLASRCGRIPIFAVSASLVEELKDIYVEAGFDGWILKPIDFKRLATLLRGIYDEETRKSCIYVPGEWERGGWFTESSKAIAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Z8</accession>
    <name>A0A2T4C9Z8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1429363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Z8"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="133"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="375" mass="41827" checksum="5260BDB57BD4C931" modified="2018-07-18" version="1">MESTPSPRETTPETHPTHGVHLSNETIISIINSLIPGSHILAINSLEHGKSFNNRIYFLKIHVPDDLLLHGLHNGAVNYLVLKLNGKFFDETNSKNEVSCLSLLEHFAPDVPSPRVLAWSDGDSSVLHRLTATGSLATKELEISRPEDNGQLHGWILMTRLPGVPLSTLDLDTDELKVVGEQLADMVYRWRHSLPAWASAGNLQCGLPHGKKQDSSSLEVAGLLISPSPNMPGFGVKAVAPIVSPLQYYRVKLEARLQKLQDLDVFTENRHLTPLFREFMDIQLPKLGISNAENSRFFFTHYDLSPRNVLMSADHTEITGIVDFEFSGFFPELDEFVNDSVANAGDWPDALYDAYLSRLEDCGMNTPRRGIREQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA25</accession>
    <name>A0A2T4CA25_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1328269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA25"/>
    <dbReference type="STRING" id="983965.A0A2T4CA25"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="481" mass="53592" checksum="FF0E94BDAE7A44E1" modified="2018-07-18" version="1">MGTAQLSRAMSSSLGARPLSPEAYKVKELPGDEPNDVVFESKYGLRTVLLNRPKKLNSLNGSMIRKIVPRLIEWEKSDMANVIVMKGAGEKALCAGGDVAELAKYNQESPDGWKKSAEYFALEYQLDHYIATYQKPYIAFMDGITMGGGVGLSIHAPFRIATERTMFAMPETTIGFFPDVGASFFLPRMNGSIGTYLALTSDRLTGPNVFYSGIATHYLHSSSLPDLEARLAELRFRDEDPLPRRLELINDTLEEFCTGLPYDQAFSLSGETRRAIDRCFSKNNVDDIIAALKEERGETEEWAQKQLATLKKRSPTAVHVALRQMRVGGKWSISETFEKEHQIATKFMQHHDFTEGVTALLVRKEDAKWQPASLEDIPASENVAKPFFTFDKDAGLKLFTDRTYSEYPFAVLGVPTEKEIQAIVSSNALTPAELAKQVKASRKNRQGVAEVVDEIISRKVTVDEQGKAKWVADEAPTSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAP8</accession>
    <name>A0A2T4CAP8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Mevalonate kinase</fullName>
            <shortName evidence="19">MK</shortName>
            <ecNumber evidence="3 19">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M440DRAFT_1197965</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18 19">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 19"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAP8"/>
    <dbReference type="STRING" id="983965.A0A2T4CAP8"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000027">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="21">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="22">
        <location>
            <begin position="343"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PTB78625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="493" mass="53664" checksum="9D69F2361D961E2F" modified="2018-07-18" version="1">MSDGTDAPSVSFEEAKPAVNGGGQSLLGHQRNMSLRRPSAPMAPAFMVSAPGKVIVFGEHSVVYGKAAIAAAISLRSYLHVTTLSKSKHTVSLRFPDIDLTHTWDIDSLPWAAFHHPDKKKSYYSLVTSLDEELLAALQPHIDEVSADRPEDIRKVHRSSATAFLYLFLSLGSPRFPGSLYTLRSTIPISAGLGSSASISVCLAASLLLQLRTLSGPHPDQPSEEARLQVERINRWAFVSEMCIHGNPSGVDNTVASQGKAVVFQRTDYSKPPSVRPLWDFPELPLLLVDTKQAKSTAHEVAKVGKLNKTHPKLVGTILDAMHNVTDAASELIEDKSFDPKEEESLRKVGELMTINHGLLNSLGVSHPRLERVRELVDHEGIGWTKLTGAGGGGCSITLLRPNVPKEKLTKLDGQFEAEGYQKFSTTLGGDGVGVLWPAVLKNGLHEDEDGMEIDVDLFLNAQGTEGVERLVGVHGDGGEREGWKFWRVESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAV7</accession>
    <name>A0A2T4CAV7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UV-endonuclease UvdE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1328180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAV7"/>
    <dbReference type="STRING" id="983965.A0A2T4CAV7"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="528"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="972" mass="109961" checksum="7DF92D7B9A82C206" modified="2018-07-18" version="1">MKELGEMGIKLQSAVKIQRLAVETSDLSRCDTEKVREEAFKLRTTRKRQSKGGREKKVETQAVETLDVEAVLDADAEAADAPEEKADAEVVERCARRAPPVNSDVLPLPWKGRLGYACLNTYLRAANTPVFSSRTCRIASIIEHRHPLQDPTQPVHSTKNRPDKTQPPDVQRGMQFVQELGLANARDIVKMLRWNEKYGIRFMRLSSEMFPFASHEEYGYKLAPFAADVLAEAGRVAGELGHRLTTHPGQYTQIASPRREVVDAAFRDLEYHHEMLSLLKLPEQSDRDAVMILHMGGVYGDKAATLDRFRQNYARLSDGVKRRLVLENDDVSWSVHELLPICEELNIPLVLDYHHHNIVFDASIREGTLDIMGLYDRIAKTWTRKNIKQKMHYSEPVAAAVTPRDRRKHSARVKTLPPCAPDMDLMIEAKDKEQAVFELMRTFKLPGWDLFNDIVPYERDDEPKKETKRAKKAEKNIPPDEDGGTFSSHLALCAPLSLIITMSATDFDSKTKAFLQWFKALPGSTFHEHIEIADFRQRNAGRGIVALQDIPAETALFTVPRSGILSSETSELKEKLPDMFLGQDTAMEVDGKPQQDPWSTLIIVMMYEYFKGRESKWKPYIDVLPASFETPMFWSDAELDELQASATRSKVGKESAEKMFHDKILPVVRANHHLFPTSQTYSDDDLIKLAHRMGSTIMSYAFDFQNEDDEDENESEEWVEEREAKSTMGMVPMADILNADAEYNAHVNYGDDALTVTALRTIKAGEEIFNYYGPHPNSELLRRYGYVTPKHSRYDVVELPWNLVEESVAASLGLSSEQLDNARAYLDSDELEDTFVLERETEEPNPDGTLTGSARFSEIPEDLQDQLKSLLKAVRKAVPSSIADKRKRDEIQHAILIRALDALASQYPTSISEDEQMLSDSGISERRRAAITVRLGEKRLIQEAKTYLLGLASDAAGTDESSAPSKKLRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBF5</accession>
    <name>A0A2T4CBF5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1373953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBF5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBF5"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001300">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="32179" checksum="0C3BBD223E969B48" modified="2018-07-18" version="1">MGLEKVKHVVLVLSGKGGVGKSSVTTQLALSLTLAGHSVGILDVDLTGPSIPRMLSIEASKVTQVPGGWAPVVVHEAEPESGLGSLHAMSLGFLLPKRGDAVVWRGPKKTAMIRQFLKDVLWDDTDYLLIDTPPGTSDEHISLAETLQRDALPGQVAGAVVVTTPQAVATADVRKELNFCVKTGIRVLGVVENMSGFVCPHCSECTDIFGSGGGKSMADEFKVPFLGSVPIDAQFIALVEEGQRPHYPAGTVVNGQDISSAPEGEHKAGKEDGTLVDKYKDCSLYHIFVGITSQLKDKVAGAEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBK2</accession>
    <name>A0A2T4CBK2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1373963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBK2"/>
    <dbReference type="STRING" id="983965.A0A2T4CBK2"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="93"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="409" mass="46749" checksum="F162CC7808F5DE34" modified="2018-07-18" version="1">MAAAAVQIPRQPDISYAPDYENYLNRTKRRQETEKLDNSLPDGFPAKLESDLVWDGRNLADAYDWNYVLTESDIAEVDQALRHFKSLNLPLGYVTPETFPLPKLHDTLREISKEVHLGHGFKVVKGVPVDNYSREENVIIYAGIASHVAPIRGRQDHQYNGKPADVVLAHIKDLTQEIDPHKIGAPAYTADKQVFHTDAGDVIALFALGEPEEGGQSFLSSSWHVYNELAATRPDLIRTLSEPWVVDEFGKRGRTHTVRPLLYFQPATEDTSQRLIIQYARRTFTGYWGLPRSTDIPPITEAQAEALDALHFTAEKYRAALDFHKGDIQFANNLSIFHAREKFRDSPEKRRHLIRLWLRDPEFAWKTPEPLSDIWDRVYKDVKPENSIFPLEPGVRSASDGKPEERKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBT7</accession>
    <name>A0A2T4CBT7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1300874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBT7"/>
    <dbReference type="STRING" id="983965.A0A2T4CBT7"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015545188" evidence="3">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="228" mass="23668" checksum="1CAF8A7F3222CD2B" modified="2018-07-18" version="1" fragment="single">MRALSLSLSLLAASSTAAAATTCAKGLYMVVARGSEEPAGTGVTGNLTSQIAARVPGSEVVAVDYPASFDDYENSEGDGVKAMREVLNSYGEACPGNKIAVLGYSQGAQVATDTICGGAGDPFTSNKGMSDDVMGDVVAVAIFGDPTHVANMTYDRGSSVHNGLFNRSSSSIEVCKSYASRIISYCDTGDIYCDAGTNSTVHHMYIQRYGDEIVDFVVSQFEKSAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC09</accession>
    <name>A0A2T4CC09_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_48101</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC09"/>
    <dbReference type="STRING" id="983965.A0A2T4CC09"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="278"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="594"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="836"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="102017" checksum="FF348EF61CC970BC" modified="2018-07-18" version="1">MAAVVSEGAVLVALKYLYPAAVFLYYLASTLLATCTLQALKKTQHARPERPGRRAVIYMLGFFLFTYLAQLIILGTQCIVEKAAPLEHQVINYLSCTLVFGILFIQLRESDTVVWYPFRGSWFIALFFEATIAALTVLHSSQTVQTTYTMLNMAVVCLRLVSLLTLAVWTCLGIWTKARAPATDQERQLLLPKPDGEQPDTGATAGKPANSTTYGSTTQSESASNPEYIWERRDREARESMEKRLEEVGNWWEYAKGFAILFPYIWPVGNRALQLRVAAVMLCLLVSNALHLLIPRQTGIIMDTLGGAFGSPWAAVLGFALLRLAASESGIELVRQWLWIPVKYYSQDALTRASYSHMMNLSADFHDSKSSSDMLMAIQGGYAVSNGIENVLLAAVPMLVDMCVAVVYLSITFGPYEGLITVATGTVFIMFATRLVAESKAASRKRVNAVYQEHYIRHSGLIGWQTVSAFNQIGFEDNKHANAVTNRWLNEQQYVMSWFVSIAFQTTILTAGLMASAFLAVFRIQKGQATPGQFAMLLMYWAQLTAPLQFFAKMGKSMSDNFIDAERLLAVMKTKPTVQNKKNARPLKFVSGEVVFEDVCFSYDKQKNIINGVSLQVPAGLTVAFVGATGAGKSTLLKLLNRFYDVTGGSIRVDGEDIRDVDLFSLRDHVGIVPQSPILFDDTIMNNVRYGRITASDEEVFEACKAASIHDKILGFTKGYDTRVGERGVKLSGGELQRVAIARAILKQPDIVLLDEATSAVDTDTEQQIQRSFKKLCQGRTTFIVAHRLSTIMNADRIVVVEHGKIIEQGTHDELIKANGRYTDLWSKQIFLKPQDNDGAKVSDDAKTLANDSCSERTSTEPCEPQDEGAPAKVAQEGDARAAQESNGRATQESNVKAPAGKKCQKEVDSDINSDVPRDTDGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCN3</accession>
    <name>A0A2T4CCN3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1327028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCN3"/>
    <dbReference type="STRING" id="983965.A0A2T4CCN3"/>
    <dbReference type="OrthoDB" id="5425130at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="772" mass="80133" checksum="3B3BC7379194AC15" modified="2018-07-18" version="1">MLRPSDRVASKSGTSRYSKALPGVPGSDDYDDADDDADDTSDSKSGAGRISGAKDSDPAHSRSNSAFSLPARTSSLASPPPPAKDLPLPPLPTKLQLNLGDSNGNSKSYKSSANSPVDNIRQVTVAAPSPVSSIATSAPSLQSPPLSARSHMMAIPRKPIANLKPPSAQFLDQPSPTFSMSSILMAYMDDDDESQAESQGMSQDGADEKQRDVAAGSNQHYAASSSSNRTGAASERPTAASAPSVVSARGSSGSLPARPNAGKDRNTRPADGNTAPPPPLKDRTATPLQKPSAATLTASPTSAPAPALAASLAKPLPPTDSSELAAPSSPRPEIWKRRPHMTQGSSEVSGLRLDSSNGSTADTQPSWDASTAPETVSTDKAAAQRATPFAGGLPGRNIRPSLPLKDGPIVSAEAMGAETSKMKHIKDKLAPQRSDSVPSNTAGAKAGPASALVAKRPPTPEYQKEEVKEPAVEPFISPVSPASSPEAPRGASPDFTMKGLPPKPSNGGQPVTLPSGPKPIARKALPSQPSQDLTAAKNAFRQQPNANSAGASSSQASAVSVPPKVEAVPAAAPAAPTAPAAAPTPAAPLKDAASIRLVSSRDAPSVQAQPAKERADAPQAVNPQRSMPQVTSDSRVPQPDAQGTAYRGRDGTVYAEMKTGGEPNPKAAYFPKQSIPGLMKDGVAKARPLRDAHFNCFQKHRSMARRSNRNCPLTCQTCDRADVQDRWVCAFCHLRICDSCHRRLDGYQRDLRRFVDALAGPSSSRPGTSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD36</accession>
    <name>A0A2T4CD36_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1170351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD36"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="159" mass="17412" checksum="4981654CA8B7A04E" modified="2018-07-18" version="1">MYPGGARSTVSAHKLHLFVGRVCTTASFFHASAFSAIFVRRDAETWNFKKVISCLFLSIQQQQQQQHHHHRIHCQSAHGVTSAHADKLCYDAMASDQRSTAPMSVGSSIVADDWGQVQLACRGWQGFAKPLKACWQSALLGGAWIVGSWVKSGVGLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDB1</accession>
    <name>A0A2T4CDB1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1326436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDB1"/>
    <dbReference type="STRING" id="983965.A0A2T4CDB1"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000260">
        <property type="entry name" value="Mitochondrial ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="97" mass="10919" checksum="C657975E36E783CA" modified="2018-07-18" version="1">MITKFMTEVTAKFNPFSTCAKPARLFLTFLPPNVRANGTTVHTSLLPRNSPESSSLKVKFKDGKEMDFNCSKTNIKSLIEEVDRHSRQLQKAADLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDM9</accession>
    <name>A0A2T4CDM9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1428949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDM9"/>
    <dbReference type="STRING" id="983965.A0A2T4CDM9"/>
    <dbReference type="OrthoDB" id="3648773at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="540" mass="58619" checksum="113F4255C1F391AC" modified="2018-07-18" version="1">MSDNRHANAAAGNTTSSRDVKSAAALPTSSKPFGSANHSYSYFDLAVRSIPGPPCFLLSLTPTATNAQEQPRSTPWERAMQDGAFSNPNSPRPSPQHRPRVNSVSTSSKFGVDPPRPPRDGSNTRFWKWRSRSGKSVSETDAAPEGPGDPRMASMSGPKLRYEPSKQDMPPIHQVWTPYLSESDHVFSLQHPTAPPVSVSPGTVVRTPSKSQQSSESSLASPGPKRGRPMGIPEEPLPEGGAQSSLKPAAPMTPLISPRVLYLKAKKEIGSKLKHQQSDDPYLHHPTDAGHPTGPVRGTGRSGKNQAPDEDSRTRSTIEGARRFLAAQSISRTGTWFRDEHHALRIGRKLFGKAPWHRKESNDSINSVSSSVRAVLKGQTPPASPAKQWLKYTNSYTTSNTTFPGGEAVRVSTPPLDEDTADGRPRGFFSSLTPPLAEGETSIKATPPVRLTKRYSVHGHPREWWDQMPQRTGRRDLPGAAGNKFEFDVLEHLPGSPLCPADKRHKSGGTGVCVYHGRRKTGSNLRGEASRGDYSSSDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEE5</accession>
    <name>A0A2T4CEE5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1106289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEE5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="9049" checksum="09DD7D055F4F864C" modified="2018-07-18" version="1">MVCHYSCSFFLTSISCNSIHSHEITLPALKNRGDIVKFSTQLKYTLMLVSLRDQTNKDLPTIQIALPISSRIHLEITVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF29</accession>
    <name>A0A2T4CF29_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_182016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF29"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15483" checksum="7F9EBAA88567F3F5" modified="2018-07-18" version="1">MTTAFHAHITSNRQEGCSLIQPYLPTFTSPYTLVPPTLFSISSLFFSFLFVMTTSLTRPRLSSVVTGCSAVLSFRLLSGETNRPHTHMESIFLFFSLPCLVLATLVGHTGLCRVPLRDESRTGNWRQEGENDKSEPPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF70</accession>
    <name>A0A2T4CF70_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1118784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF70"/>
    <dbReference type="OrthoDB" id="5152716at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="145" mass="16361" checksum="C680C1460CA06A19" modified="2018-07-18" version="1">MLGQTENSAPRLTPASQQHLNNAKSTKFTSSRRIHRIGSSSHPGQAPVCNEKGKETDTPVRRPSTPTLPACHEGKQQTGSRSSREKTTLYTAAARGNRRHPCGQSERTGNIHSWVLRICNHQPGWIRWLFWEPKRETNTIEMILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF97</accession>
    <name>A0A2T4CF97_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF97"/>
    <dbReference type="STRING" id="983965.A0A2T4CF97"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="437" mass="47563" checksum="0D0AE91C0DD4E3C9" modified="2018-07-18" version="1">MTSRANLIARTVISQFDKLPSKRKPCVRDNGFTEWVPLSGIVAERNGVLTCLALATGMKCLPASKLAEAKGVAIHDWHAEVLAIRTFNRFMLDECQTLIESNCHEHESILQRGHPWGLDAEDGRFTRPFVVKEGVKLHMYCSEAPCGDASMELIMAAQADASPWQLPAPQPLSSSASTDAEQNPTAQLPGRAYFSQLGIVRRKPARGDAPPTLSKSCSDKISLKQCTSLLSSLASLFVDPANAYIDTLVLPESQYSAAACERAFSPAGRMKPVAGKQWPGGYAFRPFKVEATSVEFAFSKRAVQARSQAISASNLAATWSASGVEESILGGVLQGRKQFDVRGASKSSRRQMWNKAKQLSECLSTPSSVSGPDKDAENVPDDDRHRALQEHLSSASSYQEVKDGPLLDERRHVKAQTRELALKGWVQTEGDSDFGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFK6</accession>
    <name>A0A2T4CFK6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1323869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFK6"/>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="246" mass="27173" checksum="76C97EBC6A53FC6B" modified="2018-07-18" version="1">MPALPPLPRQLIDGLAKVAQLSTKTIHGDATSPVVRQRDSATTTFVVIPETYGDLHDSLSPGAIVGIVIASVIGFILLLLVIYTILGFGPVSSLVRTTDMTESKSYVSRSMLSSLRKSEKPNKVPTARGARVLSMRREHSTRTSKRRSERRGKSPVVVEPMRKTRERSPLTTISSSSGGRGPAPREDPLPSDYDEENEVVVIEETTPSSRRHSRRAGPSRGGEGRGRRSSSRRSSYSEYDDRRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFW4</accession>
    <name>A0A2T4CFW4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1369638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="PTB80434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="RECA_2"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="39"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
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        </location>
    </feature>
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            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
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        <location>
            <begin position="408"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="417" mass="45032" checksum="7197F38FE86B80C8" modified="2018-07-18" version="1">MDYHAIHGHDIASFDTSESTHRLPTVPASQAWEELKASPATHISTGLDALDRALLGDAADSQDAAVKGGVKRGQVTEIWGPPGCGKTALGIQLAANALSDGNGVVWVDCFQNLQTQRLASVLKSVRDSRILAGSGEIQDVDPSKLVHYSCMTLPHLLAFISRPTTTSIPPDVSLIVMSSPTALINSFLPRSMDGKGNLKQAKGPTLASKRLQGLQFIMTTLQKLAATKDCAIVLLSQCATKMRSEQRATLIPSINTTVWEQGVSTRLVLFRDWAWHGNKSSSVFLAGLQKVDGRAVQDAVDHVFAFKVEAAGISSVHYEASDPGMEVAVVAPRPKRKLGQTELEVPDSEDDEDYGWADEDEDALPPPPSQWQGSEDLILGKDAGLSEDEQEPDDGIREYYFEDDEAGEGDRSNNEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFZ6</accession>
    <name>A0A2T4CFZ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1127828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFZ6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="224" mass="24231" checksum="8978B622E645E0CC" modified="2018-07-18" version="1">MMNAKGSGARSWPWLQPPRRRYIILGCLVHAHGLESLPSRPRNSQVLVQPQHLAPLPHSHNEQVPAWSHMVHATGSIMGRRPLAQPRLAAVQLVGRLTCSYTDPATSGSFPDDCTPSGELRKGARQSTEGQPGDAVRALIVSSKSFGACTHEGSVDWTRLRSSRGWTDSEEGCLVSRSCLDPCSLGVVHRARDPGRPVHVAQRPPCIGGSCQRGACSGLAAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG14</accession>
    <name>A0A2T4CG14_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_196132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG14"/>
    <dbReference type="STRING" id="983965.A0A2T4CG14"/>
    <dbReference type="OrthoDB" id="5243589at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="787"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="909" mass="101299" checksum="86C1C078C72DEAC6" modified="2018-07-18" version="1">MEDIVNLILTPFKDIVDKGRTAVQNAGDTQPMLKASQALLKEGERALKKIEPLCKKHFDDFGPNFIEAVKDNEAIAQYRVQLTELLWEFDDYIEVDDFDADKFTELQMMSRTAAPKIYDILLKMKLEPPAHFNQEHFMSQLSPPSSPHPTPPMLMPPVLTAPPSAAGASSAGRDSMSSCKTDSRSATDTTPVETANEQLSVMIDKAFHSEHNGLNLLTQPPPMPPPDRGLPLPPARPPVTVEQVPPRPPSTSPWDIRVKTVVSDDERPRDAPPARRRPPVEPPLLTPVEGTSPISPFTTSRNFSVPRPNYPDTPRSSGLLQEYSPESDEKHSSLSTLSSQLSNFSMSPTQLSRPRAPSNHSATTYSSSTPTIPEEMVRAKDMRSRSSSRPRPAPPMYSPMPYRAQRPRQPSHPASTEERMDDANTILRDDMMSDAVEQSSDRRMSADAESLIDPNPLPISTRDRGLSDTTHREQQSPKQPQQQPGLELVRRNTDLADGIDSGLIPVDPSIPGAVLANLPPQDLSIDNLSSFYLQKQFCAGATDVINGGVGVKRQKKPVGFSMTAVVAKCTHCLYELDFKHLEYDINKQDEGNYTKHGVGYRLRFLQKSHLHAKRVDDIMYACVFCIHTSQTLDQSDATVFTSTAALFSHLARHPRPLPDVPGISVVDQTEVPPHLVNDYDLLFMNPPEPHPVRERATEIAHLPTAHAKESARRLFGQRLLPDRTPALEFIQGAKITGITWPSRYNGEWAFGWHDGVHASIPTDILKLDRPPFGHIKRNATSRIRAKAKWKFAPKEKNEDWLKFDKDEVISNITWSYPEYWCWAGTNAKGKWGIFPQAFLDPNSLQEIASVISSDRASILSNEKNRSGTMLSKFPTRTMSGRPASVAGSTSSGEKSVFGHSRSLRRSREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG16</accession>
    <name>A0A2T4CG16_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GPCR protein, PTH11-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1324483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG16"/>
    <dbReference type="STRING" id="983965.A0A2T4CG16"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="56279" checksum="CF0633AA88A2E8EC" modified="2018-07-18" version="1">MSIYSSPPSLRPFPEDKPSLLVCWWATIFCALMILLRIVGRFIRTEKLFTEDKVVALALIPLFLRMGCVHFILTNGTNNSDFAGITLTSEQLHKKSIASGLVLLARILYAATLWILKGTVLEFLARITDLTWQRSQRYTLIAIRCALGLTFIAVVISDLVECHPFKHYWQVLPDPGGQCRQGFVQLITLATCNVLTDLLLVIFPIPLIIQSHMALVRKIQLLLLFSLSLSVVGVTLYRVPLIIDAHGRQSYRSLLASVELIFAAASANALVLGSFVRDRGVKKPKPRRTSTAAESFERSAVRRPTMQRQWGSDEDLVRDLGLAVEPELREQPDTPSDDLYAPIQPMRSVGQDRQQQWNRQQQEDSAPESGQQSAQESGDLLIYRTESPHESRKLSLFDVGGLLEDSAGTSSASYRRGSSYTSSSMDASTSQNPPPASRKASASGVRRGSTALLQDLGGLLSPLNSKSSGRSKPRTGTELQTIPQSHQEHHTTPGEPSNLVLMDPGGLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGE9</accession>
    <name>A0A2T4CGE9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGE9"/>
    <dbReference type="OrthoDB" id="4366798at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="591" mass="67554" checksum="90EE19E4CF354410" modified="2018-07-18" version="1">MNYTLPQINIFTEEEWSWPFHKFGLEREDLFTTLHDRFNLHQLPLQDPMAFHRDVCESAHHSATLEEFYSQMEERKAQRVEEMKEAWRNICLLIATDYLVLACPLCYDPETDTVRTKPGTLNDSVTEKWHLFNYFSRTLSFDTLIRFFDGFVRDNREEDDRLWGPFRERMRKWREKQAAKRAAAAAAEATEAVSQSSPEAAHSQPESSYDTSSPDTPSDNPRRSTTRRRHSAATNPSSPACSTARKRKSDEDTRETRRKRRRSSCQSVGDDDDAVWIAAEYDSSGGDEPASTTRQTENSQRTDDDLYEQGQKRSGRNSPESEEEDELLHESNSSNEQESNWRRRSSDGSEEEDERAHISVMDPQKAFYLPSEDDTEEEDERAHATVMDPQKAFYLPSESLSENVTPSHDPMPTLNPMATQDSTAERPASTQDSLSTPDSMVTQWPMLLPQDPVPSRASSVDSYHTCPEAAEEERVADSGHLAETQTTSQEENTEGPAASDTTNYAANAKKQKKKSRALRRQRAENRRSSEESEQSPPQRKPRQRKRQERETSTPVEQLLQSRRSSRRNAGQTLFFLGDDATACVASGNRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGS3</accession>
    <name>A0A2T4CGS3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_203185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGS3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13407" checksum="CB0A8DDA125A074C" modified="2018-07-18" version="1">MISKYLFFPRFPYSISRLLVSHTMILVLFLFFFPFLFLPLFLFRMTVRGWFRVSLRAAVSIQSSLDQLVIDGGGLWYGLSSVFSFSFLFFSCSVLFAFCWSTGRPHLRLMADTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH16</accession>
    <name>A0A2T4CH16_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1395987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH16"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    </dbReference>
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        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="282"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="412"/>
            <end position="480"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
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            <end position="273"/>
        </location>
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            <begin position="459"/>
            <end position="470"/>
        </location>
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            <end position="541"/>
        </location>
    </feature>
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        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="652" mass="67547" checksum="90505A6420E1376B" modified="2018-07-18" version="1">MASHAAAIAAETPLSPGPTTTPPPVLPLDDVARLPKRRRESESEPSRAAASHRLSSESPPSKAAKLLLASGQSPLPSNGAVALEDERRHREEEEGGGGAIEQEVVAPAPAPAAPSTTTTADGGAQQDQTASLRVDGENPSQPALLTLLSAGNQAMSRPSDAPQLAPTATMEPSSKLATAALSISQNSGERIEERSEITTQSPASIAGAPVTESPTAMEVDVKGDPLASQQVAIQEERPQPGSLSYPGSLQTTGSMPDSPVRNMSFPMPSQSQGSPPPSANKKHKCPYCNTEFTRHHNLKSHLLTHSQEKPYVCTDCQMRFRRLHDLKRHGKLHTGEKNHVCPKCDRKFARGDALARHSKGIGGCAGRRSSMGSFADGDELDGGMEGDEAVMSGIAYDNVDEEELRRQSLPSMGVQHLPGGQADQYSSHSRTYPPAGARGATAASLYAPGGGQNPAATTGSSSVSNSLGGSHTPNTSISSVAVGGGPAGLYAQAGVPDVAKPLSPGGVQAHDGSGIVRQRSPSLSQQLQQQQMGRRQSDMQSPHGGQGRPKLPGLTHPGYVPAVSPAFSHGRPPTASSTATATAAPAPAPAPASAPSSGDSGNMFAQSDPSVWAYIQTLEEKVKSLSDKVVSLDHEMSMMKKQLAGTEGVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHH5</accession>
    <name>A0A2T4CHH5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1004852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CHH5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="IFRD"/>
    </dbReference>
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        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="85"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="464" mass="51743" checksum="594CA9289E13123E" modified="2018-07-18" version="1">MMNHARVKALKGNGKTVSKKAIKSGRASGASTPRGSPLPSLLTSPSHSAAQSRVTSDVSDEDVDFELDDMASSVYSGGSGEEMTDEPDTHIFDVNAFMTSIKDRKRNNGEMREQSLSLYIHKIRHQYTAETHLWLDDAASELAELFLHDANRAATAKERLLSLQAFVLTVGTVDNLEIYDSAQRILKQILVDDDDDDCRVYAIYALCMTVLYAGGMEEAALEVMEYFVEIVRTDGEHIDAHDNVVIVAAALQGWCFVASHVADFSDYADAAMDAFVDQLDSDDVEIQSNAGGCIALIFEASRHHLEETGEPFQLQYDPQRLADRMRELAKLSAKSVSRKHRRNLRESLVSVVTSLERGVGPFYSTAQYIPEKGEHVPASLRTDEGRAEYGYRCKLRLNSQVAKVDNWSLYFRVNFMRIIFKGGLQHHVFINPVVTECLDDAEFVQDYSPLQKPPKGRKNISSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHW4</accession>
    <name>A0A2T4CHW4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_77849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHW4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="146" mass="16926" checksum="2C96F9923C35975D" modified="2018-07-18" version="1">MILCRLQRIICLLPVQVRARCRRVQPKVQRHMFSHGLLHITTKTVIRNLNIQTNGHTSFKCNKVRRFESCPRWDSRSRELCSSNTTLPLLRTTTTTTKYLLLPKLSFSPRFQLRARPARQTMVPKRSTGVGDPGRSPLAAHRKCYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI00</accession>
    <name>A0A2T4CI00_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sodium bile acid symporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_45997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI00"/>
    <dbReference type="STRING" id="983965.A0A2T4CI00"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49228" checksum="86B0A1B4907BEFFF" modified="2018-07-18" version="1">MTKTTEKSSWRENKALAAIWTGVEFVAAQWLLIGFGVACVLGCFFPHVAEHGGIIRSEYSVLYGAVALIFLINGLQLPPEKLKQNLTNWRLHLMVQGCSFIIIPVIMLIFIHICLAAGALRHGTPSTPIILGMLATACLPTTIASNVVMTRSAGGDEAAAVISVVIGNTAGSFLTPILIYGFIPRGAAFDAWRPADPSTLGDMYTNVAKQLGLSVLLPLAVGQGVRWWRGDVVAKVLRVTMLGKLPTVCLILLVWTTFSGAFGTGALYKLSKADVIFNVFINIGLYIIFTLICFYLARPPAFLARAVNPHVAASRLPARVKRIVSVKKMSEEQTIAVCFCGAAKTTSLGIPLVTAMWTQADDLTRAFITIPVLLYTIEQVFMAQGLVYFFRWYLRRDKKPGRGDIEDVISEEQPASTARGDHESDVTAHDNDDEEVGQVSAVRAEEKGVIKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI15</accession>
    <name>A0A2T4CI15_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1345820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI15"/>
    <dbReference type="STRING" id="983965.A0A2T4CI15"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33970" checksum="45CC8B899277F041" modified="2018-07-18" version="1">MAVLGKRKAPEPSISTEDAQEIFRRHFEAQFLPLPEAERKARAKEEDDDESADESDGSEGEAGEWGGLSNDDDDSGDDEDDSDELDEDDDDSPTVEVVDHSVSQAPKTSTMSKRELKAFMSSRPPDPTSSSSSSKPTPQPSAKSSAALPEDAPSLLAQDLELRRLIAESHLLQTNKPTSLSAILSSSSSAQAEPKAFAAGRVRQKALDLRIQALGSKTSILKQEKMPMHMRKGINAAATERETKRRREAKESGVILERETGKKKKRERKSGGGGVGFGPAVGRMRGAELRISERDVKKIEGARDTFGRRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIG4</accession>
    <name>A0A2T4CIG4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1396504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIG4"/>
    <dbReference type="STRING" id="983965.A0A2T4CIG4"/>
    <dbReference type="OrthoDB" id="2274804at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="226" mass="25318" checksum="BD660E5CCF09B522" modified="2018-07-18" version="1">MSDADEAMTGVDGGDSRLPLSEDETRVLELYDRLQELRLEIAIINAQRAGVKDDEDITAAQNALLTARARYKLRNDAIEAVMMANPILKAVHSGTQASPIERDLFPYIEQRDETSISVAKHADSMAKLRRDLTSVQVQSIRVCRDNVKLTTQVFELAEQAKQRKAVRLDDPDVQREMDKLTREVKASRQRWKVMKGVASGIVAGSGVDWAADEELRNIVLDPEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJH2</accession>
    <name>A0A2T4CJH2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_357766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJH2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="13530" checksum="431E2C7E466F2941" modified="2018-07-18" version="1">MPLTFWSWFACISSSSMLFIPSDLNVSSSNSEPYGCRAWSTPSSCLWRTNKTLVRLYVLLFSQIKLLVYHCRRSRLTSFSRSSAGLKCNFSNSRYTSPKTDSALCRFSALPSFKVALAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJW0</accession>
    <name>A0A2T4CJW0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1321286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5376287at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="499" mass="55764" checksum="66FD876F7AF22D8D" modified="2018-07-18" version="1">MRTTLRRSCNACAKAKLGCDLRIPQCSRCIKRNSRCVYANKPLNSPLENLSLSAESSSCSSPAAGNRGQLFAPLPQDGEIAVQRPENPAWIRNPATASFDPFDSYPPTRLPRMHVQRLIHRFLSSIAFQYYPLDLNMESNPFIVSWWPLALADQALFHVSLQTASLYEELQAQNGFPISDLLMVDSIALVRRRIEDPSLAFQDETMDSIVTLAAIEHGKGNIEASKMHIEGVKRMVSIRGGIDELKQRSPLTARMVSWVSMLVMEDPQFPIKDDAGDGDGISAIPQWQLALTDAETQGESLATLNVTPAMNDTLSRLRRILHHPWHSSLTNTQLHDLTCFIVHKLLLLPPLTDTSTDADANPSRWAASECLRYATALYMLILHGTTYYSHVGLANAIIRQLRYHLVALQEAAAISMTARAPSPLEIWALSVGMVATTGNGLHRDHEWFRDQARASAAALGVSKWDDVVPHLQAIIWARMPQEELFRQEWERAFVKTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJX1</accession>
    <name>A0A2T4CJX1_TRILO</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1347035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CJX1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF1">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="506" mass="54155" checksum="FD12D853F87C79BF" modified="2018-07-18" version="1">MPPSSKCSAWLRPRNASLGFLYIALVTLSLFISTSFAISSPRATKANDKTGNWTSLTCADPAVLDPLDMGCAQRWSELDTDDAWKEVIRIWTQQDEGKTTFGASVMNTLHAPDNETDCGLLGPRRNCNQALPCHFFQGNSTDRGSGPAASLIYESFVVINEIQYSLYDIISNTALDIMTLSLPYIEGTFAPAAPPEPDAAWVPILRNMLSLGITAVSASFFNQLFGALAVRGDAGADAAKNLTYETIALTAASVFATVSGGSKKQWTPRSQSTFSATMGHVFSGWSAVIENQLYTLFDGSEASVKLLGSTLANGNLLECNNTIVVDHIDPNDQMGNFIQKVFHALAIPGLWAVSGTKAFVVNSGSPCGTINPLTEYMTEATQEATYSCHNGSLYYLVYPGDDRHGYFTAPPGLDSIAKGLWGNLTLSDLIAGSVNTYVANGNTNGGPPANMQNQQTLRDLTTQDITTPGFITLPVCSAEVAWASWSNPSRTNSSAPNYPCNPLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJY1</accession>
    <name>A0A2T4CJY1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1347061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CJY1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="6">
        <location>
            <begin position="414"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1376"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1599" mass="180011" checksum="5869E01DE5524689" modified="2018-07-18" version="1">MPEKPHNVFRRLHHGRLKSNSRGDRGNVSMDSTATPTTGQSLVKSPTEASLDLLLRPARTTDVATETPTTGTQTVPTPPRSEESSPEPRPSNGQRLWDEAYDAIKKDDAKLVEGYERILSQYLRAEGSIPNSDTAPPNTISSKNRHMRRQQMDELVRVGLRRTRREGKSKSDGLEVAIDIVHTLREMVNIAVSAVPQASIAWSGVWVTLGIVENAANEAASYRGGLEHVVTRIRWYGNLSDVLLEGSDLDGAAVCGMKNELETRLVELYRALLTYQIKSVCSFYRNHSYSFLRNLVKLDNWAVSLQEIQKAEDSLRHDIGGFGNQQVRSRLEVIVGHVKCQEREIQDIARRLEEQLRRQINAEDQECLRDLWSHDPHMEKKRIENTKGGLLQDSSNWILKNKDFQRWFQDPRRSLLWVRGDPGKGKTMLLCGIVDNLQKLAPSSLVSFFFCQATDQRINKSTAIMRGLIFLLIDQHRHLLKHLSEPYVRQGKSLFEPPSAWYALSYILHSVLKELNDRRQPTCLLIDALDECAQEDLPRLLDFILKMSKEIPYVKWIVSSRNWQDIIGKMEALGSEAQLSLELNAESVATAVHIYINQKVRQLSEIKKYNKDREDKIRDYLLANAHGTFLWVALVCQNLESIPAWKVLDTLKASPPELEPLFRKMVESISSSNEAKICERILTVATVARRPLTLQELIALAETPGETHEKRQVVCELIGQCGSFLTIRDEVVYFVHQSAKDFLSEMMMKQELSTGMNEAKHYMVTRSIELMSQCLKRDIYQLSELGIHIDAVKSPIPDPLAAVGYSCVFWLDHFADLNDREDCETVSDEAQDTLVCQIQAFIGNNYLYWLEALSLLKKMPEGVVAMRKLHEYFKTRRGSAALIRDAYRFILAAKQTIEDYPLQVHPSALMICPALSEIRQLSLREQPLLFEMKHGIRPSWDPCLQTLKSGYKYASVAISPNGKIMASTSESGAKIWDMATGTCLKSIQGPYEPSDVLLFSPDSRQVAATDESNGICIWNIESSELIMRLEHHNNRFCDLAFSPDGRLLASGSTDFIMIWDLNSGKCIHKQDGHQDAIIALAFSPDGRRLISCCHRGTTIIWDVAGNCMSTQSVHEHRGEADSYIPCISSDGSRIAFVFNATSLILTRPVVAIRDTASGQYIRTFEHDDWVLGTKFFPDGQQLAVFSSDEIQIWNSHGDDLPRTLRGHADDITSIAISPDGSRLVSSSRDGSIRIWDISPELEDQWIRGPIKRSCTAALSPDGVTLALGANDYDYGDGTIDIWDLLKGEQVQTFTEHTSAITCLEFSANGKFLASTSRDRAVKIWDLATRACKKILFTPNGMIRLLKFSPDTLRLASLQSNKIEIWDLASGLSMELQGEHGDRQQTISFAMDGKSLAAGTTSGEIQLWDYVSGQCRQHFKPPREMLLWFDHDVTCLAFSPDDATLVSSACESIAIRRKIDEEFRIVQMLEVDYFVWSVAFSPDGKQIIASDEDDAPSRTDVWDYDASSGSATSRRTLQCTMESYMSSTFRENDDQGATESNLYGLNEDADAITRNGKLILRLPAPCHSFQTTRLGHLLVHGNTLVLHNSVNGLLILSFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK63</accession>
    <name>A0A2T4CK63_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_16230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK63"/>
    <dbReference type="STRING" id="983965.A0A2T4CK63"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="59222" checksum="82D03F2825E6E6E5" modified="2018-07-18" version="1">MLLYEYVNNLGGSHVATLAALGVSVLVVLLARLFRESTKGSEAGCKPVTRVRQWEPFLGLDMVYSQLQALKRNYYLEWLRNLHKGKPKTFAITFMGVKQICTTEGENLKAIQATNFKDFGLEPMRRKTKGAMPFADKGISTTDGKNWEFARFLVKPFFYREVYASIDRIDPYVRKFFTLLPEEDGVTFDIQPLIQRWFLDLTSEFIFGKTMDSMTYPDRADITWTMLDVLRGGRLRIQMYKFLWAFNWNWWLKAVYEVHDFVNVHIRSTYKELEQREQRIKDGLPVGPERVDLLWYMATHVRDEEELRSQLCLVFVPNNDTTSIFISNCIWHLARDREAWQKLRKEVLDYGDQPITFESLRSMPYLNGVLNETHRLTPNNIVQVRACLNDSVLPLGGGPDGKSPLYVNKGDLVSVTKTVMYRDPDVWGPDVDVFRPERFFGVRGNWNFLPFGGGPRRCPAQMMVQTESAYMLFQLAKRYSRLECRDPEPYTAVMRIGPSNVNGVKIAFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP68</accession>
    <name>A0A2T4BP68_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase/Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1406834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP68"/>
    <dbReference type="STRING" id="983965.A0A2T4BP68"/>
    <dbReference type="OrthoDB" id="3335528at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="322" mass="34721" checksum="18D3C56D569E1D99" modified="2018-07-18" version="1">MAPRISSNFHVHSGQRHLKWSKAITPVLTVDSQDVVTFDTIDGSNGQITPTSTIEDVLHFKAELADPLFGPVYVRGAEPGDTLEVEVLELKTSDWGWTAIMPGFGVLTNEFPEAHLKIWELDPRGSCATFKDGIRIPTHPFLGVMGVAPAEGECPTIPPLDTGGNIDTRHIIAGTKLFLPVRAPGALFSCGDGHAAQGDGEVCGTAIETPMQVKLRLTVRKDMGWVTSPNYTAPSSTLTLAEDKGYYAVLGVDPDLLEATRKAVRGIIEYLVQTKDLTRVEAYMLASVSISLRISEVVNVPNYAVSASVPLHIFTDTSSHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPF1</accession>
    <name>A0A2T4BPF1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1442809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPF1"/>
    <dbReference type="STRING" id="983965.A0A2T4BPF1"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="194"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="482" mass="52224" checksum="BCA2D77ECBC6C2CD" modified="2018-07-18" version="1">MSGSPAKEAPAALSIQPLQPPPSPQTHRALRRLQSAHALGARAAQQATLSSQQRRERPLSPTRAAADAIADATAAASSNSNSHVTNAHLDAPAHATARARGRANSDATPPPPYQPAMPANPRRTGVKKPVFSHGHLSLQQIIREGPNNGDFLGALESARWKVIDEGVKAAEDGMVRASSLALFFDAVENEALADLCLHRLIYVWLVLLDAPIMSTDEYLALIHRGASPAYAKIRNDTFRTLTTDPLFRRRVSEASLIRLLNAIAWRLHDSKEDERQSRPSSSHSSLPARDAVGGSHSGQSQARSGAVLEPGVYVQGMNVLAAPFLYAARSEAEAFVAFHSLLTRECPGYIRGAMDGVHRGLALVDKVLAIVDPKLSMYLTAKGLSAEIYAFPSVLTLCACTPPLPEVLRLWDFLFAYGPHLNIVCIVAQLTIMRSQILQSQSPNKLLRSFPQINADLVKSITISIIKKIPDDLYEEIATHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPG3</accession>
    <name>A0A2T4BPG3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_62797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPG3"/>
    <dbReference type="STRING" id="983965.A0A2T4BPG3"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000103">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF2">
        <property type="entry name" value="N-TERMINAL OF MAOC-LIKE DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="348" mass="38665" checksum="509A17EF1D0AEA6B" modified="2018-07-18" version="1">MRGFNHSKRAAKQLLFQTTRRSSTTPEPQIRTAAEAASHMMEHFGQKVTKRSQHIDSNQLQKLAVTLGRPVLDGHDMRRMSAPAGTPVPPAHHLVYFTPFDVEADLGADGSDRTFNAPAPFTRRMWAGGHIKFDRGNPLRVGDEAEEHTKLLSAVAKTSRSAGEMVLVEVEKKLYGSRGLALADKRSWVFRPVIQGQSEIRGGVAHRSVDGNILAPSSVSDVILDDHAFPVRKLSWSPVGLFRFSALTFNGHKIHYNEDWTRVAEGHPGVVVHGPLNVINLLDYWRDIHGQGTGPDEIIYRAMSPVYAGEEYQLRTLSVQSINRDLVFEVVAERDGVVIMKATIIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPP5</accession>
    <name>A0A2T4BPP5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1452097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPP5"/>
    <dbReference type="STRING" id="983965.A0A2T4BPP5"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="689" mass="76322" checksum="62BA6C2D2D52734F" modified="2018-07-18" version="1">MAVKARGNSCTECRRRKQKCDQGRPCSNCVRRFPQPTCEYNAKRNTKRPTTAGSPGSSSKNVKVVLEGAYAHLNLSDIQDAILQVEGVVAASGIADRSSATPVVARGEMISLAQPDDQDASSHNSSEPFRVVVTDETGTLKPKSVFAMLRLILQARLKVTNRIVNDEWSIDGPQLMRALQQATQPPAMLGGLDDQLRNLPMEPTRLNIELVRIHLQLLSRFKASIDGNPDPESRFMKHWVPLSIKDPLLLQIVLYTAVCFLKETGRVPKMLVWAYKGVVHRMLNEHLSSTRTQTGDAAIMGAAQMVMDSWYWGTTEELRAHMAGLKTMIRMRGGLQDLGMGGFLAKTVLIHDIAIAIAHDIEPDIYGKAEFDFRDDFMVPYQTSFNSPFLSGWPRFVDPGSALKLHRSSAQILDDVRLVIQTVQSLPPCPTEQDLQNVIETALWASNRLDRMPENIPLYEEDEGTGRPADEGDDCMWETTGYEGAGTSPASSSDYDSPRSHDAPSSSNGSPPAPADETASARLARTKNDAMYRCIRVTASVYYRAIKDRVPTTEILSEADFLKLWELVWEVTVPFWKTAVGVFIWVMAAAVPSCHNSPPARFIKTLSVVGWMTIGLENWHVAINAANAALGLQRWLRGGFYQQGGMMYDKGPLGGEVVVEKHGFILREASIPEVVANVRCNDDHELIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ21</accession>
    <name>A0A2T4BQ21_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1150033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ21"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="14975" checksum="E380C379CAC3ACDD" modified="2018-07-18" version="1">MLYLGSPSLCSFPRPRSSGPASPRLIFDLKAVTWGRKDRSLHLLGSSVPAAKRRSGLDLNPQAWPFFPLAALYDTSILYFFWSVLPRGGDLFRDCKTWKSNTASKGSRALVQLLQLHRIDIIYHFSSKTCPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ91</accession>
    <name>A0A2T4BQ91_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1406479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ91"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ91"/>
    <dbReference type="OrthoDB" id="5333578at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF2">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015569659" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="231" mass="23998" checksum="8D856E633DF66E42" modified="2018-07-18" version="1">MALKSLLLGLAAVHAVTAHFALVYPEWRADTLAEENEDKYSQWDYPCGGVPYKAGNITNWPLAGGALQLELHHPWTYLFVNLGLGANATNFNISLTPDLVNVTGKGTLCIDKLPVALDAAGADIKEGTLASIQVVTSGESGSALYNCADIRFTKNATGPNNCSTSEGLEMHTIKEDDNDNDNGTDSKDGGASGNSSAPADKKNAAGLMGSDKSVLATVVGLAVAFSLGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQH9</accession>
    <name>A0A2T4BQH9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nep1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1344153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQH9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQH9"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="261" mass="28861" checksum="5910EBBCB6F7B37E" modified="2018-07-18" version="1">MSSPDQRTGVKRPRTQSLPTPSLPQLVAEQKTPIPSTDKDSQRLIVVLSNASLETYKAVQGGVNRAGLNREEKYSLLNSDEHIGVMRKMNRDISDARPDIAHQCLLTLLDSPINKAGRLQIYIHTAKGVLIEVSPSVRIPRTFKRFAGLMVQLLHRLSIRSTTSNEKLLRVIQNPITDHLPPNCRKVTLSFDAPVVRVREYMESLGPKESICVFVGAMAKGADTFADSIVDEKISISNFSLSASVACSKFCHAAEDAWDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQQ5</accession>
    <name>A0A2T4BQQ5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="14" type="ORF">M440DRAFT_1442540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQQ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BQQ5"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="19350" checksum="DFBBC4CC6D1FEA1E" modified="2018-07-18" version="1">MMENLAISDAPPHPPPPPGGAAAQPFAQLPPQMFTTAAQLLDLTDKKLMVVLRDGRKLIGVLRSWDQFANIVLQSTTERIFAPRPDNPQSEYPYGYFADIPHGIFLVRGENVLLLGEIDLDKDDDAPPGYQLAEVDVVKRLAEAKKAADKAKEKARLRKLVKIGFEGENLGDIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQR9</accession>
    <name>A0A2T4BQR9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQR9"/>
    <dbReference type="OrthoDB" id="4961474at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="244" mass="26801" checksum="F3DAB371CF1F584D" modified="2018-07-18" version="1">MPPSSKQPPLPLAPNRAALSNEISLLLSRRTALLKTLNPTSTSSTSTSTSSSSSSKRRAAAPDADAIEQLFSGPRPNQGVGYVPERNNDGDAAASARDQTLRRKLLGKNYKNGKGVGMKKGAESESDEEEGRSALGKRKRPRREEVVRDDDGGREGEAEKADVTTDTVGGQRTEEEEEEERKQEEGHDEVEDEEPKHDAGDDNIDPVKETAAISDNAAGEAKKDKKRKKRQREKQKQKQKREQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQX7</accession>
    <name>A0A2T4BQX7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1343490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQX7"/>
    <dbReference type="OrthoDB" id="4895549at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="10934" checksum="222B39259E2032E6" modified="2018-07-18" version="1" fragment="single">QCLLSLTYSSVDIIYPSLLDTKLGAHANTRFRCDVILCLGFTIASTTLNRTIQKEVQYESLYWERDIALNEMRRISSTLAGLVSTFHMGMCVWQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR58</accession>
    <name>A0A2T4BR58_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1385726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR58"/>
    <dbReference type="STRING" id="983965.A0A2T4BR58"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="234" mass="25167" checksum="E001B97C036D3639" modified="2018-07-18" version="1">MTAKVALIFGYGPRVGAAVASAFAIRGYKVAVVSRSGNAEAANDYLSIKADLSDARNVEGVYAQVKVALGLPSVVVYNALILSPQGFEQPLSSVITDAHVNTFSAYVAAQLAVKGFADLPSDASKTFIYTGNKLNIMTLEPLLSFGMGKSATAHMIHYLAEVYKDSGYKFYYADEREPNGEPAYDKLDAEAHSEYYVKLADESGQGPWHATFVKGKGYVRFDESPVHGGRYPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRM2</accession>
    <name>A0A2T4BRM2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_38581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRM2"/>
    <dbReference type="OrthoDB" id="3559948at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="79" mass="7784" checksum="30991E19D2CF8FF8" modified="2018-07-18" version="1" fragment="single">LSLLLAGLVAAQDFTGQPECAIPCLQDAIPKAGCALTDTACACKPDVQAKLLGLVGPCLLSKCSPGDLAKAQAAAADAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS77</accession>
    <name>A0A2T4BS77_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1395154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS77"/>
    <dbReference type="STRING" id="983965.A0A2T4BS77"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="498" mass="53584" checksum="B43270C2AB88F81E" modified="2018-07-18" version="1">MGSEFPFVLSDPRLGDLDCLVDGESVTAKSGKRFHVIDPGSGKSWASCPDCRQEDVEAAVQSSHRAFQTYSKWTPRQRAQTLLKWHQEIIAARDDLARILVYETGKPLAEAYGEIDYATTFTWWFVGEAERVQGASIVSAIPGRRAVTIKQPIGVAAALVPWNFPIALTLRKASAALAAGCTMIVKPSPETPITALSVARLALKAGFPPGALNVLTTSLEGTPELAETLCLHPLVKKVTFTGSTRVGKIIASLCARNLKKSTMELGGNCPFIIFEDANLDQALGQLMALKWRHAGQACVSSNRVYIQRGVCDKFVELVVSATSQLKMGHGMDEGTTLGPVTTPRSLDRAEDMAKDALAKGAKLVLGTGRRDDSSSGGYFMAPTIMTNVTDDMLMSQDEIFAPLLGLSVFDSEEEVVRRANNTAMGLTSYAFTKNVDRLWRLFESLEAGMVGLNTGNNSSAEAPFGGIKESGSGKESGKDVAIEEFMVTKTGTFTIEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSG4</accession>
    <name>A0A2T4BSG4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme oxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1425752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSG4"/>
    <dbReference type="STRING" id="983965.A0A2T4BSG4"/>
    <dbReference type="OrthoDB" id="10057598at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="80530" checksum="BE1181AA6CF29A04" modified="2018-07-18" version="1">MSFTEIIILLSLLIAFLLVRRWRTWFGRPAKSIIALDTDQESRLEAKLAERVTLYKELYYKVQNLEEFPEILPAAKEMLLELLEHGFSMAKYKPQTRSILDLKEYDPVSLDQFLEAERQEVSDGFESYVRRRSAGSPRELFKTKEDAIQWLKRLAPLNLIDGAWLCRVHKITTPFVLRDITKNAWQVFSEELGDGDVEKNHVLIYRDLLRKHGVNLPACDSIEFIWDHHELNDEQVWRNSIGQLLISLFPNEFLPEILGLNLHFEALAPTGLRATKEFPEVGISAYYFALHVSIDNADSGHSGMALANIVAFMDLMRKTGMMDSAQAWKRIQAGYLLSQSLDDSETPDVFEERLIQILHRKANLARKIHCTSRARIGGKSLSDWFSSPFSASEKGDKWKYGFLHALADSKPWVYRGNSSKSLLMKELSWTGRMFGAFTDSEVELMRTWIDSLPEKDARPGDGYWKTVGGHSILENSFVPSRQDVAVTHPVFGPEDVCPPPSVSPDFVPLPALQVSQTRLDALLPLWFVHPCVLENIVASPYQTAEPLTSKVLQIIRAEMGYSPENTGMAGMDEQLRRGYRPDLIALGCEMARRHNVPEPTCLGDIIGPLSEDSPAAIKFAHSLLNWSMRPQMNGAFLLGLARAFLDLEMWVAADESLLGREARSYLWQVIERKRTGFEACLKELDSDPAKSCEFVGGYDYGRAEIEKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSG6</accession>
    <name>A0A2T4BSG6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1384805</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSG6"/>
    <dbReference type="STRING" id="983965.A0A2T4BSG6"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB72249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="418" mass="46769" checksum="D51C7BD8D06F3FDA" modified="2018-07-18" version="1">MAKQKVCLAYSGGLDTSCILKYLLEEGYEVITFTANIGQEEDFDAVREKALKIGASKVYIEDLRREFIEEQCFPAIQCNAIYENVYLLGTSLARPVTARAQIAIAQKEGCFAVSHGCTGKGNDQIRFELAFYALQPSITVIAPWRDPVFYDKFKGRNDLLDYAKAMDIPVRSTKSKPWSMDENLAHYSYEAGILEDPNTSPPDNMWQLTVDPREAPDQPEDFTVIFEKGLPVKLEYEGGTKVATDSVDLFLAANTIARRNGVGRLDIVENRFIGLKSRGCYETPGLTMLRAAHVDLEGLVLDREVRALRDQFVTFNYAKLLYNGLYFSPERAFLHKSIIASQEDVNGGVRCRAYKGSFSVLGRWSDTAKLYDASESSMDEIGDFSPKDTTGFVSVNAIRLKKYGKAMEDKGQSLAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTR0</accession>
    <name>A0A2T4BTR0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative 5'-nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1362801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTR0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTR0"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000008">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000009">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015456553" description="Putative 5'-nucleotidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="2">
        <location>
            <begin position="368"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="628" mass="70611" checksum="DAA5428BD6719610" modified="2018-07-18" version="1">MLESYLFGALVAAAAVGAAQPGAVKPVAAPMRDLTWGQLNFLHTTDTHAWLSGHFLEPSFSADWGDYISFSQHMRKLADDKGADLLLIDTGDRIEGSGIYDGSVPKGIYQYDIYAQQKVDLLSTGNHELYKAYSVDMEHNTTVPNFKENYIASNLDYIDPKTGKRVPQAQRYRKFKTKNLGLNIVAFGFLFDFTGNANNSIVQPVADTIKEDWFQAAIKEKPDLFVVIGHVGVRMQEFKDIFTAIRKEDWDTPIAFFGGHLHIRDAVSYDSKSLAIASGRYLETIGWMSIDGIAKKQPKEEDGEEAESQKGVSFSRKYIDNNLYGMYYHTGLNESTFPTKEGKKASQMIEDARKALDLDHRYGCAPRDLWMTRAPYPSKDSIYSWLEEEVLPSVIVNEDRKDKARLAILNTGGIRFDIFKGPFTRDDTFTVSPFNSGFRYVADVPYDIAAKVIGILNSQAKIFIHGLPNTRQLTIPQQMYPRPNFDADEIDPIEDGQDDVEFVEAGQEDEEDEVRLELRGVDASRDKGELFGGYTTKDDIGKDGDDTVHKPIDFYAVPNCIQAEVGFSADEKPKAVDLVFIDFLLPWIIPALKFSGGDYSVKDVEPYMEGTLTTKLAEWISDNWKDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTU5</accession>
    <name>A0A2T4BTU5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1080885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTU5"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37958" checksum="E61556B2F0E933B8" modified="2018-07-18" version="1">MLSVRLRAPRLISRGLATMAYATETSPSPSPDLHQPAIIRPSVNEVKHGRLDQRNLEKAVRHIHQDGLVVIEDVVPHNDIDLLNAKMVQDARVLQAMGENGPFNYNQGNLQQNPPPVAEFFFPSIFTNTIATQVTSAVLGPRPRWTFCSANSAMPPLPGASPQRQPVHSDADFTHPTHPFALVVNVPLITMTPENGSTELWLGTHNTDISYQEGAHGERASGRIKEHHLRDRKAVRPSIQPTVKKGSVVLRDLRLWHAGMPNPSEQVRIMLAMIHFAPWYRNPMRLQFGDDVKPVLEELDRRGKLGLDVPVDWISSEEAKKTYLNRVGFGNSYDFNQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTU9</accession>
    <name>A0A2T4BTU9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1082000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTU9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="55" mass="6298" checksum="2970A65DE8CD2381" modified="2018-07-18" version="1">MIYGDDRNCLYNIHDPNFKQIGGLKTSGFRLDAISNERPDNAWTTQPLAKATWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU92</accession>
    <name>A0A2T4BU92_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_154710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU92"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015710214" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16805" checksum="3700B327E1727C2E" modified="2018-07-18" version="1">MTALFCFSIFASLAALCSKKSYSPQDWCPCVLSVCVCVSSALSKPPPGFLSPPPPPPFCPFLRPFFFLKRGLKKNERETVSNRRKAGIVRQTGSLLLYPQESQSSPVWKKRHSSPMGSSRPANRELPFPRKFVRASKTIISTPCHVVYAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUT6</accession>
    <name>A0A2T4BUT6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1340403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUT6"/>
    <dbReference type="STRING" id="983965.A0A2T4BUT6"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="442"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="682" mass="70769" checksum="6A73671F750212B2" modified="2018-07-18" version="1">MDGPFKAAILIVSTTAARDPSADASATVLREVLTQDGGGRWDVVDERIVSDSVLDIQRSIMPWTDGPDAVHLVVTTGGTGFSVADVTPEAVAPMIHKTAPGLVHAMLSASLAITPFAMMSRPTAGVRNRTVIVTLPGSPKGAKENLQAIIKTLPHACLQAAGSNSRALHAGGVKKLEADAGIDRSSSQASAQTPASAPAHHHHHGHSHGHSHGPGQGHGHASLQRFTTPSSTSTAHLSNDISLGPTRRYRESPYPMISVDDALALIAEHTPGPQAETVKVDENIVGLVLAEDVQAKENVPAFRASIVDGYAVVVPKDGKVKGVFPVAGVSHAAPGELPPLKEGEVARITTGAPLPPGATAVIMVEDTTLKTMTDDGKEEKEVEIQADGVTDGANVREVGSDIAQGAVILKQGEQISGVGGEIGLLAAVGAAEARAYRRPVVGILSTGDEIVNHDRPGGLKLGEVRDTNRVTLMAAAREWGFPVVDLGIASDRPGTLEETLRAGLRDADVLVTTGGVSMGELDLLKPTIERALGGTIHFGRVAMKPGKPTTFATVPVKDNAGRRLNKVVFSLPGNPASALVTFHLFVLPSLHKQSGVAPVGLPRVPVTLAHDFGLDPRPEFHRVVVSIGQDGLLTASSTGGQRSSKVGSLRSANALLCLPGGSGKLEKGLRVEALLMSSIRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUW9</accession>
    <name>A0A2T4BUW9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1425070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUW9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUW9"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="93" mass="10459" checksum="67C5484A95FFBDB3" modified="2018-07-18" version="1" fragment="single">GLLRVRPAELPRRVALYKRPVYGRPTRIAAPVSADDVDDDDVDVRAPTLKTWRRWMKVVFAPHVAASGQGIENATEYEVTMTGLRSVKRDKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVE1</accession>
    <name>A0A2T4BVE1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1340796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVE1"/>
    <dbReference type="STRING" id="983965.A0A2T4BVE1"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="219"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="316" mass="33849" checksum="EE9B82CA59CB8C0C" modified="2018-07-18" version="1">MVAAAAIEAPVAGNTLEKKPIKFSNLLLGAGLNMFEVTTLGQPLEVVKTTMAANRGDGFSTALARIWSRGGVLGFYQGLIPWAWIEASTKGAVLLFVASEAEYYARYMGASEFGGGILGGITGGVAQAYATMGFCTCMKTVEITQHKLAAAGVKPPSTFQTFMGIYRQEGIRGINKGVNAVAIRQMTNWGSRFGLSRLAEGWIRSATGKEKSDKLSAGEKVLASALGGGLSAWNQPIEVIRVEMQSKKDDPNRPKKMTVGNTFRYIYSNNGIKGLYRGVTPRIGLGVWQTICMVAVGDMAKTYVEKLTGDKVTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVY7</accession>
    <name>A0A2T4BVY7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_132246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVY7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="94" mass="10576" checksum="E5DE08DDC01B8DA4" modified="2018-07-18" version="1">MEAPRSCQWWSIGMACLCLASDEDQLKLVRWTHDNRKVISSRCRADQGREQSIAAGTLGQGDQRSNCPFPQSMMREHGQLRVICQYAGLPPIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW08</accession>
    <name>A0A2T4BW08_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_365356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW08"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015668787" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7936" checksum="2E0C6C94B7A9F2C7" modified="2018-07-18" version="1">MCNTAWLGMTHMAVLICEVEAVCQTRATNYWFPLLVAKRSLHAWGAGKNMTTSMSKVAGRNLTAAWGMIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW74</accession>
    <name>A0A2T4BW74_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1394100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW74"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="255" mass="27726" checksum="D0B42125992AE80B" modified="2018-07-18" version="1">MSPTVVLVTGANRGIGYEIIKSLIQSPLPYKIFLAARDPSKGETAASSLHPLTANDQTSISVIQLDVSSPSSIQAAAEKVRQEAGRLDILVNNAGIIDQSPDPLLRLRNTLEVNTIGPYAVTQAFKQLLKTQPEGEPNKTKRIIHVSSGLGSIGERLNPEGPWYAIPSPEYRMSKAALNMLAACDAYELRGDGIKVFAYDPEFVATNLVGTPESRRKMGALEPSVSAESCREIIEGKRDAETHKFLSINGKDWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW93</accession>
    <name>A0A2T4BW93_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1361711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW93"/>
    <dbReference type="STRING" id="983965.A0A2T4BW93"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="240" mass="26438" checksum="47D159A4B8A38577" modified="2018-07-18" version="1" fragment="single">MTSSDIPQPGDITKEQFASYLSRYPAVVETISQSKGAKDGQKTLSELDQYRYVDAVETFGLGKQKREMNLDDVKMLVEWKLRHGKFRPTLMSLVSSNPPSSSQTIQFAIRFYANSKDAGSAIRMLSELKGIGPATASLLLSVHDADNVLFFSDEAYYWLCCGGKKESIKYTPKEYLALQTEADALMKRLGVSAMDVEKVAYVLMKQPDMTKKPIADAAAEVKAPAKAATPATSSSSKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWC1</accession>
    <name>A0A2T4BWC1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1404617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWC1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWC1"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="68"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="282" mass="32142" checksum="84B5801CB8890F74" modified="2018-07-18" version="1">MSSKDPAQVLETLRRLQSSTELSIIKLSESISSSTPNDAPQRISDASNTSLDNPSPTSLDADLIHYKELFAKLRFSYVEQVTKEKFIRAIVGDPPLIVTLQENLDLERENAEAKAQLKNLKLEVADLVADLERRGRELSKRYENIQLETARLEELPAKISELERRIKELKSQQESSESDPNLRLPLTKTLGLVSKRKAEQQELARELEALQAKVPRKRKEAERLQAELLPLEAKRQSSTTAAREARRRKEDALGGVADDLEQRARWWRANESMLKQVLDIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWN5</accession>
    <name>A0A2T4BWN5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1360506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWN5"/>
    <dbReference type="STRING" id="983965.A0A2T4BWN5"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="332"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="667" mass="73630" checksum="7DD467EC9C6DD705" modified="2018-07-18" version="1">MAEQTAAPTASPRVTFASGRVADGAASSSDAPDLRILHYNDVYHVDPASAEPVGGLARFMTLCKEYRDGERYRGQPELVTLFSGDAFNPSLESSVTKGAHMVPVLNAIGTQATCVGNHDLDFGVKQFEHLAEKCDFPWLLANILDPALGEDVPLGNAKRTHMVTASNGLKIGLIGLGEREWLATINSLPPNIIYKSASAVAKELVPQLRAQGADIVICLSHMREPNDNKLADQTDGLIDIILGGHDHYYAHSFRNGTHVLRSGTDFKQLTYIEARRKKDDPKRWDFDLWRRDVTSEVPEDKPTAELVHGLTSKLQKSLSKPVGWTAMPLDARFVTARLKESNMGNFVCDIMRSYHNADCSIMAGGTIRGDQIYPPGAIRIKDITTCFPFEDPVVFLRVKGQAIWDALENGVSLYPALEGRFPQVSGIEYEFNPSRPSGARILSVKINGETYEPEKDYTLATRGYMGRGKDGFTSLLVQSEGGQAEEIVDEEAGILISTMLRQYFMALRTVGQWKKLSANWTSIVNDCKHTRLPSQAQSNAEGEGEGEDAVRKDLQQDKGAAVEAEPWRKFLRRRLGYSKKPHNDNDDDHHFDPAATSNSGSDQSGSDSDSQIDLDILLMRKFWGRWARRAGIKAGVCADPLKEAECAVDWTRVIAPVLEGRIKIVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWY1</accession>
    <name>A0A2T4BWY1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1424353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWY1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWY1"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000036">
        <property type="entry name" value="Putative sulfate transporter YPR003C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="617"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="758" mass="82896" checksum="962BEA54004BAE77" modified="2018-07-18" version="1">MSGPPPPLTRADSSKDHRPLQPSTLRQSHTPPSRPGSGDSNSSDAYPSIAAVGESTPLIRDGQSGQHGTFSPRGYSPINGLFSGSTDDGDDDGERESEGQGGFFASLTASDEWKRWLSRRMRTTKMGQSSEIAEQAGFRDTPFMYLAYYIPCLNWIQQYKLSYLKGDFIAAVTMASFYLPMALSLASNLAHVPPINGLYGFIFNPFIYALLGSAPQMVIGPEAAGSLLVGTVVKTSVDNGGEGSEDNDILHAQVCGVVSGMAGAIVLIAGLARLGFLDSVLSRPFLRGFISAIGFVIAVDQLVPELGLADLAEEQGVNHGSSVDKIAFIFNNVGATHKLTFAVAGVSFVVIMIFRELKRRLEKRFPGVAYFPDRFIVVVVSAILCWKLDWENKGVEVLGTVKAASGGVFEFRWPFQLAHMQHIRTAMSTSFLIALLGFFESSVAAKSLGGSSIPGIELSANREMIALGTANLVGGMFMALPAFGGYGRSKVNKTTGAKTPMSSIFLSLLSLLSVLFLLPYFYYLPKPVLSAMISVVAWSLIEEAPHDISFFLRVRGWTELGLMAVIFLSTIFYSLTLGMALGVGISLLMVIKHSTRPRIQILGRVPGTNRFENPESLNSRIEFIEGCLIVKIPEPLTFANTGELKQRLRRLEFYGTSRAHPALPRIRSQDSNRNIIFDIHGVTSMDGSGTQVLEEIVRDYRERGVRVFFSRAPNHRDHLVWKLMDRSGIVELCGERHFVNDVGEALRLTEYEDSVMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWZ2</accession>
    <name>A0A2T4BWZ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1464596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWZ2"/>
    <dbReference type="STRING" id="983965.A0A2T4BWZ2"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17700" checksum="0591F438CB1C8157" modified="2018-07-18" version="1">MVGRGSSAAVEAARTGICKRPLLSEFTSLDRISKGVQGMECKAVADQQDLSLNLAFSTALSPLNMINKLLHGPSFISGAARGKDANQYASEHIRINAICPGYTMTPIMGDVGPEIQHALDEGMHRTAMKRFAQPEELANSITYLSLWMSSFMSGEAMLVDGGFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX62</accession>
    <name>A0A2T4BX62_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1440838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX62"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="60241" checksum="F5CC46970E3F6E5D" modified="2018-07-18" version="1">MAPTQQSTESSEAPTPPRADNVCLSCRRKKKKCDKALPGCLQCKRLHLQCIYEDDESVPVIEEFRQLRKRLKLFEEMLVPGTSRAYNTTTRRVVDISPPDTADAQSMTGCKEDLISRLEALASQVNVGEEVFQLLQSHPGEIYGASQIYFDNIHRWMPIMSKKLFYRRLTNSSRTKRSDFALLLLSIVLSIHCPASGTTQEPLYIAVRSTFWSLNATIDASLEMIQSGVLLSCYEYGFGMYNECYKTISICVRMGQMMGLQDEKPPSDELEYYSDDWIRVAERCNVWWALVIRDRSTLLHDTTLAKPFTNSQDSMPEHLPFEAFDLDPSFSRLGDGVLTRDQAPGTFGYQAKAWRLFDETVAFRRRLANGEILERLGEDRMRIDSQLQSLMGALVDLSGGSTCGYCEPSATVLVSLLLLHKFHPSIPAKTGSISEFGDIPPHCFVASSMAIKTIVRMVVDIAHTINNHYRKISIVSFPPTYCHVIYRATMELIALRNDMDEEEWKSALETLRKATWNYGRRWQAAGNTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX91</accession>
    <name>A0A2T4BX91_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1446525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX91"/>
    <dbReference type="STRING" id="983965.A0A2T4BX91"/>
    <dbReference type="OrthoDB" id="5078320at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="369" mass="40372" checksum="013BE8F3527FB9E0" modified="2018-07-18" version="1">MSQMLRKKEAFTLVTPIPGFIPRQLAIDILHSHSEVIRACKGAVAEEYCAIVVSLPTKPGQHQIHSTGYQGSGDISYSEAASRMVNGRTRTETFPVDIPFTRVEAVQSDVPINRAYLLTLVQEGKLAVLPLTTSSACGELHRLHSDSRPNFLVSSESCGQWTYPSLEMVQRIIKKAELLDAGVLKAMMEDGKLKTVNPNDRSTTPAVAAMSPHSRQPSVNYGIPGQKSPQMPPSYSPAYPHYAYPSPQQSQPPQLYDPRQSMYSPNPQQGQYAPPPIPPKEQMVIMELPGDYPTQYAQPVQGQSLYGSPLPSPGYRPPSASSSDPRWSQGQPSPSLLNPHRMSSGSTSSAGQHHGFVNELSAHPEKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXB1</accession>
    <name>A0A2T4BXB1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1404183</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXB1"/>
    <dbReference type="SMR" id="A0A2T4BXB1"/>
    <dbReference type="STRING" id="983965.A0A2T4BXB1"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015731403" description="Glucanase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="425"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB73979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="461" mass="48098" checksum="833648D88B148BEC" modified="2018-07-18" version="1">MAPSATLPLTTAILALARLVAAQQPGTSTPEVHPKLTTYKCTTSGGCVAQDTSVVLDWNYRWMHDANYNSCTVNGGVNTTLCPDEATCGKNCYIEGVDYAASGVTASGSTLTLNQYMPSSSGGYSSVSPRLYLLGPDGEYVMLKLNGQELSFDVDLSALPCGENGSLYLSQMDENGGANQYNTAGANYGSGYCDAQCPVQTWRNGTLNTSGQGFCCNEMDILEGNSRANALTPHSCTATACDSAGCGFNPYGSGYPNYFGPGDTVDTSKPFTIITQFNTDNGSPSGNLVSITRKYRQNGVDIPSAKPGGDTISSCPSASAYGGLATMGKALSSGMVLIFSIWNDNSQYMNWLDSGSAGPCSSTEGNPSNILANNPGTHVVYSNIRWGDIGSTTNSTGGNPPPPPASSTTFSTTRRSSTTSSSPSCTQTHWGQCGGIGYTGCKTCTSGTTCQYGNDYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXK5</accession>
    <name>A0A2T4BXK5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1361150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXK5"/>
    <dbReference type="OrthoDB" id="4688861at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="262"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="480" mass="54798" checksum="CFA12E77E5FBA07A" modified="2018-07-18" version="1">MSSWKHIPEELRLQVLQTLARDPYSGSRRASLTNYALVCKSWQRIFEKINFQRLVLHQDDLDGVAKLPKRCRPYVTHVCLRIELSEYIPWAGDEPTTFRLPIVRPERMEDIAANSEIIESAIEKLFLGLKTWEKWAKPGHRITLEVSFHSPSDSKYVARSIQAKELDRGLASTSGNSREGALDRIFGGYVHTRFHQQLPPLNMVKRFIMQRHTRRQLTSFTLHQLLSRFTDLEELVFEPWQQFLDTSQDRVDAGYVRLMKGSLPKGLKHLTLFEDHDEEMTNSSLAQGVPARAPNPHVSAALAQRSLTLESLAASFVVDARDFFRLSKREWTWPNLRSLTLTAQHLESTRGSYEINDMLNAAAEAALGMPKLEALEIWNGGPGHAAVFRYSGKKGGARLKWIGTWDLFIDSGVVDAWRMVALKSHGWQMLGLEKHLIESPHDIRSHGDAIQLLKTKERVISPQSLEELRFEAKDGCLCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYL6</accession>
    <name>A0A2T4BYL6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1337759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BYL6"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="638"/>
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        </location>
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            <begin position="815"/>
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        </location>
    </feature>
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        <location>
            <begin position="1125"/>
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        </location>
    </feature>
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            <begin position="1356"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
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            <begin position="443"/>
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    </feature>
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            <begin position="828"/>
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        </location>
    </feature>
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        <location>
            <begin position="1131"/>
            <end position="1149"/>
        </location>
    </feature>
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        <location>
            <begin position="1356"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1369"/>
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        </location>
    </feature>
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        <location>
            <begin position="1422"/>
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        </location>
    </feature>
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        <location>
            <begin position="1460"/>
            <end position="1470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1490" mass="164260" checksum="0E66AB297B27A699" modified="2018-07-18" version="1">MPSKPRRATSKKSKPPEEEAAEFWEITGILAEKTVRKSVKYLVQWQDDPVSGKKFPPEWVSEVTPAAKKEWENIKAERRLQKDQQQAQQQLEQQAEHHADPGPAPGPEIGPKKQKQKQQQQQQQQQQKQQQQQQQKQQQQQQPEQHQQQPEQPQDQKESSSASDSDDSQPPRPAHRRRTNQGQKKRPRSTSLSSASSTGSLARPRKVLRSDTGGSLEPPVSLVSSPSIPSSSEVSELPEAVVSDLPDVVVSDLHDGVTSELSDEVLSKHNSPNRSRSMVVAIPEASNIDRADYQSIFGSQSQSSGNSAQQVAERESQDSLLSIAQSSQAPASQGIESQETVGQGTVPDSQETSDQSWTQAQVDLVPSSRALTDLQPQDSLPDSSSRVIPDSLEDPTTTTTQHSKATQDRQASSSEAPIQESHETGSSDIPSRQPDQLREATDTHSPVLSVSVSHNTPASRATQLLASSSLAEAVPTQSDASPRFLTQPPFLLFLEPPQSSVPSRILESPAHPIAEVVSTIASLSSSASDPGASQAAQIVARDFEPPSQHLAESSSPSESEQIRHQLEAVAVPSQLIASAGLVGHQRATATPPAKQSTPLSSYRRRRMENETPEQAAERHQSTVDAELSHIFRWDDDDDEKAASAHASGQPMSQQMQHDHVPVNENVEHVAPAEERSASHAHTELPMHSTDMHHAVELPSSQGQDHHETAGSGTATAGVVVPEIEGVATLDTAAEPQVPTSQNPVAAELADIFGSAFVGAGLEPPPTTAPEYIHAEQSTVSLADISRQPEPAYRDIPLASFINPEEILMHESFTDTAPSEPVQAEHSPSESSASFSGPPSAVKEHIVTLPYQASLREKYDSIIVAYKNSIKEFNRSFSDEDYSEPDQSLVGRLDELFNSLLNLCDYPGDAVGSDLEKLSPEDQARYCCDANPKFNFLRELLRGIENHLSILIVARSPDLLRLLGHLAWALKIPFSCKATDHVDPSGSDTRIVLALPTEFVDPRKFDVVIGYDHSFRHSSIAQGLSAHSSSSRHPLVLQLVTTHSIEHIDLHLPEDLTLLERKSVLISAIVRARDLVERPDPNHPEPHEIAAQIVEYLSSDEEPFLWEPIPVPENILDVYVHSQSRSQLPTTARHDLETGRKRKHNESGDFENKRARVLSANEVVSSIGTGLPPVSDEVKALLRYATPRADTSRPQVLISVPHTALQVLAEKFSDYEHRLEASNRDAEYKAVITSLEKRVKEYEKTTHRIYETERVALQDRSRFESEKRKIEAAMQSAAAQAEREAEKARKKIAELEATVARLTQDPNASDPQDTPLARSENLLQEAQAKITMLEKRLENAHKEADYIRSTYQDAASRASELQSENNQLRKQNEDLRGKAAENSVRIHEIQERNTAHIYLQQIAELRAQIQSREMELERAREELRQLKNGRRETRQSSVPRSPRMGMMSPRTVARGYGGPSSRGASPAAGASEGMQFYGQQPGNGRWDHLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYN7</accession>
    <name>A0A2T4BYN7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">M440DRAFT_1048138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYN7"/>
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    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="234"/>
            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="348" mass="37331" checksum="58AF9E05CC97AA24" modified="2018-07-18" version="1">MMSFHPQTPQSPSQFSPATSSDPSLGSSGSVVAAGSGTTTLPTPAHSVNGSSSQIEHMMLDDSPHKRKRPLEDVGDDREPKKAHVEDGKLALEDLHLDVGPKYLLLQSPHPESLPRTSEDLYEMFDLTGLAAEVAREKPNGEKNALRKTYKGHIKRLGVTGHFDVQKKKEDSPSDFLAMLQVPDHEWNVHQVKGRALMDGLSEMTRSSLSRALTMAKGPIAKSVWDTSVLGDIGSNGDSSKAPSAKPTAPNTPLISMPGAAMNRPKAQLLPGQNPARPQRSIKKRSYGDSSFEGYGEGFPDDDTGLETGYSTGEGEGGQKRRKKSSGTTPPYPSAMRQSSYGPGMVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYV6</accession>
    <name>A0A2T4BYV6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_117066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYV6"/>
    <dbReference type="STRING" id="983965.A0A2T4BYV6"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057501">
        <property type="entry name" value="DeUb_enz_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25424">
        <property type="entry name" value="PH_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="504"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="814"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="936"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1036" mass="114826" checksum="4841F24A94FF6303" modified="2018-07-18" version="1">MGPERLKRINGSVTKPVDTLSVKQFEPRNEPEVPAAKRQKKDNTRTYGETSHYFEPSRAKKAIHEVLIDDDTIDHRSNSSAGNAGSGILALREYRALDNKVQVGKKSARRRRSRTGSSLTSPLNGAANTRPDVFRSPAFPKRGTLISVQDSPDALGAQEPDAGPANVTSDLFSHFSTKRGRSYLPRPQFKRQKPSTTKEPIDISEDELQAEPTRRGGASSQSSALPRPSGTSGAPAKISMRGDIRPTNFEKSSRCSSAESMSISRAVCGKSIYSRDDSRSAVLLRRGVKEARRLEPVSENGQRLDEYAWLGIDLDQVRHFGTSEDTHYAFVLRSQRGDAGPKLYLEFGDHNGLEAFRGALKSLGAAEKFISELEKKAEKAFTEAKNWIASNATSKTNSRTLASDKEGEDAIPAPSSPDRRSGPNRSKLVDSLMQSAKTSQDSLAAQRPEEELGFEFDLRRLTRSYEPSTRRRMPSPETWTALHPDWHESWQAPLIFPPTGKNRATVDKVDIPRLDEGEFLNDNLINFYIRYLEHRLEKDRPELLRKIYFFSTFFFEKLKSTKGKINYDGVKSWTAKVDLLSYDYIVVPVNENAHWYLAIICNVPNAVKAVPEDKKREASTTPIPDAIEVADAPRSPHLSSVERNLTDISLEDGAAATAAPREKADDVSSCGGIASSVARFAPLKKRKATSSTPSKFDPTQPRIITLDSLGNAHAPTCKALKEYLIEEAKAKKGIDLTTVPSGMTARGIPEQNNYCDCGVFILAYMEEFLANPEEAARKLLMREDLGWDIRPTDIRNSIRELLFDLQAEQQKRHKQLEEEKRLRKAKRKSLVETSPEASSPLKPVTLSPPVPKIPGSFPSESPERKSASETARSSPQSAQEANHREGGGLNGEASDQAAEAQPKRKSSEGPRFVSPLSFDKIVVELKPPKGFDRSEFVTSSDDVQIMKETSVSPSEHKGSSNMTAKRRRRHSSVEEVEAPTVRPAPFSRMQKQGNKSSTNSSSRLPRQSIECIGSDGDQPKYDGIDRSSKPIEAIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYW5</accession>
    <name>A0A2T4BYW5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1393526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYW5"/>
    <dbReference type="STRING" id="983965.A0A2T4BYW5"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="122"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="421" mass="47413" checksum="3E80B2C62C7B2CAB" modified="2018-07-18" version="1">MEWLGRAKIEFTHSPTPRTIKEKDGHETDLLKICESNTPPCHLNPLLFNGHVQTMWTATKPHGPIMYYKRKVFQAEHEAYEGSFAVDFVVKPHEGRDEGLPPRTVHYSDEEFAGIGSDDAKPMLVVLHGLSGGSHEVYLRHTVAPLPDQGWEICVVNSRGCAGSKITSGILYNARATWDVRQTIRWLKKTFPHRPLFGIGFSLGANIITNYCGEEGSDCPLKAAIAVSNPFSLDIASKTMANTLIGKELYLRVLGTAMKSLIERHKKELKQHTKLNLDAIANTTYLYEFDREIQCPTWGYPTESAYYRDASSTDAILAIKIPFLAISATDDPIAVKEAIPFEEFRQNPNTILLTTSLGGHLCWFESGGTRWNTRPVCNFLNHMAYKVDLDSLVPTDYPQKEKAFAASEYDPMRRKMYIVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ76</accession>
    <name>A0A2T4BZ76_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1471204</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ76"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ76"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="129"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB74554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="983" mass="109504" checksum="FAF1475F10121D52" modified="2018-07-18" version="1">MDDLYDEFGNFIGEEVESEAASEAGDQAGDYAYDDEQEEAPSVAGQGLMELDDGPSNAVILHEDKQYYPTAEQVYGADVETRVEEEDAQPLTEPIIAPVEQKKFNVEEADLPPVFFDREFMADLMNFPDQTRNVALAGHLHHGKTAFMDMLVMETHDIADRLDRRVGKKRDEALRYTDVHTLERERGVSIKAAPMSLVLQSTKGKSHLLHIIDTPGHVNFVDEVAAAFRLVDGVCLVVDVVEGVQVNTEQIIKHAVLEDIPLTLIINKMDRLILELKLPPKDAYFKLKHVVEEVNTVIANTVPTKAASRRLSPEKGNVLFACTDMGWCFTLPSFAKMYTDTYGDINADDFARRLWGDVYYNPKKRNFTRKPAEERSARSFVHFVLEPIYKIFTHSISDSPEQLKLVLASLGIELKPSQYKADANVILKLVCEQFFGPSTGFVDMVVKHIPSPSEGAQRLLERYYTGPLDTKVAESMRTCNQDGPLVVHVTKLFNTSDAKSFYSFGRVLSGTARPGAAVRVLGEGYSLDDEEDMTMASIGEVFIAESRYNVPTDGVPAGNMVLLGGIDNSIVKSATIVPPKLQDDEDAFIFKPVTHFTESVLKVAVEPINPSELPKMLDGLRKVQKSYPLISTKVEESGEHIILGTGELYMDCVLHDLRRLYADMDIKVSDPVTRFCETVVETSATKCYAITPNKKNKITMVAEQLEKGISTDIETGAVRIRDPVRKTAKFFEEKHGWDKLAARSIWAFGPDEMGPNILQDDTLPTEVDKKLLSTVKESIRQGFSWATREGPLCEEPIRNTKFKVTDVVLANEAIFRGGGQIIPTSRRACYSSFLMASPRLMEPVYAVSVTGPEDSYMEVYNVLARRRGHVLSDGPVAGTPLYRVNGLIPVIDSFGFETDLRIKTQGGSMVSLVFDSWNIVPGDPLDRDQVTRPLQPASAQATARDFVLKTRRRKGLSEDVSVKTFLEPEFYQSLMESGMLGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZM6</accession>
    <name>A0A2T4BZM6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1440123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZM6"/>
    <dbReference type="STRING" id="983965.A0A2T4BZM6"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015586812" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="144"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="934" mass="101221" checksum="FD705D63D84F6BF5" modified="2018-07-18" version="1">MSSRPLLAALSTLSLLQSAFANPTISYPFNAQLPPVARPNHAFSYSFSPNTFRSDSHMTYSLGDHPNWLSLESESRRLYGTPQEEDIPPGEVVGQEFGLVATDDVGSTTMNATLVISRRPPPSVHIPISQQMDNFGQFSAPSSILSYPSTEFRYTFDPNTFGEGTNLSYYASSNDSTPLPAWIRFNDKTLTFSGRTPAFESLVQPPQKFDFSLVASDIVGFSGTSLSFAIVVGSHKLTVDDPVVIINATRGAKASYDGLTKGIQLDNEAIRPGSLDVSAEDMPSWLTLDPATLRLEGTPRENDDSGNFTIVIRDSFADALSVLVQVDVATGLFQSNLEDIQIEPGKEFNLDLSASFRDPSDIELKVDTSPEVGWLHVDGAKISGTAPKAAKGKFNMSIKAVSKSTGLSETHKLRAEFVIPDESLSTASSSGPKPTGAASAKSEDSRRHRLGTTDVLLATILPVLFITFAIMLLICVMRRRRRQRQTYISASKHRPKISDPIRFTLRNDESDADTIFHLENTVRSKASNARLIRKGDGILSEVASRVSSRSKASGTLRDTSVLRAPPRPLASGARSGTPRSVSPLTDDGDHGSWFTVERATTGGKSHKSSESNQSDTTLPEVAQPYLPTSGFLSEAGENAFRSGLDLTLPSLDDLADLQPMPLAITKPSTQSDGSGTFSATTSSSAALPSSLHLVHEPFSPSLVSRALEPAKGPQKEKQAEGQAAKATELQQPEQARLPSEQWSSQGGSSWLGAESARGPKSFRTEPSFGSNENWRAAPGRRDPSVAYLELVDETPFMPSRTASRITLEERRSLELMSPSKWGEDERKSTIRPMRSTSAISMLSEGDVSVFGEREAPTVPPPQVSRSESPSERNKTSLLVVLLLPSSTPPPRSLFGPRETSQPWAKPSRSPLSKRCVSDAMPPVEWPLFHLLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZR1</accession>
    <name>A0A2T4BZR1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chitin synthase</fullName>
            <ecNumber evidence="2 12">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1337325</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 12"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZR1"/>
    <dbReference type="STRING" id="983965.A0A2T4BZR1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB74812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="899" mass="102018" checksum="717E3241B44024FC" modified="2018-07-18" version="1">MDPRGNPYRSPSPGHPLQQGYQLDDNPYGHHPQNAPMPNIGRLASPSDQLHINPAHSVDTLSYNSQHPSDYSINPEAHHDAYYNAPYEPQPHDPQGYDPHQAYDQPGYDQPGYDQQNYDYDDRRPMLSHQNTDLPLNQVEETRPVTPTGGIKRWKTVKQVLLYRGNLVLDCPVPPVLLRENPHGERDEFTHMRYSAATCDPKDFYDENFTLRQKLFSKPRHTELFIVVTMYNEDDVLFARTMVGVFKNIEYMCNRPNSKTWGKDAWKKIVVCIVSDGRAKINPRTRAVLAGLGVYQEGIAKQQVNGKDVTAHIYEYTTQTHLQLNKDVVSLVHRRQPVQLLFCLKEKNAKKINSHRWFFQAFGRVLDPNICVLIDAGTRPGGSSIYHLWKAFDLEPMCGGACGEIKAMLGTGGKNLINPLVATQNFEYKMSNILDKPLESAFGFISVLPGAFSAYRYVALQNDKNGQGPLEKYFLGETLHGGGKAGLFESNMYLAEDRILCFELVTKRNCHWILQYVKSATGETDVPDTVTELVLQRRRWLNGSFFAAIYAIAHFHDFFRSDHSFFRKMAFFIEFVFNTVNMIFAWFAIGNFFLVFKILTTSLGSDDLLGKTGEILGVVFEWLYGVILITCFVLSLGNRPAGSGKLYSAMVWFWAIIMIYLMFAAIFIAVKAIIADLNDGDGFNISQLFKNQVFYTLIVSVMSTYGIWLIASLLMFDPWHMITSFLQYMLLTPTFTNVLNVYAFCNTHDVSWGTKGDDKVEKLPSVNTKDGQGKTDLPDEGDLNAQYQREVAMFSAKFKEVKRDPTPADLQEKQMDYYRGVRTGVVLIWMITNFALAAVVLSSAGLERITPGTAQDQEAQQAQRSNIYMAVVLWSVAALSSFKFLGAMWFLIVRMFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZX4</accession>
    <name>A0A2T4BZX4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1035009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZX4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="82" mass="9309" checksum="185EC0CB64B3BC64" modified="2018-07-18" version="1">MTQLAAPRLDRSRSRRKRNIPSTHPRSGAVRNAKLGDFLLGKLLRRNRMISFATYAFFCVIIGFLLSPFHCMEGIEPVAFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZY1</accession>
    <name>A0A2T4BZY1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1336674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZY1"/>
    <dbReference type="STRING" id="983965.A0A2T4BZY1"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="392" mass="44313" checksum="752DB35542BF1EE5" modified="2018-07-18" version="1">MTSPCPTSHCFFPSQQAMRTSRYAISRQKACQQCSIAKARCDRKERCCSRCALRHLPCLYPHSNPTTAAASKLFGDSSDSASLPALQPDFFDFSAPDLICPINAEEISNRWLNAYIPFPGQSIKNYPATVSAFIFRLLKSYTGMAVHGRGIPPFVHFSQLMGPRPSPLLSTCLSVIRICDKPLPGSENGTAEVLQREMGNIYERRDTYDHLSMLGAFQAYLIYTMTLFFRLSQGNNPFLRQAMINLQELACMTARQGLMCLAEQQRTRPKWESWVLAEAKRRTLYTMYLFDSVLSSEDGLPTFLGTELEGLPAVSSKTLWLAQTRRDWEAAYNVQLAEWVEGNLRINELWPLPEGLDESQVAKRRHRIDSWLEDLDEFGTMLYAVTSCTHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0T1</accession>
    <name>A0A2T4C0T1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_338533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0T1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="18846" checksum="AC16C8AC07EC6825" modified="2018-07-18" version="1">MAQFSELNAQDFDFQDMDFDIPMDDLESMWVNGPANNNGISLNNNFGFNGQGFTNEQMFVNSNMVANNNWAMTPTLAATPQVVNNNNYAAMAGYMPMDTDLPMSNPMAAPLDMPTANTTMATGQFCKYICLDPGDAAVVNPKIGRGHSQQTWSSTTTWPSTTSFGCHGLRGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0W4</accession>
    <name>A0A2T4C0W4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_339255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0W4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="91" mass="9975" checksum="4860907FEF3A9D0A" modified="2018-07-18" version="1">MYPLRTISCAGSHVLFSGNVAAAVLASDVARVSGKAHHLCCYCSQTGINLPFPFLNLRTRFIFRDREALVLLLCNAGCEELTHHILHCTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0X3</accession>
    <name>A0A2T4C0X3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1402765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0X3"/>
    <dbReference type="STRING" id="983965.A0A2T4C0X3"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="277" mass="30177" checksum="A25E7172D90BAD7F" modified="2018-07-18" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGITALGIKATNGIVLATEKKSSSPLADQSSLSKISHITPNIGTVYSGMGPDYRVLVDRARKVAHTGYKRIYNEYPPTRILVQDVARVMQEATQSAGVRPYGVSMLIAGWDEGIDPEEEETEVKEGEEVKKTKKTGGIHKGGPMLYQVDPTGSYFPWKATAIGKSATKAKTFLEKRYSEELELEDAIHIALLTLKDNIEGEMNGDSIEIGIVGPPADHLLGVEGVEGATGPRFRKLTPQEIEDYLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1A3</accession>
    <name>A0A2T4C1A3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1392779</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1A3"/>
    <dbReference type="STRING" id="983965.A0A2T4C1A3"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015401981" description="chitinase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="30"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="403" mass="41224" checksum="29B7CE8EE7DDE879" modified="2018-07-18" version="1">MFFSKALAAAGLLATAAYAAPTMEKRAAGGKLVVYWGAEDDSTTLANVCADPSYDIVNLAFLSRFFAGGGYPELSLSTLGGPSAAQRAAGATNLQDGTSLIPAIQACQAAGKLVILSMGGAVDFSAVTLSSDSQGQQLADTVWNLFLGGTANPTLRPFGSVKLDGVDLDNETGNPTGYLAMAQRFKSNFAKDTSKKYYLTAAPQCPFPDASEPLNVCQLADYIWVQFYNNGNCNIAQSGFNTAVKNWSKSIGNATLFIGALASGADGDQGYVSASSLLSAYQGVSALNLPNIGGIMLWEAQLAVKNGNFQKTVKAGISSGSTTPPPPPPPSGGCSWAGHCAGASCSSDNDCSDDLTCNGGVCGTAGSTPAPTCSWEGHCLGASCGNDNDCSDPYSCKNGVCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1B5</accession>
    <name>A0A2T4C1B5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_5812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1B5"/>
    <dbReference type="STRING" id="983965.A0A2T4C1B5"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="60" mass="6290" checksum="0A4B7915609FDFDF" modified="2018-07-18" version="1" fragment="single">KSLPDAVTIIEPKEEQAVLQPVSQDYGAKAAQAVAQGSQDIRVAEQEGAAEEAQPAAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1M2</accession>
    <name>A0A2T4C1M2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CLU1</name>
        <name evidence="3" type="synonym">TIF31</name>
        <name evidence="7" type="ORF">M440DRAFT_1402976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C1M2"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="6">
        <location>
            <begin position="334"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="914"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1263"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1272"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1289" mass="141723" checksum="0C2A9CAF300C66CC" modified="2018-07-18" version="1">MAAEAQAAASPSPAHAVDETPDNAMAAPEKAVTEGEADADADAAAEAILNLTIVLPDPEAEKLHIMVSSQEQVHEVRQSIIDLPAAFQYTCFHLEFQGQKINDYIPLAEIPDLGTEPEFRLVPDPYTEKEARIHLVRIRELIGAAGNRSDAAHGILPGLSLYESVTKKVSAETEGSEGQPLAKDYDFQATPSITGLVPEPLEPAPKTVKMLALSSWNPPPCHLQQRGHLLYLVVTTNEGEQFQVTAHVSGFFVNKSSNAKFDPFPRPAPKGQSSHSLLKLIELLSPSFSSSFESLQEYNSKRDPLATFQITNAIPNSPWAVPPPTSSLCTHTPDPTRPQETYLLAGVDNTDTLRDWNEEFQSAKELPKDSVQDRVFRERLTSKLFADYNDAAVKGAVLIAHGDIAPLNPTETRDAQIFVYNNIFYSFGADGVGTFTSEGGDEAARVATGKDVAGVQLVNQLDIDGLFTPATVVVDYLGKRIVGQSIVPGIFKQREPGEHQIDYGAVDGKDVVAIDDRFTAPFSQLSKALKVKPHPVWDKDGKRFDLEASVETKGLMGTDGRKYVLDLYRITPFDIAWREETSAADDQAGAAEYPHRMTVLRPELVESFGRYRMKQWIDAELARRAQPKSGDASAEASTEAKDEASTEEAKDDAKDEAKDEKTEAEKTEVEKTEAEKTEAGEAEKSQPNLSDFKFALNPDAFSGQVPITDEEKAELEADEKEVRAAGEYLRDRVIPELLRELVDSDISFPMDGQSLGRILHKRGINIRYLGKITSLATNDRLRCLREICIQDMVARAFKHVAANYLRSLPMPFAPSCLSHLLNCLLGHRFNAKPTADVDQTFRELYPEADLSFESVTPETLRTEIEQQVSRRFRYQLGAEWYNEVRPVQLLRDICIRVGVQVVAKDYAFESGAAAPTPAAAPASTAQPEQVNGQANSETKSKKKKKAARESSPATPPVSAPTTTFTPDDVINVVPVVKHSCPRSSLAEEALEAGRISILQNQKKLGQELLLESLSLHEQIYGILHPEVAKVYNSLSMLYYQLDDKEVAVELARKAIIVSERTGGVDSAETLLNYLNLSLFLHQIGDSKSALGYSIHALKLWKIIYGPGHPDSITTLNNAAVMLQGVKAYHESRLWFEESLRVCDSVFGRQSINSATLLFQLAQALALDHDSKAAVNRMRESYNIFLAELGPEDKNTKEAENWLEQLTQNAVSIAKHAKDVQARRLRSGIRFPVATAAQSAGAAPQRGAASQIDSRSIDELLKFIEGTDASKTGSKKRPGRGNPKRRGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1M3</accession>
    <name>A0A2T4C1M3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <ecNumber evidence="10">1.13.11.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1392872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="10"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1M3"/>
    <dbReference type="STRING" id="983965.A0A2T4C1M3"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB75471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="148" mass="17131" checksum="ABD2CB5195F3FB0B" modified="2018-07-18" version="1">MPPRRSLLEQRKTGTCLIAELNDMLCGALLSAETESGVLETVADTINGHCLSKAYQHLHEDEEIRYIRGGQGYFDVRNKGDEWVRIQLEKDDLIILPAGIFHRFTTDESNYVHAMRLFKDEPKWTPLNRAPELDSNTYRKEYVSQYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1N7</accession>
    <name>A0A2T4C1N7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_342572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1N7"/>
    <dbReference type="STRING" id="983965.A0A2T4C1N7"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="672" mass="75086" checksum="612EEFAF3D43E32C" modified="2018-07-18" version="1">MSERSPSCVACARRKVKCDRLKPCSSCGKSGAACIYRAPVPLQRHRRRLTQGDLLSKIQELESILDSHGITFEALGNSWIRSHWEDKLVGGPQTTQTIPEATASVKTTSVEAEVPSASQEEESSHPDVLLASGEQACAAWLWSSLPEVLKTPPISQLKQHGENEDGETFKRTEATVTTPSLLLSPYPLSTAPEQLELHPDPKHVFKLWQAFADNVNPLTKVIHAPTLQRKILEAAWTVESVAKPLEATMFAVYALAIASMKPATCIDAFRETKSMLLSRYRTGALRALSGTNLFSARDLEVLQALTLVMMIDTQSEFTITAVAVAMRIAHKLGLHRAAGDTRTPFFDQEMQVRLWWYIRGLNSRVRRGMGLLSTIDDLGDARLPMNVNDADLHPLMEKPPAVQHTAATEMVYCLMKYDLWNFVRKSSSFSGDLNPRERAAQLITSTSAENMAKKRSVLGEVDRMLQERYLVHLDQSIPLHQLSAALAGLTIHNQRFLMFHPRHQPEGGRYMSPADQDLVFESSVRLLELNRQVRSTNFSINLVDHMACRTQVDALVYMISELRQRTSGPLVETAWDLITEVYGQPSLMPPCDDDFFTALAGLTLQAWDARYEALDRLSVVPPFIETLQAGRNQAETADGPAAEMEALQTVRMGDLVQNEPLDWTYWTDLLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1V0</accession>
    <name>A0A2T4C1V0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dopa 4,5-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1439243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1V0"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21440" checksum="38F9095C9E0F9C3B" modified="2018-07-18" version="1">MTQVTIPAALKPQEDLQTVVESRTREWHFHIYFLLQSPAETAAALALRDAVLRLRRDGAFVAVPLHRVNKQPIGPHPAGSYEIWVPDSSFSDVYFYLATNRQNLSILVHPLTSQQRRDHESRNAWLGTPWPIYLDGLPRESSDVPLQYPQLGLGWSSAAEDEISLDERRKRGARVEALLANDAEAAPAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1V6</accession>
    <name>A0A2T4C1V6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1439288</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1V6"/>
    <dbReference type="STRING" id="983965.A0A2T4C1V6"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="322" mass="35082" checksum="66552B82A8E03EC6" modified="2018-07-18" version="1">MSHTEHIHHAEGDIKICRDKPPIKDQQVIVEVVVSEERTTAWYKFRKAMREPFSEFFGVLILVLFGDGSIAQVVLGQGAKGDWQNINWGWALGLMLGVYCAGASGAHLNPAVTLANCVFRKFPWNKLPVYILAQLLGAMIASLIVYGNYKSAIDVYEGGQGIRTVGLSTSTAGIFCTYPAPFLTKAGQFFDEFTGSAILLFCLYALQDDGNIGAGNLLPLGLFFVFYGIGACFGSNTGYAVNPARDLGPRIMTSAVGYGHQVWTAGDYYFWVPIIAPFLGCLFGGFLYDTFIFTGDSPINLPYMGLTRGLGNRTKTGKPIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3H0</accession>
    <name>A0A2T4C3H0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1246114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3H0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="149" mass="16669" checksum="83FFA8227129FAAC" modified="2018-07-18" version="1">MRDGRALIPEYRSGQGPKPRPPGHNAQGDAGRCAVGRLRFHGKEMNPFSAAESMLYARRYMTRISPQIASATTHIVAFSRMRLSRLFNTPPLSARKLIYPCPLSNPRSSRRPITIPSASSSPTERARNRNVNRKTTARPPARSTRYRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3T9</accession>
    <name>A0A2T4C3T9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1401666</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3T9"/>
    <dbReference type="STRING" id="983965.A0A2T4C3T9"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="415" mass="46265" checksum="6E9E7C8B2A5444BD" modified="2018-07-18" version="1">MSSKRVCLAYSGGLDTSVILAWLIEQGYTVVAFLADVGQNEDWDAVKAKAEKIGAERMIIQDLQQELVEELVWPAVQCNAIYEDAYLLGTSLARPVIARAMMKVAKQYNCEFLSHGCTGKGNDQVRFELAWKALDQKTKTIIPWRIPEFCERFAGRQALLDFAESKGVPVTSTKAKPFSMDANLIHCSYEAGLLEQPELEPPADMWTMTVDPMKAPDEPTKFTIHFEKGIPIKLEVGDKVITGSLEIFKAANEIGRANGVGRVDIVESRFIGLKSRGCYDTPGLTILRTAHRDLEGLVMDSKVRFIRDQMVTANWSACLYNGMYFSPEREFLHNSIVFSQRHVEGKVNMVAYKGNAFVVGRSSETSNLYSETESSMDTLEGFSPMDTSGFIAIQAIRLEKYGARKIRDGEPLAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4R2</accession>
    <name>A0A2T4C4R2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1333217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4R2"/>
    <dbReference type="STRING" id="983965.A0A2T4C4R2"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="63" mass="7064" checksum="7561A16395098D47" modified="2018-07-18" version="1">MGQHYRADVEDGAVGFIRALWRSARMCHWVEPSAEAKGHGKGVLFFRNRNGLGTKPMVLPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C524</accession>
    <name>A0A2T4C524_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_4176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C524"/>
    <dbReference type="STRING" id="983965.A0A2T4C524"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="13570" checksum="F30920A704F2B281" modified="2018-07-18" version="1">MSLEDIHGVTVRGLLDQLKAIGFANLTSYNINELFPHHVGHYIGLDVHDCPGYSRREVLKRGHCVTVEPGVYVPDDERWPKHFRGMGVRIEDSICVDEDAPYILTTEAVKEVVDIEALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C581</accession>
    <name>A0A2T4C581_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1233698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C581"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="19040" checksum="7CBE03FD99C8F3CE" modified="2018-07-18" version="1">MYHVEERRLVCAADLNWPIRAQDAAWQAGQAACRKPLQIHTWTGRHWATIRLAWLWYQPGLVVLGLRITNQDWQCLRRGGSNGPAWRSTADALPTASVYTQNFLLWIRRPERRQNTPACETMVAEVSRLTCGLTPPRWGFLCWHGFQDLSPAWVSLKCVQYHGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5D1</accession>
    <name>A0A2T4C5D1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1354908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5D1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5D1"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="37574" checksum="ADF589E1F45A22C2" modified="2018-07-18" version="1">MPAESTQPIKALADFVPNQRKNLPIALTTEDVKGKTYIVTGATGGIGYELAKHLVRLEAARVIIGARNEERGKAAKATIEGAAGRKDVVEIWPLDLASYDSVKAFGKRIETAERIDALVLNAGVSHAGWQVKEGNEAHVTVNFISNCLLAFMALPHMQAVAKTHGITPRLVVVGSMGAFFAGESIKKFPAKGILDDLNDRAKWESDFTNRYSVSKLLQHMVARQLASLRPVSDLGVVVNVVDPGYCKTGLNKELSLWTRAKAWLAKVTLGRAPEMGSRTLLHAIKVGEESHGKYLTSCEIREDHIPEWVTNEAGQAVQKQIWDELLGKLDKIEPGLPSRVIADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5J8</accession>
    <name>A0A2T4C5J8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1235294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5J8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="18030" checksum="85C6195A09FB1FF8" modified="2018-07-18" version="1">MSYPYRTAHSKVVAWVDVMPKGAHAQRILNARHCRLTLFVPGPDPSCVISYSQQYLIQHPRTTVSTRYGLRNERLAGRQQLHSRTTVLQPERAIESARRTPVERLERGLERDVMTALGAACKGDAEKLCRVVSMSWQGLNTKRTCGNSVSHEEPTCQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6I3</accession>
    <name>A0A2T4C6I3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1917-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6I3"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="301" mass="34211" checksum="57EEB379BAC5DBFE" modified="2018-07-18" version="1">MDSEDSDFYGDDETVSHLLQRVADFDVDEWRQQQRVHPGRPQRQTDFLEEASRLHNPYEGIPYAWQLTETLDAFLARLPPATTDQTPEVPWIFICNPYIPRVHKREGQGQLSKGNEDEAPEEEGSETATVAEGGLERLHLVSKFIEGMHRSGQPPSVVEREINRERKQAMSDILELAHLVKVRTGKWMLFCPATEVNEVWEIVAKATANNELGIAAKVAPRSPLEDPRKDRLLCVYTADFEDKADVGRVLQKLRELKLVEARGRPIYYKPDAFTYIGISHGNPWGLRASIYSSTDKFPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6K3</accession>
    <name>A0A2T4C6K3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1329847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6K3"/>
    <dbReference type="STRING" id="983965.A0A2T4C6K3"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="3">
        <location>
            <begin position="71"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="5">
        <location>
            <begin position="207"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="456"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="563"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="765"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="883"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="140755" checksum="299E79AE70D0BEE6" modified="2018-07-18" version="1">MSANPRLRPGFPATQVAAHRRRLRDDDDPPPASFSTGLSSNRPAAKLAVAQESAAPRGPGPQPVIPLTLLDGPQQRLYAFAVYILLWAWKLYDWIGVVEDGDASWWLFLKWILIDFAFLFGLPELRIPWLELSQLVVTGVFASHLVTNYMLMFNIPLPWQTWLLGVAKVLYDREISVAEHHVKVSELLNNHSLIMGKQVINILPEGSAVLNPEHMPFCLSPKTQTAAALPIFFNSTVPAEIEFLRLDLDTGKEEIVKVPTREVNKLAKTVRDHNADPDAPPFHWTYHVKKPGVYRLNKVLDEYKLEVQRPVRDTYVVPCPQAKIRTTDPSDRCIRDLSNLSLDVVGTPPLKIKYSRTINGKNHAFHFQSLQPEGFNSPLLSTSGLGIDNGDDVDWVKPHKVTVKLNESMATTGEWEYSVEEVYDAFGNVNKYADVYEDPDSPKMKGLAQRFTVKERPKIRLQGCDLRNPIKVARGRAAKLPISFGLAGPVDDTSHKVTWIFSPIDSITNSGDHGDQVSVGTHFAKSSLDKPLVSEPGLYTLKSVSSGTCEGEVDEPSSCLLLNPLEPHLSLRTEEIPDKCAGNSVGLRVDLDLVGTPPFTVRYDIISDGRVEKQAHRVDGLRSQIELVPRKAGRYKYIFRSIDDDVYTGLPLTGSDKVLEQVVKPAASAYISNPEKTINACLESEVDVDVMLAGDPPFSLEWEIIHDGKRKPGRAENIYDSHFKIQTAALSKGGEYILALSSVQDQRKCRTFLQDQLKISVRRQRPRGAFGLIEQKNSIMAVEGTAIRLPLRLQGEAPWTVSYRNLDASPDIITRTINGPNDHLMVRSRGTYELVDVVDKQCPGVVEPKASKFQVDWFPRPELSIVPSNSITPAASGVFVKQEVCEGDIDGFEVRMKGSAPYHLEYEVKHKPLQGAASLSQRRFDAALSKAAVAMDTSKAGDYTYKFSALADNLYNSDKHFSPLVVQQRVNAKPSAAFTKPGQAFKYCVEEQEHEDTIPITLTGIPPFYVEVEIKHQVGSPAETYRIPSIQTNNFGMAVPRQHLRLGNQQLLIRTVRDARGCQRKYDMGGPSIQVQLYDAPSIYPLESRQDYCVGERIAYTLSGTPPFDIAYDFNGQWHARSHTTSFRRIAEKPGEFIITSVSDKSSECRAAVNIPRTIHPLPSVQISRGKHSRVDIHEGNEVDILFEFWGTPPFEFTYTRSSNAKKGQRSIILETRHDVSYEHSKVVKASQEGTYEVVAIKDKYCSFSTQQVELKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6L4</accession>
    <name>A0A2T4C6L4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1374173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6L4"/>
    <dbReference type="STRING" id="983965.A0A2T4C6L4"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="192"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="403" mass="45116" checksum="35C6E6DAD85DA807" modified="2018-07-18" version="1">MAFEASRAPAPLVAMPVSFAMPSGDRQPEPVQPEAIQSSEEYMQHLRSLVHVRTDLQKSGYVVQQLSQDDLNRKRRCGRCGRHLPYRMKRLMWLQKTPVQGKDEDNDRLGEPIDNSVQGDASKKGREAALQCRHHPGRVIRKKWTCCDGTPGSPPCRAFQEHTPKIYAAGELEREWRFYHTPYDCTGGSPAVAVVMDCEMGTAITGESELIRVSAVDYFSGKVLLDKLVYPDVKMLHYNTRYSGVTRQDMEDARRARTCLFGRASARRALWGFIDPDTIVIGHGANSDLTCLRWIPPVIIDTHLVEKANRPPEETKQTTQEDKAQVGDLQLRSDGANAQQAPSENAPAAPKQKGGLSLKALAKERLGREIQIKGQGHDSVQDSIATRDVLHWNVCQMLQQRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6V9</accession>
    <name>A0A2T4C6V9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NGG1p interacting factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1421068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6V9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6V9"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="33321" checksum="DED87400B0A82067" modified="2018-07-18" version="1">MAEYLDGVGAWGAWQVEPSKFTQLVVDSMRTLYPEELADRKWDNVGLLVGNSESDAKKLQPVVMVTNDLTFQVAVDAIGQGVSVIVSYHPFIFSGFKSVTNDDPQQATLLQLAKAGIAVYCPHTAVDAAPKGLNTWLANIVAGPHKNTQSVAIPCASAPESHSPAGYGTIGRFTNGAAVPLAEIIKRLALKLGGLKHIMIASPVGADIRTTVVRSFGVCAGSGYDVLKSADVDLLVTGETSHHSALRAIQQGRTLIQVFHSNSERGYLREVLRPSLEKLLREGQPDAEVILSEYDSDPFKILDVSTLQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C753</accession>
    <name>A0A2T4C753_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1421180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C753"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="226" mass="25215" checksum="50AB1525A3CA6687" modified="2018-07-18" version="1">MANYEIKIISDTVCPFCYLARARIDRAITLFKKTVPGASSSTYTIRWHAFQLDKTLPQGQSTPVQDIAVQRFGADRLAAKRARMAQLGEQEGFRFTFAGRIGNTRDSHRVAHLGRELGGWEMEDRVQREVMAMFFEGGGDITSWEDLSDAAERAGIERGVAMRWLEDGSGGDEVDEEVEEMERLGMKGVPKIVIDGEFVVEGADDVTAIFEQLYKAKEAKGAKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C792</accession>
    <name>A0A2T4C792_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_361228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C792"/>
    <dbReference type="STRING" id="983965.A0A2T4C792"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF16">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="676" mass="73510" checksum="23178CAC45D895AD" modified="2018-07-18" version="1">MASATQIQLLDSSTPSLVLRIKPDDGSDASTTKEAVQLAGLCRVALNDLATYMDRVLQPSRGYTADEILDLPLDKHRIADILHDLPSRRSTRHDLAVAVASLLHPVHEGSLTAIIRYDADRVRLRAWASLQRRYDLLQATRRNGRMARGMTGGAEPGVQAPAWASRITRQGPWDPAKKPISLAGAVALPMPVQVAQEAELAPFFEHLSSGGSHEIEGVEGAVELHDGNGEPYYSVRGAEFRKGVVYEDGRMDLCKMVVGPDHIGRLMDSLRTNMHVRHFLLGNNIIGPAGVEAIARFIAEFPDRMDTWYLAGNCIQGGESFKTLVDALVESPAVSNIWLKRNPLGRDAAGDVYRLITETKNLSTLDLDQTELGDRGVAELFTRLASFSPSDGGKLPLRHIYVNGVGISTEGAAAVGKFLTSPHSGVTSLYMSCNPLGNEGAQALAAALPKAPYLARLSLQSVGVSTQGAVALCEALTGHPGLKYLDLGQAYATEDLGQAYNYIEDEAVPAMAQLLRGTPQLQYFNLGHCAITPPGLIKLTPAILETSSLLYYFATSILADTSKKPVAFIPSIDTAFPHPDAPSTEQIKSEKAIREHLEANVRAAFGEGMSYTDFLAEEKRWLVSDRVVRKIDSVYRNRDAGLARRRLLTLVKDWQEGDDTLQRVMDARGAPSCSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7E0</accession>
    <name>A0A2T4C7E0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1390792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7E0"/>
    <dbReference type="STRING" id="983965.A0A2T4C7E0"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015443171" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="95313" checksum="137EA9E0F3E69A26" modified="2018-07-18" version="1">MRYHILFGSALGMILVAGPVQAGPLPRLGPRLLKVERAETAVFDTSAIPDGPGSTQPAVPNVPTGTTPRPVFQTLTGTTADIPDSLRSSIPTQAQSQAPVSTSAAPSVVPVETSSTSIPSVPEVPSSSVLDTHTSAAVTASSTTTEANAVPTSAARATSSEPAVPTSVSSEPSVPATSSMFTTVVIPDLNAPTTEPAKTTTDGISVTSTVPEPESSNPTTSDIPAATTSTTVAAPVTTHSTTVESIQTSVASSSAPTETAVQTTATSAATTGAVRTETEASSAPTVNTRTDRATVTDGVTGSTTVSLATGTTASSATGTSAATGSSAATGPSATGTSTLTGTSTATESSAIPETLAATSTSAATETSAVTSTVPAAAVPTTAPETQTTAPGSSTGLPTSLTQTQTQTNIVNQTQSSSTATSQASSTSQTQPPSTVAAIFSTSSIPVPADTVTVSSSLIQPPQSTSASLASTGGSSLTSASTQAGTTLVTSVSTTSAALPASSSSTEGAASSSSPTAATTTTTTTTNSATPSTTTTTSEAVFLTSSAPIEPTPSSTASSASSSSTAQASTSSQAPPAPTTAPETTQSASLTKPVFLPTPTESSDGTTATTTTTTAEATSTTLRTTTSTATVTVQPTGTPDLAVPTTLTFFPTATTTVPAQVYASNLATAQRYNDVFKTMDPKSACTGAQAACIDGQLATCGADGAFVLETCDPGTRCFALPMNNTAGVLLGCHDPALAESILGGGAGLPQSSNSEPAATPVAPTSVPAGPPAVTTNPGVTVTSYITVSDLPPPAASTTTVVVAPSPQPPAAAPPAASPPAVSHPVASPPPATSSPAAPASPSASPPLSPPVAPTPTTFQTIRTSAPPPSITPPSDNNNPFAPLPRPNPTSLILIPVPDDPLLGPSVLAVPSDRPTEVLTAAAAALPTVTVTEREKETVTVTQKDRETVTVARETVTVTQIPPTETVTVTVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Y6</accession>
    <name>A0A2T4C7Y6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_289835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Y6"/>
    <dbReference type="STRING" id="983965.A0A2T4C7Y6"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="325" mass="34994" checksum="EA9540F099B3C071" modified="2018-07-18" version="1">MNTSTVKSRFLSHPEDLGIVTVGFSGGQPKAGVDAGPTALIESGLLTQIQEELGYKLYGDEKVETYKDLTPASDPDYRGMKNPLLVSAVTRKIASQTYEHSSKGRLTLTLGGDHSIAIGTIAGTAKATRERLGREIGVIWVDAHADINTPETSGSGNIHGMPVAFLTGIAKEEKEEYFGWIEGDMRLNVKKLVYIGLRDVDAGEKRILREHGIKAFSMFDIDHHGIGRVMELALDHLGDDTPIHLSFDVDALDPMWAPSTGTPVRGGLTLREGDYICEVVHQTGNLVAIDMVEVNPSLAATEAGAQETVRAGCSLVRCALGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Z4</accession>
    <name>A0A2T4C7Z4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_287524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Z4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="14581" checksum="C7F934A4948E2AC4" modified="2018-07-18" version="1">MMGRQPLHMSPRNPRRCCRHWGTAAETRHWTPLNLNGDAEHSVRRLASQTRSVRSGSRTRLFVLGQAALPGGAANLDAHQSAQKGGVGQSKRSIGAYGPSGKMWTAAVRDGRLDLDLDFLLAQDIVRPSTRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Z7</accession>
    <name>A0A2T4C7Z7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1330350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Z7"/>
    <dbReference type="STRING" id="983965.A0A2T4C7Z7"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="301" mass="34327" checksum="A78668908B054709" modified="2018-07-18" version="1">MLEYTDFQKVFPPGAQMPYDRKRIHEIEARRKELGGQLFIDRVLKALGITKNKVYPPKNDNGVRQLHQQICESSMSMHHKLSLLYYILLDYDTVDGQVSISETFASTSSMPQNYEIFMKGLWYMDGLEFSTALEFVAHPSLISDFADDIIIALVEHAVDGDYDLALAYFHTVQPVLKTSRALELIFGAIAQTNVTEALMYSRTHPEHTREQLFRQMVAETLGNKSDQADELAFLPFDSVEEAWFEEYLSTGDGRNLKKAKDTLLVRKIASDRFGEIRTQRTSSQWGPVLEGIKMGIEGQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C844</accession>
    <name>A0A2T4C844_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1400647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C844"/>
    <dbReference type="STRING" id="983965.A0A2T4C844"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF4">
        <property type="entry name" value="IMPACT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="503" mass="54380" checksum="22445C7ABF788C64" modified="2018-07-18" version="1">MAGHGDLQEMLRMLTARKASMMAAMGYIKALQAKNLKSIDQIAEAPLSTVEAAISDAKLAKSFHTACKSHGKKSNKRPAEEPAATAERKKPRLEMHKRDLDYNSMAPEELEASLALPLCEDEYLIRETTLVTNRAPLVLAFAVELLRFTMPEQPPSSRLSLAQAVVSANSRSKAVSIGIEKAPASGETQIPTGQPKVSVLGREIPVLKRGGYTWSDENQQSPTSAEAANPSSSTPASTTSNSVWATSKTLTSKGSVFVAHAASITAPSMRSGLMKVLFNQYPELEKTADHVAWATRTSFGGSSLVQEASFDDGEAGCGKFMLELLRASNITNTIVVLARWYGGVMLGPDRWRLMRECLNDALSAQQRTSTFSGEALWGLDAEDKKPSMSTIGMAIHRPEGARNYLLKSFASAGASEGGGGKKTTAALNDERQENLGRLLGALRLLFASWAPVLGRAELDRRAWSWYVAVRPDIEAGPSGWGEKGTLKLSKILDLRRKEGDVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8A2</accession>
    <name>A0A2T4C8A2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1400692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8A2"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26457" checksum="FF2790120E481498" modified="2018-07-18" version="1">MRFLSTTMGPDRQALGPQMQVIAAGLPRCATSSLQAALESPHLGYFPCMHMAHVMPSNERAKIVIEAMQESDKEKRQALLHGIFDGYKASADFPGFWFIEDLMDMYPDAKLILNQRKGGDESWLQSWSNSLAFFRTRTYLLLCLPVKNDRLHWQMHQIAKKQIGERWHTKDLDGFYDAYQKFVLEEAKKRNREVLTWTAEDGWEPLCKFLGKDVPKEEPFPWSTTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C963</accession>
    <name>A0A2T4C963_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1420269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C963"/>
    <dbReference type="STRING" id="983965.A0A2T4C963"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="131"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="824"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="983"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1235" mass="133592" checksum="DF8D9132961A35EB" modified="2018-07-18" version="1">MAPWLSMPTMHTSGRRSCDSTRSSHHDAFSCFRRESRNPSMASANGRHISASTQVAVGSCPALEVQQTVERSARQGCVIRARTTRCGNQSSSNDSRSSNRLSNRGRIFAWAARPAWLVLTLLALVLVATPAAAVQFEFDNCLPDSYRLHKPPLLQWEPLYVDAVFDTKTPNHNLQVIVWGNVTGSQNLSPLPPPNDPYWTNPDDTNGKIEQTPYSDTLATTLVSRVNVLTYEPWNDRSDFCAASLVNGTCPLAPTFGNVDLPYGLPSVNLSHDFFSSYAFSSFAVTFLVINGDPAATNIGCVSATITPDLGSISWVLKFMPLLVLLFAGFAVPFAGIWSPWGTTNVFHWTANYGRDADLLRLVTPGFSDCLQYIQFIVLTGALTLDYPGYFQPVVSQVGWSSLMFNESFVAHADPWQNVEDGIYVTKAGTVYGLQKMAQLIGMSEAEDVWPGMMVWLCVIIASVIVLIQLGFALQWILRKIRRTTEEDLRAKNIPFVIGNVVRIVFNFMLIPIVALSCFQFVVSGQSPGWTVALAALTLAVVIGFAAYLLWLIIITRPKSVLFDDLPTVLRYGPLYNTYADEVAAFALIPILLNVIRGVAIGAVQPSGVAQVVLLAICEVIQIIMIYAFRPYQKATSMNIYHSLFAGLRLIIIILMVTFVPSLGVTEGPKGWIGYAILLLHACVLALGFFLGAVQTIIEVIARLFGAGGDDVTGLTRGGLSKIFGMRQLSRRVNHRQGPSRASQLSTAAMLDAEDSGKSGFVMPSGRVRSGSVASLSGVMAHHRHRSSSALDSMYSAAQRNVDTASSYVPGTPGEASTFSFLASPSAARQGPPGVVVEASDPYYRPPRRRREMTGDSSQLESRRDSLTIEPVAQAGGLAPEAPDSGAEISRGATPAPGHGGNNLSISFPANRPDYSTREVDFYYGVRGPALNSEGPGRKLGTGPADPTGPAATAAGWLRSLLFGGKTKDKGKGFEVVRSARMPPNMVRNGGFGDETPPEGIPVAMGVVRNGPIDSDDDDEPQVRRPKRREGELLDNNGDPQSESDNGEPDSPVTDRLPRGRMSQSAVALSSKKAEASHDGVDIEGVSDEDMSDPDHDAPVIPRKSSKRHSAVLDRTPQITPLVRIDSHTRRPDSRASQQTAQTESTLQQGGVSLLPRLPFERTGSDRRSDQRPSSKSSLDFPDLRSIDSATQDDPAGFGTVSHHSISRIDPQTVDDDMLSTAASVVDDAHSAKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9Z9</accession>
    <name>A0A2T4C9Z9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterol-binding-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_360462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9Z9"/>
    <dbReference type="STRING" id="983965.A0A2T4C9Z9"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="13436" checksum="3B7E158D2174EEB5" modified="2018-07-18" version="1">MSLKNDAFPSSEAFDAINAALSSSEADRKDAIKNGKAVFAFTLKNKAGETASWHIDLKETGTVGTGLGENPTVTLSLSDEDFGKLVSGKAQAQRLFMSGKLKVKGDVMKATKMEPILKKAQTKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA02</accession>
    <name>A0A2T4CA02_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1399497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA02"/>
    <dbReference type="STRING" id="983965.A0A2T4CA02"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000065">
        <property type="entry name" value="PX domain protein (AFU_orthologue AFUA_2G07450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="180"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="567"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="118957" checksum="23D462B924CD13E0" modified="2018-07-18" version="1">MSSIAADLAQRRDDSELASVESPSRAGPGGNDVAPEDYASSKTDGHHASKSPECDFKSLGPADTSAAQSPSQESSLASQAIQFFASASPATLAGLGVGISAVTYAVLGRIGLVLIGAFGGVVSFIIWESKNPELAKTLRGEDGPRVLDRVWADLTAVRALEKQDDDDEESSRVRGFDDFRPETREALSGLVDSIVHNYINWWYTPLVPSDHAFPLSCRKTITSYLLAISNRMCRKRPADAFLDLLTNSTSMIIVFLSELATAFSELPPDTNMSAADTIYNYLAENPDSRLANLLNKRQQATKFKMVSEDLLAFLDKSAYNCDPARIFLREILANSVLEQTLQQCSRAEWINGWIVYLLEAGEPNLNQAIDVGMQTGRDVANNVFADLDGNVGNIGIAKPRRGSNDQGQARRKESTHKKKLSKADEELEEAMEEMKRMNAMIAEEDERRKRASTLTEASERSKQSMDLMTGGDGEAQKSGNTAEALSPTSNRYSPRGASVDGVSSKSDTIYTPHTPRSTDSASQASSPKENKDQTFTSFDQIVPQGQHQQESDEEAPRKEPLTLHNASFTLHDDGSGDTGKIKSKPNTDYLIQVEPSSSHYPGWMIVRRYSDFETLHEILRRIAAVSGATAFMELHKELPSWKIHTKESLRGELERYLRDACWYQALAESEGMKRFLEKSQGHTHGNSKSFGWETMGKNMLEVLSIGPKGAMEGGKSLVGGVSGVFGNLAGLSRKSTAQSSVDSGGGPNANRLSISSNPANRVESIARSPARSERASLDSQRSSVIATQPGRVAPMERMLSFTSPNSSETDLRLGSRGRLDSISTSVSARPSMEHSRTSSLAALRSPSSISLDFTKLPPPPDEISDDYEMSGHDFDPKARRKDGSIMENPSRNNSSQALTGSASAPALSGKKTQAQAPAAQTPAKPARQYTQLSEAETRVAVELIFAVINEMYTLSSAWNIRRTLLAAAKSFLLRPGNPSLLTVQNLIQSSVIDANTSDAGIATLLRKVRENTMPTEQEQALWPAEPTEEEKKQLAVKARKLLIQSGVPAALMGVMGQSATGEALGRVFDCLQIEEIARGLIFGLILQAVRILTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAC5</accession>
    <name>A0A2T4CAC5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1437391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAC5"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000010">
        <property type="entry name" value="Fungal transcriptional regulatory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="752" mass="82895" checksum="4A0084C42A6889F2" modified="2018-07-18" version="1">MTAPLAQPTVAVAAKDTAATIRKRRRRAPAGGATDDCFTCSKRNVKCDRRRPYCSQCLEIGNECSGYKTQLTWGVGVASRGKLRGLSLPIAKAPPVTREPKKSPVSRARAQSIPAYDYLSISHHHSHAPSLSQSSWGSVGYAPSLVHSPDGTPRYARYPLHLNTDTLSSSCESVASEVDYLSPMSQSYAREEIPFHHSPTVLYEGYPTQHSSPIAQSPPTVLVLDHCRAPTSYPGLVYAPSEAHHALSHHHMDPYESHLGHKLMRGCESLIGAKSALLAKMPFFMDYFRITMAPSMVFIDGPHNPFREHVLRLARDSPSVQHAICALSACNLRMKRRLSLGYGTSELLATLMAEKQATEATSGSELEDKSLSDEIQHRNMAVHLLNQQLGDPSRSCHDSALATILLLCHYRMVESGIAKFHTQFAGVRKILAMRKSRGSTSSKNSTWMEALFTYFDAISASINEREAQLAPGFEGVSPDVQDLPTGSENMIGCDRTLFKTIGKLGRLNLLSQHRPVQGMSEPIHSRQNADGRTETSSTPRPGEGDLATKFDDDEMLASAMYSSISFDECQYLFWREWRAARQELQDWRFDATSVAMSLPGSPTAGQVRDLGAVSEAFRYAALLYSERLANPQEPSTHINFQNLVSQVIHHATSLETSSAAEKFLLWPLFVAGSECIVESQQSIIRDKCRGIMSRSGYMNNLAALAVLERLWSGDVESEAKLCYYDAAETAKGPFNWTKCLGGPGAGVEWIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAG0</accession>
    <name>A0A2T4CAG0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1320659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAG0"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="108" mass="11812" checksum="B4C03F908CDAE73C" modified="2018-07-18" version="1" fragment="single">MSSWYSNLVTKTSSQISNLRSTLLSSEADGDTEDDTHVCRVLRNYYTEKGRPFPGWLPPDPKAPPPQMTQAVYAHYSGPGPAPAGSAQDRLKQRLWGTRTTSPSSSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAR4</accession>
    <name>A0A2T4CAR4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_267333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAR4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16179" checksum="18114AB40065E331" modified="2018-07-18" version="1">MCCWQLDLWVYRTLAAGSITHDCIIHRRLRIQGPHPVRGTGRLDTCSHTLADTIGHDSFLGQGNPGCVARRAEIRANASRLYPAEKPQEFGDCMLTYMHTITGTLCKSPHVRRLLVSSAGIGRAALPDAIGTPSRHGPNRNVVWARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBW8</accession>
    <name>A0A2T4CBW8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1349452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBW8"/>
    <dbReference type="STRING" id="983965.A0A2T4CBW8"/>
    <dbReference type="OrthoDB" id="4940520at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="418" mass="46342" checksum="03371A1530EA8529" modified="2018-07-18" version="1">MRNFSLPKPQPAISLVTEIQFGIKLEFRAPPVATSHPWPGSDRGRSLYYFALALQRSGLQAAFLLDKDEEAKDEGEDATLGNDTTRKDTDNEIEDAPDARDSQTTQIPGKFIVKTKHNPDMFIMNPQSSTPWVNAGAKDNPLLRYWLLKAGIENKTEVQRLGVHLNWHPMELSSPMLRESEANNLFPGINTAIYEMWTAHPAKLNTHSACGLHIEVGPAVVPSLGIIASLSQGLTQSFQRQDRGTTNRQVQAPRPTLTTLQAQRVATLVVVLEDKLLFHLCHPSRRRVYHQLSSASGLAHAPNAPPCPLAEANLPPNVLTGSGPVEKAIKHLWTATAIDQVQQLLSLHPRTRDKSRTTALHITAHAHEDDGVTHAIEFRHAQAVFSQSFVDNWTRLVLTVCKAAFLPVERFKLLVAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCC3</accession>
    <name>A0A2T4CCC3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1326355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCC3"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46488" checksum="5806DF9A9A7FF0E7" modified="2018-07-18" version="1">MASALEFKPLAALRSLQSGKGPLSLDALPAVLRPLVRAYLLGYASAVAPRLLTLMLQFISKRRKSKKKYLSADRDERSFKDSAFRILRTGLDPRRFPTFCAALVGGSTMLQEPLLKIISRVATQLSATSQLRLARWLSTFISGWLSLQLLQSKQPKQSKQSKRSKGSKDLPRSYNKWITSAASVDLRLIEALRRCRNGELVYGKETGQAPLLGSMCDDYGLPAEWGDPAKTIPFPCDIVHMGCGSSCEYHALSRFFRAWKWSMLTYLPLALALQLRKPKQMNLMKAINGSTRSSTFLATFITLFYYGVCLARTRLGPSILGKDTQARQLIDGGLCVGSGCSLCGWSVLIETAGRRKDMALFVAPRALATLVPRRYPLEKQWREKLIFAASTAVVFTCALENPKRVRGVLGGLLGMVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD27</accession>
    <name>A0A2T4CD27_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1350194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD27"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="423" mass="46840" checksum="24E3C2C21968ED09" modified="2018-07-18" version="1">MPFKQHNRQYDLVVFGATGYTGRLAAEYITANFPVNVKWAIAGRSESKLQAVAEDCKKLNPDRNPPAIETASVDNFEQMSALANKTFVLITTVGPYSARGEHAVKACAEAGTHYFDVTGESPWTYRMIKKYEKTAKESGAILIPQIGLESAPADLCTWALATTLRKQMNVKTRDVTISIHNIRAAPSGGTVSTLLTLFDHFTVSELAESGKPFAHSPVPHPNEPKRPRGSVWQKVLGVHHVPNLGTVTTAFTNPADQTVVERSWGLLSEIPSRKDEFYGPNFHWEECHRVRNWFHGVIIHLVIVIGVLLVATGSPVRAVLRRIVPEPGTGPSRDEMEKEEVEWRGIANPDTEMPTNKQAFCRAWYKGSMYALTAMFCCEGARTVLEDDLGLEGGFYTPCCLGQGLIDRAHDGGFKMETRIQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDL6</accession>
    <name>A0A2T4CDL6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CwfJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1350551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDL6"/>
    <dbReference type="STRING" id="983965.A0A2T4CDL6"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="300"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="484"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59498" checksum="DB156FF25D034AF3" modified="2018-07-18" version="1">MAAPKIIVLGSLNGQLEPAFKKLATLHAKNQFSLAILAGDVFTTDTDDETISALLAGSIEIPLPTYFTVGIHPLPPRIAARIEADEEICPNLHYLGKRSVTKTSEGVRIVTLGGVLDPNLVAGQSQEQHLPFHTAGDAKALRGANSTDILLTAMWPAKVWTGSKVVLEPSQQALVKSSEEIADLCATLKPRYHISASPDAFLYEREPFVQQSDKDPNVICATRFISMAPYGNDKKAKAMYAFTLNPTDTTVPPGATASPFTARTTAAKRGRQDEGYSRFGNHHDGHHGRHKRRRASPPPGPDRCYFCLSNPNISAHMCCSIGDEAYITTAKGPLPTSTTFADRGLDFPGHFIIIPLPHAPTIASMGSTADPASEAVKAYNEMSRFKESLQAMIAARSSHKLGAVTWEISRDRNVHLIWQLVAVPADMIQKGLAEAAFRVEAENLKYPAFSAADLPLEDLATAGDFFRVWLWADNGEDMIKGKSLVMPLAQDARFDLQFARRVLAKLLGLESRLSWQDCAQSVEEETRDAEVFREAFKEWDFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDL7</accession>
    <name>A0A2T4CDL7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1419975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDL7"/>
    <dbReference type="STRING" id="983965.A0A2T4CDL7"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="169" mass="18995" checksum="BCF7D1AC01D63C22" modified="2018-07-18" version="1" fragment="single">MERSKPQAFLSSYAPRLRTYNNSLLTPVLPSAPTGPVSRTTKRGTTIINYAEDGYDDLDDDSDDPRRRPTGLRSLRKEDSVSRQDLADKVGKEIKEPVEVQGIWRDWMGKSRSVRSDQQNAAQAHLPLTLIPIRIDLDIPSFIPPAPFPAPNPNSVDISLPQYRPQEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDQ2</accession>
    <name>A0A2T4CDQ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1371823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDQ2"/>
    <dbReference type="STRING" id="983965.A0A2T4CDQ2"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="50626" checksum="15519C46BFD94F50" modified="2018-07-18" version="1">MDDAMANHVDGDAFMSPTSLSPFDEYAANPRYIELQEELRGLLFAGSLDFSRVSIPKMRLVKYLKNWVTECSPYLDKFDEARHFGIQVPLMAQSSPGLFYAVLAFSARQMERKACLDSSHDSLELYQESIRLLAPGLQAKDPNMLVTACILAVLELMSGSPRNWRRHIEGCAALFAFYEVTGFSGGLLQAVFWCYARMELCGAIISGGAESTVLTLDRWVPPVPDGFGTTPAHAEDFVKSIFYQKGRETPDMHANWAVYLCAKACHLMYRQVRLVELGEPDDADDRPFAERWRRLWAELQFWRDTRPKCLLPIMTTEAGDNQIFPIILYAHWAAISSNQLYHTASIIMLEMRPPGEALPNTLEYSAIWHAQRVCGISWTNPHRGNLINAIQPLYVAGRLLTHPREHLEVARIFKIIDRTTGWGAIWRLKDLEAEWGYESGEILSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEB9</accession>
    <name>A0A2T4CEB9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEB9"/>
    <dbReference type="STRING" id="983965.A0A2T4CEB9"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="261" mass="29156" checksum="AC94604F0A34723F" modified="2018-07-18" version="1">MGSQVKVGKESKLFEPLTIGNGKITLKHRVVLAPLTRNRGTPLRETSTAENPNRIWLPNDVMAEYYAQRATDGGLLISEGIPPSLEGNAMPGVPGIFLEEQARGWKKVVDAVHAKGAFIYAQLWHSGRANIPQLTGTPIVAPSSIPWDDPNECFMYPAPHSTTPVKYSEQLPLELTVDHIRKTIRDYCAAAKTATNSWGVLESGRYDALLYGRYFISNPDLVERLRNGWPLAAYDRSRFYGPFEDPTIGYTDYPTYEEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CET1</accession>
    <name>A0A2T4CET1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1110868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CET1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015706457" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13983" checksum="27FE217A2C0F6302" modified="2018-07-18" version="1">MKFCHCLHVVRLCAIGTLAKSNSYFVSPFSIFPHTRALSLSALFSSSPGDPQPRSGKRNPCCHLMSKFGGSIARPHASMSFLTSPKPAKRDPSGKPLTSCRWHLTAVGGVQVAISIAWQRLCRIFKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEX8</accession>
    <name>A0A2T4CEX8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEX8"/>
    <dbReference type="STRING" id="983965.A0A2T4CEX8"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="4">
        <location>
            <begin position="476"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="698" mass="77439" checksum="B7B10A4F7BF53D43" modified="2018-07-18" version="1">MVRVQKLTPEVLLSEPKRGPAVPNRDGTHALYTVSTHILGGKTNQEFRIHHIETGNSTKLSSDAGVHDALWIPSTKLDIIYLQSAENGRTQVRVASAVDASAEHYLAAEIDAPVSDLKLRALDNGSVAFVVTALVCESALYNQEAAQRGSTARVYDAEVPIWNASCRPNRCSLWYNELALRNGRWELQGELLNLVDDIDLEAPSLTYTDAPCNDFDICRNGIAFVSRNLRERGPDGSPAMSVYFVRLDSFSLPPEGMPRQIFIPTTFEPASITNVRFTPDSSSIGFLYTAHEDPYNTRLFLASIHSLDAFDVFSLVTCIEDEEDNPPTAFEFAGSSDSVILQSHQLGHQVLSHLTLYDGAKPETFFTGSSCSAFYPLREGDWSILLTTSSSFVDSSLWQIVDVSEANILRTISSATKSGAKFDLSFNMVTELWYEGANGCFIHCWMIRPQGFDENKQYPWVLMPQGGPAMAWNNEWSTTNNFAAWAAQGYVVVLPNISGSSGYGLEFTKRIHSQSGDKPFQDLLSLITYLEGVPYLDESRSTVVGSSSAAYLLNRLLGLDVAKKFCCAVYQSGTIEPPVSLSRKEPAFESFDQLNSMYQHAGLDTYESDMGRSTFFYGWKDAPPTLIIHGEKDKQCSITEALTAFNLLQTQGVPSRLLTFPDESNVTTKPENTLMWYDVVWDWVKKCSDGNIDRGYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFD4</accession>
    <name>A0A2T4CFD4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab family GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1324181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFD4"/>
    <dbReference type="STRING" id="983965.A0A2T4CFD4"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="57"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="597"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="756" mass="83561" checksum="59EE6BB652B8D24B" modified="2018-07-18" version="1">MAKLRKMVRGPTPAALRYSMLPPPPMTDLEFYAALVKDYQQTAARLPTLLSNKIRKGIPPPLRGVVWQSMSGARDASLEEQYERLNGESSPYEGLIGKDLGRSFPGVEMFRDPDGDGQRMLGRVLKTFSLYDTKIGYCQGLAFLVGPLLMHMPDKQAFCVLVRLMDRYDLRSCFLPDLSGLHVRIYQFRELLRANLPLLSSHLEDLQVETAYVSQWFLSFFATTCPLPMLFRIYDVVFAEGASETLMRVALSLMRRNEARLLSCTELEDVMQLLLSRGLWDCYHYNADEFVHDFGSLTGIVTREKLAQLEQGYRESLVATANTARTSDIATAAARFLGRIWASSGAFPRSSGLVPGLSAPSRPLSMLRRSTSKQSLASTLNSVEASSMSDDSGSRESTPVGPKAAAAAVTGSKNTEDRYLHSQIEDLLMALSELQRNHALLSNELKREREEREEDRKAVRSLLDGLRKRASRGEEAASSASRDGAEDATEKADEGEELLDRVESRFTTDDEHDESKKKDKPSSSPPGDRSQLQLELDQTRDQLASAMSQNQDFNRRIHDLDQEMSSLKEQLRESHSHVRALHQDKQRLEKQIQVLRARPASGEPFGGRDSGTDWSGKANGGGGLREFKLGRSKSMATQGGTYNRRKSSLLHSNDLVPPPPASMPATPAASNDSKTSTNDLDTLLLDLVQAKTAQAIAKQEAEEAKQQLEALKKAYGVVMGDASNASLPPGTVNVKVVQPAATTTSPGTGGFWGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFP7</accession>
    <name>A0A2T4CFP7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_193185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFP7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="88" mass="10079" checksum="2560946C7F4BE683" modified="2018-07-18" version="1">MKGRKSLRWLTAPQEPHLSCLRNTNHLSFFFSSFFFFPFFWCCLSLSMSLLIEPRILNEHARSQSGSGTCPHGALPSRCQVVASPYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFY3</accession>
    <name>A0A2T4CFY3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF427-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFY3"/>
    <dbReference type="STRING" id="983965.A0A2T4CFY3"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF5">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="107" mass="11855" checksum="41DD7AB5B826E8A7" modified="2018-07-18" version="1">MVGKSITPRTGHATARVNGTVVAEATSWRETEGNVYFPPESVNRDVLRGSGLSTWCPWKGDASYYTLEVDGQKLENAAWYYKEPLEGALDLKDHVAFYKTKVEVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH11</accession>
    <name>A0A2T4CH11_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1398165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH11"/>
    <dbReference type="STRING" id="983965.A0A2T4CH11"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="23"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="533" mass="59199" checksum="695F38C646EDED4A" modified="2018-07-18" version="1">MTDILAQQTPLTLLGPSDKEKKYDRQLRLWAAEGQAALESANILLINSGPGTAGIETLKNLVLPGIGKFTIADNLTVQDEDLGVNFFLDESCLGKPRAQCCTELLLELNPEVEGVWTSGVADRPSLQKLLDSPQVFTMVMYSLPIHPEMLEAIEAYGRQHRTPLVAIHSVGFYSYFRVTLPGTFPIVDTHPDETATTDLRLLAPWPELSQFAKEMTKDIDNLDHHDHGHIPMVVILLHYLDIWKQQHDGAYPLSYSEKTAFRQMVSDAMRRDNPEGGEENFEEAVAAVMKHVNPPQVPSSLKEVFDYEHKDEQQAKSSFWIIAEAMKQFYAEHQRLPVAGGLPDMKAESSVYIKLQNIYKEKARQDANDVLARVRQIPGGENIDLVEVELFCKNARFIKLINTITETPPSLDQIIERELSNDEIAAIAGPEMPFSLISIYLALSVLSNDPIASADEITAAVCAMAPALKGNERLTQVAQELSRAAGGELHNISAVTGGMVAQEVIKIITKQYVPIDNTCIFDGIESRCQVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHI0</accession>
    <name>A0A2T4CHI0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalase</fullName>
            <ecNumber evidence="8">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1434929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="8"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHI0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHI0"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="9">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="741" mass="85110" checksum="A14BDE74BE2BC1A7" modified="2018-07-18" version="1">MQGTSNHRARGSDDYGVYDDAKTYYASEERHSNRYGVRTRTYSQNSLVKQLERMGASEPFRRGSHDESTMDQGRRFLVNVDATLEILKNQEDTDGNMQITIEDNGPKVISLRTAASAGHNRFEVRGTYMLSNLLQELTLAKEYGRKQIILDEGRLNENPVDRLSRLIRDHFWDGLTRRIDASSIEVAARDPKDWTDDPRPRIYVPLGAPEQYEYYQKVAADRPELRLDVQQLPENITVELIRDLNDKPGLLAVAVEKVEEDDGKGNKTTTLKGLPFVVPGGRFNELYGWDSYMESLGLLIHERVDLAKSMVLNFCFCIEHYGKILNATRSYYLARSQPPFLTDMALRVYEKIKHEPDSKEFLRRAILAAIKEYHSVWTSEPRLDPVTGLSRYRPDGLGVPPETEATHFVHILEPYIKKHKMEFKEFVRAYNYGEIKEPELDEYFLHDRAVRESGHDTSYRLEGVCANLATIDLNSLLFKYETDIGRTIRSLFGDKLIIPAEFCAGTPYQPGESVSSAAWDRRAKRRKLTMDKLMWNEEEGMFFDYDTVKKQRCTYETATTFWALWAGLASPKQAADMVKKGLPKLEMFGGLVAGTEKSRGELGLERPNRQWDYPYGWAPQQMLAWTGLLRYSFTEEAERLAYKWLFMITKAFVDFNGVVVEKYDVTRPIDPHRVDAEYGNQGLDFKGVAKEGFGWVNASYVYGLQIVNAHMRRALGTLTPYETFVKAIELNNERAMANLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI16</accession>
    <name>A0A2T4CI16_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_78266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI16"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015548572" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7595" checksum="32C1B088B4460F88" modified="2018-07-18" version="1">MHLFFGHRVFSLFWIFFLFFLPSHSSYKASFLITALERFPAPPFPRLGVENCWTYVRPPILPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIL5</accession>
    <name>A0A2T4CIL5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1466910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIL5"/>
    <dbReference type="STRING" id="983965.A0A2T4CIL5"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF13">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="250"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="713" mass="80198" checksum="B8097ED076E544A7" modified="2018-07-18" version="1">MGNCFSTRQRRCGICYFELDEECAALVEPPVHRSYTWRKESGIHDEERSEPPDEQLPYPLPEAWREFLRVGIKAKLGIFQASRGRGCRGCESIVKAIESACADDGVFLDGKSWEEDVQIAWEVPSGRDRELSNLKMVLTANVSKRDAPDRGSEEYHLWTILIDVDWAGGTTKEENYHPFAYKSPVPFNNTGSETSFRRISEWLDECNSLHRSCMSDSAAQLPKRVLEMTPDAKNNIKVRLVQDVGGQERYACLSHRWGASTHLCRTTVESLPSHLEEIPWGLLPKTFQHAAEVSVWLGIKYLWIDSLCIIQDSAEDWKEQAAQMCEIYNGGYVTFAAAWSADSDVGLFRESPSFTVNFPANVGKQDASYLIRRVPEHTTWDVAGVLKMTPELPLLSRAWVYQERLLSPRIVYFTRYEVAFECAGSSRDKICECEHVPGGIWGGGSNGAGAGRGDYTDFRKLYHSEALAASNLAEIRKHWHQIVAEYSGLRISFTSDRLPALAGVARQYGTAHSADLGRYVAGTWENCFPSELLWYRATLKVHDRPDTYCGPTWSWISTGNIAAYATGCPRMYPDELEVVSIDFKLNGPDRYASISDAVMDVRGYLAPGTLIEVHNPLSDTKSIRFEGVAGNSLSFHYDYPVDKPGPKHIPFGSRISCMKTGFVWGGKHICMLLHRTNLAEDTYERIGLATEVGRADLDSWFVDSKDKKTIRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIZ2</accession>
    <name>A0A2T4CIZ2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SMAD/FHA protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_86799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIZ2"/>
    <dbReference type="STRING" id="983965.A0A2T4CIZ2"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="198"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="289"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="636"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="678" mass="75098" checksum="53FF05A4B6A5F232" modified="2018-07-18" version="1">MAHRTEKSQLKRPRGSLPEDETDTKKPRRSDRLAQVDPDKTPVSREHHLPSPVTNNATDGSTELPKEHTATPPVAAADELTPRNAPEGLAQSQALSSPPQDTQPLSQFIDRHPALSDEVVDEQKEGVWGYLVPLDPKYGDKPLVLKKRVACPIPNDVEAVSDGTVQSKSKSKSKESKPVKDEEIYEKTKVKGVAAGGYLIGRHPECDVVVSEGVVSNRHCLIFAENVGTDTVAVVEDVSSNGTYVNEALVGRNQRRELQDQDEIAVHGKARFVFRYPQSRQTSAFSQQYTLLDKLGKGHFAEVYLCVEKSTGKRYAVKIFTQHPGKDNRSKTEGLQQEIGVLMGVSHPNVLCLKDTFTERDHVYLVLELAPEGELFNYIVRKQKLSEDETRKLFRQLFQGVKYLHDRNIVHRDIKPENILLVDQDLHVKLADFGLAKIIGEESFTTTLCGTPSYVAPEILADGKHRKYTKAVDIWSLGVVLYICLCGFPPFSDELYSRDFPFTLSQQIKSGRFDYPSPYWDSVGDPALDLIDSMLIVDPERRFTVDQCLKHPWLNANAPAVNDSTGGLVDGIGGLEVNRRAPVRERTLLASLNSVSIAAEIDGGNKGAPIKVFSKNKHKAKAPQEAGPAHHRAPEEFMEMGGKGDQQLFDDDTGSIYPSADIAAKQKAADKPNGKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJJ4</accession>
    <name>A0A2T4CJJ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1467134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJJ4"/>
    <dbReference type="OrthoDB" id="4898550at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24213" checksum="09ED3DEB8AFAC1DB" modified="2018-07-18" version="1">MSEAINQARCHCGKTFKSPAAMGQHLRDSPNHPPENNVPPPAPKERTGCSCGRNFKSGSALQQHRRDSPRHAREALKVQAGEIATASQETCANEPKENIVRPSDSAAEQLKATRDKKNKGDGKQASQPSHHTDLEDQGERTYEAASSSYTWYPGVGDDISLCCDRCGWCGHCAGGTSRFATIFNLSLRIELQGDNTLLPTGRYPHVQIQVNGGVISNVEETST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJL7</accession>
    <name>A0A2T4CJL7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1396904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJL7"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015468078" description="DUF7580 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="3">
        <location>
            <begin position="331"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="580" mass="65047" checksum="056101BA4F46CF2C" modified="2018-07-18" version="1">MAEAVGLALSILPIVIWALEKYSEPLDAYTDHHRAVGTLQANLQIQRMHLEATLQSIGLRHPTPRELADALRQRFPVNHGEIAFIVRQMDEMMLGMMEGLQVDMSRKPLWTHEPPERASWEWRRVKRSFRTKKCDKMIRDLRSWNDDLRHLVQSASQTLPPDEGNYAIQRVRRLYNGGNCESVRTTLRSLHRALREGLVGDGAGGHQVCIELNSLHAGGFPLLTFRIGVLHEGGGMMESGSWKLFYAAGEAAQHNPTVDTQPYSLQSRPSTLPSRRSSYSQSLREKAHSIWSKSRDSFKQLPTPRASVEDTSTPSIPPLPLKPITSIPPPITNLCNALSHPSHTEEVFGSLKDPTSSSSSETFFSLSHLSRNHDTIIREISLDKILATEPQRIAPAIQPLSAKRRYGIAASLAWAVLYLADSPWLSHTLDRHRVKLFLQRKQATGLISLSEKAYLSSPLSQPTSLPSPASSSASLRQTTPAMTPKKLIFDLGILLIELAVNQSFSKESLSAILQHDYRPLKNYLDLVEQEAGIYYFNAAQRCVYGVFLADQGQMDFDLDQFQHEFYSTVVAPLQATYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJM6</accession>
    <name>A0A2T4CJM6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJM6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="118" mass="13511" checksum="BBF741643596598A" modified="2018-07-18" version="1">MASSEEETRTPGQDGRSEKLQQRERTKALVRQRSSMANRRGANGKQNHKRARRRGGPNGESRRRSWIGRASKSRNAQNGEVEVGREKQLEEKIEVARGREADENEKVVKKHPRVVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJR9</accession>
    <name>A0A2T4CJR9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1435501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJR9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJR9"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="143"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="24054" checksum="EE4D70F4BE8F731F" modified="2018-07-18" version="1">MAKNRKDPTKIKLRQPDRSPPKEKTLLDIAQERSLFDQAARRERELAGKSGDGEEDEDDGKLSPGAERFLDALLWTTTLAILHSTFDVLVMNQYGTVIKWDKIVANAGRAWCAFLFLFYVLHPHEANQTLLPGLPQRFQRPLRQLLFFAMSCAAGCALVYITNSKGYLYNMKRAPPLGCLWVWAVVELDLLWAVPSLLVTGVYLWVNGFSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJV7</accession>
    <name>A0A2T4CJV7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import translocase, subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_44389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJV7"/>
    <dbReference type="STRING" id="983965.A0A2T4CJV7"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16414" checksum="BF12C501FFDE4BF8" modified="2018-07-18" version="1">MVTLTEVEDEHFQHAHAVEIEDDDFTDTESEISNESDFDPTEETLAERLYALRDIIPPTTRGWVSSRVNAVAGAAWSALSFGGKSAWVITTSALFLGVPFALSFAEDQQLTAMEQEYNMRQTGSELLTAGAEPSTAEQVGAALGSEQAKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP67</accession>
    <name>A0A2T4BP67_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1442925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP67"/>
    <dbReference type="STRING" id="983965.A0A2T4BP67"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="313"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="747"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="455"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120636" checksum="EAA90A7C9690468B" modified="2018-07-18" version="1">MGKKKRGHPDVEEILSRPWCYYCAYPSLFVCPIYIASILISLTVVLSLGERDFEDLKLLISHQKAKHFKCDRCGRRLNTAGGLSVHLNQVHKETLSQVENALPNRQGLEVEIFGMEGIPQEVLEQHRNRIIQNFYQAQEDRRIATGNPPPGQSKNPRKKIKIETAEELRKRFAEYRAQRKAGVAYNQPGFTGQQPAYGYPADNLSARPPANLVGAPGLPQRPSQPGFWGGTAQATATGDEIDQLIRMAEAGVKPQKRPDEEEAAEGTKTKKEKDKKGRMVYDDAEFSPEEKMAALPRYAYIPPVGAVGVRDCINISQKDRNADVNEPHTMATLSIIDLAGSERASVTKNRGERLTEGANINKSLLALGGCINALCDPKGKTHVPYRNSKLTRLLKFSLGGNCKTVMIVCVSPSSAHYDETQNTLRYANRAKNIQTKVTRNVFNVNRHVKDFLIKIDEQMALINELRAQQRESENVSFAKFRKQHEKRDAIARGALERLRAAYDNADEERQERITTMRRLKHFERRISLLSAWIAAFETVANQREGEEEMPQSLAAIRQTAQGILVELENSRHHVRHKLEKSAWERHLDTALAHGVRQLELAEGNDTGEIASLTREAELLKSNFNREVYREVLEQEKACDAPMMQMLLTAQFEMIASLNAVMLMDEDSAIAHAKEVIARLLQTGLTAASQVVKPDGSLPAVPDIPAPTPRRTLRKRKSLSAYRPVVPPATVAVQNEHVYASPMKSLPKRRKALGMPKKGVSFTPVKRTTKSRGVRWRDDETEDGTLEDFEKTPQQLFSSPRAEQPSPVVKSKIPSPPQFNSVAKGDAANNDDSLELSDAPSLSIAKPGRFQAGFLSRGSRLSSGSSGLPVSSSPPALSMHLRSSSSPDVTRTPPLRSLQGPKTDNMSPLAYSKVPRPSPPYHQLQAVMDENNPPNASESDSESSTIDMDKLRNAIASKKPRRMSLAGQSSVPVARRVASIAPPAVERPASRSNMPVLASATNGISRLRRGSLERRKSPPLLCSPPDFKSDDLTAGQARRMNMGAPMRLDSHGATQRDGVGPGGPHRVTISVGTAGAAAGVAAHRRLDSRGGLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPB2</accession>
    <name>A0A2T4BPB2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1344900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPB2"/>
    <dbReference type="STRING" id="983965.A0A2T4BPB2"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="613" mass="68013" checksum="955ECFC958F39D78" modified="2018-07-18" version="1">MGREPTSASCHTCRRRRIKCDLTRPSCGQCQRSGYECAGYERVLRIQSHGIGRSSLVKIGQSSSFPSEPPDQDGEKDGGHSSRGSSSICRGKPDVKSRPSLTQATPPLISQPSLDPLVDNVTFSYFFDAYSWINIHSILLQDTPMRQHLTQQTDELGYDSLRALAYGLFGRDHQVGSLQQKGARLYGTILKRLQSRLGVASKSELATLIKPISILGSYAIAVDSDLRFVHHQGLARILEHCGPESFNDPSILPLFESCRFTMIANALVQRRGTFLEQEQWKTVPWSRCPENKSNTQKLLDIISSLPGLFEKTDRVLNERSQWVAGDRTIVREETPTTVPSLRQQLDSMLLDLIAWRYHWSADNSQAQDILDWALHRVSDESYRPGINEVHGPDVYGLNVGNVPFETLDTELEANADTFSLMQEAVFYITAVITIERLGKNLAGAARAADAIDFYNTPNFSTCRCYFENPGPSRLCQIFPEPKDRVSKAASWNLNSAMISEAPVKSSSSDSSASFAMPIDLSPSHSISSSITGTTLLPGDGRFAGQLRILNSLIKHLPQSRPYVLSTLAAMGLSHCVHDTRPMDGNEAIAEAIRETMLKSRFGDAADVLLKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPN5</accession>
    <name>A0A2T4BPN5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1452085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPN5"/>
    <dbReference type="STRING" id="983965.A0A2T4BPN5"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="200" mass="22326" checksum="04BEEBF9F3AA5440" modified="2018-07-18" version="1">MHIADRRHSASHVRYRQLGGYPSHCSHGSHQWREHHIKHGRARALSVSGQTAWWVFAANTSRLSTTGALLHQQLHERQHPQPLLRECYEWLPPSHWGSSNVAYTDTTPYAVSNSSNLAQSTDGWYIGRSTFISVNRATVKYNDDCIAFKPGSTFAIITNITYTGSHGISARNLRSCAGNTDTATVSSGTFENFVLKDTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPX2</accession>
    <name>A0A2T4BPX2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1406552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPX2"/>
    <dbReference type="STRING" id="983965.A0A2T4BPX2"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="284" mass="32516" checksum="57F8CCD6F7B4783D" modified="2018-07-18" version="1">MASDEQQPQVTLHWLNRSRSQSILWLLEELKVKFDIKLYHRNEQFLAPPELEQVHPLGKSPVVVITPPPSTTTTTTTSDGEQQQQQQQQPIVLAESGHMVQYLCEHFPEGRRLVPQKWKPGMEGKFGGETEAWLRNQYFLHYSEGSLMPNLVLSLVIGKLKQPPVPFFIRPITSAVANRIFASYIFPNIHRHIRFLDQQLRTSGGRYLCCDHLTPADIILSFPLFEARGSLDSMGEWRGGSWKAEFPRVREYIDLLESEEGYKKSTETIRKLEGSATEATPAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ48</accession>
    <name>A0A2T4BQ48_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCAAT-binding protein subunit HAP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1386790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ48"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ48"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="269" mass="29824" checksum="1C9B7DF54FED07E3" modified="2018-07-18" version="1">MDSQNQSAPTHPSHNRPAPVYDPSQGGHYGYMQLASQGFAPAELYTGPWANVHQGLTGQYKDILTTYWQQTISHLESDTHDYKIHQLPLARIKKVMKADPEVKMISAEAPILFAKGCDIFITELTMRAWIHAEENKRRTLQRSDIASALAKSDMFDFLIDIVPREEATAHAKRTTTQPSAAQSVPGAGQAPMPGQHAGMAPAAGHPSSHPMATADYMGGHALPSEQDYRQAPNMYPGQMDNMYQYSAMQPQQHCPANRRQPPMPSEDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ49</accession>
    <name>A0A2T4BQ49_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_9015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ49"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ49"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="747"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="976" mass="107635" checksum="119CFD947A0324A6" modified="2018-07-18" version="1">MEHSLGPACRLRPAPDADADADKEDGVPAVTAQFFYTAIYPIDDPLSGSASASGADSKPSKAPLRPFSHDDNDMLQQAWLGLSSESHRVQHADIRSGREPAPDAVKSDLEKRGLLVRKLASKHKRLHSEKKQTRKSTTEVAEAAIPETLLTACCPDLATDALTELDTAFCSLVRKTNRLFDVEEVVKDVTAVMNQSLQLQGAPSPRRQVPVRHPLLARERRAGLPSDGASIQRKAAGFVAADDHGITGKPFVRVPSTEQAPRTASSEQQQQQQQQHNDEPLSESSSQLNDVVIEADREIPVEQPIPVETTAPDLEDEDRDVVVGLARLHKVCLHTLQMKPVYWSPINDVAVVTRGTWFYKDTMMPVSAAVANQLETGYQELRPWTETWCDELRCAIDVGASGEEKVSHRLWPKEGEGLYRNTPVPTEPAISAHPFCASHCFQGEAATEGYMEPPKVDGEAHENHHQRAYSSYSVIYKDRANAFLLKPSLQPSSYYNRRPIMKIMKGVTVGVPVVRGFDRLSWERLHRRKKTQPTKSTAHGSAPDACPACEAEKDRSKVTDLVLVAHGIGQKIAERVESYHFTHAVNGFRRLVDSEFQSPAVQEILHNSQSRLMVLPLNWRIGLSFEDGGALQTGMGANNSSAAQPFSLKDIEPNTIPAIRSMISDVMFDIPFYMSHHKGKMIAALVGEANRVYRLWCRNNPGFAENGRVHLVAHSLGSVMAVEVLSRQPTIAPPLDLARPEPETKFFEFDTRNLFLMGSPTGFFLLLERGALTPRRGRAKPGVDVSETMADNVGGEQGMFGCLAVDNIYNILAREDPIAYFLNGAVDPVYAASLKTAYVPTASTSFFKSFGDVMRTVAKGMGAANPGSSTTDDGRPPTVRLPSQLELEVHDFTREEIAEKKAFLLNDNGQIDWFLRSGGGPLEIQYLNMLSAHSSYWSNTDFIRMLCFEIGRRPGRANTLPAMRAVKATRRIPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQB8</accession>
    <name>A0A2T4BQB8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1344010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQB8"/>
    <dbReference type="SMR" id="A0A2T4BQB8"/>
    <dbReference type="STRING" id="983965.A0A2T4BQB8"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015568196" evidence="5">
        <location>
            <begin position="19"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="119"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="289"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="447" mass="50321" checksum="A080BF1C9FBCD5A5" modified="2018-07-18" version="1">MKLSAAQLLLAGASLSAAMPHLDSPRQRLLNGMDLPSKYGDDSKPYTPGHRDANDNYVDAIGKKLDPKPWRNGMGASVLGPYNRDRSRQSPDMIRPPSTDHGNIANMRWSFTDSHVRIEEGGWTRQTTVRELPTSVELAGVNMRLDKGVIRELHWHKEAEWAYVLDGEVRVTALDYEGGNFIDDLKKGDLWYFPSGVPHSLQGLGDNGTEFLLIFDDGNFSEESTFILSDWLAHTPKSVIAENFHLAPELFDHLPKGEKYIFQGSVPGAIDDEAPKGKHVKKSNYQFTHKMLDQEPKKTTGGQVRITDSKNFPISKTVAAAHAVIEPGAIREMHWHPNADEWSFFISGRARVTIFAAEGTARTFDYVAGDVGIVPRNMGHFVQNIGDEPVEMLEIFRADEFRDFSLFQWMGETPQRLVLDHLFADDKEAGEKFWEQVKDAKKDEITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQI9</accession>
    <name>A0A2T4BQI9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1442493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQI9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQI9"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="165"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB71555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="491" mass="53306" checksum="6BEA9D15C1716D5E" modified="2018-07-18" version="1">MPSLIPPIVSASASSASNSASLDHLYHHQPPPRLPLGALPQSPIQSQAPPPHLHPQSHHFQLHPGHGHHQQPHHERDHRLPPPVASYSTHSHHLQHDPLPQRLDSSQSGHPGAAEHRDHSQHALDDSSRSHDPYPSMTAGALVHSESRQPSSASLLLPISNVEEATGRRYHLDVVQQPRRARMCGFGDKDRRPITPPPCVRLIIIDVATGKEIDCNDIDHSMFVLNVDLWNEDGTREVNLVRSSTSSSPSVSSTVTYPYGSISVAESSHTYGQSAPPPSREAPYSVSQNANYAPEYQTQPTYTQASSAYPSSGTYGPPQQYFPQHQAYRAETGPPAAMQSTVGGFRGYVQDQNALTKMAVVGGQPQGMFTRNLIGSLAASAFRLTDTSEHLGIWFVLQDLSVRTEGPFRLRFSFVNVGPVAGQNGAKVNTGRAPILASCFSEVFNVYSAKKFPGVCESTPLSKTFAAQGIKIPIRKDANLKGGDGEDDYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQJ8</accession>
    <name>A0A2T4BQJ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1143886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQJ8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="14423" checksum="2F901B62C2D8BE47" modified="2018-07-18" version="1">MLYILFCIFAGYVFSSTVGYTWHLVTMSVYTSAYVVRGRTFGLFGNSSKRLSIHALPVISRIISCILTNSRHMDNINNISVTLRSGPYPLQSAAFCPSRDIPYNANLNSRTDCSPIGYSQSHVFHSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR56</accession>
    <name>A0A2T4BR56_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1343555</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR56"/>
    <dbReference type="STRING" id="983965.A0A2T4BR56"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015538683" description="Beta-mannosidase A" evidence="16">
        <location>
            <begin position="18"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="20">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="17">
        <location>
            <begin position="260"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="19">
        <location>
            <begin position="732"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="18">
        <location>
            <begin position="838"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB71756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="922" mass="104265" checksum="E512991D4E446124" modified="2018-07-18" version="1">MGWVLAALSLVASCATAQSIFNLSDVSWTVSNGVNATVPGKLPSYAHIDLLAAGVIVDPIYGFNEWNQFWVQRMNWTYTSGPIKGLKSGNGLTSWLVFEGLDTFCEIKLCGQKVGDTKNQFRKYTFDVSDILPKCKDNPVLSLNFGSASKIVLDISQRSDLCMLSSVPVGQEFQGRVYMRKQESDFGWDWGPQFAPAGPWRPAYIVQKARTDPVFITNTAIDIYRQGQMPNLSPDQSKPWVFNASMDYIGTLPKGSQFHVKIVDSKGHTLKEANLVDITQSDGTITGSTVINTKVDLWWPSGYGEQPLYTATLSLISAGVAKHATVTKRVGFRTIVLNLNPITEADKAKGVAPGASWKFEINGHEMYAKGSNFVPPDVFWPRVNQTKIKQTFELAVNSHFNMMRIWASGAYLPDWAYDLADEMGLLLWSEFQFSVAYFPATPDYLAEYEAEAYYNTRRLNHHPSLALWAGGNELEYLIYGWWLNPRNNTQLEDYETIFQQHLAKCVYANTHSISYIPSSTYHGYTSLDFNSVSPQTSRYDYMESPDAIYLDTDFYNYDGSIAFQYSGYPVGRFADEFGFPSMPSVYSWRDAIPESEFNFDSSYVRHHNRHLSGGSDFFSSSANGINQFTDSIKLWYPLPQLSDPVANFTAWTWTSQVFQADYYQAQIAFYRRGSGLPNRQMGSLYWQFNDIWVGPTWSSTEHNLRQKVAYYAAKDIFSPVIVWPFYDEATDVLEVWVISDLWEDVSGTATLQWVDWNGNALDVDLPVQVEPTHDRSFTINFDVQPINATRLVTYPALSTFFACKNPSSNALLSISIKAGGYTHSKFFHPQSLRLSSIADPGLVMTKSLNGKTAQFQIIATKGVAAWVWVDYPSVVRGYFDQNGFWLNKGENRTITFTVWEDWSKGAWIDDVVLRSIYDNMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR65</accession>
    <name>A0A2T4BR65_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal fungal transcription regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1473358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR65"/>
    <dbReference type="STRING" id="983965.A0A2T4BR65"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="417" mass="47994" checksum="7D69A9FD7E26D624" modified="2018-07-18" version="1">MTETTLPLVGGREEASQQTQTQPPRKKHAKLFHKKSRTGCRRCRSRRVKCDEARPICSNCTRLDLECGYGPPSTTPTSEGDAVRIPAALSVENNLVESHGVLHLPETEARRKLELELFHHYMTETAPTLGTERSAQEFIGPALCRAALRSDAVLYGLCMLSALHKAYTSNFSEPQHMQHHSTYLNLALQSHHKHVARLDTDNVDDSCMVSSTLRVYAYVQLQRRDLRPYAPPIEWLRMSNTSTVVFRKALALIEKNPDSLSGKLTLEISHHLDEKRRLEHSDELLHLLRHQEPHELEEEWNDEVYHVYRRTLSCFGWVWKHRFDRHPPPGMSRRIHLFPMIVDSQFVDYVAQRRPRALVILAHYFTLLALHRDFWYVGAAGFREVRAIAAELPLAWQGMLSQPLEILQDPSLLCKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRE3</accession>
    <name>A0A2T4BRE3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LUC7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1364867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRE3"/>
    <dbReference type="STRING" id="983965.A0A2T4BRE3"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="268" mass="30053" checksum="A6043897372AC2C9" modified="2018-07-18" version="1">MAAEQRKLLEQLMGASSSSRAAQLSLNDPKVCRSYIVGTCPHDLFTNTKQDIGPCPKVHAEGLKAEYEALSEREKHKYGFEYDYMRDLQKYIDECNRRIDAAQRRLEKTPDEIRQTNALLKTISDLTASINNGLLEVEILGSMGEVSRAMDELFRVRQAGQQKAEREKELKALSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYAQMRKTYDAFPKEMKGRSRPPMDDDGPGGGPRGPRGPGGYRSGRGRGHRGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRY0</accession>
    <name>A0A2T4BRY0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1342701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRY0"/>
    <dbReference type="STRING" id="983965.A0A2T4BRY0"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="2"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="438" mass="47735" checksum="EC0F1087A0410D9B" modified="2018-07-18" version="1">MSWAMACFFGFVAAFSVANLYYTHPILHILAQDFGISDERASLVPTLLQAGYATGLLFIVPIGDIVRRRPMIISLVFVTSLIWLGCTLANKFEVFLGLSYVIGLFTVTPQLMFPLTVRYAPARHRPTMTAIVMSGLVFGILVARLLSGIVAQYSHWRNIYWMSFGLQISIVISALLFMPDFPVLRPGATYPGILLKMVQLPFQQPVLTQSALIAFLLMGMFTSFWTTLTFQLAGPPFHLSTLVIGLFALVGMSPVLFSPIFSRLVMTRLHPSATLIIGHLILLTAVCIGTFTGTFSLAGPVIWASIGDFGMNIVTVSNRMAFANIEPTAQNAVNSVYMVSTFCGQLFGTSVGNTLYAGGGWIRSGSLSIGLVGGGLLLVLVRGPHEKGWIGWSGGWEVRLKKLREREAEETQAASDVTAHPSDEEVGIRLESEATEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRY9</accession>
    <name>A0A2T4BRY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inorganic phosphate transport PHO88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1465805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRY9"/>
    <dbReference type="STRING" id="983965.A0A2T4BRY9"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="193" mass="21401" checksum="E11EE6002BDE97C5" modified="2018-07-18" version="1">MAISPQITNLMIILGMMQVTKRIPFEDENVLNIVRAIYIASNVLIAGLYFYIQIQINKKKDMTTLKYVEPAPMGSSEEGKLVTTTIHAYDLNQLRQAWRGQLMGIAMMSFMHLYMKYTNPLVIQSIIPVKSVLESNLAKIHIYGQPASGDLKRPFKQAQGFMSAMQGASGSVQSDKKAVEAAEKAGRGGAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS69</accession>
    <name>A0A2T4BS69_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1395121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS69"/>
    <dbReference type="STRING" id="983965.A0A2T4BS69"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="215" mass="24719" checksum="BC30BA143EE10E84" modified="2018-07-18" version="1">MALNVFRVAGDFSHLASILILLHKMVQLKSCSGISFKSQGLYLLVYLTRYLDLFSTDSLYNLVFKILFIGSQGYIIYLMTNAYKPTNAATLDTFRVQYLLAGAAVLAILFPVKYTPSEILWAFSIWLESVAILPQLFMLQRTGEAETITTHYLFALGSYRALYIPNWIYRYLADPKYKVDWIAIIAGIIQTILYSDFFYIYYTKVLKGKKFKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSG3</accession>
    <name>A0A2T4BSG3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1394937</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSG3"/>
    <dbReference type="STRING" id="983965.A0A2T4BSG3"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="K Homology" evidence="15">
        <location>
            <begin position="172"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="341"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="423"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB72257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="536" mass="57256" checksum="5F35A517D1EA957C" modified="2018-07-18" version="1">MSWRSQGITGSNNIPLGRRRFGSENGEDGVAAGVEERELKRGRDPEPRTEADGPRRRKKRNRWGDASENKAAGLMGLPTAILSSMTSEQLEAYTLHLRIEEISQKLRIDDVVPADGDRSPSPPPQYDNHGRRINTREYRYRKRLEDERHKLVEKAMKTIPNYHPPQDYRRPTKTQEKVYVPVNDYPEINFIGLLIGPRGNTLKKMENDSGAKIAIRGKGSVKEGKGRSDAAHSSNQEEDLHCLIMADTEEKVNKAKQLIHNVIETAASIPEGQNELKRNQLRELAALNGTLRDDENQACQNCVSFAESVAMPATWLEIVPTARGVPTGVTTQAADPQQLMQELGGGGAAPAQIEAGPSSNNYNGNSDAKPWQRGPTGGPAPWRSRNQDSNEGGSGGGSAAPWARDRNRGHDNGNGNGHGGGENSYYGHNNYGSSSSGGPAPWHQPAPQAAPQHQAPGMGAYPNYAAYGAYGAAPGMGAPPGLPQAGAGLPAPPGLGPLNALIQQYAGAVPPPPPPSGDAPPPPPSDQPPPPPPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSM1</accession>
    <name>A0A2T4BSM1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clathrin adaptor, mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1405713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BSM1"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="142"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="437" mass="49418" checksum="F0EB6AC342E98A1C" modified="2018-07-18" version="1">MLSGVLIFNQKGENLIFRAFRNDCRPRLADVFRIQVISNAQVRSPILTLGSTTFSHVKHENIYLVAITKSNANAALVFEFLYRLIQLGKGYFGKFDEEAVKNNFVLVYELLDEIIDFGYPQNTETDTLKMYITTEGVKSESRPEDTSKITMQATGALSWRKADVKYRKNEAFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLSLPSGNKMGTKATKAAAGSVTLEDCQFHQCVKLGKFDSDRIISFVPPDGEFELMRYRATENVNLPFKVHAIVNEVSRTKVEYSIGVKANFGSKLFATNVVIKIPTPLNTAKITERCTQGKAKYEPSENVIVWKIGRFTGQSEYVLTAEALLTSMTNQRAWSRPPLSMNFSLLMFTSSGLLVRYLKVFEKSNYSSVKWVRYMTRAGSYEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSR0</accession>
    <name>A0A2T4BSR0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1342082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSR0"/>
    <dbReference type="STRING" id="983965.A0A2T4BSR0"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="331" mass="36726" checksum="2BB02B9BF5BCBFC0" modified="2018-07-18" version="1">MSENLVFITGASGYIGSHLVGDVLKAGHRVRVAVRSEEKSLLIKELYPSASDRIEYVVVPDMSQPSAYQDALKGVKYVFHLAGAMVGRGTNLQRDFLDPVVKGTLAILESSAKEDGIRKVVIVSSFLSLMPMDGIRRNPFHIEANTGERYAGDIGMAFPEGLPGRLLKYQTGKVVAHQAYRDWVKETNPKFEVVSVHPSQVFGPSLVHRSADELRGVNYLMWTTLHSDEPLKTPFLMVDVRDVSRALARISDANVPSGTELPLTGPAYTWKQFADTVKSNNPSLDIAFEPEQEPTLTMDMDATDKYLKMEWTSMEDTIKAFVDQQIAFSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT56</accession>
    <name>A0A2T4BT56_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1341866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT56"/>
    <dbReference type="STRING" id="983965.A0A2T4BT56"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000219">
        <property type="entry name" value="Importin subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="940" mass="104640" checksum="C1723D588DB23C29" modified="2018-07-18" version="1">MAWQPNPESLNQLAACLKDSLSGFDKSAQKQAELMLQQAKASPDINNYLAYILSSSEPPEGLQVNEKDYHLVRSAAGVMLKNNVKSDWKSIPEASLQLIKLAVPMGLQDKNSQIRNLAGNIATEVIRRGGLMGWPDLLPQLLEMIGNSSGQFSNEAQEGAMSAMTKICEDNFKMLTKEVNGQRPLNHVLPQLIAATKSPLWRVRLGALTAINVFTPRASQAMMNSIDDLLQHLFVLSADENAEVRRQVCRAFVHLVETRPDKLQPHIGGLVDYLITQQKSDDEELACEAAEFWLAIGEHEDLWNALRPYLNKIIPVLLHCMVYSGEDIALLGGLSDDEDEEDREEDIRPAFAKKSAARTANGEGNLSADANPNGGASRMDEGLEEGELDDLDDGDDDENPDERWTVRKCSAAALDVFARDFGGPVFEAIFPYLSQNLKHDEWPYREAAVLALGAVADGCMDAVTPHLPELVPYLISLLEDQEPVVRQITCWALGRYSSWAANLSDQAQREQFFLPMMDGILRKMLDKNKKVQEAGASAFANLEEKAGKKLEPYCGPIIQQFVKCFAKYKDRNMYILYDCVQTLAERLGPFIARPELVNQLMPALTERYNTVSDQSRELFPLLECLSYVALALGQAFTPYAPPIFLRCVNIIHANLEQGIMATTDHALDQPDKDFLITSLDLLSAIIQALEDDKSAELVKSSPHPFFELLGFCMEDPTDEVRQSAYALLGDCAKYVFPELQPYVPTILPILLKQLDIDSILDEEIESGFGVINNACWSAGEISMQHLKGMQPWVPELLQRLVEIMSNPGVPKGLVENAAIALGRLGLGNAEQLAPALPKFAGEFLAAMQEVDPTEEKATAFKGFTMVVGQNPQALEKVLLDFFVSIARYQDMNLRNPIKQELHEVFQNVLNVYKQLIPQFDDFVNRLQPQDQQALKTIYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT64</accession>
    <name>A0A2T4BT64_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT64"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="64" mass="6817" checksum="6EA0437C0E795055" modified="2018-07-18" version="1">MAGYPSPPPDGLIDDGSRHTPELLSLLSISSSASFLTFLLYSVCSLSLLVHEIERSCSGSHRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTC0</accession>
    <name>A0A2T4BTC0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1341748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTC0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTC0"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="572" mass="64181" checksum="7D7144B5479D2D4E" modified="2018-07-18" version="1">MAGPGGGPPRRSHTKSRKGCDTCKRRHIRCDESFPQCRNCTKHKIRCPYNDVQVPDAGRSATPDKPDLMWTPQIEAAIGEWQRTGMFPFPSLGIYPAPSPHQYSLEDLRLIYHVASLHYQLMTQEANNLTLWTRYIPTLLKIGAEYPFVMHALLAFSAMHIAFLTDCPLVGSMAFEHRGRAFNGLHEALNSFSRSTSDAILAASLVLSWQATSWRDWTKLMQGTATVIEAMDAWKHESEFTDFIAESSTFPTAPPSPDPERRAYHPQKDDLEAYQRTLDQVMKVEAHLKHFKEEACLMQMQHLTGFLKGVRKISPTLPIAQQFERLQLLRTWLFWVPVGFIQTYQCSPASLVAIAHLYTAALLMERLFPEIGAAYFGSLSMAPIEEIARRLMTLNVASSVKGSYQTPLTLMEYPLDTVSEFRSRMGWMSPQRTPSFPTFHPPNFPVMREEGPMVPSSEPYTPYGNPAFSYSAESMPMLNSPTPAGPHDGLSPLAISSPYLSQPYLNVPSPSYGISYSPASSTFEASLAYSDPEEYSGYDMRGFQSSHSPIFEDAQSSGYPVGFVLPQQSVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTS7</accession>
    <name>A0A2T4BTS7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1341517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTS7"/>
    <dbReference type="STRING" id="983965.A0A2T4BTS7"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8350" checksum="B9C5DD46B86D5A10" modified="2018-07-18" version="1">MSAPLFWSTPLKYCSWAARERPAFFWSVVVGAAGPLLMPIVPPIRHMLGDVDPAPIPVTYPVPAGPRKQLTGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU34</accession>
    <name>A0A2T4BU34_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1425386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU34"/>
    <dbReference type="STRING" id="983965.A0A2T4BU34"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57477" checksum="BDE2BA8C64C4C7C4" modified="2018-07-18" version="1">MSSASTASSSCQPYVSRLDSLADAATTSQPRSSSILGQTAPRPLDSDRLPEPTPSEAEVYLIKFRQWLEFFPFIHLPPDVTAEALHREHPFLWLCIMSVTSMSMPQQAAMRDRVRQDIAQRMIVNHDRTLEMAQGLILLIAWATMSAGPGSKPFLTLYTHMCSCIIYELNLTKFPNEEQFATVCFKAWGGRNVPPSKERTMEERRLVLGFWYITSVCSSFLAKMESMSWTQHMQESLEVLENEREVPSDETLVAIVKAQLVGDEARKLLICDFVGRDYGRPDPDKAPTYVHKKSLLLQLQKIRDTLPPAAASKAVIQMQLFITETQIQSVGLFGGARIPDAPRIDAMYAGLVAARAWYDVLFSIPLSEFIGMPFSLYVQLAQIHALLYRVTTLDDPAWDKEIVRSTADLGNYLDRTIDLFTKAEALYPLRGGPEDVSIFGKCTKVLRNVRSNWEPAIVQQPMGGLPTPNSQVVPGAAPQPTLLVDHSMMPDQDLSADFGDINWMTQVFGPWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUL9</accession>
    <name>A0A2T4BUL9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1425007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUL9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUL9"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="211" mass="23164" checksum="BF9DE993BE7675C9" modified="2018-07-18" version="1">MPYNTNAIPPRKEPTGQTQLPLSRVKKIISQDPDVQMCSNNAAFVITLAAEMFIQHLTEEAHTQAKLERKPRRNIQYKDVANAISHRDHLEFLEDVAPKTIPFKKAKAINQARLRGEPVPTNGTSASSKSKSTKGQQHAAGVNGQAKASGTNPFTLSLRNEEKDSSRKHGEGNNGVGNGNRTDDPSDQLELETRRAARPEEDDDADVDMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUW1</accession>
    <name>A0A2T4BUW1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIRA-interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1404840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUW1"/>
    <dbReference type="STRING" id="983965.A0A2T4BUW1"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="299" mass="32888" checksum="5ED480E8DB4FF672" modified="2018-07-18" version="1">MASLNMQRTASRLVASAVSRPLPACQVRAAASRLSRRHLTTGIRIPVIAASRPQPRKTQHSVPSGVRTIFIQTESTPNPDALKFLPNHRIIPPDMSTPFIEYLNPRSTISPPHPSPLAAKLMNIDGVTSVFYGTDFITVTKAGDANWAHIRPEIFALITEAITSGEKIVNVVERKADEAGQAAAEEDSLAYNENDSEVVGMIKELLETRIRPAIQEDGGDIEFRGFEDGQVLLKLRGACRTCDSSTVTLKNGIEGMLMHYIEEVKGVKQILDEEEEISLQEFAKFEEKLKQQRGAAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV58</accession>
    <name>A0A2T4BV58_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1425147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV58"/>
    <dbReference type="STRING" id="983965.A0A2T4BV58"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="3">
        <location>
            <begin position="699"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="942"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1046" mass="113618" checksum="5559F0059EB66465" modified="2018-07-18" version="1">MASTPFRSGAGDPLIARSSSIPRDEPQEVPESFMAASGDFFSADDLQQYIGTLGPEHFKNFWDAPPIVPTGPFEDSTSGSLFDEDFDSGAASPKAPVTAADTVSLNANGHLDLMAAFRTAEDSVSPFTLAGQSSTFLGAPDGGEMFAFGSSDEAVTNQPFVFSSSLGDSSAIALAFQNNYRQSDMDVVARPEELVQQVITPPDMAGPRGQKRVAAPEPPASAMQTAETSPAATPSFQSPQWGQIGQPQQNQTPQHTEGIPQMPTLDFPAFTYLGEYGVNIQQSALKSRVETQMMVTITMSHLPFGVTKLHLPPHTISKPKHRLRPPPVPSPDTLELYVSLVCTTPMEQPELRRRALQRAAEVDHRYLPTPEEVEHETQNGCQIRICPKCMERERKRANRKKEHERSDQEELWYLDESHRIIIFNTFEMSDWRPPTAQKEKGSDKPPQAELFRQCPTAMQVVVPMRLACYCRHQKEKTGFRVIFTFKDWKNNVVAQAMSGSIMITDDHKTTTPSAVDDAPELEPQGPAKRRKPSSASSLGSSSAPNAMSEPPSSAESQALTTHHQAPSTSLPFQGGSAQLTTPSVSPVFSPAAHAFPQLQGPMGAMPPQVPAPSGPHALNALAHEIPSWFTPPTSRRPESREDSVMLYSTPVSPNSGGSLSPSRGTLPNGGNIVSHSQSPQANHFAMGPAAAATPVSRPPPIIHKVIPPEGELSGGTEVTVLGASFFQGLEVWFGDNKATTTTFWSEASLVCLVPPSTVGGPVPLTLRLLPGAQPPRGMQAPLQSHMGRQQTTYTYKFNGENENSTRSPYSFLNVNLASLPIFNAYIPQPAPLMRKVQEMMSASPSGKGTDDSSDDGSKADTRWWDLSSYMNSAAAPPAYNEIYPAKDAQVEDLDAKSVLSVARAAAEVEADVKKRRVRADEQESSNAQALVTYEEHQRAKAAKAASAGESSSSSSSSSSSSAVIQPPAILEIGRKHAITKEQQENFLRAREQKLKKLSNDRNLFFIWIPLLLVMICALLYSYCPSLFPFIFASIRALIHVLLRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWF8</accession>
    <name>A0A2T4BWF8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiotic recombination protein DMC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_136350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWF8"/>
    <dbReference type="STRING" id="983965.A0A2T4BWF8"/>
    <dbReference type="OrthoDB" id="5420410at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29221" checksum="D833832AB9EA1A33" modified="2018-07-18" version="1">MADSSREPGGFIPPQGGLPSPAPSSASSRAASSLPHPRRTPLRPGGSKEDMVRRYAEEKLMTISRRYVKKFGGAQEGDDVVGFRTFGEVCKELDEVVNILWQSGTPILQVQFLLKLASDFTQYVRSFPPSPKASFDLLRKLDHCFASLLCGQDIETKETLPGFENGLRMGMTTTDMVRCRSLVEQTRLLMVEIMSSGEPEDEDEDEEEEDDDEDDEDDGGGAGWGVDDDDDETYLDAARVYEHTIVQLEKRLGDSLGGSIGGWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWR2</accession>
    <name>A0A2T4BWR2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1294876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWR2"/>
    <dbReference type="STRING" id="983965.A0A2T4BWR2"/>
    <dbReference type="OrthoDB" id="4890185at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="12659" checksum="D479EAFDF69779C3" modified="2018-07-18" version="1" fragment="single">EPEQEASRRPDTTRDQRRDCQLMRRLGYTQSAISRELGLSLGQVQYALSHAETPITRPGRPSKLSEAQVEELKAFMAASPANERMPFAKIPQALGWDVGEYCIRHALRKLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX18</accession>
    <name>A0A2T4BX18_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_21403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX18"/>
    <dbReference type="STRING" id="983965.A0A2T4BX18"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="603" mass="65837" checksum="F7A5FC6CD38132BA" modified="2018-07-18" version="1">MDPGFASGKAMEASAASSSPASADAASSPASAQSSSSPATASVSPDADARIIYGRVDAANEDNIDLLSSVAEHNALGRAKLLRPSAAQRRDDAIMQERDTDAAGSSTAEQTAAAPLKASGKPPPLLATPAELIDTILSHLSPCDLAAVSATCRTLRQHALSDLLWQPLVQQNVPAVQVTSPGPCASFRELYAAHDRVWFLPKYKIWFCDRDLTGKLVLVRYDPRRGCIEGYQLVAVSNQSTFQHWSADHDVIIHSFSPVVKLHLDKPVLQFRVQDRQEDGGLSKRPGANRFADEIPMRLDDRVGGMYNNFMLTKPLSSEEADRRAHLGYPYGNMWPSPVIPANHYVSGDIERRGVAALSSRDRPQTRSEVSDQTFCIRQWMQLTGTPGPLRFMGERGLAGALRALVRDLVDEEAAGIGIGGLGLHIGEELITYSTLDPALYTPTPEKPWRGIWVGDYSGHGCEFLLIHQPDDPPATDAELGVFRDENDTDEAWEKKRLDARVYRGRLEGIKLTGDPNVPRGEYTFVVNDMGPDGLVGTATDAQFAGARMVKSEGHIAATGFLRDKFIESQLILISHDKLAQHWVGFGHISFLQRVNIDQFLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXC8</accession>
    <name>A0A2T4BXC8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1424480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXC8"/>
    <dbReference type="STRING" id="983965.A0A2T4BXC8"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="604" mass="63789" checksum="DC8660E27ED88AED" modified="2018-07-18" version="1">MDEGTGPTTITPETAPRWSLSRRLRSLRRAFTTREGLLGDYDYGVLFRPNLPFMGKGSRSGRSPFFGLNDHMPVFLGLLLGLQHALAMLAGIITPPLILAGPGGANLSTEQQQYLVSTALIVSGILSSIQITRFHIYKTPYYLGTGLISVVGISFSIIPVAQGALSQMYANGFCPSDADGNPLSCPRGYGALLGTCAVCALLEIMLSFIPPRILLRMFPPIVTGPTVMLIGVNLIKSGFQDWMGGSGCTSQALCPSPTAPHALPWGSAEFLGLGFSVFVTIILCERFGSPIMKSTSVITGLLVGCIIAAACGYFDRSGIDSAPVASFIWVHTFPLSVYGPLVLPVLAVFIVCLTESIGDITATCDVSLLEVEGMIYESRIQGGVLADGLNGCLAALMTMTPMSTFAQNNGVIALTRCANRKAGYACCFFLLIMGVFAKFAAALVAIPASVLGGMTTFLFCSVAVSGIAIISRGVPFTRRNRFILTAGLALGYGATLVPNYFSTVFTYDGGNKSLRGFLDAIVLVMETGFAVTAAACMILNLVIEEEMEDDISADGDDDDDEVGVIVRSAGTFSAKKYEQNNESDEMGGVVGEGSSSSARGEKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXV4</accession>
    <name>A0A2T4BXV4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF829-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1338223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXV4"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22122" checksum="3A0C068CBD410E68" modified="2018-07-18" version="1">MAATKTPAAKREPPPLSYMEHLSPSVSYYNPASLNDTNPNSDKNNKQDITAPGTKGHPELILVLSWMGARDVHIAKYIAQHRALFPSSPILLVRSPASHLRLTRPAQNLNAEALRRQSLLPRETRRTYLYGTADAVISWQHVEDHARRAESSGFKVRKERFEGGEHVSLVRKDSQRYWQAVKETWEGDGAVFGAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY34</accession>
    <name>A0A2T4BY34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1423976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY34"/>
    <dbReference type="STRING" id="983965.A0A2T4BY34"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="149" mass="16682" checksum="203BE08EF3F4C5B4" modified="2018-07-18" version="1">MALPDDKELESILGDGVDLNTFKQILEMDEPGDNEFSTSIVFGFFEQAEETFESMDTALNEKDLDKLSELGHFLKGSSATLGLIKVRDGCEKIQRYGKQENLDGSPEPDTNVCLERVKEALTAVKSDYEEVEVGLKKFYDKDDEEEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY82</accession>
    <name>A0A2T4BY82_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1424022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY82"/>
    <dbReference type="STRING" id="983965.A0A2T4BY82"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015506996" evidence="1">
        <location>
            <begin position="18"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="440" mass="48831" checksum="3BA50FDA2B7135BA" modified="2018-07-18" version="1">MLDMLVLLFTFATPSRQSPLPKQAQMGLADAVTRPLSFTTNGTFQLSIFEDLHFGENAWDTWGPQQDINSVKVINKVLDREAPGLVVLNGDLITGENTFLENSTLYVDQIVQPLVQRGLTWASTYGNHDHNFNISGEGILARERRWPNARTRSMVPGRDAGVSNYYLPVYAAGCNELQCSPELLLWFFDSRGGFYFQERHPDGSQVGQPDWVDVGVVDWFRQTNAMLVARHGRTIPSLAFVHIPTEASQALQTEHGQASVDRHRQPGINDDYPVAQQAQGWCPDGRNDGTCGYGGQDVPFMQAVATTPGLMAVFSGHDHGATWCYRWDRLVPGMTVAGTGVNLCFGQHSGYGGYGNWIRGSRQVRVDLRSLRGDRWEAKTWIRLESGDVVGAVVLNGTYGRDWYPATPNTMTYCPTCNYTVVTPGPGSLQRKVAGVRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ49</accession>
    <name>A0A2T4BZ49_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1403093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ49"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ49"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="600" mass="67205" checksum="AD99E0F803462AD2" modified="2018-07-18" version="1">MATSPSPAPSSEANTKPLRRAAVKPRKTFRELFLHRLPHYNGPYNVGYMDIEVPVREPRPVSNLRRHGKPVLRLDTILMGIYYPCDLQASPGAHRVDWMPRPRVATAKGYAKYLHIPALPVTAYLACTSLFTKLPAFRNAKLAAHWPEDMCKDSGPTGQKAREEEGDPASRPKFPVIIFSHGLGGSRLCYSSICGELASFGFVVVAIEHRDGSGARTYVSLPGNVEAAAIELSTAEIHTNNDGDEKGGKDKKVQRRRQEGLNPYYVVDYILPKDNAQDTRPHNSRGVDHTLRSAQIVLRQEEIKEAYYILDLINSGHGADVAAMNLRKKGNLGSSSIGLNGINWDAWKDSMFLSNVTMMGHSFGGATTVQTCRDDSLEWLGQGVILDAWGQATPPAGETRKERVTKPIISISSEAFMHWKENFDKVVEFSNEARESGALCWMLTIVGSIHLAMTDLAILYPQWMSIFMKSMVNPTRAISLTVTASLEFLKIILPPEQTKYNMWADEQFLKSAEPPSDPTEVLRTDHAPDPKWVAVRLKIPNEFSVRLKAWIRRTWRFIICAGREVVELSHGLYDFGEQEEVWTHICPTREAVEAHMNQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZL3</accession>
    <name>A0A2T4BZL3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1034403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZL3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="102" mass="11495" checksum="8A86566FF764198E" modified="2018-07-18" version="1">MPSGLDLVASRFRQPIIGIRLLSVHVSMKHTPSDNEAAALCQANSLRAWQRSIPAQRRDNIQDAVTPQPDKGYPILLPPIGSRKHNSTRHHEERKPWQSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZP9</accession>
    <name>A0A2T4BZP9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1432141</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZP9"/>
    <dbReference type="STRING" id="983965.A0A2T4BZP9"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001100">
        <property type="entry name" value="PRK00133.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="435"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="571"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB74778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="655" mass="73812" checksum="EDE892521A7DBBEF" modified="2018-07-18" version="1">MAVENPILPVKGKKNVLITSALPYVNNVPHLGNVVGSVLSADVYSRFSKLRDRPTLYICGTDEYGTATETKALETGQTPQELCDEFHVKHKEIYDWFEIGFDYFGRTSTQKQTEIVQDIFLKLHERDYLEERTTKQPYCEKHDSFLADRFVEGTCPKCNYDDARGDQCDKCGSLLDPFELVNPRCKVDGATPVPRDTTHVFIRLEKLQPEIEKWFQDAHKKYGWPQNGVSITQSWLTKGLEPRSITRDLKWGVPVPLPGYEKKVIYVWFDACIGYPSITANYTDQWEQWWKNPDEVTLYQFMGKDNVPFHTVIFPGSEIGTGYNWTLLNHLSTTEYLNYENGKFSKSRGIGVFGNQAKEIGLSPSVWRYYLLSNRPETSDTQFEWQAFQLANNSELLANFGNFVNRIIKFVNAKLDGVVPEFNPSYKDETFDFSAWVETVNGLLKEYVDLMEKVHIRAGVKAIMEISREGNNLLQGRLDNANLAENPERTHTTIGLALNLCHLLASVASPYMPSTSESICKQLNSELAFIPDVWEPTAIKAGHKIGKAAYLFTRIDDKKIEEWKNKFGGSAETRAAEEAAKRKKQEDKEKKKAKKAAKAAEAAKNAGAAKDTKAEGAPVDAKAQDEASAAGGMAASSAEVTKDLPIREKKSVDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZX1</accession>
    <name>A0A2T4BZX1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1336572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BZX1"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="47"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="262" mass="29857" checksum="E606D657C82C3425" modified="2018-07-18" version="1">MSGFVSADYSSNPVDIPDTFLTTPPSEPVTIRPVPWKDSPVPEYAKCKAWILDNVLSPEECSQLIAYAEASARREKPDDSPWRPALISVAPGVETKAPGYRNSDRIIWDNQLLVDRLWDRCAQAEGLQELVATAPCTRPDYNRNRKGTWKFERLNERMRFLKYTPGMFFRAHCDASFRPDTTDGSILETYYTVHLYLNDKGLVGGATAFLSRDRSKRLNVNPKAGSVLIFQHPMLTHEGAEVLEGTKYTMRTEIMYRWEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C082</accession>
    <name>A0A2T4C082_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1432211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C082"/>
    <dbReference type="STRING" id="983965.A0A2T4C082"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015724613" evidence="7">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="413" mass="46625" checksum="121F0F53BB52B52A" modified="2018-07-18" version="1">MILRAAIFVLLALVSLAFCAEDFYKVLGVDKAASDKQLKQAYRQLSKKYHPDKNPGDETAHEKFVLVSEAYEVLSDSELRKVYDRYGHEGVKSHRQGGGGGGGGDPFDLFSRFFGGHGHFGRSSREPRGSNIEVRVEISLRDFYNGATTEFQWEKQHICEKCEGTGSADGKVETCNVCGGHGVRIVKQQLVPGMFQQMQMRCDHCGGSGKTIKNKCPVCHGSRVERKPATISLTVERGIARDAKVVFENEADQSPDWVPGDLIVNLGEKAPSYEDNPDRVDGAFFRRKGHDLYWTEVLSLREAWMGGWSRNLTHLDNHVVRLGRKRGQVVQSGLVETIPGEGMPIWHEEGESVYHTHEFGNLYVTYEVILPDQMDKKMESEFWDLWEKWRYKIGVDLQKDLGRPEPGHGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0W6</accession>
    <name>A0A2T4C0W6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1463727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0W6"/>
    <dbReference type="STRING" id="983965.A0A2T4C0W6"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="459" mass="51201" checksum="6B32B2559F6F2F72" modified="2018-07-18" version="1">MAEKQSSRFTVIIAGGSLVGLTTAVALQKAGIDYVLLEKREIAPHLGASVSIHPHTQRVMEQLGIWPEIKAAVVPLETRRHYDENGFLFEDSCILKEISKMTLGRWTTFMERRFMLSCIYNQVEDKSRTRAQTGVASYTETEDGVEVVTDKGETIRGDVLIGADGIHSTIRSLMADHIASTDPEAAKEMRSGFVSNYHCIFATSKNANATADGKPFLPDGAVHNVYYSGFSGVIAAGVPGLVFWFLFVKSDRTTYTPNTPRFTEEDMEATIAKYGDHAVGPGYTFKDLWASKVRANMLPLEEGVLKPKWNTGRVVLMGDAVHKATINPGLGGNLAVEGVVHLMNELVPLVRRCEAAGRRPNRSEVAAVLDTYEKKQRPHANTIVTMSGYVTRYEAMETWWLRVLRRVSPWVSDKTKAGGFVGYINEGPWLNYLPNPDDERKWDEKLPISNDERKWSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0X0</accession>
    <name>A0A2T4C0X0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1439768</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0X0"/>
    <dbReference type="STRING" id="983965.A0A2T4C0X0"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015591756" evidence="14">
        <location>
            <begin position="21"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="125"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="156"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="516" mass="54011" checksum="011715A99568D6D1" modified="2018-07-18" version="1">MRPNSVLLAPLALYASGALAFYPYTPPWLKELEEHNSGEAKRSADSGLTFDIKRRASRRAPASQEEKAAWQAALLSHKYSESTLPNPSPDTGLSKRDNQFSILQAVDPNAPNTAGLAQDGTDYSYFVQASLGSKKTKLYMLLDTGAGSSWVMGTDCESQACSLHDSFGPQDSDTLKTSNKEFSIAYGSGAVSGSLVNDTIEVAGMSLTYQFGLARNTSSDFVHFAFDGILGMSMNSGANENFLSALEGAGLLDKSIFSVALARASDGHNDGEVTFGATNPSRYTGDITYTPIPSGTDWSIPLDDMSYNGKKGNVGGINAYIDTGTSYMFGPSKNVKALHAVIDGAKSSDGVTWTVPCDTTTPLVVTFSGVDFAISPKDWISPKDSSGKCTSNVYGYEVVSGSWLFGDTFLKNVYAVFDKAQMRIGFAKRSSSDVGSQSFVTATNTGTTVASATAASTGTATFGASSSAQPTMGLDGQETSGAAQPTQTTGSSGAISLQSSGAALALGILSFLVLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1E5</accession>
    <name>A0A2T4C1E5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1431841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1E5"/>
    <dbReference type="STRING" id="983965.A0A2T4C1E5"/>
    <dbReference type="OrthoDB" id="5149446at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="205" mass="22562" checksum="90CFD2325FBFB163" modified="2018-07-18" version="1">MQRNVCNCSLNSLQNISSNLSQETLSFDTILQISSDFIGYFKTIIACERCVSTKRVTNMLSQITSRLVCFYEAAYLNAATNAIQPRARSVSDAGLLLSPPLSQHGQQSPLSPATLLPGPRCQSMFGEMKLGRLTLEGHEARILAEVILVDTCLELNEKIQEWRLVMDETAEATEEQCDAASSNCLDRLAKLIGLLQFDGLPVQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Z6</accession>
    <name>A0A2T4C1Z6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1321093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Z6"/>
    <dbReference type="OrthoDB" id="2146436at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF1">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="198" mass="20113" checksum="8616788CB12CF522" modified="2018-07-18" version="1" fragment="single">AILSLASLSQAHFLMNYPKSIGFSDDDEGTSPCGSFTPDLSSGSSQLVDFHVGGDSLAMRSTHPQTNWLFRVTLDGSAKSDWQQIFPIVQQSGLGNFCEPQITLPSSFEGKKGVIGIVADGPDGLLYQCIAANFVSGSIDPPSACKNASVTASFVNDSKLSALVSGSASGGSSSNSTGSSSTSTGPSSTQSSAAAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C202</accession>
    <name>A0A2T4C202_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1431294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C202"/>
    <dbReference type="STRING" id="983965.A0A2T4C202"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="8">
        <location>
            <begin position="44"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="478" mass="53352" checksum="2A6F5D7B9F4976FF" modified="2018-07-18" version="1">MASPAPSTRRSLGSSSSGLPRPPGDNPTISINTLVSHLLRSKRSLSSITLVLRAEEIIRAARNQHEETVVLMAQTKFLRAAITDQAQLLSRLAASLQATNEWGKKDFFQLLKHMDDVDAQLRGTMDMLRETPVDPALRPPGEESKNLMDFVDEASVGAIQESMRACISELQAIQVSFDGDLLRLETDIRNTRKIMDSAPIPAPPNQGMSDMMLDLFEHSTVMAESLASLTRHFDMCVTAVRTTEGAAALARRMAAEATQTQGSESVSISGVIAEQESNKSDLEPQTAQDRAEMLRVVIQDADMVEDVVRDIQEHLAQIELKYTVLQDMAERTRAANAGILDAFTQLSEVGHRLASYQAAEDDFLSRWAMEKEVIFAKIEEMTEMRVFYEGYASAYHGLLIEVARRQTVEDKVQATLRKAQETVDKMLEADRAERETFRQEVGEFLPTDLWADMQGSVRRWKIVQDDDDQSLDANRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C241</accession>
    <name>A0A2T4C241_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M440DRAFT_1439351</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 19"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C241"/>
    <dbReference type="STRING" id="983965.A0A2T4C241"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="146"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="473"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="512"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PTB75651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="566" mass="63973" checksum="885AF104F0B9262F" modified="2018-07-18" version="1">MDTDGVAASPAAPHQPPYQYTPNQGYEQTEEIPRELQRQQAGTRNAAADAEAAEDDDDDDYLEDIFDDADEQDEEDWAAGDGDLTKTYNRQRQLNDGGAVAVPRSNQQKPKANTLASVDDQVSALARHAAKIRLDSGKHDGERDKDKADRATSEQVLDQRTRMILLQLINRGVVSEVHGAISTGKEANVYGAVSYDEETGAATQRAIKVYKTAILVFKDRERYITGEHRFKGGFDKGNNRKMVKLWAEKEYRNLRRIYSAGIPCPEPLALKLHVLVMGFLGDKKGWAYPRLRDANLQGDDVDQQWQALYVQLLGTMRRMYQVCKLVHADLSEYNILYHAGKLYIIDVSQSVEPDHPRSLEFLRMDIKNVGDFFRRKGVDTLPDRTIFNFITVPEGPVEEPALGEALARLYETRRDATNEEEAAAEEVDTEVFRNQYIPQTLEQVYDVEKDVKRLNLGEGNDLVYSKLLADQVVAPKGDGEKDDESDEDDSEDESGEGASLDGEGEEGDDEGQFDKGRPRGRKFEDKDEKKQHKLAVKEAKREKRKEKMPKHMKKKLVSSTSRKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C280</accession>
    <name>A0A2T4C280_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1257932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C280"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="89" mass="9959" checksum="27ABCCBD8A775A1A" modified="2018-07-18" version="1">MAAILPVCFGASHSFLACCFSCIFRFPLTFHSYKPPASRWNRQPTRGLRLVRSCKAPLSLLMLTGSPGTCAFTLFLTPYLSTYMTCDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2H3</accession>
    <name>A0A2T4C2H3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1305548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2H3"/>
    <dbReference type="OrthoDB" id="4900333at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="281" mass="32376" checksum="48C91802DF83C8A1" modified="2018-07-18" version="1" fragment="single">AQELAAQKRRMERRLRRVITMRQQKPTLVSPATARGAQDLLDRWDEIWTTYKPEYLKTLEENVRIFLYNDPKYGAALARIHDLEVDLFRLKYASYLYLAEAPKEAQDAALQLVTARDTAATTEVDNNTPPHPDPTPGLYEEQLPFFTTQDWSAILNRMRQERAAHRAENRKPRHLKYVYVLDEDRYDSWSFPTDESTLINLCSTLARLHVTTVEALVDKMDEYVKLKGRGLHYSRAATAEQLFQLMDVLEADIRKLDSAPEGCEEHVPAVREAITDAAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2U7</accession>
    <name>A0A2T4C2U7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1463489</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2U7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2U7"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01489">
        <property type="entry name" value="Uba2_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="58"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="14">
        <location>
            <begin position="355"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="15">
        <location>
            <begin position="487"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="584"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="73185" checksum="62E0D108F310E9FC" modified="2018-07-18" version="1">MDAPRDAAADAHPAAVSQEPQQPQRVVASHPPPPTPQRSALAARDRYNHQSLGASLNSLVKHARVLMVGAGGIGCELLKNLVLTGFGEIHIVDLDTIDLSNLNRQFLFRHEHIKKSKSLVAKEAAQRFNPNVKIVAHHANIKDLEFSVPWFRDFKIVFNALDNLDARRHVNKMCLAADVPLIESGTTGFNGQVQVIKKGLTACYDCTPKDTPKSFPICTIRSTPSQPIHCIVWGKSYLLNEIFGVSEDDFDHSADADNAHEIEELKKESEALKQIREAIGTPKFPKLLFDKVFNADIERLRSAPDVWKSRRAPEALKYDEVMARASQLLDSKNAILADGQKIWSLEENFVVFIDSLDRLSKRLLQMRATKDASAPEPTITFDKDDDDTLDFVASSANIRSTVFGIDLKSRFDVKQMAGNIIPAIATTNAIVAGLCVLQSFKVLKGEYGQAKEVFLTPFANARLLAPDRNREPNRDCPVCGVYYTSVIADLTRATLGDIVEGLVKNHFGYGDKEFAVSCRVGDEIRSIYDPDETGNLGKKLTELGIKGGTFLTINDWDDELVDVEIDIQDGILDNQKESFRTVHAGRPEIPHKPQKASPVESDGDSHGQPNGKHSLDEDVVEEPKGAKRPPPDDESPPLKRAKVDSSDDDVVVVEDAGGAIVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C316</accession>
    <name>A0A2T4C316_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1334688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C316"/>
    <dbReference type="STRING" id="983965.A0A2T4C316"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56640" checksum="985A1817247757F6" modified="2018-07-18" version="1">MEFDKLSITDRKIIVGIDFGTTYSGVAWAETQRPDRRTAITTWPISKTTREGESSDKVPTKLRYAKDEVQWGFSIPITAPQEEVIEWFKLDLDPSLKNIGQAVANDGARGGRDADKLVADYLGALCEHLLYTLREKLGESVVKSTPLEFVVTVPAIWSDLAKDKTKRACQKAVQSLPLAPGSSRTLIHLSKLGKEDGFDEEVLAEAMEVFEKKVKRQFTLAAQPDETYTIPVGGLANNKALGITRGRYALKASDLKTIFEPVVLEVIKLVKDQITVSNVPIRAVLLVGGFGASNYLKERLRNAVDKSIQIMQPPNAWQAVVQGAVMKGLANSAPDTLTMVKVQNRKARKHYGTEWRTKYDERIHGHMSEKKSWSGMEGYYKVNAMEWFIRKGDAVSENEPYITSFVWTGLVAHGRIRKMRMTIYCDQTSEEAPIDRNSNVQVLAHVEADVSHIPEHLLNRRQGKDGSMYYELSCKIEAVYLSASTTYTLLYNNQRYDTVTCEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3P3</accession>
    <name>A0A2T4C3P3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1333348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3P3"/>
    <dbReference type="OrthoDB" id="5424391at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="404" mass="44750" checksum="526E2B52662D3706" modified="2018-07-18" version="1">MFTTKSAQSLRNLFASYHEPPSISKQQSQKLLDGLKASFRSHLDREYGRSSSDSAAPAPAKAGDAIEPQSNTARRRSAATLHLKSILANPLFSYDSNKQNAAASHLPKALWVPDRDPMDVFDHAVSRGMMTLKAATGCLVAKGQQLGEGNALFATSDTALRVVRWLRSSGAESSLQFLDKPAFVQALAPFLVAEKMEGIAWEWITRTMNESANISEEQRIARASSLLSQLVRIKSQSHYGNLDAAIQAILEAEQLFQHSPLLPKLLVQPWRSVSWLSTVEAYSRAMPTEKLFEAHMATAQRLPRPFPVETAHLHLHHPTHPDHAPAMRFFNDKKRLRKLVQALGPEKVNLAKFTGMGTIPWIAFLGHDTVNHLQQSGRSEEARGITNILRSELSDIFAETLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Q7</accession>
    <name>A0A2T4C3Q7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 69 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1401622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Q7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3Q7"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="39794" checksum="EB5E551244D66785" modified="2018-07-18" version="1">MHWNNAQVLKDYWNDAVVELTETFGADNVFVSVYESGSWDDSKEALRELDAELARRNVPRRVEVSETTHKDEINKAVEERGEGWIDTARGRRELRRIPYLAKLRNRTIKDLIELSEKGITFDKVLFLNDVVFTIDDVLTLLDTNGGNYAAACSLDFSKPPLYYDTFALRDSEGNAHAMQTWPYFGARDSRNALVNHVDAVPVTSCWNGIVVMPAAPFVSSTKLRFRAVPDSLAAHHLEGSECCLIHADNPLSKSKGVYLNPRVRVGYNYPAYAATHPPGRSWVSAWDIFTGLWENRIRRWTTWTFDRWVVRSRVRRWEKEQSGNREPGEFCLINEMQVLVENGWAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Z4</accession>
    <name>A0A2T4C4Z4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1231061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Z4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="109" mass="12348" checksum="0405FA94013D7A00" modified="2018-07-18" version="1">MSESYGQIGGQLIPQSSPFFCCSSCSSQFSRLLLPPSQSICVFAPLQDTTIEIPVLPHCTSHFTSTWPLPTSRHFYLYLIHAKYGWNELADASYVFSFARRCLHQEHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C550</accession>
    <name>A0A2T4C550_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1462568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C550"/>
    <dbReference type="STRING" id="983965.A0A2T4C550"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="173"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="270" mass="28890" checksum="9E068A12FA11A8CA" modified="2018-07-18" version="1">MAGFIAPCRSGRALSAAAAAASPSPLSTFLPAASSSAGRLLLSSHSSSSSAAGRRRQAFSTTHAPRSKLGRTPLSVPPGVEVVMGEPRAIRSATSYKPVVRKTITVTGPLGTLTLDVPEFVDLAQSAEDKTATLSVRDPNEKEQKEMWGTSWSYLSNHITGVSEGHTAILRLVGVGYRASVEQRGAKETFPGQKFLCLKLGFTHPVEVGIPRGVTVTTPSLTRILLEGPDREALMSFAGVVRKWRPPEPYKGKGVFINDETIKLKQKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C594</accession>
    <name>A0A2T4C594_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1401101</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C594"/>
    <dbReference type="STRING" id="983965.A0A2T4C594"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="80"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="304" mass="34581" checksum="F791710DEBAEF9E9" modified="2018-07-18" version="1">MSVIMEQSAAQSSSYAHDKVDSNDIESGYASGQSDYSPSPRTEKPVISLSKSHIEYLNEQMESMHPMDILRFCKIMFPNLYQSTAFGLTGLATMDMLSKIQKENPESRTVDLIFLDTLYHFKETYELVDRVRERYPEVPIHIYKPDGMETAQQLEETYGEKFYETAGDMYDWIVKVEPLQRAYDELKVAAVLNGRRRSQGAARGSIPIIELDEERGIVKINPMAAWSFAQVKQYIDENNVPYNALLDKGYKSVGDWHSTSPVGEGEDERAGRWKGQGKTECGIHNKKSKYSEFIAKKEQTAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5T9</accession>
    <name>A0A2T4C5T9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1456564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5T9"/>
    <dbReference type="STRING" id="983965.A0A2T4C5T9"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="368" mass="40642" checksum="038ECF47AAEC01AE" modified="2018-07-18" version="1">MHSATHDVSSRKLLITGVTGFIGFKTLLVALERGYAVRAVVRNDEHISQLAAKSQLISEAYERENLDFAVIPDFLACDKWHQFLDGIRSIIHLASPLAREVGAHFAHRLASEDYEQDIVKPAISMVYTVLEAAAKVPSVRRIVITSSCVTLIPFEWNFQPDSERLYSVSDINANPKKPYGSAMEAYWASKAYARLATPAFIAANKPHFDYVHLLPSVVFGPDERIPPNGAAEELLKDSRAAVIAPALDGSTNSPFPFVGVPVHVADVARAHVDAVDSTRIPGNTEYILSSDTPEGTVWDRDTAAVARKYFPEEVESGLLPLQGTLPCIKFRLDGASTERVFGWKFVSFEQTMRELLGQYLSLKRNTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6F8</accession>
    <name>A0A2T4C6F8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1400065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6F8"/>
    <dbReference type="STRING" id="983965.A0A2T4C6F8"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="61"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="260" mass="28669" checksum="1BB1958F464606E5" modified="2018-07-18" version="1">MPSIQGFNTLRARSYVLRLPLFTRAILLGIAAFWLASLPGYWDVRLWGSLIPDKISFATGYRLNTFPLVHLNLFHAVLNAVALAPLMERFESEYGTLTTLALFFGPLTTIPAVLYLFIEIAILRANHAVMGASMWVFLLLGMEAIRTYKSNPYLVIGTYHLPTWTTPLLMIVVVAALVPNTSLLGHLCGVAVGYVAGLGYVKLLAPPEWALRWIESRLNLLAILPHYVSVDQKTYGRFGVLPTTNRPVASTPVELVGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6T4</accession>
    <name>A0A2T4C6T4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRTase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1329893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="203" mass="22831" checksum="F9EAAD0841C45D49" modified="2018-07-18" version="1">MVEKLYVTYNDVHKLCQQAATKILDEFKPQLIIAIGGGGYVPARILRSFLKQPGSPNIPIQAIGLSLYESLGGDPQVEEIGTKVTRTQWLDLSALGEMENLVGKRVLIVDEVDDTRTTLEYAVKELEKDVELARQRLGPDAPKAEFSIFVLHNKDKPKKGQLPEDMVKNRYLAAVTCGDEWINYPWEAIDIDEHDRLAAEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6W4</accession>
    <name>A0A2T4C6W4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1390647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6W4"/>
    <dbReference type="STRING" id="983965.A0A2T4C6W4"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="15409" checksum="A09DC6FF44B019AD" modified="2018-07-18" version="1">MASPVGRAKSPSTSPRGKEQSASASASPRHSPSQSAGVATPLAGLVAGDADNPVPVQVDTDAYPDNPADADSTYGSDQDSAYTGSVTSSIYNYQYENGRRYHAYREGQYADVLMEGVKREFRSRDLRLITSYRFIIGRKPLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7F1</accession>
    <name>A0A2T4C7F1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1213437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7F1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="94" mass="10030" checksum="D599875B0A10992B" modified="2018-07-18" version="1">MQPLGALHIPANPCSYLVSKRPLLALAAVIARARTVKWSVSLLLCSGHQPPKSQLDRLPSSIWASPLAPPPPGLKPARPPNYSGLCNSPFSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7I7</accession>
    <name>A0A2T4C7I7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1215209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7I7"/>
    <dbReference type="STRING" id="983965.A0A2T4C7I7"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="281" mass="31984" checksum="C686E6065B784A49" modified="2018-07-18" version="1">MDILELQRWAFMPNLPADIAPIRDLLTRYGGIPADEIEPHLMRIREAAWASSRMPFIGRWKFLTLNDTDDSRYQQALFRLRLSQSRDALLDLGCGLGQVLRQFRADGVDGSRLFGLDSSPHFISSGYDLFQDRDVLGAHFAVGDVTNPDDPSLKELDGRVSIIHAGSFFHLFNWRQQLCIGKRLVRFLQPGIRNAFIYGRHVGVASNQEVDMSDSSPCLHTHESFQRLWDEVGELTMTKWKVEIEPSGEKMAWLPGNPKSAHAVNFTIYQVPRNEIKKSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7K2</accession>
    <name>A0A2T4C7K2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1462193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7K2"/>
    <dbReference type="STRING" id="983965.A0A2T4C7K2"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="479" mass="52039" checksum="8E11AC2DCF79A0BA" modified="2018-07-18" version="1">MMMLCPTHPVSLISLFFNPRFLHPDSFSASTMHLPLIIAFGAKLALGHFSNSSDPWPQFHDDDDAAAATQPWVVGDFRFFGCAASSAGFPLFKKVAFTDFMNLDFCAAGCPGRYFGTSDTDCYCGDELDAETADKVDSDQCDTPCPGDGSQICGGHAASAWPAHEKQQSESVILSLYIRLGEDHHEHDQKQEDTCEDDEEEEHYHGGWHFTRPPTHQTYTSTITSTTTSTITSCSPDVQHCPVGNKVTQAVTVTTELCPAPEWSKKKITCYGDLCAPEEPCHDDDEQCQRQRVVCHGDSCHPEPCSDKDNDWHKLVVCDGNDSSSECHYRQCAGEECATKIVCYDGRCAKQKCWGDECRANLVCKGPECRHEACGQGEEDCHEHRVCDESGDCHARPPCSDPECPVPPPPSAAKPEVPPPAAAPTQQHGPAGHQTGYPQPAAPTNGYSLPRPTGVPVVAGSAKLGATLFGVLLSFVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8D1</accession>
    <name>A0A2T4C8D1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1421517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8D1"/>
    <dbReference type="STRING" id="983965.A0A2T4C8D1"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18439">
        <property type="entry name" value="BRCT_BRC1_like_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="337"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="770"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="845" mass="94424" checksum="828DDD0CAF4A4C24" modified="2018-07-18" version="1">MADDVEGIFSDCAIAFVPSDKLAPNLCHSLGTILIEHGAEIIEPRRDGTIPVERVTHIISNTIDFPQYIETQAIMIPVVTTQWITASISRRKQAQVRPFSPDPGMIFSEVIVTCADLPQMDKESILGAVMALGGQESKDASKLCTHICALSMDHPKVVAALERKWKGKIVLPHWFDDCFKLGKRIDEGPYLLPDPDILKKGADEDLDIPTNKNLIGASSATPEFLPLTSDNSSRPPVTVFQDRSILLCEDLKLTARLRNALKDIIEYGGGRLVDDVDECDTLICRYRDGDEYVRASQACKDVGNLSWLYFLIVHNEWTSPLRRLLHYPVPKGGIPGFQDKRITVSNYGGEARIYLENLIKACGAEFTRTMKTDNTHLITARNSSEKCKAAPEWGITVVNHLWIEESYAKCEMQPVNVKKYNHFPSRTNLGEIIGQTSFNESRLRDLYYPGGEHTMSPSAKRKRKILEAAEKNAYSHGPAEGVVVPEVGQKNLDVMKLDKEETPASRKNRRDAQLVTPARSRPARADKENETPMIMSSGGRSAKSKAMDKLSSIAPDIALYEKEKKRTTKPGTPFGGKKAAELMEKEKEKGSAKKQAAHKDGDDEERPAKRSRPSLPGIEMRIILTGFPRWVGNQTKEDQDRRKLRDLGIQIVSEGHPCDYLAAPHVVRTVKFLCALARGPTVISSTFIDQILDTGKIPDVSKFTLKDTEAEAKFNIDLEQSVARAKSHRGKLLRNVGIYCTDKVRNGPDSYRTIAEANGATFKIYRARSGSTIKPTTAEQDNFLPPDPVYLLSGNSAEEKQLWTRFREMAERGHMEPRIVSPDWLLDVAMAQQVRFDKKFLIDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8L2</accession>
    <name>A0A2T4C8L2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LNS2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1438331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8L2"/>
    <dbReference type="STRING" id="983965.A0A2T4C8L2"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="420"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="630"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="749" mass="82771" checksum="13DAF70167774855" modified="2018-07-18" version="1">MQYVRNLSDSVSTAWNSINPATLSGAIDVIVVEREDGTLACSPFHVRFGKFSLLRPYEKKVEFRINGVKQPYSMKLGEGGEAFFVFETSDSIPESMQTSPLVSPASSPPFGPADASSAMAEPESLELDGDAGKPRRPSPAIIQPQPDENGIITPLSSSPTLSSSQPASGSWRKAFDRRPHSDDVLRKPVRHHDEAISDNESPSESEKSHSPPPLGPQEAIARARALSKGLSAVNIPTHITETGDLMLDMTGFKSSEEDMLRAEVLARNILSEEMEGNYDIGALFGFDEEGNLWVYSSEDAKQAAMNKTIESSLQAHRRAVAADAISDPGYQSDGSDLASAPHAPSHRRTESDAGPGGMHTPPRTPTGSLEPPKSYAKTLRLTSDQLKDMNLKYGENAMSFTVNRATCAANLYLWKHHTPVVISDIDGTITKSDALGHVLNMIGRDWTHSGIAKLYSDIAANGYNIMYLTSRSVGQADTTRAYLNNIVQDGFRMPHGPTILSPDRTMAALRREVYLRKPHVFKMATLRDIRNLYGPNGGPFYAGFGNRLTDQISYRTVDVPRTRIFTINSNSEVSLDLLSLNKLKMTYVNINEVVDHYFPPVDTLVRGGGEEYTDFMYWRDDPLKIDDFSASESEEDDHDDQGSAYTDDEEEEEEEEEEVGEGMGDSYISHEEYDDDEDEEEEILDSIENDDADDEENYEDEVEDEDAEASGDETRVVEDITAEIITGVGDLSVEEKARKQEDDDQKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8P2</accession>
    <name>A0A2T4C8P2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="9">1.2.1.16</ecNumber>
            <ecNumber evidence="3">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1375616</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="9"/>
    <dbReference type="EC" id="1.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8P2"/>
    <dbReference type="STRING" id="983965.A0A2T4C8P2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="14">
        <location>
            <begin position="51"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome recycling factor" evidence="15">
        <location>
            <begin position="611"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="554"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="724"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB77939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="802" mass="87297" checksum="619D989AE0F3FCF5" modified="2018-07-18" version="1">MALLHKIASPSALRFAPGISSLLVRKASTMAPKLRDPSLLKQNVCYVNGEWVSAKSGKTFKVHDPATGEVVGTAPEFTPADTESAITAAADAFKSFRTLTGRERAKLLRKWYDLTVENAEDIAQLITWENGKPLADAKGEASYAANFFEWFSEEAPRVYGDVIPATVPGNRVWTLKEPVGVCGLITPWNFPAAMITRKIGPALAAGCTVVCKAPGETPFTALALAELAHRAGIPKGVVNIVTTMDNTIAIGEQLTTHPTIKKVSFTGSTTVGKLLMKQASGTLKKLSLELGGNSPFIVFDDADIDAAVTGAIMSKFRSSGQTCVCANRIYVQEGVYEAFVNKFVEKVKAFKVGNGFAEGVTHGPLIHDRAVSKVDAHVQDAVKKGAKLLVGGQKLPDVGSNFFQLTVLRDMTADMQLASEETFGPVAGLFPFKTEAEVVQLANNSEVGLAGYFYSRDLERVHRVAEALEVGMIGVNTGIISDPAAPFGGVKESGFGREGSKYGIAEYQITKMITRHLFSLSSPTTAPLTALAHKPRIPPSARPFNTSATLLKKRKIAPASNSPSPTPSSSPKADKSSSKDNNSNSSQPNPEDPLDFSSLLAAYATIDAHFKAQLQAVLHGGRFNPDVLGALPVAVKSHDEQHHQKHDHHHDHQHAAPAGAAKTTFPLRELAQIVPRSGRIISLLVNEREYIKPIMSAVQASKDFNQQPQRSEDNELELLLRVEMERKEDLVRRVKEACQGWRERVRQARTKHEKALKEWKKNGVVLPDVVRKADKELQKVQDKKMKQIDAEEAQVIKQLDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9B7</accession>
    <name>A0A2T4C9B7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1389900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9B7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9B7"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="363" mass="41054" checksum="3969CF253E90BB46" modified="2018-07-18" version="1">MDDDEQVTRPDYRAGSGEGERPPPDEYTRLLPNRVNSNREFLAPDDPAVSPYNLFSIRVLRYLTFLFSALTFLWWLVLLISVFATPPGFHQKGSGFLAFGYTSLTFANLFFALLFFSVPSKAVRVPAIVISAILALDLILLLAVQKTRYEEGWVGVVSVAWALLMSVWSIITDRTVQWGKAEEEERLTGRAETRKSLAEWLEVLLSTIAYSVMVVAVVLITLNIILRALDARIAPPGKLYWVDDNKYRIHLYCHGNKTDDNGKTVTTVLFEGGEWPVEYSLWDFADNAVKNGSISRYCFADRPGLACSGDKIKHDDKWASKQKDLTGLTDKLLGWDIVDGAPHEVWRTLEGREKIEERLKKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9L5</accession>
    <name>A0A2T4C9L5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1351502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9L5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9L5"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="185"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="611" mass="69053" checksum="5CD1BD9F8D7D15D8" modified="2018-07-18" version="1">MNILSRSTFATARIGDRTSSWTCSICRGHLARAAIKPPARQFIARRFASGRTWSQGRERANDGAKSGPANARLILFASTGAAAGTAVLAFTDEIKNSYEAAERTGRVVVALAVCINDYRTTLNAKSSVEEPEKQAELLKACHKRCAERTLRVLEKNGGIFIKLGQHLSAMNYLLPPEWTTTFIPLQDKCPVSSFESIQEMFRRDTNEDLWDYFSEFSEEPIGAASLAQVHLATIKDTGRKVAVKVQHPELEAWAPLDLALTRYTFSTLKRFFPEYDLEWLSSEMDYSLPKELDFREEAENARRMKAHFAKIPALPLVIPEVMWAKKRILVMACESGRRPDDLEYLDKNGIDRDEVSATLARIFNEMIFGDGAPLHCDPHGGNLAIRKNDTRRGLGRGPNFDIILYDHGLYRDIPLPLRRSYAKMWLAVIDGDMDRMKKYAHEVAGISEDDFPLFASAITGRDFSIVSKEGSILKTRTPDEEKNMSGALQEGLIVDLVQMLGRVPRIILLILKTNDLTRSLDENLHTSQGPIRTFMILARYCTRTVFHEQLEEILQKGSVLWPPNAVRVFAAWIGFVRVELKLEAFELWLRFKRVLGLRSVEFGGGPLRQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9S2</accession>
    <name>A0A2T4C9S2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1399480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9S2"/>
    <dbReference type="STRING" id="983965.A0A2T4C9S2"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000035">
        <property type="entry name" value="TrmH family RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="307"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="642" mass="72078" checksum="A2B89D32691A01C3" modified="2018-07-18" version="1">MVALGQLRANGFSRQLFHNLNRPGAYPLQITRPATLSAIHRGVRRSERVQYGDQDRGRDSQGRGRNDGLTRRALDGASSPRQQQKLRKKLGRKAAEDEEEESTKETRRKRFLNPDSSYGKRSLVYQLRHGAFKEQAASLVQEPVRPLPYQRLESRPRRSTEASQFAEERSERPRHSSGRSFGRESSRRNDSRGSQFTEGRSERSRYSGDRSFGRTSSRRDEFQASEFAQQRPERSRDFGRRSIDRSYDQKDTQGEMDRPRESFGRSGERPVGRRDDGYDDVETPEPRERRNQMMAMNITYTTAASQFLYGKSVVKAALEQGRRKLYKLFIYGGENRKDSKDNAIITRLAERRGVPITIIPNEDQRLMDKMSMGRPHNGFVLETSPLPRLPVKSLGRLEETLGKLGFHVELDHQSREEEAINGQDTFIPRKNSNAPKPFVLLLNEILDPGNLGGILRTASYLGVDAVGITNRSSSTLTPVVLKAAAGAVEEVTIFSVDSPVSFIEDSRKHGWKTYAAVAPPDPKLAQRHGDKFISTATVEAEQPLSKHPSILVLGNEGHGLSKPIKVAADYELSVPYFVSNSCVDSLNVSVAAGLLCHAFVRAPPIVKPTAPKLEEASPEETSTEDRLATERQESQDGKEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9T3</accession>
    <name>A0A2T4C9T3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1399460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9T3"/>
    <dbReference type="OrthoDB" id="4966402at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="67" mass="7768" checksum="7DF51269A479FE18" modified="2018-07-18" version="1">MCDWEEFLFTCNHSQVRLKSYCHFARNDPNHGCLGVKVLRSSWRQSVPCDDCLLKGYPVGLSHRGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9U2</accession>
    <name>A0A2T4C9U2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1190056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9U2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="137" mass="14175" checksum="2C10751EA3824D9F" modified="2018-07-18" version="1">MAPAPAPAPAPAPVAASCCPVGAPSAASPAHLPGHDTVRYEPSPGWISSLLGQAWPGMDDRMTPGKEAAENPGWTPFPRTAAMVPKNGVLKGWDAGETRPPANPRLCTLHCGCRWAPGTEAAVRSAGRQLEGLKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9V1</accession>
    <name>A0A2T4C9V1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1390025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9V1"/>
    <dbReference type="STRING" id="983965.A0A2T4C9V1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000613">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="293" mass="31684" checksum="644DCD8ECB17DCCC" modified="2018-07-18" version="1">MDPYSAEGELINIHTHFYQSQYQQVIDFDTSSFSPENAIPARVLKLRARLALGQAEDVFADVQGETVPDLEAVGALAEYNLGRTDSAIKTIEKLAESAGDNVTVQVVGGTVLQAAGKSEEALALLSKHQGSLDAVALIVQIHLQQNRTDLALKEVTAARRWAQDSLLVNLAEAWVGARVGGEKYQQAFYVYEELAQGSSTFSVQSLIAQAVCEIHLGRLEEAQSALEQALQKDPTNAEGIANLVVLNSIAGKNSTEELLESLKKVNPHHQLVLDLDEKSSLFDKAAAKYSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9X1</accession>
    <name>A0A2T4C9X1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1327857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9X1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF5">
        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015430862" evidence="3">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="322" mass="35524" checksum="EB3519A4EFB98F40" modified="2018-07-18" version="1">MMRIAVAGGRGLGFLLATELAQAANAYNVVVLSRSARPEFEPFDVQVHVVDYHDHGSLGYALQGVDLVISTISGAEQLNLIDASGRGRVRMFVPSEFEGSLSRRPSRNDPLDRGSSQALALLKQWSESSRMKYTVFSCGLFMERFHPYGLGSTFNIGHGSGVGGAGEFLVNFSMATAEYTERDSKGHSVRVCLTSVYDVVRFVVAAVDLGPSHWPQEFTMCGERMTVRDLVNACSTASNKMSSAVFTRHVHQHAELEAYLSYSAQLCDYDKVAYYQRLLATANGRYDFSQATLNEIVNRSNSVHVQPVTFSAWLASIWTQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA33</accession>
    <name>A0A2T4CA33_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps54-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1420517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA33"/>
    <dbReference type="STRING" id="983965.A0A2T4CA33"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="811"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1105" mass="120984" checksum="D4B9BFC35F8A702C" modified="2018-07-18" version="1">MYSSPIAGRSVDNLAPLSPPGRADYPFHSSRIAQGHGRPHSRRSSTASSIHSIGGTLDTSLSSGSAVYESGQNAISTLLQPPIVRTGLQPHTSAPASSSHKPPTARDIPPVTLTNIPQIDPEEFAPYLSQIGALYDQLRRVKESEEEENALRKGNRPEEQVEVASEGLLRPAARGRLPRKGSTASLSSITSVDTVSSLRRPPGVSRKSAQGPPPLSTIPPVYFDEDFHLENPRTFDVVSERSEVIQKHKDEGNGNVVAPRKTLATNAILQEKLSWYMDTIEIHLINSISTASTTFFTALGSLKELHSEAADSVQRIKALRKELEALDERVAANGLMMVQKQRRQENLRQLSDAVWQLRLITEGVATCESLVDAGEVEKALAGIDSLELLIAGEREESSEQGEMPRLRDLRSASALQGVNLDLTQLRFRIGKAYESQFSSMLLSDVRQHVESVSSADVLLRWSNAAPKARGNPLRSPSVFPTYLAGTDTLKAQLMPVMSGLHGAKHIAIAATAYREDILREIRNLIRRPLPSSNDDDNMSMMSISTASGGRHLSSQEKSANLARNLRALDAEDAEALLTKIYISVTETLRRVSTQVKVLLDIASSLSDQPNGDGLRSPPIRSPLPSPRSDRQMSMPQPSAFAIQEELHKAIDLGNLLAQAVDLANEKIVKILKVRSEQAIHLPLDLFLRYFNLNLYFTYECEAISGRSCSALKTVVNSHIKEFVQKYRDAEMQKLAQGMESDQWGAKDFTDENTLLLNQILECSTHDIEAWTVSSRIWIPYESPRALSTDGGTSETNGASKEKVRNAVIESEKFVLPNSAVLCLDGMGDFLKLIAGIPSMTTEIATSLVAYLQLFNSRSFQLILGAGATRSAGLKNITTRHLALASQALVFIATLIPHVREYVRRQAGSGSNVSSLMGEFDKVRRLLQEHQDSIHQKLIEIMSGRAVNHAKSIRAINWDSDTSEGPHPYIEMLVKETTTLHRVLTKHLPETSIQVIMVPVFASYKNQLGDALRQAAVSTQAGQRRMIQDVDVFINKLQKIDGFGDAGEYLTSIVKSKKVEADSPPSPAPAPAPTTTSTAATNGTDEAKTADAESEKKTSSEETPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAL3</accession>
    <name>A0A2T4CAL3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pet127-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAL3"/>
    <dbReference type="STRING" id="983965.A0A2T4CAL3"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="961" mass="108313" checksum="297D843FD8D90ACB" modified="2018-07-18" version="1">MLQPFLRARPLAHPAALWAIRQQPLISIGLRSFAATQGPDANLSKKERIKRRREAKAQSKAKAKAKGSYLHKPKREKPSKDTPSGAAESGESGIAGKLAPDHGSEEAQKNAGDFHAAGAPPSAGTWTSLKSRLQSPALKRRARKAEEDGTEEEGVDVVKRDAERPVASARSADEKTSLDGRLGKGKRTKIKRGLNVKTIRPQHLQLCPVEEDSLVPVPQLCHDLNRVLFNPGVYHMQDVRSRVYNFDPYLASIMPVKEFDFDALRRYVTSSKDVKLRQLSASHGMKYCGSTSSMTSILSHFHYLLSAWRRPNFAFLSRSIEPESYNFTALSRGPAAAFAHYKDGTYAFDSDKEYDTENILSLLGKSMEKLLTLPKDEFEKYRRTKSHSLSEEERNAQDSFHYTTLGDFMMRSQLDAYDPRLPGSGMFDLKTRAVVSVRMDVRGYEKGAGYEIRKRFGQWESFEREYYDMIRTVFLKYSLQVRMGRMDGIFVAYHNTQRIFGFQYISLEEMDVALHGTSDRRLGDQEFKTSVALLNELMDRATKKYPGRTLRLHVETRPTKVPLTYFFVEPVTEEEMTITQEAGKSSVEELERELLTLSETENEEDPEGADSTAQVEPEQVDGEAKQLPNEASHKGTPNEAAWNVMMLKVEETVEDESLGIGSVREAVQEALEQSGLLNNKTELEIEQSLDAMVASLTAHSSKIKELRDRSDEPGQTTKPAAKRDAEDDDVSEEEEPADDKQSFEHGATGGESEAENASLADLILRATEGIDNQARNLKTFQRMFADLAVESKQPDTSSSEMRGKTPAADEELNEDELADEDEDDGDVEEPGQKDRELLGMYVTIRNQVNGEYVERPNINQEGDFDWSVEYTITELPDKRARKIYSKIKQRRRKVLAPQSSDGWDWYKMFQGKLPALAKKGQQFRELRTQQEANEPVHVAWEPTALPPDAFKPASGDGEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAP9</accession>
    <name>A0A2T4CAP9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1373380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAP9"/>
    <dbReference type="STRING" id="983965.A0A2T4CAP9"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF71">
        <property type="entry name" value="EPOXIDE HYDROLASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="462" mass="50704" checksum="D1DDFC20BF7E9ABA" modified="2018-07-18" version="1">MAQSTGEPANAAADGEIREYKIHASTKYMELTRQKLELARLPREIPDANSRTWWNPKPTLEPLIDYWLEHFRWKEHEREINQTVPQFKISFQISATEGPTRIHFIHARSRHPNAVPLLLIPPFPFSNLSFRHVTDVFTSPSDATADQPFHLVMPSLPGVGFSDSLPDGTPVIPKTSEMFDTLMKRLGYGHYLATNSGSSITPDGGVDWKVINHLAATYPNSCLGVHLISPPLKAPKALKSPVEWMKLTLAKTLQTPIGGYTREDIAALQKNEREGPKKSSATEFLPLGPFGAGAYDPNTLAFALCDSPTGLLVFFLAVFRALDSEKEYTNLELVTTTKLTWLPGPEGTLRLLADSYLSGEDAIPKPSRKPKASITVFLADDGAGPNGSSSAQQSATSRSASPYACPSWGRQHYDVVWTGRARGKQGLLAWERPQVIADGARNLAKALMAVDKRLQAPVNGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBI5</accession>
    <name>A0A2T4CBI5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1370426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBI5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBI5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32654" checksum="A93CA3735467769B" modified="2018-07-18" version="1">MAREHHLRRLLSSVSDESDDEESLPHHASEEKSTKKPRVSSLLVKPCSFLLILLTTCVLSFWAGTRVHGRQADVDRLCAKHTNHWSPLARDVPIKYTYQEFNGSFLKEDIYRKVGSAEVDKAWEELGSNYRAGVISYEDGLASGLDSSFVQRAEKHGGGFIVNVEGMHHLHCLNLVRKALYFNYDHYKELGEHAFTNEESILRLHITHCLDTIRQVLMCNVDTGVLGQVWVDPKEPTAFPDFSTKHVCKNYDDVRQWAERQQAPPPDKLPKDYLAPPKAGDVIEFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC08</accession>
    <name>A0A2T4CC08_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1398333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC08"/>
    <dbReference type="STRING" id="983965.A0A2T4CC08"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="894" mass="99931" checksum="3E0CC61C2919EC91" modified="2018-07-18" version="1">MATPAPLEDQARLLEDALVAVRQQTSLMRKCLDTPGKLMDALKCCSTLVSELRTSSLGPKQYYELYMAIFDALRFLAVHLRENHPVNHLADLYELVQYAGNIIPRLYLMVTVGTAYMSIPDAPVKELMKDMMDMSRGVQHPIRGLFLRYYMSGQARDYLPTGSGDGPEGNLNDSISFILTNFVEMNKLWVRLQHQGHSREREQRIRERKELQLLVGSNIVRLSQLVDLETYKTAILGPLLEQVVQCRDVLAQEYLLEVITQVFPDEFHLHTLDQFLGAVSRLNPHVNVKAIVSGLMDRLSEYAEREGGREKGPDQEKAEAEALAKLLEKVKLQNEEPEVAQPAASEQAPTEDAAGNDTKASAEAEQLPEEGEASAPPAASETDGAAAADATAPSVAETEATAVNGQEGLDAKDVPLYEVFFTQVKNLVEAQHLPIQDTIALLVSLCNLALNNYPDRLDYVDQILAYATTKTKENANNADLHSAAAQQSLLALLQAPLNRYVSIFTALSLPTYVPLFQAQSYPTRRAVAGGIIRGLLKDQVKITKPDQLEHVLDVLSVLIKEGTQAPQGYPGAAQRRSVETDETMEEQGWLARMVHLLQAEDNDTQFKLLQMTRKAFSEGNDRIRTTTPPLITASLKLARQFKRREHFDDNWETQINALYKFIHSAISTLYTRVNGAGVAELALRLFCWAGQTADLTGFEEVAYEFYAQAFTAYEESISDSKAQFQAVCVIATSLHQTRNFGKENYDTLITKCAQHGSKLLRKPDQCRAVYLASHLWWATPNAVNGETEETELYRDGKRVLECLQRALRVADSCMESATSIELFVEILDRYVYYYDQQNEAVTTKYLNGLIELIHSNVAGNQPDSASVEASKKHFHQTLENIKSRQYEGVVLYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC89</accession>
    <name>A0A2T4CC89_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mg-dependent DNase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1436503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC89"/>
    <dbReference type="STRING" id="983965.A0A2T4CC89"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43931" checksum="D16E0F8178CA512A" modified="2018-07-18" version="1">MNAPGSDSEPASEPYKPRYIDIGINLADPIYRGKHRGVQRHPDDLKDVISRAKEVGCTKLIVTGSDFTSARDALELAREFPGTCYATAGIHPCSSAIFCKGGHGRHDEHTTPCEPESSEPVEHKGEPDPETSAKVIDELTTLLAHARASSKHHLVAMGEFGLDYDRLHYCGKAAQLHSFEAQLKVAASLQPQLPLFLHSRAAHRDFVDLLKGAFGDKLERLEKGGVVHSFTGTIEEMKELMDLGLHIGVNGCSLKTEENLTMVKEITLDRIMLETDGPWCEVRPSHAGYQYLIEKKPEPEPQATNGEPQPADAAAQQQAKRPKKQKNQKKEPDVPSRFKVVKKEQWQQGAMIKGRNEPCTIERVAKIVAAVKGVSIEELCEASWRNTVNVFGLGEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD86</accession>
    <name>A0A2T4CD86_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1327489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD86"/>
    <dbReference type="STRING" id="983965.A0A2T4CD86"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001244">
        <property type="entry name" value="HCP-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="382" mass="41140" checksum="8DD8A250E72C9536" modified="2018-07-18" version="1">MGIRDALRKKDAINHDQGPEIFVRADSDSISQQFATAPDQGHEQAQEQGLGQGPPGFNDALLSPAASASGGEQRRSRRSFDFFHSSSERPRSPSASSATSQTKKESTARRLSHRLHLSRSPETSEHVPQNLPEIVVPGSDAGDREAEELQWEKRATMLAAGARSPADAAAHVSLDGAAARSRSASTHSATAPVSSKQIDADIQEAIRLHEEGNVAEATKLFGRLADENGANNPLSQVLYGLALRHGWGCTPDPERAVHYLTAAASNAAAVEEMALQAGLKKGGAAKGELVLAIFELANCFRNGWGIEKDPIAAKQYYETAANLGDTDAMNEVARCYLEGYGCKKDKYTAAQYFRLAEKAGNKTLGNSWIWKEKYDPGNGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDN1</accession>
    <name>A0A2T4CDN1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-DNL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1419973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDN1"/>
    <dbReference type="STRING" id="983965.A0A2T4CDN1"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="192" mass="21208" checksum="088E6A3B5F0F44E9" modified="2018-07-18" version="1">MASKSASQLFHLLRPSTLPKSSLRQLTTLPRPSQTTSRAILTTTTTTRRFAHAIPRPPSSSRKNLPSKEPSTAEPPASESHRPEHKGPAFYQLSFTCQPCGHRSHHNVSKQAYHHGSTLITCPGCRNRHVISDHLNIFGDRKITVEDLMREKGQLVKRGSLGEDGDIEFWPEEVVEQDVLAEGAQKKAGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDN8</accession>
    <name>A0A2T4CDN8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mis6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1177005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDN8"/>
    <dbReference type="STRING" id="983965.A0A2T4CDN8"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="717" mass="79612" checksum="546C180F205593F3" modified="2018-07-18" version="1">MSPSAAEEIDALIQAVSAASKLPAKSRGVNIKPTVASLASLAYENGLLPTALDKLVGLLVTPSHLDQASLNAIVRNLYPVARVSSDVVVRIIGALGHGTLKPSLTIQVALLKWLIMIHHVLETPAVLAQAYGVLFNLLDTAAIRPNVCHLLALITRRKHVKPFRIQALLTLSRQTANDPYLIGLLRVFKDYYPEIILGELVRGKASAFKHPDVAWKERLQEIQEAYALQAEKNTRGALDGFQVNRARGRGHGKRVVPSVHTSHVTENAITLEEIENATGFVRNMDRIELPNQLVAVLADPLLQKLLLLRPSAEAYQRISNWLSSVLQNVLDGDADEATLWEVLDVVREFVVQSKSIPPVFLEFFARFFQQWNGSGQRGYILQILSYAPLLDFQELYQHILQPLEAAVLDNTPGSLVDVLTLYTHLLHHWIAILQSSDAIPAHANTSLRALIRHTGQLSLTLLQTSPTESVDMAILEFYEQATYLVNDERLKDYIRIELPPSELIYIFLFGGSVTTVSRLCDILACYKKGFEMAMSTKARNDGSNRIDALSYDRAYVNLYNGYLMDICNCFWRSRAFSDADTNSHGCMMPRPAVSKLTSYVVSVDKTFSLASLFSLSYSPVLCLQSIQSVRDLEDAAITRDSSIRTRHAGPVTQASLTKLATLGGIQLSWQEYRIEVLRSLAEKNLGGIAELLKNTMTVLKKSMDATPRARAKMLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDW2</accession>
    <name>A0A2T4CDW2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDW2"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29658" checksum="254F7F73C25E1F03" modified="2018-07-18" version="1">MNHLAYFEALRHNLPKDAPTTPSTQTKSSPTSSSSSTPKVGFMSLPLELRFQIYTHLLTIPPPPSSSSSSSSKPQPPSHAALSATSPSPHEPSHIHPAILLTNRQINWEATPFLYSANIFIAHPSLLTTFPRLRNWYPPLREAKTLTPLIRRFHIQVRLDLPLPFDREKARDAFSGLDELSIDAVQAMFLGVDCTNLAVFELVRGVKRVSIGGSTTGFEGYIAWLVGAMTCPVGTEVAPYEPVCESPWAHLWSGHTNLVRSSAVQAEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE24</accession>
    <name>A0A2T4CE24_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1327315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE24"/>
    <dbReference type="STRING" id="983965.A0A2T4CE24"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015686899" evidence="7">
        <location>
            <begin position="21"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="427" mass="45025" checksum="995C4A1A961CE4E6" modified="2018-07-18" version="1">MLWKRLTAVLLLAAGRTALAQRSDDESICDYYAAQRYGESNMTTQLLLVQSIVTLAYAGGHEILPDADNGTTGIFNEGLYKGAGVYLRPWFDGSKATTNLNDQPVGIDWLDGGATGPLLSFLNGSTSSVEIDKSTNQYRLFTHWFTAFGFVYGCSSAPKFPRTGESRSGPLSPAYVHKFMDLNQTHIGYFIEQLTLASMAYGFSYEDAQTLSTFMNARYNVRCAPAINGQLFSICFADECPLAQPKPDCDAYKEIGPSGTGNGSQPTATAGPGSATSSATTTSNSPASTTAAAGDSGPSQASKPSSASLSAGAIAGIAIGGAAVLLLAVGLLLYFRRRSAKPHLVPVPVPSDGYGSPAHPTYSYYSSNPHMSMASSVPPEAYMGGHSPVPGFWAQPKPQEMGQNGHETTAASRPATMSPQIAEMESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEW9</accession>
    <name>A0A2T4CEW9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1435798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEW9"/>
    <dbReference type="STRING" id="983965.A0A2T4CEW9"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="461"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="700" mass="73475" checksum="2A7FF8D34FF03916" modified="2018-07-18" version="1">MPVTMGDPSANRATPSLLPSPPLSAAWGTSGGNIWAAAPLGGLHSVSMAEPSPQTGRYYAPAPVDEPQPAFGAASVQPSQGGFYPPLHVQHPAHQHAAPMLSFREQAKAAAPQPSPVHVMMQRLSPNTSAAEIRMMLVFSQELLSVDLIGPDPSEAEPQCSALLAFRSMNGASEACNKLNGRPNPSGHGTMMLSILSSSAYGSPAYESPTRASSAVPNGAPNRYADFLRMNHEPQPPHSNGVVSPTANAGRFFPAAGSGSGSGSGSAPASAAPAFAPGPAPVAAPYHQDFAAPNTQAGSRYKEIFDRQSSTGNYLPNEVPGRLGKHLINAEVGDEDDRELLRDSVAYGNRGTPVQRRDATITPPDSLSQAMSGLSLESNIALRSATMPAYLAGLPSAIGPNSIYSRLQEHVTRQQQQLHQQQQHHQPDKRSSRHSGRHQQGPYGGANYPPVNPADQNPPCNTLYVGNLPMDACEDELKILFSLTKGYRRMCFRIKHNGPMCFVEYEDIAHATKALTTLYGFPLHNSVKGGIRLSFSKNPLGVRSASSQPPHGNLYPSGGMRTPTANGFAAASGPPPGLPRPPGLSSRSQSNYSAGSRASSAMGPVLNGNGHGHGHGNRNGNVNGHRNGTLNGTLSGGVSEAGSSYSQRAPFYRTGMNGMNGVNGITNLNGMNSMMNNMNGMSGMNSMNGMSMATPHTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFI0</accession>
    <name>A0A2T4CFI0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_190735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFI0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="169" mass="18728" checksum="2E0F31F5EA985416" modified="2018-07-18" version="1">MRDFTHSPISNNIRKTGLSPYSPAELLPLVCCLLLALPSTPAARLSSASVASRLETEPSEKARGEKRVAASRQHLHHHDNRDRGFPAAALCACQLVFLLLKSHIYTLIFPQSSSRLAFSCSRLYISEFPPSLLNFSSSHLLFASHLFFPAYMNRNLSSHLSLSTSFVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFX9</accession>
    <name>A0A2T4CFX9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFX9"/>
    <dbReference type="STRING" id="983965.A0A2T4CFX9"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF34">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G07820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="159"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="349" mass="39486" checksum="C5B75E7531B7B088" modified="2018-07-18" version="1">MRITAIWVYPIKSLRGIPLHNAHLGPQGIKHDRRFMLWRVGESGELSKIQLDRYPECSRFAQEIVGDEIHVRYQPPSEPLVPPSPEQSVVLSVPLDPDVSRLDRQVVNLHQGMVNGYRMGAAYDEWFTACFGFPVVLVYIGDERRPVLGTFSPRAQPISPPTQQGWLSYLYSYVWGARQQPEPEPDWLTFSDMAAYLVASEKSLANVNARLSSGPVDIVRFRPNIVVDGDGEGAFDEDFWAELSVRGRPALAMTKMCNRCTSLNVDYETGRFGEGDNGAVLKRLMSDRRVDKGSKWTPVFGKYGFLVDGLDGLDVAVGDEVEVTKRTGERPVWDWQYKDSSIARFYRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGP3</accession>
    <name>A0A2T4CGP3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Seven transmembrane receptor, rhodopsin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1133813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGP3"/>
    <dbReference type="STRING" id="983965.A0A2T4CGP3"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="577" mass="64678" checksum="13144E2825D5FA7C" modified="2018-07-18" version="1">MPDHGTGQKFTTATTVVAGVASIVATVLSVISIWLQAKNYRKPLLQRYVVRILLMVPIYSIASWTSMVSLRAAAFVDPIRDIYEAFTIYTFFQLLINYLGGERAVIIMTHGRAPVHHLWPMNHFLPKVDISDPHTFLAIKRGILQYAWLKPILALAAIIMKATGTYQEGYIGAKSGYFWSGIIYNISVTVSLYSLGLFWVCMHRDLIPFRPVPKFLCIKLIIFASYWQGFFLSILVWLGAIPDDVQGYTRDNLAAAIQDALICVEMPIFAVAHWYAFSWHDFADNRIQSARMPLNYAIRDAFGIKDLIEDSKETFRGDKYGYRIFDSGDRIMAHEDSRSRIARLQEGMRYERGGKGKYWIPKPGEVNATSPLLGNGNGNGASSSARVDQLNENTHGTFEEPEIDPDEDHLYAKARQLEFGDWNYPVITASEPLRERYASWASSSETRIRSSPPQQGRSNSNVASSAHTSHQQGQHTDSEQPAPVVVVKKKKKKSKKAAAQPEPAPADSPATPDREAQSSTKATAAASSQGYDGYQSLAAEDHDEPWASAEHEDERRHTPSYQVSDSDEFRNVWDGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGS5</accession>
    <name>A0A2T4CGS5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1370267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGS5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGS5"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="287" mass="29790" checksum="0286E4026E04FAA2" modified="2018-07-18" version="1">MATPTSTSAAALIESAKKAAAYQAVADHLPPTATYVGIGSGSTVVYVVEAIAAKGPAFSANMTFIPTGSQSKGLIRAAGLRLCNLDERPLVDGVPVALDVAFDGADEVDEELNLIKGGGACLFQEKLVAVAARKFIAVADSRKQSARLCTKWKTIPIEVLPLAAPDVLSRLKAMGSPSPVVRSGLPSKAGECVTDNGMWIVDAPFPPLLLPKDLTADVKGAGENGGVWEIGRLAEELVRLPGVVEIGLFHGFNGVQAVSRGKEFQAQKPVAAYFGTPTGEVQVQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGV5</accession>
    <name>A0A2T4CGV5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_46720</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="5"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CGV5"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="725"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB80773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1459" mass="160149" checksum="4A30EEEC7D97E012" modified="2018-07-18" version="1">MATSTQIRTPEEAAARIAYLASDVVISVQPSLAADSEFSSHLKRFSGRKDRGIVAATEDTVPEIQYVRYNNDPLLSVFAPARSGKLVSVTTPSSIILPSISHLYKLVNYPVVLHVALQPRGFADYSVITSIRNSGWTFLQSETLQEAQDMAITAHALAVRTGKAVIHFFSPDTSARDEPIGLEDFSVVRAVLDIDTVRRLQAGTIKASGLYADDGHVAVSSDHQEAESSGSADKPSGLQASTASLASKVVSELSAKTSQASSSSTPTGSSSVATTVEIAAPQVTSEDVYVCATRIWAQLNTALGRQYNAFEYTGSANAENCLFIFGSDTRSFAEAIQNAKPDDVYAKIGILTARLYRPWIGSKLVASIPRTIKRIAVLEQIHRKTTKWGPLLIDVLSSVKSGPGGVETIVGHQLGYIAPEATTQALRGVVQNLTAAQPIQNLEVGVKEGPSEPAAAGVDAPKLEVAYSKILDQLFGSRTYIANALQSQNAGISPTVAASPEFGFGSLLARKELRNRFVAEVKQAASSSGVASEALKSWLARWAVNADDQAKSDIISDDVIAKLEQDGSPEAQKLLANRHLFRKESLWLMGSDAWAYDLGNSGVHHFNGPSVVLAYLPYFGETDSPLTVLQETKKAVDAGYWPLYRWNPDNEAKGEPTFSLDSELVKQELKAFLARDNQLTQIMKKEPSFAASLGQDFGTEVRAAQKRKAKDAYNQLLEGLLGAPLTILYASDNGNGSTLAKRLANRGRARGLKTAAMAMEDYPIEDLPTEENIVFITSTAGQGEFPQNGLAFWDAIKDNTDLDLATVNYSVFGLGDSHYWPRKEDKIFYNKPAKDLDRVLGNLGGKRFVDIGLGDDQDPDGFQTGYAEWEPKLWQALGVDKVEGLPDEPPPITNEDIKLESNFLRGTIAEELKDTSTGAISAANSQLTKFHGTYLQDDRDVRDERKAQGLEPAYSFMVRCRLPGGVATAAQWLQMDDISSKLGNETMKLTTRQTFQFHGVVKGKLRPTMQAINRALMTTIAACGDVNRNVMCSSLPAQAKLHEQVQSYAAKISNHLLPSTNAYHEIWLADENDKKVQVAGDAVQDFEPLYGPTYLPRKFKITIAVPPHNDTDVYAHDIGLIAIVGENGELEGFNVLAGGGMGATHNNKKTYPQTGRMFGYVAKEDVHIACEKIMLVQRDHGDRKNRKHARLKYTIDDMGVEVFKGKVEELWGSRFDKPRAFEFKSNVDTFGWQRDEFGLNHFTFFIENGRIEDTPDFQMKTGLREIAKVHKGEFRLTGNQHLILSNVSDEDLPAMKELMKKYKLDNVQFSALRLSSSACVAFPTCGLAMAESERYLPVLITKLENCLEENGLRQDSIVMRMTGCPNGCARPWLAEVAFVGKAYGAYNMYLGGGYHGQRLNKLYRASIKEDEILAIMRPLLKRYALERTEGERFGDFCVRVGLIHETTDGQNFHDNVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH93</accession>
    <name>A0A2T4CH93_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH93"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="81" mass="8687" checksum="5A0B2E192AF5798B" modified="2018-07-18" version="1">MSPQGASSAAQKQSLSAAALSVSMPFSLSSLGMLPGEMPLSCNKCHDCTEYHSIAGIDSRYQDSEWPRCMQGAFARETRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHB4</accession>
    <name>A0A2T4CHB4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1322381</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHB4"/>
    <dbReference type="STRING" id="983965.A0A2T4CHB4"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB80936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="593" mass="64450" checksum="65BD8EF23E25BC97" modified="2018-07-18" version="1">MTTTTTTPTSSSSLRFSPGRRLGSARSYSGSSSTRTTDNDGDDGVGAFEQQRKRAGGLPADANVAVLGGGLTGLTTAYYLAKWLPPTAKITLLEASDRLGGWIKTDRVPVKVGGVEGVVSFERGPRSLSSLNKSTWRFDDLVLWDLALDLGLKVASPPDKPRYIYYPDHLVPLPPHTSLTAFASEPLVLESLWAGFGYVLRRLFSRKVGVPVQDLSIADWIQHITGSRAVAENLASAMVHGIYGGDIYTLSARSVLDRFYWVHYLPALGPNVRHMALSEQAFMEAMGQDPLIRKLAQQPRGALLNFGAAGMETLPVALADALNGQANVEVKLGAKVTGLEYESETEMMKITTTGQDSSPKKYHKVISTLPSQHLARITDALPSLASSHAVSIMTVNIWYPQTNLKPPGFGYLIPLSVPAEQNPERALGVFFDSDVGVRGPDEPAGTKLFVLMGGHYYDKKKQAGASVPVPSEEEAVQQAKRLLERHLGIPQSTPCFAMARLARECIPQYVCGHQDTMAAADEDLRDSFDGRLAVAGGSYTRIGAMGALRNGYEIANTVVREDWLTTGLEQLEFPTQFCGVPTERIPVRRFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHB7</accession>
    <name>A0A2T4CHB7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_63100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHB7"/>
    <dbReference type="STRING" id="983965.A0A2T4CHB7"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="717" mass="80755" checksum="466E2F0751D25357" modified="2018-07-18" version="1">MGLLALGTALEWPEAKLRANQVREWGIRQLLEIWNKAKGKERDAMLWGDEVEYLVVMYSKDDPKVLLSLRQAEILKALSINEALAEAGSVPALQDENPAAKPNKNSGALPVFHPEFGRFMLEATPGKPWGIGLKELLGVEPDMKLRRKIAKEHMLSTEYPITLTTFPQIGVPGQFTHPFYPPSGPKLRSQFVPDEIANPHIRFPTLAANIRARRTRKVQVNVPIFRDKNTPIPWKDPTVNYDLHNWPEDDDVRNGAAPDNFIHMDAMAFGMGSCCLQITFQAKNIVEGRELYDQLSPLGPIMLALTAATPIYKGFVAGTDVRWNQISRSVDCRTPEELGEKPLKHDRWRIPKSRYAPNSTYISTNPRLRPEYLDPNLVFDPDLKAKLIEGGMDDLLATHFAHLFIRDPIVIFEEDLQELDLTKTDHFENIQSTNWQHMRFKPPPADNNIGWRVEFRSMEIQVTDFENAAFSVFMVLITRAILSFDLNFYIPIKKVDENMERAHGIDAVLKDKFYFRKNPFPPRPSRANTVFNDDSRPGSAMPSRPGSPGSLPPVEDEYTEMTINEIINGSPDGDFPGLIPIVESYLDSVNVDVQTRCELATYLSLISKRASGELDTAARWIRNFVDAHPNYKHDSVVDDVITHDLIGHVVAIGERESTGRGFAGLDVPGLSKFLGNFRARCREVNAPDAGENGEEADRVSRKRKSEWIDGATAEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHS1</accession>
    <name>A0A2T4CHS1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_76763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHS1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="97" mass="11179" checksum="3D21612F984927C0" modified="2018-07-18" version="1">MSWRRAWKKREGRVPPRDSILMPSALAISHSSIPPSPLENEHHRDRRQCLRTCTSTHMPCWAWSRFGRGRVDAQRTSLDSTRLIGPLPDSLLHVHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHV1</accession>
    <name>A0A2T4CHV1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1435002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHV1"/>
    <dbReference type="STRING" id="983965.A0A2T4CHV1"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27681" checksum="2C2C06F60DD14D28" modified="2018-07-18" version="1">MAAARGTGDAWLPSSLEAARIASLPSTAYYLPNFISEEEERLILDKIAAAPRPRWKQLTHRRLQTWPSDLVNNKLLDAPLPAWLETPIVPRLLSLPLPDDGDSRKHIFAESPHQRPNHVLINEYPPGIGIMPHKLSTMANLGASLCLNLYRSKEDGALDPEPAWRILQEPRSLLITTDTLYTDYLHGIADAEEDLDLSADTIVNWPLLRDPEAFAGGRNPRQTRTSLTYRDVLQVSKAGAKLGLFGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI43</accession>
    <name>A0A2T4CI43_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1321781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI43"/>
    <dbReference type="STRING" id="983965.A0A2T4CI43"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="245" mass="26760" checksum="3C630B4F1D26D5F8" modified="2018-07-18" version="1">MKLIVVGSSGFVGKEVVRQALANPAVTSIVGLSRRETPVPESLEGSSDADKFTSVVVDDFMNYSDTVKQHLANADACIWLMAVTPNKSASMPWDQVRKVCLDYTIHGLEELSKARRNDTSKPLTFIYVSGANAERDPAKKPWLLGEYCIMRGEVEARVLGFAKNSNNAIEACIVKPGFIRDAEHGSFLLNAFQNALSGVIRVPVNYLHDVAATLLAQALEGFEKQTLECADIARIGSSKKQDVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIB0</accession>
    <name>A0A2T4CIB0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1417982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIB0"/>
    <dbReference type="STRING" id="983965.A0A2T4CIB0"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="144" mass="16380" checksum="E03D495AA06E8FA5" modified="2018-07-18" version="1">MIFIITILLLAADFYYLKNIAGRRLVGLRWWNEVDPQTGESQWVFESLEPGTRQINPTDSRFFWLALYVQPLWWVLMAVLALIRLQFLWLPLVAIALALTIINTLAFSRCDKFSQASNFAGGAFGSTNLAGSIASNFVSRMFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ94</accession>
    <name>A0A2T4CJ94_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_89599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ94"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="16201" checksum="0615B4B6DC0DC040" modified="2018-07-18" version="1">MSGFSRCPPKTTHVSSRIGRQFAAFHMAGNAEFVLTIHGPELLGQSACVRHSGVPCVCRRGKGTLFSSFGRLAETDSTIRATLLFCACLRPLGAVTTGCLSRTTAGLGSCKHPGHALANAVCLNVRCPGPGIPLDRSWSVSIRGSRYKAAATDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJA3</accession>
    <name>A0A2T4CJA3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1435332</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJA3"/>
    <dbReference type="STRING" id="983965.A0A2T4CJA3"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="118"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="733"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="17">
        <location>
            <begin position="945"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="950"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB81588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114355" checksum="50A27ECEB37DF76D" modified="2018-07-18" version="1">MATNSARGIPIPGTEGIQESTTAPPNVSAEVKQEVAASTQSAAPGEHASGQDAGVVPAPEGPQKVKSEKELEKERKKAEKAAKLEAKKAKAAAAAAAPTKEKKAKKEKVEEEPLPPYDLMIRWNRMQGKTTLWVPGCDHAGISTQSVVENMLWRRKQQTRHDLGREKFVQTVWEWKEDYHKRINKALTSLGSSFDWSREAFTMDPNLTKAVNETFVRLHEDGIIYRANRLVNWCTQLNTALSNLEVKNKELTGRTLLDVPGYDKKVEFGVIVHFKYPIEGSDETVEVATTRIETMLGDTGIAVHPKDARYTHLVGKYAVHPFIEGRKLPIIADEYVDMEFGTGAVKLTPAHDPNDFNLGQKHNLEFINILTDNGLMNENAGPYQGQKRFDVRYAIQDALKEKGLYVDKKDNPMTVPLCERSKDIIEPIIKPQWWVRTKELAQEALRVVKEGEIKIRPESAEKSYYRWLEDINDWCISRQLWWGHRCPAYFAKIEGGSDDIPEEKLWFSGRNKEEAEKKAQAALPGKTFTLEQDEDVLDTWFSSGLWPFSTLGWPEKTLDFEKLFPTSVLETGWDILFFWIARMIMLSLKLTGQVPFKEVYCHSLVRDSEGRKMSKSLGNVIDPLDVIAGIKLEDLHAKLLQGNLHPSEVQKATKYQKSAFPDGIPECGADALRFTMINATTGGGDINLEIKIIHGYRKFCNKIFQATKYVLGSLPKDFVPSKTGAVPGKTLAERWILHKMNQAAKEINIALAEREFSKSSIIVYRYWYNELCDVYIENSKAIIRDGTEEERNSAIQTLYTALEAALTMIHPFMPFITEEMWQRMPRRPSDETKSIMVAKYPTYNPALDDPASEQAYELVLDCSKASRSLMAEYAIKEDAEIVIQAYNAEALKTCQNEVTSIKSLSGKSVKTLQVVGPEASRPLGSVAYPVSTAASVFLHVKGRVDMDAEIAKAQKKLEKTGANIQKQEKLLADPGYKEKVSAAVQEGDLKRLADAKQEKHHLEETIKQFEQLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJE6</accession>
    <name>A0A2T4CJE6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1427527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJE6"/>
    <dbReference type="STRING" id="983965.A0A2T4CJE6"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="488" mass="55131" checksum="914AC04D4ACE0DE2" modified="2018-07-18" version="1">MFSFFSGQPQAPPRVPTDVVVPVGFFDDTIIFRTFILYTLFVFDDVLDPEKLRTSLERVVSRPGWKKLGARLRKNDRGELEHHIPASFSPDRPAVGFDHVNHGDLAVEDHPAASHIPRPPRNGRPALVGDPDKLSDLIYGPEVPTKLDDYIYSDRPQLGLRVVSFKNSTVVVLHWIHLAFDATAKRALLDAWMLMLQGREDEIPEPLAPDEYILENVGKNPTKPHVLAQHHVSKPGLVWWALQNSYNLIIRKKEHRMLCMPAEYLEKLRVKAVAELAAQAPPNDEKWEPPFLSEGDVLLAWVSRLAICNLPENSERPIAVQQAYQWRPILKDLIPENRPFLSNCVGFLVTLMPAKEMLQKPLSYLASQIRRSIKEQGSREQVEAYTSLVRLDPANRAPPFFGSSSMQLLMFSNWQKANMYGTDLSAAAVTPRSTPLTPSYVQSVQGPYSFNDGIIIVGKDAEGNYWLSGNRGQGLWGMMEKKMQEEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJK9</accession>
    <name>A0A2T4CJK9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1396930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJK9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJK9"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="299" mass="33767" checksum="80CD7ECFF03E3384" modified="2018-07-18" version="1">MARKLRDSKAFRACHWLVATRSRRRALFRAAIAALIFPVLLQWFLAYIVGSDARLLPPELLRAKNLLVVTAHPDDECLFFSPTILGILDRNRAVNGGLLVMSTGNNYGKGDTRKQELKGSCQALGINPSRCEAFNHPRLQDNPKVWWDTALIHSIVREYVKRWDVDAIITFDEGGVSGHINHRAVSAAVSEYVTSTKDAPPAYKLVTTGVLRKYTFLFDLPLTALSFFWRIVSAAFYPSVKADPEVTSKALLANSLHRYALTRAAFASHGSQYTWDRHLYMILSRYVWFNDLRRIPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJP5</accession>
    <name>A0A2T4CJP5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1323357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJP5"/>
    <dbReference type="STRING" id="983965.A0A2T4CJP5"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF10">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="307" mass="34475" checksum="42E4FD6AC032C154" modified="2018-07-18" version="1">MHQTGQSSKVDTWKPEVIPWVEQWLEYAASPDSASAAMAYFFWDDEGIDMFMNAYEKDFMGDFKSVFMPVERTDIFRILACRYLGGIYADIDTQPLRPPATWIGPADLAPWTDDLTNKTHSHDAATVNLIWGIEADTDPASDAYWRMGYTYPVQLTQWALASSPGHPALGLFMENLRAEVRLEKKEAAGGGNSRADPLTRTGPAAVTRATMQWLEREVQDFRWDSLTGLHDGGRSKLVQDVLILPITGFSPGRGSYGNMGSKPITHPDARLVHHALGSWKKFDWTVEYGKFCRTAFGLCRDWTKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJT3</accession>
    <name>A0A2T4CJT3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJT3"/>
    <dbReference type="STRING" id="983965.A0A2T4CJT3"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="89" mass="9860" checksum="51BB0120C70BE1E6" modified="2018-07-18" version="1" fragment="single">VLPAALKKYQINAPWDQYALYIVYGDQERCLGMDEKPLILFKQLDKEGKKPMFMLRKTNSAQVDGDIPGMSMNPARGAATGYDPPGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPG8</accession>
    <name>A0A2T4BPG8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1426697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPG8"/>
    <dbReference type="STRING" id="983965.A0A2T4BPG8"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="581"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="774"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="837" mass="91040" checksum="3A5270A8CB2715AD" modified="2018-07-18" version="1">MSGTSSGASTTAGYTPASVPDIKHQEQDKGTHRHEDPFTGSDSVFSHLASSNPLDVPPTASEWLHDQLPSQDEAVGYLMSLFPCISWLPHYNFQWLAGDAVAGITAGAVLVPQGMAYALLANLPPQYGLYSSFVGPLTYWIFGTSKDISLGPVAVLSTVVGTVVADMGMSNGDIPPNVVATGFSVIAGSLVLLIGILRLGWLIDLIPIISLSAFMTGSAITICASQLPSLFGITSFSNRDAAYRVIVNTLKHLPEARLDAAIGLTALSFLYLIRFSLGRAAERWPSNKRGIFFLNTMRTVFVIILCTMVSWVINKDRKEQPAIRVLGVVPRGFECIGLPRMPSTIMSRLCSHLPAAVIVMIVEHIAISKSFGRVNNYTVDPSQEMVAIGMANLLGTFFGAYSSTGSFSRTAIQSKAGVRTPASGLISAIVVLLAAYFLTAVFFYIPNAVLAAVIIHAVGDLITPPSTIRQFWRVSPLEVFIFFIGVFLSIFSQIEDGLYATVGISALVLLYRILKARGRFLGQVKVHSVLGDHVIGDNHRQLVGRYGTFEETAEIAARNLFLPLDHDDGSNPEVELGNPYPGIFIYRFTEGLNYPSANYALEYLTNYIYSHTRRSTPETFERKGDRPWSSLEQQTSGKLRAEPSLERKPTLKAIILDFSSVNIADITSVQRLIDVRNVLDVYAAPDVVDWHFACINNRWTKRALAAGGFGTPAPPQVGVPHRWKSIFSVAEIGGRDSAAAVAEANTLKQEPFAPDDRLGDEEAAQTVAIVESWEEEDRALTPRDQEEKPGEAPKPAHKRKGVIVSGSAYPLFHVDLTSAVQSAIANVEARLEVRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPI9</accession>
    <name>A0A2T4BPI9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1344752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPI9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPI9"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="63"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="314" mass="35439" checksum="2547C87881D41DD5" modified="2018-07-18" version="1">MSLKRSVSVDTTSSDSKRPRLASLEDQNSGEQQPGTTQVRTEEDVFPGWVDEAVPSLTPTVHHFARSGIQRSIALVLAHDGFQSATPEALESFTELVEQYMSSIMGEVKRLAIASRREHPIPTDYETVLKYHNISVSSLKPHVKNRLYNQDATDRSPVATTSDDTFTSLPLLGPELSGQHDKESKPYIPASFPGFPSTHTYKFTPQDDRRTREAKQIREDAAKSAQLGEDALRRLVRASKMRKQKEVKSLVERDSHGKERFRLWESTMRRFMGGDRFREHADKVDIADHSMIVNADARFARREVSRLGKKSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPJ2</accession>
    <name>A0A2T4BPJ2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPJ2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8189" checksum="9B4F1F9802996BB6" modified="2018-07-18" version="1">MSFRFVPPFCLTLTSRQAQAALHKSNSAVNACAAGDAAEGEEENDHSSTALALVREPLTDSSLSHPPSTSHARLGILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQQ7</accession>
    <name>A0A2T4BQQ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1406385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BQQ7"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="18772" checksum="95CAFD3D777A6B4B" modified="2018-07-18" version="1">MSGSASSGEGSNNRSMQSRTGRSKQRYNAQGERLVAGVVPLSADRNRVILIQSTRRKGWVLPKGGWESDESCQESAVREAWEEAGITVNIEHDLGNFEEKRPPKTSKDRSRYYFYQGTVLDQLDDWPEKDKRERGWFTYSQAIEVLVNRPELQEALNRSSMNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQT5</accession>
    <name>A0A2T4BQT5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-phosphate pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1145070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQT5"/>
    <dbReference type="STRING" id="983965.A0A2T4BQT5"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="435" mass="47338" checksum="5750F2BD4118F093" modified="2018-07-18" version="1">MVRNIVVLGGNSHPQMTENVCNFLGIPACNRILSKFSGGESRCEIKDSVRGKDVYIIQSGSGHVNDNLIDLCIMISACKIGSAKRVTAVVPLFPYSRQPDWPYNKAGAPLSKSSEFAKKDYTFESVPPTPRPGGPRSAGLANGVNGLTEKLTKNPGAEANGDAAPKRSDTLSSVSSASKDNNNNNGVYPDLTQRSFTTHDYENLTNISGFRPKPGYKQWVAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGKFLLQNYIQTHIPDFREAVIVSPDAGGAKRATAIADSLNMDFALIHKERRPIKFTDHRNASMMLVGDIANRVCILVDDLADTANTITRAAKLLKREGATKVYALITHGVFSGDSIARVNASAIDKIVVTNSVPQEEHRRLCPKLEVLDISPVFAEAIRRVHHGESISALFQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR70</accession>
    <name>A0A2T4BR70_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbohydrate-binding module family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1434173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR70"/>
    <dbReference type="STRING" id="983965.A0A2T4BR70"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015400171" evidence="7">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="8">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="410" mass="42473" checksum="50C06D0A8082CE60" modified="2018-07-18" version="1">MFFTKVVGGLGLLASLASSAPNPIARRQAPGALNVVYWGQNGGGTGENNDLSAYCTPTSGIDIIVLSFLYQWGQGSSALGGTIGQSCGITTSGQPQNCDALTKAITACKNAGVKIILSLGGASAYSSFQTADQAAQAGQYLWNAYGGGSGVTRPLGNNVVDGWDLDIETATNSENYAALVSALRSNFASDPSRQYVISGAPQCPLPEPNMGVIIQNAQFDYLWVQFYNNNEYPGDPCSLGLPGDAPFNFNNWTTFIQSTPSKDAKVFVGVPAAPLAANGAPSGEVYYATPAQLAGIVNDVKSNPAFGGIMMWSAGFSDSNVNDGCNYAQEAKNILLTGSPCSSGPVSVSRSPIPSPTITSSPPGTSQTPPSQTGSVPQWGQCGGNGYTGPTQCVAPYKCVATSEWWSQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR97</accession>
    <name>A0A2T4BR97_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1343185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR97"/>
    <dbReference type="STRING" id="983965.A0A2T4BR97"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF39">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="713" mass="79049" checksum="9A70C039833D494B" modified="2018-07-18" version="1">MQLDNSDGRRPSSTQRLPVNPRRHKVAPEQRKRVATACNNCNVRRVKCSGGNPCGQCSASNRECVYPTPVEKVSVPRTELEELRRKVDAYERALQEVIPDPSRRQELISQAAATPEGLSPSPSPFSPGQAYSPESSRRLAAPSVKAEPDDEQTTGRLLQDPDGTARYLGETSGATFLDHLKELLGAVLPLAQVEPQLSQDQDGTAFLNSLGRYYTADSRPLVEREETSLPCNEDLATLLCKLRYLIQDGNGEWPSGGIYWFGDLDAVPSQIASPPSASDADMNEYRHLAFYHAALANITRANTSSQEVHGSASTPSLSEAYFARAALLVGNPLDITRCCTIGDVATLCLMAAYLIEMNRRDAAYMHVAAAMHICIMLGVHRGLVDERGKRVFWTAYVLDRWLSCLMGRPHIIMDDAIRLQLPVDAPSMPPAAGLKAHVELSRISGYVVCNTYRVAPWEASRGGLAKQPDKAIWMLQQWQLTLPPRLQLSPDGLSNDPACCLLHMRYNMLLILAIRPLFLGAVKRSVARRLVVQTAEPSSAHTEHLKLCIAAARRNIRLGRQLTTLNISRKSPLHAEQHYSFNATVCLILEDLISDDEVSEEEREARNNDILFGIELEEDGLTNFGQTSSNTLRHLWTLARRLTGSMAQTQELNNARMAELQLAPPMLTTLGGYPSMPRMQIGEDHALYDELVAWVDDEWSIYNTGLFNNGFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRB8</accession>
    <name>A0A2T4BRB8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1406127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRB8"/>
    <dbReference type="STRING" id="983965.A0A2T4BRB8"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12030">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12020">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056778">
        <property type="entry name" value="UPF0261_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002674">
        <property type="entry name" value="PRK02399.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23189">
        <property type="entry name" value="UPF0261_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0261" evidence="2">
        <location>
            <begin position="196"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="421" mass="44846" checksum="B18CC5BA4612390F" modified="2018-07-18" version="1">MASVAIIGTCDTKLKELLFLRDRIRETSGVKTILIDVGRNPCADDAITISQAELLSKYNDGNSTDKPDLTRGDFVSLMSGCASRAVKDLYGKGLIHGILSAGGSCNTALSSAVMRDVLPVGFPKLIVSTMASGDTRCIVGDSDILLQHSVVDVAGLNPILRDILSNAGTAIANIAVSYAARQEKKAKDAGTEARSKWRVGMSMFGVTTPGVNAIRSHLESNYPVETYVFHAVGTGGRAMERLIREGQLDAVIDLTTTEICDHLFGGVLSAGEGRLDAAVEAGLPSIVSLGALDMVNFGPRSTLPEKHEGRVIHEHNPNVTLLRTSPDECREIGEFIAKKLRKSKDPDLIQVWIPKGGVSMLSVPGGPFEDKEADEALFEAVKKGLSGSGIEIVEDERHVNDEGFARDIAEALVAKLGVQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRD1</accession>
    <name>A0A2T4BRD1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Late endosomal/lysosomal adaptor and MAPK and MTOR activator-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_68624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRD1"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17565" checksum="9543FBD6D6A6612F" modified="2018-07-18" version="1">MGLCQSCLGGRQKDVYDETEENRLLYDDGNGMQYGSFGDGTLNGEGDTAEAQRENEALQRVVAKTSNNMVDIFEIAPQDSTGRKSTTTLFAYAGQGARVARYHHLVSKLSTQEDSPPAGIKVDWLADEDASETHGNRPASLRTLEEDDAALVGTFADAAAAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT27</accession>
    <name>A0A2T4BT27_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_157535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT27"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="75" mass="8173" checksum="08033EA68BD0AC1A" modified="2018-07-18" version="1">MNCFAVTVTVPVTRCVFIRLHSSMAGLLASAYPSTCHEGVPTSRISSCVRIEQSVSHHGVSLQVCCYMPQAHHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTM8</accession>
    <name>A0A2T4BTM8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1465339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTM8"/>
    <dbReference type="OrthoDB" id="3211582at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="142" mass="15750" checksum="E4F00B91DC45FDF1" modified="2018-07-18" version="1">MPFFSRREPSPEPVYHPEPAAEPPSRKHSLFHRNRDRDVSPLSSQRAGSVASSSGGNPGAVNKRDSSGGLIVQAREHVMQAEAAEVEADRALGEARMRVRAAKDHVWRLEEEAKEEARRAKLKQEQAREVSKRGKGLGRHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU53</accession>
    <name>A0A2T4BU53_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quinate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1405286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU53"/>
    <dbReference type="STRING" id="983965.A0A2T4BU53"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="4">
        <location>
            <begin position="519"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="3">
        <location>
            <begin position="661"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="5">
        <location>
            <begin position="802"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="859" mass="94732" checksum="0C4A960D3ED23EC0" modified="2018-07-18" version="1">MAGVKRPLATMTGATEEPLTVGRRLKYCTLTSVSSEPENISRTPTPPNPFARARIPDFSSDASLVLVGLRGSGKSTLAIMAASALKKSIINVEAAFQSSTGSSSSSFRQSNGNVECQRRQAAVLQEVLEQNPTGCIIVCPWMERKVQSLLRQFAATNPVVHVLRDIGAIQGHLKIKDWSKAHNLMQMSNLFYRSCTNLEFFNVSEVRETSFEGNEADHQGLTANAPYLALKPAERHFLKFLSLVYPAGTIPFFESAFPLASIAPEHRQFTYCLSVHIQDVLSGIQDWEDSIVGIDAVQVFVNTLATSGESLTSVDELANKIAEAVGIVRRSTMLPILLHIKLPETPNNRVIRSYLDLLSQALSLAPEMLTVDLRLDHSDLSSIISAKRRSKIVGNYSVSTDTQPWDSPAWISWYHKACQLGCDLVRLVREAKTMEDNFQISQLKSKLSSLKGYKLPLIAYNCGHLGRHSACFNQILTLVAPRPVAQADERSAPFPYITAKEATNALYASFVYDAMNLYVFGANVGYSMSPAMHNAALSACGIPHRYEPYSSESLKGVAHLIYDPHFGGASIGLPFKVEVTTLTKYLSPHARAIGAANTLIPIRQLKPDGTIPTGSALLAGVNRAGPVLALYGENTDWIGIRACIRRGLSPANAVRQTTWGFVIGAGGMARAAVYAMLQVGIKNIAIYNRTTANAEKLVSHFQQLLEEKQHNPLANTHDIRFHMFASLEEPWPTEYRHPSVIISCIPTHPIGNTPSPEFRMPDAWLSHQTGGVIIELGYKTLNTPLLKQAREGASRGWVAMDGLDLLPEQGCAQFELFTGRRAPRRVMRREVLEKYRDEHGQSHLEELQHRLRSIVEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV36</accession>
    <name>A0A2T4BV36_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1441409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cell membrane</location>
            <topology evidence="1 5">Lipid-anchor</topology>
            <topology evidence="1 5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV36"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF8">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015369894" description="1,3-beta-glucanosyltransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="457" mass="49095" checksum="97D2971FB0ECDA14" modified="2018-07-18" version="1">MRWSSVAVALASAKSFAAALDPVSVVGNKFFNKDGSQFFIKGIAYQLVPQDPLVDTDQCKRDAKLMAELGTNTIRVYHVDPDADHDGCMSAFDDAGIYVLADLDTFDTYIIPQNNYWNKTKFDRYAEVLDTFQKYDNLLGVFVGNENIATKDDSPTAPYLKAAARDMKAYRDAQGYREIPVGYSAADILQLRPMLQDYLTCGGNSSETVDFFALNSYSWCDPSNYKESTYDQLESYAKNFPVPIFLSETGCIVPGPRQFDDQDAIFGPDMVNDWSGAIIYEWIQEENGYGIITYAPAGQAPGPNVEGGFLRKGTPTPKLPDFTALKSKWATNTPTGVSRADYNADDVSTRACPSSTAGGWWQVDGDAKLPTLGQILAVKTETGSLATETGTSTAESTSDSTSDGSTGAATTSKPDSSSSTTSSADSAETSNGSPLDKRVTAFGAGLVGVVLGAAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV46</accession>
    <name>A0A2T4BV46_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1074863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV46"/>
    <dbReference type="STRING" id="983965.A0A2T4BV46"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="221"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="644" mass="72707" checksum="AFC91FA7EE9BE99A" modified="2018-07-18" version="1">MNNQLHSSPPSPPTTSPSTTSPTSPDLEQHPQHLAVLPPAAKDAAGSLAPAASVANAVRLMNDLTDTPPYSRSVTSTAPSSPRIPPLRQNSGSQTPRVRPHATTLNIPGMTRSKVSPDGRIPQRDVAAKLVIVMVGLPARGKSYITKKLQRYLTWQQHDSRIFNVGNRRRKTAGRRVSVHPKLAPEHYSLDPPVQAAEILLNGAPAPREEPTELDLNRTESQQEADQSAQFFDPKNEKAAALREQVAMETLDELLDYLLNQGGAVGILDATNSTIKRRQHIVDHIKQREPKLGILFIESICRDPDLLEANMRLKLSGPDYRDKDPVKSLEDFKARVEAYASAYEPLGDYEEEHDMQYIQMIDVGRKLIQHRLKGFLSGGLSTYLSSFNLAPRQIWITRHGQSVDNELGKLGGDSPLTERGHCYAQSLHRFITHKRKEWIMEQKSKLAQASFPPLPGDNTPPYPDMYSDLDEKNFCVWTSMLRRSVETAEYFDVDDDYDVKNWEMLNELNSGQFEGMTYEEIAAKFPEEFRKRANDKLNYIYPGVGGEGYLQVISRLRDMVREIERITDHVLIIGHRSVCRVLMAYFMDLTREDITDMDVPLGMLYSIEPKPYGIAFHAYRYNEASGWFDELPNYKPQKAARGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVH4</accession>
    <name>A0A2T4BVH4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1425197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVH4"/>
    <dbReference type="STRING" id="983965.A0A2T4BVH4"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="201" mass="21965" checksum="46B9CB549BDAB802" modified="2018-07-18" version="1">MTFLILVIGDLHIPDRALDIPAKFKKLLAPGKIGQTLCLGNLTDKHTYEYLRSLSPDLKIVKGRTDVEATSLPLTQVVTHGGIRIGFLEGFTLVSNEPDLLLAEANRLDVDVLCWGGTHRFDAFEYMDKFFVNPGSATGAFLPGASLEAESPTPSFCLMDVQGISLTLYVYQLRTDEKGNENVAVEKVTYTKPVEPSTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVJ7</accession>
    <name>A0A2T4BVJ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1464823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVJ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BVJ7"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="59"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="293" mass="33090" checksum="8B9020710413CCF2" modified="2018-07-18" version="1">MASPSIPCPPRGIYVPAVAFFHPDETLDLDAIRAHLTRLAEGGVDGLVIQGSNGEAMHMLHDERQQEEAGEAWPKIKGFRYLLQDKPHGTMLEDKFIEGLKYLGKRGFSFEVGIDQHRRGRKQLEETVEMIGRAHEGVPDEDKVTFIINHLCKPDLTIYNVSSDPSFTAWRTAIFSLGKCSRTYMKLSGAFAEMTPALRAQKSPSHIFQSLLPWLGVVLATFGPRRLMFASDWPVCTVGLEQEKTKDGEEENEEDEAWPKWREVVEKMCWMATLSDDDRAMIFGGTAKEAYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVM6</accession>
    <name>A0A2T4BVM6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1061177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVM6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="8390" checksum="CD2655E5E3D28A1A" modified="2018-07-18" version="1">MWRAPQGGGRGQRCCFSGPAGFLGLVAPGLQSVCYLLPAGVFVCVCFLSDDFLGNVGDGVESSVLVFWGLRITASSVPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWP3</accession>
    <name>A0A2T4BWP3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1339347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWP3"/>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16541" checksum="695CA41061A77D3F" modified="2018-07-18" version="1">MIILLAAVFFCYTLIRLWLIIHRGDPPDVPRAVDPRGYAVPRNPIRVVMAQDEEAVGVESETMAMKPPAYGLWRESVRVDPNRFFWQRNDAAEPAPPQTATGPRPPSYASDDGVSYVVDAVPRSVAPSSEGEQQPVHPSERGRAGQPPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWR0</accession>
    <name>A0A2T4BWR0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore complex Sim4 subunit Fta1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1381556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWR0"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="45942" checksum="B0A20B575C2CFFCD" modified="2018-07-18" version="1">MARQTAQTSAQRQQKASGRESAHQRHQDGETEEIAIPQFFNTTFSTHRVSPLYAGTQKLDQARLDRLAHRLRDTLVGDVVRGVQIGLEATDTPMGQVGPLKAVTFRWFRATDVLGDKTSEGGDELADEQNKGLWIELRHENAAYVALLLPGLSQSKKVSNRPTASQFLHLPLLLLRMPQPLKAVIGEWLSATFDCRVTKLNLGTRTLVNVLEGWLQGTGLPRADSDLVLTLAFNAPVTDKGREAVLPSSGDVGDNDDDEENEATEPGLRSMEISVSASDLRRFLRAGKALQKSKRAASNTASTVSSNKASWEHDDIERRRLAGPHIDDGWGWLKGKDAPPYPLMEALAHHLDHHMALNLFHPGVRVTQISCGGFVLSQSRIKIVKTGDVTEDLSKAAWMFVTLLGERLQNNRMSLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWX9</accession>
    <name>A0A2T4BWX9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWX9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="89" mass="10237" checksum="23B6A570C1958B64" modified="2018-07-18" version="1">MDWEDLGMEGNIGHGYGKGFGLDDLQLPTTAVYLSFVCLLSFLNSFHSFHLFGVMYGMSVYRDLYQPCERNEHIMFQPLRLTEVKHIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX90</accession>
    <name>A0A2T4BX90_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1432797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX90"/>
    <dbReference type="STRING" id="983965.A0A2T4BX90"/>
    <dbReference type="OrthoDB" id="4895966at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015469353" evidence="2">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="131" mass="14453" checksum="486FE54D883B78CC" modified="2018-07-18" version="1">MKSSALLSCIAFAASVAAAPVPDSDTVASYQWKKNIENTDGVASYQWKKDTANTDGVASYQWKKEKRDTAGTDAVASYQWKKDTESTDGVASYQWKKEKRDTAGTDAVASYQWKKDTASTDGVASYQWKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXF2</accession>
    <name>A0A2T4BXF2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1404225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXF2"/>
    <dbReference type="STRING" id="983965.A0A2T4BXF2"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015530804" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="20124" checksum="7FC7D0F0FE82D47F" modified="2018-07-18" version="1">MKAALLLSALASCAIGLVAAAEDLKIEVTHPVECDRKSQKGDKLSMHYRGTLAKTGEKFDASYDRNQPFNFKLGAGQVIKGWDQGLLDMCIGEKRTLTIPPELGYGQRNMGPIPAGSTLVFETELLAIEGVKAPEKKPVPETPIVEKPAEETEESVVEKAAEAAASVASEAVDAAKTVFADTDEGHGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXN3</accession>
    <name>A0A2T4BXN3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1404188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXN3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXN3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="98"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="357" mass="39007" checksum="AEEFC68049201028" modified="2018-07-18" version="1">MDALPLTVEQALATGIMDPEFEAAWKAIGSPPGSIPSDIPTFQKTVEATLPMAQKMLAASRPQTIVERECEIPVDDTFSSRTIVCHAATPSTTPSPIVILVHGGGHCVGYPEMELTTARELVLAHNATCILPSYRLAPEYPFPTDVHDIFAVVQYIARKATEKNRGDILPASADPKTGFVIGGLSAGAAISNNVAQLARDLPLEPPLTGLFLACGVFFEPGCVPDRYKEFYLSLEHNKSAPVFDTPSLIDYSNAYKGDRQSSLKNPSSVDHQPRSDASVADHRFLPPAYFQVAGLDPARDDSLIYERMLREERGVPTRMDVYRGLPHGFWTQYPDIAASRKRMRDAVDGVGWLLGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXT0</accession>
    <name>A0A2T4BXT0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1040024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXT0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="145" mass="15505" checksum="8DEE5875E9E79038" modified="2018-07-18" version="1">MIWDDDSAFGSKATRGRAVKMTTSTELDGTCEVSVASRTRGGIARSSDGQGHSRAAGADQGGPPAPGWLRRGRRRGQLSRGLPKSADIAAGRPQRRDGAQVAVHRCLLSVRHSCQGVRSGTNPSTRTSIICKFRENPSHIRQWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYM7</accession>
    <name>A0A2T4BYM7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1360248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYM7"/>
    <dbReference type="STRING" id="983965.A0A2T4BYM7"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="222"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="38"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33821" checksum="80FB4672F1A789BA" modified="2018-07-18" version="1">MASSILRGRALGAVRQSRCFSSTPRQCAADVKSLGVLGAGQMGLGIALVAAQKAQVPVTLVDSSEQALNKGIAFAEKLLAKDVSKSKITQQQADQARSLLKPTTKIEDFSSVDFIIEAVPEIPQLKFDIFSKLAKIAPPHAILATNTSSISITRIAAATTTDPNDTSASSRVVSTHFMNPVPVQKGVEIISGLQTSKETLDTAVEFCKKMGKITSVSADSPGFLANRILMPYINEAIICLETGVGDRDSIDAIMKNGTNVPMGPLQLADFIGLDTCLAIMKVLHTETGDSKYRPSVLLGKMVDAGWLGKKSGKGFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYY8</accession>
    <name>A0A2T4BYY8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1403044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYY8"/>
    <dbReference type="STRING" id="983965.A0A2T4BYY8"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="279"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="548" mass="61695" checksum="3EFA382EEBA24ACE" modified="2018-07-18" version="1">MASITRSNRRAEGLHLYDRNVNASPLTRPAPGPNSFHHGAAAGGRTKRALDVAERDLDALRHKKTRIAVEILAKPQLPCEPVNVQPPIPRRAAVASSAPRPPVAPVPPTRPAASTATTSTPAPISAAAPDPEPPNASLTKHQAKVINGIRHELDRLQPRPDDTKDTKEQGRKLRSQEATRFKSELSAYFPDYDEVIGNDPKEQHLLNPDTPIIIIDTSSSRAIPDAQRTGPRPHHQQTLSGADFPIRGYGDALFTDVFDAQRIDFGFLDAQHKNKNIEDPLPDSLFEPIHKKAERVERSIRNTEKGRAQHEKDQIIRLLEGLQGHDWLRVMGVSGVTESKKKKFEPARMHFIKGCQAILAKFRNWNLEEKRRKLEKEKALAEKAEQEDGSDSSDAESQEREDSRSGESDESEDEEGEAEDEVEEDEPSQDDASETSSPAKQLRREARARSKLAAANSKRSRPAHKPAPPTKPPEPPREFKSFFAKRYERESALNRQRRAGRKILAWGHPIPDIAEADFILPEEYRDEETLKARERKKRRDRRELRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ38</accession>
    <name>A0A2T4BZ38_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1463927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ38"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ38"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="508" mass="56807" checksum="748D05D7FB5295FC" modified="2018-07-18" version="1">MVVDTAYYDTLGVSPQATELEIKKAYRKLAIVHHPDKNPNDPTAHEKFQAIGEAYQVLSDADLRKAYDKYGKDHAKPQEGFVDPAEFFSAIFGGEAFVDWIGEISLMKDLAATMDIAMDEGEEGEAAPQGEEEFPGTAEAMKESMKEKEKENQETFAGSASAPPPAVVVEEDEKSKTPVQPTTATPPPRSEATSPAPSYGSRSRQIPIRPALTEKAHDDADKEVDHTEDDVKGKGKKKGGMSKEQREKLLAYEKERARIRQERVEALTRKLLDRVSVWTETDKGPDVTRSFQEKMRLEVENLKMESFGIDILHAIGQTYMSKASALLNSQKFLGIGGFFSKLKDKGTLVKDTWNTISSAIDAQQTVEDMAKMEERGGEDWTDEKRVEYERRVTGKILTAAWRGSKFEIQGVLREVCDGVLKDKKVPLSKRLERAQALMLIGEIFIKAERSPEEEGDYLLFEQLVAEAAMKKDKHEDHKHKKDKKSRDMTAEEVAQDAPNVPKPEQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZA5</accession>
    <name>A0A2T4BZA5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1337035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZA5"/>
    <dbReference type="STRING" id="983965.A0A2T4BZA5"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="135"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="38005" checksum="4AB3FE9BFF173517" modified="2018-07-18" version="1" fragment="single">MSQRHHRYHAREPGVARAPGPAPAPERSRAVEELHPVLLDLILRMSIVPPEDIGSLSEAALGNAISLAISMLPDDEQTHIVSRIMTDDEIARERLDHPRLQNLQSRVMLSQNERRLLLRASPEPDEDDANQDEGGANGCIICFDRNAVAVPCGCRYCASCLRELVRVGLRSETDFPPRCCRPFIEATIRLAGRPALVHLFRQLSAEYAVPPAQRLYCHNASCASFIPPSAIQAAARDEANATAVGTCPSCSSATCRECGGRAHRGLPCSAEGDDEALFDMMDANGLVGCPRCGVVISLMDGCNHMTCVCGAEFCFLCGEDWNFECNCPLYNARERRVPVRQRPGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZM7</accession>
    <name>A0A2T4BZM7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1337232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZM7"/>
    <dbReference type="STRING" id="983965.A0A2T4BZM7"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="308" mass="33499" checksum="9A8B927449B24239" modified="2018-07-18" version="1">MASLFGSAASSASASTTVGDLKQDVALSDPPTDSISDLAFSPAPNTPDFLAISSWDNKVRIYEIAQNGQSQGRHAYEHSQPVLGVDFSKDGTKVASAGADKNVKVCDLASQQDIVIGTHDMPVRSVRFFDSGSGTMVVSGSWDKTFYKTLQSPLKWQTRVVSCFPDSTGFAIGSIEGRCAIQYVEEKDASSNFSFKCHRDPVVNNVVNVHAVNDISFHPVHGTFSTAGSDGTFHFWDKDAKHRLKGYPNVGGSITATTFNKTGSIFAYAISYDWSKGFQHNTQNYPIKVMLHPVNNDECKPRPSAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZV2</accession>
    <name>A0A2T4BZV2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1471405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZV2"/>
    <dbReference type="OrthoDB" id="3946700at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015418234" evidence="2">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="479" mass="53305" checksum="D635D7199472EDE2" modified="2018-07-18" version="1">MPRLSLLLAKSTPLAFSLFVAPVETDLPHKEATKRDVLSPGRSAIRRSAHAGFRDRRNAIRRAAVRIVDIPPPSAPQSPQRRVGTTSWETEVGYAEEPEPSSGPGREALRDVTTRPERRRDRYLEQQMSSIFGGTWHSFSPSSQRDDEARAERDLRWNEDPRPHLLNEEPRPRRARVVAPDDLRRHRHPHEHRSHQLGTPPLRPARDGLERSRTESPSNDDISQPNAFQVYRRWRRNQAQAREFRALMRHSYANTRPDTNSFDGLGDRDRSLSPEGWDTLLSTLTPDPQPPSATSSFASAAASQSAGSSNVPPPAPGVHDEAADGACESGHEMSDDDDDDNNNNNDDDYANWESRAAALTRDVGVVRFYSLNGVPAPGVPFPRPESLRRIGSLAPRNPSLSLTHGRTPGSGSEDESRPGRLQPNREGSAGNGRGAHTGDEEWSGMQRIVRSLAAREDIPDEWWAEAGLNRTLPQDGSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZV7</accession>
    <name>A0A2T4BZV7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZV7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="83" mass="8823" checksum="7F493CBD296F3351" modified="2018-07-18" version="1">MAVARTGMGRGRTPRFQPGTEWEPRVSVDQKSLLAAHARGFVETATEKTSPSAAPNQGLPVSQPQSGPLRYPAGSSTQAVYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZY5</accession>
    <name>A0A2T4BZY5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_67070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZY5"/>
    <dbReference type="STRING" id="983965.A0A2T4BZY5"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="128"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="317"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="759" mass="85869" checksum="9E49DD9DDE750099" modified="2018-07-18" version="1">MPEDYITEKGKLDQKKKEEALYKRHVERDEYGQEKFVTEHDEWEREQTTKAKAQIQGRERENEDYDYVLDDAQYIQWSLDSRMPGERKTLTKEQQFLEAQIEAAEKKALSIQETRKSLPIYQYREQFLQALEQYQILVIVGETGSGKTTQLPQYLHEAGYTKNGMKVGCTQPRRVAAMSVAARVADEVGVKLGHEVGYSIRFEDCSSEKTILKYMTDGMLLREFMTEPDLAGYSAIMIDEAHERTVHTDILLALVKDLARERKDLKLLISSATMNAEKFAQYFDDAPIFNIPGRRYPVDIYYTPAPEANYLAAAITTVFQIHTTQGKGDILIFLTGQDEIEAAEMEIAETAKKLGNRIKELVICPIYANLPSELQAKIFEPTPEGARKVVLATNIAETSLTIDGIVYVIDPGYVKENVYNPATGMSNLVVVPCSRASANQRSGRAGRVGPGKCFRLYTKFAYMNEMEESPLPEIQRTNLNGVVLQLKSLGINELLDFEFMDPPPTETLIGALNQLFALQALNHKGELTKIGRQMAEFPTDPMLAKAVLAADKEGCVEEVLSIVSMLGEASALFFRPKDKKIHADSARNRFTVKEGGDHITLLNIWNQWVDSGFSPIWAKENFLQQRSLTRARDVRDQLAKLCERVEVAPSTCGANNLRPIKRAITAGFFPNAARLQKSGDSYRTFKNNTTVWIHPSSVLMSVDPPEKTVIYYELVQTTKEYMRSVMPIEAAWLAELAPHFHKKKDIEALEDRKMPKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C031</accession>
    <name>A0A2T4C031_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_67093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C031"/>
    <dbReference type="STRING" id="983965.A0A2T4C031"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="237" mass="25368" checksum="FCFBC441BD86A255" modified="2018-07-18" version="1">MKHLSHLSSDSPAQDVSAARSDGKLHLLLAASGSVATIKIPNIIQGLSRHPNLSIRLVLTSSAAHFLQGQAAEQPSLEDIRKYPNVDAIYTDESEWVQPWTRGAPILHIELRKCKSVIAPLSANTLAKMVHGMTDSLLSSIILAWDTDGGVDGKKKKILVATAMNTAMFRNPITQRNLQLLNEVMGGAGGWVEELQTISKGLACGDVGKGAMATWQTIVAAIEEKLGLAADESKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C054</accession>
    <name>A0A2T4C054_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1359579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C054"/>
    <dbReference type="STRING" id="983965.A0A2T4C054"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="567" mass="62690" checksum="6DFE5D5A1982373E" modified="2018-07-18" version="1">MAQHITMPTREFKQRRSHEKSRKGCTRCKIQRKKCDEARPICTRCKKRNHCCQYTFEDDCFRSESTETSTGRTALTLETPRLEYLSLPGTSPRSSAASSDEICLSDSGFFPASPYPASGVSQTLPQPFALSSEELELLSHYITHTSRSIPFDTDELYALHVGIPNLAFGSRPVMGSMLALSAVCKCYDIVRHSHAPLERLEEIKGLFVLADQHHRTSLHQIQAAIYDDHFDTLLANAPLMVLYALAGHCVRVLLAQMARKGGRALSNEMFPLQSQWITSIRAAYVAYVGVHNSPSPSSDFEDGIPTSPCTVKDDCPSHFAALSGGNLYPPEDGPSEGTRRLLLPIVSATYGAAMEKLTARAQTVWLEESNSKTPARDSCNPELQACLTSLKLLDELFTTIFANTPSSHELSPSASSLSGLQLNGLDKASPWLKRYLARVTSATPSKLWRRTIMAFLNRVPLDYLQLVQSALDQMPVATNQADSGCFDKAIPLGAAQQLALNIFSHWLVLVMLLDGVWWIGSIGQWELGRILSFTEAQCWTLEPTETGGSWWPESMYAVQKAIADPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0G3</accession>
    <name>A0A2T4C0G3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 24 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1402637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0G3"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107:SF3">
        <property type="entry name" value="LYSOZYME RRRD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015569664" evidence="7">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="269" mass="28630" checksum="00B689D920D513C8" modified="2018-07-18" version="1">MKTAFAALIVSLTSLVSAYPITGDVVNCRTGPGTSYAIKTSYKKSHDISISCQTTGTSVNGNNIWDKTADGCYVADYYVKTGSSGFVTKKCSASSGGGGSSSGSYCKTINSAGVDLIAKWEGFVASPKPDPIGLPTVGYGHLCQQKNCAEVKYKFPLTKTTAKELLLDDLPKYTKCLAESLNTKPKLNANQWAALSSWVFNVGCGNAKTSTLVKRLNNGESANTVAAEELPKWRMAGGKVMPGLEARRKDEVKLFKTASSKEAYPKCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0I1</accession>
    <name>A0A2T4C0I1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1335701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0I1"/>
    <dbReference type="STRING" id="983965.A0A2T4C0I1"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23800" checksum="F3C3B6CD370677C8" modified="2018-07-18" version="1">MNRLFGSKPSGPKPTLTGAITNIDTRIASIDTKLKALNGELSAYQEKLSKMRDGPGKQAIKQKALKVLQRRKAYEAEKDKLEAQVWNMEQAQTMQDNLKNVMTQVDAMKTTNKELRKQYGKIDIDKIERLQDEMADLLDVGNEIQESLARGYDIPDEVDEAELDAELEALGMEAELEQEYGSGAVPGFLQDEVVPEFVDEPPQTEEKVKQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0S6</accession>
    <name>A0A2T4C0S6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1439739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0S6"/>
    <dbReference type="STRING" id="983965.A0A2T4C0S6"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="295" mass="33053" checksum="FE903B4B1445BB2F" modified="2018-07-18" version="1">MSRDKKFALVTGCGKGGIGEALVQEYTRRGIFAVATVLPNENSDHLTAAGITWFPLDVTDDESVVSLKKEISSLTNGYLEFLVNNANTMLTVCRDVAGYTMTAIDTDIEAVRRMFEVNVFGPMRMVHHFHGMLIQAAGTIVNIGSIGGVVPYMYGASYNASKAALHHYSNTLRLEMSPFNVKVLTVISGEVGTNILKNDVHRKLPEGSYYEPLADDFRNHVQRTPKTTSRFEYASNVVSQSLRSSPAPWFWTGSATGIIRFLDMFAWRTIWDFFFYREFNLNKVREAHLAKKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Z6</accession>
    <name>A0A2T4C0Z6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1431776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Z6"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Z6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="559"/>
            <end position="560"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="578" mass="61313" checksum="D1B13FC38F3907C7" modified="2018-07-18" version="1">MASYDFIIVGGGTAGLVLAARLTEDSSKKVLVLEAGEDLTGDARVSVPAMWPTLLNTDADWKFKTIPQPGLNNRAISFPQGKVLGGSSAINGLSFTHSSKANVDAWFKLGNPGWDWASFSESLAKAYTLTSPSADVTGSGPLQLSYPKDTDNVWPSIWQQTLEGLGFPKSEDTTKQSCGPIFVPDTIHPASKTRSYAGNAYLEPARSRENLTVIPKAAVSRILFDRTGNAVTATGIEYIKDNKTQTAAGKEIILTAGTINSPRLLELSGIGDAKRLEKLGIEVIVNNPNVGENLQNHPMCGLSFEAQDDEKTMDGLARQDPAALQAAMAAYAQQLGPFASSGTNNAAQLPFPGIKTAEGKAEVEQLISKYITSAKKGDNAAFVEAQADFVRSILTSPDEASGYYISFPGYAAFNPDGTMAPPPPGTGKHFSIALLLTHPLSRGSVHITSATDVAIDPRYFSHPLDIEVLARHLGFVESIASAQPLASHLKAVEKRNAAADQAKEYLRQTAVGAHHFTGTCSMMPEALGGVVDAQLRVYGVSNLRIADASIIPLTPRANPQATVYGVAEHAAAIIKGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C130</accession>
    <name>A0A2T4C130_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1423342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C130"/>
    <dbReference type="STRING" id="983965.A0A2T4C130"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055497">
        <property type="entry name" value="DUF7069"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23239">
        <property type="entry name" value="DUF7069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="199"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7069" evidence="4">
        <location>
            <begin position="391"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="500"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="596"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="645" mass="72469" checksum="52D5F6A9E39F2D59" modified="2018-07-18" version="1">MSDPHKYTVGWICAITFEYVAAQAFLEEKHEKPEYVSPQDNNNYTLGRIGRHNVVIAALPYGEYGLASAASVARDMLHSFPNVRIGLMVGIGGGEPSAKHDIRLGDVVVGISDTGQGAVVQYDFGKAMQGQGFRETGLQKLAEERRDIAREQLQAQKDFLKERLSKEEQRCHQLFRLTVSGKDATYEWYKDRIENRVEDTCLWFLKHEHFQAWLKQESGPLLVTADPGCGKSVLAKYLIDDGLPRSATICYFFFKDQDQNTSRQALCAVLHQLFSQKPFLIKHAMLQFRTDGQGLINSTESLWKILRDAIRDPEAGSIIIVFDALDECAELEFASLIRNIESHLHNDQSGNGKLRYLLTCRPYEQITSQFHGLLEAFPNVRIPGEEESEAISQEVNHVITHRVNQLSAKKRLSFEYTTYLETSLQKISHRTYLWLYLIFDYLEKEDFRKTLDGIDHAIHALPKSINEAYERILIASYLGHRAVAQLMVDEGADLEAREAYGQTALFRAAEEGHGTIVKLLVDEGASLDAKNYDDQSPLTLAAEEGHEAIVKLLVDKGADLEVRDAFGKTPLSRASARGHEATVKLLLDKGASLEVKNQYPLLLAAEEGHRAIVKLLVDKGADLDVRDAFGYRWPDSAINSSSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1V7</accession>
    <name>A0A2T4C1V7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_323854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1V7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8479" checksum="CE4F9C82733723C4" modified="2018-07-18" version="1">MLRLSRYLFFPWRLVIRPNFAPTTATPAILILTVSLSDCSSISSHNAGPTDRWAGFLERLWLLRKAAGNAMRSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1Z4</accession>
    <name>A0A2T4C1Z4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1392130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1Z4"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="471" mass="51391" checksum="678D57A93776A083" modified="2018-07-18" version="1">MSATETTTEVEFLQQRYSPRIAGRDDAAERGRSDIELSQLYSQPHNNNNLESINRAEPITQELKPVDRGRDAWCTLLGAFAFDALFWGFPGCYGVFQRYYSSVPAFQPDSPRIPVVGVLSTGFYYFGSPFSAMLATKFPRYQRHQIYLGWVLSITGLLSASFTSSVNGLIATQGALYGLGFVLISMPIVSMVNEWWVARKGMAFGLISASSGATGAVLPFIIDALLRRYGYKITLRACAVAMAVLTAPLLPLFKARLPASDQANLARINWDFLKKPLFWIYGAAVLIQGIGFFFPVVFLPSYASLFDISSTKGALLVSLMSIAQVLGQFAFGYLSDKSLPVSLLITTCCAFAATASFTFWGLAKSLPLLAIFSCIYGFFAFGFGTMRVAMGRAVSDDPSTVFATYAIFVFLMGVGNILVGPLSAELMAPREAIREQYAGNKYEPMVIVTGVTSFLAALIVLAWHGGKALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C220</accession>
    <name>A0A2T4C220_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1470587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C220"/>
    <dbReference type="STRING" id="983965.A0A2T4C220"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF21">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="37867" checksum="30AEA1BFBB491D74" modified="2018-07-18" version="1">MVKPRGDGESLLYASSILIGLSWITFAARIAVRFWRKSAGWDDILMFAGILLFTVTASLCIVCCYLGSGQLSEVLEPAEIMQGTKLFFIAEYFYSSGTVFIKSSIAVTLLRIADARRRYKWTIWAVIISTIISCIVFISGISNICHPITTLWGETTTGSCNLQLNSDVSFFFSAIEILTDWTLAVLPAALLWGVQMKPKVKFSVAVILGMGAFASCATIVRLRFLTLYDNPAEFLFGTGKIGLWSIIEEGIGIIAGSLHALRPLLSLPFFGGGSSGGNTDNSGHNKYSPRSGHRGPAQHTDIGLDTFHQLGDGEADGDGDSSKHILRETKVTMYGRSQVLGWKREQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C244</accession>
    <name>A0A2T4C244_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1439309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C244"/>
    <dbReference type="OrthoDB" id="4899554at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="297" mass="34316" checksum="3FC860768CC51DBC" modified="2018-07-18" version="1">MEADSEIYSYSEGEALPPQMVDPNWNVLDHLSPFHKACYMHHQRHRLTHLKALGVYHADDQHILLLDEAGFLSAVGVALPTREQLQRQPHEFFYGKEAEQEMLKEALSCVAAQVLDILEKADHTHAAWKSLRQLLKTDPFHHKTPNALLKAVKEAGMEEEVIWMFLPEFGPNETAAGAVIIPFKMVLRGICMVVGYASHEITHPFEQLMEIDEELCENVYEFRDMYQRMTAHVVEKGSNETEIINLKIERLRKAWEKVFAFISKGYMKPKMDGILRSWGHVLFEEESSYSTDSEHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2A2</accession>
    <name>A0A2T4C2A2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1422811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2A2"/>
    <dbReference type="STRING" id="983965.A0A2T4C2A2"/>
    <dbReference type="OrthoDB" id="5106279at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015426440" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="351" mass="35513" checksum="A8BC6E52227790A1" modified="2018-07-18" version="1">MKVILALAIVGVTGVFCQSTHSTADFSYQGCSSIDPACFGEAIAIANGPMTPEACQSACRGHLFAAVLPDCCRCGDDPNGVHSTDEFKCDYPCLGDSTRGMCGSICPRNSPVIANVYIRVTPSQGQTYEDPTNVESSAAAAVTPCSSDGASDSSPSSQRVTPVGPAPEAPTSFGNPATGGPTATELQTNEDPITQASKGTPCRTQGDTGGSMPSQGPQGPQGPLTPPDNAPEPKTFSAPNQQSPHTTPSSNAPSYSSNCQASQPGSYSDENGPGTPGGSPGGDTSGDNCDPPADPSLSPDVSQTTLWPWPSKKPEGDPPAPSHVPASDSPCGVVPPLSSIGGFILLAAMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2W4</accession>
    <name>A0A2T4C2W4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_42439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2W4"/>
    <dbReference type="STRING" id="983965.A0A2T4C2W4"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="127" mass="14586" checksum="EDF4E51B3C93BEBE" modified="2018-07-18" version="1" fragment="single">LSKEAERCLQDLRLTDPRDDKSRIEDTNGGLLQGAYDWAIKHNNFIAWRDAGENHLLWIRGDPGKGKTMLFCGIIDELQDRGVKPCYFFCQATDPRLNSATAVLRGLIYLLMVTNRQLLSLIQERYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C392</accession>
    <name>A0A2T4C392_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1438814</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C392"/>
    <dbReference type="STRING" id="983965.A0A2T4C392"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="15">
        <location>
            <begin position="77"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB76039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="533" mass="59314" checksum="B0727581E3317B26" modified="2018-07-18" version="1">MEPVVYDETPLADYLRDNARFLEQFRYTIIASQLLSGHSLPGYRPPALKSPGSTSDNNDQTLLSTEGIIVSVVGALALAVFLSWALSSAPSHVTKRRLILVLIIAAAAVLVGQVFVRRQWLRYRREQALAEISTFITNSQNFDSATEATLSLVQEVELVSRGYRISVPLAPVSRLEDRTQSRKCIRLRKALKNAFADVLQTYNQVSDVVRGFAEQMELEKYYDMYDVSDFDISDSRLGFNAAEFDDLESLRTLKILAARFHTTRKMLLCALLALDANGEVKDLLRWTAAVESLQSVNTLTKSVFEKLQGILSEEESFPLPPTPQLPLTPGKERWRSQLRKLNSMSTGIRGLQAKLHLLREESDRALDDSNDISEMGPNLMSQYDSIGVDLRMLMAAWEEGRAALAQGIDRNEKRLSSISTLLSPASSLSGLTTIGEGGTADAFKALTGESPPASEIHDGEDDQEVFEAVAKPRPRSMLTREERIAKVKEEREQRASARQQMEATKGMLRELETVISLRPQKRASAPVGPRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3L7</accession>
    <name>A0A2T4C3L7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGS207 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3L7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3L7"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46789" checksum="739504372AE26608" modified="2018-07-18" version="1">MSGIISYIPGASLLLGGGRAKAIDLPPVEIHHIETIADRRARCLKHLLKANHANYAILFNNLRFDNHNVHILSSAYLLGANENQLHDIYNDEIQDLVPWEPSPSELIDEDWRDFLGDKRYQRAFLDYFEDKLAMEFAYDWKQELQHFLFSGEEPLFHGLIGGLGHPLIHLGYAYEVDSREVAMEALALTCVQYNFFHKYLDNRSYTRPSPLKSKAPLDLLSQLSKDDRFSKAPEDLGDLEEFLDKNESLFLEYWNGWDVDDDPKKQFELSQEAAVALLVGTVAPGTHAYDFFIVHLLTTSHAVRILLPFVPPKHHVTLVREWWLLVLATFLVRGRPMPDPDNVESDLKGKNWKYVVDKALNSAWSKDAHFVKAIRAMKEAAQTWGDVHERYLRAAVTFVDNFHGWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Q0</accession>
    <name>A0A2T4C3Q0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1401645</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Q0"/>
    <dbReference type="STRING" id="983965.A0A2T4C3Q0"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015599135" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="95"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB76190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="195" mass="18874" checksum="1E36DC484397C3FB" modified="2018-07-18" version="1">MKASVLSLIFLSGLAAAQIPDCATSCVTKYTTGTSIAGCGQLDIACICKNDDFLNGIACCLASACDKDGQAQAVKYAKQICSSAGVSTPDNVVCNENSSSSATESATATDDSSSTATTGSSESTTAESSSETTATDNSSSAAATTNSASRTTASSVTSASQTASSASQTSTNVAAPLASAGSLVGAAIAVLAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3T1</accession>
    <name>A0A2T4C3T1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1333471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3T1"/>
    <dbReference type="STRING" id="983965.A0A2T4C3T1"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22448">
        <property type="entry name" value="KH-I_ScSCP160_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22449">
        <property type="entry name" value="KH-I_ScSCP160_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="200"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="282"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="379"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="698"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="765"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="858"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="931"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1271" mass="138342" checksum="E25B028E0A924F64" modified="2018-07-18" version="1">MASEGSAPAVVANGGEESVAQRLQQHHVTVEDAPDDELSSQAADDASSTIAPGPSAAKTPAKRQQAALDTQSRELFPELGAPRGKSPSVVPIWGARSDANGGSNGGSSSSAPASGSATPAPQVPHRNMDLPGPKPQTITLNPTFLRPNVKVEDVLPGFNRKSRALVSMSKLPDGSRVFTARGPEKLAQQALKDLVAQIGAKLAVQVPIPQSTRPFIIGKGGATIKAIQEKTGAKIQMPKVDENQPVDSQDDEAIVLVTVEGNALSAAAAQREIENIVNERSANVQTKVSGVPVAFYPFIAGPGHSLAHEIEQANGVQLRVPTNQLYSSAPLPVAPAAGGRPVFAPAAPDDEHIQLAGDRRAVQRARELILRRVAELQRELEYEQLSIQRGRHQFIIGQRGIPLEDFFRETGCAILFPQEEDDDMVTVVGPPSQVQAGLERAMDLAMGMQMSNIDISRSHRNAPGGALAHAANVTRYLRQRKEIERLEKQYNTHINTPISQDGALPWELYSREGKNAIRAQSEITAILNGHPPSRMQTVAVDPFFHQHLRNEITPKVKKEFGVQMVVPEASEANAPVLLVFEGPDPAEGAYQPPRVKPSDAELQTFRQALEAAQKHILGLINKQEAIVAVSLDVPTKFHEKLRRFIKKEQENRDESQIPVRVTKVGNTVTLRGPKSAVESLASKANAFIEQEKIDEKERGYTLTFDFPQKFANHLIGKGGSNIKELRDRFDVEIQVQDGKVELKGPQAKAEKARTYIQNLGRTLADETTHVLKIDPKYHRELIGAQGSQINRLQTRYNVLIFFPKSAKNGDDQASEAASDAGKPRRQQAPDEVIIRGPKKGADEARDELYSLHKYLEEHSHTATVGVQQKQVGSLIGQGGAALDELRQQTGARIDVPADRDTPIVEITIKGTAAQVKKAKQILEEKRAEFDDTIVQTIEVDKKHHKALIGAGGSTLRDIVTAAGGSSDRRALARTIQFPKQESDGNTIKIEGRTEVVNNIIKKIQEIVDERESQVTEVVDVPIDQHRSLIGRGGDAKRQLESQFGVSIDIPRQGDGKTGVKVTGRAENVAKAKEHISGLIKQQHSETVQIPRALHHIVSNGGQIFRQLRNNYQVTVDHDGQSVPAKPTPSARAVEGALPLITDDADAAADVHSWKVVSLESSDEGEIPWVLRGTPENVAKAKELILKNLAQAKVNDATGYLILPDPRTYRFVIGPNGSKVKSIRNQSNCQIQVPRDQAKDEAIEILGTREGVEKAKDLILAAVREGLSKSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C423</accession>
    <name>A0A2T4C423_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1391808</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C423"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="556"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1149"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1185"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="383"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1025"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1274"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1348"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1276"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1384"/>
            <end position="1393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PTB76268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1393" mass="151891" checksum="C6A4983A20D7706F" modified="2018-07-18" version="1">MADSEQTKPSGPPTSRRRAPTITIDTTAVHPNSSVTEVTQDVNGQQQPAYTSISPSSHPDDATSPSTMVEPPYGFFQGGRPDLRTDTSFDTSRDGSRPTSPHNISTPIAALGNEHGFLVVPPNNLRSRQNSVDSEDASRSFVSGGDATVVPSSSTQTDKYKTTPANDKIMSDETALKPDAGTEADFEVQNNPFAFTPGQLNKMFNPKNLAAFYQLGGLRGLERGLRTDRKAGLSTDENLLEGRVTFGEATSKKGDKHNGDAAPPPANAARVSTQSSHKPQGFQDRYRVFRDNRLPEKKGKTLLELMWITYNDKVLILLSIAAAVSLAVGLYQTFGQQHSADEPKVEWVEGVAIIVAIAIVVIVGSLNDYQKERQFAKLNKKKQDRNVKVIRSGQTMEISVYDLMVGDVIHLEPGDLVPVDGVLIEGFDVKCDESQTTGESDIIRKRNADEVYEAIEHHESLKKMDPFIQSGARIMEGVGTYMATSTGIYSSYGKTLMALNEDPEMTPLQAKLNVIATYIAKLGGAAGLLLFIVLFIEFLVRLPHDHGTPAEKGQDFLNIFIVVVTIIVVAVPEGLPLAVTLALAFATTRMLRDANLVRHLKACEVMGNATTICSDKTGTLTQNKMQVVAGTVGINNEFSNSRVQESEDDGTVSAPEFVTKLSAPVKDLLLDSIALNSTAFEGDVEGEKTFIGSKTETALLLFARDHLGMGPVSQLRENATTLQLIPFDSGRKCMGIVVRLADGTARLYVKGASEILLAQCEQTLHDPLSGAAVVSMSQEDTDAISELIVKYAKRSLRTIGLCYRDFESWPPRGLRSGENKGEILFEDLFQKMTFAGMVGIQDPLREGVAEAVKLCQSAGVVVRMVTGDNKITAEAIAKECGIVQADSVVMEGPEFRNLGKLKQKEIIPRLHVLARSSPEDKRILVKRLKEMGETVAVTGDGTNDAPALKMADVGFSMGIAGTEVAKEASAIILMDDNFASIVKALKWGRAVNDAVKRFLQFQLTVNITAVILTFVTAVSSAKESSVLTAVQLLWVNLIMDTLAALALATDPPQDSVLDRKPEPKGSSIISPTMWKMIIGQALYQLAITFLLYYGGTKVVGPIVGDDNLKHEDIETLVFNTFVWMQIFNQWNNRRLDNKFNIFEGLTRNWFFIAISTLMMGGQILIVFVGGAAFQIAKKDQSGGMWGIALVLGIISIPVGMLIRLIPDAFVVKLVPEFLKRRAKQVPGLTVSDEEMDMYPEPLADVRDELNFLRRMKGGRLNNLKFAIQHPKEMIARSRSQSHSRSNSFNASSETQGREDSFPSRVATPISQQRSRSTRSTRSRSNSALGAPTVMAGIVAAGVAAGWSPIGRPSAEDREAMMQLYQQQLQQPRIESDSEQGQKPAEGHTSEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4A8</accession>
    <name>A0A2T4C4A8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1333029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4A8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4A8"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="260"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="588"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="690"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="96380" checksum="E30CE430A9DE4EEC" modified="2018-07-18" version="1">MLICVHQLHNVDVKLVGKMQVMYSRLNNSEAVYERFSIKSEDAHVVLRFHDGDEQFGYLRTAVAATLSPLLAKPHLEFEPVALTSELLRIIGHASKPADAIVKVDINVYGPSSAGTEVGDALSDGKLWLQKPGHVRAGLAYDNPHFLRIETNGARPQPAEPVRQLTSNGATSRRNREERLRKMVEEVYSSLNRNRQYDAADAGDRVSQKLLRHQEEALGFMLERESGHINERYCLWESVKLEDGREGFRHRITRAKIRNGIRPNERGGGILADEMGMGKSLSILALVMRMLDDGRAWAQEQENNPRVEGAIKRSRSTLVIVPSALLVNNWLKEIRLHLRDGVTKIRYHGIDRPRELDTIADSDIVVTTYSTLTSEFQTKSTPSLLHSIDWYRIVLDEAHIIRRRATAFYRACDELHANSRWCLTGTPIQNKLADIGTLFAFIRAEPFCKASAFRKWIELPFDQRGDDLNLVKERLIMLIEAFCLRRTRDIIDLPELQQRVRVLTFSAEERKQYVDTEQILLRKHRHRVGEYKESTKFGQFQVNLQMRLLCNHGTYQQPFSWHRRSYTYRDECEAIDSATIGQSSEITCVGCRLPMPVLGSSRMGNGFYEQCAHVVCSECIEQSHTRSEVGEAQHCPVCIRWLRHAMVESGGTANDDSLQKDATKKKKKDDDAYYFSNEGHSTKMEAIIQDVKVDLDKTKSIIFSCWTRTLQLLSKYLNQHHISYVLIDGSCSLTERQTRLDLFADDKETPVLIMTTGTGGFGLNLTCANRIFIVELQWNPGVESQAIARAIRLGQKNKVEVTRYMIDDTVEREMRSQQQWKKQLASLGFDEMTNESDAEMFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4D1</accession>
    <name>A0A2T4C4D1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4D1"/>
    <dbReference type="STRING" id="983965.A0A2T4C4D1"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="266" mass="28642" checksum="D778730B7AD34728" modified="2018-07-18" version="1">MASPHHVLILGGHGKVAQFLTPLLLKRSWAVTSVIRKQEQVPDVEKLGAGLPGRLSVLVRSIADVDSQDKAARILDEVNPDYVAWSAGAGGKYGTEGTFRIDRDAAIHFINAAASRPSITRFLLVSYSGSRRKAAPWWSAAEWQDYHNSINLGPLATYYQAKLAADEVLYEVAKQSPTLVGIDLRPGMLTDEPRGKVTLGKTKNVKGSVPRETVAHVADALLAAEGVKSGWLDLLQGDDDINAAVDAVVREGVDAAEGEDIHARYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C509</accession>
    <name>A0A2T4C509_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial export protein Som1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1332699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C509"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14697" checksum="F7192B3DF29E82E5" modified="2018-07-18" version="1">MTPPCRSFPASELPLRIQQDASGRRRKLDDAGSVSRRIDLSACELFQMLQYKCEVQRPLTRESPVRCFAVDRLFRRCKDKKGVFTVETTAWEGERARVDSSSSEITGTKEPPKPHQWSSSWHDADEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C527</accession>
    <name>A0A2T4C527_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1332379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C527"/>
    <dbReference type="STRING" id="983965.A0A2T4C527"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="570"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="633" mass="70666" checksum="3B8025CF2171A5B9" modified="2018-07-18" version="1">MSSKRAPLASNPNVANSPLRAPSLLAGFVKPKRPFATVQREEPYGQPPPVKKQALENGAQKPVRSPSKLTRPPAHIVIPRNPSAVPRPTVRDRTAKAATTSTARGGQDVDTEKEVWKKHHRAKFPKMVFYFESIPDDIRAKLTKRVTYLGARQEPFFSIDVTHVVTTRAIPPEKPEAGAAEAEVSEEQEPREQPQTINPSLLDRNTAARRRLLFDFRQASSAPSQVNDPAKRKAARNNDVLHKARDMGKKIWSLDKFQSMLAVLLESETQSYGSRSVSSRSHYGTKSTHEPNLFQLLHNERINGPSDRDPTATTRELTYFKGPYLYIWDMDERQKPIMVREYAKVANKTDGEWPQFRSVGNGRCPFVEEVDAAEKEYRKAREREKARLAAAKEESVQILKAPEVPPMKPVTGKRTLTEMEEAHSRVRAGVAAEETFQPIKATFAKPPAPPAQNAFISRAEGGRTFGGEPVASGIQNTITSAIRSQMISSTSGINGAKAGTSKEVHGLQRKVLQMTHPASHDASRRLAEAPAEVASSRSLSRTTSKTIQGQEDDGQKAEKKAPTQHLKSKRDLKPGYCENCQDKFRDFDEHILSRKHRKFAENDDNWIELDALLAQLKRIPKYSAASDESDGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C556</accession>
    <name>A0A2T4C556_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C556"/>
    <dbReference type="STRING" id="983965.A0A2T4C556"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="33290" checksum="085EC679567C98D1" modified="2018-07-18" version="1">MASNLKIALIQLYSKPLDIAGNFARAESYIRKAASQGAQLAVLPEYHLSSWKPDGKVLLAAAKESAPYLARYQALAAELNIAIAPGTILEPIPAAEAETDDVAAVTKTEGIANAAYFIGPDGALLGRYQKKNLWHPERPHLTADGLTPHRAFDTPWGRMGLIICWDLAFPEACRALVADGARFVICPTFWLNSDGGDIGAEVNPECERLFLENVAIARAFENTCGFVFCNTGAPLGSGTSGKDEEGTEFIGLTQVAMPLQGALGKLGVEEAMSVVDVDGKVLDIAEEVYKVRADIAMEGWHYAHTLCKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5G3</accession>
    <name>A0A2T4C5G3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1421886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5G3"/>
    <dbReference type="STRING" id="983965.A0A2T4C5G3"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55089" checksum="13AF93182B3F3CF8" modified="2018-07-18" version="1">MSGEPPSSPRLPAFTRKRSLVSPQSLRFNSSDPAVFSSDDDPGLDNYVEGRRKKRYVGSWFQQRLDAAESSVDNGAGRVSTVPPKRLLKRDLDSGIFLGSDTTDGEDFIEHLEAPAVPRLPQIAPRTVPRLSQPEIVARQKIQECIDRGNEMVDLWGVGLEELSDDIVNRLGQVTSIPVVAKDVAFVPPPPNLQVFLALNKLARLPGSLCDITNLTVLSLRSNGLTELPPAISKLTNLTGLNLSHNKLRYLPSEILELVKPGGKLRDLSITFNPLWRPQRPDSCTADDACEERGRRKHTSSWLSMHRDKRGYMVHWLGRSPLQVSNSNGRVLSEFRLPPMDEAPEPSEARVSVAVYIDEESGVPVSLSSQASAGLRKGEATPGSVPSLTELALRSCYRSSYLRDLDSLIPEGLSHLRKLVQRTSLQKDMGGLPCSTCGKTVVVPLLEWVEWRELLKCSSKDSEELPRARIFTVEELAVPFLYRACSWRCGPTDEKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5I3</accession>
    <name>A0A2T4C5I3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1332620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5I3"/>
    <dbReference type="STRING" id="983965.A0A2T4C5I3"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63508" checksum="4A0EBA883009D9CE" modified="2018-07-18" version="1">MEEKEAGERRPCLDADYYDLGDLHRPVSTSNALAQTWFNRGLVWCYGFNHEEAAKCFERAVAHDPTCAMAYWGLAYALGPNYNKPWDLFGRRERQTTADRTHRAVEKAKACSEAATPVERALVEALRHRYPRADAPTKADRPIWNREYADAMSSVSAQFPDDLDVAALYADAMMNLTPWALWDIKTGAPAADARTLEIRQVLEHAMSLPGGTRHPGLLHLYIHLMEMSNTPEAAMPAADHLRGLVPDAGHLNHMPSHLDILVGDYARAVVANSDAVRADEKFLRREGPMNFYTLYRSHDYHFRLYSAMFAGQSRVALETVERLEASFSEDLLRVETPPMADWLEAFLAMRVHVLIRFGRWKDILALKLPDDQDLYCVTTALTHYARGMALAALGQVADARAQRALFLASVPRVKPSRTLFNNKCIDILCVAEAMLDGEIEYRSGNYPSAFAHLRESIARYDNLPFDEPWGWMQPARHAYGALLLEQGHVEEALAVYSADLGKDESLPRVHRHPNNVWALHGYHECLVKLGRAEEAKAVQGALKRALEVADVPISSSCFCRLTAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5U5</accession>
    <name>A0A2T4C5U5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1469983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5U5"/>
    <dbReference type="STRING" id="983965.A0A2T4C5U5"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35677" checksum="9572D34DE81BF600" modified="2018-07-18" version="1">MGNDVLLEKGVSTPDADTVGGAGVGQILDDCKRNPLYQLKTLFLFTKSDFKTVIVPQSIFAATAALSKTQLTTATPEGSDVTNGWGIVSRIPLMLAWIWLNLLVEDIANQRLEGAIVEDAVNKPWRPLPSRRLTPEQARDWLIISIIAAVGLSALFGGYSASITLMVFIWMYNDLEGSSSGIWIRNALNAGGLMCFSWGALATLSGGELLPRGFAWILVTGAIIMTTVHAQDLPDIEGDMARRRLTVPLTYGETAARASLAVMVMFWSVACPLVWDASLWGWAASTGIGCAMSVLALQKRGQRWDEVVWKLWCLWITVLYMLPALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Z1</accession>
    <name>A0A2T4C5Z1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF323 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1401324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Z1"/>
    <dbReference type="SMR" id="A0A2T4C5Z1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Z1"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="9">
        <location>
            <begin position="276"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="469"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84479" checksum="9E1D3C6B4D2D0E7E" modified="2018-07-18" version="1">MASQIPEGAIVVELGSGNLRKVCLLLQAFEDAKKKIDYFALDLSQKELERTLAEAPAFEYVSCRGLRGTYDDGCEWLKQEAILARPKCILHLGSSIGNFTRDEAAEFLRSFAEVLQPSDLMIVGVDSCQNPDKVYHAYNDSKGVTHQFVLNGLTHANEVLGQEVFNVEEWQVVGEYVYDVDGGRHQAFVSPLEVASVLGHIIKPHERIKIEQSFKYSDVGLDKLFKTAGLVEVAKWDHQGEYGLHMLKRAKMPFPRLRELYASGTLPTWADWENLWAAWDTVTRRMLPDAELNEKPIKLRNACIFYLGHIPAFLDIQLKKTTGAGGTEPLYFHAIFERGIDPDVDNPEKCHDHSEVPDEWPPLEDILTYQDRVRERLRKLYASPEQLVGDVRRAVWIGFEHEALHLETLLYMLLQSDKTLPPPHTVVPDFPKMAQKAYAARVPNQWFDVPEQTITIGMDDPEDEHDLNRHFGWDNEKPARQETVRAFQAKARPITNEEYAKYIYTSHIENLPASWSVIPPNYHHNTNATTPGKPILSELPESFLHDKAVRTVYGLVPLRYALDWPVFASYDELAGCAAWMGGRIPTMEEAKSIYAYVERQKDIAKQSKLSNKVPAVNGHLVNDGVEETPPSRPSPASLFVDLSTTNTGFLHWHPVPVTPRGGSLAGQAELGGVWEWTSSVLRPHEGFRPMSLYPGYTADFFDGKHNVVLGGSWATHPRIAGRKSFVNWYQRNYLYAWVGARLVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C617</accession>
    <name>A0A2T4C617_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C617"/>
    <dbReference type="STRING" id="983965.A0A2T4C617"/>
    <dbReference type="OrthoDB" id="4107844at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17191" checksum="BD265DFFCB8C6E9C" modified="2018-07-18" version="1">MWSRKTSISISTSPQEDPEVMRKSMNTHIERVFGETDEAARGKTMESLYHEDVTWLQPAEYSGDQAIIRGRDYVNTTIQKEQSQFPGFYITHDKEGYTAVTQNLGIVHWQLGPREEPDMIKACHYLLFEGGKVKAFWTAHLKMPNGPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C695</accession>
    <name>A0A2T4C695_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C695"/>
    <dbReference type="STRING" id="983965.A0A2T4C695"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="13015" checksum="537C800C9422DBA7" modified="2018-07-18" version="1">MPPMPAVNPDYSEDLASRTRRSMAGFEKAQQKAQMERRRNLRRAKAPPRKEGSYFPRVDEDLSETTQLLEQLAEESDVEAVFRSRPKIAQSLQPSPTRNEWADVPAYHGVRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6A5</accession>
    <name>A0A2T4C6A5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Infection structure specific protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6A5"/>
    <dbReference type="STRING" id="983965.A0A2T4C6A5"/>
    <dbReference type="OrthoDB" id="3561078at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015653586" description="Infection structure specific protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="20167" checksum="22064B18AC483E4C" modified="2018-07-18" version="1">MSSNRALLLLTLAASASAAIDYMAIPQVRDLLPAPTPISRINNLARDASNDAECASSALDLLQSIPTPPPALLSDLSKSVESQQTDPCKMSFPASLSADVSSYSSEVLSWYSGHEAELTSLAKECTAAQSYTGLVNVCTKDGSSGSGSSGASETTASAPSSGTAGAATKTAGASTATSTNAGAARETGMAFAALAAAGIAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C743</accession>
    <name>A0A2T4C743_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1329888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C743"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="127" mass="14916" checksum="5AD2766CA2DD0339" modified="2018-07-18" version="1" fragment="single">VPLSRRFILQKTGELLSLRAKLNHYSELTDNLPDIFWDSRSELGLEGYYDQVGRALDVNVRIRALNQKMDYAQEIATVLRELSSEQHGTRLEWIIIVLIFVEVVFELRRIVIEYRERAVLRELGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7W9</accession>
    <name>A0A2T4C7W9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1400561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7W9"/>
    <dbReference type="STRING" id="983965.A0A2T4C7W9"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="59273" checksum="D76EC8F0A4750441" modified="2018-07-18" version="1">MMEEPQRCKVAVIGLGAMGIVAVKNLLEEGFDVVGFERSSYTGGLWHFTEDEDTLSIIESTAVNVSIDRASYTDFPFPVGTPTFCTAKHVEDYLEAYVDHFHLKPHFRLCTTVKSISRDQDDGRWKLDIKGQPSEWFDKVVMATGPHIKPMMPELEGADLFTGRFIHSKGFKKPEAFAGQRVVIVGLGNTGSDIADALVGHASHISISHHHGAVIMTRLLDGVPATSRISYRFIQFQGIINRWIPKLAEIVYNKAARQIMRDAFGEVDPAWGLDPALSVLVANPVVSDTLIANFRSGAISSITGIRRITGGRRIELASGETIEADAVICCTGYKNDFSLLEKQYDPSSTPSASWLEAPGSKNRPYPRLYQNVFSMNAPDSLAFLGCVWFVTGAFCLADIASMCIAQVWSGKASLPPQPQMQRWVDKQEKRICALAQRGAVIPATVPPSEWLSWADETAGMGVGKHVGWGWKAWVFWWRERTLWRMVMDGPFTSVFWRLFPGRRKCWDGARAEIMRVNREVEERRAKAKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C815</accession>
    <name>A0A2T4C815_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1221604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C815"/>
    <dbReference type="STRING" id="983965.A0A2T4C815"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="344"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="671" mass="76576" checksum="58FD0A17519537B6" modified="2018-07-18" version="1">MKMLSPGFPMRRSSGLVRYGVLAAILLLALYTFTRSSSEISRLPQPFPADNSLPDQKPKPIPNANSDPPVVGGAKAPVATAPLPHGTSTPAQEPAHDSIPPLKPPTSSDHPIDKLVYDAQMTFAELTSKQSNTVEEAAQAYRKRRGRHPPPGFDKWFEFARSKNAIIVEDFFDRIYQDLQPFWGVDPAVIRKESWDYEMTINIRDGNATARSDFFWTKIWLKMIKTIDHLLPDMDIALNAMDEPRLVVPWEEMAEYMKNASKTVKIPKAKDTIREFQKLPRPGTGDVEIKTRAKNWEKTKPYWAIARRGCAPDSLARSVGLVQTANRTPDINLTFAEPHMYKGYVSNFSLSTEICHQPDLQALEGIFIEPLSTSASKVLFPMFGGSKLGVNNEILLPAPMYWNEEERFTGGDNHGIPWTEKHNKAIWRGVATGGQNTASNWRGFQRHRFVAMSNGTTVARVEKGEKPENFALPPSEEYNIQAQKDGKLGEWINTWANISFTDLSCTPPQNGKCNYTGHYFKPTKGMKMAEQFDNKFIPDIDGNSFSGRYLGFLRSTSLPIKATIWHEWHDSRLVAWKHFVPMDSRFLDYYGIMEYFLGYEGRNGHDRVAEKIATEGKEWAEKVLRKEDMQIYVLRLLFEYARLLDDKRESLGWVDDVLKDPSLEKTWKWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8F1</accession>
    <name>A0A2T4C8F1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1469688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8F1"/>
    <dbReference type="STRING" id="983965.A0A2T4C8F1"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="251"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46244" checksum="898D0B8A68A3F772" modified="2018-07-18" version="1">MFQQKKPYSAVTVTIETLTSEAYDEDDLSGIPDLVEVITIQASGPTEAARAIRKKLKYGNVHRQLRALVLLDGLIQNAGPRFTRTFADEPLLERLRVCGTSDLSDPEVRKKCRELFSSWSQYANKPGLERIARLHKELPKRKVTVTQERSRVIKETENPFGDEEDDEPASPKSPSPPAAAGPSSHGRSSHSRGSSMVDSFKHQQTSSLSLSNSGSGGGGGGSSVFGGSSSSDKKKRSSKAKSKRKPFNLEAEKEQMKSVIAESSLAATNLLNVLQTINREKERISDNSLAVERFESCKILRRKVLRFIHHVDHEQWLGPLLHANDELVHALMTFEQLDQSVDADSDSDDELAEQAHLYRTSPDPQGACLSAICQTKSADLQPTIHAPRFPFRPFTWADGVASTAMPHRDPAKPRRVPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Q2</accession>
    <name>A0A2T4C8Q2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Golgi-associated retrograde protein complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1421640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Q2"/>
    <dbReference type="STRING" id="983965.A0A2T4C8Q2"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="613"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="825" mass="92269" checksum="B22A5EE782C80B68" modified="2018-07-18" version="1">MNGSLAGSSASSLDAIDYDPIAHLNLLFSHPSAVSSISRVSQALKHRQDDLEYEINTLEMAQAYEPDSSLERMRSAQTELAQLFRKIETVRSRAIETEQNITSMTADIKRLDGTKKNLTLSMTALKRLQMLTTAYEQLRGLAKTRQYRECAGLLQAVLQLMRHFNSYRSIEQIATLSREVSELQRELLEQVCEDFEMAFTKGEVGAKKGTLVEACLVMDALGDSAKARLVGWYINTELREYRQVFRGNDEAGNLDNIGRRYAWFKRMMKTHEDEHAAIFPPHWRVNETLATAFCDGTRDDFKGILERSMRRPDGNKIDVNLLLACLQETLNFEQSLDKHFSSDARASIDTLSSTEEKSHTFNGLISVAFEPYLSLWVESQDRQLAAMIPKYRTQPLIPPEEEFAPQAVISSALELFHFYKLTLSQCAKLSTADRLLDLSKILAKYLDEYAQQVLLRKLQSSGQKNPSMQDAVLVLNTADFWHINTNQLEENIKKRIDPELVARVDLSSQSDAFLGVASAAVLALVRIVEVDCEGVWREMRNTNWSTMESAGDQSSWVGELVKHVNERAKEILGIVAKQQYARAFCDNLVDHLATAFINNIVQCRPISEVGAQQMLVDKYALTKSFENLMSYHNPSPAQQAPSATFVRRVEQSMNRMDPLLKTLQVRPSPPEGLVQAYLIHIADRSDTNFKKILDLKGVRKMDQAHLIELFGIHRDGSSNEKLAQNSPLLTPLMLSSSLSSTGAMGAINTASSSLAGGSAARFDAGSLGEKLLSAARDISNTGQSGSDKATINENLRNFGKFFKRDISGLGLKFGMRDGAEDGHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C904</accession>
    <name>A0A2T4C904_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_17672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C904"/>
    <dbReference type="OrthoDB" id="3590765at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="319" mass="33769" checksum="7B952503A9D6262C" modified="2018-07-18" version="1">MVSAIATPPIGGSPYRLANLANLQIGYSVVPSWLNQGAAVPMANVSPPSSSSHKQGGARSSVSVTLTEALQTPPGVYTVQQLVANSGPLLDVVISRLGQDPPGQPSASSILIDGLAASLSTRGRESTFPLENASNDAARSEIVHQANRVASTIVKHVKKTVKPAPKSLDFRIRSPCEGHLWTHSVAALLFGPRSDSQLMELYNEWLHRMVLLRDSLIPFENFEEVPLASDSTAYVHSAASILSKPGLVISPRVTPGSPPAVHVIPTADPILRLALLGKLYPENVVLVKEHDSLGALGRVGKNFAEKIVIFEKNAAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9F0</accession>
    <name>A0A2T4C9F0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1187047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9F0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="161" mass="18331" checksum="78D87B5907280DBF" modified="2018-07-18" version="1">MKSFILHNLIENIIVISTAKEAKFLQCTLPAHPTPTPTPTAHQKPPHQPTPRGKPLLSFAIPQPIRPFPLPTTFLHLPPVLEEWHMDLPVFILRSTLPLTERKRKAARIVPKVGRGFQTYIEKVDWNRVTLGPRPSSPPRENTLLHSVGVKKITPYSRWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9N3</accession>
    <name>A0A2T4C9N3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1399449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9N3"/>
    <dbReference type="STRING" id="983965.A0A2T4C9N3"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="830"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="860"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1195" mass="135999" checksum="0F1B975F3D6E9E56" modified="2018-07-18" version="1">MPLSRRTSLEAQRVMREAFMDLERVITVADRAQLKDLTLDDVRQAALQIEQQLAASQSLRNMRRLAPLFTGLGHYSQAIEVLCNGTPYLPWLWAPIKLVLKISADYIEAFEQIIKIYSRLSEPLTRFSFVQQPFSNNLEVQNALAVYYSDILRFHAEAYNFVRRNAWQRLFATSWGRFQRRFDNIFADLKAHEKLIDKLVNAANICEAKDMREKLEDWRQQEMCKLKKQEEDRTSTEFHAILSVLRVDETHQIKVFDSLTAEANQNPGSCGWILQQPKIQAWARSDHNTQSVVLHGCVGSGKSVLAAQIGTFLRSSEQSLVAAHFCTYLYPESTDYNHMMRSLMVQIIRQDPELIALSYNRLVIQKKAPTCAVIEQLLRLLVEALATSPSQQKTLHIIFDGLDECDDSTVSSIVKTLDKLVATASTFGATILKVLLCTQMTPAVAKVVKRKRQVSLSDEIAHLNRAIQDYTLRRINAIRPNLSQLRITEDDIQSLASRITEKADGMFLWAKLVMEFISKNFFYNREEILEAASKLPRELGKFYGRMLAQIMANFDERSVQRISSVLGWISFAKRPLRSPELLSALAFDAGHAQANEPVPAYILDRCEPLIQKQADSSYAFLHVSVRDFLQSSDSALSITIHHSQRQHGLATVHCLLSCQQIFAPSYSEAQRVGRILRGTHGFHIYATQFWVDYLLESLDLDQSRFFDSEIFVLSCRLAEAFTSSRPSSEGLDGDELDPRLGLIRQRHYSLYLMAKGVILEQNKGSLEDVSNNEADDIQNDINHHAVACDLIALKEKYQVMIRGLLEYSTYPGVTFQELEQFRQYFRTSAFTCRLWSCPYAVIGFSTMNCLTQHEKEHAKHVCRFAGCQYPVFTSARMLKMHVAKYHANNERREARHTIRGHSKRRTSPSQQESRSAHTNEDVSNLSARNRSFDSPSSGPLAAENQLLSNGFVPSEYPSEASPWIPVKPMDGIPLPSSPASRTYLSSNTIKQPAGEHSIDTITPDQQLGHFSAPGAPRLQSALLSMPSDKEEAFPAPRPVPRNFGLAEESFQPTNATLARIRIEANATPSDQAATRLSLLPKNLPRVEPRYFDVHPPSPLQWCNDLLIRFKREYPDSEIRCVTEDAASGSGNINWQPRFYCADCAYSLDFCGFTFRNFRNFRKQFEEHLNSRSHRETVRRRAPPQRSYVHSLLNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9W8</accession>
    <name>A0A2T4C9W8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1399501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9W8"/>
    <dbReference type="STRING" id="983965.A0A2T4C9W8"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19383" checksum="40EA63FC9458043A" modified="2018-07-18" version="1">MTTHGMTSGQIFRSLLTCTLFYAQSATRYIGLITSSLQLFTFKQQEEEDSSTLAMSAPNPLPKYIYKILPSPPQDPLPKEFPLSQLDANDGFVHLSTATQVPNTADLFFTDATQLWLIKLELAKLADPVKWESGFPHLYGNFGAADVQGLEKFERKEGRKWSEVMKTSTWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9X4</accession>
    <name>A0A2T4C9X4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1190291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9X4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="17812" checksum="E8AAA3B3C34CEDE1" modified="2018-07-18" version="1">MHGLSTSKKGTCYYYYNCTTYTKDRQTTAITLRRTYTYIQGATPDYEGSYSRGDPRAWKADKQETSKPSPVILQCADNTIQLLEPLPPSFSVETTSNTTHPLAAHRIRWHSLLLQGSPPFKFPAQQIHHEALLGFLAASCRRLDERVTDMRETRGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBG4</accession>
    <name>A0A2T4CBG4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1469179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CBG4"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1527"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2075"/>
            <end position="2147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2147" mass="236950" checksum="25E04B0B8B3E6B9A" modified="2018-07-18" version="1">MWHMLRERLRTVCDLIEKWAQKQPDHIAVSFGDRKITYAELENATTYIAWTLCERQVKPGDKIPVLAQRSLEMVICFLGVIKAGALYVPIDVESWSRDRIRWTLERVSPRIILNTGMEKFPGYGEISLQEIRRAFEPTMERRWANELDRPWKRIKPSDIMFIIFTSGTTSTPKGVMIPHSSVFNYVQQGGEKTPFNMNSTPADVVMLIFSPAFDACTAVIVSALSNGAEVKIATPADFLHTATLCTVMACTPSVLATIQDPSNYANLRAIMIGGEAAPASLVRKWGEHLPNTPMYNVYGPTETTFACLVARLYPDKPITLGYPMSNCCVRLLDGDVESRYGEICVSGPGLARGYYENEALTAEKFVYWEGERMYRTGDFARLTEYGLEFAGRKDSVVKNRGFLVNLDGQVIPMLNSSPDVISATAFMHRGRLVAFVTPETVDGIALRKSLITKYDSFIIPDVIRSTESLPLNANDKIDNRALQALLDIEDSQVLSGGLVPKISSHGSKMDVLKAAISFAVSLPPTNIPDSSSFTELGGNSLAGIKVVSFLRTTGYQLRLGPLFDLPHLSAIQDVMEPLDDAEEEEVSLEQGSAPSIAPMTSLQTKMIRTGLRNPATSYMLMRFMLPHQNKVFNGNILQSAWRRVIERHSIFRTVFNLKDQLQQVQPTLDLEWVNEETTKDQVETLLRVRSQEMRKKINYVEHEDTFTPISAYHMVTVPGVASTFLALVHHSLIDGWSFSVMLEELCLALDGKQLPEPPQFTNIALAQARLQQDAQGNEFWDRLLRDGLSQPLLGLPKPSQDTVVADWSSSLHINLGYGPKELEAKARLRGVTPATAIYAAWALVLSNYSFSDTVAFGAVFSGRNIEVLGADRVVGPLLNTCPFPLEFKGRQSVADALSMVQSQLLRMLEFQWCADNAMAKLPAEDIANAFQTLVVIEYGLPPLPQSCETLPEPWTIERQDMMEFGITLLIEESSEANLRARILYDNSQYTEWSIAGLLTHFDHALSGLLDPQNTLLHHVRDAIVIGEERAKLLESPKETIRSRGKSKTVKDAFETAAAKWPDLAALESTKESMSYRQLDAAANKLANHLRPVTSPGDVVGIFTDGSLHWIVAILAVLKAGCICCPIDVSLPTARIEVITQQSGATFFIAANRDCLRVAQNIQDSRVIVSEEFQASRKTPAPSLETLSRPADVVYLVFTSGSTGIPKGVALHNQSLLGVINHEPNRLFSRPGRRLGQVYAVGFDVALVEIFGTLLYGGTLVLKDPSDPLSHLKRVDAIYSTPSLLVALSPNAYSNLDTIGLAGEAVSQSLADAWSHKRLFNFYGPSECGPISTGTELLPGHQVTIGKPIPNLELYLLDHHHCPVPIGVTGEIFISGDQITQGYWNSPSETRMAFLPNPFSPGKIMYKTGDLGYWTRDMDVVFVGRIDSQVKIRGFRVELEEVERAITAADRRIKTAAAIADRNHIVAFVTPSTVNLEAVRQKVKELLPAYACPARFVALDTLPKSSNLKIDRTALRALAAGAEEEGNDPSTPTEKTIAGIWSQVLSSHTNTHKRRITRDADFLAIGGNSLLAIKAARLISESTGYHVPVPLLIREAVLSNLAQAVDQCGARDESKDGTPSFESFLSDLPGPTSLTTAQTPSPLEEELFLWQTISDTKSLFNTAFQFVIEGHISIDMLRDAFIAVMQEEPILRARYVLEGGLLYRSISDEIVPPQVFVGKALDATRLQALVDKPFDLARDQLLRAIFWKQDDGSQTMKTSLTLITHHIITDKASLAILLQSVSKKYRLAVEPVTTNGQNGAAITPKGTYIEWTQWQAKMTSLPATPATLAKQRFWHGRVGEMEAVPLLDKNGLGSFGRDVPCYESLLIATGSSFSFSQRMALAAAAITLFAVVGEQEFVFGIPYMNRDEPGTANIMGLLLDRLPVRIKLNNSNMSASARLINDIASEVTDCVQNQLPYMQILQMCKRRRPLFDVVVIYHWKSDALEHSLQLPEAQISSRRIRARGAKFTLQLEFTEQGGGLHCGIEYNARALSAPQMAAIMSFIPNVINGLMVGSAPANILSSLNHLKDCNPLALMPAYKDRVEKVREAFSEALGLHPEIGLDRTLYDLGGTSVTALRVQYLLNKKGMIGSLGDILTAPSAVNIAWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBP1</accession>
    <name>A0A2T4CBP1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1389056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBP1"/>
    <dbReference type="STRING" id="983965.A0A2T4CBP1"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="630"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="733" mass="82138" checksum="B8B33C1A3DFD8F1F" modified="2018-07-18" version="1">MRTRRSNRAKRYTLDQYDFLESGDEEQPQKQKSRKTADDNDDNFETAAEERSAGEDEEEEENEDEDEQMNESGSDANPADGPSRQRSSKKTKQSKLGAKQSQPVDVGVLEVNGYLDIELVPPDGQHKGYVGPYDRGMRNKSLARTWFGPNPDRISMAIELLERWAGWTLLPPKVPQDENEPTDKGFWIPGGLDKEARLAEKWHVQMSAALPSDNVWLELSLEESQPFRFPQLSMPMLTGPSEAQLELSMEPGRCYSMSQSNIPYDQDQDEDKVQSGWVLDVGGIVLNMDWAPRRDKNPKQLLALAIIPHSDQEMYNYEEESVKPGFQKQGVVQIWEFQGVTTDDAFIRPSSQPAILRKTLCVDCGRIRRVRWSPSRNHMAFLCGDGSVYIADAGDLDGQEEGVYYQLHRPLAVLSLADEYAIKATAMTWINCNRIAVGYSDGSIALWSIYPQCLLSRHPVHHNDIIDMASGYPTMPTVIVSLPVGGTARILDLQAPSYEVTEAQRPLVHTQPGLLSYSDHLQGFVSIYPSASALNTVIGFLHHAHFPVCRRIFTGDSFLTCLSVGRLHPFLLVGTMDGSLWCFNAQTEVFSNRHEMTDKIRIFRHEHRPGYLFPPESPAAARGVSRVTHGYGVDKNRNSKLEGKQAAKKGKKLRAKEPAEVPEGEREGEGEEDDEEAGDTDPSRARLHEALTRITAIEWNPNTDYGCWAAVAMGSGLVRVIDLGLEKYPESTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC04</accession>
    <name>A0A2T4CC04_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_64246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC04"/>
    <dbReference type="STRING" id="983965.A0A2T4CC04"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="818" mass="89086" checksum="5BEB43B699684CA9" modified="2018-07-18" version="1">MSQQSQPGRTASFNRGYSGTVEGPQIYSASYSGVDVYEMEVNNIAVMRRRHDSWLNATQILKVAGVDKGKRTKILEKEIQIGEHEKVQGGYGKYQGTWIKFDRGVEVCRQYGVEELLRPLLTYDMGQDGGVAGRGDFNTPTKEQAMAAQRKRMYNAGADGRPNGLSGTFFKNISSTASHAVAAISKARFGSPGPRSRNGPTRAPSFSRQPSMQNGDDFPGNSQQSYTSDYTNPAVDSAYSTQQQQQPQPPQQHQQSSQHQQPQLNGSVSMPDNEPPRKRARVTMTPADSFGPYSQNIDPYAANFPGSPTEPNESFVYTQNTLNEREAVDEGNGPSPPLPYELSPDVEMKRSMLMGLFMDSATEELSHDMLQTFTPLELDMPIDPQSHTALHWAATLARMPLLRALIAAGASPRRVNASGETALMRACLVTNSMDQGSFPDLLEVLGSTIEFRDHKGRTVLHHIAVTSAVKGRNAASRYYLESLLEWVVRQGSVPNSQATQLNGHGLNGSQSIPKMGIARFMSEIVNAQDSSGDTALNIAARIGNRSIISQLLEVGADPEIANRVGLRPLDFGIGGENAEGKPNGDAVVEKNGAPGSNQRSRESSDEIIESITHLLNETGATFQQEMKAKQASLDNLHATLRTTSTQLGEARRSVEQIAATLKKQQLARQKVANLTHAREDDQFRIMNEQSNAAQSNPSSSWETELAAMLEAADEASASGGGGGFASEGMLPSATILRARIRAIESRKEVTRKMVQALKGRSRDVEIKYRRVVALCTGVPETEVDAVVDGLLKAVESEKDELEIGRVRRFLGGVEGVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCA6</accession>
    <name>A0A2T4CCA6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1436548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCA6"/>
    <dbReference type="OrthoDB" id="4899484at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="226" mass="25520" checksum="5880CE91E8A7A8AB" modified="2018-07-18" version="1">MARLKIDELRITNPTMRTFDHEAVIKVDESLDDIDWTSHVTVSLYYRPHASGKASIKLERFDIRNMVGFKNFMQHLLPNEVDIEIETANGLTVTGRSVDEAHELSLNIELSGISKASVKDFYFRLVERTVIIEFNFSSPSPVVLDFGDCEFSLERGGEVLARLDGYFRIGLEDPEVLLQGDAIAADTRFSGFGTLRGVKALEESNTWVAHAIRSFEMSVDLDRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCF0</accession>
    <name>A0A2T4CCF0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1163461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCF0"/>
    <dbReference type="STRING" id="983965.A0A2T4CCF0"/>
    <dbReference type="OrthoDB" id="4959284at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="659" mass="73879" checksum="5280BA728E142E0C" modified="2018-07-18" version="1">MSSDSLKSRNTQQGFHKIFGNGRKRDSIHGDSNQRQAGDAPKAPSGSKRSRPVDRPDERSSAAQRDRGEKSAPTPTVSHRPRQPGNPNKPQSSDRLISVTANILKPVLDSICERMTWFQARHKHGKSLNLSRAIQEQNHYHPSDYPGSADLLVNQEQQLREDIESANQRIASTDEKIAAALQPLLQHLSNTCAKDCNSSGNSEERAVSEAKLAAVSITLKKETHDSIKQEAADIQQKIQELVESQMAKLKDAMIQDNEQKLEKKVDNKLHSLRLALTQEAESRATSLRKTLAHGYEQRLTEMKGTITQDNQKTIGELKMALAEANQKNAALHEQMASLEARLDQSASEQRQLLKSLVDEAQLSQKLQQLSVSKDEKLSKFEARLDSLPNHAPRLEQLEENMREHSKFIETKAQQQDAASTRLESMESTSSKALAEVREIKEHVQRLLSSGNSTTLLTNSQILDVVRPELAKSDEKHKLGMKRIQDGLAPFLGKERASREALESQLEIISAQISELQCECSTAQNRLSGFTENFEKQRQLFVGGLKSLEDMVNGRLNQAISELRSDARGLRPDFELSRDDFEGICLQLQALNNWQTHFSTNGLYRDIVAHIQNTLPESSRMRIDRLEARLAAFEMSLSNKRRKLPGNNAAMVDGHQPDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCF9</accession>
    <name>A0A2T4CCF9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCF9"/>
    <dbReference type="STRING" id="983965.A0A2T4CCF9"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="17621" checksum="DC65B067E889A530" modified="2018-07-18" version="1">MASQPFQHNAAPKRPRLSLKINTCSSSVPSRPVKGFHVDPTDRTACNTLSNVYATAIERSTPVQPEPLTAINTLQSFSLKTPAEPRGPKLKIKTPYVAAFPQTPTTDASGSSPPQKMDIAFPSTMTPTPPINGRAYSCNGYNKRKRDTPIPELAEAQDTLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCY6</accession>
    <name>A0A2T4CCY6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1468281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCY6"/>
    <dbReference type="OrthoDB" id="5372011at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="215" mass="25386" checksum="8956491059BB31B5" modified="2018-07-18" version="1">MSAQQTNFNLQYQQQLQQQHDQQALQQQHEHNPQDAQQAQQQRRKKKTQQPVKKKTFPTLMSPEMRDRQARGKNTHRRHEDDGTDEDEYDDEDDEDEDEQIEGHNARDDDDDEDEEDSEDGKTNSSSFSYRSEPFESRERRAYALAVLDRPEQLMMYANTTNDSVAGQRVRFTRMMCGFDDETDWRNNLHYKAALAAAKERQIKVRRGASIPRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCY8</accession>
    <name>A0A2T4CCY8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1419806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCY8"/>
    <dbReference type="STRING" id="983965.A0A2T4CCY8"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="12462" checksum="6777182FB9F89329" modified="2018-07-18" version="1">MSRHHPDLVMCRKQSGIAIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCVVCGGEGISDAFYCYECTRLEKDRDGCPKIINLGSSRTDLFYQKKTNRQANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDY7</accession>
    <name>A0A2T4CDY7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1429023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDY7"/>
    <dbReference type="STRING" id="983965.A0A2T4CDY7"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="364" mass="38454" checksum="DFA7B4599F511152" modified="2018-07-18" version="1">MVFPDKPVAHLLGSNGPVHAVTYSASPGNYILTGSADRSIRLYNPFPSTSVPEIRPSGSSAAKPATPQGRLIQTYAAHGYEVTCLAVASDNESFVSGGGDRAVFLWDVSRAVTTRRFGGSSAQGGHSARVNCVSFAGDGDALVASGGFDTTVRLWDVRNASGFRPVQVLDEARDSVTCLAVRGAEIIAGSVDGRVRSYDVRMGKCTTDVMGASVVSLDVTRDGKAMLVGSLDSKLRLMDRDNGTCLRAYSDPAWKSEELRVQSLLGGREKYVVAGDEMTGDVTMDGSGSGRIWAWDLLSGKVVAKVTVPWGPPGYEARKRTVGKDGKPKVRSNVISCMAWREGGWGDQFCVGGTSGVVTVFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEQ2</accession>
    <name>A0A2T4CEQ2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEQ2"/>
    <dbReference type="OrthoDB" id="10512106at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="451" mass="47813" checksum="97478D422B2E7AFB" modified="2018-07-18" version="1">MAAQEPALSQHTMVSQSIPFRTMGSSQGADSPQQLVFRPTAAGDSRSSARKRGRESTEVSQAQDPGPLYESKGSAIVGMTPSFGNKVAEFLFKNEPSTIAGSQVSGNLPMETADHYNSVLAYQAQNLGLSFPQAHSGPHNDIDPSIASPQVVPVSQEAQGMQQPGTHTGRTGPSQGIQSAGVSPRHGHFNVPAPQSGPQLHHSSGVPPPRSVNSGQTSGVGHPLDEGERRMAGAGFHGDHIQETSPMDWRAAKEDISGRQSAHEAQPFVASAPQNTASQSSSSAPANTQSVSQPSATNTKGRVPSPKTQRPISASVKAQTTPAKSSWMSTRVPAPRKAKVKSKPATRASGGVQKRKPDRVRQTTPPRPAALQPAAPKATVPQTAAFPNPIPSARREQQPATYVSGSGLGLTQDDVDRWQEERQNPYRLPSFNDAFGYTLMDVCLRLIVYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEQ5</accession>
    <name>A0A2T4CEQ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1108708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEQ5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="168" mass="18357" checksum="A1F80D7C4F49F14F" modified="2018-07-18" version="1">MAISRRAAAAVGSGYVMCDRGLTRLPQLNHAPYPTPSDRQVRQSSSKTRGRAGLTSSSSVLPNQSAAMLVSHVLILKTRTALALHHDGSAQGKPVSRGYVIFCRTQMSIRLRAREAAVWWARLGRFTPPRTPMPEDSCLPFFFPPLSSVASLPLSLVYIISTILNKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF39</accession>
    <name>A0A2T4CF39_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1435854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF39"/>
    <dbReference type="STRING" id="983965.A0A2T4CF39"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="281"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="768"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB80179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="941" mass="103065" checksum="D292D90D3C31B3FB" modified="2018-07-18" version="1">MAAWTTILVAYLIGGVTFIPLMVAFAFFYGYYNLPYRRALGFQDDNDDGGIVRPGDDTTALDEARRARNNSDSKRTNADVDVAAGYFAVCREYTPMGINAKPVERSTPIGSATVTPTSPSVYQTMYRSIFDRKAAASSVDGSSSVSQRPKKAGNVFYVVLRHGHLMLFDDEEQLEVRHVISLAHHRIGLYSGGDVTPEGELFIKRNAISLTRKLNESDHTPDNQASRPFYLFSENCSAKEDFYFAMLKNQQHTFGLEHIAPNPKQFELKSIISLVQKLHSSEDQVHSRWINAMIGRIFLGVYKTKDLETFIREKITKKISRVKRPSFLTNIKIQQIDTGDAAPYFANLKLKDLNVEGECVVEADLRYTGSFRIEVAATARIDLGARFKVREVNLILAVVLRRLEGHVLFKIKPPPSNRIWFSFQTMPKLELTIEPIVSSRQITYTVITRQIENRIKEVFAETLVQPFWDDVPFFNTEHKQLRGGIFEGDDAVRPSSQPAEPLAQIGDGEIPDLLDAGVAQTSTNAQPIDKSQQMPVIDTLEPAPSPLRKTSDKVASALPAFASSTSVELAPPAPVHSPRIVKPATEPIVGTETAHADLFKPSTSPPDYAMNHMAALRSRSQDASPIPIARKLSQSTLVSRRSSSSSKEMHGDAAGEDELHTDPKPESQPPQQHAASSPGLAVASDSDLSRASTAGSIKSQAGSLSRSLFQRRDSPGSGAAAALEGEGTVQKRNTLAAVTNVAAQARQWGWNAIQRQREAMRNNEKTIAVDLSQPMGRGQPLPPPGTPLPMPTNGGTRIGPVPTSKRRSPNLVLDEQVALVAEDGQGAAPSPGRQPSPPRRRRQDSRQQEDYSPNILVVAAPDDSQPTTPAIEDEARQTELWNGELPTTPQQGSDNPHAADDNSRCLEVGDTVTASRPIPISPSALSGPNDDDDYSAWLVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFH1</accession>
    <name>A0A2T4CFH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thioredoxin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1418907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFH1"/>
    <dbReference type="STRING" id="983965.A0A2T4CFH1"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015532660" evidence="8">
        <location>
            <begin position="23"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="175"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="671" mass="76125" checksum="F5CEE3E373552F3B" modified="2018-07-18" version="1">MRLTSFFSGLAAFGLLSSPALADDEAEKTPAPTIFDSVEVPPLTELTPDNFEKEASKTKWLLVKHYSPYCHHCISYAPAFQTTYEYYYTSKPEGAGDTSFTDFYDFKFAAVNCIAYSDLCVENGVKLYPTTVLYENGKEVKSVTGGQNITFLSGLIEEALEKSKPGSRPRSLALPQPGDKERPKSAPETTPRSGTEEKKPKKPVATPNDDGVSVSLTAENFQRLVTMTQDPWFIKFYAPWCPHCQDMAPTWEQLAKSMKGKLNIGEVNCDKESRLCKDVGARAFPTILFFKGGERSEYEGLRGLGDFIKYAENAVDLASGVPDVDLAAFKALEQKEDVIFVYFYDHATTSEDFNALERLPLSLIGHAKLVKTKDPAMYERFKITTWPRFMVSREGRPTYYPPLTPNAMRDTHQVLDWMRSVWLPLVPELLVTNARQIMDNKIVVLGVLNRDDQESFQSALREMKSAANEWMDRQIQEFQLERKKLRDAKQMRIEEAEDRDDQRALRAAKAIHVDMSNSGRREVAFAWVDGVAWQRWIRTTYGIDVKDGERVIINDQDSRKYWDSTVTGNYILVSRTSILETLDKVVYTPQALKPKLTISSFEKIFFDIRVSFTEHPYLTLGCIVGIAFGVFSWLRGRSRRGRGHFRLEDSISIRDFKEGFLGGSNGNTKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFI4</accession>
    <name>A0A2T4CFI4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1121420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFI4"/>
    <dbReference type="STRING" id="983965.A0A2T4CFI4"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="166"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="812" mass="87834" checksum="DE1074271344CD8E" modified="2018-07-18" version="1">MQRVSAFLPSWDRRSSGSSSKTGSVFGWPNRSSQPPPPPNGLSKINTDAANSIQGKRVQREAFWPATLDLECDKAARILKSFCVDGYFAPTDTDRPMSPASTSSGTRTLDLIPKKIPKRIVQNAAGIAVFTCMRSGLWMTGSGGSGILIARKSDGTWSPPSGIMLHTPTLSFIIGVDVYDCVLVITSLAALESVSRPRVTLGEDVELRSGETVSLVSDESEINWKELGNTVLTYMKARGQQQLVNLHGCMLSERSNENERFYGSSDITHMDILAGNVARDVEETTALNEVLKVAEGRTDYDNSVINKVAAEPAPSDALITTSPPKALSMPSSPHTSFGIPQADDPDPFGVLALEMAGLEIREAGSRIRPTSSLFDINQAPMSPVAPSKFSRQSMDTFVSRSNRGSYVSMRTIRSQVTDAGTQTDTGNTPATSPSPGPSDSNGRVSPAYIASVKEEDEENEEDEAEEENLKKEVEEENTEDEDEETESVADGRQHRLSRDVAVGPDSADEAELSDSDAVSISESLLLEEDAMSHGELSEEEGPDADDGSDDDLPEDDMEGEEPVVFEVAAVQRTSTQMLSSRMIQARGNVVTIAKRVPPPLPTRSPARMSRIANKDAAGEGLDLQSPLSQAFSSDGEVEDKDADLSNIDAVAATEQEDQKQEGAHKAQGGHEEDGEDEADEEHEVHEEHEEHEEHEEHEAELSHGEESEAAAEPQHKPASPEKEDHVPAESSDASSNNKKHTSSIYTGVTEDRWSDHGSSVTTPTSERRFSLMEDKIVEEKPKKAVEEANETDASLPTPTEDATHRPAATVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFX6</accession>
    <name>A0A2T4CFX6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFX6"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="491" mass="54775" checksum="4D69C9D5FC855362" modified="2018-07-18" version="1">MTSRSDTIQRPARDDEAKATRSSSQEITKSRRRLNKPITAERRLQNCRAQRAYRQRKRERLRELEARVASLGHGKESELVSGQDEVTPLASLAPDLSQPREASSSALTPSIAASFLQPYSNTWSYDSGNAWLENLPLTSFATEMIGLPNTISSESRPIAGADTPDESFSALLNLAETEALTSTPSEDSPATNPTASSLLSTVTPASLYSTPSSHTNKKEIQIYRPSSRPLSSRPQLVRKWFQILPQSTRRLLSQLAKEGNFSFIDMISSSLLLVETSLINRNGQDLEGSELKTIERRLSEMRSVTSHVSSYSPYRNSLRIARFSYFAALFTNFSSLGFDFGLFLDERSVSPFCASSATEDAGMDASTTCSTHDVPLNLRPVPSQFTVPHHPYIDSLPFPTFRRRALAALAADPPLLDEDDLCLDLMLHDGLVCWGSASQDGMDHGTPWDGHSWEAKEWFLRKWKWLVGGQEGELWHSSRWWAAQRGERISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGC5</accession>
    <name>A0A2T4CGC5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1130303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGC5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGC5"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="749" mass="85392" checksum="5A716E7CD5634944" modified="2018-07-18" version="1">MAPSAIDDRLPQAPQEKTYPPAKIFPVKETKFEKFIEPQTDGRKKALEQPGNAAIVIDNGSSAVRAGWSFESGPRLNIPPIMAKYRDRKLGKTFSFAGSDCYADTTARGHIRNAFEAGTGIISNWDVAEHVLDYVFLKLGMNEADGAIDVPIVMTEAVANLPYSRKSMTEIIFECYGAPTLAYGIDSLFSYRHNKGKTGLVISSSHTSTHVIPVYNSKALLSQATRLNWGGYHNAEYLLKLIRLKYPAFTGKLNQSQAEHMIQDHCYVSTDYDNEIRNYLNWEGLEDRDIVIQYPYTEEVVVQKSQEELDRIAERKKESGRRLQEQAAKMRLEKLMKKEQDLEYYKNLQSRLTDETKKETRRLLDSHDLKDEAQLDRIIKELEKSIRKARTKDLGGDPEEEQEQPDFSLLDIPDEELDEAQLKQKRQQRLLKSNHEARARAKAEKEAEKARIAEAERLDQERRENDLEGWLEEKHQALQETLQKIKERDRLKQDLGNRKSLASQIRMKSIANLASDNPTKKRRRGGDDDNFGANDDDWGVYRQIAVGDNSDEEQEEEDLASTLKSLEQDLLKYDPNFTYDNTQEAQTVWSKSLLHAFARGPRPFDPSSQAELHQIHLNVERIRVPEVVFRPSIAGVDQAGIIEIAGDVLTQRLGGLPNRDDFLRDIFLTGGNTLFRNFDERVRDGLRALLPAEAPLRVRRAEDALLDAWKGAAGWVGTPAWRAAAISRDEYLEKGPEYIKEHDMGNSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGR3</accession>
    <name>A0A2T4CGR3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGR3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="69" mass="7641" checksum="9BB0A3AE0FEB2EC7" modified="2018-07-18" version="1">MQPLDAIFSSPRSAVAREQEESGSEDMEISSSELGRTICAARIAWLPREATMGKPPRFFAADTLFLRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH81</accession>
    <name>A0A2T4CH81_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nab2-like CCCH zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1366564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH81"/>
    <dbReference type="STRING" id="983965.A0A2T4CH81"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000001">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="497" mass="53924" checksum="25ED25BC2D42D8C9" modified="2018-07-18" version="1">MSVEIGLGTPLADALSAAIQPKLVEVGWGTGGGDESALAEYIILMLVNGKTQDQIAAELSGDLLNLPLDDPVVHDFSRWLFEQIHMLNAQGGQGNSGDSMGNTSQGDAAGAMDTEMGSSNTGELNAPTGPRSMRNGNGNIRGGRDKRMFGQMSKAMDRSNDNVLHRVRTQTGGERINTHGRAPPSGPRGGRGGLMRNQNNRGMPVGPMGGAPGAPGFPQWPMPQGHPSQLDVMALLEQQSQMMLELSQQMMNNGNRGFGHQRRGKSLFERTQDPRHKNNFRRGQGQAQGQPDANGEDSNMEGGAEGEDVDMGGKREPPNPDETVCKYNLHCTNKDCKFAHQSPAAPPGTSVDVNDVCSFGAACKNRKCVGRHPSPAARLAHQSEQDCKFFPNCQNPRCPFKHPSMPLCRNGADCTTPNCKFTHVKTKCRFNPCLNPTCAFAHEEGQQGGFKDKVWTPGQGQEHVSERKFVDENAEEQLIRPETENKQEMARDEEITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH97</accession>
    <name>A0A2T4CH97_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1322307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH97"/>
    <dbReference type="STRING" id="983965.A0A2T4CH97"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112567" checksum="E741D8C543B63D05" modified="2018-07-18" version="1">MNNLPDEIIHITQGFVPLSLLLTRLAQSTHNMVQDKIAELAKMPLPAAAMNGNTNYTQSAPDDTSNENIRKKAALLHFAQDMHAKWVKALVIVEWSRKASMVSKLIDLKYHIDQQRILYDATLDGMINVKRDLTYARIPSPDLKTALQVLSTGTAPWMPDLNYIEPPPLTTEEQLRGIGDLDTLLSLRLNLDDFDKIPPQFRNYTIESGRVTFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFRPSSTTLPDSLRTLLENCVNEALAKDGLTGCYQFLHEFVLTAKINELRRQALQLSRTSWTGTLAVERLNRAVAIQYWTSRSPATGLKSWVIVAVNSGRKQGGRPDPKASSHLVAKWYRDGKEVKDAEIQLNAEDLSAESLLNDIVGRHIEFILSSIHTGLLAAPRFKNRETGVVLNVSKSDPGASSLTLQVGYGGTVSLLIEPTSGAFAMKPHSKFSIQPELQLNNGKNPAEDGVTYLEHLRCAIIEDEVGRMGTARGWALRKSPINVDELRSITKMRRWSRALWLQHGGWGQTWFVGVILSLDGDEWWLIETDPTHPNGASKFHTRLPLSKGTPQLSGAFWDNLNQFAASMITQSVDMRELHRRRIKCQASGSIDLSLPPQVRIPAIEVALSAIFPSILPNDTEEAASQNSSNLELYSDRDMLALLRSKAGISSSAKEPWAENVVAIKFKRADSEVRQATGDGGHIIHDLICTSEVAIKVRRPMKFLALEGLKSRDVCYSVGTSEFILRVKRRATEPIFDILKSRIKAIDRFVNFLEAMEKAKGSITSPSMTLKKEDGASAAPATPEQWRVQLDLSSDDIDIHMDPNNPHLKVIDIARTLANSEDGIGLLMVWLPITFYAVKAIKELDAQWLEPSMKELGRLDFSMESMGWILIKYNTFTKGRNNGEGPLKKVVCLQLRIRPRRGEGWWHAQRVAAAGPPPPDDEFDQALKTVWNGKGKHWVGLSSGAAAAANEGVMEMLFAIDGAIRVVVNATPGNGVKREVIALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHC2</accession>
    <name>A0A2T4CHC2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHC2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8538" checksum="330D333A0E21E559" modified="2018-07-18" version="1">MMGAQNCLMWTAWSACKRKQVHEPESGRDMGLDISEAYICMLVLVVYLPTGPFSPSLAPTFSLMQNPSAVCLGPLSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHJ9</accession>
    <name>A0A2T4CHJ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1004766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHJ9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="135" mass="14159" checksum="83C513EA2E413228" modified="2018-07-18" version="1">MSSESVDRHGRVPSHHYLAQRLPAGAVFSASSIDHRSIESPPCPGGNSQRGGGEASRDSLRFVLQQRANLVAAFTAAALQSLVVPLLFPGGALRVRLFCVSSCSSSSSFTSPLPGLAPSTKRIAACRNADPREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHN9</accession>
    <name>A0A2T4CHN9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1417823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHN9"/>
    <dbReference type="STRING" id="983965.A0A2T4CHN9"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1245" mass="132608" checksum="D28EB0FEB12DEA89" modified="2018-07-18" version="1">MAGSADEAGYTPLYAADSSLPDEAGIRAFISDFYRISDRPEENERWVGQFTADARVVIGPGKATGTDELRTMREGMWSAVAKRKHTVAKVFPGRFEDAAESDRRSKKERKHAKHSGGIAAAVTKQTAGKFARPVNDGDESGNDSAKSIPTSNASSPPINTPEIRPAAAPDNENPEPSPSLDVLSTTSVSASTAPSVIHDWARSGMAASPSNLIALAGESPPTQPSSYEDAGRLHHGWTAQRAFMTPSPASPSPPTSHPRRPLSYQMDPHFVSPDNMPRPSSTAAHHRRSSLHSPAPYSHNTHSRIGSHPPPLPFQPQAHFYGVSDLDLTLKPQSGMKPGDHGLYFGFDKLPAPYSAAASDNVVLAGYQGGLEVYGVSKRGLEHIASLKGLRGGVHYAKILPWTVGGDKDSVFPLVALVVHGPVLPQRPASAANPDDDDDEIKADGATSPRSAYAHHDAFSGRGGQSGQVIEAYQTAIEIYSLRTNKLVDVLLQAPTIPISAEVSLTSPIFQPPPPTGAFAIKADAGTVAVCSGATGECWLYTQLLQPQNGHVFACTAKLWTCIQQGQRGGDVAEESDKMNPLGTSRRSNPPTAILALNGRRIAYCPAAPSSSIAIRAHLPVPVLGRGAGVTSHTPPHLPSPTAAVDLPISDSVVNKVMREATQELIQGAKWVGQQGLQAWNSYWNRSSSPQSQQSQQAQQQQPRSPPQQWAARNDGAAFPPTHGTSGQAAPTKDPGLVSIVDVDSLVTSPSVHPICTFATPLGCSFLSFSPSSLALFTASSKGDVQTVWDLLRVQHTHSSPLQASLPSHESVGPLVRQIAQFSRMTVARIIEVVWTEPQGERLAMVTERGTVHLLEMPFSAFMWPPPRRRKVTTTQKPSVEPPEPSSSAVSLASGAFGAAYQAAMPFVTRSRQGSSNSSNTAGSILKDSAAQGGRAIAASITSSLGKTGSAISQLRNTGENRVSLPPGGALPSASCVVWIRGRRSAALFNLGGGLVRTYPSKARRHAGHAGGRRNARANRYTDYRVPLLPDDTVAPAVRQVLELGAQEEYLDLSDTEMDVGTTLTLKGRPRAVPNTLHTMGETIPQAEIECSAPYQPFHTDRRVILCEYTPGYGSQLDGMSEALAHSSLDANAPSMSKKAKKGQSAAAANAPSGAPDASAWAFGQDISVVKLDVGLPSAFEDEYADPEDHRPLPPSAMERVMEYGDSEQIVVTTRRRRSAHQGDPDGDGFFEDDCEVLDFADQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHP8</accession>
    <name>A0A2T4CHP8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hydrogen voltage-gated channel 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1396224</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHP8"/>
    <dbReference type="STRING" id="983965.A0A2T4CHP8"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="75"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB81064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="218" mass="24502" checksum="554FE8284D46881C" modified="2018-07-18" version="1">MAHRSPPPLLQPYRDDDDDDSDDSRASQLSPSSPPSRTRYWRQCRKSSRRFLESRTKHFAVMSVVALDVAALLANVFIQLIACEMHQNDEPWVERVTEGLEIAGLVFSSLFLLELFACLFAFGPSYLASWFHLFDSAVIIASFIIDVTSRGLTESIGSLIVVLRLWRLAKISEEVVLGATERMEVLEQQLEDLEAENSRLRAQLGIESSNHSGNEGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIB9</accession>
    <name>A0A2T4CIB9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1435106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIB9"/>
    <dbReference type="STRING" id="983965.A0A2T4CIB9"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000684">
        <property type="entry name" value="Putative glycine-rich RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="18625" checksum="C22E5D31992B3F52" modified="2018-07-18" version="1">MSKLFIGGLAWHTEEATLRQKFEEFGPVEEAVVVKDRDTGRSRGFGFVRYVQEADAQAAIAAMNNVEFDGRTIRVDKASDNGPRGERFGNRNGGMYGARAGYGTPPGSYGNAAPPGYGVAPNMYPPAPYGRGFPQQQQQPYGMPPQGYGVPSYGGYPNLPQQPQQPPQGGGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIV7</accession>
    <name>A0A2T4CIV7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1387913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIV7"/>
    <dbReference type="STRING" id="983965.A0A2T4CIV7"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="572" mass="63726" checksum="88C2DB5DE8206BEA" modified="2018-07-18" version="1">MEQDMASVVNTGTSSGSGSKQIPLLCTVCPESPRFSDVSHLLTHIASKGHLHHETQTKLKAHQDVSASVSLQQYEQWYKDNGIERLLVERMKAKQLKEAARNKRARGVAALAASKPKRKMKRVESDMVVKNEREDFTPDFPMFPGFFQSDHDNEVQDDFFGSGDMMSLKGQIWPGMGKMDLANEDMKRTRNQRKPKSVIEKMRRTSEGIEPTQVVMTAEFEVERIKDVYDSSSPAPDQEETTPPKKTVKPRRKRGEPLAEISANIPRGGNRRLTRNNAGQEKTSKPLLAYSRTPSSELTPTLGQYKRSHDIFRDDDEYTGVYDGRAVSNASQREPSFDLRRRMGLHQLNPIAHSNMASPTPTARDIPDRGFSARDLQRSRGQEQSFLSMDGHAGLGSFTHQDLSYPMDGTSIYNSAPRFPFATNNHFNALGHDSFRLPSGHGAQPKFDDYSHTSAGEVNTVANQFLDIPGTNPLFSQARLFLGSCGQSGPAASLSPLGFTSINRNPDASHSMRQSQSAAGVKPEPQLCDVLDDGNLEDEKESRYPVHGIWESQGSDNGIEIHEELQHDELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIZ3</accession>
    <name>A0A2T4CIZ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1418175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIZ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CIZ3"/>
    <dbReference type="OrthoDB" id="5153609at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="79" mass="8591" checksum="3D6BB37746036EAB" modified="2018-07-18" version="1" fragment="single">MERSRGVPDSELFLSKPAPEDCDSPTVEPLRIFKPQSPEPYSRVSSTSSNRPTFPLPPGASSSAAPLPFPDDDDIHKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ43</accession>
    <name>A0A2T4CJ43_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1321643</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ43"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ43"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015532663" description="chitinase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="16">
        <location>
            <begin position="10"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB81563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="380" mass="39645" checksum="3031E1AA818EBE9E" modified="2018-07-18" version="1">MRRAASVACAAIAALALPGAVLAQTWSQCNPLKSSGCPADTALGMTINVDFTKGAVNSFVASGSPTYDSNGVSFTVAHAGDAPQLASVFYIMFGRVEVTMKAAPGAGMVSSLVLQSDDLDEIDLEWLGAESDQVQSNYFGKGQTTTYNRGQFHSVSGTQTEWIKYTIDWTQDRIIWMAGDSVLRTLTPDNAESNQYPQTPMQVKFGSWAGGDPNTNAPGTVKWAMGPIDYSKGPFSMMVQSITVSDYSTGKQYVYGDSSGSWQSIQAVGGQVNGNTGNKNVLTVTASNSNAGSTPTIVLSIPVGGIGTDKSPATATQTGWPWVAGATPTSGTIPSGWHMNPDGKIARNAAAASAGVPVQTLLVLLLSHLLIGALAFAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJB4</accession>
    <name>A0A2T4CJB4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1418258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJB4"/>
    <dbReference type="STRING" id="983965.A0A2T4CJB4"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="70"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="481" mass="52885" checksum="6DAF3E79F628B13D" modified="2018-07-18" version="1">MLQRLAIPAAKLLRRRSHLVPGQLLVTEHFFQVPLDYANPSASTITLFARSATKHESPIVLPDEPPSPRPWLVFLEGGPGFGNREPQDHPLTRVALAHGYQVLYLDHRGVGLSTPVSAEMLARLPAGQGQGPDAVDVQAGYLKLMRQDNTVRDCEAVRKLLTEGLPEHKARWSIFGQSYGGFVSISYLSLHPEGLREAFLTGGLAPVGKTADELYQATFRKTIERNAAYYQKYPEDVEVVRQIAAYIEKEGGEQGLPLPGGGFLTVPRLLTIGIALGFHGGIDQIHALLLQLKSSLDQLGFLPRAALAPLESFTPFDTNPIYAVLQEALYCDGPGSVSNWAAYRVGKALSQFSWLARDNTSTASSAPAGQPLLFSGEMVFPLHFETYPELIALRAVAERLATASDWPALYDVEQLRKNEVPVYAAVFKHDMYVDYGLSMDTAALIKGTKTFETNVMYHNALRAKAEEVLQSLFALRDDVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP61</accession>
    <name>A0A2T4BP61_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1395928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP61"/>
    <dbReference type="STRING" id="983965.A0A2T4BP61"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015544244" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="80"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="423" mass="46608" checksum="C470AC52F65AB55C" modified="2018-07-18" version="1">MEPSRAPLSVLPLSMILRSLATTVVSSSPILLPPSLRIMVALAHAKSPILNPDKNPVLKYFLKKSFYAQFCAGENAVEVRETICRLKNIGFTGVILGYAKEVVLEGSDARNTSAAKLSEETARDIEKEINPWRDGTLETVRLAEPGDFVALKFTGAGSLALNQLKNRLPPSPHLSESIDAICQLARDRGVRLLFDAEQDMLQDGIDDWTMHFARKYNNSPDTATIYGTYQAYKKACPAVVSRHLADAQREGFTLGVKLVRGAYLGSDPRECFHDTKEDTDACYNSIAASILTRQWSPTVQGQGEFPNVHIVLATHNVESVRRARAICDAGGAKSDIAFAQLQGMADEVSCELVEASQSAQKENANARPLPVYKYLVWGTTGECMKYLLRRAQENKDAVQRTRNGRDAMWAELVRRCKTAVGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPI2</accession>
    <name>A0A2T4BPI2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1387060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPI2"/>
    <dbReference type="STRING" id="983965.A0A2T4BPI2"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="89"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="15">
        <location>
            <begin position="409"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="346"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="550"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB71214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="695" mass="79415" checksum="B5A246B8DB7357D6" modified="2018-07-18" version="1">MSQDTNLWSVRRKRETLGGLSTNSGIPAPGSTMKRSNSNLGHSGYGAGHARSMSGSRHSLALTRPNQPMFQRASSGASLADLGLSSSTVGPISHQSFFQTTPQAAGMPRDPRPLRDRAFQARIAQELMDYMVQHNFEMEMKHSLSQNILKSPTQKDFNYMFQWLYHRIDPSHKFQKNIDQEVPPILKQLRYPFERSITKSQIAAVGGQNWSTFLGLLHWMMQLAKMLEGYANNQYMDACLEAGVDVTGDHIIFAFLSNAYRDWLAMDDDMGDEDAERLLAPHVEAMAKAFEQSNSRYTAELEMLEAENERLLKEIEDLEKSTPDPAVLDNHFRIMEEDRVKFEDYNELAIQRSEKYEARIQVLQGELEKLMEELKEADEERRGLQKAVDDQGISMQDIDRMTSERERLQRGIESAGQRLEEIKKKVMEKEAEASRRLDELERMVDRYNTIAYQIALIPATAANAKGREYELQVTLNGSELGSSNWKSSSTTHTPATDRLLIDATTGYQPGHVLNLDLRGSIRSSFIALRKEIAERRSAVMDDMMKDHDLLDGIKEAIEDKRNEVEALNHRVRAAEEEYEKTKEVATAQKMGSDAQIEKMEKELSRMRAGLTESVQLLEQREINTTIEYEQLVLRANSLREELHTEIDRMLNDVIKFKIHVQKSLDDYEGFVADELEKELGGDEMMMDETRTLPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPT5</accession>
    <name>A0A2T4BPT5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1473639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BPT5"/>
    <dbReference type="OrthoDB" id="4900688at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32087" checksum="F99ECFF8E96EFB05" modified="2018-07-18" version="1">MGNLSKKRARRASQQSQRPGKVHKGPAQTVPRSWTAMITRPSTNQLPQTETPDYLHETANEFTEEKWPRHIVRDLMPFICVMESCPIPNAMFDSFEEWTQHMEQHHRQSGWVCRCGGNTFYFHDEGEYMRHMVYSHGVDPVEDWEALTEDNAELLPFRPLERCPFCDYYDNTVGCEDVNEHIARHLLSLAQLSLPEDFLPTKGHEGECTVEHDQASSDTRFQNYLRRRELSTSEDENMSDGGTPQSMEDDDLDSGTQDTVYSVAQDDPERLCRKNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ58</accession>
    <name>A0A2T4BQ58_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1344309</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BQ58"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="328"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1307"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1341"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1378"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1390"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1409"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB71420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1658" mass="183646" checksum="B1FE5F3927B607D5" modified="2018-07-18" version="1">MNIAQPVASEVESVEFTFLSAKEIQAISVKRIENESTFDNLLNPVPGGLYDPALGSWGDAPCATCNLNQNNCPGHPGHIQLPVPVYHPVFLDQAYRLLRATCVYCKGFRLPPKDLHKYTCQLRLLHHGLIHEAHMVATIGENDLAVEIREAIGEGDSEAEEDNSGSDGVTRQREKYVRQCLQGIKMKRGEAKKGKHEGATEMRREIIKEFLAEIIKKRECSSCGGISPTYRKDRFVKVFEKALSAKEKAKMAQKALKFGDAMTRDIEMGDADQYDEDDDIPEEGAQRYISSMEVRARLEELFRKEQDLLSLVYNAKPPTQSSQKVTPDMFFITVVLVPPNRFRPEARTGDSQISEAQQNALYKNILGCCSKIARVYKGLEDKTSDMASMHQAWTELQDAVNSLIDKNKNPVQGAAAARTEDGIKQLLEKKEGLFRKNMMGKRVNYAARSVISPDPNIETNEIGVPPVFAKKLTYPEPVTSHNFKDMQQAVINGVDKWPGAFAIENENGQIVNLRNKSVDDRISLANQLLAPTNSNSARTRNKKVHRHLTNGDVVLMNRQPTLHKPSIMGHRVRVLPGEKTIRMHYANCNTYNADFDGDEMNMHFPQNEVARVEALQIADTDHQYLSGTAGKPLRGLIQDHISVSVALCSRDTFFNRSDYQQLIYSALRPESGHILGERIQLAPPAIIKPVPRWTGKQVISTILANMRPPNCGGLTMAENAQLKAEQWGKGSEEGVVLIQDGEFITGILDKSQIGPSSSGMIHAVHEIYGPAIAGKLLSALGRLLTRYLGMRAFSCGMDDLRLTAEGEAARRRELLAADKLGLKIASSYVSLENQENAQNPLLLERLEEVMRDDSKQEGLDLLMNQGSKDITDAVQKALIPNGLAKNFPKNQMQVMTTSGAKGSRVNASLISCNLGQQVLEGRRVPVMVSGKTLPSFKPFDTNIRAGGYIVNRFLTGIRPQEYYFHHMAGREGLIDTAVKTSRSGYLQRCIIKGMEGLTVNYDTSVRDADGSLIQFLYGEDGLDVTKQNYLKDFRFILQNVTSEAAQLKYDPKVGERLGSNRQAFQKYMKSAVRHAKAGDRKAKDPLTASFDPATNAFATSETFYEAMTDYIRENPDGLVREKNSQDKAPLQKVTLNKKNAEMLFAMKYLRSLVEPGEAVGIVAGQSVGEPSTQMTLNTFHLAGHSAKNVTLGIPRLREILMTASRTISTPAMTLYPNPELSERDTEIFAKSISVLRLSQVLDGIVVEELVGKGKLRGLAKIYKIKLKFFPGAEYSATYAVTVSDIMTTVEKKLLRNILAILKREVKKRQSQSTTATPEVGVKAGVVETARPEGAAEGGRGDDDDDADEDDDDDATGAKNRANRSEAISYGPNDEDDDAIQKDLSKGADYDVSDDDDEDAAPSTRKKERDDDDEDNEDDDDNDNDNKTPQSWSAKLRTERVLNAYAEVTDFQCDDRGGEWCNVTLEFDVNIPKVLMLNIVEDAVRQTVVQQVAGVESCLVSQEKGKTVINTTGVNLRAMQRYSDFIDPHRIQTNDIAAVLDVYGVEACRGNIVQELSGVFGGHGIKVDNRHLNLIADHMTRNGDFTAFSRMGLRGNVSPFTKMSFETTLGFLKDALMDGDWDDLTTPSSRLVMGKLGRVGTGGFDVLTQLPTYYVNALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ78</accession>
    <name>A0A2T4BQ78_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_213577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ78"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="215" mass="25466" checksum="FB7D0B88B94DAE1A" modified="2018-07-18" version="1">MSHWPPSRPGRPPSLFCVSSFATTFHFNAYTTRHDLHFYRFFLWNPSYPPFRPFSFTLRRQVSQQQMDITKVKTETPPGPLRWWPCHLFYHGPFAFGIWRAGCFYFFSSSIRLCLFFVSIYLTFLHDEVCLFLMNVWAVGSDLIDEYVCAGERNASCHDQDFCVLLLSSSQTCCSRIHNLHMRWTRREASRLKSKRWREIRDGNASSLLYLFLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQD5</accession>
    <name>A0A2T4BQD5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1395643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQD5"/>
    <dbReference type="STRING" id="983965.A0A2T4BQD5"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="455" mass="48587" checksum="CCD1FE73B7A22ED2" modified="2018-07-18" version="1">MRDMDGVDELTARDAWASIPSHLLRAELQRRRDEGERPQCGGHNSGWYDTAAHIFALLLILVLSTLACGFPLLSRRATTGHRQKNIVFYCQHIGTGVLLATAFVHLLPTAFSSLTDPCLPYFFSKGYTPFPGLIAMVSAIVVVGVESYLTARGAGHSHSHAHDFWDEDEQDDAQELSATAVNGMAGRRGHVAGRRPADISLDNLEASEGLMAGVSPLPESSPAMLRRRSADNDDEDDRDSDLDLDLAELDPVSAGGSAQNGAYSSLSRVKTNARGGGGGEASDGNQVQSPEEQKRRMLQCLLLEAGILFHSVFIGMAISVATGPAFVVFLVAISFHQSFEGMALGSRIAAIQFPKGSVRPWLMVLAYGTTTPIGQAIGLVLQRKWDPGSATGLVVVGTTNAISSGLLLYAGLVQLLAEDFLTEKSYRVLKGKRRVQAYFSVVAGAALMAAVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQN3</accession>
    <name>A0A2T4BQN3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQN3"/>
    <dbReference type="STRING" id="983965.A0A2T4BQN3"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32952" checksum="078D344DACCDF76C" modified="2018-07-18" version="1">MAAPLRNTSLTGPLPRSLPGASVRRITTFGPANAPAQPVARPPAEAAPGRQQPLPDALLLRRVKSETRSSLPRTYFESTGAVRGRGDQPPDPNKAKLGRTLRILQEHLPTLLQSPLPQDILAPNISLRLFPSTHPHLPAVSGRVAYTAALWTSPIAWNRVPIIGNVRLEILAERVTSEPLTFLPRRAGAIPEQLVVRWCEKRRSKDESSESESGSGISLPSLRLARGVDPHKAFTGLFIFDFDAEGRILTHTIEHAQEGGDWEKGMGAKFVGLTDWLLGGGMRNSGDTPIPMFESKRRWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR42</accession>
    <name>A0A2T4BR42_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1141856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR42"/>
    <dbReference type="STRING" id="983965.A0A2T4BR42"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="134" mass="14471" checksum="8EE67A9933EB1C65" modified="2018-07-18" version="1">MESRDRSYIPRPAMCDMALESSNVLTSGVSGDAELIELYDVEIRNSIPRSKEKKLSSRSSKSKGATITAKWACYSPAGWRCNASGSLRVIFGDAAGDHETLPRRVAPLASLSSVETERSCTSLTETGVIQIGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRI9</accession>
    <name>A0A2T4BRI9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1101853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRI9"/>
    <dbReference type="OrthoDB" id="3941926at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="820"/>
        </location>
    </feature>
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        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
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        <location>
            <begin position="860"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1139" mass="123537" checksum="146A65050BD49E7A" modified="2018-07-18" version="1">MQDTAAMKPFHSSQRHRRSTQDARYYADSFPNGYIRPNAGLPFKPSTEPTPFYMQPEKDFVPPHLASTNKFPHQREHLSSAANKQLPHSAPYREFSGASQVAPHQQFANGTHSSVVPSVKMRNPPVSSTDENIPPLQATRPETFHGSSTASSQTGYNNHSRMHYKAGQRRGSQGQKTHGYNQAQADHHAMPHEPYPNKSWRRGAQQDDVRQSSWCRNPVGSNYMDYIPCSCSGCEERNRSVWIGVTHDARLQRMEIQAFLKFGLSGKFGQIEEVCPAASLNKDAFIVRFVTEASVSLALSFGGGLIPEKNMRLLIRPVHRSKWMKNLPYQQPRPLPPVPVTHQQPAWMGKASSSSTLGHGHTAASSPSSVPSPTQSLERGQPATSTSPKSAEVLPQAIVSGESSIQEASVPKSEAPIVSPRSDQSRQVLASTVTHDQAASREKESPSGGKHEDLSKPGHASPQTTTPVQTKKEKKKDVAVRPKSPLDDTMSREPNACVSTMPPGEDDSCALTEKARVVLSNSLLEPSITAANETSKSEPSVAPNSDVGTGSGTSGSQGRQVSEHPSPERAGSSHAMAHINNTDVRGSARSAKGNKQAKGSSTEAHAPAPRAVVDSQAAVPRPSENRTEPAYTGNHMRNSSIYTAEEIRERRQAWNRIPMPLDPRKFKKAGSNAGASQPATPRTSAPEETENNGDSTPSAGEKTHIVPLESLSTSHQGLVPSREGLEVSDEERVRRSMSEQRPISPKGPSLESQNVPRTTGEDAFDPPLKSPASSSWASELVDDTSTGSGLGQISAANSTANQQGKAKSKWNKNKKPKKRAAPAPLNALQRDDDSQGRPPSDLDINTTSLKENHGVHHDSLTPTTATSESFPRPASATEGLGKMSSKPLRELQEQGTTSFRGQYHYDTLPRGRLDFRQNAGGSLKVSKKRKNKYPSINSRTFEPATSGRSMPSPTKHAADGQGASTIDSATKVEVSDPSRKSRLNPLATAFESPRKGAATALGTETSPNYSRATSSRAGPQDGSLNQPQSPSKIRLMQRPVTAHSSPTKSPQLRERLNRGFTGVDDNTEIPILKKQQENNPPGKRRDEIGDRRRHERENKKPVKSSSTSPKREDGKTQADFDAAEWPALPAARVRSATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS50</accession>
    <name>A0A2T4BS50_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1434017</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS50"/>
    <dbReference type="STRING" id="983965.A0A2T4BS50"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="290"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="509"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PTB72129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="738" mass="82921" checksum="87A90B6D5BBD3505" modified="2018-07-18" version="1">MPEFPEADTIRILVATDNHIGYEERDAIRKDDSWRTFDEIMTIARTQDVDMVLLAGDLFHDNKPSRKSLYQVIRTLRKNCLGMKPCPLEFLSDAAEVFQGAFPHVNYEDPDINISIPVFSIHGNHDDPSGDGNYCSLDLLQAAGLLNYYGRVPEVDNIEAKPILLQKGDTKLALYGLSNVRDERMFRTFRDHKVKWYRPGQQTGEWFNLLAVHQNHHAHTATSYLPENVLPDWLDLVVWGHEHECLIDPTKNPETGFHVMQPGSSVATSLVPGEAVAKHVAVVSVNSKSFKVDKIPLKTVRPFVTRDISLSHDKRFKGLDKKKDNKHEVTRLLMEIVEEMIATANAEWEAIQTDEEALEERPLPLIRLRVEYTAPEGGEFECENPQRFSNRFLGKVANTNDVVYYYRSKKSSSGKKEAKPADILEALGDDATEMVKVESLVNQLLAKQSLKVLPQGPFGEAVNQFVAKDDKHAMELFVSHHLSNQVKQMMNLESDDEDLNHAMQLYKEKAEQMAAASSNRKSAPQERKRVLKPKPATWDSDFDGNWEDEPNAWEYEDAAEEDEPPARPRAAGRSSRKTQQDDEMLDVDEEEPPPAETKKATTRAPKAPAKKAPAKKAPAKKAPARRGRDLFEDSEEEEEEPQKEFDEVMDSDEGEAPPPPYTATRVGRGRNAKPAAAASKPAATRKTPARGAAAKSRQTKLNFSQGATQDKALEISDDEVSDDDAFEPAPVASRTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS71</accession>
    <name>A0A2T4BS71_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1100441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS71"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015554912" description="Peptidase M20 domain-containing protein 2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="52960" checksum="2720FDB45CAED07B" modified="2018-07-18" version="1">MHLSSTILMAAAGAAAQSTFDLSDLPAFIKSSSSTNWPTLLNIGQQIWNDPEVGLNETHAHDRIVKYFSSVGGWTVSPSAYPGLPTAFKAEFDNRPAGFTGELPTVGFLAEYDALVGIGHACGHNLIALNGMSAAKFASEALAHYQIPGRIIVIGTPDEENAAGKFKLNNLGAFNGSDVWLMAHPTVTSAIQPMNARLNYFARFVGSTHSEAVSKAYDALDIVQNLSGLPGTSSSAVGIENVGVYATNIVQSIIKLGVAGLSLDTVNSTVSSILDSTYPNVTFSAVTDADGVALTMLGPGGHASEATKSPLTLSVNTYNALKNSSGVSFYLPGNTSVTELDITIDFRTRYTADLNSVANFASAALGTLPAGISHDVQYPALEVTPFLGQAFIDIVGTPDYGLTNFPATTLAPASTDASWVQDPVLDPVTHELKSAAKAVLHANYGICTNPSGAGCPFNHEPLFKGLANTDFAYQQTEIVARAEAQLAVELLADPSQMAQAVAIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSH5</accession>
    <name>A0A2T4BSH5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1405645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSH5"/>
    <dbReference type="STRING" id="983965.A0A2T4BSH5"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="138"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="363" mass="39546" checksum="347DB17485E737EA" modified="2018-07-18" version="1">MASKTFNVGIVGYGLSAKVFHIPFVTSTPGLKLHAIVQRSPKPNDSAPADHPDLKHYTSTDDLIADTSVDVIIVTTPPDNHFDLTKKALEAGKHVLTEKPFVPTAAEAQKLADIAKQAGRLICVYQNRRWDADFLLAKHLISTGALGRVLEFNTHFDRYRADAPANWKGQLGISKGGSALFDLGTHLIDQAYVLFGLPQSVHGRLLNQREGRPEFETPDAVVAQLTYPNGLLVNVNISALSAEVDQLRYWIRGTKGSFRKVHLDPQEDFLRAGGKPTDAGYGIESTDKSSLTAVDEATGKASRVPVPELEPETYRAFFAQFAKALQSGKAEDVPVKAEEARDVLRIIEAVLESAKTGKDVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSK1</accession>
    <name>A0A2T4BSK1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1472936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSK1"/>
    <dbReference type="OrthoDB" id="4898996at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015774899" evidence="2">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="279" mass="28542" checksum="9FBFB2BB3FFE0169" modified="2018-07-18" version="1">MVCKSVLAGLVLAAFASAVPNELEKRSSLILPAPPWRGSAVLPPSAIYETPTETPSWEDDDDKGYSTPKPDPYSDETWSPYPLPTNTAEPSPSTPRPSYSAIVSVRTTTWVVSHSTTITSVILETYYSTLTDYGDGSAEGGSGTVTVTTTSVVKTETESGSAASASDPCAAGGLSKYASECSSGTPVTTITWTPALTPYPLPSSSEDEGRAPASTSSTTTSTTTTTASTTTATEADTESPTGISTANESPPVVTGAATPLHNTNTRALAAAAALFAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTB7</accession>
    <name>A0A2T4BTB7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1341837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BTB7"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="344"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="628"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="904"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="967"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="820"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1314"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1357" mass="150070" checksum="43224E6E22409F94" modified="2018-07-18" version="1">MRRLTTAFAPASDDVPELPPPPSQPDDEAADPQSRPQSRESVASLDRPSTPPVQQQSNKHRRFSVLRFRNASDSQLSLRVKQAAEKPPPVPRPPAIITTAPTVNMEPNSIRKSSSRLGLAAMLRRSADIPRDDPVTSHRREPMPRKSMGDQGRPSLSVADDADPQSPRPSTQTTSLSSTSFFKLRRNKRPPEPLFPFAHLQQKGGVTPANGNSTSSLGVEATPRPASAQSTGLHKAETDHGPHPNPAIALFNANAAPRSDHSSPTRTTLLRGRSSTLSSIGRDSNDEHLGPPVNSRTSTSIGRKSFGDLLGLTRLRQNSDLSRQGSFTPATPGSTGSKNNSLQLPRDSIVLPERLEDESPAKYIARIEGMVSRGAIAAALSKGTDAFSTAALRSFMRTFSFFGDPMDMAIRKLLMEVELPKETQQIDRFLQAFANRYHECNPGIYSSPDQAYFIAFSLLILHTDVFNKNNKHKMQKADYLKNTRGEGIFDEILECFYDNICYTPFIHVEDDLESNHERPGGLKSKRKILPAPPGDPAKRAAKEPLDPYTLIIDGNLDVLRPNLKSAIPLEDQYCYLGPGQTLNLKDLQKTFFRTGVLQIVSARSRPDAFMSDKPLNNPDDAPGIVDIKITKVGLLWRKEAKKRKTRSPWQEWGAILTGAQLYFFRNTGWVKSLMHQYESHVKAGHDGIPITFKPPLEEFKPDALMSTKGAVALLDTSYKKHKNAFIYVRQGGLDEVLLADDEQELHDWLAKLNYAAAFRTSGVKMRGVAGGTYDGHSRRAFRRLESSDATQLVETPTGLVSIARSRIDHKMAEDIQQARREIMRQKIAEADRKIEEAKKALEDQLRNARHLQILAPIQPRTREQLLLAAARMSAQLRWARMEIWKEKCHRDILALDLQEEGELIENQPTADTRPSVEERRVSSAPHPSGSVSRRPESKAMSEKLPQSPLVEAHPAFFSDKDDFTVELQDPARPTSPPSTRPTSEVHPQLEVQETPKLDIGSVRHGSVSSITPSPVQPSTSTTLGKQQLEPHDEDEAADVKSNHTHDEVDADERHFLRQAGLLEGRVGRDPSDKSITSTAGEAGEPSSSADKFERSKIRRSLQRTLRESAGHLSHHRSRKGRETGPTASAEDAARDSTLSRGTGSFVVHGKKASVIQLGTELQVLNNEEQLLARKSQQQSYRQSTDQPAFSPPSEEQEDDFYSVLEAPLEHSESRERRESAASASTATARSFRELHRKYSSAQATRSISAGGRLAVPSDADSEVAVSFSDGRRSPLPPIETEEDDDDDELEAYTAESAIDEEGDTTMELGQKYAASEHKPEDGTLKEEPVKEKEAEAEAEAAHDSEPPSNRPLQAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU26</accession>
    <name>A0A2T4BU26_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1341184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU26"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="629" mass="68841" checksum="8903C14365686E24" modified="2018-07-18" version="1">MPDPDPDIVSALLTRQTYNADADHVADGPTRERGTAEILSGVAPIESEELGVTLDRLHDDIEKAPLEGPDGREPTEEERTTLRKVAGSIPAISWVLCVAELAERASYYGASQVFNDFMQFPLPKGGNGSGAVPKSNPNGHAGALNEGLQFASAFSTLFTFLAYVFPILGAYIADTRLGRFKTILLGVIIGAVAHVIMIGGAAPSLLKAGKGLAPFIISFFTLAIGAGIFKPNVAPTVIDQYTNQRPAIKTLKTGEKVIVDPERTIQRVMLIFYAMINVGAFFAIATTYTEKYVGFWLSFLLPGIVYFLLPFLLLGVYKRLVIKKPDGSELTNFFKIVWASLKYNKFQVWKKDYWAVATPSKLAERGIQVTWTDRAVLDVQRTFEACVIFLYFPIYNINDGGVGAVQSNQGASMTNNGAPTDLLGNFNPLTIIAVAPILSYGVYPLLARYGIKFGPIRRMTFGFMLAAISGAIGAIVQWRVYETSPCGYEASTCDDVSPINIWWQIPNVALGAISELFCNVTAYEMAYARSPPHLKSVVMSLFLFTTALSSALGEILIPAIVDPHLIWVWAGPAIALFVQTIVFWIRHHKLDDDVYMLEQETPNQSQAQLTQTADLEPGQETVVRDGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUG5</accession>
    <name>A0A2T4BUG5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TMS membrane protein/tumor differentially expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1441258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUG5"/>
    <dbReference type="STRING" id="983965.A0A2T4BUG5"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015623345" evidence="8">
        <location>
            <begin position="18"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="476" mass="52163" checksum="B7F8D614501284A3" modified="2018-07-18" version="1">MGALLSLPLLAVPSVGTIVSCFASCCGAATCSMVCSACGKCGNSIATRIAYALLLLVNSILAWIMLTDWAIEKLQHLALDYVKINCPTGQCYGWLAAHRINFALGLLHLIFAGLLFGVKSSKSPRAAIQNGYWGPKIIAWLALIVMSFLIPDRFFMFWGNYVSFAAAMLFLVLGLILLVDLAHTWAEYCLAQIEETDSRFWRFVLVGSTLGMYLASIAMTVVQYIFFAQGGCTMNQAAITVNLLLWIIISIVSINPTVQEYNPKAGLAQAAMVAVYCTYLTMSAVSMEPDDKNCNPLVRAQGTRTTSVVIGAIVTMLTVAYTTTRAATQSLGLGGNGDAIRLPEDDEHDLVTQQPMERRAMRAEVLRRAVEEGSLPADALLSDDESDDGGDHPHDDERSSTQYNYSMFHIIFFLATAWVSTLLTLNYEEATRDGQFATVGRTYGASWVKIVSAWICHGMYIWTLVAPILLPDRFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUI0</accession>
    <name>A0A2T4BUI0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1441249</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUI0"/>
    <dbReference type="STRING" id="983965.A0A2T4BUI0"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="993"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="13">
        <location>
            <begin position="94"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="14">
        <location>
            <begin position="689"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB72948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114372" checksum="4B7538E677B539A7" modified="2018-07-18" version="1">MTTTKQPPSAALGARSRGLWFLSILCFLVATAGVGLLVAIFRSLTTRQIEPKGCRMSYMRPSYIHFSEFDTEHTRFASKYSLYLYREQGIDGGQLRGIPVLFIPGNAGSYKQVRPIAAETANYFHDYLQHDRSQLESGVRSLDFFTVDFNEDITAFHGQTLLDQAEYLNEAVRYILSLYTEPQRVSRDSHLPDPTSVLILGHSMGGVVARAMLVQPNYQENSINTIITMSAPHARPPVTFDGRIVQIYDEINDYWRRAYTQKWASNNPLWHVTLVSIAGGNLDTVVPSDYASIESLVPETHGFTVFTSGIPTVWTSMDHQAILWCDQFRRVLAQTLYDIVDVHRASQTKPRAQRMRVFKKRLLTGLEPIAEKALSLSEPTILLTLDDSSSTVVPTGDRLVLSQLGSEAASRAYLLPVPPHGSLEPKRFTLLTDAQLNAPVDGNQLQVLLCSVASVSPILSSTVDLSKNGTTPTKFACKDAASDMVLLPASRTNIQAPFYLDGQSRIDPFSYLQYDAEHLSDHQFVAVIDRATGARPGFVVAEFSDHSSFQKKEDVGLSRLLTFGLSLRLPADRPLAMDIHIPVLKSSLIAYEMVINNQPCVGKPLLFAPLIRQYIQRPYESKFFVNARTTGISFHGVAPYMPPPLTSSGADGLSFGIWSDPTCKAPLEIDLYVDALGSLGKLYMRYRTVFAAFPLLIVTLVLRKQFRVYDTTGTFISFSEGLDLSLRQSIPLLLSCLTLLSLSPSRVTTFLAALVDSNQANPNLSSNISFHKNDLLIGTDDPLFIYLVPFIGIVCVGVCTVLHYVILALTRILGVAYAISTALPAINGNKPPGSLPAFAPSTPRRRVISTIILLFLVSTFIPYQFAYLVACLVQILTVVRALRIYVVTPSTANSNYYHYSHSILLLMMWVLPINLPILAVWVRNLAVHWLTPFSSHHNVLSIMPFILLVENLTTGKMVPQVTCGFRHITSGLLLGTALCAAIYGVSRAYMLHYLVNVVAGWLVILHSSTEPWSLMNFGMFLEGDANELEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW81</accession>
    <name>A0A2T4BW81_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1464982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW81"/>
    <dbReference type="STRING" id="983965.A0A2T4BW81"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="186" mass="20867" checksum="B8F81371A44AFB12" modified="2018-07-18" version="1">MKGLILVGGFGTRLRPLTLTLPKPLVEFCNKPMIVHQIEALVAAGVTDIVLAVNYRPEIMEKFLAEYEEKYNINIEFSVESEPLDTAGPLKLAERILGKDDSPFFVLNSDVICDYPFKELLEFHKAHGDEGTIVVTKVEEPSNVTFGVSGNRLAKHSWRDRDEGPGLRRAMTDEALKISMYEKMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWR7</accession>
    <name>A0A2T4BWR7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_58119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWR7"/>
    <dbReference type="STRING" id="983965.A0A2T4BWR7"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000207">
        <property type="entry name" value="Glycoside hydrolase family 128 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015693999" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="26"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="319" mass="34945" checksum="AFF0E39EE8626FDB" modified="2018-07-18" version="1">MATLTISSLLLLISLSNASSSDKRGLVFTPNNDYPQDNQVWVQSGSDLTWYYNYQSQPSPAYTSLSQEQFEFVPMMWGVTDNLNDTTFLDQVTTLIKQGTNITHVLGFNEPDGSTGTGGSAIEPRDAAQAWVANFEPLGKQGVKLGLPACTGGPGGLPWLKQFLANCSDIVSEGSKNKRNCTWDFLPVHWYDNFAGLASHIGERRATWPDADIWVTEYAFANQDLQTTQQFFNQTLDYFGKLDYIGRYTYFGAFRSKASNVGPNASFLNNAGKLTDIGSWYLGFGATNIKPTSAAARELVSGWVIAGAVLMIACMNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXE5</accession>
    <name>A0A2T4BXE5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_125512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXE5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17051" checksum="B16E2005F57CB0AF" modified="2018-07-18" version="1">MPFGNKTPGGPFESRLTVDGNPKFSVALPSCKLLLQKKRTHRFVLCTRMNSSLFSSHFQPGNRWRLSVLVSVHAACRAHPSSLPHHLSGAGEAPRSKFPSSCRELSSASHITSYCAARLGGRLAFDPSFDSPALPPHLPQSQSLTPFPACPQSASMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXL2</accession>
    <name>A0A2T4BXL2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1057454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXL2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="17933" checksum="FC4CF9097073E88E" modified="2018-07-18" version="1">MELSSVKVTNRDVLGIRSDCRLISDGVVVLFLFESARRRMPSSIHHLPPSPVGLSTGSSWSLMSMYLHRSSADLLWSVLSPPVACIIIPIGFLRSWPLREKEEEGVGRRVETRVALWERGNFTSQSTASPPFRQAPFDGILSCSIKAGTAWNLLPLDPPGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY45</accession>
    <name>A0A2T4BY45_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_6458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="278" mass="30288" checksum="24A8C01089ED11F8" modified="2018-07-18" version="1">MLAIGPPAMPLRSADGSQPDASSLQHLSYATYRARTAADIAYAAYGDLVKIDSALCKKLASEAALREPVQRRADQKLNIERRSNVEALLAHMTGQPAHNPCKNCRKGHGPWSQCIVYEGQMCGSCTNCWFNASGSRCTFHENNHPMPQALFTNSAAAASGASILASLSQVQAPPPPPSSNPSLSVDVHHWGLSDSTKRLITQTITDVATFSKRERFLARIEAAAKELGMRIAEYEDFMRTPEGVAEQNAAIDRERAQTAYTQTTEVCMPDAPWDGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY70</accession>
    <name>A0A2T4BY70_TRILO</name>
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        <submittedName>
            <fullName evidence="3">YjeF N-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1393376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BY70"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="125"/>
            <end position="385"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="417" mass="45701" checksum="257C873CCBC090B2" modified="2018-07-18" version="1">MSQFIGLHMRVVLRDPAGHLLTGTVSDVQAGISLTLTNVFLTATREWIPHIRIDAANIADLSEVRCDGPDTNLPVPKTTLRYQASRRSSPTTGHRSTDYEQQQQQPGLYLVPSNRRVETISTLQMLNIENIAANEMGFSEALMAENAGRGIAEVAVTALSDPAMKVRFEMVVAGASSNASLRTSTIVILAGNNKSGTRALAAGRHLRNKNFDVVVCLVGIERERDLLEDLRRQIQLYRNFGGKVLSKNDFFEYLRKGTGSASGLPISLIIDALLGLTMSFEELRVGDQASVYELMEWANRNEAFVLAVDVPSGIDPTSGKVAIIDGGHLFVKPRYVVAIGAPKKGLLEAVTPPPHDDSGLSSDIGHEDVWRLFIADLGLGSSIWRKSGTKIRRGIDFDGKWVLEMKYRGLDESEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYS9</accession>
    <name>A0A2T4BYS9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1424267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYS9"/>
    <dbReference type="OrthoDB" id="4900578at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17695" checksum="4B640C26F5292D50" modified="2018-07-18" version="1">MALPIPLSVKAGRKTGRNGAARDEPHLTCRTHRQDEKEQESDAHLSSRSLPLKAALPRLKDKLRSFNPLKRRAKGAEGRSIPAAAYGYLLPTNADECSTPIDASLLRQKLLRLQRLQEQPPSRKDAGDTEEREFVSADEGSASSPKRPFSRIRRWCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZW3</accession>
    <name>A0A2T4BZW3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1393094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BZW3"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="18454" checksum="BFA0F681FC83830A" modified="2018-07-18" version="1">MEYQPRGACYSCGSTGHQARDCPSKGPAKCYNCGGEGHISRDCTEPTKDNKSCYKCGQPGHISRDCMQGGGPAAGGQSTECYKCGEKGHIARSCPKSGGGFGNNSYGNSGYGGGAGKTCYSCGGYGHMSRECVNGMKCYNCGESGHYSRDCPKESAGGEKICYKCQQGGHVQAQCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0E7</accession>
    <name>A0A2T4C0E7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1402544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0E7"/>
    <dbReference type="STRING" id="983965.A0A2T4C0E7"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19122">
        <property type="entry name" value="AKR_AKR3E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000025">
        <property type="entry name" value="NADP(+)-dependent glycerol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="123"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="424" mass="47801" checksum="EFA79EB945A27B6C" modified="2018-07-18" version="1">MRYLDSSVVGYLDGDTAATPSESLYKETAISRVALHEKTRYVVSLVEADTSLITLIRFGAPNRREQRSHFIPVIYPTQNITIFPQPRARIPITSETRHKPRNRSDIMATKTFTLNTGAKIPAVGFGTFANEGAKGETYAAVTKALDVGYRHLDCAWFYHNEDEVGDAIRDFLARRPDVKREDLFICTKVWNHLHEPEDVKWSAKNSCENLKVDYIDLFLVHWPIAAEKNSDRSVKLGPDGKYVINQALTENPEPTWRAMEELVESGLVKAIGVSNWTIPGLKKLLQIAKIKPAVNQIEIHPFLPNEELVAFCFENGILPEAYSPLGSQNQVPSTGERVRDDPTLNAVAERSGYSLAQILLAWGLKRGYVVLPKSSTPSRIESNFNIPELSDEDFEAIQQVAKGRHTRFVNMKDTFGYNVWPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Q9</accession>
    <name>A0A2T4C0Q9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative subunit of Golgi mannosyltransferase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1439686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0Q9"/>
    <dbReference type="STRING" id="983965.A0A2T4C0Q9"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="404" mass="45761" checksum="91FC272A8AC3E778" modified="2018-07-18" version="1">MFVGGVRSSKLSALLAGAIIFIIVFAGLVYNQLDSTELPNRTQSNAGTVPSGSKAAPPSDPVKPAEPVKPVKPVEPSKSDIPDSTFRDVWFDIHKPSITPNSSFYQPFGAFKYDLKHGVHFPEPLGHDLCIIDLDNRPFDAPNQIFGPNVMSWETDAEKVHGLSVGVLNHWLYAKIHGYKYYFVAIEKPEDRRASWKKAPVISTILKEHKTCLYLDSDAIFQNLDLPFEWLLNFWNLDPRNNSLALAVDPNREYNKDKFGKLMLNTGFIVAQNNPKTYEIMDAWAGCPEEDGKHPECVEFRTNSPGRPTDQGGFGTFIRYDYPDDIRQLPCTDANGFPNSDSECEGRFIRHLWTGKDSWIKVFVGQQVPGRYLELFHKEFLDEKSKFYITEKDLMAKSASKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0R1</accession>
    <name>A0A2T4C0R1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mfs allantoate protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1423230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1350" mass="155743" checksum="8053B05FF336FAA7" modified="2018-07-18" version="1">MIQGYSECQVYGLYKGYKRRNAELDALEADPPAYLKTSKVPLANQTFEDVQDPETLRTLHSHLFKRYVLTGKVIDARKLHHTHFYSLNIDFGHQAYLDKLSSNRHTILRSLERLERRTADVLYQKEQWFAWVREAQEEEEANREKEQKKIKQEAALFKRHREKLQARLEKARREEEQKSQDAYLEAAFRERMAMSADEWDNDETWDPIKDTGHDKRNQYIDLIKHFLWMDVDDADENDQDPPAETRPAAAEAAPAPEAPAEAPAAEDGQKPSKRGKKKAKAKANAANSSDSGHLSGASAADRGQSKLMAMQESNPRSLTADQHVPDKNNIETEQEMRKRLSQGVDKKMDNISGFQLVGSLENPYETHTRTAPMTNDEIESVIKDIRVIKLLLFCRLLLAQASMLPAALRAGSVEEFLDDAELVDSDLRDICLKLEDPSLQEIRDACADFARGDDAEDDVDLDSEDSDSEDDEDTIRDMMTDHNRYAHLDSGEWLMDKIADRQYKALPKKEKEKTTRSQPQKTRVTVCGKSVWNHASEKAMSRDGWLHFSIIAKDCDLKHAIELCRNWAEFTDLNLLTLWQYFPASNWTSWASNRLIQQLQELQFFPYFVDLDAERHTRHVQVGGRGKVRRQHDIYEGRNIIVGHMKRGDPVTRRFLQYLTMRTGELLVLVRDGKTGRVITAPPNEHLWTYRSKSGIGRASKNEWQNVLEVGPAYFYMTDILREWRFSFDDYYDVFIWSFVPGQSPLDMYNVVISELRTAWRITHPREVYSHMEPLLRTLTREKDTMCNPGEQVESLWDVVAGDAVEFCLFDVKDGKVNCRTTRELASSPYLFYNKANVAEDEVLFPDELVSPRDKVPFREIRNAINRLEAPMLPSEARHLEKGLQAICEGNDPSSVMDKATDRDEDTIWALPALWETGLRQVLEGTLSAEQRELLRKTGLDTINESQSLADRLESAEGLEIMERDRSFNFKEAFHEGDLEPGSNEKYSLVQELITSMLKTPHAGKPDWVFYIAEIMSWLKIRADYDEYSNDPRAPWPHSFVVQDMVQAFVTMAMFFPESETAANVMKLFDQEKVGKVRNSAIFDPRERSKTLPDRRSRTSYKFRDPEFWTPWKDLGKTKRYFADVYPLDWSIAVRPIVAKLYRAGIIAPAYLQNDPEIVPGVATAMTEPHRPDKLDLFICYEDPYKRFAPQFPPNFAGPNKWPKVLPHAEAFASKHQNARFALLRLWSAPHFYPLMVGLQNRQGNSFLDSVGRPFEWKFVNKDMPGSEFSIHLTVSSRLDVLKQQFGDRVVSRGDLILVMGEDAVDLMKYCTAVTFALQTKPWLREVDLWKSYINVGLDLLQELDPYWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0T7</accession>
    <name>A0A2T4C0T7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1358064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0T7"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="271" mass="29292" checksum="10BCFC52122D10B8" modified="2018-07-18" version="1">MPSYVITGASRGLGFEFLRQLSNYSNNIVIGLVRNKPATDEAVAQTLAGRSNIHILQVDITDYEALKHAVAETAKITGGTLDYLIANAAYISEFDAYDPIGVLGETPQALEHDLLKSFKVNVIANVHLFNLYMPLILGGSAKKVVALSTGMADLDSMNKHELHVAPGYAISKAAMNVAVGKFHAQYKKEGVLFMSISPGVVDTGHYKNATPEQMEKVGGMFQKFVLNNPDFKGPAKAEDAVRDVIAVWEKASIEDGSGGAYVSHHGNKKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C122</accession>
    <name>A0A2T4C122_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1379362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C122"/>
    <dbReference type="STRING" id="983965.A0A2T4C122"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="168"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB75270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="570" mass="61051" checksum="5E132050C3C66D1F" modified="2018-07-18" version="1">MTMARTNNDGEMAFDGEDGRLLAHDFGFNSNRASSYDARDSPRTDSPASTDLGLIPSVLKAPRSEFEHEVKTPRTPGRVQFDLTPRILNFSDAPLGRLSTSSSLSSGDRFDFDDHDASAASGYDSHRVPLLTDLEAPSVTVAREWDDAGDGDEEHANAAEAELRRPKSGLQSAFMNMANSIIGAGIIGQPYAMRQAGLLAGTLLLLALTVVVDWTICLIVINSKLSGTSSFQGTVQHCFGRPGLIAISVAQWVFAFGGMVAFGVIVGDTIPHVLTAIWTDLPTVPVLGLLTDRRVAIAVFCMGISYPLTLYRDIAKLAKASTLALIGMLVIVVTVLVQGVLVPSADRGSFSAPLLTVNGGIFQAIGVISFAFVCHHNSLLIYGSLKTPTIDNFSRVTHYSTGVSMLACLIMALGGFLTFGDKTLGNVLNNFSSDNSMVNVARLCFGLNMLTTLPLEAFVCREVMITYFYPDEPFELRRHLILSTALVAGATTLSMLTCDLGIVFELVGATSAVAMAYILPPMCYIKLTTRSWRTYVAAAIVVFGVAVMVISVIQAIDKMINGSETAAQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C187</accession>
    <name>A0A2T4C187_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1335466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C187"/>
    <dbReference type="STRING" id="983965.A0A2T4C187"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF140">
        <property type="entry name" value="FMN HYDROXY ACID DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015488323" evidence="6">
        <location>
            <begin position="17"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="383" mass="42094" checksum="B22599DF6578B683" modified="2018-07-18" version="1">MRCHLIAALLASEALAARPFLNEPDTGIDDVLADLPKGTLPDLSDIVGLPDFDWAARHYLPVKNYTYYRNGAAGEWSYRNNLEVFHRYRLRPRVMVDITKIESTLPTTILGHNFSAPIFISPCARGTYGHPDGELNFVKGAAAGNILYMPALFASYTIEEIAAAKAEGQVVFQQLYLSSNDTETQDLLDRSKKAGASAIIFTVDSAADGNRHRAARYGVGSADSEYTYITWEYYRKITRMTDLPVILKGIMTVEDAKLAVKHKVPAIVLSNHGGRQLDGTPSSLEVALEIHQRAPEVFKKLEVYADGGVRYGADVLKLLSLGVKAVGLGRPFMFANVFGTKGIEKAIDIIKHEIAIDAANLGVGDLKKIDSSYVQWTPDNWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1D3</accession>
    <name>A0A2T4C1D3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1423433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1D3"/>
    <dbReference type="STRING" id="983965.A0A2T4C1D3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015582132" evidence="1">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="15067" checksum="BD61096ED61EE821" modified="2018-07-18" version="1" fragment="single">MMRIISIILLLVATTTDQALAKPAHGPRVDLGYAVYEGLYNATLDLNIWKSIRYAAPPVGNLRWQAPQEPPKATTPDRLVSSVDQPPWCPQSGAYGVPSVYGFNSALGNEDCLYLNVYAPPHAENLPVFVWIHGGGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1H5</accession>
    <name>A0A2T4C1H5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1471128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1H5"/>
    <dbReference type="OrthoDB" id="10037289at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="457" mass="51275" checksum="E87B65C52B7223F9" modified="2018-07-18" version="1">MKRSIRDTDDGSSAQKPPAKRAATTKRASPRKKTAAQVTESPEPVEIAGPAPADSPSPSSGVPNTRRVPVGPNGEFFIPQTFPRELDKMVVSKRWVQIDGDPNHEFTLGNRRWWELNSPWLEANKKSIGLTAKHWKMRDEAFAKGEPRGDDEGDNPDDFVCISPPALEASSSEDDGDEDQDDDEENDDEDEEEERHAEAKAGKEKAREEKCERHKAVGKLAALHPEHKWVSSMRGNERHKWWISELLKRDQDDFLMHIYNDFTWYGTIEVLENLFVNFEKVLKRKTHTSMELWFELEGLALVLNSGCVEFQMCDDADRCGKILELVGYMTITVIGSLQKNNLFAKDSQIPNIGIMLALVLSYAHSMGTDYGWEDQVGWTPYVVKQATIAQITLAGPKRFDETLEGINELGAGKTAASQAKWSKGTFPSKLAAYGSRGGNQFDITTFSAAERKKYSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C261</accession>
    <name>A0A2T4C261_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1422740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C261"/>
    <dbReference type="STRING" id="983965.A0A2T4C261"/>
    <dbReference type="OrthoDB" id="2562743at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="455" mass="50508" checksum="B960A99B221E0AA3" modified="2018-07-18" version="1">MPTHRHNYPPSDPVAERKVRQAIEEAASRNTQLLGELEATAHAPGLFNNNQIKIEHVDKRMADLEPEVQEAIAAANQQLKQHKSYRDSVAKKFVYTVLKKKGAFDEKAMREEKAYHEVLEKRHKVEAKLDELKADKAALVVEMKELEELLGRHGAAHKAIDALYSNIFDGPTAGFADEDEQEEAHKLAKLALQERTEALKAAVRGVRAAQAVKVAIERSLFEKQRASFENHSDIFSQRGVQTILKRCVAYISRGLDLSDEAVGAIQATPGPDLTQAKTTLDGLFITARAVAQERYYSRSANAELIERLGATLTKALDAQKKYVEAMKKVSESRRESIRRAARALEDERRALQQIRQSAFETTVGFGAAAPAYHECCDRAPGFEHDSHQQSASIAEPVVIELPEDAEPPPDYMYHEDGIARPKQMEAEPGSNPQHRVSQLGGVVTQANSQGLPEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C299</accession>
    <name>A0A2T4C299_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1334426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C299"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="481" mass="53804" checksum="0F8FA9161DDD3DB7" modified="2018-07-18" version="1">MTRLGTWRATYLVALSCVGSFLFAYDTGIVGGVLTLQSFQRDMGFSEREKENVASLSASLLQAGAFFSCLFVWPFTARYGRRWALAVASLIFNIGAILQLFYQHGIATWYAGRTISGIGAGVATVIIPMYSAEMAPKEIRGQLGSLFQFFFTLGVSASYWVDYGAAQHMAPSTTRQWRVPVALQLVPGGILGLGMLLTKESTRWLAQRDRHEEALESLIWVRGGDRLEVRMEFREIVAGIEEEERLTAGFSWKEYWLPANRHRIFLAVTLQIGAQLTGNTSLAYFSPQVFQAVGAGQNALLLSGFFGVCKVVSCAFFLLFLVERIGRRWSLLAGSFLMGAYMFIISVLTQRYPPRVDGGRLTPPAIASLTMIFLEAMTFNISWGPIPWLYMSEIFPTRVREGGIAVGAATQWLFGFTLSQVTPAAVNNLGWKAFLMFCCFNWALVLYTWFFIKETKGLSLEEMDICESENCRSFIKSTCHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Y3</accession>
    <name>A0A2T4C2Y3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-classical export protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1439539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6013" checksum="A741FC7701883CDB" modified="2018-07-18" version="1">MAAPTYIISRVADPIFAVLIGLSAAATRINREEKAKGKTTNETIEAGLRRIGLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3N5</accession>
    <name>A0A2T4C3N5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Asparagine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1430935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="7">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="413"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="551" mass="60248" checksum="BD29239C8C1B1BD3" modified="2018-07-18" version="1">MCGIHGAVTANGCPHRLSPGLERRLRNRGPDHLGTIEAQLSPDEGSLRVALTSTVLSLRGDHLAKQPLVDAESGSVLCWNGEAWKLSGKRVEGNDGEAVLSLLAAAASRDPGSEDSVLDALRSIDGPFAFIFLDRKAKRLYYGRDRLGRRSLLLKRGDEFLLSSIAEAPAEGWAEVEADGCYTVQLDATDSPAQLVPIRHDWDQNKDLVSSIGIFNASIPAPTATTAPLTGQSPSVEQLRHHLTESLQLRVLNVPRPPMAETSDARVAILFSGGLDCTVLARMASDMIPPEQAIDLINVAFENPRVAAQNAKLSTDELYELCPDRITGRKSFAELSTVCPDRRWRFVTVNVPYEETCAHRAEVIELIYPHNTEMDLSIACALYFAARGQGTGQLATGLEAAEPYSTTARVLLSGLGADELFGGYVRHATAFTRSGYPGLIDELKLDVGRLGKRNLGRDDRVMAHWSREVRFPYLDESLVKWAIELPAWEKCDFGNQGNGCDLEPEKRVLRLLAESLGMRSVAMEKKRAIQFGARTAKMESGKVKGTTLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Z3</accession>
    <name>A0A2T4C3Z3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1249356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Z3"/>
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    </dbReference>
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            <begin position="31"/>
            <end position="50"/>
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            <begin position="25"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="PTB76281.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="464" mass="52542" checksum="235653DCC902A114" modified="2018-07-18" version="1">MDFNATLDPVAVDDEQLSHHQINTLVLVERIGGTLSLISVMLIFVTYWLVRRVRNVQNTFIVFASVSNIGASIGSIIAYDGMEAGQRTALCQAQSFMFEMFMQSDPWWSLAMAVNVFLVFYFHTNPDSFRKHWWIYCLICYGGPFVIALTLLLVRSPRGLVYGGATIWCWVDKEWDYIRIYTYYMLIWICIVGSILCYFLVGWHVFRMRNRLRSFSTSRNREKDRGVDQGGEAAQNGFYGTVTIEVQVTHTLADSVPPEPQPAYIPRNTRHVSFDSPEPEIQPSSDNQYYSTVTTAPQEAPPPPPLFQRFMTTVTTITSQFRVGDPIKRAYLRTSFLFALSVLVTWIPSSLNRIHGWLDGGSPYEFHVATAAVLPLQGLWNGIIFFVTSWRSIKAWINETFKASAAVIERHKADELGINERTAGPLNPLNRCDSFMDDGDSATIGSDVELRRVPNSGTKTAHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C497</accession>
    <name>A0A2T4C497_TRILO</name>
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        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_54360</name>
    </gene>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB76381.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="344" mass="37992" checksum="C0E0D2B73B6BA852" modified="2018-07-18" version="1">MSIKYAKDQPAGFTNRIERVAIVGAGGQVGKHIAEELLKTGKHTVTAITRIGSTSELPKGVKVAPIDYDDEDTIVDALRGQQFLFISLAVTAPKDAQARLMAAAGKAGVPWVMPNSYGADYANKALQADIMTQAGTESGVAAAEEAGLSWIYMSCSFWYEYSLSMGNAWYGFEIPERKVTFYDDGKTRINTSTWRQCGRAAAQLLSLKELPDDENDQSTTISQWRNKPLYISSFLVSQRDMLDSLNRVLGTTDADWQIEYEPSDVRYKRGLELFKTGNMLGFGMAMYSRAFYPNGDGNYEAKYGLANKALGLPEEDLDEATKLAVEMAEAGFAAKRFQEIAKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C565</accession>
    <name>A0A2T4C565_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">M440DRAFT_1318222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C565"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="74" mass="7451" checksum="C85187BB62DFB504" modified="2018-07-18" version="1" fragment="single">MPSRGASGGLASFRPAILGLGRVLGLCFTAVSAAPLSQAPDHHDTNTPVWVLAVSSMTLVLLGGAFAGLTIAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5I6</accession>
    <name>A0A2T4C5I6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1430585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C5I6"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="508" mass="56234" checksum="162F43B649F07CDC" modified="2018-07-18" version="1">MPAKREVEDTDGDTPEPQTKRAKMSSSKTRQHQHSGIDPTWGQKYVFSGSENATTIPEGEESEFEDDTDAMAYLMSVRQQAYSIPHLLVAPPVQIGPQLPPGFDREEDESEEEGEMKESFHAADASNAPDLNGFYEDGAYIGISEGWRGNDADQEDVPDDENPEAIQKAVDEAYFASILQQYHHLRKILHRKPPANATRRLSRSQATEAFSFGRSTITLWSRLLKTTDPHPVQVALMSKDTVLKILRVMMSGKFLQSGYSIPPRTSQWLWALLARLPAMGELNHAEISWIRDLGRRAVLLGRSLAEMAALREELADSGFGVNDNVDASSSDEEVVAESIEEGDEEGDGGVNDGDALPMPKVTMTEPPPAVARRRRNSSSPIPDAVDDENVIPAGGTDKAAEDVDEGEIGEAKKDSEDEDEDVAMDIASDSSADEGEISEQPDEATALEEAKHRLLARLAESENERRKEEERRDARMNMRATLTMILTVAGEFYGQRDLLEFREPFVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5J6</accession>
    <name>A0A2T4C5J6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_53279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5J6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5J6"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="126"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="302" mass="32369" checksum="0D670DEB47B424C3" modified="2018-07-18" version="1">MSSSSSSTPPSSLAHLLPPSWQTQVTAWLAEDTPSFDYAGFVVGDAPRTATLWAKSPGIIAGRPFFDQVFHQCGCAVEWHADECSPIDLRRDAGNKMKVATVTGPARGILLGERVALNALARCSGVATQSYNLVTKLRKAGYKGVLAGTRKTTPGFRLVEKYGMLAGGADAHRMDLSAMVMLKDNHVWSRGSITEAVAAAKSVAGFSVKIEVEVQSEAEADEAIEAGADVVMLDNFTGDGVKVAARSLKERWAGKRHFLLEVSGGLREDNVEPYVCNDVDIISTSSIHQGVPHVDFSLKINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C610</accession>
    <name>A0A2T4C610_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1401308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C610"/>
    <dbReference type="STRING" id="983965.A0A2T4C610"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="178"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="599" mass="67683" checksum="7F477BC89BE5463C" modified="2018-07-18" version="1">MASHLLLKAVASSTSPMIRRARLPSQFQRSRLRPALSLNCTVPARSSLIHHVRLQSTVAEPQKKKLRWYWKLLIALGATIGVTAGGVLVADRYYMGGILTRSLRAYATLAQVGLDYKMHSGKNPKQARIPIDELHDRNAKRVADMIKTNGGMFLKIGQAIAVQGAALPEAYQREFKDMFDDAAQESWSDVQAVIREEFGASVSEVFGDEVEREPRASASIAQVHYARLRDGREVAIKVQKRKLAQQASWDLWTFKVICDLIGRTTDIPIQGIGDYIMNNIMKETDFENEAANTMRISELVKSDPNLSARVYIPQVYTDLTTKRVLTSEWIHGAKLWDKDIITGQYNGSDEIPSGMGLKEVDVMTTVIDLFSSQMFKWGFVHCDPHPGNMFVRRLPSGKPQIVLIDHGLYVSLSDDLRRQYARFWKSLLTGDKKGLDEVSAAWGMKTSDAWADTFMSRDSKKPEPTDETPEERSERLIGEAAAFFGEDGLYPRELMFLERNLALVQGSNRFYDSPVNRLGMIGRSAMLNLRDDSKVTFSQALGSQWAMFVLDAVFYLSRWRQYMGWGKGFEDELKEAEERMAQDMKGSMSGLWEVDKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C621</accession>
    <name>A0A2T4C621_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1456610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C621"/>
    <dbReference type="STRING" id="983965.A0A2T4C621"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="311"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="757"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="920"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="920"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="955" mass="107697" checksum="D6E460857C8DB7F3" modified="2018-07-18" version="1">MVQEKDMSGKQEESLFVEGTLGKEMRPTPEITTGSPSADLANPEDDVEHNVFSLLSHLTAGDVDLIDEILSSDYEVSEAEAGFAEDNCSDEVQYSGDDNQSDPEDGPVDGDVSDQEDDSDFEIESDSSSSGGEEEQDKPAKRARKTDAKTPRRKPAMNAREFVARLHEEEDRQYAKKMEQEEKRNASGFSPPKRKPTETNKVPFKALKMGYDGTPSKAGGIASTSNDGPLVPMEPIKATTHAQQFAQIKAQIPKNSDTRRKNSQEKDLRQAAKLFGYKRVEADNGRWKLKGMETALEPYQLTAVAWMVKRELSRSKPFGGLLADSMGMGKTMMSLACIMGNQADTEHKKEYCNATLVVVPNKTFGKQWEDEARKHCKSPVKDKIFVYDRNDGQLMERCKKSFIVITTYHEIIFQFPRKSTISEAKKKSKDKSSFKRSVASLLGPIFKVKWYRIILDEAHVIKNPDSSKMYPYLRFTKCESTLDPRLFNSTFTHDGHVNAEFEALISLVMYRRTLKDEFLGYKIIDLPEKVEADLLVPLSSEEQCIVNAVKDFYEGKIALLESGELDQDEYEAAIGCLDLVDEVKVDEAEAEKSRPRKSSGKVSAFAMRIASQVRRRQAISHTFCIEKLLRYSLQPVELKALKDALQKVGPTKQTILEQIRNVSNTDGDILKDNYRLGTKTVLCPYEDCDKALYVGEDVCTLRGKIDSEDKKGDDSSRDRNNATVHLEDDRNGFLLCGLLSKGASVVPSTRLTATMAVVLTWLHDVPDDKILMFTQFKATAKVLGCMLRALEIGFVYYYGGLTLGQKRKALEAIKTNGDIKIMVSTLKAGGQCLNLTVANRVVIIDPWWNKTAEQQAFGRVTRIGQEKITHLVNIRVKEEFDEYVHERQIEKAEDVDYTLQDDGHTPRVVSELELQRAFEKKKKEKEDKKKRKDKKKKKRVEKAMKKKTKAAAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C686</accession>
    <name>A0A2T4C686_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">M440DRAFT_1376600</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C686"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="134"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="452"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="23">
        <location>
            <begin position="655"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="20">
        <location>
            <begin position="891"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="19">
        <location>
            <begin position="1060"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="19">
        <location>
            <begin position="1250"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PTB77065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1541" mass="172792" checksum="EF4F1BBFF380B1B1" modified="2018-07-18" version="1">MDEANASPPTHGGEAPMKLPVMIPERPENPAEESCENSQVTINTEDSELVEPEAGTDDVDQSNEASCAPKAPVAKKRKQNLAFEDWLQKNQREITTASQEDLDRHIDKISVARLVQVGIDHKIIASPREYQVDLYERAKQENTIVVLDTGSGKTLIAALLMRHMLQKELRYRADGHKHQYAFFLVEKVALCFQQHAVLTCNLEFPIGKFYGEMTGIARTQEYWDKQFAEHMAFVCTAQILLDILACGFISMSQINLIVFDEAHHAKKSHPYARIIKEHYLRTRNERPRILGMTASPVDALTRDVRYAAAELESMLCSKIATITDDAMMASQAHRRQVEVKELYDRLEDPENSKTRLWGIISQHVRGNPQFKGHLEFAANASSTLGTWCADRYWKLLTTDAEMIKLEARTGRDSFDVDVVAGDNAMAAVRRAREEIRDFNLGPIVRGSPELSSKVKLLHEVLEDAFCRHQAKRCIVFVQARATAFILADLFKQPRMLIPGMTAGYMIGSQSTTSSAAYMSYREQIVSLQKFRYGETNCLFATSVAEEGIDVPECDVIVRFDIYSSAIQYIQSKGRARQKSSLYISMIEQGNLDHMRKLRRAVRDAHALRQFCSALPEDRKVQDFVISPELLVAHEQATQKTFVIAETGAQLTFITSLDVLAKFASSFPNEAEDGIMPLEYIVNTVGKKFIARVVLPEGSPIKTITGEAQRSKQLARCSAAFEACVRLIQKKYINENLQPAFAKKLPEMRNARLALSLDKKSEYEMRIKPDFWSSCLGPEPPSSLYQTVISLDQPDALGRASRPLILLTRQPLPDIPSAPLYFGGGRSSNVYLANSQTSFEVPPHRIEALASFTLSLFADVFSKEYEAKSHEMPYFIAPGTALLNGDVEIDWEAVQFVYENERLEWEHAPEEFFKGKLAVDPWDGSRKYILHGVNADLKPSDPTPEGVPQPKSLAYKRVKHNIKEYSNSLSFNSRKRMNWTDDQPVVNAELLPIRRNFLDEFFVDDEGDRSCYIILEPLRVSPIPVDAVAMALVLPVVMYRVDSVLIAQEACSLVGLTIRSDLALEAVTKDSFNTEEHGEHQVDFQPGMGRNYERLEFLGDTFLKMATTISVFTLFPNADEFEYHVTRMIMLCNQNLFKHAVEKGMPAYIRTQAFDRRTWYPSSMTLKRGKAAKTESKHCLSHKSIADVSEALIGAAYMSSPTGDMDMAVKAVAAMVCSINHTMTSYKDYFATFTAPKWYSQQATAAQRLTVDKVAEITGYRFKSAPLARSAFVHPSYVFENGIRDYQRLEFLGDGLLDMAIVDFLFKRFPEADPKWLTEHKTAMVSNQFLGCLCVKLGLHKHILLATSSLLGDIGRYAAQLEQAEEMARQNSQAEPESIPQDFWVEVPQPPKVLADVVEALVGAMFVDSGYSFSVVLDFFTRFIQPYFEDMALYSSFASNHPVTTLAHKLEGDFHCTQWKLHVASVPAPVEAGIAVVSSSEILCALMIHGTVIAHATSSKSGTAAKVAVAKLALEKLALVQDVDQFRREMQCDCGGSATGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6H0</accession>
    <name>A0A2T4C6H0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1420978</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6H0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6H0"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="36"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="381"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="74"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB77166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="500" mass="53595" checksum="C41527EFD6B23AA1" modified="2018-07-18" version="1">MLVSRLIPRSAVRTLPTRQLTLSRWSRGFASASEEKDLIIIGGGVAGYVAAIKAGQEGMKVACIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHQILHDSKHRGIEVGEVKLNLENFMKAKETAVTGLTKGVEFLLKKNGAEYIKGTGSFINENEIKVNLNDGGETVLRGKNILIATGSEATPFPGLQIDEKRVITSTGAIALQKVPETMTVIGGGIIGLEMASVWSRLGTKVTVVEFLGQIGGPGMDTEISKATQRILKKQGIEFKLNTKVVSGDTNGELVKLDIDAAKGGKPESIDSEVVLVAIGRRPYTQGLGLENIGLELDERGRVIIDSEYRTKIPHIRCIGDVTFGPMLAHKAEEEAVAVVEYIAKGHGHVNYGCIPSVMYTHPEVAWVGQSEQDLKSQNIPYKIGTFPFSANSRAKTNLDTDGLVKILADPETDRLLGAHIVGPGAGEMIAEATLALEYGASSEDIARTCHAHPTLSEAFKEAAMATHAKAIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6J0</accession>
    <name>A0A2T4C6J0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1400098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6J0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6J0"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35888" checksum="2A32D237C9F167D4" modified="2018-07-18" version="1">MQPSALLDLRFYRGVPEYRDVLAVVSSTGTLAVFEFDPLRDASAPLQQLATSRCEDLDDDVLFLQCNWHPVARRVLGITTSTGLARLLLLDDEWKIAKSVDVDIQNSLEAWCIAFAPVDPSSDAADQPISVYCGGDDSMLRYTTCHWVRDGDGNDPSSTLDVPFGPVTIKGQHDAGVTAILPLPLSTGDHGRLVATGSYDDHLRVFAIHDLHQSHGLKRVQQLAVANLGGGVWRLNLVDIQNTEGLTKIRILASCMYAGARLVEIVTDSSGRDCTCVVLARFEEHKSMNYASDVVPSPPAEDGRTRIVSTSFYDKLLCLWEYEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6R5</accession>
    <name>A0A2T4C6R5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1330387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6R5"/>
    <dbReference type="OrthoDB" id="2122015at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="54" mass="6287" checksum="7992979EA9F21D09" modified="2018-07-18" version="1">MSQASFPNLRRLFIEARTEDEERNISRKAFYHAVLFMGSVAVFSLIAQRLNARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Z9</accession>
    <name>A0A2T4C6Z9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1400257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Z9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Z9"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="854"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121698" checksum="E616261C1B89D1DB" modified="2018-07-18" version="1">MSENMTPEPDEKEPNVDLRITFDDASHPADVAGRSNAFDRDQPRSAFRKRSMSRGSASSRRERATSPYSGVPIEYRTLSIHVSESRNVDSDNLADAKAHRKENKEEYFSNLTFHELPVSQLCQQLNVSQDEGLSGTAADLRLQRDGRNTLPHPKTNYLRKILLYVFGGFCSVLWVGVVIFFICWRPLSNPPSPTNLALAILVLIVILLQAGFSAFQDWSTSRTMKSITDLLPSEALVLRDGQLMKLRATELVSGDVVHLNIGNKVPADMRIISHSGDLRFDRAVLTGESDEIEASVDQTDENFLESRNIALMGTLVVNGSGVGVVVLTGPRSVMGRIATATASAKERPTLIQREITRFVYIIVALTLVLALLILFTWLGWLRRDHPAYMNVVAMLNNVMGCVVAFIPEGMPVAVALTLMMVARRMKATNVLPKGLSTVETLGCVNVVCSDKTGTLTQNQMHINSVAFVDEPVAIQDIYNSLSGDDVDTGVKKLHQAATLCNDATFEPSTLHLPVASRTIQGNATDGAVLRFSAAAPSSTEEVEKPIKVFQIPFNSKNKWMLTMYKNASECPGLNEFQVFVKGAPDVLLPTCSAYWSRKSNCVMPLDAKAKAAFKEYQDKLSKNAERVIVLCMKNMTVQEAMGTNAFSDEVTSRATEDLMVVGILGITDPPRPETLDTVKECRRAGTRFFMVTGDYGLTAAAIARNVGIFTCERDPDNIAVVQANHDADAAKKLNSARVAGECRSLLLEGHSLGSLSDDDWSIVCEYQEIVFARTTPEQKLRIVEEFRKRDNVVAVTGDGVNDAPALRAADVGVAIVSGSDVAIEAADLVLLDRFDSIIDAIRLGRLVFQNLQKVIAYLLPAGSWSEIWPVILNVFFGVPLPLSSFLMIMICVFTDLFLSLSLIMEKEEFDLLSLPPRNHKKDHLINFKIYGQAYLFTGTAETICAHSMFFLYMWKKAGIPVHQLFFLFEGYSEGFHGYTQDQLNHFNYTGQCVYFVTLVILQWGNILSVRNRRLSIIQADPFTKKRRNPWLLLGMVISLAIAVFVTEVPGIHSLFLTAPVPIEFWLIPVPLALGILMLDEVRKLLVRLFPKGPVAKVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7D6</accession>
    <name>A0A2T4C7D6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1212932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7D6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="161" mass="17399" checksum="DB808A3742F9750A" modified="2018-07-18" version="1">MLRSSHTACKRRQCEPGVWQRLTTGELAGLIHPTAAAGCSWPMQCRQLSPTGVHPQRYDNSRALTDHLGDTTSIGARRVIGRGALQAACHKSPGTTIPKPNAAASRRGRSNGLKEEAPVGSWVGGRRREALSCGTPSCMPIRSCKREQIQMKIAMQSCINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7H3</accession>
    <name>A0A2T4C7H3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1400402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7H3"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015604487" description="VanZ-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ-like" evidence="4">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="203" mass="22877" checksum="7A9642DE7331E5DA" modified="2018-07-18" version="1">MRIRLPFAGVFLLLLLLAAYAGLSSLQLGAYINDKVLHFLTFFLLTIVFYWVVDTNRRRTLHMTLVVCTLVLGIGSEFVQSFLPNDRDFDLYDIVANIIGSLLGLGLCAWYHKRMLERKRQRKHYDAVPGDDAEDVELGQGQESGITDGPARGRTLEEEVDNWDENAEDNWDDDNVSVPDTPSPAVAKESDTADAREAKKRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7V2</accession>
    <name>A0A2T4C7V2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1353913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7V2"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="89" mass="9465" checksum="3D7AD0D602F0AD4F" modified="2018-07-18" version="1">MDFVKKAMGGSSGNQQESGIQGNQSTQGTAPAAPQQGGQKDDYVDKAFSMGSKKEGLNLDRNTQEKITDTGRGMYESATGNKVDPKYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Z3</accession>
    <name>A0A2T4C7Z3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_286538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Z3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="94" mass="10676" checksum="D5227C101ACDD4D6" modified="2018-07-18" version="1">MKKNMGVYTMPVCLLFLLDGHACSFPFFPCLLTFFVSLFSLFSANNESISHYPPRFRPPFLSFDSRLSLCFCRIMPLSRYQAPLRGGGVEQGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C874</accession>
    <name>A0A2T4C874_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_290294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C874"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="164" mass="18140" checksum="B325D9794C418535" modified="2018-07-18" version="1">MALDSGDTGSPHDGMGAWELHFPAVCISFILSPCLTGERVCSFSFCCDFTITTARGGGGGGARDVYTSSGPRRDRLERHHLGRQTVFGNGSWIYYECCIGGHMEPQDNVQRRQFLSKKLGFGPKCFAYNMGCHLHLTRRQPRKSPFLACNSDKCPVFQVQDHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8H8</accession>
    <name>A0A2T4C8H8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1330484</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8H8"/>
    <dbReference type="STRING" id="983965.A0A2T4C8H8"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000139">
        <property type="entry name" value="zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="285"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB77844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="401" mass="43441" checksum="85F0A97C33F6E964" modified="2018-07-18" version="1">MDRSGSPHMSEHSSYSAHSMSRAYPSPTAMQAPMQISSSMHNAMQMGGFADMSGMGNVPSMAMHHIHHQQPPPQQQQQHQQQQQPQQPQAPVKAYPCSTCGKGFARRSDLARHERIHTGVRPHVCDYPKCNKQFIQRSALTVHQRVHTGEKPHHCETCAKPFSDSSSLARHRRTHSGKRPYKCPYADCQKTFTRRTTLTRHQNHHTGTIEEAAAATAAALAATRVKNGSQARSDAGDHMSSHGSPLTTPSPSQHGMMSPALDLSGSNGIPRHAADFQYITQSGTLPPHLRVGSPASTTSAASYNTGIRPTSHPTGYGPPPTLEPNLEQHPAGSGSAGGSPHMSQVSWQSPQGHSPAHHGGSYVYPDPDGYPPNPSMSQMYYGAPQQMRRPQSAEPGMVHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8U6</accession>
    <name>A0A2T4C8U6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1462496</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8U6"/>
    <dbReference type="STRING" id="983965.A0A2T4C8U6"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB77980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="616" mass="67989" checksum="2E911B177C841DF4" modified="2018-07-18" version="1">MPILKEPWKKYKPFKPLHLPNRQWPDKVIEKAPRWLSSCLRDGNQSLPDPMNGEEKWRYFKMLCALGYKEIEVSFPSASQIDFDFTRRLIETPGAVPDDVFLQVLSPCRPDLIRRTVESVRGAKNAIIHIYLATSECFRQVVFGYTEEQTLELAVECTKLVRSLTKDDPTTAGTNWQFEFSPECFSDTDPDYALRVCRAVKAAWGPNGAAGDQIIFNLPATVELSTPNIYADLVEYFSTNIGDRESVCVSLHPHNDRGCSVAAAELGQMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVSPLIDFSDMNAVIEVVESCTKIPVHPRAPYGGSLVCAAFSGSHQDAIKKGFQNRARLGLSNEDPWAGMPYLPLDPQDIGRNYEAIIRVNSQSGKGGSAFILHSKLQLDLPRGLQVAFSKVVQRRAEELGRELLANEITDLFEETYFLRENPRLSLVDYSISPDRTQSPMPATNGRTQDTKSMIRIFEGVILLDGVEYKLRGRGNGPISSMAASLKEVGIDLDVHDYKEHAIGEGRGVKAASYLECKPTGSKQTVWGVGIHEDVVYSSLLAMLSAASNFLTSRPTSPLLKPVVNGPAQETPNIVSVLEEKVNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Y6</accession>
    <name>A0A2T4C8Y6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_17669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Y6"/>
    <dbReference type="STRING" id="983965.A0A2T4C8Y6"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16689" checksum="5C55A17BAA699803" modified="2018-07-18" version="1">MAANDTTSLPIIDFAKIVGPSISHSPEVIEESEKEKKKLFDAFVNLISTEHRVVEPEPKPDANGNIPDIVPARYAIAWFGHPNRDALVDPIDACCTPENPKKYAPVYAGQHVVERLAYLHKKGQNTTEWSDQMQRDKSQPTAAATPVAVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C938</accession>
    <name>A0A2T4C938_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1184551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C938"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17908" checksum="B1A0CE9894B54AA1" modified="2018-07-18" version="1">MEPAYEENFFFLTARGRHQHRRPWCLQPDGGPAGRQLQLVTFWKVHVVVRNHSCSKTTVEVEPFPQKSLARGLRGKSLLVPIALARAVDLSSSLKINSADCQVLSALPATTRPRYPRWRCANAWHALGQRRQPLGLVRSRFRALCPVLLHHVLLHHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9C3</accession>
    <name>A0A2T4C9C3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication factor C subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 41 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1437167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9C3"/>
    <dbReference type="STRING" id="983965.A0A2T4C9C3"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="64"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="381" mass="42231" checksum="024F6AEFACA38A3D" modified="2018-07-18" version="1">MASFFDLKARKAAAANGTSSQKNDKPADARVQPWVEKYRPKSLDDITAQDHTVTVLQRTLQASNLPHMLFYGPPGTGKTSTILALAKELYGPEMIKSRVLELNASDERGISIVRQKVKDFARMQLTNPPPHYKDKYPCPPFKIIILDEADSMTQDAQSALRRTMETYSKITRFCLICNYVTRIIDPLASRCSKFRFKSLDQGNAKKRLESIAEAEGVALEDGAVDTLIRCSEGDLRKAITYLQSAARLVGAKLPAKDGEGDDSMDVDKRPVTIKIVEDIAGVIPDATIGDLVKAMRPRTPGQTYQSISKVVEDLVADGWSAGQVVNQLYQDLVFDETIPDIQKNKIVLIFSEIDKRLVDGADEHLSILDLAMRIAAIMSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9G5</accession>
    <name>A0A2T4C9G5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1329338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9G5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9G5"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="647" mass="71041" checksum="CE61487A7D2B2109" modified="2018-07-18" version="1">MTPHRPELQGRRFWSGLSILSKRSYATSSFEADDEHSSGDDDMSLRDSFDSDMRPGVPAYAGHDARPTSRKEIWGWYMYGFAAETYVICGIASFIPILLETLARENGVLLSNPDKPCGSSDSKSEDDGQCVVYVLGIPINTASFAMYTFSASVLLQALLVVSISCAADHGNYRKRLLLAFAWLGGISVMAFIFINKTTYLLGAVLTIISNTSFGASFVLLNSFLPLLVRNHPEVMEAYVSESPDSVDGPFDSRHMADSTDDLDGASINSTSGLLRPDDRHHRYGLKRVATHEEITSKELQLSTHISSLGIGIGYSAALFVQCASIAILIAMKNTTWSQRVVLCIIGAWWSVFTIPAALWLRPRPGPALTIHGRKDGASWWVYLKYAWKSLFRTIQLARRLLDITLFLCGWFLLSDAIATTSSTAVLFAKTSLHMEPWALGMINVIATMAGIFGAFGWSWISRVFNLRPHQTILVCIGLFELIPIYGLLGYLPFIKRWGVVGLQQPWEMYPLAAVYGLVMGGLSSYCRSLFGELIPPGSEAAFYALYAITDKGSSVFGPAIVGAIIDKTGSIRPAFWFLGALVGLPAPLIYFINVERGKREGEKLAEAIEGFDPEEHAEEDETDEEAAHGLVADYEAAEGNGSASHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9J3</accession>
    <name>A0A2T4C9J3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1188536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C9J3"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1201"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1348"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1414"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1571"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1358"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1416"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1679"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1705"/>
            <end position="1717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1773" mass="200516" checksum="6B9B4AD6C4613F99" modified="2018-07-18" version="1">MAPDRLDESVSPMTRTPNAPSPTNAESQSRFQPPKSNDGMLAATPNSSEQQVGGRASPQSGGEYWNDGQRHHDPSPLGSGELKFDAQEPSPQEQRDIPAGLVSSTQETLQADGGRTIQFAQPDYHELPLQPPDSMPLEEPDTPTRSRTRFMSKIKAFAASGPQTPKSLNGPTFSSEFGSLSIPNSPTVSRVTTRAPEGLNGEQSDADADVETADEAAIPAAAKKNKRKSRRFKKHSMSGFPNPSRFPSDLDPISTYDRLLRRRASMPDTTQHDHAVSDGEIRDNPRRKPFRRGHSYMNTTMSPPGEDDMEEMENSAVVGRRNGHLRRITVFGGGGLSDGDALTPRRHFFKTDRASSYGAQKWKQVKSTLKLLRQKKEDRFDYYKSAELMAELRAGAPAVLMLASMIQRDEHGNKRIPVLLEQLKLRIKDSKPMPDDDKERHWIFTIELEYGSGPSRMNWCVIRTIRDIYNLHFRYKFALNNDKYMLGKDLGGRPKQPKFPYSAFPYLRGARNKGDESEEDDQASGRGEETGAEMTAAEDAGEGPHHHSRKKSRSNFLGMRRRSTGFTDGGELSVAEGNQGIDTQTRRQRYVEKQRRTLEKYLSEMIRWLMFRADSNRLCRFLELSALGVRLAAEGSYHGKEGYLHLQLSKGLDFRHVLTPAKVLSRQSRKWFLVRQSYIVCVESPENMNIYDVYLVDTKFSIVSKKKALKRFGSKNKDKNTEDDLNMEPSPEKHHTLKMRTSDRKVRLFSRYQSVMRQFEDSINEMLKQTVWYEKKRFDSFAPVRTGVFAQWLVDGRDYMWNVSRAINMARDVIYIHDWWLSPELYMRRPACISQKWRLDRLLQKKAREGVKVFVIIYRNVEAAVPIDSEYTKFSLLNLHPNIFVQRSPNQFKKNQFFFAHHEKICIVDHDVAFLGGIDLCFGRWDSPQHPIVDDKPTGFEPSELPKDAEHVQLFPGKDYSNPRVQDFFNLNEPYEEMYDRGKIPRMPWHDISMQVVGQPARDLTRHFVQRWNYLRRGRKPTRPLPFLLPPPDAKFEDLEALGLTGTCEVQMLRSASNWSLGINETEHSIQTAYVHLIEESDHFVYMENQFFITSTEAYGTRIINRIGDALVDRIIRAHQNNEDWRCVILIPLMPGFQNTVDEQEGTSVRLIIMCQYRSICRGEHSIFGRLRAAGIEPEDYISFYSLRQWGMMANDVLVTEQLYIHAKTIIVDDRVALIGSANINERSLLGSRDSEVAAIVRDTDMISSTMAGKPYKVGRFAHTLRMRLMREHLGLDVDEILEQEREEEEMNESAFERDMDAIYEEGATGAGDNSSISSYGAKSPILPPNNLRLPSFNHDIDLVKLETTSSSSASSVKGEEAETDPRVMNEGHQLDVSGYGPDHWKSAEEAGVDEGLDTVVVDGREMLLHSSKGLVESHHPRPHTAHQEHNDKSGIPPAPLPPVSRDGAERTDQLGLNPGAPAVPLPVLDDTSIGGPAAHVDPKTGHPTNEPFHPMAADILPAVINKDCMRDPLDSTFVDEVWNRAARNNTLLYRRVFRCMPDSKVGTWAEYREYMDYNAKFKAMMEGNSAGNENELRREASRQQDPTGDEAVLKHSDQPKIQLPEDEEGEETEKSAPGGSNGAEPALRPPPVDGSTDNQSSLEPPSPVYAAGEVPFPALDSTPSKPVSRSKSKDRRTNFSTLEKPTTKDTNGAPPPMPSGSAPVKRRRRATTKGSRRGLLIEEMPTRNEAEQLLGLIQGHLVEFPYDWLLTEEHNGNWGYQVDGVAPIAIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9S6</accession>
    <name>A0A2T4C9S6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1372747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9S6"/>
    <dbReference type="STRING" id="983965.A0A2T4C9S6"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="775" mass="85356" checksum="9D24F8E634EE8927" modified="2018-07-18" version="1">MAPRQPNPDDFISLLSSEDEAPLTRKRKYSEEDPVGGGGERASKGRAKRARASSASGPSLTGAKRIKAGKVDAIKSADIRESGFGAHGEEKKTGVFSPDTVFLPKAPPIYTINSISLQLPVFSPKREGTWLTRFTEWAQLLCSANRDSPGAGEITPAVIRTAYKQYIDIHSRLKSNKKRAARLVAQQFKDSSLLDLIRAFPPLHNEAAQLTAAVEEAFEESSEATSAGLDIRLDAPRPLALSPQIQFPSSAAAAPDVLTEQSDALYMIDVAPQLVQTTTVRERLLVSQPELLPASQPKHLRQTQQFSIEASMSLQFAVPSGAEALRQQRLYFPSAKDPSNMCLLCGGEGHVADNCTRSCRFCGGNGHWDHCCPSWALYCENCYRPGHLEATCWEVKERHWGVCAYCRSGDHHSSQNCMTLYRSFRPGPDTIKKVNSLPVSCAACGSQKHFHGDCPNFGVFGPRRDHRFHLDNMRQYLDPTSSAGPIVGTAACQKTPKAGGFRVSGRVLASSVDNVQYYSGSDDSDEGLHRHPLTRFHHVPIHHGRHHRLAYPAIEVARQGVVEAVREVAEVVPEAAKMIPLHKVVKLLKMSRFINRKMERVAKASKTAGAAAVNGRNEVAKLVKVDRDIKESQMYTASTLIKETSLAQVNRTVRQKGAKGDNDVVETVQMDAKEAMTGKLHKMVQLIRLIKQVKSAQVNKVIKMAQLSKTVKGNGAKDGDELAEEAHIVRLIRLGDLLQSRTPSTTRYQGLFRNQESNHRRLHQHYAAISRLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9W0</accession>
    <name>A0A2T4C9W0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_259243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9W0"/>
    <dbReference type="STRING" id="983965.A0A2T4C9W0"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="19630" checksum="12693E8F6B69167B" modified="2018-07-18" version="1">MFLTRNLSVLQSVFVNPNAAYLSSGPSASTPSPLNVGLENSRRFRALPAYAVLLSEGRPGFAGLFHSMTQLSRRLAVFLRESPYYDLLPDESGDIEEIFIIVLFRAKDKELNDELVAKINATRQLYVSGTSWKGEKAVRVAVSNWKVDIERDFKVVTKILDDVAEGREFDIEKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9W1</accession>
    <name>A0A2T4C9W1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1328393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9W1"/>
    <dbReference type="STRING" id="983965.A0A2T4C9W1"/>
    <dbReference type="OrthoDB" id="3550599at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
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        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="674" mass="73748" checksum="5B4880EDA279BCB0" modified="2018-07-18" version="1">MDCDETIRLGRTCSVWGCEDLIVAEALCSAHLALNCSPEASGPEPSAQRPLHKPKRTRRFALGRASARSAKNSTQQTACSPKQRDGALAHFRQELPTRPATHHLPSYGVSIPVPENPSVQTPADTAPSRQNRATIQDASASTVAVESIPPRPREPYFVLNPDVPSIDKNSSAFPRQQAARDLPERRHASKETNLEGNPAVVEGLVHAGLEFASTLRLSFAQTASATHDNVLSATPSVRAGDLNMEELPSITVANKASRKESNPVTSRRREASTINVVHESSRHTPLTGDIPLHLSPKKRKADVAGVQPSTQGPSHIQGNEAHSTSSASKRQTRSRSSAQSGDGTQTARSGKPSKAQSSKLGNDQGASHLRSSKRVRTSKGPTPASEIAQTRTNGRIENLGQGRGGYPDDNGRHGSIPISQQPQQPKPRETRSTDGRESRIPPPLPTPETDVTVEDQTTPAAGQSAVQELSTAKRHAFDSEAFDAMIYRQSSLHPPPGVPSQPATRPKTPTKVPSAGVQRQYLAVNPTIHMVHNRSDAWHKQKALEIQARGGRKAWFGKVIERRRWMRANERAKEEEQKAVKTSNKKPKRADPQPWSYDRIMDFGDVPEEELPEDVLQNPAWVKACAWHRENEAKRVLRDRAAKEAHREAWNYAESIMKEATLASEGSRGPSKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9X6</accession>
    <name>A0A2T4C9X6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1319345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="109" mass="12184" checksum="7B7E1A6A6FF4982F" modified="2018-07-18" version="1" fragment="single">LAPDEALFRRKDAPERYAEHDIYRAHEWELPNGGQGVLPKSDLLKAIHEYSSEFYGALNRGQGVLDSGRNLDERSMDETALLALGILLEEAGREVLGRRGHLVFTEGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA71</accession>
    <name>A0A2T4CA71_TRILO</name>
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        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">M440DRAFT_1390139</name>
    </gene>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CA71"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="9"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="335" mass="36483" checksum="2E0C68997F28F02D" modified="2018-07-18" version="1">MPSFTVYTGSENGHVKPSTTTKPDQLTGDQVFLRVTASGMCYTDVHYKHGPNALGHEGIGIVEETGPETTYLKKGDRVGWGYQTGSCGHCLECLQGQEIYCKERSIYGTGNTDQGSFSSHAVMREAFLHPIPDDISDEMAAPLMCAGATVFTALHDVDSNDTVGIMGVGGLGHIAIQFAAKLGCRVVVLSGSDRKKEDAFKLGAHRFIAMNGGDTEEQLGGWTISRLLVTTSAQPSWDKVLPLLSTRARIYPLSVSEDNFEIPYMPIIMSGLTIHGSLVATRAVHRKMIDFAAFHKIEPVIEKFTMSEEGINQAFERLEAGKVQYRVVLLPPAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAB6</accession>
    <name>A0A2T4CAB6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1399637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAB6"/>
    <dbReference type="STRING" id="983965.A0A2T4CAB6"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="53" mass="6251" checksum="0C45181ADC580977" modified="2018-07-18" version="1">MNEDVQFWKWISESTLGLITTSSVYHWDVYDASQDAPVKVFKRNANLNVRQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAD4</accession>
    <name>A0A2T4CAD4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1373116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAD4"/>
    <dbReference type="STRING" id="983965.A0A2T4CAD4"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="18245" checksum="A5513D359DF74F42" modified="2018-07-18" version="1">MGFPEAITGGCLCGSIRYSISRSAATPWPPQSSACQCTMCRKWTSSLIAQFIIVLPSQIEPAFNSHGTFEEYESSPGRFRGFCKRCGTSLVWRSADDGSTVDIFLGTVDEKWLVHEDGGRVGQVLARPNGTQFWMENAIPGVTDLVKGGREFLREGEDGWERKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAR7</accession>
    <name>A0A2T4CAR7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1198290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAR7"/>
    <dbReference type="OrthoDB" id="10629627at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="182" mass="20372" checksum="A65D9874699207A6" modified="2018-07-18" version="1">MRHLYDRMHEALWTELFSPLGRPRRGSVTTVLFWIHTLPLPAFGNVNHHRQQPVQSRPWPPQPRCWAAASRSSDHIICSESKQTNAPDTSGLGLSAASHPLCLSGCRIWQRHDRQRFAVAGLRAAAKPAPARQPAPSYQLKIFGSGLGFHPRHLTNHIALHVTSFRRIGIMESEANDSAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB04</accession>
    <name>A0A2T4CB04_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_49924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB04"/>
    <dbReference type="STRING" id="983965.A0A2T4CB04"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="751" mass="83053" checksum="554C0A3358EDBE42" modified="2018-07-18" version="1">MPSFDLTGSSLPEAQPSLANPVEGSGLSLDRRPKKSSTTCAVCRFRKVRCNGQRPSCGNCQRLGFPCSYDDADVDTWSLSLPRRRVKQACLSCHSRKARCSGHLPSCERCRAQGIECVYRPNKRSKPSSAGAGIAGSKSPNSPDQDSDRDGGRERRGHDEGRNDSPALTDRASSASPGVDNQGPQIDESFNSIVGRAFDLFFRHVHHMPMFTFLHRASLMEQYHAGKVDRALLLALVGITSCLTNMGPGMREYGSRCIDDAEALLLADYSRPSIVKIQALIFIIKHRILCNKFSSAFVLHSFASRYASALRLNYEAPHLRFLAQESRRRLMWALYCIDTSICGGYPDFVLWRADQIHVYLPCNERNFEFDLPQQTEKLVPDSHQPRPPLAEDIGTLALHARILHIRQKIIEFTKVAQYDRGMEAAELQGRIFALDKELNDFATNLPTSFQFSENSLRLRAYSPRLCIFVMIHVWWRQCYCDLYRLALVNISGGLPQSMLDMFDQSFLEHCQRQCVDHSLALTLIFSLIQKLGAKPVADIDLAMCAYQCARMLMYLFQLGIFDRFGVTAETVMEQARLCLQTIKDCCVGPAVDCIVADLERLINQDPKSGTREGLTAGTPNLQITDGPDVLSAPAATGLQPFSSASGAVNSAVSPFTHPVMTAPWMSETGFASGLDQQSLPPEVHANPSKGATPSLSAPRSEFGQSDLNAYDGTFAGLGLDDGFDYAMGLDMNMWATNGGSWTAPGYGNTWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBG5</accession>
    <name>A0A2T4CBG5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1327977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="KN_HD"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="590" mass="65949" checksum="3B54393EF447624E" modified="2018-07-18" version="1">MDQFGPSFFSPSDPYAGSPYASPAGGDSVFPDFQYELGPEMLSGPGSSYDGTSPLPFGPGPASHAESLWETEPQQHHSHHEQDNARNLNVIDEFFIKNGAHRPPVPCNYCQRLRLQCLILQTTEANPNPVSSCSSCVALYRDCSLAERGKREASAYETVLPVIGHLHGVREDVDGSTANKGGTQWRIEREAAPVPTRSSSIASYKRNSTRSVKKTRVLRNWFATHQEHPYPSEDEKCLLAEQSGLTKTQVINWFANARRRHRLTAQSHFNNSSKVFLQGSPMPQTFLAGMSPMERWRHSPPNEEPVSASTIENAISNQMHAGGGEGYVHSFDGSYATDGAPSSASSESAIFHQRPSGFYEASSNSGSSAFSMYQSDDAGIFSLSARSSIHGSDGDIMAGTSHARVATKAAAHHGRAHMFQCTFCHQSFKKKYDWVRHERSIHLPGLDSWVCKVPLPDDQSQVVWRVNHSEPECIFCGQTSPTDDHMQSHEFQSCAERPVSERTFTRKDHLWQHLHKFHRCRKWDGWKPNLHLLEHRQDAYESVCGFCQLQMHSWEERVQHLASHFRRGATMVEWAGSDVSRGREASLPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBY1</accession>
    <name>A0A2T4CBY1_TRILO</name>
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    <organism evidence="1 2">
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="134" mass="14789" checksum="60E322BFBDC030C1" modified="2018-07-18" version="1">MTPVRRSYLSLVVVVITSAIRRHVRVFSLRKASIARNSFGIAPTRLCRNFSFTRCGSSCCFVTAGTTKLILLSPFSQFIQMTISELVSDDVDSTGQPGSSPDLSILPRHKPLTFNLTSSFGLAVTDRLSFWPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC16</accession>
    <name>A0A2T4CC16_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1326944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="983965.A0A2T4CC16"/>
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    <dbReference type="Proteomes" id="UP000240760">
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        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="284"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="521" mass="59096" checksum="155AB1CA345DF800" modified="2018-07-18" version="1">MLRDTRKNIFACETCIPEVESFLKAIESKVKSPRLTGLPAFIRKLRKEHDLLQLVQSELVDDAEQDEHALNLLNRKLVASATIVQHAAAHWDILKRCRSFLVVDQAFQGSAKEDRKKQVSQVAGDGREKQRMNRTLKEQAKVEVDVVEGGNEWLDIRWLQADRLARQMTDCGWSWGDYGPGDVVDAEEWADTPLAKQVKRLVAAAKMNRHEYRIPRLRIVFPNLSRGENEDVDVFLDQICRIDPLVEVIVEDSSSQFMKSPPPPLQEAIQNLIGNELDGLTDTLNMDHTILVDLISDITHLQLQPQPWQAQTTRLQIEEERQQGGVMVRALYPILRGRTLVCTQEAAEHFHQVLSTVGTATERERGRLLVPFGDVDTRGMSTEEIRKRFAQLSVHKLPDDLQLPIKILDETWTMATVDQAVADGRLPQVARDVAKCGAFKSSKLSIYMYGWATSNITITSNKEVRGQIRTWVESNRRHDEERGPAIWRIDVTRNLLAKSATPPSTSKSENGLNGSTEPRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCM3</accession>
    <name>A0A2T4CCM3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1398588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCM3"/>
    <dbReference type="OrthoDB" id="5236168at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="291" mass="32713" checksum="089DCC9A6B25F9D5" modified="2018-07-18" version="1">MSAAMQLSKGEDQAQSRRRANSCIGWHCLNSVTHFGIIFSIVVTFLILSVVWMYCMGRARIFRKQTEEQHTPDRRRSNPRRHTPENMARPVPPPIVQQVPVFNYAVPQQAPMYFIPGPQIPTTLPFGIMNAHVQFPAPTFRQQEAPYPSHPSGMASGFPKAHEHPQEQVEPEDNVFPSRQPTWWQRFYRAFTLPVGDASTVSSSSSPEPSESSQVADADIKPPTASPRPDGLKVRFDDQREGKELQLPIDDEDDISSMLCNLNTSSDSLSSIRSDVATVHSDDFEATPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDE6</accession>
    <name>A0A2T4CDE6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Conserved oligomeric Golgi complex subunit 4</fullName>
            <ecNumber evidence="6">2.7.7.87</ecNumber>
            <ecNumber evidence="7">7.2.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Threonylcarbamoyl-AMP synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">M440DRAFT_1436810</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32 33">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="29">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COG4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="6"/>
    <dbReference type="EC" id="7.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CDE6"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="24" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-0653">Protein transport</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="31">
        <location>
            <begin position="1888"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1062"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1421"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="1069"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="PTB79552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2286" mass="247909" checksum="FF4EB41A999E5CE6" modified="2018-07-18" version="1">MQLPWAGRGSGSESLLPMSSVPIINGDIDDSSRQGRSETRPGHTRTSSAHARGVAREYSFMTPSEAAAQLRTSLTYGLTPNEALKRLSEYGPNEIPHEDPEPLWLRFLKQFQEPLIVLLLVSAGTSLLLGNMDDAISITVAVTIVVSVGFVQEYRSEKSIEALNHLVPNHAHLVRGSPNKSNLQKPPAWPPSINDPLDPADSSGAITPIEDILDGTSFKVSASQLVPGDLVLFTTGDRIPADIRVTKAADLTIDVSNLTGETKPVRISTEAEPHGLNMQAFNQSPKPTSLSPAPPMGNVESSDSSNARNIAYMGTLVKSGHGQGIVFATGGSTHFGSIASSVSGTENPRSPLQLSMDDLGSQLSKASFVVIGLISLVGWLQGKKLLEIFTISISLAVAAIPEGLPIIVTVTLALGVHRMAKHHAIVRWMPKVETLGSVNVVCTDKTGTLTTNHMTTVEMWCFGEDGSFNVASDAEVEEFKPTQAALHIVRIGNIANNARLSKNFTESGAATSAVLSSTLGREEASTYTRWVGQPTDVAMLDLLDKFKEHDIRDSMGPRVTEVPFSSERKWMGVTVGSEKEHAYMKGSIEKVLAACDTYLEKDGREIVLDNARRQEALAAADAMASKGLRVLAFASGQVARSSRTRTSAADTRSNTPANGASSPVVPQGSEDVYKGLTFAGLVGMRDPPRPGVERSIRRLMRGGVRVIMITGDAETTALAIGKQLGMNVAVPSAHSPGQNAVKAVLRGDEIDSMSDDALAQAMQHTTIFARTNPDHKMKIIRALQSRGDIVAMTGDGVNDAPALKKADIGIAMGRHGTDVAKEAADMILTDDDFSTILRAIEEGKGIFNNIQNFLTFQLSTSAASLALVFVCTCFGFKSPLNAMQILWINIIMDGPPAQSLGVETVDPDVMNRPPRKRNDPVLTTKLIQRVLTSAAIIMVGTMLTYRQQMADGIVTRRDTTMTFTCFVFFDMFNALSCRSESKSVLRGEVGLFANNLFNWAVSLSIVGQLLVIYLPWLQEVFQTEALGLGDLVRLVMLCSTVFWADELRKYLKYGKRPPMSAPNGVLRGSSSTSSSRAVTSSATATTTTAAATTSTALQNATNEVELRATLAALHERESAIMARLDALVESQNDLSRDLGRLDLLRAGLGAQVIAVRGISRDMLMTAADTAGRLSNRVKELDLEKSRVEATLGVVEQVAELKACVNGVVGSMGAPQDWEAAAGYLARASRIPEAIARGAFAADIVPSVEVPDAPWITLENARESLCGLFLREFDKAAAEGDGAKVTRFFKLFPLIGRADVGLDVYGKYVCQGVAGTARATLKDGMAGQNRKEGIIYANSLTRLFQHIAQIVEGHGGLVERHYGAGKMVRVIERIQMEADVQGGIILDTWSDERGVDKKLTDVKSYPFSFLVQSFLPQPPRGGIPRMNSPAAGAGNNPRNSEDEGVNMKEVDGLLHEISVMLAQWSFYTRFISVKSTDPELQDAPLRLADLLVKSKLYAKVSSKLISPYNVMSTFFFRRSVEKAFQLDEYPSGLSLSLNKPIEGNTPYIILAVDDVMYIVNAVLQRCLSTSQKDVVTSVVPSVSRVLTGDFVGMIQRKMRDESYPKAAIQGGFPPEDKIIQFIVLINSLDMANEYLTRIIHSRIGSPDGPTQQKEEIEAQLKQSFPFERDAVVVIGALRSLETAFLGKTTELLNEAIQVLFNQVVKLRLRPVLSDTFRDADYTLTEEEIAEIAQENDAPEGELLDQVARRFEHGWDQLMKAIGRIMTPGTFSSLMDMTARYLSRILEKRILGYGGRTSAYGAIRMERDFTAIVDVVSRGNYSVKEVFSRVTQLLMVANMEDDEWEEICAQNGEDGIDWVLTEDEKRRARSLVRGLEEWHILPSSSNDASIAALESAAAYLRTSNTPVAFPTETVYGLGADATRSAAVKGIYAAKGRPSDNPLIVHVADLRMLRELLGKEKDDRDAIPSRYGALIERFWPGPLTILLPNPRPSRLAPEVTAGLETFGARMPSSPLALSLIKLAGVPLAAPSANASTKPSPTAAQHVKDDLDGRIEFILDGGPCQVGVESTVVDGLCDPPVVLRPGGISMEELRSCPGWENVVKAYKDHSELGKAAPRAPGMKYKHYSPKARVVLYESTYTDGSEGVLPSDALDVAGAAENGDAEKTNGHSSRRIGVIRTKRWKAGAGLDCGDLQPAPVDHDAHDDEYLSPAYQVFKGHFKNKQGDVVGELFDIDLGRDTKRIAQGLFSALRELDRRNIDTIFVDGIDGELDIAAAVMNRLRKAASEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDJ4</accession>
    <name>A0A2T4CDJ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA splicing factor CLF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1326571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDJ4"/>
    <dbReference type="STRING" id="983965.A0A2T4CDJ4"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="346"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="81761" checksum="6D70193FFC8CBEE8" modified="2018-07-18" version="1">MSLPKPPSASSLDSSCSVIHDNVLYSYSPNGFLKLPLEDSAEWTQLDMGVKVTDGTCVGTTPPNAADAALFIVGGTSDVADYTGLQKYTFSTGNWTTITPSVPVTQNRLHHGSTYIPADDVILVYAGSQDGSTGPSSQTFTIQASEPYAALSFQSSAVPAVSPLVMQWSAADAAMMSGDGVDGKIYWFNPAAGWRYSGAGVLPPINTASGSVNAALVSGGDGSKNLFTFDLSKSPNSVTRTIVQDATGNPLADSAPIAARSLDEDAAESMEKRDAPTLTNWPSYNSTLAPKDTRTNYAMAQAPDGTVVFSGGNDQVPLAIFNPTDNGWVDAQKVLGDGKQSIQDVTSTSSSTKTKTSSSSRTKSTTHSTSTTHSASTTHSGSTTLPFTSATATQTAGFDPTDLSVPSIPTGTGSASDDSGPSSNAILGITLGAIGGFLALLGLILLLLRCRRRQMLHPEAGKPKTPPTDEKNTAAVAAQSAMAKNTLPPHVQKQIRGHQHTASSESTSSMAILMGRVGQHKPKQLSNDTIKSMTAHNQFKSTIGKPVLQPQQAPILQLQNEKGDTLATSAELRPQEGLAGVDDETRRSSGWNKYWSGGSALQILGYGAAQPSAQATEQPSAQATAAQRSTVVSDRSSHYSQVTNVRNVRATQDSATVPPLNFEAPPGMSRVNTGSPVVSHYHDIPWKEGMSGKIERPTSTVSALSATSSGYSSGIPESVQESWDPTHAGKAWGVDRAPSSAYAPSITSGQPYALGVSKQPQLTTASTSNDMSWLNLGDNSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE11</accession>
    <name>A0A2T4CE11_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1326081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE11"/>
    <dbReference type="STRING" id="983965.A0A2T4CE11"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="39"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="350" mass="37592" checksum="EE85A5FF898DF49E" modified="2018-07-18" version="1">MPSKSSWIALGCEGSANKLGIGLIRHTPTSTTILSNLRHTFISPPGTGFLPKDTALHHRTEFVALARRALAEAGVSPADVDCVCFTQGPGMGAPLTSVAIGARTLSLLWDRPLVGVNHCVGHIEMGREVTGADNPVVLYVSGGNSQVIAYAERRYRIFGETLDIAVGNCLDRFARVLSISNDPAPGYNIEQLAKKGTRLLDLPYVVKGMDCSFSGILASAEALAAQLLQLGPGPDGAGFTVEDLCFSLQETIFAMLVEITERAMAHVGSSQVLIVGGVGCNERLQDMIASMARERGGSVFAMDERFCIDNGIMIAHAGLLAYRTGFRTPLEESVCTQRFRTDDVYVNWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE23</accession>
    <name>A0A2T4CE23_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1429058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CE23"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="229" mass="25749" checksum="60A19A18C452BEE1" modified="2018-07-18" version="1">MKTILSQPLRFLRSTGFSGGANQARWLHKTRPAPTIPQPRPFVPDVQTFLTLIGRGLSKHASKFPSWESLFSLTSPQLKELGIEPPRNRRYLLQWMQRYRQGALGPGGDFKYVTDGQALLKVATPPASVVSDAKYVVNVPMDQEATLEKDEILPRPNGYTVRGLKSIAGPYATPLPQQAGAIVKVTEGMWEQRQGRKIDGGERRRAEIRFKRRSVERRAEREAEALANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE97</accession>
    <name>A0A2T4CE97_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1324094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE97"/>
    <dbReference type="STRING" id="983965.A0A2T4CE97"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB79864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="509" mass="56829" checksum="765022897071608A" modified="2018-07-18" version="1">MAHSPSSSSAADDPAENTADEEDSEDYCKGGYHPVQIGEKFKDGKYTVVRKLGWGHFSTVWLSRDNTNGKHVALKVVRSATHYTETAVDEIKLLNKIVQANPNHPGRKHVVSLLDSFEHKGPNGTHMCMVFEVLGENLLGLIKRWNHRGIPMPLVKQITKQVLLGLDYLHRECGIIHTDLKPENVLIEIGDVEQIVKKVVKPETPDKENNRNGRRRRRTLITGSQPLPSPLNANFNHNNLFPSSASQGSLGGMLEGKQKDESSTADDAQSKREKSADLLTREVSGISLDKSSTPSSTSTSDKRKADDAHAYDIISVKIADLGNACWVNHHFTNDIQTRQYRSPEVILGAKWGASTDVWSMSAMVFELITGDYLFDPQSGTKYGKDDDHIAQIIELLGPFPRSLCLSGKWSQEIFNRKGELRNIHRLRHWALPDVLREKYHFKEDEAKRISAFLTPMLELVPEKRANAGGMAAHPWLDDTPGMKGIKIEGLEPGSRGEGIEGWACEVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFF4</accession>
    <name>A0A2T4CFF4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rpr2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_16517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFF4"/>
    <dbReference type="STRING" id="983965.A0A2T4CFF4"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="22198" checksum="401F3B652058FD2E" modified="2018-07-18" version="1">MAKAKGNPGIQNRHIYTRASYLYQAAVYLANCAQREEVDSKKETTLRTSQHDDDSTSSRPRREAPSGREISEKHENQERKATMNLSHQVVSDMRSVSLKAQIRQGSSIKQTICKYCDAVLIEGKTCHSFVENPSKGGRKPWADVLVIRCDTCGNVKRYPVSVPRQKRRAFRTAQNAGTPKMEEDGAPPAPAPASELPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFJ9</accession>
    <name>A0A2T4CFJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1122616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CFJ9"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="626" mass="69300" checksum="97793B91D97F3D61" modified="2018-07-18" version="1">MARKDDASYYTSDRLISRIQRTHFRVPVRSQHWQLRSLISAENKHNLFYPGGVGSRQVQRLNTLARSCETIKHLTFAPRCLVAENGWLCCGSETGEFVAIRLEGEGGRAIENPQNPSSGSDSEAGPSSEDSTMSPEEAALNMLTAAAQQSAKVTAKSMKLAKERVNCITLWFPSPAGQGLPVDGRAYSEPVAVLANNDRTVTLVSLNDFDQKEVTEPLEVVHYPDFVNRAVISPDGRLLIAILDDPYLYVHQRAGPFPGKWELKQRILLKSQKKDDKTDSRGSFAASFSTSGAYLAVGTQHGTISIFNATQLTDETVDPLITTFQSSRPNSGPGAVRDMAFCPGPYDLLAWTEDRGRVGIADVRHNFMVRQIIDLNKESEYEHINIFDTQTIDPRLLETRMTRGEALNPPLTAASLFNAQMLHQPLTPAETRVLEAIQTERRRRDRPNGQFGEERGSGGATGWIGGTGTTPPATSSFTTRARQNTNQIPNELLNVYRDHRERAQERVRNARQLLRESGPGAGTRAEQRWIDRINETMAALRDQRDRQDSSYLSVLEILQARERASADSSSAVDDRPILPPVVNQVASRWEESAVRGTLAPDHGVFEVPPSPDNTSGLSWSQDGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFP4</accession>
    <name>A0A2T4CFP4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1348265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFP4"/>
    <dbReference type="STRING" id="983965.A0A2T4CFP4"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB80364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="16858" checksum="E0FBC52B5E7501D8" modified="2018-07-18" version="1" fragment="single">MLSFILIQNRQGKTRLAKWYAPYSDDEKIKLKGEVHRLVAPRDQKYQSNFVEFRNNKIVYRRYAGLFFCACVDTNDNELAFLEAIHFFVEVLDAFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFS9</accession>
    <name>A0A2T4CFS9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1418992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5397682at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="78581" checksum="1FC38BB46B78B5D8" modified="2018-07-18" version="1">MAPPATRGWSLSQLWRDDDEEMASKKDDDIGLPRHSRHSDQWQAAPRSSLHWTAVLRLVVYAAALFMLAYGLFRVIGPAPGASSLDPANLMPLYDSQRPPPRYDAPRMEEEGPSIKSAQTSKTQEPQVHAKGSSGSHKDESRVAAEISKTYNGPLKLPHLGKSLQAIMSETSGRLQKNRNVLFAAGSLQSAALLLPMACQMAMERQNYVHFALMSRSDVPMKDLLAVNGLDKGCPLIVHDARPDHSTTATEPRMALSVARALYYMSVYMHPQAIVIDSSSTEEKYFLSGVRDEIQSMTSTLIELPERPGKRFSWLSKLDASSLAAWNDVSFDILIQAPHHGTGNLKRLLKSLARADLAGMSPPHLTIELPTIIEGDLSSFLSGYQWPPKVPAGAPKPRLLSLRHRIPRQKLSEEESSVRFLESFWPTKPSHSHVLVLSPHTEVTPQFFHYVKYSLLQRRYSEIATSQDWQAKLFGISFSAPTTYLDGNSEFIPPKPLEGHESGAKDTPFLWQAPSSDAILIMGDRWVELHGYVSQLLDKRHTWSTTTTPDLLAKKEVSKKYPAWLEYTLQLSRLRGYVTLYPTQQTANSVVGIHNDLRDVPEEYEDEATPGQDSTNLSADLFDPASQVDMLATLPHGGELPLLYHIPWLTWDGQQAQDFNIREAAAKYKETFRSQVGQCKDEGPEAFQAPDPYARDLFCFAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFZ4</accession>
    <name>A0A2T4CFZ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFZ4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="62" mass="6937" checksum="8E7610FDC163C6C3" modified="2018-07-18" version="1" fragment="single">MIDHDLVHDLDSNHDHGADIDHGVDNESGSRQRQGQQHRQHRPRPASIWDRDSAGAVALPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG94</accession>
    <name>A0A2T4CG94_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA splicing factor CEF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1388810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG94"/>
    <dbReference type="STRING" id="983965.A0A2T4CG94"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="589"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="69360" checksum="901636E4C3934198" modified="2018-07-18" version="1">MPVVKGGVWTNIEDEILKASVSKYGLNQWARVSSLLARKTPKQCKARWNEWLDPSIKKIEWSKEEDEKLLHLAKIMPTQWRTIAPIVGRTANQCLERYQKLLDEAGGSPGHSGKRKGEGDDDNDRKRRKNDKDGISESQKAAIKAGQMQRIREAEQSSKRRPLNLPAPQVSEGELEEIVKMGKMGEAANLMAKESDNDATRGFVNSYSTLNTNAPIRTPRAPAQEDHIANEIRNIRALNETQSALLGGENTPLHQGSGSTGFEGIAPRKHVMATPNPLATPLRAGGVNGAAPGQTPMRTPRDTFALNQEDGTTATGATPRDVRLRQMAMRNQLQAGLAALPKPKDTEWEFEIPEDQAPTAASEEALEEDAAERDRRERQRREAEEALERRRQTQVIQRGLPRPVVVDLTELLERAKNIDDPAAALIAEEAAALMANDAAKFPLSGSKVKGTLRPLSTIDDGLLADARLRILSETKPLPSFEDIQAAFESRAGGDSLLLGLGCYSDDAAEQDAAMRAAFDAVQDSIMLSAEEDAKLEKKLTLHLGGYQKRQKMLKDKVSDAADALDKAKVALAGFKTLAISEDVAINRRLESLRDEVNFISRREREAQEEYRKAKEELEALRAGDVNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGA5</accession>
    <name>A0A2T4CGA5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1397951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGA5"/>
    <dbReference type="OrthoDB" id="3880401at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="236" mass="25692" checksum="4FD9CDCADE1A6C3A" modified="2018-07-18" version="1">MASTNGSSSTADVSVPDQLFHTLLTVADPSGATRTPFVLKSHGTLAAAKAFARQSLETLGFAPELDFELYRVRGPQDPPPSGSQPWTHGDGVLVFARSFDGKEFVVGIETTPNNESLPASPADGELRLPDGARLLHYVVQIIVDYNTDRSGAAQTTEILGAYVHRANAWKAAHTCLDPAEYAEFDRRGDGEFVEEWPFGDDVAVHAVSENGQNCWVAVKMPPEQKHDLKPHNLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGI5</accession>
    <name>A0A2T4CGI5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1323720</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="18">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="18"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGI5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGI5"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="357" mass="41148" checksum="6093AC63508D6E52" modified="2018-07-18" version="1">MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSARDQLTNQNVAVKKIMKPFSTPVLAKRTYRELKLLKHLRHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQPLRNKFKNADDSAVDLLERMLVFDPKKRITATEALAHEYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNIEGGVPNMDEQFPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGS8</accession>
    <name>A0A2T4CGS8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_203256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGS8"/>
    <dbReference type="OrthoDB" id="10555307at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="220" mass="24688" checksum="98EAA8F9DB4BA357" modified="2018-07-18" version="1">MTFVQFERKQQEVRQYMSLLIANPSLNKRRSLAVDPCSGCPSAGEMRSSKACGWLSYYGNGSGMLSPAVIEWNNREKHPRLLLAVRARLRPISTSRIRTASTCTRQTASICISCSLSPYCSCARTRGPTRSWRRVGPAFILSPSSTEQQQDYGVLQWVWRMPNGLAAFASPHLELRDGAGEMLRLDPGFLPRFRLAVGGRSCMPWRQSACFLRTRTCLCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH64</accession>
    <name>A0A2T4CH64_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1434811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH64"/>
    <dbReference type="STRING" id="983965.A0A2T4CH64"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="374"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="478" mass="51858" checksum="5C31422ABC5DAC74" modified="2018-07-18" version="1">MEAPQPAQDALHLSALASQNAASTRHLYARLELANGKRQKLEGVFQDPVMKRRFEAEYAAVQTLPEALAAKQPSKQPGRKTTTAVARTTPAGPARKTPKLLEAGPGASSTSSSPSKAAASGGGSTTTTSTPAAARQNMSLTVRGASAIQQVKPEWHPPWKLMRVISGHLGWVRSLAVEPGNKWFASGAGDRTIKIWDLATGSLRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLSLHPTLDVLVTGGRDGVARVWDMRTRSNIHVLSGHTGTVSDVKCQEADPQVITGSLDSTVRLWDLAAGKTMGVLTHHKKGVRALAVHPTEFTFASGSTNSIKQWKCPEGAFMQNFEGHNAIINTLSVNSNNVFFSGGDNGSMSFWDWKSGYRFQSFDTTAQPGSLDAESGIMSSTFDRSGLRLITGEADKTIKIWKQDEKASEETHPIQWTPSLAHRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH95</accession>
    <name>A0A2T4CH95_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L35Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1434862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH95"/>
    <dbReference type="STRING" id="983965.A0A2T4CH95"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="107" mass="11837" checksum="FC99CA73942DB172" modified="2018-07-18" version="1">MPSESGHRCEGRHLSYQRSRHITHPGTSLIKIEGVDSTAAANFYLGKKVAFVYRGQKEIRGTKIRVIWGKVTRPHGNSGVVRAKFAKPLPSKSFGASVRVMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHB0</accession>
    <name>A0A2T4CHB0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal binuclear Zn cluster-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1002344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHB0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHB0"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006351">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <location>
            <begin position="302"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="1"/>
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            <begin position="60"/>
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    </feature>
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        <location>
            <begin position="747"/>
            <end position="770"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB80924.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="770" mass="85468" checksum="F39F8EF40EF2B9E7" modified="2018-07-18" version="1">MDTSSCSYAAPATRKKSQNQADATPDDMQNRIDRLEGLVLSLMHGGANVDPASAAAAGRAASTSQSLTDSGSSAKAGRGEGVTMVEDDSDSEDGLAASLGVLKVDPDKGKSMYIGQEHWHTLLADISEVKNYFMFHKKELETSYERVRLSKPMAAREGPTLLLGALPASEIELRAELPPKSSILTLCSRYFNSMDNAVCIIHGPTFFKQLKSHWEDPSKTPIMWLGLLYSVLTLAMLSYHKVGDEPPEWRGRTLELASQYRLRTVQCLIKADYTKPVEYTVEAMLLYVFGEYSSRWDADLGLWLIVSVITRIAFRMGYHRDAKWFPNLTPFQAEMRRRSWALVRMSDVIFSHQVSLPNMIYENDCDTQLPNNLFDDEFHPDSKELPPSRPASEPTPISYMIAKVKLCSELGNIMQATTMVGKTVPYDEIIRFDAKLRQVMQELPPHLRLGALEASQDPVTLIIARYNVDILYQKILCLLHRKYLARARHNPRYAFSRRSAIEASLQALDHLAKLHRESQGNGRLRSVSWYIKSIATKEFTLPAMLLVLDLHYDNLARQANNPPEEGVFLYTQEQRDKMIGALETAKAIWTDLANTSMEAFKATKIIEIMMEKIKVAPTDTMDSNSDPLSSRTDSLSASIVGSQIDQTPMSFLGSPLGIPGVGVGGQDPFMQNNAFMGMDFGLRGSNAADFQQFDALNAGGAASPLSMFTNLGGTGPGDLASFDWGAFENYTQMTTWGADQSFQIYGNVDQPSTDQGLEDGMLNGTGNEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHG8</accession>
    <name>A0A2T4CHG8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_73735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHG8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="15240" checksum="A0136A7D8832C001" modified="2018-07-18" version="1">MSQSTFMSPELFDGYEALIPARGASSLTSTTGTNGQGFDTTHRYLLRTTVCFLDLFCLFSVAMYSRCCKAISLGLSWSFPFFSGVIFGVLAWAATSRDSNDATGRPHLISYTFFFFLSFFPGLYGRPVDLGMGCCGLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHK8</accession>
    <name>A0A2T4CHK8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PK beta-barrel-protein domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1345447</name>
    </gene>
    <organism evidence="13 14">
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        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4CHK8"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054582">
        <property type="entry name" value="DmmA-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="Tri_helical_YiiM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22290">
        <property type="entry name" value="DmmA-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="YiiM_3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="11">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="238"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="467"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="550" mass="61573" checksum="8BE082AF6E78D6BF" modified="2018-07-18" version="1">MAKSYLEALAAPFEADRLLEIRTSGMKQMPGLTVMSGIDKQLRTVSMKVDKLGLEGDEHDLTFHGGLDKAILGYCSSHYPSWQESYPERVDKFVPGGFGENFVTAHMNERNVCIGDVISVGPEVVLQVSLPRQPCFKLNHRFSLKNFAPETYKSSRTGWYYRVLKEGHVSPGDELKLVERKWPEWTIERIQEYLHRQTDNDEMNEKLADIEALGDEARGQFKSRVAKAQRRKQQKKEEAWETYKVVSRKMETPRALSLVIEAPVKPQFDKFPWASHAKLRLANGLVRKYSVVSSQGNGESARRLEFCIALDDNSRGGSRYIHENVKVGDSIEVGSVVSDINGAVSAASHHVFIAGGIGITAFLELMKTYDSINWSFQLHYAVRSSDEVPYREQLESYGDRVTIYDKSKGQRMDISNIMATIPWNSFLYVCGPNRMMEAAKAAAEKAGIAPQEIHFEAFSADTTGDPFEAQVINRDNKVVKVGEEESLLEVLQREFGDIPSSCEVGNCGTCKVTLKSGKVIHRGSPLMPEEKDSAMLTCVSRGVGRIAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHQ6</accession>
    <name>A0A2T4CHQ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1321546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHQ6"/>
    <dbReference type="OrthoDB" id="3563866at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="14537" checksum="F7AEC34C8B3DBB96" modified="2018-07-18" version="1">MDTKTTTPRLTTESLGLSDSTQTTPSVSAVSTPTLESSEFIGGFPHKLSANLLPALSRDFPKPTDEVNVNEALERQPGRWSLKGQIKANNMRAQSAALRLDDKEDKARAFEQAKRELLAYHSSALQKHSGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI23</accession>
    <name>A0A2T4CI23_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_63237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI23"/>
    <dbReference type="STRING" id="983965.A0A2T4CI23"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="257" mass="28525" checksum="6BBCEE27E7AB1D62" modified="2018-07-18" version="1">MTRFRPCIDLHAGQVKQIVGGTLDSASEALQTNHVSQLPAEHFARLYRDNGLEGAHVIMLGGGNDEAARRALRAWPGRLQVGGGIRDENAKEWIEAGAEKVIITSYLFPDGHFSQERLDAVLAALDGDKDKLVIDLSCRRQGDKWFVAMNKWQTLTDMEINQESIKQLEPYCSEFLIHAADNEGLQKGIDEELVERLAEWCSIPVTYAGGGRHLEDLDTVKRLSRGKVDLTIGSALDCFGGSGVKFEDCVRWNRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI90</accession>
    <name>A0A2T4CI90_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_80190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI90"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="13297" checksum="DEE8855E23AE159D" modified="2018-07-18" version="1">MDTKVHTKSHPGPLNNRPSPTANHAPPRPPAMKHVSETTLKPPPDTTTHLIPLLNRYYQTPKPAAKRDHPSCPLEEESQKKLPPSPNSSIISYDNLFPPQSRVSHRFIPPPISPGMSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIM4</accession>
    <name>A0A2T4CIM4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1396540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. RimJ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIM4"/>
    <dbReference type="STRING" id="983965.A0A2T4CIM4"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF8">
        <property type="entry name" value="[RIBOSOMAL PROTEIN US5]-ALANINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="56"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="23462" checksum="F3C7BFB5BC64A6F0" modified="2018-07-18" version="1">MPSIEKNRILPSPCPPSSDPGTVLVETQRLTIRRYLISDAPALALAANHEQVASYMSDRFASPYTTADAEKFIQQTFHDDDTAAYPHGAAILLKPGFPGNPSSTDALLIGGIGTHALTDTLYRTWDLGYYLTPSVWRQGYGTEALRAFTRWVFETWPTLNRIQAHVYESNAASQKLLQKCGFVLEGRGRGAIEKGGKIMDQIDFGLLRDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIN6</accession>
    <name>A0A2T4CIN6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1435170</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Plastid</location>
            <location evidence="14">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIN6"/>
    <dbReference type="STRING" id="983965.A0A2T4CIN6"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF135">
        <property type="entry name" value="TRANSLOCASE OF CHLOROPLAST 120, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="G" evidence="16">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB81382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="291" mass="32995" checksum="82C3AF41A30A05C0" modified="2018-07-18" version="1">MTGSGKTTFIANATGRTDLQIGHTLTSCTQEIQIIETTIDGRTVRFVDTPGFSDTYLSDTEVLEMIADYLSAGYSKEMRLSGIIYLHPISDNRVTHHATKNLDMFRKLTGEKNLKNVILATSMWDKVTPEEGLNRERELQGNFWSVFMAFGAQYCRQDASAQSAKKIASLLMDNEPFFLELQEEMGKDNKALKDTAAGREVMSQLSQLKEQQEKELAEMKEMLRRTAAEENKAAEAALEHHYKKIMEDMKKTISDERRMNEEAAKSSEEKVKELTERIQKLENKGTGCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJD6</accession>
    <name>A0A2T4CJD6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1022022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJD6"/>
    <dbReference type="STRING" id="983965.A0A2T4CJD6"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="423"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="511" mass="58122" checksum="6FA470B22E2BF4FC" modified="2018-07-18" version="1">MSLKQEIETWVAALGRYDNNEFDEALAEFDKIGDTSKILFNMGVIHATLGEHEKAVECYQRAIRLDQYLAVAYFQQGVSNFLLGDFEEALANFNDTLLYLRGNSVIDYAQLGLLFKLYSCEVLFNRGLCYIYLQQKDAGMQDLAYAVKEKVVEDHNVIDEAIREEAEGYTVFSIPVGVVYRPNEAKVRNLKTKDYLGKAKLVAASDRSNAFTGFAGAEIRNALTEAKDDRPSENLSFAATNLVKPGLQSRRQQSEPPTDRSNAFPPTPPPENDRLNRGPSERNSGGRGKLSIQTQEPSRRYEKAISPQERSRHGRSASAAPARGISTRDPQRRQRPTEEDYPYGDEQYDPYAVGPRGSKGSRSRQQRYDDRYDDRYEDEEDSENDYGSFDEGEFEMVSTMRRGPGSVARPSRAASRRPPEIRKIRVKVHSDDVRYIMIGTTIEFPDFVDRIRDKFGLRKRFKIKMKDEDVPDDMITMGDQDDLDVAIQSAKSAARRQKLDTGKMEIWVIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJJ6</accession>
    <name>A0A2T4CJJ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1396918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJJ6"/>
    <dbReference type="STRING" id="983965.A0A2T4CJJ6"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="293" mass="32287" checksum="B48439293040651A" modified="2018-07-18" version="1">MAQKLTLQSTIKLNSGHHMPVLGFGVYQTSASVATDVCKEALKIGYRHIDSASAYRNQGPSAAGIAAAGIPRNEVFFTTKVPVREKPLGYQNTLDLVDIALQETQLPYLDLVLIHSPYGGSENRKGAWKALVESVDAGKVRSIGVSNYGVHHLDELEAYIKELEAERGSGKGGVLSVGQWEIHPWLPRDDIVQWCRARNVAVQAYCPIVRGQRFGDAKVGAVAKKYGKTEAQVLLRWSLQKGLVPLVKSVTPSRIKENADIFDFELTEEEVKELTTSEYSPCAWDPTVEPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP79</accession>
    <name>A0A2T4BP79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1442905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP79"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="482" mass="52753" checksum="BD83AAD7610EF1B5" modified="2018-07-18" version="1">MADGKSGSHAPSAHFEVTGIDAEPNERSLLRKLDRRLLPAVGVLYLLSFLDRSNVGNARIEGMVNDLHMTGNEYLTGLTIYFIGYVLFEIPCNVILKKTSPRLWLPTLTIAWGVVATLLGVVKNLPGFLVARFFLGVTESGLFPGVVFYLSMWYKRRERQYRISLFFSAASLAGAFGGILAYGIGKMAGVVWSNGWRWIFILEGIATIIVAVISYWFIENYPDTAGFLTKPERELIQTRLAADSDAMTKEEFSWAAVLEAIRDPNCWLYSLGFHTMSLPLYTLSLFLPTIISNLGYTAAKAQLLTIPPYALAFITTVAVAIASEKLGKRAVFLAGSSLVAAIGYVILLANTDPVARPGVSYVGTFLAAAGIYPSTALVLSWPAINVSGQTKRAIANAMQISIGNLGAVMGTQLYRANDGPRFVVGHSMALAYLCANAIVACYIGWRLKAENKRRADISPEVDNVGDAVNWKGDKDPRWRFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPC1</accession>
    <name>A0A2T4BPC1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_223269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPC1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015740898" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11039" checksum="5502D680AB858E7C" modified="2018-07-18" version="1">MTLPGPCRLSAERVLGLLLMRCMSATVTSFCVWQCGRMTAAESDYCVWMHEVAGESCQLVSSWLVYSWIQLTLMIWWQRHCRLGPANSSRVVDLPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQI1</accession>
    <name>A0A2T4BQI1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1406316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQI1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="13711" checksum="D1DA52061F701DF3" modified="2018-07-18" version="1">MTVRTSGYTALNTSAYPIARESHRGVALRSMTSRSAAQSSFPFESPSLGFVSPSMCRCYVLIRACGFDTSLCLSEPSFHAPTSFRQLTQRTKFIRAHPSTDIIMYARKPAGQEIAMKPDRRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQL3</accession>
    <name>A0A2T4BQL3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GLEYA adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1473412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQL3"/>
    <dbReference type="STRING" id="983965.A0A2T4BQL3"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLEYA adhesin" evidence="1">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="208" mass="22950" checksum="7863D3051A1D077A" modified="2018-07-18" version="1">MVNPARVHVIAAPAAHLGARTQPSPTCDPSQTKTLLTITIGGTHTKTVTETTITTTSGSHIFTPPSCPTQSYCNNSARNTDTTYSSFHRDFFKKTAPVYCFKMTRAIYDSSQAFALDFLALNRHAYIYACEGGICTVDISYSNDSVYLMTGAKAYFGWTDANADAKALYERPHHVAGRASFSFDVPADTYVPICFFYGQTQKCKWLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQW5</accession>
    <name>A0A2T4BQW5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1364934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQW5"/>
    <dbReference type="STRING" id="983965.A0A2T4BQW5"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="80"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="263" mass="29131" checksum="88907AA527FCEE67" modified="2018-07-18" version="1" fragment="single">MADDDEGWTRVRPSKWANRLQSTNKAAANLANPGAKPTTVSPAVVAQLERELESIRGDLDAWFPQAELRGIFSAYAAAFSEHGQGPVSQIVCFGIGCFDHPDGNWQAKRTSYCQLAALLVIAEQLATDANREPYQIIFQEPAFNLNDVAFIESLGHMVVEAPKGSDFIDCNTLFYGPHLYYQLYAEALQGQLPVVYVGSGIDSWELKPLPSTHLLPRNFPVTIAPLKKIFSQYQRFKFPEVKGGVAFHGTYICLRPPQAQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRU3</accession>
    <name>A0A2T4BRU3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1097798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRU3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="85" mass="9482" checksum="4BC8E6D3834291E3" modified="2018-07-18" version="1">MTRISPPTISHYLLPLVLLFSRILYSSGVTVVVLSPLHTGPDIDEQEKPHADMERAQLQPGISPALRSTGYQPKSGKRFRGPWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS07</accession>
    <name>A0A2T4BS07_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1098844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS07"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="82" mass="9143" checksum="D82DFBCDCC81D260" modified="2018-07-18" version="1">MHCSSCPYLAPAITSHTRPEPLVLFSPPCACLYLAILLSIHSHLVHCSFLVPRSIQERGNLYLHNTYQCPFDISGYTGRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS90</accession>
    <name>A0A2T4BS90_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1100584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS90"/>
    <dbReference type="OrthoDB" id="5152716at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="15186" checksum="2D5EAF0CE539D0BE" modified="2018-07-18" version="1">MGDLLHIQGKPRKCNEKERKAACQTSIDIHPDNGPKGSHRQGRDHQEENNSLYSKRSRLLPPSLRTVREDQKSIHSWMSRICNHQPGWIRWLFWEPKRETNTIEMILLQKAVSKTRFSSGEFFCCWQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSN8</accession>
    <name>A0A2T4BSN8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1342019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSN8"/>
    <dbReference type="STRING" id="983965.A0A2T4BSN8"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="443" mass="49006" checksum="1057CFE1EC920C5A" modified="2018-07-18" version="1">MSVRSQPSEKVDPAPLGQPLEFEFSGKVAKNRFLKAAMSELQASWDAKDLSKRGIPPKELVELYRRWGEGGFGVILLGNTMIEYDHLENAGNHIIPRDAPFSGERFERFKEIAAAAKAHGSLVYPQLSHPGRQVQEYIQPNPISASDVQLVGSAFGSFAKPRPMEKEDFENVINGFAHAAEYSYKAGFDGVQLHAAHGYLLAQFLAPSTNRRDDDYGGPLQNRSRLIFEITKAIRARVPDKSFSLAIKLNSAEFQKGGFSPEECRELCAELEKSGFDWVELSGGTYESLAFEHKRETTIKREAFFIEFAEMIVPELKKTKAYVTGGLRTAAGMVKALESVHGVGLGRPAAHEPELPQKILDGVVEGAIKPLFGESNFMITNMAATTQMKLIGQGYEPLDFSRPDHEKVFTEALGKWMELSKSKGPQGPPTIEGFELKPYGTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSX8</accession>
    <name>A0A2T4BSX8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">M440DRAFT_1341982</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSX8"/>
    <dbReference type="STRING" id="983965.A0A2T4BSX8"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="327"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PTB72398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="695" mass="78854" checksum="E469B4F7F98D2F63" modified="2018-07-18" version="1">MYSQSHQQGHNARLNGAGRGMPNMLYNFQQHAQHQHPSQPQHHQGLQHDHMLPGANGLGHHSSFASGLLSTSASFNSASMSNGHANNARAGQAPQNEMWQEQLRLHKEAERAHSAMTEQQQPHYYARLKASENRGIGGPPPSNGKTQADSENDPADMRRPLNVDKGPTRQDWHNLDMSGQGLRNLASELFRYQFLNELYIASNKLTRLPNAIGELRQLRHLDASFNQISELPPELGMCTYLKQLLLFNNNLQELPFELGSLHQLEMLGIEGNPLEPSIKQEIMEKGTKSLINALMEGAPIPLPPTPRKEIIIQEDVPENLERIRVFSWNILCDKYATTQTYGYTPTGALSWEYRKNCILEELRIRDADFLALQEVSTDAFKEDLSPELAQMDYKGVHWPKSRAKTMSEKDAQTVDGCAVFYKQSKFILLDKQLIEFASIAINRPDMKNQHDVFNRVMPKDNIAVICFFESRLTGARIILVNVHLTWDSALADVKLIQTGILMEHVTKLAEKYARWPAVKDKKMITLPRSDDPDEPPPPPQAEPGPSQEYRSNTDIPLVVCGDFNSTKDSSVWELMCLGRVPPDHAELNNFHYGSFTRDGIEHPFSLRDAYAPIQNTPDELPFTNYTPGFADVIDYIWYSANTLEVVELLGPPDPTYMKRIPAFPNWHFPADHIQIMSEFVIKNRKDKKQVSDNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT41</accession>
    <name>A0A2T4BT41_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1384493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT41"/>
    <dbReference type="STRING" id="983965.A0A2T4BT41"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="215"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="602" mass="67323" checksum="D839D9142A2124A1" modified="2018-07-18" version="1">MTRRIVRTLTQLGAVVFVTTIIIFFLDRNYRVLPNALHNYMPSHHPGLVVTDITLTTCSSLKPFSSCELNPNEWQRIEKELYLGRAWTSKAYLHVRRKREEELTEDDKVVVGVSVGSLNPGDVADGAEHWEPRPGGIWLKRSRNKKSSDSDAAVTDVDVVFGDDATEARNGWGIVGRPLHLGTGGNLLSAHLTVRRGAPHQPKRPKPRIPDNGRFKIMQVGDLHLSTGVGECRDAVPDAYKGGKCEADPRTLDFLTKMLDEEKPDLVILSGDQVNGDTAPDAPSAIYKYASLLIERKIPYAAIFGNHDDEKSMSREGQMALMETLPYSLSQAGPVDVDGVGNYYIEVLARGHNEHSALTIYLLDTHAYSPDERHYPGYDWVKPSQIDWFKRTSASLKKNHDGYTHRHMDIAFIHIPLTEYADWDKPRVGEWREGVTAPVYNTGFHDALIQEGVVMVSAGQLTKGKLQSDHVNDYCSLSSHGDETKSFLPGWDQKLPLEPEKEKDDDVTNKVPAMWMCYSGGVGFGGYAGYDGYIRRLRLFEVDTEEARITTWKRVEFGDNAQARVDQQILVEAGKAYFAPPPQQQQQPPPGEGQGGEQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT90</accession>
    <name>A0A2T4BT90_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1394825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT90"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015672404" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33231" checksum="DA043F100B879D71" modified="2018-07-18" version="1">MRPSTFLVSSLAVFGARAAPAQPKIDLHDFKNPASAINSLTEYFNLVASKTEIAKVQPTAQLCDMSKAQMPAVDGLLPPPSANLTVKHVAVGRGTQNYTCDTSKPDAAPVATGAMATLFNVSYVACASADLLQKVPNMAVNFNFDAAAAGPLGPMKLDVSGHHYFLDSTTPFFNLDTPALDMGTVPCAKNSSIAAPSSSAPGPGGEAAVPWLKLTAKQGATGSIKEVYRINTAGGSAPATCQGQAASFQVQYSAVYWFWGSNRKMDFVVPMYIRSSVSRPMSKIASWLVAGGAEGILSAHTVGKTGKSEKRPDKVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTA0</accession>
    <name>A0A2T4BTA0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1405535</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTA0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTA0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000095">
        <property type="entry name" value="ABC multidrug transporter Mdr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="194"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="514"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="755"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="818" mass="88383" checksum="428D60D8FFBC8EFA" modified="2018-07-18" version="1">MNAGALRRALPPRLAVGGGLQESAAWSRGPLSQVRPKPESRLCQPQLLRPRALPSFTPAGFHTLAGSLRVSPYQYRASSQPQSHTGFRLRSSPGHGHILNLARQFSGTSSAAREVQSNTQNANQQALEPARQAKDTNEDEGSQEFQKSERAAHAAQVNLSARLSKEGKPQAKAGLKEIWRLISIAKPEARWLGLAFFFLMISSGVTMLIPFSVGRILDISTKGDIDNVNIFGLTLNQFFMALGGVLTLGAITTFGRVILLRIIGERVVARLRSQLYRRTYVQDAEFFDANRVGDLISRLGSDSVIVGKSITSNLSDGLRAIFSGGAGFAIMIWTSAKLTGILCLMFPPIAIGAFFYGRAIRNVSRSIQKNLGTLTKIAEERLGNIKTSQAFVGEIQEVHRYNKQVRKIFALGKKESLIAATFFASTGWAGNMTILAMLVVGGNLVRSGAMSLGDLTSFMMYTAFAGSSLFGLSGFYSELMKGVGAASRLFELQDRKPTIHQTVGVPIKSAQGTIRFSNVHFAYPTRPAVKIFNGLDFEIASGSNVCVVGPSGGGKSTVASLLLRFYNPTSGSITINGIDISTVNVKSLRRRIGVVSQEPVLFSGTIAENIAYGKPHASRAEIISAARRANCTFISDLPDGLETQVGARGSQLSGGQKQRIAIARALLKDPDILILDEATSALDAESETLVNEALAGLLRGHNTTISIAHRLSTIKRSDQIIVLNKDGQVAEIGSYAKLAADKDSAFTKLMEWQMSGGEIPPETRPSRESTSHITEFEEIEDDLARDDDQEGLVDESEEALRQTREKAASSPADKPRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTF0</accession>
    <name>A0A2T4BTF0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPCR, PTH11-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1405023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTF0"/>
    <dbReference type="STRING" id="983965.A0A2T4BTF0"/>
    <dbReference type="OrthoDB" id="5421689at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="41"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="393" mass="43119" checksum="F868E18BD16924D4" modified="2018-07-18" version="1">MATPEASPIVGSELPPINRYGAGIVALSVVMPLIATGWLALRVWTRRMRGISPFLAEDIFCYFGLFLFWAMGINGILMVVYGGLGNHLRELQPIQILRYSQILFANQVLYASALGFTKTSLALMLKRIFFTQSYSWVAYCVIALNVSWVIQTILTGILICQPVTMNWDPTARGHCGNQTLAFAAVSIVDIITDLAIMILPLQMVSKLHMKRTYKVALMGVFGLGFVTIIFTAVRLYLVFNVDFLDITYSAIPTTILGILQLGVANIVISAPLLRPVLDRTLGKWFSLSVVNGSRGTPAAGSRPSGMPKPGSAANLGLHTSIHGRPRAPGSKNFQRITESEENLRWEMDVMHSDKGRTTYVAWPDGSPESVMEMGTTPPAGKILKIQSTEVTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTI4</accession>
    <name>A0A2T4BTI4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_59808</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTI4"/>
    <dbReference type="STRING" id="983965.A0A2T4BTI4"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015747462" description="chitinase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="18">
        <location>
            <begin position="30"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB72608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="392" mass="41441" checksum="9428E858A21898B1" modified="2018-07-18" version="1">MPSLSSFTSTLGLLSLLPAARAGWNQNSNDNIVVYWGQNSGSVGQNRLSYYCQNAPDVDVINISFMVGINNLNLNLANVGDNCTAFPEAPNLLNCPQVAADITECQQTYGKTIMMSLFGSTYSESGFSSSSAAVSAAQEIWAMYGPVQSGNSTPRPFGNAVVDGFDFDLEDPIENNMEPFAAELRSLLDASTSKKFYLSAAPQCPYPDASDQSFLDGQVAFDWVNVQFYNNGCGVSHFPSDFNWATWDTWAKTVSANKNAKVLIGTPANVGGANAGSFPTDSQLSGAISLAKGSSSFGGVMLWDMAQLFTNQGYLAKIVADLGSSSSPPPPASTTLQTVTRSSTASTSPTNPPSGGSVPQWGQCGGDGYTGPTQCQAPYKCVVSSEWWASCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTU8</accession>
    <name>A0A2T4BTU8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1425375</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTU8"/>
    <dbReference type="STRING" id="983965.A0A2T4BTU8"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015730646" description="tyrosinase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB72741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="626" mass="69904" checksum="1DF68407253104D6" modified="2018-07-18" version="1">MGFLTDLAWAMTVVILLVSAQDYDFGVDVISLTRRRDTNAPILVGRLPSASNGSTPLRLEIRDVKADKYRWDLYVLALSMFQSVSQDDPLSYYQVAGIHGVPFVTWNGVGPAVGASQSGYCPHSSVLFPTWHRPYLALYEFFQQELHKLAGAIADMFSNATERSLYRQAASDFRIPYWDWASPAPEGQSHFPDVFWNATMIQYGPNGVQVIRNPLYSYSFHPLDGDALIWPPLRSWNETKRAPNTGVSQVEPPSMNDQVSAALLARLPEIQQRLYILFSSYHEFDSFSNKNYAASQNLSHLDSIEAVHDIIHIYGGSRGHMTYVPLSSFDPLFFLHHAMTDRLISMWQLLNPSAWMTPQISGETTYTALKGTMQNSSTPLTPFMSSADGTFWDSDMSRSTEVFGYAYGDTSYLPGDSESPRNKLIRKINRWLGLNSPAIVRIKSQAQQRRPSGEWKGSPGIKGFQPSLKADAIDVADDHYTEWIANVHVNHGALDGSFSIYFFAGKPPADVNTWAFAPNLMGSVGIFTMRGMGGHHSKMSGTVPLTMALMRLVDLGAIHSVDLNSAVAFLQSRLHFRIANIDNKEVDPSLIAGLFIGISSTRVRLPKSDVEFPEWGQPMLRLVLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU20</accession>
    <name>A0A2T4BU20_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 12">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1363072</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 12"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU20"/>
    <dbReference type="STRING" id="983965.A0A2T4BU20"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006215">
        <property type="entry name" value="Glyco_hydro_melibiase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00748">
        <property type="entry name" value="MELIBIASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015395001" description="Alpha-galactosidase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="14">
        <location>
            <begin position="339"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB72810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="496" mass="54937" checksum="0A5087585128263B" modified="2018-07-18" version="1">MLSKGALAVAVSAIVVEAIDNGLARTPQMGWNNWNSFGCDVSENLLLDHAQLINEYGLQDMGYQYVVLDDCWSDGRDSKGKLIADKKKFPRGMAAVADDLHSKGFLFGMYSSAGELTCARYAGSLDHEMDDAQSFADWGVDYLKYDNCYHMGRFGTPLISFERFNKMAEALKATGKNIFYSLCNWGEDYSYSWAASISNSWRVFGDIYDSFARPDDLCSCNDPANPACIAPGTHCSVLAIINRVVPYIDRGLPGGWNDLDMLEVGHGGMTEEEYKAHFTIWAALKAPLLLGTDLRKWSGSDLAIVTNPAVIAINQDPRGRAVQRIRRNFNVPKDEWGVGETHIWSGPLANGDQILVFLNFADEDLDMGATLAEIFLTNGVGGTAPQNKQDWAVHDLWGKTGAAMSNEDAQSILDADSASERRQKLQKLGWYNSTELSYAEGLKREDPRLFGERVGVIKSGGRFDVRVPRHAGKAFRLRSLSGEKIKQKSHLKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUH1</accession>
    <name>A0A2T4BUH1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1340432</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUH1"/>
    <dbReference type="STRING" id="983965.A0A2T4BUH1"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="301"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="673"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="714"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB72954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="873" mass="96288" checksum="BBA1A827BED67A9F" modified="2018-07-18" version="1">MDSFMLQDDGVRDRIRQAEEFLVPNDPHARSYRSDIILMLRKNQRRLTVNIDHVRDHNAEFAQEILQKPFDYTLAFNHALKEIVQTLPQARPDQTARDTVYYCAWAGNFGLNACNPRTLSSQHLNNMVSVEGIVTRCSLIRPKVVRSVHYNEAKDKFHFREYQDQTMTNGVTTSSVYPQEDDEGNPLTTEYGFCTYRDHQTISIQEMPERAPAGQLPRGVDVILDDDLVDSVKPGDRIQLVGIFRTLGNRNANHNSALFKTVVLANNVVLLSSKSNGGVATASITDTDIRNINKVAKKKDLLGLLSQSLAPSIYGHDYIKKAILLMLLGGVEKNLENGTHLRGDINILMVGDPSTAKSQLLRFVLNTAPLAIATTGRGSSGVGLTAAVTTDKETGERKLEAGAMVMADRGVVCIDEFDKMSDVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVIAAANPIFGQYDPHKDPHRNIALPDSLLSRFDLLFVVTDDIEDARDRQVSEHVLRMHRYRQAGTEEGAPVREQTSQSLGVSANTQTGSQRPTEVYEKYDAMLHAGVTRTSGRGASKKTEILSIAFMKKYIQYAKRIKPVLTQEASDRIADIYVGLRNDEIEGNQRRTSPLTVRTLETIIRLATAHAKSRLSSRVEERDAIAAESILRFALFKEIVEDSSRRKRRRTQAAGLVSSSDESGEDDSDEEGDEGSQQTTQVNGSSSRQSSSRMQTRSSRLNGTNGSTSQSSSRQTRAMEADMTLDSSSHPSHDMVDMQSSFASTLPASQVLSQTPGEVEDEGLASAASNLEIEDAAITPERLAAFRTNLGQLLNTSVFEDDSAPLDAVVRAVNERIGGREGGAFSRPEAIQALKKLEEANHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUJ6</accession>
    <name>A0A2T4BUJ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="17">Cytochrome P450</fullName>
                <ecNumber evidence="17">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="17">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1340110</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24 25">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17 18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="17"/>
    <dbReference type="EC" id="1.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A2T4BUJ6"/>
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    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
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        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
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        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
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        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
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    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
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    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 17" id="KW-0288">FMN</keyword>
    <keyword evidence="4 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="12 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="500"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="677"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001971"/>
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            <dbReference type="ARBA" id="ARBA00010018"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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        <source>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000240760"/>
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    </evidence>
    <sequence length="1066" mass="118274" checksum="4BAF3CDB782D8CB8" modified="2018-07-18" version="1">MAETVPIPEPPGLPLLGNLGEFSSNPISDIIRLADQYAGEIYRLHLGTRPAVFVSTQALVNECCDEKRFQKSLSSVLRIVREGVHDGLFTAHSDEPNWGKAHRILTPAFGPLPIRDMFDEMHDISSQLALKMARHGPHEPIAVSDEFTKLALDTIALCSMNYRFNSYYQEKMHPFVQAMSDFLAECSRRNRRPGFAPNFLYRAANEKFFNDIAIMRDTANAVVEARKKNPSDRKDLLGAMLNAVDPLTGEKLSDANITDQLITFLIAGHETTSGMMSFAFYHLLKNPDAYRKVQEEVDQVLGRGPAKVDHVSKLTYIQAVLRETLRVTAAIPAFSVEALEDTIIGGKYLVHKGEPISLVLAKSHLDPLVYGEDANEFKPERMLDAEFARLNRDFPNCWKPFGNGKRGCIGRGFAWNEAVIAMAILFQNFNFTLDDPNYQLEVAASLTIKPKDFYMRAQLRHGMTATELEQRLVGKGVPEEHRADKKAAAEGSSKGSQKPLAVYYGSNSGTCEALAQRVATDANSHGFKVTDLAPLDTAHQNLPKDRPVVIVTASYEGLPPSNATHFVNWIENLKGNELEGVSYAVFGCGHHDWVQTFHRIPKLVDSTLEQHGATRLIPLAATDAADSDMFSDFETWEDEALWPALKEKYGAAAGSSGGSAGGFIVDVTLPRKSTLRQDVEEAFVTDARSLTTSGPAKRHIEIRLPTGMTYRSGDYLAVLPFNPPDTVARVFRRFQLSWDAVLTIHSDQPTTLPTETPISANDVLRAYVELSQPATKRNISVLAESTEDEQLKAQLEKLAGDDYQQEIGLKRVSIIDLLERFPSLNLPLDSYLAMLPPMRVRQYSISSSPLADPAKLTLTYSVLEQPALSGQGSHFGVATHFLASLSPGDKLHVAVRQSKAFHLPSDAENTPLIFIGTGSGVAPFRGFVQERAAMIAAGRKIAPALLFYGCRSPGVDDLYAEEFERWEKLGAVEMRRAYSRAPEKSLGCKYVQHRMSHDREDVYRLWDQGAKVLVCGSRDVGKAVEAVCVQLVQERAAAKGTEVTEEKARAWWDKQRNERYVTDVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUW7</accession>
    <name>A0A2T4BUW7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1404825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PTB73097.1"/>
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            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="52" mass="5804" checksum="62643695435B7FB1" modified="2018-07-18" version="1">MPQYNETAHHIKEEGSRRGEIQRARSKSTKSSREGARVVPSSIRGLAQQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV45</accession>
    <name>A0A2T4BV45_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_347350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV45"/>
    <dbReference type="STRING" id="983965.A0A2T4BV45"/>
    <dbReference type="OrthoDB" id="4759875at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="278" mass="31043" checksum="75A9BF7ACA7A21C5" modified="2018-07-18" version="1">MTMTFAAGKTWTTVPRCWYHKAADNVPTTGRLYHHLAILARLNVIQQLYHYTKSSTTCYTPALLLQENGSTECLAAALLLHQVGLTECSPTTPLLHPDQLDQMPDSSPSTTPCSLGRGLAAAILIHTSGQPNALQQLLYYAMATKRFLTHRYRRLSREFVPESRPVAITRGSSPVYGFEQNGWQLMDSHCRCDSMWMHGFCFSFTFQCSAGTGSPHHTRIRGNADDTMRTPSTSVYCASSGLAAFFAMRWNSVMIDAWLRHTGFGSARMSPNQFYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVB3</accession>
    <name>A0A2T4BVB3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1433382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVB3"/>
    <dbReference type="STRING" id="983965.A0A2T4BVB3"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="349" mass="39627" checksum="2D6D90EC55638D26" modified="2018-07-18" version="1">MPSRKVRAPSPAPTSPSELSQARDSWSCSPDWDDPRDCGYWSKEDESVSMENVPEVIPGKYLRGTVIGQGGWSTVIKVKRVADGKLFAGKKSQTPEQLYKESKRLRKWEHPNIVKFMELYKQDSDEGNNLVIMELCAKGTLQMRIEWYFEPMGMFDIVSTIIQIADALVYMHGKGFFHADIKPRNIFIRRFDPMDVALGDCSDCKVHGKYEGPRTGTSDFWSPDMMAYNRHSGKSDDIWALGVTVLAMMQQKPQKDKTDAAKFQYPSRCANYAQELMRLNPGNALVDLISKMLIKNVRERPTAEKYLDMATKIMEGTSEDEKMSGSVDGLGLTSPEKYRPVEAPPVYHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVT1</accession>
    <name>A0A2T4BVT1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1441051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVT1"/>
    <dbReference type="STRING" id="983965.A0A2T4BVT1"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="399" mass="44026" checksum="93C95869EFA4B930" modified="2018-07-18" version="1">MQPAQALIGANWTPAYEATFFRSLCESVQLGMRENSSFKAEAWERAMLALQEHHGAYPAKSHLINKSDNARKRFRLWRGLREDPDFVYNPVTRTVTATEEAWRAHIEREPLSRALRGRPFDHEEYMEVLYPDVVGSGGAPKRIMKPRRKTDGQPCDETEMPGTGVLNLQTEPPPPLVQEPSEGSSQQPPPPQPQPPPHKGSLTQAPTAPSSAAGVQPRPTTAPSIPRNLTIGQGSALTPPDESVPQSRKRPSPMGRQSSGDLAPSAAVPVLAQSALPTSPEKRRRLSSRDDSNASISTPTPLLGSSALSRPALEARSRSETQSAGLQTIIEELSKTSRARMWKEEAVDILFKEFANEDADLQIHVSENVLSDEHKAMVFCKMPLHLRQHWVRKHRGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWK1</accession>
    <name>A0A2T4BWK1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1338495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWK1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWK1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="313" mass="34105" checksum="2F858EF2389CEC56" modified="2018-07-18" version="1">MADAQASSGTWSAFLKSIASFNGDLSSLTAPPFILSSQSLTEFSSYWATHPPLLTAAAAEPDAARRAMLVLKWFLSTLKHQYASRSEQYGNEKKPLNPFLGELFLGTWTDEAGTTTLVSEQVSHHPPATAYCVRNDKTGVQLEGYNAQKATFKSTIIVKQIGHAVLTVPVGSGDDKKLERYLITLPSLHIEGLIFGAPFVELDGSSLITSSSGYTAKVDYSGKGWLSGKKNTVRNLRTKESAEGQPWERRYFNAVAEDETLALLGKAAGIPLDGERDKTGGLWRFDAEKAAKADAEKLTEEQIARIEKEMLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXU7</accession>
    <name>A0A2T4BXU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1393863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXU7"/>
    <dbReference type="STRING" id="983965.A0A2T4BXU7"/>
    <dbReference type="OrthoDB" id="5296155at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="138" mass="15408" checksum="0F1F118B8726CDCB" modified="2018-07-18" version="1">MSYSTHSLKFHTRVDSRVSLTSVGRMPVIAEDSSAIITQPSPPPAALLRPSAMNPQRSITSLPRGPPRPYIVGFMDIPAECKDEGNDDEDEETVVGEKMSKLRRRKVMTAVTEACSVRWNIDVRYDTWKLHLQDGPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY19</accession>
    <name>A0A2T4BY19_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1403593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY19"/>
    <dbReference type="STRING" id="983965.A0A2T4BY19"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="7">
        <location>
            <begin position="532"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="607" mass="67618" checksum="F74D44370BA99669" modified="2018-07-18" version="1">MAKKRKASRAGESSGPKELDPADARLKVTSYEDVANSEDEFFMNRDTIMLDDEPNRKRPRKGEEEIEFSDEEVLGYESDSAAKPKPSKSKRKAADYSEDEEDKAEGAEDEDSNWWGSSKKEYYNADNIETEADALEEETEAKRLQQKKLAKMAEEDFIFDGDEWLTGEQEAEESAEPVTEVLKEVEITDDMGPEERLKLLSARYPEFDYLVKDFQELQPQLEVFRAEAKASDVKSLAAIKYWVLGCYVASLASYLAILTSPARDAAKARKTIDPAELRDHDVMETLVQCREAWERVKDMKSTSTANDASLLQGLDAIAQLESEALAAQTKAKKAKKSKESAASAASKAKKLAKAKAIEETVADLYDLPINTKSKSKSKDKAQRAQDDDSSDFGEEETMDARAAADKAARKKSLKFYTSQIVQKANRRAGAGRDAGGDMDIPHRERLRDRQARLLAEAEKRGKKDSKLGANLGDDSDEEDSKAANAIRDDEDEYYDMVAHGAKAKKEDKAARFAAYAAASKADRVVPTEEIGEDGKRKITYAIQKNKGLAPKRSKDVRNPRVKRRKQFEAKQKKLKSIKPVWQGGEPKGGYQGETSGINATVIKSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYA6</accession>
    <name>A0A2T4BYA6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1044155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYA6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="181" mass="20286" checksum="D0AA0190D930706A" modified="2018-07-18" version="1">MHRNRTNATHHKLDKLGSLHALTHRQRLGKGKVFLAWLAWPAWPRGRGAAKQTLQPIMARRIVSNWLFCKLLHATTYKSRPALDGRVALQLQKDSEAPQGWKPCDAAPSIEPRAKPQPICHAPSPQQPRFTLTAAIQQANSIQAFSGCPTCIHLIHDKHCLARGPSAVKVDEAWTQSYRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYR4</accession>
    <name>A0A2T4BYR4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1440610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYR4"/>
    <dbReference type="STRING" id="983965.A0A2T4BYR4"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="98"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="521" mass="59996" checksum="DB206FD98D3B6506" modified="2018-07-18" version="1">MGLLNERRGSDAGTDSSDSSTGTATGAGLATVPLHTDTRFQLGILSPSADTLKAPLGFLRSTPWRVLAVRFLIFLTPSFLQGRHAREQICPAKLSPTAYLDGMRGLAALIVFFCHYFYQAFTIAEGWGCGETNYHILKLPFLRLWYQGPPAVCVFFIISGYALSYRPLKLIRNGAWSDFANTMSSLIFRRGIRLYLPTAVSTFMIICLLRIGAYEWTRDFANDRKYMKNIVEPHPARMEHAYAQYKDWLIHMFRFIQVFSWDKFGGSTSYDVHLWTIPVEFRCSLYLFLTIIGTARLRTTVRWLTVAFVMAITYRNSRWELLLFFCGMLIAENDHIRGAHVSTPNPALPIEEKSRPAKAKFWPIFWALFSILGLYLMCQPDGRGEITPGWIWLSSLIPKWWKEERYRYWQSTGAVIFIVAVSHSPRWQRFFNLPVVQYFGKISYAIYLMHGPAMHVVGYHFEKWAYGITGVEGYWYNAGFVLGACFCIPTVVWWADVFWRAIDIPTVKFAKWFESKVVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYZ9</accession>
    <name>A0A2T4BYZ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_56675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYZ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYZ9"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="9373" checksum="49D85CF7EA531CB2" modified="2018-07-18" version="1" fragment="single">GSYMNIRKRYSEFDDFRQKLTASFPNFKAAVPELPPKSAIFKFRPKFLEKRRAGLQYFLNCIMLNPEFSGSPVLKDFLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ39</accession>
    <name>A0A2T4BZ39_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1440055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ39"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ39"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="527" mass="58301" checksum="5E7E366D0E3319BD" modified="2018-07-18" version="1">MSSKSSAEATKGCRSCMRRRIRCDLGRPACAKCIKKGLTCPGYGRHLRWADGVAVRGKLKGQRLPVAGPVPMEMSLSTIDDPVDAPKPSTAGTAAAPIPAPATTPISTTAPVPDAAPGPIPAVDPSTDTSRALQVARPTSISIKSMEDTPAAQGLLLNYTQWASSPEIIEYYDKYLAGRMVWVDSEENDYRRRMLPMAANAPGLRFAIAAFSLYHGPMKFPSELARYHEEARDACLDVVREQLREMNNRLNSGAELNTRDDVANAEWVLACILVIANYEMAKINSEAAESHRLAARTIVNVFGKNEACNKGLFAFLRNQLAIHDVLGSATSFDLVDVAEAVLPTANSGDHVLFSEYLTFLHQITLASRRSMAVDEAIDVSLWPESFTISELQMDPPVVRRDFIRLVDLYHHAAVVYAYRCLGYATPDNFDWLASVAKLFDQLDKIENFSLCIQNLPWPIFIAGTECHGDVERQHKVTEILDKTIRTTGFKQYETIRSFFNAFWNGPEPNWLPVAQQLQANGLRILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZH5</accession>
    <name>A0A2T4BZH5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1336971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZH5"/>
    <dbReference type="OrthoDB" id="4775599at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="16783" checksum="E73A03CDE482F84A" modified="2018-07-18" version="1">MNSGQPTSTRPLTYVIIPLLALFVICSAGLFFHVRRRRRRLIAAYSAIWGRGRWVTRDGTLVFVPRHSGSRRSPWGGLHSQEGLNELGEAPPPYKFKPGEDGGGGGGGGGGGGAPTTATELRDMEEGRRPPEYNVAENVSVAEPAAAVVAESRRMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZJ4</accession>
    <name>A0A2T4BZJ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1337137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZJ4"/>
    <dbReference type="STRING" id="983965.A0A2T4BZJ4"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="81"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="477" mass="53323" checksum="D92A237D96D4F04F" modified="2018-07-18" version="1">MAAGRDDSPERKAPSELDPSTASPQRIGLRSGLAALREKANIQDRLVEKLLQQVIPAEDRHGPEITITADDAAAFPQRPGFNLTTMSNNFRRFNARIGVVFKFQARMTRILSWRKPSHTLSLLATYTFVCLDPYLLCVLPVVGILLGAFIPGFLARHPAPPKGTLSSEQSMGYSPRGPPLAPAATVRPAKELSKDFFRNMGDLQNCMDDFTQGHDMVVALLVPISNFSNEALSSAVFLFLFAAGVFLSVAAHMIPWRLVFLAGGWAAVGSGHPAVARLLAATREEHIQPREREARSWLDAWIATDVILDSAPETREVEIFELQRQSAAGEWEPWLFCPSPYDPLSHPRIAGERPRGTRFFEDVMPPDGWEWSEKKWALDLWSRDWVEERIITGVEVETEGERWVYDIYNEREGRTGVVDDHGNENQSDASSKPSGQSGGMPHMSWEEGEDGTGKKGEWRRRRWVRLVKRKVAVAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C025</accession>
    <name>A0A2T4C025_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1037585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C025"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="74" mass="8416" checksum="8A843976A5563187" modified="2018-07-18" version="1">MPASTAKRRRKYVTPNNQKRGGGVWTLDLLEAQTPRFSSMSPALPANVAITLLAGLIWTAVKRHWRRLCHRCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C061</accession>
    <name>A0A2T4C061_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1432261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C061"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34441" checksum="400B6789CBE3EA86" modified="2018-07-18" version="1">MGKGGRIACIAVPYLWTIGALIALIFVGLGSTDEDSSTLNKLYFMRADLSNVTHVEATRFGDRLLNVTYTHMRNATEELAKALEEAEEDSELRDFYNVGLFGYCTGDKEGDKFVVDFCSKPKGSFWFNPLEVWHLNISGVPDLLPSHLQSELKAYQKVSHWMFVAYVLAFATTCIQLLVGFSAIFSRIGSLFTTLVAVVASVFMLAANITATALFVTLTGVFNSSLKEYGVTAHLGGNLLAASWLAVALSMASAVLWLFSSCCCSGRTEARRASPKGNYEKVDPAGGSSPQHNGHTTAPAPTFDKTNTAYEPYRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0A1</accession>
    <name>A0A2T4C0A1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1357767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0A1"/>
    <dbReference type="OrthoDB" id="4624666at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="75" mass="8089" checksum="B006955809BF7A68" modified="2018-07-18" version="1">MPSASERAKAKLDAVLNDPGRHDCSHRSNRIATTRYATGCGVVNAVPRRPSQSSVESANGGVRNRLKRLLSLPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0P9</accession>
    <name>A0A2T4C0P9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_336903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0P9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="20814" checksum="9087C1F6D0EF4441" modified="2018-07-18" version="1">MLGSVSHEDEQLPSNYPVYTSGCAGRFWSHNSRQPSHGHGSNAVPKEDSPSASPEANLTPLKTQTVNEAIQDSYRPSTLDEVSAPSAVDRNASSNRPKKPRLRSQQLHTSVIHRSAQQKDIQEPVIHPAKSVSPLCRWLPLTSSTALFYLQQLLDNIGICLASCTHVDRRGGGKECRRLCGLLVHFRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C107</accession>
    <name>A0A2T4C107_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1271627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C107"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="161" mass="17544" checksum="C14B959FF0642ACF" modified="2018-07-18" version="1">MAGVAALSSIWPIQHATPSIRVVCIVSKQLIPPVIISRPSPRHCKLSALMLQVIRVRRAQLQSQATMPQAEPNPIPKLPPLYPNSMQASSTEPNMPFFPLTESFVTAQPPHQKARHGKGMEDEQKRGQLRCMHQPVPAPAPAPAPAVSDPSLVPLSRLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C155</accession>
    <name>A0A2T4C155_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine pyrophosphokinase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1358207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C155"/>
    <dbReference type="STRING" id="983965.A0A2T4C155"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF11">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="325" mass="35826" checksum="5DD26B3D93765F93" modified="2018-07-18" version="1">MATPTTRPSSGLLDLITVFDNLPLDFEQNCHPYYRLLLAPDARTHGYIHPDTLARMPWPSSFTIHHHPQREVVLSPPPSGTSLSAHANAAFQQAVDAAIASNAFPQLNGMHSEPFLLVGARDFIQIERFAASLFGIGTRGAHLTAYSYDKDKDGGNELRIWVARRSKTLYTYPGMLDSTVAGGVKATDSPLSCILAESMEEASLPATLVGPRVRSTGVITMANRNPRSGLVHSEMLYTYDLELSGEGDDEVPRLGDDGEVDEFVPMSCGEVVRRMRAGEFKTNVCAVMIDFLIRHGRVTPETEPDYVEICTRLRRRLPVPTRSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1C0</accession>
    <name>A0A2T4C1C0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1471088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1C0"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="191" mass="21339" checksum="79802B6F58D7AF3C" modified="2018-07-18" version="1">MENIAITRFSPSHHTPLIPAIIQLHIDCIQFDGALLRFHPPFTPEKRRKMETFWNERLSQVSSGRRIVLIALASSADGNDHGGDVAGIVELGMPDADTGPFRGNLEMLMVSPRYRRRGLAARLISDLEEIAREEKRTLLQLSTDVGSTAEKYVYPRLGYTLMGTVPKYGISPLDGSLKDGAFFYKHLAELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1T0</accession>
    <name>A0A2T4C1T0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1402072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1T0"/>
    <dbReference type="STRING" id="983965.A0A2T4C1T0"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="167" mass="18095" checksum="EEF0EAA6FDB83F2A" modified="2018-07-18" version="1">MMICSSCRSALRLRLFASVPRPSSTAIAPIANLIKTSTTTTLPQRIRFLSSTTPRQFSSSSAKHSPESSSNEQRNDQNVYAAADMTEAEASIAAILASKLEPTSLLVQDISGGCGSMYAIDITSPAFRGLNMLKQQRLVNAALGDLVKQWHGVQIRTRVPPEDESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C237</accession>
    <name>A0A2T4C237_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1357020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C237"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="271"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1333" mass="151159" checksum="289832BBCAB1C405" modified="2018-07-18" version="1">MAPTAAGGPMSPEQKAITEAKSLFLQLNGGGQLFKDCVSQATSVSHLVQYVEDENRKHARKSSSRLLEKFQRNTEGLQSLSSVIELAVQAKADCLCPLWAPVKFILQISKSHSLVVHNITAMVQVLTENLSRIELYQNLQNNPDLQTELLRIFNDVTSFCVKALVFFQRRTFVWKLAISPPKKNFQNSVDQLKSHMQGVHNTAVAIELAKQHEYRREQDRLAIINRLGATNVREVHQRKVEAKAPNTCEWILSHPTFVAWEEESSQEASERFLFISGKSGCGKSILASSIIDTFDRQKKRTMYFYFSGLESSRQDADSLVRWFLLDVLPSTTEETVQTIKLLFAKGEPTSSELRGALSSVMATLPTPLYLVIDGIDEIQGPVDDLFVQLRDIIDKFPRTKAVFLGRPHAFEGQASAYWIRISNDLLQADIRTFITTETQKSALLQQPNVHERVIKELLGKADGMFLWARLSINELCGAYSQDDVKQILKRLPLGVENAFNRILQEIVNSSGETAIQRAKYILRILVASARSLELTELQHACAVATQMNQDEFEREPLDAYKGPDPATMFLRACRGLIVIENGKVGLVHLTAREYLTRPAMQWDSGISCFRIDAAGAHEFLADVCIKSITSKGFEWFHSREGFFVPQDLEYPPLFSYAFRFMAYHFNRMGDPEPETVARIQRFFNIHRASWFEMFMVSCFQDGHNAVTTQDFLETVEWMDEDSFNAMKKAEISKEQFKRTCQEHAGNNWQSQRLHLLNEVFGFLDETKATAPRSAVSPSTDNTPLGIRAPISPVQENLSQVVQLLADHATLSLPKQRDLISRFGQLLCKQGRMNNLLGPFELLFRLFKSKINSFPTTVLFGFAELCRSLERPQNAIEIFDIVLSRLDDEGESKYDVWERIGHAYSNLDDHERAFNSHHSAWTGRCKILGHRHLKTARSTFRMGLSRYQQDRLAEAEGYWRQCLAIKTAVFGLEHKETSLTICWLGHAILLQERFADAEDCFRQIAPLMEATSGKVHRAAADSLFWLGQSIFQQSRFAEAEIFFRRAAAKYWATLGPSRETAETISCVGDSLYYQHQFTKAEEQYRRSQQIIDQIKLSWDDGSKRRNPLRLGQTLCCQLKFSDAEDIFSSYFTASTGRDRVNFEGVLWLARVLHYQQKNVEAERVLTILLPKVDGECDVGKMYSEAIVLLLGRVLNAQGRYGEAESILRQAVINEASGQGKSARTGVGIGSGLRQIMEDNEGNDKLMNLEPLKEHQKGEGRGEGEEEGEEEVDAPIESEVDAKPGEDCWFSGLWVYCNTDDILSEYCATGHHLKRQGKVAEAEEVYQLLKSVGWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2I0</accession>
    <name>A0A2T4C2I0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_329153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2I0"/>
    <dbReference type="OrthoDB" id="10670548at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="207" mass="21988" checksum="15EA0544C3F5DFC8" modified="2018-07-18" version="1">MAGRLGGGRGPGQLCQHTHVSPTAGQPFSGCQHVGSIRVPRRISRVRLCGELIVLLLVASASRGDSTHARLRPRSEVAELDRTELASAMRPEPTQEDVGGSRQTRACRSAWHGWIQVSSILGPSLGAIGSSRCSSGRGRLAEDASGSPMRKNRRLFVTGIVLFAPVGVLRTQLYVSLVRAGLEAKSPGLRSSTTAATVTMTTMSMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2J1</accession>
    <name>A0A2T4C2J1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1422889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2J1"/>
    <dbReference type="STRING" id="983965.A0A2T4C2J1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB75787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="19867" checksum="6F3F1ACCF2DC5439" modified="2018-07-18" version="1" fragment="single">FWTTAERNTAVASIDSFLLTANWPSYAIAHSAAFAECLLVSVFFPDRRWAPLGSGNVLLCVGLALVVVGQVVRSLAMLHAGASFNHHIQTKKAQTHLLVTTGIYGWLRHPSYFGFFWWGLGTQLVLGNVVCFVAYAAVLYTFFSGRIEIEEHKLVEFFGEDYVNYRKRVGTMIPFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Q0</accession>
    <name>A0A2T4C2Q0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1260971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Q0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="177" mass="19646" checksum="4820DC3C35BC7311" modified="2018-07-18" version="1">MSFYRRGSHVRDGHDLTESYISIGYYLGSYETSNVTSKSNRTLISANIAGCCCCGQGERRQMMLPSVAFRAKRKRARNRPLVQFAYIHSNGLCGSLPAWAVCLVRNLGESRSARQGGHSRRVFAGERRRRTMASSYMYRLASAVTGEGWITRQDVHNACNVPCSKGGHTHTVHTLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2U3</accession>
    <name>A0A2T4C2U3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1439508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2U3"/>
    <dbReference type="STRING" id="983965.A0A2T4C2U3"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="21376" checksum="7900933348476C2F" modified="2018-07-18" version="1">MALPLAGKHCAVVGATGIIGFSIAKAFAQQGAVLTLLARSAADARPRLEPQLRPYSLPGTADHDLGVPAAHRFIRLDVADRESIKALQTGTTVGPVDILVNCAGITQTSLLMRTSDEHLSDIVDTNLLATILVCKHAKMRPNGCIINVSSLMATKGGLGASAYAASKAGVIGFTRALCREMASRSIRVNALLPGWVNSSMWTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3C9</accession>
    <name>A0A2T4C3C9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Centromere protein Cenp-K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1355652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3C9"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB76034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37670" checksum="AC53CA95D7616AFD" modified="2018-07-18" version="1">MEDRPRSSSEAQAHATNIDHTLKELQRKVREYEAQLDELRSAEHPTPSTAAGQAQILKLAFEEVTNSEPFLPFPGSVLPALLALRKTHRTIEESKAFLASQAEATEREQRRLKDDEAALKDHQLLNEALKQRIETLRNEVDSGVTTRPEDEARKRIEGLRQKRLQYNKETSKLMKALNRFIDEHLAVMLAAEALGGPVVGEMMDIDADDLAAGFNAQGKLKKPKGEINRDKSQRRIDEIWGPSDGDGDGGGSGQGRKTKQKQGQQRDAASAAGAEMRQLTEDLLNRLVEAKGSSSDAYVKLPHETAAARFLIRSHVAQFHPRDATKIRLVDFGRELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3H3</accession>
    <name>A0A2T4C3H3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1333437</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3H3"/>
    <dbReference type="STRING" id="983965.A0A2T4C3H3"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="123"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="236"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="328" mass="36139" checksum="494DA698303FDE0D" modified="2018-07-18" version="1">MTTTVAAQPELALRAKSRTATMDAVEDIIYGSVAGIAGKYIEYPFDTVKVRLQSQPDHLPLRYTGPLDCFRQSIKSDGLRGLYRGISAPLFGAAAETSSLFLFESVGRELLYQAKVAPRDNELTLPLLWLTGAISGVFTSFVLTPIELVKCRIQAPALSEGAQVAQLRPLAVIREVYRHEGIRGFWHGQLGTLIREAGGCSAWFGAKETVTKAFYRLRLRSATSEAEQEAIRSKPLPLWQQAIAGASGGVSYNFLFFPADTIKSRMQTSPVGGAHQRRDFWSEGMAIWRHHGLRGLYRGCGITCARAAPSSAFIFIVYDGLKRHLPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3M0</accession>
    <name>A0A2T4C3M0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_362477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3M0"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015401983" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22163" checksum="411F99099CBFFCFD" modified="2018-07-18" version="1">MKLSALASGLVALAGLALAQDAATGTISKGPFPADLNGSNFTYPHPVHVFSFSSQQQKLQMAFMDVKPTCAPNGQTAVVLHGKNFCAPTWNATITALAGAGYRVVAPDQFIKNQGQIVDLVLTQPVAHYFGDVVSKTLLIVGDQDHVAIGGNWSPPEVAAKLGHFDVLGPQVCGEIPDCTLYQFPDLGHAPQLSAPEQFEKVVLDWLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Z9</accession>
    <name>A0A2T4C3Z9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1401724</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Z9"/>
    <dbReference type="STRING" id="983965.A0A2T4C3Z9"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB76272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="241" mass="26807" checksum="D72B91E2C778E9AC" modified="2018-07-18" version="1">MSDPMDIDDDTDLWTSPVKNVPPEARPRTPKTPRTPRTPKTPTANDHRSEPLDREAMLRKELEGVRSINQVIEGVIGTLQRTGGNMNSVNKTVSNASALLNTWTRILSQTEHNQRLILDPTWKGATNDLAEIEAEKLRKQEAEARRLAEEEERKEELRRRREEEEQRRQLTASGTARRARRGAVGLRAARGRSRMASLSSRITGSSRYHTASASSSSRGISGASGRGRGVGTTKSRYSGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4A5</accession>
    <name>A0A2T4C4A5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1463080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4A5"/>
    <dbReference type="STRING" id="983965.A0A2T4C4A5"/>
    <dbReference type="OrthoDB" id="3527108at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="473" mass="54274" checksum="CFE47FAFA94E15EA" modified="2018-07-18" version="1">MGCGHLANFGLSSQRWCREASPGWIAAQAGSFRLHHFTTDEEDGDDETRIAARKSRFYPRLKLAILLLGVAAAAILFVKLVDPSRVTSLTRQSFSYSDSIVPMFSSKKEPGATPVLGESFFDFGMYFPAQGNNFFPLVASYNEPPRHRPKTPLFIPFTRNNAMMRQTVLGYIASGWPREDIIIVDNSGTADANNLKLLSQSNPFFLDYDLFRYRYGVSILQTSVLLNFAQIQNFLIRVAMARHWPYFFWSHMDVGILSHEEETPYLSFYERVLKVLDEAETSRMSGESKWAVKFFNFDYLTLVNVEAWRHIGQWDVFIPYYATDCDAYGRLKMMGYKIDGVNAGHIWDVADLVDNPEEKFFPPSPTKKDDSTNATDDNAPNSERFKSLREELQKIQDEKLSNSKGRNTWQNMQKGGKGEPWTYDPEGFQVAWWEMAEDGRKLYKHKWGVSNCDLLAEKKTLDDMWSEAHKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4K6</accession>
    <name>A0A2T4C4K6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1422535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4K6"/>
    <dbReference type="STRING" id="983965.A0A2T4C4K6"/>
    <dbReference type="OrthoDB" id="5386093at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015557622" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="44872" checksum="B581FCC8AB27898A" modified="2018-07-18" version="1">MAVARRRPSPAVSLTALVLSSTFLPIAASHALPRETKTVAVRELNVVPWPIATPAPRASPDLSLAAVPAADLLRRDFNTICGFIGGHADFPATCLPGSHCAVDVDNKAIGCCPDGAPCTGGIFTSCVDVNSPPQTELNPYVFTCTGADVCYRNSFDGGFFQFGCGASSALATGVATTAFGRGPLDFSHVSVRLTATPTLLATPTTIGSRTGTRSSDDTSTSSRGTKTTDASDTKTASSGEATGTATDTSPTESSTSTSAPEPAAPTSSGSSKTGPIVGGVVGGLAGLALLLGLLFFFLRRKNGAKPAQYIDPSTEKYNNSEPQYPPKTPLLNEERGIHPEGAELTQLPRRPSEAAPQLGEIGLAVPFSPTSEYSRPSDEIPLRDTTPTPKPDIAAPVDMGPYIPRRRADGDGTFFSSQTRSESRTRGRPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4U7</accession>
    <name>A0A2T4C4U7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1400935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4U7"/>
    <dbReference type="STRING" id="983965.A0A2T4C4U7"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="52"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="524" mass="57308" checksum="0F681EE8555FBD0F" modified="2018-07-18" version="1">MAASYLRSTALPLGGLKRLAARPSAATAWLGARRTKASLAQDGQQQLLSAHLAKADPAVFDIIEREKNRQKHFINLIPSENFTSQAVLDALGSVMQNKYSEGYPGARYYGGNEFIDQSERLCQQRALEAFGLDPKSWGVNVQALSGAPANLYVYSALMDTHDRLMGLDLPHGGHLSHGYQTPTKKISAVSKYFETLPYQLDERTGYIDYDNLEKMASIYRPKIIVAGTSAYSRLIDYKRIREICDKVNAYMVADMAHISGLVAAKVLPGPFPFADIVTTTSHKSLRGPRGALIFFRKGVRRQNPKTKEEEMYNLEGPINNSVFPGHQGGPHNHTITALAVALKQTQTPEFQAYQSQVLANAKAFAKRLGEEKGKGGLGYSLVSGGTDNHLVLVDLKPHGIDGSRVERVLELVGVAANKNTVPGDRSALVPGGLRMGTPAMTTRGFHEDDFVRVADVVDRAVTIATRINKTVRAAAEERGEKSPGKLKLFVEHLGNGDGDPEIVQLRSEVADWVGTYPLPWDSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C530</accession>
    <name>A0A2T4C530_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_299960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C530"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="12576" checksum="3CCACE70970BB243" modified="2018-07-18" version="1">MRNLDPMSWHLRIFVEPIAQLHSSCCVSGNPCPHWTRRNQLFVCGSISLGHGLLRCLFSDGHGLSHRLLDLQIRAQEQTPVVHPSTNSTTPLQTTEQLRRWTKNVPRSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5G2</accession>
    <name>A0A2T4C5G2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5G2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5G2"/>
    <dbReference type="OrthoDB" id="5594612at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000075">
        <property type="entry name" value="Related to IVY1-phospholipid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="42766" checksum="C6FC970A7D3DF7F7" modified="2018-07-18" version="1" fragment="single">MATPSASRPSTPTPSQLPPMPESPVYSLASTALPLSQYNLPLPPPPRPSHAVITNADLERSQEAYAELLTSAKAYRVALAALSTAASTFGSALEACARLKEARSEPIGPAGAANMTASFTTKGQCTADTLMSASGVHHLIANHQQILSETVYRSFEVPLLHELDKWQTVISEEEETYQHNIKAQSREVKRLEKEGLKLHKQRRRDVARFRAHLVELTYKLDGLTSLHADHARTLLRESQETSARIVEASCSLVRAEVDIFESLARKGWSGGGLDDVLEKGQDLFAIEDDGSHGAGASGGEGVKLFSILPPKSILADTTSEQRSESLMMDGDRYQSLTAMASDPKPAGGDTESVFSADFNKPRNARPFSPQPIRRAPTDVTFDLLIGPASPNPQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Y6</accession>
    <name>A0A2T4C5Y6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1401286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Y6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Y6"/>
    <dbReference type="OrthoDB" id="9986966at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="203"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="311" mass="33340" checksum="326F835EF87FB7DD" modified="2018-07-18" version="1">MTEVTNRNEVRAANAAGGWTIVYGDLINEADVVELVISVPTGTVAGWVSEQVDAQVKKFNQSLATVSDDVVNEATQYLKGLLQGKRSGERDINGLGVKAGIVTYHRKLKTPFGSAPLPNNHQPYIGLRISKPLPPKGAPASVQIPPGVQPTAQSNGAPDGLDSRSWYRIMNPAKPGMAIDVVNDGNQQQDGQVQMAAEGNFSGQHWQLRPSRTQPGAYNLCNMWLGANKCLDVYGNDKTRPHLAAAGNYSGQQWRVERNGNGTWKLSNAYSGPLVLSADAAGGGLALKDPQTSPAMMWTLQPIKPITEVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C662</accession>
    <name>A0A2T4C662_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C662"/>
    <dbReference type="STRING" id="983965.A0A2T4C662"/>
    <dbReference type="OrthoDB" id="3946750at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="862" mass="96171" checksum="30085127D4256705" modified="2018-07-18" version="1">MLSTSQLASPRARLLLARNALHSNPTAAQQSRQFCGFDLGRRRHRVFTLKYLVSLNRRLPWETLKSGSHKAAASSAGSTGKYTNLKDVKSWSDDLSGARPGRSIEDVERDAINHLFHKDDNVWTPLQNIRDYMHSSLHQSDKVTAESVLRATTDDSLDFIDPITNRRVSRAERGRYSAIKVDDPNAPRKLTPEEESKQYTDLGDYKPSKWNEPDGLPQLTPEERSKRYGDLPEYAQMNIDNPNAPRKLTPEEESKNYDDLDKYTSVTWNEPNGLPQLTPEEKSKMYEDLDQYGPVTWNEPNGLQEKSLEEKSKDYKDLHKYGPVTYDEPDGLRRLTPEEKSKNYTDLHAYGGPFTCRESVLKDYEALQNDPTPKAEPIPAKVQVRDAATPQYDDLDKYGPVRWHEPDGLRPLTSEELSKDYEDLYMYSQYPNAGPKTARVHPEEASKAYRDLPEYSAFPNAGPKVERIHPEEASKKYKDLPGYAVDGFVEPAKTRHIHPEELTKNYADLGNYEPQSFESPEKPYPMHPEQASKAYKDLHGYNASSPDVDSQELPDVVAASLREYEAKEKLQADVAASGASHHLSAIEESERALESLTADDIRSQVLSRLHRAVQEEEEEAAMEMSSMDESFPSELSKSESEPIEGITRKLAEMRAEKDPYSNDPKGLETSYSEECGGEAAEPVAKHYEPAPPTATVTARLTDEPAQYKILAYDASTQSVSVAETTSDEADVSSPPKLTEVLLRLSHASKLAVANASDLPCNAPSNPTRVNPVDMMGQSVAGNFASPTGFVNYDSLEDSHVKPAPPVGSSQQTRRDEAERMRPASPEKKKRSFGKKVVMGTVWVGGAAYAVGALAEHFSAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C693</accession>
    <name>A0A2T4C693_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1470101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C693"/>
    <dbReference type="STRING" id="983965.A0A2T4C693"/>
    <dbReference type="OrthoDB" id="4158205at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015694005" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="42694" checksum="BD2331F4197672FB" modified="2018-07-18" version="1">MVSLKILSGLCLLQVQHVLAIDRVCLRWPYAELLPLKHYPPAESYCSHHYPLPPATVTRTVTQPTTAFVTVSKPARTVTITTRTATSTIYTTAIVATLPSTTTTATVTAFTTEQETVTVSSGTVTAYTTVDSGLTRRNQQKHHDFREDLLPRLAACRRDMLKTACSCIEVHPPTHTISATAKCTHTSYKTVCATKTVSVIGTVTTKNVSTSTISTASTTTTSILGVNTELEVKSDTTSIDSISTLSTVFVTEAPTAATTTASVTSFSEIDVAFTTTLPTTSMHTVIVPLATTTVSSTNTYSRVYGPVERMRLCIDGYSQDIPAGTPHTARAAICAAFCDRTPGCKTVGMNWFPACGANGESVYCIASADAWAGTGTMECGIGTGYNGCAIYQDGTVYEYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6A4</accession>
    <name>A0A2T4C6A4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1456765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6A4"/>
    <dbReference type="STRING" id="983965.A0A2T4C6A4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="219" mass="23765" checksum="FCC5BB5C84701C40" modified="2018-07-18" version="1">MAAIRVGGPPWLKALVGRADETTATVELDLMSSNLETTEVWNGRDLARCIGRGAVREVLVLYHGKGLPKNAVKRVMSFSEALTKGYLDSSSDSPQSFWQKARALLPSAYVGQSNKDCETDNRKISNDQQNEVIFVVNNRTESPNISHNRCNNIWKEGLSCACLSVLCQVGVIMYAAFTAYSRDKGVIDTYAFPLFAAGTILLSCGIGASAYVVGSSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6C1</accession>
    <name>A0A2T4C6C1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1332315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6C1"/>
    <dbReference type="OrthoDB" id="5325276at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="730" mass="80069" checksum="D8B5CE2F2B11DBC7" modified="2018-07-18" version="1">MGFLDFLTKRPSVDTTSSQKSQAMSSNARGVLASRQSGTRTPDPSQRLLKPRLVGISEGPSRIDSKGSESAKTESQLKAIEHSTSGSKAGLSLNSIPKYDDRERPHSRGVDRLTPLTPNFSLPRRRSSAFIDILDAQGELKSYDFKSRVQASGSRDYGEDVADRNIQPAVAGSTLVHGSRRCASTRSYSKHVYTVPVVPDWCKGSASKIEPADRPTSQQASLRDRPRSRGRLSPAAETFARTRGFSGHNIHDHRLQSKSSYGQISITGSPASTPQQAPRTADGRYMRDEDSSFPSELSASPPGIPRYKPRQYSLPSSELLSGAAPGSVRSARETLNKSLMPPHSDRSRQLYQQRCKTPTSPNQLHSFRYRVESDWSLFNRQAGEHLQPTVPHWDDAASSHSEYAPSFAFGSMGNLQLENTDRQPSVRTFGKRGSISSFAHSDYSSHHLSGSRSVGTADTSIDIPAHSLFNKMSFGGGSSRNLRSRGGDSYIAPEFTGKEDESCGESIFISPATPVEEQPFRNPLSPSHRGLSVSSYDATSISDSDVDSFRDKYPHTGRDGEALLFRDEGFGDTGKSLPGLFNDSDHLSTPKWPDTPMTPTDASEMGDDEASVLGMPLDLQKLRPGRSRPLTQRERLLALGYDYDSDSDTESSTRTDKLPEERALELISSLMKGTASAESRNGQHLDEKTIVKLRKDNKRRRMLEARKGGQFSSKENSETEATALGITIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6M9</accession>
    <name>A0A2T4C6M9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">M440DRAFT_1330667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77220.1"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="135"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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            <position position="150"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB77220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="420" mass="46749" checksum="F38A4241FBF68EE2" modified="2018-07-18" version="1">MVRHKKDFNARGKKFGPRGRGAPRQPRHHNDNDEHDGELSSSAGRPAFKAACWDLGHCDPKRCSGKKLMKLGMMRELHMGQRHGGVIITPNGKKVISPADRELMDQFGAAVVECSWARTKEVQWNKVGGKCERLLPYLVAANSVNYGKPWRLNCVEALAAAFYICGHPDWAAQILAPFSYGPSFLDINSSLLKRYAACEDEAGVKRTEEEWMERLEQEYAESREEGQDDMWTSGNTNRRAPVDSDEEEGEEDDSDEDEDSQEEGSIDGIYLGKRPPKQAEKGEDEEDEDKDPYALSDDSDDDDAMAEIRRKVLASKTFTNPNPDSAEDKQKPSTISRPQQRFKADLDIEPDSDNDAAGGSSDEDGGDASQGDDDDEFDNIIAATPVTDRIGLEKLKKERARAAITTRTFSSNVVSAPSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6N5</accession>
    <name>A0A2T4C6N5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF167-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1207186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="121" mass="12540" checksum="10A8994DB1591ED6" modified="2018-07-18" version="1">MAAPASAAVRFLAASKKAPQGILQLRLHVKPGASRNREGIQAVTEDAIELCVAAQAKDGEANQAVIEVLSEVLDIPKSKLVLAQGAKSRDKTVVVQDIKGDGASYANAILELLHKASSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Q8</accession>
    <name>A0A2T4C6Q8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1400154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C6Q8"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="16697" checksum="E6BA46DE0C1CA213" modified="2018-07-18" version="1">MDPSQQSSGSQSAPIPPGLTPELVAFASQMYDSARKGQIAVFEQALPAGLPPNLTNEKGDTLLMLAAYHGHADLVRLLIQHGADPNRLNDRGQSPLAGAVFKKEDAVIEALLEGGADPDYGNPTAMECVSMFKQEDTWKAKFEAAPGRGKAQPPSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6W6</accession>
    <name>A0A2T4C6W6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1330459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6W6"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="1">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="11348" checksum="565B7C537CE8B972" modified="2018-07-18" version="1">MTVAKASTCCRKGTDAECACAQKATCSCGKQSALHCTCASASSENAVNGPRCSCRARPAGQCTCDRAATENAPVSGSTCECGARPATACTCEKAADGGYNPANEVDFTNYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7N1</accession>
    <name>A0A2T4C7N1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1330954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7N1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7N1"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="286" mass="31924" checksum="2598D725C15A0BB8" modified="2018-07-18" version="1">MTQTQTENQLNRRIYRGSCHCGAFIYDIDLPELRTVVECDCSFCRRTCNLYVPTDEDANFRVVNVSEENLTSYTFGPGSKIHKFCPTCAMSMLSRLPNGPAHMRLVLNARALQNVAVYVLERKYIFNSRIGAQYQPPKHKGDMPCIVEGGQLYTGICHCGAVTIALSCEPLEELGEERVVVCNCHICRRNAYVWLFPKAENVILSGSEDDIGRYTFPEGLTSKTFCRACGVGMTYLINQPIEDRVLAPNETPCRAYRKGDTSHPVNERVLHGVEVGKVEGAAVMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7T9</accession>
    <name>A0A2T4C7T9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1421359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7T9"/>
    <dbReference type="STRING" id="983965.A0A2T4C7T9"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="251" mass="27395" checksum="1A0A3D0AE0C17E0E" modified="2018-07-18" version="1">MSIVLITGANRGIGFGIAQAVASRIPSSTIILGCRNIDNGHEAIERLRKLGVSSTLDAVQVDIEDIQSITAAVEALDNRYGKLDVLINNAASLKLPETQHLAELKDCSNSSFNSCVTSNALVTKAFVPLLRKSSWPRVIMNSSARGSLGRTANRELPPVALIDYCVCKAALNMLTLHYQILEDNHKDGGESINFWSVSPGHTRTAFNNYRGKKEPVASAEAFVRLLESDKGAIRPGTFWEFEDGKLQEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C898</accession>
    <name>A0A2T4C898_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1320862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C898"/>
    <dbReference type="OrthoDB" id="4897973at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="140" mass="14786" checksum="6F23EC0B30BA8056" modified="2018-07-18" version="1" fragment="single">MADEDGSNGLGFDDPSFGFIGGGPVSLDGISDAPLFGGDPSAGFDPGVWQLDGSPQANSYDLGSNTTLSSAQPGYLSPSWPTPTFDPRQNQSQQPQQQPQPSQQPQQQQPPPPPPQQQQQPDPSTFGLPNFDPTSVYFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9K5</accession>
    <name>A0A2T4C9K5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1389960</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9K5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9K5"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB78240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="569" mass="65402" checksum="F257DCD4F5BE3F65" modified="2018-07-18" version="1">MATRYSLRQTPRKKELFDGLVETPKRQTSRARQSSQAPESLDSQDSAESAPRERITRRRTAKFIENLDEEEEDLKPAANGHTNGHANGHANGHSNGAAPNGKDVVATTNGTSAGAKVVDGWLPGQDPKIDYSGEFEFGGSFGTATMMIFFPILMWYMWIGATFYDGKFPSRAPGQSWAEFGLHLVNLVYTHGFPHAKAWLWYWSYLVFEGACYCLLPGVWGKGKPLPHEGGKQLDYFCNAYVSLYTTLAVLAGLHFSGIWPIYTALDEFGPLLSVAICSGFLVSFVAYFSALWRGKQHRMTGYPVYDFFMGAELNPRMFGILDFKMFFEVRMPWYILLILSLGAAARQYEQYGYVSGEVMFLVMAHYLYANACAKGEELIITTWDMYYEKWGFMLIFWNLAGVPLSYCHCTLYLANHDPATYRWNRWALAAMYVCYLFWYWVWDSCNSQKNRFRAMEKGNLIPRKTFPQVPWQTLKNPKTIQSPQGTILVDGWYGLARKIHYTSDLWFSLSWGLITGFKSPFPWFYPVFFACMIAHRAHRDITRCRAKYGEAWLEYERQVPYLFIPYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9U1</accession>
    <name>A0A2T4C9U1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9U1"/>
    <dbReference type="STRING" id="983965.A0A2T4C9U1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="94"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="184" mass="19938" checksum="E56A1163ECB99E58" modified="2018-07-18" version="1">MTSSTEPDPTPASTGLPPLRRVITEHDAHGKPIINRTLSQHIPNISPAGMTFSLGYSLNESPAILDNDQDLRAYQERLPHNVGLSIRGGTVLRIVDFLPGAEAPMHRTATVDFGVMVEGEVQLIMGSGETTVLRRGDIVVQRGTLHAWKNNSATEPARGFFVLVDAELPTVNGTKLDEVIPNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA75</accession>
    <name>A0A2T4CA75_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1328559</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA75"/>
    <dbReference type="STRING" id="983965.A0A2T4CA75"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="117" mass="13463" checksum="A0F2B8D1F1CB2DE2" modified="2018-07-18" version="1">MADPKIQELLTKSRSELTEYEIAQLEEYEFSSGPLSILQTAVRSHTQVLISIRSNRKLLARVKAFDRHCNMVLENVKEMWTETPRLADGKKGRPVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAQ6</accession>
    <name>A0A2T4CAQ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1352179</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAQ6"/>
    <dbReference type="STRING" id="983965.A0A2T4CAQ6"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB78602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="245" mass="27060" checksum="CEA085BB1C0BD17F" modified="2018-07-18" version="1">MMSSTNEEDPFLQVQQDVLSQISSIRPLFASYLRIRSLASSSTSPELTSARAELETALSSLAEDLADLVASVQAIESNPSQFGISDHEASRRKRLVQEVGAEIQDMREELNKNIAAAAAGKGGEQLPDPSSFAIGEGDGGGDAYSEFEQQQQVEMMHEQDRHLDGVFHTVGNLRRQAHDMGRELEEQNEMLEVVDDLADRVGNRLQTGMAKLQYVMRKNEDRLSSCCIAVLIFVLILLLVLLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAT0</accession>
    <name>A0A2T4CAT0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1429565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAT0"/>
    <dbReference type="STRING" id="983965.A0A2T4CAT0"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="54"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="661" mass="74686" checksum="C26E4C3A8708A560" modified="2018-07-18" version="1">MLSLRPRAVSGLRQAQPRLALPSGWICPGCRTGFAAVRRWNSSQRPAGSGEKPYYITTPIFYVNAAPHIGHLYTMVLADVVKRWQQIKGKEAYLCTGTDEHGMKIQRAASKHGMDPKEFCDGNSVKFRELAAAANISNDFFIRTTDQEHKDAVSQFWLHLKHATPESLGLYKGVHEGWYCVSDECFYPEDLVQPSIAPQTGRKIMVSTETDNEVEWVKEETWFFPLTKYKDALLKLYDENPDWIKPAHRMAEARDWIENHLEDLSVTRPASRLSWGIPDPEDHSQTIYVWVDALINYITKAGYGSKWHSAKDDMGLWPADLQVIGKDILRFHTIYWPALLMALGLPVSKGFLCHNHWTMSNRKMSKSLGNVVNPFFAIQRWGIDPLRYFLMRNASLNKDMSYSNQQIGAVYVKELQANIGNLFYRIAKPKASVRWSTLEAVAAYRNGEFDAWAENNAASDVDATYSSLEGHLAESPAAICREMDDYNTSGAIREIFELLRETNRYVTDCKPWDLVKLQGAESRTLLNWVIFNCAEALRIAGILLQPIMPTKASELLDALGVQSDRRTVDFAAKGKDADYGTESKPVEPAPRMSKWDTLFPPTPSAELSDDELTEHLRVALLDKTRNKMNQMAELLAMEARMGEEAVAKLLADVHAAKTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAU5</accession>
    <name>A0A2T4CAU5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1319307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAU5"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="168" mass="18308" checksum="3BC8BDBB99DFDAEA" modified="2018-07-18" version="1" fragment="single">MGNAAAFDNCPKHKTKLSGLIDLWDEKAYFTPDVVAQLRTALANGSAEITAVNLELSETSLKLAKDAPYILPSFHGDASIPWYDLPAGTWLPHITPNSSRPMVPDQIRPIQLAAGPADKRVVDAVKTLLKDADYIYSKGNEPSDDVHIGYSEMGERIFLDEITGEVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBJ9</accession>
    <name>A0A2T4CBJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1156516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CBJ9"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015481164" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="126" mass="13051" checksum="1B4E9AD6A6DE4826" modified="2018-07-18" version="1">MVSFTITALSAIAMALTTSAAPAEPNARASINRTGSITWYNTGLGACGQTNNDGELVAAVSASLYDREHPCGRKIRISYQGRSEVVTVVDRCAGCAENDLDLSPAAFKGVIGDPGLGGISASWDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBK9</accession>
    <name>A0A2T4CBK9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PPR-type GPCR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1436363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBK9"/>
    <dbReference type="STRING" id="983965.A0A2T4CBK9"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="326" mass="36347" checksum="FEFDFF30BF463DA7" modified="2018-07-18" version="1">MSPNPPPPSSSSSSSSILRNRRASLSSNLLSTAIQAEHALEQKLSSLLSWDDLPAWRRDNAFILTGYRPIIPSYAASARSLLYLHNESVNIWSHLSGAIIAILTAIYLYLVIRPRYESATSSDVFVFACFLGSAVVCLGMSATYHALTDHSPEVARWGNKLDYTGIVALIVGSYVPALYYGFFCHPVLMAEYLNLICLLGIGCVVVSWVEKFRTPAWRPYRALMFVSLGLSGVVPVCHGLLKFGYQTLEDRMSLSWVVLHGLMYIFGAFLYAARWPERSYPGAFDIWGHSHQIFHMFVVLAAATHFYGMAKAFDYHHQNKASLCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBR3</accession>
    <name>A0A2T4CBR3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1326910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBR3"/>
    <dbReference type="STRING" id="983965.A0A2T4CBR3"/>
    <dbReference type="OrthoDB" id="5293596at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="38284" checksum="70A79FE7D4F59FCD" modified="2018-07-18" version="1">MDTTPLLGNRPALIQDHPVFLRASHSPWSLIPQNVLSFVRGSILAYLTVAAVLVLNYELTNPPPNSNPSDLGDSDPSDPGSDPNDPNLSALASTATNWRLLFDFPIISFGLVLWYFVVTFSWTFTHLYFPDADDIDGGVEYAIIRLMSLPRDLGNARYQFYFTLFYFTTCAYSFMNSAIYWFVTRPHDLVHAVLRLFSQGYPEVVKLWDATAVTLAGPFSDIFGEGWLRAFVLINLYAVTPGIMVTEVLFLNSIRRPNGIGGYLFALLVFAALYIGWAFIGHAATGVWPFFFLDAAQVGSTEAVVADSIGFVLLAPIAFVFMQGFVGVRESLIRPYVIVQDALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC93</accession>
    <name>A0A2T4CC93_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1428596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC93"/>
    <dbReference type="STRING" id="983965.A0A2T4CC93"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015487272" evidence="2">
        <location>
            <begin position="29"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="781" mass="86151" checksum="3B9CB255959EC6C3" modified="2018-07-18" version="1">MASFSPSRGTWLLVFCICLVLLPSPVAAFGAGNIPSIAQVEGHNWRHGDIEDMLSGIAFLHGKKWTSMLIKRTYFGNWLRDYSQAVDVGSLKGVNAPTIRILVWVLSFMSFGYATEEFEVTEERLGCYRPEEHIDNPKGYADGIDARTLDPRLRGPVDPIEIDIDLNTGMKNYIANETGRWATSAGYLRYSFARSIHFGRLYTSGPQRGNEADLCEALRCLGQALHCMEDFSAHSNYCELALRELGHRDVFPHCGAQSEITVRGKRIFPLVTGTFGGVDFLHSVIGEANDHFTQSEVDEVDIALLNAGAGTKSGGGGASRGLLDIVAPKDFISLIAKIPGDGSGFAAQARELKAMSEAQERENETRSRAGGNANVVPGMSPNFDPVKTARQIYPILQFRDRIVKAISRGIEKVPGLEKLLEHISETLTAFILGLLAPFIRPIINQVSKVLKDGSSGVISASANSQFEPWENPRSSDPTHSMLSKDHFTNVLNPCAGRIAATILQYTVPRVLYAWENPSVPVDEVVNDVLRAFHHPALRNDHVQIQRDMFRTVQDWVNEHPRRHEIDRLLSSESVKHGKNHILNQKKKGGVSGHAHDAWDTVTQLGHGKVSGSLWEQVKTRDLNSMEGHDGNPALNYTSSSPAPPSRYSPPAHGGYGYGESASYVSQSQAESSHGQSGHASSYYQGHHNQPQQPSQGYGSHQPQYQQPQYGQPSYQQSQYGQPSYQQPQYGSEGQWAQGQQPHGYGGPAQPQYASHQGHHQQSPSYGSQYHGSQHHEHRHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD74</accession>
    <name>A0A2T4CD74_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_239883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD74"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="122" mass="14117" checksum="245A4758F3773B56" modified="2018-07-18" version="1">MFAAERCKESRKRYQRMFSRGRKKTWWGGRDDERSDANRAVPALEEERSEASSSSCVLLLFVFPLELEVEERKEEEEEIQEEGARLAVEEGRGEEAAQLLAQALRTRRTRSSPKNVPVSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDA0</accession>
    <name>A0A2T4CDA0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1419886</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDA0"/>
    <dbReference type="STRING" id="983965.A0A2T4CDA0"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="203"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="440" mass="49104" checksum="713B5DCB8D8F8D3A" modified="2018-07-18" version="1">MPSPIDDSLNARISPDCPQDTRDVLHHAWAHDLSGLKKLLVDRSKASVQDPKTGETPLHAAIRACGPASEPDKDAAEEEGKDEEEEGEDGCVEEAREVVQALFFSGAIWNDVDANNETPGCVAYRLGRKTLYNMCVDAGVRAEILFALMDGYEELSSGEDEDEDDEAVEQEDAAAAEAGEDKEEETAKDPETTAFVPPEIDEKPVTSKEYLESDLTYDANKLLDADLNGVMMSWETDIMRRSVAALLPESPPGKRVLNVGFGMGIIDGMFADLKPSRHHIIEAHPDVLAHIDSPGCAFGRAWEQSAPEEGEYRVCRGRWQDVVPQLAEQGYLYDAIYFDTFGEDYSQLRTFIMEWVPALLDQGGRFSFFNGLGADRRVCYDVYSRVVEMHCADAGLDVEWEESDVDMAELDKDGQGEWEGVRRRYWTLDKYRLPICTFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDS3</accession>
    <name>A0A2T4CDS3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1436921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDS3"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33705" checksum="4AF312F21AD11386" modified="2018-07-18" version="1">MGARTGFGLKFVQWFIRGIQFCCAAIVLAIYSYFLATLHNHHLPIATSLRAVEGISGAGVLYTLLALLTLCCLAGHTLVAFLAVVLDVCFIGAFVYVAVANKNGAGACDGVLDTPFGKGQSDATVKAHSGFTKLPSFHTACRLQTACLAVSIIAIFFFILSILMEVALARHHRKEKRFGPSPQNDYTSGFGRRTSTRNTGFFGRLLGGRKVVDASEEGNMLPQHPQPDQLNHPHAGGDNEMSANPYVHTDYNGKYESGYGYSGVTGPNGTTTTTANNNTTAYTGAGGYAAPQGTAGYGQPVNYRYDDGIYDHAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEX1</accession>
    <name>A0A2T4CEX1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1111759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEX1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="17453" checksum="BC28D74B1EBA4C20" modified="2018-07-18" version="1">MQGGGRVEYCLQYMQQTEAADRTASQGSRQEKRHAGDISLRRHRRMCAVAASEEERKSDDDRRPERAKSPDRVASGMNALPTPLSFLSHSANVDMVLLDSCVLRPGRAGVHKMRIPFQKLIFPVGSAFQGFGTPKRGQGSPSLKIRSQQGHQREYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF40</accession>
    <name>A0A2T4CF40_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1114535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF40"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="159" mass="17244" checksum="D1814235EE94009B" modified="2018-07-18" version="1">MSNTCSNGYNYFTPFPTITQWPLAQTSIPYPILPFLVCPSCPPLLASSSPRYPTHFPSDSSSFFPLCSTSLSLPLFPVLFFPNPSEIHSKLYLLNPSRSLPSPALPSLPPISPRPLHALPVSIQSSIHPSVSPSRNPNFQSSALLPSFVLARPIPSQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF85</accession>
    <name>A0A2T4CF85_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1435873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF85"/>
    <dbReference type="STRING" id="983965.A0A2T4CF85"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="39297" checksum="030C6D37365A2CE6" modified="2018-07-18" version="1">MNYLYSTVNTLRDRYTPVTHTSTFRATGQITPEEFVAAGDYLVYKFPTWSWSDADSEALRASYLPPGKQFLVTRNVPCHRRLNDDFAGDAAHEESIIHEGDDFKTRADAADDDGWLRTGGLASSQPLKAREVKTVDDSGNVGDDDLYGLDDDIPDMEDEEEDDAVLRIEPGNTARRTYNLYIMYTPYYRTPRLYLSGYQANGHPLPPMKMMEDIVGDYKDKTVTLEEFPFFSSRVRMASVHPCKHAPVMKSLLDRADAALRLRREKLKASKRQSADGKDVEGLADELENLDVKGAHEAADKDEWEEVQENEVDDQEVAIRVDQYLVVFLKFMASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFF8</accession>
    <name>A0A2T4CFF8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFF8"/>
    <dbReference type="OrthoDB" id="5230947at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="73" mass="7695" checksum="B5DEBEC6A9B281F8" modified="2018-07-18" version="1">MGAVVSCFEAIFRTIGSVIMAIISGIGNMLTAIINGIVAFFGIIISCLTCGRSGGNRRYRHRGMGGSRVRSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFV1</accession>
    <name>A0A2T4CFV1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1397782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFV1"/>
    <dbReference type="STRING" id="983965.A0A2T4CFV1"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="233" mass="25849" checksum="CFA6ED9CFB5F9E7E" modified="2018-07-18" version="1">MMKPTTSVPAIRIVTKSALAQTARPVFARSFATPTGLGTTATPKSKRRSVTPFNDTGFVPWSELSGAEKAARATQQSYNFGMVIVGLVCTGGVAYFLWTDVFSPESKTNQFNRAVNMIKKDHRCLELLGDANKIHAHGDETFNKWRRARPITSTETRDAQGNQHLKMHFYVEGPLANGVVQCHMVKPAGQSDYEYKYLFVDVKGHERIYLENADTAAARSGKKPVTFFGVKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFZ0</accession>
    <name>A0A2T4CFZ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_196010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFZ0"/>
    <dbReference type="OrthoDB" id="4900413at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="27009" checksum="316AFC7E9064EBEB" modified="2018-07-18" version="1">MPPKRRLPMHQKDAAQEIAETPAPEPASSSPTAPPAQRPKIEEEGPEWLKRAPGNVRWVEGDLNGNIAGIASIAFAAVTMLEKLNAGNADRADVNDIRAALKYMGGAKVVDEFSRKIHEQVGFFKPKPQPETSAFSKLFDDMAWQANPLDNDDDDAEAGEAGGRQASIELGMTPAPMEKTTTTAAGREREGSEELGAATGEAATGPVVIPSDPESSSLSSLSSNVSPLAQKSARAAEKSVVTSKYFGPGAGAGGASGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG19</accession>
    <name>A0A2T4CG19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_195948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG19"/>
    <dbReference type="OrthoDB" id="10516392at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="170" mass="18411" checksum="A9A81091D0624470" modified="2018-07-18" version="1">MITSEQTKARLQRRKAQQQAAHHIISQPCRQPSASSTPIVTCRRSARASSSSSPASSSSVHKGSIRPTAGLVHAYPAPRDSTLHGLSPLAHAKKPYAGQYVLRTLQQYQQPDCFGLLADCGFRKPPAAGMDCMTDCSCSFARTRAASTYMIHSGMLQHISTLAGNRRETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG85</accession>
    <name>A0A2T4CG85_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1436131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG85"/>
    <dbReference type="STRING" id="983965.A0A2T4CG85"/>
    <dbReference type="OrthoDB" id="2163411at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="57870" checksum="D73C28180C9C149F" modified="2018-07-18" version="1">MLSLLAGTATAQDGCISLKGSTTCPAFQAASISTNQSLIDTFSFLQYVSDRESFDNELSSFVKTSYLKDKFQSTFGCHDVNFTSPSDMYARYTTTVICNSIVQMSAQGCGVSSQNSQPLCAETCAEYAQSEAYITADTALCADPSTDLNKLIRADFTVCALPEQALSGECVNGVDNEPDNCGFGNSTIGLCSYCGAGGINSTDTCCYSANAESRCKGVKLPDITATLTFTTPAATSTSTTSPAAATSGGGHHLSGGAIAGIVIGSLAGVAILAALLFFCIRFLRRRPSSAQGSIFNQPTPARKGPPMSQGSAAPPRGYEVLPGGRIARMSALEGHSGDSPSRHGSSPSGRAVPYAAKASDRMSSSEFGDAPEPETPYTTLRGPPMTSRRQGSLSSNSMLGSEVGSPIGFSSPGGLASQQSEQLPFFKDYYSQDDIHPGDKVAVLWAYQPRAPDEFALERGDMLKVVGIWDDGWATGLMVDQRADEWEARRQAQRDSGVSSSSAPRDHSPQGYGDLKAFPLVCVCLPEHWKKTIDGDGSTDTGASGIHGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGW5</accession>
    <name>A0A2T4CGW5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metallo-hydrolase/oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1370237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGW5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGW5"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="9">
        <location>
            <begin position="301"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="10">
        <location>
            <begin position="567"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="779"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="100471" checksum="59F9ADF941F91109" modified="2018-07-18" version="1">MASKRKASAMNAAASDEPVDPSDELMFLCLGGGNEVGRSCHIIQYKGKTVMLDAGQHPAYDGLAALPFYDDFDLSTVDVLLISHEGKRACSICTVDVAMCALMQCFSLHCLCLSPVLSIHGNSFHIDHAASLPYVLAKTNFRGRVFMTHPTKAIYKWLIQDSVRVGNTASNSATQLYTEQDHLNTFPQIEAIDYHTTHTISSIRITPYPAGHVLGAAMFLIEIAGLNIFFTGDYSREQDRHLVSAEVPKGIKIDVLITESTYGIASHVPRLEREQALMKSITGILNRGGRALLPVFALGRAQELLLILDEYWTKHAEYQKFPIYYASNLARKCMVIYQTYVGAMNDNIKRLFRERMAESEASGDSAGKNGPWDFKFIRSLKNLDRFDDVGGCVMLASPGMLQNGVSRELLERWAPSEKNGVIITGYSVEGTMARQIMQEPDQIPAVMSRSIAGARRGPGSDSEKVLIPRRCSVQEYSFAAHVDGVENREFIEEVAAPVVILVHGEQHNMMRLKSKLLSLNAHKSLKVKVYSPRNCEELRIPFKADKTAKVVGKLASIPPPTDPDAPAPLVTGVLVQNDFKLSLMAPEDLREYAGLNTTTITCKQRLTLSAAGVDLVRWALEGTFGAVEELPEMRRVVAKKNGGNASDGDGDEKMAEYADEEVANLVAAYLVMGCVSVRYRTNGEVELEWEGNMLNDGIADSVMAVLFSVESSPAAVKRSSNNTKHSHSHHHSHESSSSSAKGLYAAQLDSKNPHAHISPDDRLERLMWFLEAQFGADNVAPVEDPKLPPLPISLKEEKKAESNNDDDSDDDESMDVDNSNINASEDDDADDAKKQQQQQQAEQEQEERKHKELARLHKLGIPVPGISIRVDKMAATVWLEDLEVECGNKVLADRVRAVVERAVEVTAPLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH54</accession>
    <name>A0A2T4CH54_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1001074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH54"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="169" mass="19162" checksum="D3A47BF7227875B5" modified="2018-07-18" version="1">MLDLPFHWLHLLTETKPLPSVTSTSKLDRQPELSIIQQSSPNPCSNRVRLCKQRQQTAASIITYHHILLLLATSSDRTSGRLCICFAARPLWIDTSVESLCGLDKTEIRAGRRLQLLWALHPLDGGRSELVCLSCPHLAKPRLGRSTLILRPPFQAVPLRHTRFIHTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHF1</accession>
    <name>A0A2T4CHF1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1434871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHF1"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="201" mass="21823" checksum="2B381B7E87D4575A" modified="2018-07-18" version="1">MFCSSLRQRKDWAAVVLLLSSEESKTATAKARIERLSMLDGGKNVAIILLMEQGGCVDSLVHLQMSFMTHGISSMLIIPISSASELPSRLDALRRQLASAANISRTRTNHRADEAACAEQLRDLASHCAHGQALSREHVDVLTDLSAGLGSLAQLSFSADGQRRIRDLLGDVQGGRVIAFFTHGYEKSHRLGVWGQSLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHF2</accession>
    <name>A0A2T4CHF2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome subunit alpha 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1345413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHF2"/>
    <dbReference type="STRING" id="983965.A0A2T4CHF2"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="253" mass="27880" checksum="241C2242433739E4" modified="2018-07-18" version="1">MSASAYDRHITIFADNGRLYQVEYAFKAITAANIMSVGLRGKDCAVVLSQKKVPDKLIDPSSVSHIFQISPSVGCVITGSIADARAFAQRAQGEAAEFRYKYGYEMPADVLAKRLANISQVYTQRAYMRPYGVATTIISLDEERGPQLYKCDPAGYFIGYKGTAAGPKQQEAMNHLEKKLRNKEHAEGSWEEVVELAITTLSTVLSMDFKKGEIEIGIVGGPRADGKEGTEPGFRKLTEDEIEERLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI69</accession>
    <name>A0A2T4CI69_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1322734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI69"/>
    <dbReference type="OrthoDB" id="5397330at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="229" mass="25364" checksum="451DDBCED0903F2B" modified="2018-07-18" version="1">MPIRNPFARRPGPLATANDSTLTDQERSHSGFERVDTVGSKASSALSIRSARSQDTGEYKMSVVNDSGVYLPPSPSEEKSQWPRRYLSSRESSDSSCEIEQFSISRESFDSYRRSFDISARSPIAAYDVPARQSLDSARFARMPRSAINRNMEQLPTAEENFEDVGLDDQKQPPRKRGFFSKLTETQEKDASSPQTGVSRFLMPGRKRAQSGQGSELGTIEPPAVASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CII9</accession>
    <name>A0A2T4CII9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1323383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CII9"/>
    <dbReference type="STRING" id="983965.A0A2T4CII9"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="8315" checksum="3174CA0A3353DCBC" modified="2018-07-18" version="1" fragment="single">MAVFGLPGLLDHLPPSADLEAQNERGHTGLYLACLHGHLDMAKALLARGADPDVQCGSHGSPLGAACYRGYGSVVEMLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ44</accession>
    <name>A0A2T4CJ44_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_15905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ44"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ44"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="116" mass="13858" checksum="FC4F361B8BA4C66D" modified="2018-07-18" version="1">MEAAVEKPAAKPTKPLGMRKNGMQWHAPKKAFRPTAGLSSYEQRAKERAAMAQVKAKEKEMKQEKEEERQRRIQAIKDKRAKKEERERYEKMAEKMHRKRVERLKRKEKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJB2</accession>
    <name>A0A2T4CJB2_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1435362</name>
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    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
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            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4825861at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="17299" checksum="13B9273E3D26C27B" modified="2018-07-18" version="1">MAIRERFRRALRRSDDSDTIISQTDSNTTIASSSARQSSSSESAPQLSLKKTSSTLSRTLASFSLRSKEKDKEKEAAKREERDRRRNKNRKWKHPSEKPLTEQNLKHQEMLSHFKMEFGASDPSQILQDLDLEGISPCCTRVNSCDLGPDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJN3</accession>
    <name>A0A2T4CJN3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1023099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJN3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="10633" checksum="CC72A983BB64F0F2" modified="2018-07-18" version="1">MYHSHEASTDMVKVMLCTFTSVFATIRHLVETLEVVVLQMPRQHPGVVLGMNSCPNTSPSSRVSLVPGAACPDQRLVNVVIFLLSYVTLLWTVYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJQ0</accession>
    <name>A0A2T4CJQ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1322038</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJQ0"/>
    <dbReference type="STRING" id="983965.A0A2T4CJQ0"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB81780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="498" mass="54598" checksum="984E6ACBA211D65B" modified="2018-07-18" version="1">MDVEEQRIGSVAPDDKEEDSTPTSDPESAPESSHALDWENDPRNPYNWSDGKRLYHTVCVSLYAFTVTYMSSAYAPGAKATGHDLHVSETVSLLGISLFCLGLAFGPVIGAPLSESAGRLIVYRLGLPVCILFLIGAATSNNIGGVVVCRFFAGVFGSPALSVGGGTMADMWPPARRGPATALFVMAPFMGPCIAPIIGGFVVERLNWRWLEWVSIFWGLATCVFAIGMQETYKKILLARSNNKNIKEKLTSRVKMPTLSWSAICKWASESLVTPMHLLFTEPIVLFLSLYIGFDFAVLYAFFASIPLVFQKTYSFNSHQNGLVFISLGIGALLATATNILCDRLIYQREAKAARAKGDTGHIAPEHRLYPAMMGSLGVAIGLFWFAWTARPDIHWISPVLALIPFNWGNLCIFACSITYMIDCYGARYGASALSANAFTRYVFAAAFPLFVIQMYNNLTTKWAASLLGFTAIALIPIPWVLFKFGATIRKKTRYALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJS5</accession>
    <name>A0A2T4CJS5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1427588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJS5"/>
    <dbReference type="OrthoDB" id="4881457at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="268" mass="30989" checksum="3ADDE01B7EC965A1" modified="2018-07-18" version="1">MDATATNATSARDARRGPGDREAPFKYAITMRPDQPEEITFYQRLEDGFRWLEIPPNATFERKTWDIGLAINHHGTTNSLNSAAFGAATHWGVFLCPVTADNEEQPYRVFGLNFRDAARQEFILGQKWQTADREFQTNVARSDFDTKEEYNMRVVCSFEEFVLTAQMVLQEFQTSDKVSMGGMSQGGYAYSLFFNNCQNYALALLKEIKDRGWESRHQSWDSRFKLADLASTLLRSREDSRNRYQDYEGDFRTRGGDDESFTRWARGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK06</accession>
    <name>A0A2T4CK06_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1322138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK06"/>
    <dbReference type="STRING" id="983965.A0A2T4CK06"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="552" mass="60285" checksum="EF8BE21A8FBEB6BB" modified="2018-07-18" version="1">MCGVTGLMLGDPEATTAAIELHESLFYLQHASQDAAGISVCNGGRVYQRKGLGMAQKVFSEFDGLALLEQLPGAFGIAHVRYPTAGTSSASEAQPLYVNSPFGLSISVNGNLINPDYLREFLDSEARRHINSDSDSELLLNVFAYSLNELGKARVNVDDIFTSLRDVYAKCQGAYACTAMVTGFGILGFRDANGIRPLCFGSRPSQTLPGAKDYFLASESVALRQLGFTDIIDIKPGQAVFCQKNGTVHFRQIVEPRSYTPDVFEYVYLARPDSCIDGISVHRSRQNMGVKLAKKMREVLTEKEIAEIDVVIPVPETSNTAAATLASCLDRPYSNAFVKNRYANFSFVFRTFILPGQEARKKGIRRKLSPIESEFDGKAICIVDDSIVRGNTSREIVQMAREAGATRVYVVSCSPEIMNQHIYGIDLADPDELVAYNRTTEQVAENIQADKVIFQSLDDLKAACVEAAGEGSEVKEFEVGVFSGKYITDVPEGYFEHISQLRGKNKKRKANCSESMLIANGGVVNMAPGQNGAQGNGARNGVVSPSYREDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK55</accession>
    <name>A0A2T4CK55_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1322830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK55"/>
    <dbReference type="STRING" id="983965.A0A2T4CK55"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="185"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="634" mass="69421" checksum="8AC390675089C3D9" modified="2018-07-18" version="1">MATKATKVAKGHEHDKRKGESALSDFAEYVEQQQNLRYPASNKKPVPDSAEHDAELDELLDSLNLVDSAPRVKLKDLVLGSDDDSLQKLGDVIVERIEEGAGETVFDLGFENSGESMQLTLDEWNKAYARLVEAAKKVRADCQLLLTTNVGGKEEAESTATSPPKDKSCSGKILIRRIPARVEDVIETRIAVVGNVDAGKSSLLGVLVKNDLDDGRGKARVNLFRHKHEMETGRTSSVGMEIMGFDSHGQVITSDTPGRKLSWEDIGKHSAKVITFSDLAGHEKYLRTTVFGLLSSSPDFCLLMVAANNGLVGMSKEHLGIALALNVPVMVIITKIDICPPNILEQTISQVNKIMKSPGARKMPTFITNREECVNTATQFVSKRICPVFQVSNVTGENLDLVRMFLNMLPHHGHYHSDAPFEFQVNDTFSVPFTGTVVSGIVKSGMVHEGDNVLIGPDSLGHFMPTAVRSIERKRIRVQVAEAGQSASFALKKMKRRDVRKGMVMLHREEGQTGPKVYREFVAEVLILSHATTIKKRYQAMLHVGAVSQTCAIIDIDRELIRTGDRANVAFRFVQRPEYIAPGDRLLFREGRTKGLGIVKSVGYDASHPLSSTLDDGDKVAAPAVGTNDVASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP85</accession>
    <name>A0A2T4BP85_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1406864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679153">
        <property type="protein sequence ID" value="PTB71122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP85"/>
    <dbReference type="STRING" id="983965.A0A2T4BP85"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="76"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="365" mass="41206" checksum="8876BAC01A91EC0F" modified="2018-07-18" version="1">MSATQTVTKSDTAIGKLTLAYDDTIHQKYKYHDYLPVYDEETHFGPIQPFEFTDRGLAADKSKSALLSDSNPDLKVSKLTPVIGTEIRGLQLSQLNDTQKNELALLIAERGVVIFRDQDFKDIGPEKQKEFARYFGPLHIHPVGAHVKGHLEYHNIYLGPDNEYRARQRRERLTTTGYHSDVSYEHQPPGITILTLLSVPPTGGDTVWASQTAAYSRLSQPIKTLLEGLRAEHSGFNQAENARRDGRHVRREPVKSEHPIVRVHPVTGEKALFVNKGFTKRIIGLQHEESDALLQLLFNHIALGQDFQVRVKWEEGTVALWDNRVTAHTAISDFNHHNPQEGLRHGIRLTTQADKPTGVNRLESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPN9</accession>
    <name>A0A2T4BPN9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1426723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPN9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPN9"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015747434" description="alpha-1,2-Mannosidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB71219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="523" mass="56232" checksum="391E7D886E6CCAB4" modified="2018-07-18" version="1">MRFPSSSVIALGLIGSALAYPKPGATKRGSPNPTRAAAVKAAFQTSWNAYHQFAFPHDDLHPVSNGFDDERNGWGSSAIDGLDTAILMEDADIVNTILQHVPQINFTTTAVANQGISVFETNIRYIGGLLSAYDLLRGPFSSLATNQTLVNSLLSQAQTLANGLKVAFTTPSGVPDPTVYFNPTVRRSGASSNNVAEIGSLVLEWTRLSDLTGNPVYGQLAQKGESYLLNPKGSPEAWPGLIGTFVSTGNGTFQDSSGSWSGLMDSFYEYLIKMYLYDPVTFAHYKDRWVLAADSTIAHLASHPSTRKDLTFLSSYNGQSTSPNSGHLASFAGGNFILGGILLNQQKYIDFGIKLASSYFATYNQTASGIGPEGFAWVDSATGAGGSPPSSQSGFYSSAGFWVTAPYYILRPETLESLYYAYRVTGDSKWQDLAWEAFSAIEDACRAGSAYSSINDVTQANGGGASDDMESFWFAEALKYAYLIFAEESDVQLQANGGNKFVFNTEAHPFSIRSASRRGGHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ43</accession>
    <name>A0A2T4BQ43_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BQ43"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="275" mass="30763" checksum="A0E673254E77D8C6" modified="2018-07-18" version="1">MDSSTPITLYDIAHKPPVTKHCFSPNPWKSRFALNFKALPYTTSWVRMPDIPQARRDLGLPACRKFADGTDFYTLPVIKDDSTGAVVGDSFDIAVYLQRTYPESGGGDLFPEQTLDFTFDPGYPLAVPLSERADGGHPDYYRFNTNVDAAFTSHVPLMVSRMAFDPETEAQTKAEFVRRAGVKSWDDFALTSEARGKFMQSFEAALGGLAKLYRRDPSGPFLLGKRASYADFIVGAWLRMSSMCLPESEWEEVRGWHDGVFGKLHDGLEAYAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ66</accession>
    <name>A0A2T4BQ66_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ66"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ66"/>
    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="797" mass="87595" checksum="4346548E77055E72" modified="2018-07-18" version="1">MTLATSPAHDVAKLMGRRNITIIPKDQKALLERKDSWAIDQDGTKGLATVPKQVLQTLKEAFVRHQGETEQENPEEDEEEDEEQEGEEEEENPELPHLSAANDRGRQNGHLPGSTAARPSSPPPSSPEVPVSSWSESPARSRGRAQDAMSDADSPDEAPGSPMHMAVPEVLSQPLFHATPNPSALSEPEDLEMELPQAHEAREAPINRVATVLRPAAATQEPASLVTSLPSTTDTPPCAQPQAATSSGTPKSSVVKADAAAHGRSRRMKPIAFSEDNSPKPAATAAPAPHPSPFTRRHSMRSLPGPHVDNSLYSSSDTPAPFEQERAHRCPSPPPPPPPPHNFTRNSTAQQQQRRSYGQLDGAASRDVSPSRQTPMHQLYRIQAAVDVSISDRVAPYRAFTATYPDYTTVHSGNLLSFIQACVYLRMLQEERRMREYLYDDFIRAWSSGFLPYVQNAGPGQEPLPAVEWFNMLKGPILFNRMCVNAGNIDMVLNAYPEEASRIKAILERSLQTEQSPEPEPELLPGIEMELEPESELEPEPEPRRKRRHEPEVIDILTSDSAMDIAADEEPQSEPHPPPPPPPTREAPSLPAPSRTAPPPPPPRPASPELGSDDYFATPPLPPKPPSSARPRARSRSRSRSPSRSQQPSRAREAQQAQPRPIPQTQHPQLQPQRQITLPQRQSPKRRQTAPSQPPIPVSFAAPPPSSSTTATPSKRPRPRSLHQPTERKQQQQQHHHQGGEHAVPSSSRPITSSTSSVNRPIPKPRKRSAEERARLKEHFRKKATSSATSHVGGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQD8</accession>
    <name>A0A2T4BQD8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_350673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQD8"/>
    <dbReference type="STRING" id="983965.A0A2T4BQD8"/>
    <dbReference type="OrthoDB" id="5308502at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="295" mass="32935" checksum="FC07988E9C7BAA14" modified="2018-07-18" version="1">MIRYDVFDARDLLAFPGGDNSTDTVFGGVHFNLTTLQHWNYTYYSNGTLSNNSRCYLTYEPYEPKLLISNGTFINATKCYSAVDPIAVRGYTGIGFAVAYAIGLMLTLSCLAKHGRLYLPKEKRFYPIGRRWQWYWGCFVSACALISLFTNIDIDRYHVGGKRGLRARFEAEAEGETGGKDDGIEMASMSQRDNPRVDRAGVGSLADRYAGKSERRHNERIVESFAGVLFPNNVDPERARRIAEITADGPPPYRDDDRGRSSRQHGASNGQRNGSTDTTNSIAAPPQQVRSMLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQH1</accession>
    <name>A0A2T4BQH1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1442487</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQH1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQH1"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="12">
        <location>
            <begin position="248"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="575"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="775" mass="84801" checksum="EA9014ECCF9C49B2" modified="2018-07-18" version="1">MEAAGDAPGARETESPGLVESIVAIDVRDKRAMGCSIFSAADGVLKIANDIPMANENVAEEFLNYAQATTILMSRRVPEAILTFVEKHVERSTQNLHLRLMPSSDFSHTFACEELSSLGINGDCSFPSASPLNAEEQCIGSNGQAVQRSGPDEPHCMKLVRCGSLIDLESVASLSCASALLTELHRRRSLSSSHSNPGIFGVRSVTIFNLADHVFISEESLLSLQIINHESHPNSQAWSIDSNSSSEKENLSIYGLLHPLASTPQGRAHLRHMFLQPTSNLGVITDRQRTISLLLHPNNEEKSRRVGSGTLKRFASQSLKFREIAMAFSHANQSSIVNKVIDVIDPLVLTRVGDLIERVVNFDQAKSQQRYSVRSGIDDGLDGLKRQYDGLNSFLTEVANHVAQDLPVWARQYIRSCIFLPQLGFLTVVEQDHQQSGSSFDEDCAGDGRWKKLFTDNETAYYKNHPMTELDEQYGDIYSQISDREVEVMQRLAMDVIVHEKSLLAAAAVCGEFDALLALAVGAAKFGWKAPQVTTANILHIKGGRHPLQELLSPSFVSNDCYIGDDDIVAPGRTVQALVLTGPNQSGKSVYIKQVAIIVYLAHVGSFVPADDAVIGTVDKILTRISLRESVSGTGSTFGHDLKDVSHAMKYSTARSLVLIDEFGNGTTANDGAGMFAAMLDYFLSSVAETPRILAATHFHEIFANGYLSHYATLKLAHMEVRTDWDAIDPEDQVTYLFRLIEGYSSTSLGSQCAVLSGIPEGIITRVKEIEELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQS1</accession>
    <name>A0A2T4BQS1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_213463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQS1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQS1"/>
    <dbReference type="OrthoDB" id="5095473at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="131" mass="14075" checksum="A8D66FCF6FDE7ACB" modified="2018-07-18" version="1">MIEIVMDDDEAEEPMTAAPNDGMVPVLGQPEPPVKGHNRGRSLGEGSLSGRRTKATERLRSGSRSRKGSIGVMSPPLEMYGGEGNPNSLNQLRSPVAGIPPPVLYDRDAIRSPIEGHGRKMSMGLHENGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQZ1</accession>
    <name>A0A2T4BQZ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1343482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQZ1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQZ1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="294" mass="31462" checksum="F858FD3918F7E78F" modified="2018-07-18" version="1">MDLATFEGSFAPAVRPRGVRLTPWYRSRDYFIGQWLDVSVWKSAVVEMVATSCLVFVSGQITATIEGYGTPQVGGYIGISNIILLSTFIYATAPASGGHLNPMITFSAILTGLCSVPRGVLYLCGQTLGGALAGGLLLGVWGRERATSLQGGGCWYDPSQASPGQIYLNEVFSSFVLLFLSFGVGLDPRQAALFGPRMGPLLVGASLGLVTFSSSGIIPGYAGAQMNPSRCLAFGIARRNMSYQWVWWFGPAVGGLIEAIVYNLIPPHHMELVKQKSKETEPDTMVGHTDIPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR14</accession>
    <name>A0A2T4BR14_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1140332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR14"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="89" mass="9734" checksum="EBBAC4B60C3DEA57" modified="2018-07-18" version="1">MTPTSQASLLFLATSYRLPSSSRLACLPILMIHDSILPRPGPFHKTKFVELAVSADLAWAWPGADYRATTTSSSRVWSFTSTSKSSMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR79</accession>
    <name>A0A2T4BR79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1343301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR79"/>
    <dbReference type="STRING" id="983965.A0A2T4BR79"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="296" mass="33339" checksum="4BF5EBAD2F2FD4C4" modified="2018-07-18" version="1">MANVTGAIIPVISHLEVGDYNVFYREAGPVNAPTVLLLHGFPTSSFMFRHLIPILAVTYHVIALDYPGFGFTKGPAKYPHTFENIATMTEEFLKALHISKYALYIFDYGAPVGLKLAVRNPQAVSAIVSQKGNAYVEGLGPFWDPVKVYWETGSKTDRDALEGVLSFNTTMGQYTGGTENPAILEPESWWLDWTLMANRPGNDDYQLDLFYDYRNNVKQYPEFQKYFRNSQVPLLAVWGQKDTIFIPPGAQAFRRDLPHAEIHLLDAGHFTLISNLEQMVGYILPFLEKHLGKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRF7</accession>
    <name>A0A2T4BRF7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_61553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRF7"/>
    <dbReference type="STRING" id="983965.A0A2T4BRF7"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="264"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="338"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="451" mass="48648" checksum="D9C59AA1AE8D70B5" modified="2018-07-18" version="1">MEYRTPPVSEAKLRIQPRLIIHGGAGNIQRSNFPPEKYAAYRDALLSIVTKTQTFMNSSPSSYNEKIKKHPSALDIATHAVVLLEDNPLFNSGHGAVFTRDGVNELEASVMVSRGLKKRGVGVMGLRRVRNPILLAKRMLERGEEDLAPAGDDDDDVTGHVKGNDDLDVPSAQGHTQLHGPTAEKLATRYGLPLVDPSYFFTQQRWDEHIRALEREKSGIPSSATWHADEYLPQGTCGAVALDAEGVICAATSTGGMTNKLTGRIGDTPVVGAGFWAEEWDEDVEEEVFRADPGISFAGPLKGLLADCFPTPWMHSPSFEPLQAAATSRSRSVGFSGTGNGDSFLRVNAVRTVAAIARYRPCPGSLALAKVAGPGGQLQQSAGDRWGRTGEGEGGIIGLECVLERDQDGRVVGARSEVLMEYNCGGMYRAWIDDEGKPVMSIWSNGSADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRS9</accession>
    <name>A0A2T4BRS9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1342960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRS9"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="582" mass="62171" checksum="6776DBEB0A586924" modified="2018-07-18" version="1">MTTEYRVSLSYPNPSLGQMVAGSQTSNSIDDEASRSKLGYGGSGKVRGLQRAALVITLLVGLLISTLDTTIVSTSLVTISNDLDDFVNAPWIVLAYLLTYMGFAVCISKMSDIYGRRNILVLSWVVFSGFSLGCANAKHMTALIACRAFQGIGASGLYSLTQIALVEVGPAHRPSLIGAMIGATLAIAFVLGPLLGGLISMHSDWRWLFNLNIPFGLVAMLAITSLWPREEVSHLLSWDAFTSIDFVGSTTLLCGSSLLVFAIQQAGSQTVAWSSPEVISALVISGISWAAFIGWEVVLDSKSHRHVEPIFPIRLMSHRVYASGLLLTLLTGFPYISLTVIIPERFQIVKGEDALMAGIHLFPLLGACAVGSFLGGAISSKRNNTSYTLIGSSCLQLLGLGLMTTRKQTESAEASQYAYQAIFGLGVGLCFSATTIMTSICTAESSEKATAQGAVAQARVLGGSIGLSVCTVIFNIHVNRYLEGRLSKAQLEDLHRSPLSGLQLPVDQQDAVKTVYAGAYAEEIKILACVCSVMVVIALFTLERRPTPLNIVHSGSKEGPFSRRGSDSGTELSDIRNTHQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRX2</accession>
    <name>A0A2T4BRX2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">M440DRAFT_1343095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB72016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRX2"/>
    <dbReference type="STRING" id="983965.A0A2T4BRX2"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB72016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="453" mass="48649" checksum="07C356EC13A7A543" modified="2018-07-18" version="1">MASSSSSSSSAAVVPLQSLQPDLHERAWTSVPHPSLPLVATAHGKNVTVFSLSTLSFHSTLADGHARSVRSVAWKPGLPPHELCLVTGSFDSSAGVWRWAREGGDGDDDGDGDGDGLGRDMTRTTADDGDSAKAGGDWDFNLVLEGHDSEIKGCAFSPSGTYLATCSRDKSIWIWEDIASAEGEDDWETIAVLNEHEGDVKAVAWCPDVPGRNSVGRRYYSVDVLASASYDNTARIWREDSDGEWVCVAVLEGHQGTVWGVEWEPRPKDDAFPRLLTFSADGTIRVWTLQQDEDGAGADGSAMPHGLGGIPSTMRRSFKEEWKCTAVLPKVHDKDVYSATWSAASGLVASTGSDGVIALYKEDSDSVAEPQAGSEDNTPDGAPRSTHDGQSTGGPQWRLLTTVPNAHGPYEINHITWCKRYDAGSTRRGEEEMLVTTGDDGVVQSWQVDITSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS27</accession>
    <name>A0A2T4BS27_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPCR, GprK-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1364256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS27"/>
    <dbReference type="STRING" id="983965.A0A2T4BS27"/>
    <dbReference type="OrthoDB" id="5313079at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="566" mass="64713" checksum="D0E4B82663681C3B" modified="2018-07-18" version="1">MATVYTLPPSPPNLDGVGIFYISWCASWTALVLAGMAFCWLNRDIPVLKIRGLPLSFCAIALLHLYWILAQITYPVGRTLPVVLAYDVQYFFMSLWFPLGVALFHASNLRFLRVAQLQRQFTTHPAVRRVEPGCGGKASWLCRLRGYDHTKRSLLFIGLGMVVQFMLTIGMWVACRKYHPAFGIPGTEIRGATVAEQVVELGRGWEWWPSVLWQVVWTWIVAPVLIWRAWGIRDTMGWRTQTIGCCISNLHATPMFMIASYVPAFDKVNQYFTPSQWIHLSILMFEVFTVFVPVFQVFRFRAQQKKAARLNAEWDTFSTAHTLCASSSEDWIFSAKASTPKMRAIDLFDEDLGDRFLTMNVLEQVLSEDPGPLQEFSALRDFSGENIAFLTSVARWKSSWMEKLSSEQKRQLYNGALEIYIDYISPKDAEFPLNLSSGEVKRLQDMFEKAARIVCGESNINPATPFDIEVAPVRSCETESSSESNSRATHRARYHGEIPDAFDATVFDSIESHIKYLVLTNTWPKFVDEMQSKKRRRSTETARTEGTWKSESTLTNRIMHLVHQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSE3</accession>
    <name>A0A2T4BSE3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1448714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSE3"/>
    <dbReference type="STRING" id="983965.A0A2T4BSE3"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="13045" checksum="85666898E33CBD71" modified="2018-07-18" version="1">MLASLLHYPADHKSGVFEGRLREAIAIRTHTLPSTSYSRQIERRIEQTLYAAKLNIFNPLHGLKLKFKIICSNVFGIDHTSGSEKAEDSIDHLKHFYKHLRQPFRCALDVGIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTD5</accession>
    <name>A0A2T4BTD5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1341715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTD5"/>
    <dbReference type="STRING" id="983965.A0A2T4BTD5"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="5651" checksum="30A384C769119D76" modified="2018-07-18" version="1">MGPPKPPVPHVAPIYRVTATALGAGMWFWLMYRAKKDGPALLGWKHPWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTQ4</accession>
    <name>A0A2T4BTQ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF914-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1079844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTQ4"/>
    <dbReference type="STRING" id="983965.A0A2T4BTQ4"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="479" mass="51659" checksum="6AE68453E7D4F2F5" modified="2018-07-18" version="1">MNPSKQHTPRLRSASPTASLSATATATASSSASAASSTSQPLLASGQHVSYGAANMTAPTNPVEADSKLGFTSTVISSGSGDKNEGSNPGKNSDGNNVDGTLNGTADEAVLSQGIQILEAKSVHWWSYLTTVDFWIVIAVGQVLSLCITGTNTFTSFLANAGTNIPAFQTVFNYILLFLIYTSITLWRDGPRVWFDILLKDGWRYFIMSFLDVEGNYFTVLAYRYTNLLSAQLLNFWSIVCVVIISFLLLRVRYKLFQVLGILICCGGMGILLASDHITGSNGGPGVDMVKGDLFGLLGATLYGVSNVFEEWLVSKRPMHHVLAFMGFFGMFINGVQAAIFDRQSFRDAHWDSSVGGWLAGYTICLCIFYTLAPLILRMGSAAFFDISLLTANFWGVIIGIHVFGYVIHYLYPIAFVCIIIGLVIYFLSGSMLGDSKKPWLGENQEDGVAGFGTAKLRALNAARKAQAEAGAEAAVGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUC4</accession>
    <name>A0A2T4BUC4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1433648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUC4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUC4"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="256" mass="28610" checksum="FD60604A8491FF52" modified="2018-07-18" version="1">MNPASRPWHGQLLGLLRTGLRFAHSGQPRGTSQAAQSAAGHGEDIWVFAHRRSEQVIYSFSRQLDGFHDLKQLPFNGKKTKPAKLRKDYWSPLAHIRFQPGQGSIGRSVFQKLRELKHLHEVAWGDEMRHKRPEEYTSEDKKKIAAEKEKGFDYQPIRSKKERGLALNAQKKNAIADIAYVLAGGGRGNKLVTAETEAGGKELVGVTVNWANDQDRKYAASWSKNVTHSLLDVPAYTSGELQKEVEATKEASKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUJ4</accession>
    <name>A0A2T4BUJ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1441274</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-dehydroepisterol + NADPH + O2 + H(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:33467"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:52972"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33468"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUJ4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUJ4"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB72977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="538" mass="60933" checksum="FA1ED4BBDB21E04D" modified="2018-07-18" version="1">MDAVNATRAPSVLTSVLANSKYVSANMPPHVDYVIETIAAAGAWTWFFTILAICVAYDQISYLMNKGSIVGPAWKQPFIGPFLQSMDPKFEEYYAKWKSGPLSCVSVFHKFVVIASTRDMARKVLNSPAYVKPCVVDAAYKLLGEDNWVFLDGKPHVDFRKGLNGLFTRKALECYLPGQEEVYKAYFKRFLEVTKANGGKPVPFMPEFRELMCAVSCRTFVGHYISDEAVKKIADDYYLITAALELVNFPIILPYTKTWYGKKAADMVLAEFAKCAAKSKVRMAAGGEVTCIMDGWVLQMIQSERWREAEEKGLSTEGLVKPAPMLRMFRDYEISQTIFTFLFASQDATSSAATWLFQVTAQRPDVLDRVREENLKVRNGDPYAELNMDQLESLTYTRAVVRELLRYRPPVLMVPYKVKKPFPITENYTVPKGAMLIPTTYMALHDPDVYENPDYFDPERYYSGDAETKGAKNYLVFGTGAHYCLGQVYAQLNLALMLGKASVQMNWTHHATPLSEEIKVFATIFPKDDCPLTFEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUR9</accession>
    <name>A0A2T4BUR9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1340263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUR9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUR9"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015753835" evidence="6">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="414" mass="43755" checksum="18CCAE4E70CDD281" modified="2018-07-18" version="1">MARRSTLAALAASCLFLLAAASQIKTTPAAIDSLSLQELDSQLQTCPVVEQLNAAKLAHFESSPSSLTTTLFSVLFPGSPATNALLATLYISGPPNFLLALVPTNIDPSSLSVMVAFAVGGLLGDTLFHLLPEIFVGEDEPDRARFVLVEPNRNLILGLAILVGFMTFVAMDKGLRIATGGAGHEHSHNGHKHEEHKVSTDVGISTGANALKNEAKARKASKNTTKKPVDEQSQLKEINPSVKLGGYLNLIADFTHNITDGLAMSASFYASPTIGATTTVAVFFHEIPHEVGDFALLVQSGFSKRAAMASQFVTAIGAFMGTLIGIAVQEFGSGAADEGEGMPRNAGLWGTSLTWGDMLLPFTAGTFLYVGTVAVIPELLETGPNKMLELRKTLTQFTAVAVGAGIMLYISWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV72</accession>
    <name>A0A2T4BV72_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VTC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1441433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV72"/>
    <dbReference type="STRING" id="983965.A0A2T4BV72"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF1">
        <property type="entry name" value="VTC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="85309" checksum="51E4A2FF2B7B1A9B" modified="2018-07-18" version="1">MEQKKEKSRFWGGLLRGESLMKRGSRVVRKYQDLLRGEARDDVDGEWEEDVEDRELQPQQPSQQQQQQQQQLSEGSNSLVAPHRELPRRRRTIDGGSGSDIHRRSPRTSATRRRPDESLSGRLQTGFGKKRDSGADVSGSNDNAAATAGGRGRNVAQPAAANGGQNPRWPPTAVSSLDELPHRDALEMIAHGAPTFKGRKKAIPYASDQHYALYVTSSKTRSGGTDVARPNDAMSHLMTMKVQEHGHVSYPWETIEQPSYAFFYGRLGGTITLNQWAAAASNIPAKIPLRDSGVVPRPVSLEQIFARLKDLQQLGLEDDDLTLLYRSLYKRFLRDPEKLLSPHKTLDKQIADLIMALSRPGWIDYTEPKNQVVTRFIFNGSTDEGREQYHNFFHQLLLSLELDLRIQSRHHDDWAKEKLLQQMPPTIKWNLALARRWRENVRIETYGDSPQEVKLRYKLKKRQVKQLKKFAQIMKWPNLRDTMESLRQKDDDFSLDAISSDAFAYFSGLVLPGPTFSFLIMNTLIDLDPDPATNELALLSHMHPHSGFQYRNSHTYWSASCIVGKVLAPTCHAVAGWVGPCRPTSELGRSQIARIRTRQPKQLMTLEDVETMSTRSDALGPRADAYPVREYKLATLDSDRYVVDAVRMELLSFKPVPATGRESSASGPRLFDAQAQFAIDGVSWPLRLMYDKVLVVDAVGVRDNEVLARAWCAHWGLSAVVADIHNTCMACAIREAYAATLTVVILTEDHSHDNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVE3</accession>
    <name>A0A2T4BVE3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tcp11-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1441492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVE3"/>
    <dbReference type="STRING" id="983965.A0A2T4BVE3"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="92833" checksum="D49C9ED6BED5E637" modified="2018-07-18" version="1">MPSVEEDVHDSDRRIFTPPPRIAARFYAEVEPLMAEAQRRREELRNKTAVKRTRGLSVVAKKSSESLPQTKMSDEEAATKIQTWWRGCMRKKILQEFHALGLSVDGIRNTSFDTVVELLAQEKVLMVTARLLRICGLQEGEPGSVEEMAAVRTFLSAFLILGHPDQVLNNMDESAEDREVEAQLSRHRLPATELNNPQLQDLVDKAKDVLISFENILTWLTPANRYTMPPSLQTTLQQAYSVFYNAFIAWKSRDSNALIEVMLMQMVELDAIYHTVKESSDDAAAALYRKSIEDSQTMLIVRIKRLAGAERGKKLFMQAIREARQARKAKKQAGDTKPRVADSDSVSGDAQTTANDFVSSDSQLLTPPSTPASKSQARATTTVKPGLNGLIPDNRVVVHELAINKEYQIPAEEYVEQQAAFSRPLYVQMRAAMGDASDEANFRIFMLRASHIKDKLQRPLKEGNPMYNLIGEILDVDIAQKQFEMGSFSYEKFFSAMASLLPKLCAPFRDEQVKDLVQNKLGDGSVIDRIEALDRFVDVMLCDYINYLLKIAAPQLIESAVPYEAKRFAEELGDEQDNLPVAEAAWRSARDKVMAEVHKRDVEGINHPKSRPTASKIYAQMLVDVFTQPTPVGPEQIPEMLRLDQARINQVSTMVQRIITVGAVLLQCKNLLKRDVRSAWKTEAARVMAVLEANHPSIETAVDGTMAALEAGRSMPAPAKTHLRALVTKVLTASREMTQRRTEPRDPVLRLLLTRLRGNILARLQSGSASEKVKAANTAGEKLASLGLSEFVEKVREMSDLLDKVGAVDRAAHAPWWDMVAAKAQQEDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVH8</accession>
    <name>A0A2T4BVH8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Propionyl-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1339569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVH8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVH8"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="555"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="702" mass="77037" checksum="EDA3CABA367396C3" modified="2018-07-18" version="1">MSGKGGHVQDDILRHSLENPEEFWANQAEHLFWHKKPSTVLKLTSKKLKSGVEHDSWEWFPDGEISTCYNCVDRHVEAGHGDEVAVYFDSPVTQTKEKFTYRQLLDEVEVFAGALREDGVRKGDVVMLYMPMIPAALIGVLAVNRLGAIHSIVFGGFAPNALAQRIDSCKPAVLLTASCGIEGNKPPVPYRPLVEEAFQLAKHKPRRTLVWQREQTRWTPIDRSAGQASWQKVVESARSRGVRAECVPVKSSDPVYIIHTSGTTGSPKGVLRDAGGHAVGLHLSISYLFNIHGPGDVVFTASDIGWVVGHSYIIYAPLLAGAATVIYEGKPVGTPDASAFWRIVEEYKVNTMFTAPTALRAIKRDDPDNKFFTQIGERGGLRTLRALFLAGERSEPSIIAMYQELLNKYAAPSAHVVDNWWSTESGSPMTGRALVPHAAHDRKTEARHDPPHLKPGSAGKAMPGFDIRIVDDEGREVERGTMGNIVLAMPLAPTGFRTLWDDEERFYNGYLKRFQGKWLDTGDSGWIDGEGYIHVMSRNDDVLNVSAHRLSSGGIEQAVTSHPQVAEACVVGIPDALKGQLPFAFITLATTDHPKSAVPDEKLAAEIQALVRKQVGAIASLGGIIQGKGMIPKTRSGKTLRRVLRELLENATRGEFDKDVAVPSTVEDAAVVEVARAKVKEYFDAVGNKHVPIEDHNIKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWP5</accession>
    <name>A0A2T4BWP5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1393630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWP5"/>
    <dbReference type="OrthoDB" id="10647203at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="292" mass="32570" checksum="59A135736022865B" modified="2018-07-18" version="1">MALTPTDQARPKSDRVARIGSNNIASGQGVMNGGRPRPLWARTRGRRSTRIRGWQGCRRAMAEKDHSRASLSWALGTPDWHVQEGGVGKGRDARWEERSSAMLVKRRGLIQAQEPYADKIPNKRQLAVYECSKPGAHIRSYAKAMIQEVGRALPSRTRTTWAKATAMPSLAKQQQQKRESDGKIVATRVKLLEVALYRLSNELSCVGLALWRRLVSTRLVSPFRVWLYPSIRALVLALTWSARASDWILLVVLRESNTTTWSGFGGRRTTGPCIAALQHRLAMKGSAVGKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX99</accession>
    <name>A0A2T4BX99_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1338658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX99"/>
    <dbReference type="OrthoDB" id="3511549at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16558" checksum="406C60938F55C177" modified="2018-07-18" version="1">MSSLLPIITEILPMILPSTTEVTRADQLTPILDNEGRSIRDAAVVGKCDKMCASVLRIPPNSSSPIHHNSEQDAIINAVSGTGTLVVKEGFKGELRHHELKPGDFAFVPAWTEHQVRNDTDQELVWVITQSGPRPVGAILTDWGGKEAKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXE3</accession>
    <name>A0A2T4BXE3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1424493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXE3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXE3"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="537" mass="58997" checksum="45C3C76BC23AF821" modified="2018-07-18" version="1">MAELSSAPVLSTPEDHLFEAAAQAETRSTLSHDALRTTYEIPRTAAEIRQGAWKRVALQFPDHMLVDAPRVVEELRHELEKTTSADEGAEEEKPKSWRICILADTSYSACCVDEIAAEHANADVVVHYGRTCLSPTSRLPVIYVYTSQELDHDAVVAQFTKEFGDKDTKVVIMADLTYQNHVESITNALREQGYSNILATEVIRDPAGVIPNRRIAGDPLDEELLKSHSLFHISDPPASLLLALQSRFASLHVLSVPSPSSPTLDNPTFRTAGLLRRRFARVLTLASAGVVGILVNTLSVSNYLTSIELLRKKIAQAGKKSYTVVVGKLNPAKLANFAEIEGWVVVGCWESGLIEEDAGYWRPVITPFEMEVALMGEETRVWGGEWWGGIEKLKLEDDGPKKEEEANKNDKEGDVTAEDGVEEDADEDESLPPVFDLRTGKLVSHSRPMQLATRSAAQTKKVNGEDGSRTSEALVKRTVGELATINGVASPGAEYLRSQRTWQGLGTDFDEEASTAIEEGRSGIARGYHVGEERARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXT8</accession>
    <name>A0A2T4BXT8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1382173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BXT8"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="158"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1106"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1195"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1233"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1332"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1401"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1444"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1499"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1516"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1526"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1548"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1585"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1617"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1650"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1672"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1734" mass="191514" checksum="1E137BC97BB754BB" modified="2018-07-18" version="1">MAAMASSAAPAPASNLESLPPRPPTPPREAGKESDPTVKTILSRASSSDPQDSLQTPPTANTPTSTDVPASQLMSSRTRKRVVWSAHTEYKDPVDYRSIERLHRSSPISVPSPASKPIKGILKPSPSPNPLVSSGSEFDLVLGQPNMIEMLDSTIKQLAGADRDSKLDAYMTLSRALKASNNLPDRVALQDKMSLFMHFIQRDITSKSDNGALDSSLVNHALTLLATFLHFPAIASTLTSDFGVFIVDHSIRAFEDASSPKDVVRHLMQVIAFQNFSPKVMTSDRVGRLVAALHQIENHLKGKSIVMSRLHIYRRLVKQARLHMVAHSNWLKDMLLDMLSTIKDIRAQAISLGTEAGFALRSEKQLMRKASEIFQTANEDQTYIEYYIKRLQEMLKDKASASAVPQIWSAIILYMRCPLERWQYYNPWLTLVQFAFNSADATTKQEANYAWNRYIYLTLADSKPSPKILGTLCQPLLSQLRRRANPKQLEEAVRLQRTVIGGVCNLYYYAFAPGNDKLSLDSTWEVTVEPILSLLVDLDGKPEIPGDCLMQAGRILTSLLDMVTPRMWRQDRITELPPANPDELPPLDSKWVRRNCDKIFGTARPILSRRFHDLANKESLLYRLWSAFVGAIAAASAKDIKVSEDTAKFFAHTFGLISMVWRTGIPASSSLPASAFLASIRNFIDILVKALGMLPFTEKKLAMTVVDTYESFTAPSQSQGRSNSSGIVRTPLHHLFSMLASAPPGISDDEALSEFFLCVFEPFFQGKPTKARLELTQELLQLLPRDSPSPSGPWLLAAQNLSLSLDKNESAGSLTGSGKLLGPKYRDITSLLERGLDGHHQLPSERWFSLFERLSEHVAQQLGDAGRALVVVEPLAKALLASWEKSDIQKPSTTTLKATRVLFDVAKLPRDQTALNTARQRLWGTSLVAARAGSLDPFDNLYKLGNQVLQTFYSRMSVFDSDGEIVPFMESIEGYLVRSFSQLGVKAVTNFQTGLRFWIEDEKSYHEHDEESLLSKTLIHLWDRTSTKLAGRGRLTKDEFGQMEPLLTAAFKSKLPAIVDTTIELWNVLARDEENLACSDSLKSVASDAGSKKQQLLAKAKNGDAFGAQQPSLDQPPDGSGLVVLSSSSSRLDKQAASSSRATTRLSAQKRRKEETLDTSRTKSTKRTSTPKLRHDNSQVIFAPVPSSSPPPADDSQHLTERQKEVRERQREAEHIYSDMRTSSSPPPEEASPKPAEASVPAESHAGETTPRRGASFDNLISSTPTPRRGQLMQVDDNDPPSSPLVPRPYPLLSEIKSRSRIDNSLDSWEFSSPPGSPGPNGQEAAEAQLPGEKEKPVDKVNDKAKTKSKAVGINYERIIPSSFIEEESSSSDLTDLSDRDASPSPEPPRLPETPTRKRLLRDAVRAEDSPKSGDDEFVDARSTPEKPLVPRGTDTSFALSEGDESRMMRLAEELESGGGPVQDTIEVVADSSDEHSDEPRAPSPPRTRRATKRANSVVIPSTPANPVNDSEGAGSKKKRKRSRSRQSEGRSKKQRSETPKPTKEVETTAASEKASEAAGMETRGSARRHRQQRQLEDSTNKKAAASKKRSTKRNKKRRGGDTDDEAASQLVKETDAAAAESQEASEQADDGVLPSTNEEPHQDSLESIVADVDVVMDDAAGADEPASEPQDAEKGEESKKKDMALTIMETLQNSLEQLRQVALPRNEVYKMEDVLMDLKRELFEAERRGRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYG3</accession>
    <name>A0A2T4BYG3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.1</ecNumber>
            <ecNumber evidence="8">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1337775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="8"/>
    <dbReference type="EC" id="2.7.7.18" evidence="8"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYG3"/>
    <dbReference type="STRING" id="983965.A0A2T4BYG3"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="52"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="290" mass="32055" checksum="5A576A226385FE08" modified="2018-07-18" version="1">MVASASGFGAHPRPNGTPPLPEPILSPPGYTFPRQNLKRRLTQPGKVPLVLVACGSFSPVTTLHLQMFELAEKYVKQSDPGFEIVGNYMSPCSDAYQKASLAPAHHRIQMCSLAVDTDSKATITIDPWETVRTDDSGKPLYSPTVDVLRHFDHEINNVLGGIETVDGKFTSARIMLLIGADLAATMSDPKIWDPADIDVLLGHYGAFVVERPAQCNIEDAIRPLEKYKHNIWVVPTILNEVSSTRVRAQIQNGERAEDIPDSVYKYIKLHRLYQKEPTTNGRPAELTNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYK9</accession>
    <name>A0A2T4BYK9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1381267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYK9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYK9"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="367" mass="41876" checksum="E682B49297FEEAD4" modified="2018-07-18" version="1">MPPSFPVQPVMRFLGASQPVKRPKEIACFSYDENHEFRPDASSMKYYYPPELGVDLSRGFNTFIKHDDSQDEHLDSLLKAIMLHEQETGTRIDAKVVTWRGMMTKILAAPFEKYDGFEMNATLYQNHAHKMLSKQKEPRGNPGRGPPPEVMQFWGYKFETLSTLPAPWAETSRDFIESRETQVVNTKEQYCSIVRTGIGKTVLCLGGEVDAIWDSKPQEKGAPINWVELKTSAEIRHAGDVEAFHRKLMKYWIQSFLLGVPKIIVGFRSRDGVLVDVKEIETQSIPQTVNARPNAPWNADICVNFAAAFLEWLTQIINDEGVWRISRRSAHSPVIEVYKVEETGHGEILTDEFKNWRIKLDLGTSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYL4</accession>
    <name>A0A2T4BYL4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Common component for nitrate reductase and xanthine dehydrogenase protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnxH</name>
        <name evidence="5" type="ORF">M440DRAFT_1338198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYL4"/>
    <dbReference type="STRING" id="983965.A0A2T4BYL4"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000003">
        <property type="entry name" value="Molybdopterin converting factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18288" checksum="BA732407D898E02C" modified="2018-07-18" version="1">MTDTKDDDTNTIWHLSEQGCHVALTHNHLDIQQAIDKVRSPAAGAIVLFAGTTRDNFAGKPVKELQYSAYNKLALRTMLAICKDVQAKHGLKGISMTHRLGTVPIGEESILIAVSSPHRQAAWRAGEEALEACKARVEVWKREEFEGEEGVWRANRDGAVGQKVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYQ2</accession>
    <name>A0A2T4BYQ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1403829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYQ2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYQ2"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:translation initiation factor binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="358" mass="39024" checksum="1CFAD52A421BF16F" modified="2018-07-18" version="1">MAAATERFLHLARPLAHTNIGLQTNIAPLTVQIQPQAVLSILDHAVRRDVRENSQSTRVIGALVGTRSEDGTEVEVRSCFAIPHTEEEDQVEVDVEYQKNMLALVLKASPRESLLGWYTTSHELNSFSALIQNFFAAPDTGTFPHPAIHLTISTEPGKDIETRCYISAPVAVNAERAAESCLFIQVPHKVLYGDAEKSALEAVASARDVESRSAPLVSDIESLGRAIEQTIGLLDRVSEWVNGVLDEDVEPNNALAQYLLSALSLAPKVDASQIEHDFNNHIQDVLMVSYLANTIRTQIDLSQRLATANLVSNEKEEGKGDGEKGGRGGNKRGGRGGGRGGGQQREPREPREPREPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZC3</accession>
    <name>A0A2T4BZC3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1358985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZC3"/>
    <dbReference type="STRING" id="983965.A0A2T4BZC3"/>
    <dbReference type="OrthoDB" id="3946741at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015579817" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="731"/>
        </location>
    </feature>
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        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="911"/>
        </location>
    </feature>
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        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1171" mass="124930" checksum="41C9C6600CAAB451" modified="2018-07-18" version="1">MFLDRMSRRLSSYMLLLFFITLISTATAAPLNSGGIDSFVPSCAAQCFDSFLKISYADRPPRTLAALCPRLGANGFTIGEAAVQCLVAERAAGACSKGDASDAVIDRAFFMCFGQPGAISPTHSVITATLAVPITGTGPITFPPASKTRSTTIPTAIPRQSQSSLSLPPTLVTDPTSLSSLRPSETRSTSVPTTKSASRTRQTSSSGSSTSSTTSAREILTTDPVAPTFTFTSTSATETSTSTDVPDDVSGGQGKKDSSISLSTGQIAGIAIGSIAGVGLIGFGIAVFCRCLRRRSRFGRKWRKGGRPLRDSGSFGTEKGPHGGGGGGGGTDSWITNQLRAPLNPGPVPTPTRSWYNRASWRPSAIGLAISPSHTRDVTRAPTPTSARPLSKLLPAKPVMDRGPPKLEVSLPSRDGDSHFGAATIMGAAAGAASGAAMSGAIPASSSQKPTQPKAEQQHQKPQPLPPSQIHPALREPATAQPSIIRPRNLTPPQSKQPQSPLPLKLLIPKTGNFKPFVPVVTRHDSSTTEFEEDGRISVSPVGQVWRPPSDDPPSAAAPYYVADRSGNWRLGDPARAKEIAELEASVSPLTAAPRSAAPKLVAGLGLATEAAGALALVKAASQRRDNDRAAEAAKASRQQNRQSALGINMAPEKTIRAVEPSLSSDEEIQEREREQQPYAPRPLFSGVSNNNNNSNFPRRSSTHRLSSTRSLTRPRITSTDSGVTTISTSTDDTDLRSPHPPPEQPGSLSPVVESPQALRPREGRSPTQYPKIPASLQVTVPAPPPSAGNARPAQASPSFGAPLAAGTMSSADGNMPRQQQQQGRKLISPRLAQQAPDAIRTGSPMMRSESAPFRPDNSNNNRRYVQPPRSNTLPQQQQDIPSSSRAAPRTYPPQQQQRQPAQFSQRPPSSNNYSKPYRLPPHPTAYRPSIDSSGYPYQTRLSDLNPQTPSTYNLPYPPQTNRYPHHHPRNHQPPFTQQQQRPQPQPQPQRQQLQQRRQQQQQQQPQPQQNLSIQPSSTNPPLQPPLLTTTSATSSSSASTSSSSLLAKRLGPSRAANLSIPVPQSASSSIYSTATTTAANNNNNNNNINSAGSNNNNPSARSKWLRHNSIPFPAASAAQPGEQQTQGRVVDSPKKFPPPPQEPAELPATPVWKPRLTPTRRGDDLFLIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZF2</accession>
    <name>A0A2T4BZF2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1403187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZF2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="10602" checksum="88CD2A1D619D9D46" modified="2018-07-18" version="1">MHRFPFLLGVPAVLGDSGGEITQCVRVVGWTVRHELRDETDGKRSRLHNKLRDGTLMSGLDGTILMTQGPCFGPFTAVPRDFEKQVIASAQLSIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZJ3</accession>
    <name>A0A2T4BZJ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1337205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZJ3"/>
    <dbReference type="STRING" id="983965.A0A2T4BZJ3"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="39565" checksum="BFF728CF73CAE4E4" modified="2018-07-18" version="1">MDKPSQVAAKKPPADSGPPAPGAAAAAASPLGADPAAIEPDDAASSDDAGYESDLASRASTSVCSSVRDYEFENNRRYHRFQEGRYQFPNDDLEQEREDMKHAMVVHLCDGRLHFAPLEDPRRILDVGTGTGIWAIDMGDEYPGAEITGIDLSPIQPQWVPPNVRFMVDDAEADWVIPPDSLDYIHIRHMTSSIRDWPGLLSRAYKALKPGGWIELQDLQFQVKCDDGTVRADNKLQDFFQTMIRALEKFNVDLLAMRHNRQNVLDAGFVDVAETPFKVPVGVWPRDSKMKMIGLYNRSMMLDALHGVAARPFTRGLGWTMEEVEVYLVGVRRDLMDASQHGYTPFHVVVGRKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZP0</accession>
    <name>A0A2T4BZP0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZP0"/>
    <dbReference type="STRING" id="983965.A0A2T4BZP0"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="235" mass="25863" checksum="A871C99126958169" modified="2018-07-18" version="1">MVLTHSTNHTYSHPFPTVTLAYFLRYSSPQLNPFAAHVLSTDTISSHVDPETQRLYTTRIHLKKSRMPGAVYKLLPASVSGGSSSGEKASYILETSVVDIKEGWMKTESRNLNFTGVLSVVEKQHFKVPSSPEAVARNETDVNSSVMFKSRLGDKIRGKIGQAQESSGWLPGFLGGLGAKGIQRSIESLASTKTIDQLSKSRDGMRLVLERLRNGGVIGVMEKLRQERQRQAAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C041</accession>
    <name>A0A2T4C041_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1359539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C041"/>
    <dbReference type="STRING" id="983965.A0A2T4C041"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015574382" evidence="2">
        <location>
            <begin position="20"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="4">
        <location>
            <begin position="150"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="3">
        <location>
            <begin position="343"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="736" mass="78592" checksum="B06BB0F1AE4855EB" modified="2018-07-18" version="1">MGWLSRLSAAAALATTALAAEASTSSKSSSAAEPCAQIAKLVKSGAHSFSSQLGLACLQSIPFKSDLAVSFVDEYRKYLEWQSTTEILRNPPPTAISATVDLFGGLANIRDRASANLYKSQYDFDTDLFHLLSFANDGHLAILPCSLVFNFQSPLRLASLSSDGIEVPRLYTLGDGKLLAQGNKDVSPVTLINGVGAEAFTEQLSEVQGLQDPDARYNHMLANVPIARDGSELSGAYGAFRTFPGAHEFNLTYANGTQQSLPLTAVIGQLDTDFTYQTGDELWDAACKPRPASSDDSSQKKRAESSPSTKEKPAPETYPKPTVKDPFNLINGYLLDDKGLEDVAVLTVPTFETEDEASGIPINEIANFALEAQEFVQKAVAAGRSKIIIDVTNNGGGVVASGFGLVSVFFPNMTIFSATRIRSNPGYQFIVETISRFPGAGEDPGVAQSGFFVPGLVKPDQKSTFGSVEEYLGPYDVLGVPSTAIVAENNFIFTNETLNPINIFGQGGVLNGTTPPFAPENIVILTDGRCSSTCTIFVNHMIPYGVRVVTTGGRPQAGPMQGIGGVKGSQVLPLNQISGLFSDAQSLAQNASDSKKPLFTDKEMSVFSPHIPLPLEELPLRLTTASVNFRNAFSPFDDQTPTQFVYQAADCRLFYTAETLIKPETLWVNAADSIWGDGDCVFRSVPRKAIKSAGTKTDSSKAATTSATPAPKKKKTRAPAHKALGLLLAMAEGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C079</accession>
    <name>A0A2T4C079_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1403395</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C079"/>
    <dbReference type="STRING" id="983965.A0A2T4C079"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB74916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="41349" checksum="17C935512AEA2B14" modified="2018-07-18" version="1">MSASNPELLEQPQGEPAPELLDGRIWVDGCWDFFHHGHAGAMVQARQLGDELYVGVHSDEAILANKGPTVMNLEERLAATDACRWVTKSVGYAPYVTQLPYISHYGCRYVVHGDDITSDSDGNDCYRFVKEAGRFKVVKRSPGISTTDLVGRMLLCTKTHFIKSLKKTLAGEEGVGTPEERKAQAEAMLERIKLYATDESVARGLRSWSADYGPAYVVAGVHEDRVINEWKGVNYPIMNIYERGLCVLQCKYINAVVFGAPFTPTKSYLTDSPWGVPDAVYHGPTAFMPLTYDPYTAPKEMGIYRQIGEHTFSHVNAGEIVQRIMKSRDMYEARQRAKGVKAEVEAAARAREQLEEEQRKKEAQRGVMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0H4</accession>
    <name>A0A2T4C0H4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1392535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0H4"/>
    <dbReference type="STRING" id="983965.A0A2T4C0H4"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000364">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="232"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1077" mass="116916" checksum="B665A3912983898F" modified="2018-07-18" version="1">MAHAPLLRTNTAPVFQSHPNGVGALPPQQSMSSSAPRTSQLSGSTYAGSSTSLTTLNSDMTVVANGPVVATSNIINQKADASRSLYQICISLKQRLAQVPGFEPFLANLDPTDPVDPLWNLFRSGYPLLVIYNSLQPAEPLSVDDANASDSKKSKIAIFKFVQACMKELQVPPSDSFVITDLMGNDTSGFVKVTQVVNYVLDLAEQRGHLLQLQPYPDGEPVEAGDGPKMTYRDHVVKELVDTERKYVQDLENLHDLKKALEQKGVIPGDVVHQIFLNINSILDFQRRFLIRVETTNSMPAAIQRWGQPFVTHEEFFSIYQPFIANQRKAAQVAKEVFDQIQLSDHPVAADFNTLDGFLLKPMQRLVKYPLLLKDLAKKTEEAETKEDLLAGCEAAERVLQKANEAVNRDLLDDALEELIVRVDDWKSHKIESFGKLLLHGVYGVITGKSEQEKDYEIYLFECILLCCKEISPNKSKDKKDKTRQQGPKTKNKNAKLQLKGRIFMTNVTDVVSLSKPGSHSVQIWWKGDPGVENFTIKFLTEEMMKKWANGLETQRKENAPRLAASPADDPTDFAWTRDNAGGLENPYLQQEDDDDDDLGPATAPAQFPMPASSFGGAMPRTASSSNLRELRQRSVTAETSATLASIARAPPPRFPMAMPPPPPVAPLSLQTASSMSIPSPGIRGGDSYFSPIGDSPASSRTSTTSGMFPPTSYPFPKSGTPQPGWDENNRYTAPAMPRAPSRDGTPPNAYPNGRNPRGPSMPPMSTQSGNHSLSSLNNLNNNLNNLSLKESNAAAAAAAANGSQRSRSYSTPDGTVQGQRRQPSQSNIPAVPGIPLHLHPAHDSSIPRSQTGSPRNDAPGRTNTQSPGAQGVRVHKHSHSGSMGGSVGGTMAQFPTQPIYPRQNTPGPAIGANGTAGSRTVSPSAALSQGMLAHHGMIPQGMMPSTMGAGIPNMPGMPQNPTQSSSLGSPDVAMPTQLKVRVTCDTGNYITLVVAFNITYQSLVDRIDAKLARFTSSSIAQGSLKLRYQDEDEDFVTIESDDDIQIAFMEFRDGMKNAFNSGVGEIELFCVGEMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0P8</accession>
    <name>A0A2T4C0P8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0P8"/>
    <dbReference type="OrthoDB" id="4894216at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="106" mass="12233" checksum="F9C52C1F6727989A" modified="2018-07-18" version="1">MSNKITDARLEWLEETRRRKSLLLQKLEEEEQKMVTDKDGAAADDAAAAAAALADRQQQQELDEQQREALNTYQLNIDRYKEELAAIEKEFESWQEMGFSLPASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0W3</accession>
    <name>A0A2T4C0W3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1402754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0W3"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="257"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="448" mass="48235" checksum="E7C085F8635F3121" modified="2018-07-18" version="1">MDKENETASDSVAEDNAFIESKQTMPRDLTSHDEAPSTSPPPASSIAVPDGGLNAWLQILGGWVVMAATWGLINAFGAFQTYYQTVMLTSESASTISWIGSLQACLLFLGGFVAGPLFDAGYVTSPLIGGLLLICFGMFMTSLCTTYCQVLLAQGVCVGFGMGLTFLPSTAIQSQYFQKRRAFAMGVAGTGSPVGGIIFPIIFSHLLPKIGFGWTTRVIAFVILALCVIPVVFMRPRVLASGRIRSLVDNSAWRDLSFMSFIVGSVLNFLVLYTAFFYLQVYDELNHLSSLEFAPYTVTLLNFGSIFGRLLPMYLSDKYGVLNVMIFSTFASGILAFGWMGIKSLSGIVVFAILYGITSGATVTGVPVVIMTQTSDVSRVGTRLGMAFVFFGIAILIGTPIAGAIFGDFTHTRWLGGIGYSAGGLILGTVFMCVAWFPLRERKGTWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C152</accession>
    <name>A0A2T4C152_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRPBCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1402831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C152"/>
    <dbReference type="STRING" id="983965.A0A2T4C152"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16935" checksum="2F499E9523559F4E" modified="2018-07-18" version="1">MSPILSVSTKIEIAASPAVVRSVFLDFARYTQWQPGWNIQPADASKQPLDLKAGDNLKVNMNGNVHHPVVVENSPDSFQWEGSLFGLAKGVHQFHFTPSETTPGSTTFTQGEDFRGLLITLSSPWWNSRKFDTGPWDKFNADLKNEVEQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C183</accession>
    <name>A0A2T4C183_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1423386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C183"/>
    <dbReference type="STRING" id="983965.A0A2T4C183"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="180"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="417" mass="46641" checksum="AB417A80EA9FD3D7" modified="2018-07-18" version="1">MSALEDLLAEFTLVLQDATAKLRGPLNDERISTLTPSETLPENNKKLWDLLAQTVNMADQIVHLLQPPAIRLAETYLAYLDTKALVTAVTHNIPDLITQTALPTPLLAQKANLQPLRLAQIMRTLHHNSNIFAYDPKTDTYSHNEASLLLQSDHWTQWHHWVTLYGEEFYDAARAIPQAVTQGESRSAAQIAYGTEKPIFAYFAERGLQEKFHKALGAGAVAQAPGMLADYNWAELGDAVVCDIGAGGGDFIASLLRKNPRMRGAVLEIQPVVDMIQQKLEQPDGSFNDIADRLTQLHAGDFLAAVPPYEVYTMKWCLHNWTDADVLKILANVRRAIKLTPRARMVVIESVLKPGRSSRVWRYGDLTMMSTANGLERTEEEWRRLAGQAGWVVKDIVPLRHAWASAIDLRPFFTVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C193</accession>
    <name>A0A2T4C193_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1439880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C193"/>
    <dbReference type="STRING" id="983965.A0A2T4C193"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF32">
        <property type="entry name" value="AMINOTRANSFERASE GLII-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="71"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="446" mass="49879" checksum="07C97FAEA9AE6632" modified="2018-07-18" version="1">MLSRRATEKNAWFLEQFKRPLARQGSKDASNIDMATAENWLLRPEVLSMLKRNCVAGLREEHLSYASGLGGTSELLESLSRFFNHFFSPSVPVRPEHIVTGTGCSAVLDTLINDICDEGDGLLVTAPMWGDFQVSAVLRNSVQLIPVYVSPEQSHSAGDIVQAYRDAAAKATCNVRGILFCNPHNPYGHICPTEAIDGLLQYCEEENLHFVSDEIYALSTFGDLEGSSEGNKDVYRSPETRFVSVLSRDLRLLGVEQARVHVLYSISKDFGCSGMRLGCLVSQDNKPLRTSQAILNNAKICNAGTIMVTPMFSDTAGLERLVNLNTQRLRTAAQMAIRFAEFHGLSYYKPVAGLYVWLRLSDDCSTFDEEEALVQRCSQRGVFVGSGADYSEPQPGWFRLTFALPEEKLLEGLRRIEEAMGYEKVFTTREQDFHVRLTNWWRGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1P2</accession>
    <name>A0A2T4C1P2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1P2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015475131" evidence="1">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="60" mass="6266" checksum="DACF63CB6805B46F" modified="2018-07-18" version="1">MQLRILLAVFIGVASAATLQATDCDCFVACDSDLHDPGNCYNNFPGCTDTCCGLCGCNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1W3</accession>
    <name>A0A2T4C1W3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1W3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8542" checksum="C62F40E85BFC98B6" modified="2018-07-18" version="1">MQDRVASPPQTAKPHPSKTSPNQQNNPIRITRIPSSTKSMLALQPTFPPFAIAQRLQTHPACITNSHSSPPPHHFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C245</accession>
    <name>A0A2T4C245_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1334898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C245"/>
    <dbReference type="STRING" id="983965.A0A2T4C245"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015418237" description="Arylsulfotransferase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="66449" checksum="A07B17BCACEC31AC" modified="2018-07-18" version="1">MLTLLPTLLTLLLFLSPFSLADIPPLTNSSEFTTLTTSYANFPSQTFRSSPLTAPIFLLNRLDASRASNASHIFLGTVYGTNKAGPMVFDARDLSLVYADQRYENTYASNVYTINGTRFLAFWEGGHTRGHANGNCLFFDEAYTLRYNVTAQGLNDAMADMHELSVTETGTVIFSTYFNIPFDCRPVGGPEDALLMDSGFQEIDLATGELSTPQTQTEQGDYLVSARHLSILTLIDHKTGQPLWILGGKQNQFTDLSGGAATNFSWQHDARIVPSTTPSPSPLTEAQAQQETHITLFDNHGEESGFCSTQQCATRALRIAINPTLHTARLVSQFFHPEGVNSGAMGGYQTLSNGNVMTAWGYNPSFVEYAPDGTPVLDVQRGPIGGEEAVPDMFAYRVHKGDWVGQPPWPPSIAVDAPNNNTYNATIYVSWNGATEVSSWAIFASNDHKTINNHTNLIIQSPRQGFETSISLPSTSTSTKTNTTRRYVAAAAVSSSGDVLGSTIVLDLQDGGNPITVTSDIVSLKPPAPPPVPSPSASASASASASASPSKVAPVAASTSASASTSAERQTTSTSTVGVMGASIFSVAGVAYVASYFWRRRRLGHSHQEGYRMVNLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2I2</accession>
    <name>A0A2T4C2I2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1470656</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2I2"/>
    <dbReference type="STRING" id="983965.A0A2T4C2I2"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB75708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="246" mass="27284" checksum="87B0312ADB66CFEF" modified="2018-07-18" version="1">MGESRQELLNWLNSLLQLNMTKVEQCGTGAALCQVFDSIFLDVPMSKVKFNVSGDYAYIQNFKILQNTFLKHQIDKNIPVEQLVKCKMQDNLEFLQWTKKFWDLNFPDHDYDAVARRKGAGVVAPANTGAPRATVSSAGARRAGGGTTPSTGPRVAKAAPGPGTAALQAEIGTLKETVSGLERERDFYFSKLRDIELLIQQAVEEDPELEKQEDGLVKHIQTILYSTEEGFEIPAEAEGLDDQETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2I3</accession>
    <name>A0A2T4C2I3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_329082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015574383" evidence="2">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="16845" checksum="D656BFEA9D34AB89" modified="2018-07-18" version="1">MVWSTCRWAVALSIRSICTLCAHRLFLYGAVGAGRLDGQSSEAAAVLSRSSWLGRPCVCDECCAALCRNQWLGSCICTNNVRYGSWLAEQPLKTRAWETAIRREALRKDLSDLDKLARQRTSAWPLRGLKGPPPSMASKQASPPATPLVLTAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C383</accession>
    <name>A0A2T4C383_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1333611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C383"/>
    <dbReference type="STRING" id="983965.A0A2T4C383"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="28608" checksum="46DF04C3F7251391" modified="2018-07-18" version="1">MARPPAMFHAFLRPSILQILRATGYHSTRPAVLDTLTDIAARYLTLLCEKAAGNAVNNHGDAGDYDVVDVRMALQEVGALLPDRTWRRGDDGDEDMRGVEEFIGWFAGPRMREMMEMGSGDTESDATDYLAALKKKHSKTGDDAKWQGTIFGKSTDGNEILVEGGPITSISEWISQRAPEPRHPPRESTEEELEQEPEQEHEHEEQQQETEKEKEKEKEKEKDGDKPEATAGPGRSPSSGLSSVGDRLGGDAAEDMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3B1</accession>
    <name>A0A2T4C3B1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_4576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3B1"/>
    <dbReference type="STRING" id="983965.A0A2T4C3B1"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19717" checksum="D53D8DE15F534FE9" modified="2018-07-18" version="1" fragment="single">LLSSAPGLVALHWGPHAESPTTLTYVARWSSDESRQAFFHTRSPSWHSSFSEHLSSLVVLESSASPQDAVPALEAPCTEIFVSYGAENDFLEKRLQPFVQAVTGANPPGLVGAYAGEFVAVRQFGVPPPKPKIAVMLLGWNSREDHDAQKQEGKVIANNIHLIRSGRESASGFHVNFTKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3E8</accession>
    <name>A0A2T4C3E8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1422234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3E8"/>
    <dbReference type="STRING" id="983965.A0A2T4C3E8"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015568940" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB76090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="23363" checksum="055CAA9A41071273" modified="2018-07-18" version="1">MLLLSAARTFLAAAAAIQAVTAHNIVLPARGVECFHESLHRDDKMTVTFQVGDREFGSAGNLDIDFWIMNPVGEYQINERTVSNGDHSFTAVHDGKYTYCFGNQHWVSNTKEVSFNVHGIVYVSESDSPSDPLESEVRRLSELLAQIKDEQQYIVVRERTHRNTAESTNSRVKWWNLFVIGIVIGESLFQVWWLRRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Q9</accession>
    <name>A0A2T4C3Q9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1377100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Q9"/>
    <dbReference type="STRING" id="983965.A0A2T4C3Q9"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="227" mass="25875" checksum="20B981F56650E6AA" modified="2018-07-18" version="1">MILKPIKLYWRNHVPNPAKVLIILEELNLPYETSWVELDGLKQQPYTDVNPNGRVPAIEDPNSGITLWESGAIVQYLIDTYDKDNKISYSSFPEKYLTVQWAYFQASGQGPYFGQAAWFNLFHESTYGDSPESAKIRYGNEVKRIASVLDSALAKSTWLVGDKCTYADLAFTMWNMQIAFFMAGRTGEHAWDANAFPHFTRWQDACLARESVRKVVGVLGERDVRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3U9</accession>
    <name>A0A2T4C3U9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate esterase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1463002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C3U9"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015550674" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="3">
        <location>
            <begin position="93"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1341" mass="145660" checksum="A778103BBB92E1DC" modified="2018-07-18" version="1">MRYLLKALLGLYAATSLVVADSDHADGISPFGDGFGPDVTVDPSWNDTAPSFEGVLAPDLDGEGVATANDTEPDIGTLYRRAAKDFYLRVMPLGASITQGQASTDGNGYRKWLREQLRWKGWKVNMVGSKMDGNMADRDNEGWPGWIITQVQGAFDASKWMMPNLVLLNVGTNDCGGNVDTGNAGGRLKTLIDDIFQSIPGVTVIVSTLVPSRDYNACASSVSEQYRNLVKQYSGARIGLADINSAMPMSLLSGDGTHPNDDGYKLFAAVWWDAIRKLEDQIQPPASVSLIDDNAVGSTKTCAKVAGTARGPIQSQQGSGHDDGNYVHNRVEKGALKSARIDKFDDPKNITDNIPWHMFFANLVVGDPNAARSAALDDWIRVYHDTRTNNNTYYFRQNLGGGNFGPSTTFDVDQNCDGGPLYAFADFNNDGLDDFYCLKSGSAVAVSINKGGNPPKFESLGQVVGTHDGYTEKDVRIGDVDGDGRADYCLTQPDATLICSRNGGTDDKYQWQGFSTATGLRGMVFNGKKGDPAGVVLGDLNGDFRSDYLYVGDNGNVETWINSRGWGKGIVPSWRSAGLTHPGQADTGIRGQIKFGRIYGSGRLDYIYLDEDDTGYDVKVWQNTGSGGTRRKADGNYYCDMRGTGADDYVWIYADGHAAEINSNIHNLPLWGHSTTISLSVPGPRVGIHLADWTGDGKCDVLVQNKATGALTLYENQYNAGKNSLTFANRGVVTGAVCSQGWGVGIFDLGMRLADIDGDKRADVLCLEKNGRVTAWLNTASGLIDVGQVKYSEGWDRANMRFADVEGSGRADLIHLDKYTGAGTVFKNNGPGAGGGGSSFSWKDRGVLYAPIDRGETMHFTNQGGLGRADLLHVLPLTNRAWTYFNECGGSGGDDTSVADPGLPAYGDGDATWKNSGAEKWFRSFLDDHGAENWSSKFFKAATAGGIQGGSTYDCTHMNSGNCPGPLGTACVTYNPPSAFFVHIQMGNLYSAYERLWFNMITDGITELSSGIKDIVSKWGTPPKEDNEAIIDMLVGILKSILGGVTEKDAALSGPLDFFGEVMDEITKVDPPDPSELEDELDIAYGSWFTGVMHGFNDSSNRVFSGAKPDDYDGSAEDWVWTRFQHGQWLDSDVVGKVVDEYSKSVQNKFKEYAAVTAMKTGNSGFDYFLIASSDETTCRNGTDNDWTGLIDYPINEGICKLMGTNGACIWYDNRCVCFGRRDNGVGHIGTIAYPLADEALDDFKDYVEDIGDALRNNYDCVKQIVNNWDACRGTLHPPDWCDIPDTELPDTSDFDPSLISPLIYTKCWYNFYPLTGEDFGGCGFRTDCEGGAEYFRGEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Y1</accession>
    <name>A0A2T4C3Y1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1401698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Y1"/>
    <dbReference type="STRING" id="983965.A0A2T4C3Y1"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="384" mass="41006" checksum="554D48AD44032EC4" modified="2018-07-18" version="1">MGINNPLPASMASECKKCAKILSSFINPRQAFGPDKVIPPSILSNAKGLAIITVFKAGFLGSGRFGSGLVVARLPDGTWSAPSAIGTLGGGFGGQIGFELTDFVFILNDTSAVKTFAQAGSITLGGNVSLAAGPVGRNAEAAGAASLKSLSGIFSYSKTKGLFAGVSLEGSAIIERRDANEKLYGTRYTAQQLLTGTVPPPPQAAPLMNILNSRVFSGMRLGSSDDTMYNDMPVYDDNHDDVVWEGRQGSAYGEGQPNPRSRSNTWQDDVYDRQEFSAPTRSNTFGARGLDSDYRFQDKPIEKKVGPGRPTAPKPVFGAKQATLKSNEAVALFNFEADQPGDLGFKKGDIITVLKKTDSDNDWWTGQIGQRHGIFPSNYVKMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4E5</accession>
    <name>A0A2T4C4E5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1470381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4E5"/>
    <dbReference type="STRING" id="983965.A0A2T4C4E5"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="306" mass="34664" checksum="F832BFF3BA96DB74" modified="2018-07-18" version="1">MMAMENPFRPSLSDVLVVRAMLAQAVILPELVGTILDYAEYWVRSCSKARLNESIYAVRVGDGEFDYQGSKFLLRSFPIGLTENAIHREEEGDRESSDSDSDSDSSISNRHSYETATIPPVPIGKACDREYFQNLIRNTSTQPHPGWTTDDQSPGPFIVAKTWFDAGIERFDASHSCDQCTDMKRLPLCKLRTIEPEIVKATRDNMPSWNDYARTPWRGPREIQRNAMAVGDSRTYVTTWTCRDVYAPDSDEARKWMEEGKGKMNGDGSFVRSLGLGDVVTVWGRAMHRGWVNVVESVEIEVYWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4P6</accession>
    <name>A0A2T4C4P6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 64 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1422603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4P6"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase 64" evidence="5">
        <location>
            <begin position="87"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="350" mass="39556" checksum="949835879A6F28DF" modified="2018-07-18" version="1">MVSFLRLRRSTTILLALTLSVVTFVLLASPLSPVADSAGISLSVQSTGAGPRYPLCSDQSSANVTWPLQSWRAAAESKYGGLLEDKFTIVMSTFHRPRELHRTLTALLATKIPSLHEVVIIWNNFDEKTPDPFVSQHGVPVRYRKPTRDSLNEKLWPDPEYRTKAILLSDDDVYYRPDDLEFVFQMWRKFGKDRMTGALARCASALPSGDWDYNFCSQKKHQDVYSMVLTNLAFTHIAFLDYYFSDDPAVTKIRKYVDDAFNCEDIGLNFVVSMLTGSGPLLVRGSSQYINLDPSGGISRQTGHMEARSKCLNVFAEAFQCMPLVNETGRIEHGVKHNVWYKSVWNRIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5A0</accession>
    <name>A0A2T4C5A0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1430501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5A0"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="227" mass="24958" checksum="A604A210C69D2213" modified="2018-07-18" version="1">MALIVCTPSEADAPAISDVHLRAMDANLLTHAQFPSPEGLRFFHGWLARDTVGHLRDGGSSKGVLVAREEGTGRVVSFVKWLVHRPGRDEGKKGEEEEEWPDVARREYLDPYAELTGRVREGVLGRGAAYYHPTYLCTDPSFAGRGAATLLLKRVQNLAAAEGLPVVLEATMNAVGFYEKMGFEVRNELSMMLPRRGASEATEVYEERCMVWVPGRGDGGRDEVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5D6</accession>
    <name>A0A2T4C5D6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1331719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5D6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5D6"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000178">
        <property type="entry name" value="Glycoside hydrolase family 16 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF62">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="150"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="483" mass="53422" checksum="0267D65529E31804" modified="2018-07-18" version="1">MEQNYYGRPPVIPSAATSSAPTPLRPGTPNTDASRNVHDNTDSGSNVPGAGTNPFVSPDASRPASSFESSSGSPYEEPAEAPGGQRYFHSRLVKKGEIEKPWLDKTDPKEKWVTILPLLGILLGLCISGFLVWDGLRSVVKHKYCPVLDEDFSSGLDPSIWTKEVQVGGFGNGEFEQTTGGDENVFIGDNGHLMIKATLQDANLVEKNNVINLLKDGTCTSKDYYSCVAATNTTAGNSTIVPPTLSGRINTKKGATIKYGRVEVTAKLPVGDWLWPAIWMLPVKDTYGPWPSSGEIDIMESRGNNHTYAQGGNNIASSALHWGPDPANDAWWKTNNKRKSLHTTYSNGFNTFGLEWSQKYLFTYVNSRLLQVTYTNFNKPMWKRGGFPDSTSNGTRLVDIWSQTGRDNTPFDQEFYLILNLAVGGTNGWFEDGMSGKPWLDHSPNAKKDFWEARDSWYPTWTQPQLEVSRVLITQQCDGDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5E8</accession>
    <name>A0A2T4C5E8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1332176</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5E8"/>
    <dbReference type="STRING" id="983965.A0A2T4C5E8"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="79"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="269" mass="29947" checksum="957AAD68FBABBB2B" modified="2018-07-18" version="1">MANRSGKLKGILKDSITPSDSKQTAREIAIHHATLLQQRKDLEAQILDSVILLSEYPLVREAPYSSANPAPSDVSDFKANVRLFQPSDYDDLIEERNVNELCGYTLCSRPRRQTGGGGEWKITSSGEIVKRKELEKWCSQICARRALFVKVQLNETAAWERAGIPDIQIDLLDEDKSTETEADRTARKLGELKLDDQRQAARDSAALAMERGVNGITSSMDKVKITLKEKDVAAPSEMVSQLGNTNTEDHLLVDGHRAKIPEEDTKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Q9</accession>
    <name>A0A2T4C5Q9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1401208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Q9"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Q9"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="409"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="498" mass="52404" checksum="531BE24B1B0C3AFF" modified="2018-07-18" version="1">MSASNHPEDELDDNLLDAEEVGEEVVNGADQHGHDEDHEMDSDEEEEELELQNDSIAYFDLPQDSLFSVAQHPVWGSLVAVGGSAGQEDEAPGAGWIFDISSAPSRPVLPPSYASGAVSDPQTTRLDSLFSLEGHTDSITSLTWTLPQGEVLISAGLDGRVKAWKTDVQPPIGIKVTPLGEAQEVDEINWVAACPSPSHPNTIALGAKDGSVWVYTIDPSDPSNALQIVQSYFLHGGPCTAGAWTHDGQLLATVSEDGSLYVWDVWGFAATQGLTNDNGMTIVSLTAEDQRFEVLGGLYSIAIDPRDTFLAVGGGDGSIKVVSLPRLGDAAPARTNARGGRNARSGAEATAGGQILASLQNHTDSVETLSISVASTSPLTVLLAAGSVDGGITVFDATRSFSIRKHLVAAHNEFPVVKVEFIPNTWVLTSCGMDGVVRRWDIRASGTTDASSSGLLREWKGHRGDGDGGGVMDFVQGGTGQRVVTAGDDGISLVFEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6R2</accession>
    <name>A0A2T4C6R2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1207838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6R2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6R2"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="342"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="504" mass="55151" checksum="487CE6E1877DF478" modified="2018-07-18" version="1">MFDEARQQAEPSLSAATGTSCPSAFASDKPLSAVPMQTSHYMNMSGMKYESAKLPGRIESVTADDWMLHQMTKPERPQMRSPTASSGYAAELSSSSSSQPRLQHGFGAQDSPADRPHRHRRTESAASIASAASIADINIDETRTDTGVTVEEIAQYIQGPETTDGKWTCLFEDCGKQFGRKENIKSHVQTHLNDRQYQCPACMKCFVRQHDLKRHAKIHTGIKPYPCDCGNKFARHDALTRHRQRGMCVGAFDGIVRKTVKRGRPKKNRPELDARLEKSSRTRKKNMSISSISSFSGYSDISNTNSPNYELDVLNEVLDVEIDGETEPLHSISSAPMPSLPNPTVNGSPSNPGNPSNPSNHSVVASPSEASVSSYVSPEAIMDRASHPSSPGKSTPSHYNTPPGLSQSSSSPPSSHFFELDPATSTATEDVVSYSSGGMMMNMSTMAPPLPLSIGEHEDDLLRQFTNDDSFIPLDRDQSLMMMPKFDEFNGVAVGMLNDNGYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6R9</accession>
    <name>A0A2T4C6R9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1455068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6R9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6R9"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="232" mass="25648" checksum="EC382EA92228AFE4" modified="2018-07-18" version="1">MSLPRSAISRLGLVRRSTALSSTITTNPQEEQWPQRTPLGSYYETIHDHPTAYTSPKPPKKTPSPSSADKKKAVDDKSAAKTFSTLKPASTSPESRARVIFGSRLLGPAEEADRLALKKAKSTYVAGVLIPPRPEEPDNCCMSGCVNCVWDRYREDLEEWTAAKAEANARLRAGSRTMDADGGGSETAWTTNISKDMWDEEALKKVPVGIREFMKQEKRLKERHQREGTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6W9</accession>
    <name>A0A2T4C6W9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1437840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6W9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6W9"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="734" mass="80487" checksum="880B8CEA69DE20B5" modified="2018-07-18" version="1">MAVNRIRGAFAAPRKGETFELRAGLVSQYAYERKESIQKTIMAMTLGKDVSALFPDVLKNIATSDLDQKKLVYLYLMNYAKTHPDLCILAVNTFVQDSEDPNPLVRALAIRTMGCIRVDKMVDYMEEPLRKTLRDESPYVRKTAAICVAKLFDLNPAMCIENGFIESLQEMIGDPNPMVVANSVQALAEISETAPETRALLVTPPVLKKLLMAMNECTEWGRITILTVLADYAATDVKESEHICERVIPQFQHVNPSVVLAAVKVVFIHMKSINPELVRSYLKKMAPPLVTLVASAPEVQYVALRNIDLLLQAKPDILSKELRVFFCKYNDPPYVKMQKLEIMVRIANEKNYEQLLSELKEYALEVDMDFVRRAIKAIGQVAIKIEEASGKCVQALEDLLATKVNYVVQEVVVVIKDILRKYPGYEGVIPSLCNYIDELDEANARGSLIWIVGEYAEKISNAEEILEGFVDTFLEEFTQTQLQILTAVVKLFLKKPSGAQGLVQKVLQEATTNNDNPDIRDRAYVYWRLLSGDLEVAKTIVLSQKPTISTTMTSLPAALLEQLLSELSTLASVYHKPPEAFVGKGRFGADEIQRAAIQEQRQNAAENPIAASVAAAANGSSVSQNNIENLLDIDFDGAAPASQEQNSAAGTPDRVSSPATGGMADMMSMFDAPPAGSSGGAPSGGMNDLMNGFEGLNFGATSTNQPLPAAMQLHNAQGGGSQPNKDSDDLLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Q1</accession>
    <name>A0A2T4C7Q1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1216769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Q1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7Q1"/>
    <dbReference type="OrthoDB" id="5335210at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1041" mass="111193" checksum="01E095C7DB529D44" modified="2018-07-18" version="1">MNVFRNKKKGKDEAESARPSMESESSSPFRMFGKKKGQNEEAKPELDISSALPSTDDFRTSLLMTGLSARFSMLREQDDPTTKVGKASDDSVLFPRGQSNWNLGGLQDIAEVESIRSPSISRLEPFNIDDSGSVLNRAKPVDGNTLFGGRQKVYRLPANGAGAGKDGPMSSRTLLEDDVGMSAFQKWRLAEKERQMAEGGDSSSYEAADLEPRSESQSEPLQESQSELLSESRSETSRRRETSSTVSSAAARYSTATSVTSQGAPSVRDSQFTSSTSSSSAERSVLRTRRLYEQGLSRDIQDQQSSAMSRMDHLSKGRPFASALPDGVSPTASVFGDRILERRPILAKASAPNLRSLTPSATNSAAASPSETGSKFPAAGLSKTNFAVAPISPPMSEPEEHPMLAIQPNDRGKATAMGVFERPAEKYDDSTYAQRQLQLQQGRDTPVNRHRSMESSISATSDLKSSSTTQPDKVDPVAAKAVAPEDPPSFFDDSEDDSSMLSGVLNSIKSPNPSLSVERPNDGDHPAFKGSATPAPLSLGPRGLAGSLSAAPSPVPAAPLDSPTLGPTTGLSGMVRAHLRSDSNASSIYPMPEEDSEPARAQSGPSLDHDRSAGSARSTTHGRPPMSRSPSRPRASNEDEQKEEDAFARHLADGARRVREKLGSMVDAEMDRPSPMTPSASESTRDAPPSRTNALGILKSKSSHTSLFDRHARDQSQPRSMKMVMSSASNGSLPPSRRGSTEAADDSRRGRSTQARERPSDEGASTDKEDNVHVGLKAFRQARLELQKMKDLDTAQRPSERPPLSARLASHDAVGPPPSMFNRKARDESRHGSNSRATSRAGSRAPSERERSGSETSNTGPPPLRPMRLRNGSNAYDDQYMPVSPPGSTRSASGMRHGPPSARQRPPYEAGQPSPMASPVGMGTRSRNGSLLGATASTPNLLSNPAAPPLPPINPRRKTLGRGSEDGMPSPRVPGGFPGGFPGLDESDDDTLAQRRQKLRKATSEGNSLRSRNVPPPPSNGVRPPMPQGSIPGSGLPGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8F2</accession>
    <name>A0A2T4C8F2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1421585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8F2"/>
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="568" mass="60186" checksum="CD015CB5F1254199" modified="2018-07-18" version="1">MDRIPPGNEGAAGAEDSAIRQTSSPSSSPAPRRNPFRKTADSRVQDAQVAASILLANADGARGGDATSLTASTGRGARGTGPQAVLARLRHVLMTFGKFVGPGFMVSVAYIDPGNYSTDIAAGSSYRFKLLFVVLLSNLFAILLQSLAIQLGTVTGLDLASACRAYLPRWLNYFLYVLAEVAIIATDIAEVIGTAIALNLLIPKLPLVAGCALSILDVMAILVFYRPDGSMKGLRVFEFFVLLLVLGVVICFCIQLSLIKHTSVGEVLKGYIPSGAIVQSNGLYQACGILGATVMPHSLYLGSGIVKPRLRDYDEKHGLMPPEQQQPTSSAASSTIDGSYDKLVYVPSLAAIKHCLKYSITELALSLFTFALFVNSSILIVAGASLYGNPDALDTDIFGIHKLLSRSISSGAGTIFALALLLSGISAGIVCTIAGQMVSEGALRWKMKPWLRRLITRSISITPSIIIAGAVGQRGLDTALNASQVVLSTVLPFVTFPLIYFTARSRFMMVRPGGARLHVESREDGQPAGEPGTDMSNGWVLIIISALVWLLIAVMNVANLVLLGLGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8X8</accession>
    <name>A0A2T4C8X8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_64739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8X8"/>
    <dbReference type="STRING" id="983965.A0A2T4C8X8"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13316">
        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11886">
        <property type="entry name" value="SH3_BOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035551">
        <property type="entry name" value="Boi1/2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="233"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="712"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="944" mass="101025" checksum="BE97FDEB3DE503E9" modified="2018-07-18" version="1">MASRAANDGAVRPDVGDLLMVIHDFIARSSDELSLKKGDRVELLERDDEFGDGWFLGRHLTNNNTGLFPEVYTRPTPRAVSNPASTPAFMSSQPLSPLVEVTQEASLQATPIAHPSESSSAMPLSSIASPSALSAHLMKTESAPVSGLGGTGSPVSALDNSGQDEFLSETLNVINEHITHLQSPPGTSAGNTAATDSGSEYSVAIDHRMSYIQGEETDEEEEAEHSRAEVEAWSPDDVAEYLFTEGVEKHHCEVFRDQEISGEVLLSMDQSSLFIKDFDLGSVGRRLKTWQKIKALQDMVAGDYEPDSRRATHTRGSDGGSEDAKRTRSRTSTLTGNSISSRPTSVQARRLSLAQSSNKASPAAHITPTNGTQESPSRTHVKRPSAASIRDLNHSRRHSSTEFRLPGSNATVPKLSANANLSVGDGVHKKQPSFDRNWTLGGAVSQTPQRPLSSTGLQEMLGVSEPELQDSAVELDRGYFSGTEVYRKGRNVLRKRDSANDGTQQSYADEQRVRSATALSRHSRYGSVDSFRDGAPSAAQKYYGIQASPHRRNASTNTTDSVRPTPPAKDGPAPAVTNLDTMMNPALTEPSPVAGKGQSLSTDWLSSVTKPVGKATRPAMRAISDKLTFERSKGSGSADLSTNEPPIPSPVRTGSSTASAGQSMELDSHDALKSPVTATAPVNKKGGKKGKKETSAYTQGLLKIPPAVAMKDADYYGWMKKKSSNLMTTWKPRFFVLKGRRLAYYYSEEDDQEKGLIDISFHRVLPADNERLTGLHATLTGAAGGSIMPGGHSPAGDDGVNKGDDSMFIFKLVPPRAGLSKGVSFTKPTVHYFAVPNLKQGRLWMAALMKSTIERDDTQPITTTYQQKTISLAKAKQMRHRPPGFEDAGAAAAAAAAGGLGGDGGEADSGVSGVDKQLSGLKIDGARLDVNFGDKDSTFSPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C971</accession>
    <name>A0A2T4C971_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C971"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015755609" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12073" checksum="58CC4B435D56274B" modified="2018-07-18" version="1">MCPKLLLLAFRFTGSFTFSVVSSVFQPEGQEALEPKGGEASTFTESRPVYRLMTCGRVRREETIPTRQGTGREEQRRGSEWVPIKQIRYYDETANLPPSIPGCQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9G7</accession>
    <name>A0A2T4C9G7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exocyst, sec10 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_17798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9G7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9G7"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="57"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="193"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="844" mass="94360" checksum="D5898ED905439510" modified="2018-07-18" version="1">MDRSSGPKSIFPKGPNFTLEDFSNKDFIVRDFVDSLAESAMPSARRSGPSQSTTFDPKPLIRSFENALSQLAVLGDELQEKESELLSQVRRAEIQHDQTLDTLGRKLDETMESFEALDISLNPNGTNGADGKADSGGNIAVQIGEKLDDLDKKRRRAQDTIFLINCWTELSETGLLSSLEDIRRQGGAENKVRCAVIARQLMRISQQLDPLAWGTRNGNRASIASFATLTNRARNTREILEKFCETLEQDLLQQFNNSYRRQNFNDMRECAKVLYDFNGGASVIAIFVNQHQFFIDRDQLMSDEMAADGEMWEALADPDAEPPGIEPSLQSLIDEVKIVMQEESFIIKRAFPYYETVLIKFIQRVFQQSIQQRLEKVLDKAESVSTLAFLRSLHSSRSYIGSLVEDLKMHGLTEHPEPCSAQIAQALDQQLDELFVPFLVGSVYIDREKKSLEELYGSLLFKFNLFHSRRKKAPSSFMASLAQQGTQLIQSAKDAYLERLESSDLSATQKAMMLRVAGLQDKDDDNEIEVSDEDGILSVANAKRMLKWLAESVQRVLELGSQLDTPKDVNILLNLLLTNMGQVYIETALDAAHYQATVLENSKTEPDMSYLPPIRAGVTISGLMERFISTVLIRLAESNTTVRKSMEAQKKMAIDTIEKKTNAIMKISIDVIVNWVIKSLGTQKKQDFRPKDGELESLQTATCLHICTFLARASQQAMQAVDGHNADKFFSELGQVLHAQLFEHFKRFQVNATGGLMVTQDIAKYVATLRAWPLAKDVETAIEMLTEIGSLFIVGPEALREKVRTLAPGSSSVRGKLSKADFKAFVQKRDDSGSAGIQGILSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9L8</accession>
    <name>A0A2T4C9L8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1420364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9L8"/>
    <dbReference type="STRING" id="983965.A0A2T4C9L8"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057912">
        <property type="entry name" value="OB_CYT4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25522">
        <property type="entry name" value="OB_cyt-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="431"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="944" mass="105335" checksum="C34C31E65A106AC4" modified="2018-07-18" version="1">MPPDMVLYGGVSNHLSRTQSTGSSEMDQLRPVQTGMIDEFEEDLGGDEPETAAVGGSTRQPGDLVELKQIGSRVPLFAIYLGYFGERNHFYASNGRWLTSMGYSPLFTVANFATPEEMAPVLAKMPKNGSPELFEELRRNEKGPSRDDGARLIEKMVEFRTKADAVHQGNLGKLDAVRTFLSNRRQVSYLSLFEIADILLPASLKTKGRFPPFALYAVHSALQQNEIGFRPLSPTSDCHRRDHLFEVFPQSHAHVINKVVAMVRDYTATCGKRLRQPTPDELEDTDLGLFILQARRTVLASRSKRQWTPHGILTPADGIELPQPEWSQPSKDIIAFLEWWASYDLFEPGSKFHGHGALILRALQLYDDAVLDQSTAWTFLQEIGIIPPWEVPSRYKVRFPDVKITRGGGLEREVPKDIEASKRPDIAAGFRRAHTQSTIFCIDAVSTMVIDDGISLERTDNPDEFWIHVHAADPASSIKPNSDLCKFMELIPENIYLPGHFQAMLPSNLGEEDDAKDYASDGLVGQFSLKSGGPALTFSAKVNRAGDLLDTRVEPSTLDRVVYLNPEDVSRFCNEPPPPPVPSYSLTVGTLEGDGEPEVNRPMTAPEDLDASSKEDLLVLYQLAEALRSKRLSKGAWPYFFPRPSVSVKQGVAPDTTETSRFLPSDPYIKAGYEASTGCSVVSNTMVLAGEIAARWCAFRGIPIPYRRDVEFRHGGNGAFEYATKHIYPLLQKGIEPSGSQRQELMRYTGGIEIASQPGPYFILGLNMYAKATSPLRRFSDLLVHWQIHAALAHERKTKRPIDPDRDNLDAILPFTGRQLATTLPLLQVREKMARTISRGILEWILIALVRAWRFEKTAPEKLRFTVGSRWRQGCIGKVDFFDLHAVMDIEGLNQKVLLKDVRVGDQFEVELADVNVHSRRISVKALKYLGSASGETSSMPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA84</accession>
    <name>A0A2T4CA84_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1390147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA84"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="156" mass="16957" checksum="281EED9540F8D4DA" modified="2018-07-18" version="1">MCGIPYLSRLQVPSARSTEQSTEHLECAFCLHSYMYSSRQAGCPLLALTISYDDYSAVPAASVSAWPSFKQQMGQTNNNGPRPLPHSTASTVSVVSQPSSHPASSYEESMTLKAVSRFYRLSLEEYLGVGPWRWQNASTGSADTTGRVCPRAAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAD5</accession>
    <name>A0A2T4CAD5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1329716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAD5"/>
    <dbReference type="STRING" id="983965.A0A2T4CAD5"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="353"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="753" mass="82177" checksum="36569A843E3A09A9" modified="2018-07-18" version="1">MSSPARSGLVAQDPVPMSSSPSLSQQRPFSSSLPRGEVTARLAEPIRSGSPMRSGSPRPGFTRPEGSASGDASSFAQGPGVSALAAALSDSLGQTPPRHGTPSARVGTPPIRPLSPSGNGRSATPTNYGSFDSRGRPGAESTGPYEDPEIIKRHLVQPSEMENPTSEASSETGKGKQTADFGFGTAGLHDDEFSSLRLQGGDVTRGIYKWTEQAEARTKMQRSKSFDHARPEPESETLDISSIKVPGGFRRNHLRRTVISPSGHPEDGYGGADSPGSNRPLFTSSFLEFLSIYGHFAGEELEEDDEVLGPNEYFQSGQDNEEEENEEPMEDSALLGPSKKKRKRKVRGGSGQNSQMNAALLLLKSFVGTGVLFLPRAYLNGGMLFSNLVLLGVALLSYYCFVLLVTTRLKVEGSFGDMGGILYGKWMRAIILASIVLSQIGFVAAYIVFTSENLQAFILAVTNCRTSISIPMLILMQMVVFLPFSLLRDIGKLGFTALIADAFILIGLAYLFYYDVLTLAAEGLADIIMFNQRDWTLFIGTAIFTFEGIGLIIPIQESMKNPEKFPKVMFLVMIIITILFTVMGAISYAAYGSETQTVVLLNLPQDNRMVNVVQLLYSVAILLSTPLQIFPAIRIAETELFTRSGKYNPWIKWQKNIFRFFVVMMCAAIAWGGADNLDKFVALVGNFACIPLVYIYPPLLHYKAVARSRFWRYSDIGLCIFGLIAMAYTTSLTVMSWANSSPKAPGYCDRRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAP7</accession>
    <name>A0A2T4CAP7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1461682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAP7"/>
    <dbReference type="STRING" id="983965.A0A2T4CAP7"/>
    <dbReference type="OrthoDB" id="2587363at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015710743" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="28561" checksum="342E11BEBB53F62D" modified="2018-07-18" version="1">MFAPILLVLLLVLGRMAFAEPTVGAALFGWPPPRPFNYYTERLAPCGSPLGSGERVVLPTKSARVAFFAERDVGLNLAISYSQDPAFQEDFESLKYSIAAGPVDLVSGITCIILGTPIPGAAHGRNATLQLKYLSNYDSPNHYEYRYSCADVTFSDTANSYNGDICMNKTQPIAYDRLPLPFPDPEDERDDREPPPPDRGNWVEAEVERPPFPSWGVALIAIAGSFLCSIIFLLVYKCIIEPHRSRKPVSSNPWVPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB34</accession>
    <name>A0A2T4CB34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1329335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB34"/>
    <dbReference type="STRING" id="983965.A0A2T4CB34"/>
    <dbReference type="OrthoDB" id="3437405at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="594" mass="67878" checksum="856EBD8EC8748342" modified="2018-07-18" version="1">MTNQLANNRIARGNTPSGALDHVLHPDTPQSELESKLWIVDRILEPQTLPHFLESTMFGTLSDGSRSSFTPLSEEIVMLIQQPLSSWAPPPFDASHEIPMQQIAMRIGSHEDADRLVPISKELHAMKSRLWEGIMPLSERRWEELGLDSEDKFHEACQYICAVTNAFHYLNLPPIKSALRETYNLIWGHLKDFEDAVNAKNRLEGQPEVQIAARWHEYIKAHYQFISARSHKWVIDSLDRLRRPVLDELAGIPSAATTEFSSRQWTLTDRLHDLMENGAQADSGIFLPMDGYEGEGLVAQDDAPPRPDAAEPYRKLPISFSANTQARKGDYYLRLKYLSRTEFWLGQERGGMDVPPGLPTGFELLSDVAQTAQCQVRAQELTRRELRGEPVAFERELWVTKAKDYLGTETNFEWGYVAYRLSHEHTDEEWETFKSKFEEDVQDWGRELKGVEEIRRRSKVYWRDARDLGVADGDADALRTQFQSFRESEGFPSGVHMDIVLAADKGVIDSYLQPTPQQKGFVMAIDVDYDPNEIDGERADESPGYKGVVRVLGSLLWDDLGPLVFMQTQHLFELWPLAMKHPLGVYEGPLRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB44</accession>
    <name>A0A2T4CB44_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1399910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB44"/>
    <dbReference type="STRING" id="983965.A0A2T4CB44"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="400"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="599"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB78789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1114" mass="124178" checksum="8D150E92F7A69D71" modified="2018-07-18" version="1">MAKFVPRQRKHKVLARERAKESARHEVQDTNQEILPAAAAADKKKELEEKKARLKEQLKQDGAKMSGKKAKRLEKYIDNKLRKDENRELLAKLAERKIDTSLFASSKALGQGRETKKQALSRALREHRAGVDPTASVEGILFQERPEVDEEGEEEDDAHMSDDASAAAPVAEDEAKTEESKAADEAAKETTKPAVAAGSGLKRPLELDDEGRPKIQKRRKRGGLKTKVSLVATQQPASKESEDEDEWGGFSGDEEDQAEDDKSDKSDESDEDESDDSSSKGSADDDSESEEEESSDEESEEEELDEEQKTQRSSSFKAWAQQQRNEALGYQPVDPTAAVLEIPKPENFVPRAPEQDPLPMELQVTEKTSRKVYSVPVVRTPEIQEARMKLPVVAEEQRLMEAIHNHDIVVICGSTGSGKTTQVPQFLYEAGYGSPDSPTPGMIGVTQPRRVAAVSMSKRVADELGDHSKAVAYQIRFEGNVDEKTAIKFMTDGVLLREVAQDITLRKYSAIVIDEAHERSVNTDILIGMLSRVIRLRAELSQEDPTIKPLKLIIMSATLRIEDMTMNPTLFSTPPPVVEVEGRQHPVTIHFARRTHHDYVEEAFRKICRGHKKLPPGGFLVFLTGRNEILQLSKKLKAAFGGARTADGPKVQISATEAPVEVEDLDFGDVDEHDFDEVDDIDSDDENEEGEDEFKIDEEDEVVPLKMQVLPLYSLLPVKEQLRVFEEPPEGTRQIILATNVAETSLTIPGTRFVFDCGRSKERNYDRLSGVQSYEIGWISKASASQRSGRAGRTGPGHCYRLYSSAVYERDFPEFSDPELLRMPIEGIVLQLKAMNLQNPQQANVRRLFNQVHKNFCFLDDKSDAIKLLQVVGEFAHEPTEDWCERHFVRYKVLKEIQQLRKQITDLLRANIPSFAALQHQDKLDPPSPKQVSALKQMTAAGFLDQVAIRADLAPNPPEQFRKPRRAIDVPYVPLVPLHRPGSGENPCVYIHPSSCLAHVSPQECPEYIVYAFLQRATPSGALDSGKTPKTRMHALTDVTGGQLAGLAKGTPLISYGKPIKEVKAQTLGADGATTRECWVVPYLRAENTAGQGWPLPAQKVKQRKVAGKGWVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBQ3</accession>
    <name>A0A2T4CBQ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1428461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBQ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CBQ3"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="32"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="464" mass="51852" checksum="FA1529C8D47457B9" modified="2018-07-18" version="1">MAKRRVKKRTHMGANNPQPNSAGHASARDPKSMVIRIGAGEVGSSVSQLAADVRKVMEPGTASRLKERRGNRLKDYVVMCGPLGVTHLLLFSRSEGGNTNMRVALAPRGPTLNFRVEKYSLCKDIQKIQRHPKGMGKEFLAAPLLVMNGFSRPGATAKSKVPKHLESLATTVFSSMFPPINPQTTPIKSIRRVLLLNREQSPEDDGTFILNFRHYAITTRRSGVSKPLRRINAAEQFLGTKTSRRSQVPNLGKLEDIADYMIGGEGGDGYVSDATSGSEVDTDAEVEVQDTAARKVLSAKARAAKAENGEEEEVEEAHVEKHVVKLVELGPRMRLRLTKVEEGMCSGKVMWHEYIHKSPAEIKELEKRWEKRMQEKEARRREQKANVEKKKKAKEAQKAAQKGGKGDDKEDESDDEDDYEYYSDMDVDDFDSEGLAGDAEFKVNEQKEEDGEWEDQEEEIGNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBS1</accession>
    <name>A0A2T4CBS1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaps-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_64201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBS1"/>
    <dbReference type="STRING" id="983965.A0A2T4CBS1"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="691" mass="77524" checksum="04A73F35D2375944" modified="2018-07-18" version="1">MVAPAVPELTEDILHESIDARTEQLATLRELGPPDLVHLVKQAVRNPGKQTGVYHHVTGVDASSSASLAAYINTLTYRDHDPNTTTRIVEGVYCCYNAFSRLDMRVHVSIPGTVESYCVDERGEKRKASDDLWLETYLCSVLRAYSYADDGSGDSIRKIVGVRRFNPVTNTETEHRFLNAAEQLFFRGWQLGSDSIVQVPTNVSNHLTTGLLKYLETTGRYTSGINLFEKLRTQSVEVASLLAKVLFMGNEEVAGVKVLYQSLQQTPMDYVMLDTQADFLMKKALKAGTLELKEERLKMALGCADRSTIAAPSEFSTWARLAQVYVAMEDWENALTILNSCPMFTYQDKDSPMMPEPRDVHLPTLPETRLDEIDSEPEARYSEQVDPSLLSLRAASYRGTFKKAYSILTEMTSKIGWDQLLKIRSNVFVMEDEYRTEKQEATQAAQPMRSPSMDGLRGTPDPTTNGDEGSENGEKAAEPAASTLAPNGENGGVEKPSSTVDPDEVKADADNGTNADDHLSKLNTKRLCERWLDSLFMVLYEDLRVYTIWRTQMAQYRAQQIQYKKSAEEWEILGSLAERLQHFDEAAEAYRACLSLRFSPKALAGVLRVFEKTKSTRETVAAVIRLVTWQYRWYSEFSPELLHTIRTLIEDEGAVKVRSIIQATSLPQNVLDLTHHYAALCATFRSSGTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBT8</accession>
    <name>A0A2T4CBT8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBT8"/>
    <dbReference type="STRING" id="983965.A0A2T4CBT8"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="490" mass="56176" checksum="A6CE85C97095D40B" modified="2018-07-18" version="1">MGGSAFAQGQNPLSTPRMPKEVYDATKSRCREILLGLYSCVESPVEGPAKKDYGDIDFLVASPKSDGAKGALAIPTISQALGAERKIVAGGTEPAASLAIPWPEDDKDEKSEEKYDKEEGSIEKDDKDKDTKDTEGKGKHKDDKEEPTKRYIQVDVRVCESEEKLRWMLFKHGHGDFWNVMGSMIRPYGLTVDDTALWLRVPEIEEHNRKRARIFLTSDPAKVMEFLDMRLEGYWDKAFSSMEELYDYITTCRLMYVDPTLTDSEEPKLKSNDRRRMNYRPVFRKWIDEFVPECRRLGKFSEQKFTREQIAEEAFATFGVEEEFNTRRDKFLAEKQKEYIWNTSIKGGVPASKTGDRFDILYRSCLVKALKKIILEDDTSYGIRPLKTLKKADGMYDLERVDDFISKNQESVGKAAIARHHGAYGEHIHKKECQEGQPLRKKFGVRSLWVTTGFGAFHERQRGENLFSNMEITAKQQPSNNMICTLDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBY4</accession>
    <name>A0A2T4CBY4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1436449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBY4"/>
    <dbReference type="STRING" id="983965.A0A2T4CBY4"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="422" mass="46003" checksum="502D768B0EE2BBD8" modified="2018-07-18" version="1">MAPPTVLIIGCGVAGPVLAILLKRKGYHPIVFEKVRELGNAGASLMVMSNGLKVFDLIGVADAIKTESLPLTTLWDAKTSGDVLGQSDLPSTFAETYRQPATGIKRTTLNLLLKEKVLQEGIEVREGWALVDIQEHEDSVTATFSNGNSVTGSFLVGCDGIKSASRGILQKQKGVEEGLPSYTGLTQTAFLSETPAALQGTAAMRNWYGDGVHVIAYPVGPKTTSWALTQRETQEREETWHPFTADEMDAQRDALCKLLDGWDASIAEGVRSAERIIKFGLFDREELRPEEWFSRRCVLVGDAAHPTSPHLGQGANQAMEDCYHLSTMLPNLCSDNQHEDDINKSLDIIGSSLAESVFRPFAEKRQPRTSVLVKGARAVGEMRVAVGSEKGRERDEAVAKSYEADAAAIVAKFENLLREPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCH7</accession>
    <name>A0A2T4CCH7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1326449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCH7"/>
    <dbReference type="STRING" id="983965.A0A2T4CCH7"/>
    <dbReference type="OrthoDB" id="5429993at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="406" mass="45011" checksum="8A2E5B05FC91EDE9" modified="2018-07-18" version="1">MTLATTKEVTARKEKSAVTNKYPPSTTVTRPSIQTRGRSASISMEGKPRELERRSTGLTYTRGSSTNLAGAATVVKPASSTSRSRDPIRRPATPTAQPGMPTTARRAPSSAGTLLSSDQASQLKRPSNSSLQRSSSPGKTLSAKPSASHLTSTSPSKLPANIAASAEVSKLQAELLQLYLLHQEAPIVDAEWRASAKEKLGNRFDRLSEESREVAELESAGLEKRNVLALRRWGSGGRLDEKIQSLESIITNVWSLSDPGGRYARVIQHFETWIDGVSEMEDARSKGVVLVQGDDSLFIEDLDAQWKEEREDLMRLLEEWRQQLGEIDDLSRDDFYTEPPDDDEKSSLEKMLDGSRSLIDDMLAELRIMEVIEHEALAREDEWIEKMNGDDDDIRVSRLGGAWNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCI2</accession>
    <name>A0A2T4CCI2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_233144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCI2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="79" mass="9802" checksum="BF42EAA0183735ED" modified="2018-07-18" version="1">MDRTIALLWAIRFFYSILIYLFFFSFKLFFFSFKLFFSSGFFFFFFFFFFFLFLFIDGFPLVVLLLCEIMHRCRCLAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCR1</accession>
    <name>A0A2T4CCR1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1166977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCR1"/>
    <dbReference type="STRING" id="983965.A0A2T4CCR1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="203"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="203"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="772" mass="84660" checksum="7EAD3D385C8441CA" modified="2018-07-18" version="1">MAQPPRFYASPRPLEVFNDDIFFENEAPMTSHAPMPNPSRPIRRPLSNSSSNVILEPAVSQNSNRFSPFKPKTTAPRAPLKPSHGLNKFNGISMAPPSDKAPVTDSLQKKPQLSNFKTGLQKPPLANHDAFFEKENVHPQIFPAPPAINISVEQYYQEPSGKRGLMEAAPIKDSRVNNKKPKAEEQVLPPHDSFPPITDDGTKPPHSYAQLIGMAILRSSKRRLTLAQIYKWISDNYSFYNPNDAGWQNSIRHNLSLHKNFIKIERPKDDPGKGNYWGIEPGTEFQFLKEKATRKSVPTAENLPVMSTCLEPSRPAPALMPEPCLPPPAPIHHHQQQHHQHQPHATSLPPLPTSQATLSMPLEPSSDATILLSDNAPAEDLADKGADNELPLESSFFSPLPPALNSTPPVPRPERRNGTPPPVSRNPASSATRTHKRKFASMDDSGYISSLESSAMRPNAARSAFFTSEPDRHRIKRGRAEEEIARLRGSSPFSPTKSRSLSSYGLTSSSPFRPSLDNQMPPPLTPVVKKVKPIAQPPPSVSPNTNLRIHRAKVRHMLQSPLRRVANLSNEDMLPWSPAFRLDDSIFTFDTPNASSNLPEFDIFQDLPVDDENVFDSIGAADAGSPIKRSVKRARLDRSVSSSAVGEMSASRKLLTSAPLLKAPDTPSQFLETPSKVFEGLSSPSKIFQGSPIRGNSPSKFVSLMELPGDGDWPSLHLDVGDFASNVGADTSDFTGLDILQGFEKIGSGSQPSKGLKQSGKPALGRSFTTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCV1</accession>
    <name>A0A2T4CCV1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1428750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCV1"/>
    <dbReference type="STRING" id="983965.A0A2T4CCV1"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="1">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="18171" checksum="2A381FFA216AE0A1" modified="2018-07-18" version="1">MASSQLRAVQALTRGVRASSRTFTTSARRLEAQAPAPVTRTSETDVVLETDPNAITQAPNRATIWSRSQKPRALAMTGPRFEQTDFSLQPQPYAAIELVHQVPVKWTHDKIVSCDGGGGPAGHPRIFINTDKPEIATCNYCGNPFANEHHRKHLESLPETSYPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDP9</accession>
    <name>A0A2T4CDP9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emopamil-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1326158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDP9"/>
    <dbReference type="STRING" id="983965.A0A2T4CDP9"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="51"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB79707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="253" mass="28092" checksum="9D126CA4AC069AC3" modified="2018-07-18" version="1">MASPPSSSSSSLPPDLFDKTTLISLASTLAIVLIAYLASRIALPRSSTTATVRFLFIWHLADALCHFILEGSFLYHCFFSAIPVAEARARGILADLVPTPYNFLGREDGAIYGPQSGGQNPFAQLWMVYARADRRWAGADLGVISLELLTVFFDGPLAVYICYLLAKGKPQASIWMIVLATCELYGGFMTFCPEWLTGNINLDGSNFMYLWVYLVFFNMLWVFIPLFAIAYSIGDISNAFAVREALRQARKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE38</accession>
    <name>A0A2T4CE38_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1372167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE38"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="396" mass="43926" checksum="C2B9E5B459A2CBA2" modified="2018-07-18" version="1">MLAAHREQENRVLSRQVPAKQQPKTPGMRYPKTPIGVGRGDENALAGFAAKSTLQGAINLGENQKLISKKPVMTPAGATNNLGLGIGGKGAVRELEKTQSRNVTSQRRKHKQQHRKAEQLASKGLLFKLRDGHDRDQDEPEYAPPNPEPLPYQSDVFPRDALTLKGLEKENLLKGYYEHFYNPVNDAGVSRAEQRLQEETKAALQKAIEHNERDTEEFDWNSADISVDLERATPEESEVPERTTRAKKKPASAEDRPHDPSSTQPLKATRASRSGPFGKSMATARHADDQSCMATRSSRHRTANVAVEHSSPLVLRSRRDSASSQVAWRDSEVDEPAYMNGSPRLKPSNDAASNDLAHLEFPIDSDDEDAEVDLSLLRTPRRDSFEGSVYDLGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE59</accession>
    <name>A0A2T4CE59_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1399123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE59"/>
    <dbReference type="STRING" id="983965.A0A2T4CE59"/>
    <dbReference type="OrthoDB" id="192702at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021276">
        <property type="entry name" value="DUF2855"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11017">
        <property type="entry name" value="DUF2855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="419" mass="45856" checksum="EB6A48FD19B515CB" modified="2018-07-18" version="1">MAPLAPQIQILEKADYTKQHLVTLHDAYPLPQLTAGDIRIRSRIISNTTNNFTYARLGHLLGWWDVWPVAPSLPAPYNDTSKYGRISAWGYCEVIESQNDRVPVGTKLYGYLPIGDYPETLQVAVDDETGHVLEVSERRAKQMTIYNRYLPYPPETDLMADKHSRGLDSVLLPFFETSHLLNRYAFAWDSVNRTHPLGLPLVWSSEDADLANSVVVMLGASGKTALSFAHQLRHSRPLEQQPRKLVAVGSAASRSFTEGTGLFDDVMLYADASSATDASIAARLGIDANTKVLLANFAGRGTVDEELHAIFTRVSKGVTALIVGGDPQGAASKLGALAEVPGSGVALCNASGLRDSAMELAGTTAYFEHLQQTWNQFKERGAVKGFKLRWGKGVEEYTQGWDLLCQGSIDATLGLVYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEI6</accession>
    <name>A0A2T4CEI6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-galacturonic acid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1397244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEI6"/>
    <dbReference type="STRING" id="983965.A0A2T4CEI6"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102098">
        <property type="term" value="F:D-galacturonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019698">
        <property type="term" value="P:D-galacturonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19121">
        <property type="entry name" value="AKR_AKR3D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044495">
        <property type="entry name" value="AKR3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="309" mass="33980" checksum="B35B8B67338F6D17" modified="2018-07-18" version="1">MVATSFRLNNGLEIPAVGLGTWQSKAGEVKAAVSYALQNGYKLIDGAYCYGNEDEVGEGLKEAFAAGVKREDIFVVTKIWATYNTRVVLGLDKSLRSLGLDYVDLLLVHWPVLLNPEGNHDKFPTLPDGKRDVIWDYNHVDGWKQMEAVLATGKTKAIGVSNYSKKYLEQLLPHATVVPAVNQIENHPSLPQQEIVDFCKEKGIHIMAYSPLGSTGSPLMSADPVVKIAEKKGISPATVLLSYHVNRGSTVLAKSVTPARIKANLEIVDLDEEDMKLLNDYSNDLASKGELKRYVYPPFGIDFGFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEJ6</accession>
    <name>A0A2T4CEJ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1397250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEJ6"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="26499" checksum="4289958C731F5B74" modified="2018-07-18" version="1">MAPVRGRAACDGCRSRKQKCDEKRPTCSRCRDMKRECVWPKLYKRGPAKGYIEALEHRLAVTEAVLLQLLQVSDDSLLQDAFRHEPAKRADVLSTAAMATTTTTDAAGRIEAKKTGTIAHWDSFPLTTADEVKRWAGEVLGRCADTLQPRENTPEDPDQTAFETYPVPPAPLSRSRPEKRSRSRSSVEAYQPLPMEPTATALPTAMEPASASDAAFSRDLATGQVFDLSQDFRRQYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF44</accession>
    <name>A0A2T4CF44_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1397511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF44"/>
    <dbReference type="STRING" id="983965.A0A2T4CF44"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="6">
        <location>
            <begin position="45"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="29014" checksum="65EFF3EFFF2D9515" modified="2018-07-18" version="1">MMRVTQPMLAKGFLARSFDELKRRSSIAWNLDAVKGPSGPRELYNFHSAESVSNCIVMADTLIGGSSTSHFDFVPATASSPTQTPASSAHARFYGHISTSLPPDRLAIQRTGYAAFRTPDQPPTAFGRSVWDIDPYTYLALRVKSDGRAYYVNVQTESVEPTDLHQHRLFAKRPGQWETVLIRWNDFVRTNHGFVVEPQTELLRQKVHSVGIGLTDRVEGPFELCIERVWATNGADEKAAAHEGQQGELKNRKGENIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF46</accession>
    <name>A0A2T4CF46_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1323902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF46"/>
    <dbReference type="STRING" id="983965.A0A2T4CF46"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000733">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="509" mass="57791" checksum="AC63821606E84A09" modified="2018-07-18" version="1">MTLFRGTGLAHQAADPKDPNRFPKVPSDEGRKLMGSGAFGVSETDLRAKKTIARRLLERELGLGDRVWRKRNNGILAQNLIPGTKAEKIIHYDHPIYSGQFSDDGNFFFSCCQDFKVRMYDTSNPYNWKLYKTVSYPFGQWTLTDASLSPDNRWLAYTSIQSIVSIAPTDPRDKGEPYSLELDDGDGHARLSFWRNRGSFGIWSVRFSGDGRELVAGTSAHSLVVYDIESRTVLHHITGHQDDVNAVCFADKSSPHILYSGSDDTTIKVWDRRSMGDNREAGAFVGHIEGLTYIDSKGDGRYILSNGKDQSMKLWDLRMAMSTDRFREVTRDNDSRLDRFDYRQDEYDEDDWDVHPHDNSLVTFRGHKVLRTLIRCHFSPPSSTNARYVYSGSADGKVHIWNMDATKAGEIDVRRATHRTRKLDRRTRVYFDEPGGWGTCVRDASWHPSAPVIVASAWNGYSMARGTCSVHAFNESLEDEGEPEMGDSVDESLRPDPETFYRSSFQSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFC1</accession>
    <name>A0A2T4CFC1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_46405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFC1"/>
    <dbReference type="STRING" id="983965.A0A2T4CFC1"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="378" mass="41876" checksum="0F21FD6BA250234C" modified="2018-07-18" version="1" fragment="single">PPVTPSELEHLRMVIKGNPNDQASALKLAKRLIEASDVLIPNVPDARARSKARERYLADAHKILKKLVHSQNSDAMFIMADGAGRGLFGPEADSKEAFTLYQSAAKLGHAAAAYRTAVCCEIGHEEGGGTRKDPMKAIQWYKRAATLGDPPAMYKVGMILLKGLLGQPKNPREAVGWLKRAAERADAENPHALHELGLLYESAQGNDVIIRDEQYALSLFQQAAEIGYKFSQFRLGCAYEYGLLGCPIDPRLSIVWYSRAAQQEEHQSELALSGWYLTGSEGVLGQSDTEAYLWARKAAVAGLAKAEYAMGYFTEVGIGVPANLEDAKRWYWRAAAQDFPQARERLEDLKRSGKEKARPRERISRSRIEKQDGDCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFH2</accession>
    <name>A0A2T4CFH2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1122155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFH2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18081" checksum="8E021B57413315F9" modified="2018-07-18" version="1">MARSPQPTYAFPALFLQNWMTRQLTAQGSSPETCAHHPSTRIADMSKTAASTEWLFPAMSICYLAGVSGAGERIIMPPCARILHAALWPWAKSAAHVTLGRDSLWGATVRHANTLVVCFILCRPDWLRLTKDAGAMDPNQSSEVGGYIVGVMSVDIRSALLWVPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGT8</accession>
    <name>A0A2T4CGT8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uridine/cytidine kinase</fullName>
            <ecNumber evidence="4">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1451030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="4"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGT8"/>
    <dbReference type="STRING" id="983965.A0A2T4CGT8"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="252"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="447" mass="50461" checksum="F1538E943179CF4F" modified="2018-07-18" version="1">MSQLESHVTVQKRAYYSPPWADVSIIAIAGSSGSGKSTLSQTIVKKLNLPWVDSFYKTLTPAQSKLAFANEYDFDSPDAIDFDALISSLRDLKAGKRAEIPVYSFAHHARLERTTSIYSPHVLVLEGIFALYDPRVRELCDMGIYCEADADTCLSRRIVRDVRERGRDVEGCIKQWFAFVKPNFEKYVEPQRKVADIIVPRGIENRVALDMVTQFIEKKLFEKSTHHREALARLEKKGKEEPLSDRVVVMSEGPQIKFMNTILQDIDTSAEDFIFYFDRLAALIIEQALNNVHFEEATIETPPGYKYNGLRPKGEVSAVIVLRGGSAFEPALRKTIPDCRTGRLLIQSSYSTGEPELHYLRLPEDIHEHESVLLLDTQMASGGAALMAVQVLVDHGVALERIVLATYSAGKVGLHRLMTVFPEITAVVCNLLPHAEQRWVEQRYFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHN3</accession>
    <name>A0A2T4CHN3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1006722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHN3"/>
    <dbReference type="STRING" id="983965.A0A2T4CHN3"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="17910" checksum="5E21C4372A60DA2D" modified="2018-07-18" version="1">MKRRVAEMEEEAKKLREMQATLEQQSADLADDKESVDARSIFVGNVDYSASPEEVQAHFQSCGSINRVTILLDKFTGQPKGYAYVEFTEPSLVAQALVLNESVFKGRNIKVTPKRTNIPGMSRGRGRGGFRGGGRGFHGRGGFPRGGGYRGGYRGRGRGYAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHW8</accession>
    <name>A0A2T4CHW8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1427125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CHW8"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="12">
        <location>
            <begin position="1526"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="893"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1808" mass="199246" checksum="8E391344D80C232D" modified="2018-07-18" version="1">MATSLAQQLAQVAANSKSSLDIKAQRAAHSKSLIWEPRVAAAQSFQTLYATCHQGFEELCQLDARFNPFQQTLFSEQSQDQDRNQLTIAENEELDRHIEAFLRLVGSRLRLMPAIKAVEWLIRRFNVHVENTSILLMTFLPYHSITAFATLLSILPPKIPSQFRFLDPYIRSLTPPPRSVIVHQAIHHVDFLVSASEYTLESCRKGYQYPALITFWGGLITESVSGILDRTKSGRAAVQSDNSQALLHRLGPIFAESLVMKKVPSLQIASYMAMTVFVSKGDLHDNAVTALMQQLVHGWTADTVRAGLVCLTILAQFRSAKQMSSKVTRALMKVQDIGSLLVEIGRERRVDKLANGLCLALVERLVKKGDSRGLATITTILGGNVLKDKQVSVIFKSLLLTAHELNDENDEDGSLRRDVGSTLISLSQTTGSAGAIIQSVIEEVKFDIEELEMKLDLVFRTRKLPEYAREDEGGDAAVQAQPSQDPEASLAELANTSESLSSSLSPDGDSLFSKLSDVFVSIVSDQTPRKTELLGQFDQFPKLKRELALEDCTYFSFFIRIWCGLYPALARTAALDMVKNKLKAATDSVVDIQALIPYCVAALGDPSKRVRQAAADLITVAAGFYKPPFAKKSTNAWGAESLYGKAKSKEVAALGVDVACRFLQLQLLPAIEECVMDPEHISAVLKSAIETGKYQVAPEPSLDKKDHLSHSGRQALLTFFASHIVATPLMLVKSRLLKSLNDIRGVSNVTRTQLLLPALQWWASLTDAEATEICASQQLDKAVLDAQFIDIIVPNDPAGLEFVFTLLKDKTNDARPGLIRAVFSRIKKMWPAMKDEMKFMVAEQFLELSQEAETPSSGATESIIPAEAADLLRSVTLTTDILSYFLDSIQTGTKMITEPPPNKRRRTSSSDASRGLHTQVTPELSRALRKVTFVLQIVDSSDPVSHPELLDGLFTALSELQHFRTVVGSELGYLQNLILRSLLAMMPAYKANKDLKVDSSGGYGDLLVNCIQKSSSPVVQNAALLLIANLATIAPHLVLHSVMPIFTFMGTSVLRQNDDYSAHVVAQTIKEVVPPLIDSLRQGQKSPVAGASDILVSFTTAYEHIPVHRRHGLFLALVETMGPKDFLFTLVAMLVDRYELSDDLLQFVLELLNAFSIEIQLETLVKLLDLTSDLFKPKPGLSLVLLGSGDESEEKDVEQVALRQLSVLPSLLANRKLKAQISKLDDRDDMETSEIRRLYATLLEDVLVLADTVKANKSLHSRCGNALANLLNLLSIGEFIKAVESLLDRPNLDLRQKVLRALELRVGSESNTDVASRTALLTFLPQLTAAIRESSDIRYKHTAVTCVDKIAEKYGKKDIEAVVAAASTIAGEHCLGQDEKQLRVMALLCLTSLVDVLQDAIVPVLPVALPRAVAYLNLSLQQDTRDEELHAAGYGFISALAEHLPYMLSTYLGQILEVSNKSAEAGLDAETNETRVSCLEFLAKKLEAKEIFTSLDSNWESATSSGFSATSEYIDMLGMAIDKHPKSAITKNAGVLSSILLKAFDLRRQIIARGEASDAVLARVASLEASMNDKALKMIYKLNDAAFRPIFVQIIEWSSAGLSKDKAGLAARRYSVYGFLQTFFDSLKSIVTNYATYVLEDAVKVLGTVDPKVGGEKQLWSRVLKTLAKCFEHDQDDFWQAPSHFGAIAPVLMEQFNHAVSVDVEEALIPTTVEFAAAADSQAHQKELNSALLKHLRSEKAAIRLAAVKCEQALTDRLGEEWLSMLHEMLPRISELQEDDDEVVERETHRWIVKIEGVLGESLDAMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI59</accession>
    <name>A0A2T4CI59_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1345891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI59"/>
    <dbReference type="STRING" id="983965.A0A2T4CI59"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="367" mass="39007" checksum="EE294B2B47BA0D9B" modified="2018-07-18" version="1">MSLLRSSLCRACRRSSPLLVRRGFATAGRTQASSDNRVKIVEVGPRDGLQNEKKAIPLATKIELIERLAKTGLTTIEAGSFVAPKWVPQMANSSEIMEHILQQPIDAPVPVTYSFLAPNTKGLQNAAALLKQNPGRFSTQLEPDEKKPGIEVAVFAAATESFSQKNLNCDIKTSLERFRAVIQESKALGLRVRAYISVVLGCPFEGFDVDPHKVAEIATDLLESGADEISLGDTTGMGTAPRTSALLRCMSAAGIRNEDVAMHFHDTYGQALVNTAVSLEHGIRIFDSSVGGLGGCPYSPGATGNVATENMVYFMETLGMETGVDLDGVADIGAWITQELGKANDSSVGKAVLGARARKSAEAAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI71</accession>
    <name>A0A2T4CI71_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1396401</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI71"/>
    <dbReference type="STRING" id="983965.A0A2T4CI71"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB81250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="449" mass="50137" checksum="51D7A06E671AAFFE" modified="2018-07-18" version="1">MREVISINVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAQDPDQGFSTFFSETGQGKYVPRAIYCDLEPNVVDEVRTGPYRNLFHPEMMITGKEDASNNYARGHYTVGKELIEGVLDKIRRVADNCVGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGLERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISAAKAAHEANSVQEMTMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPNDAHNAVATLKTKRTIQFVDWCPTGFKLGICYQAPENVPNGDLAKVNRAVCMLSNTTAIAEAWSSLSLKFDLMHSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSLDNEEMEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ93</accession>
    <name>A0A2T4CJ93_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1321586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ93"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ93"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59745" checksum="FF20BEE0FEC6C022" modified="2018-07-18" version="1">MLTNWFAQPAGNRSSVDEGKIDNDDDTQVMEPDQGNVLSHIISQLRPGADLSRVVLPTFILEPRSMLERITNFMCHPEMLLHIPTIDDPTERFVSVVKFYLSGWHIRPPGVKKPLNPILGEIFSCYWDLEDNKRAYYISEQTSHHPPKSSYFYMAPHHHIRIDGTLKPRSRFLGNSAASLMEGIAFLSILSRGSNKVKGEQYILTQPNMYARGILFGKMKYELGDHSFVRCPELDLTADIDFKTKGWVGGTYNAIGGVIKRESTGEVLYELSGLWSEEMFIKDMRTGQREMFFDALKAKPSPPLSRPIAEQEERESQRLWEKTAKAVKERNHELATDEKTKIEDRQREEAALRAQENIEWVPRLFRAVRSGPGEPEEGEESLEWIINANMYVWCQSLMLVERTSIKQLTPHSDPTAPPEKQTEQILAIYPIVAGQTLNKETAIPPPASSSKAAHEPVEPAAEKPVEPVVEKPKGEDSLIDFGNDETATPAVKSPDEIERMLAATGKPADGPLIDFAQDMKKDLPADGGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ95</accession>
    <name>A0A2T4CJ95_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1019507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ95"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ95"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="225" mass="24498" checksum="741C8631A2BEAEB9" modified="2018-07-18" version="1">MEAEERRNRRRREERVAIPLAQFGSMARLGSSSSRLASGSGSLSRQPSGSDAVEEDEASPQMGYFPPHSSSRRPKSGSSTSRPSSIHEDSSKDPFQYLSAGPRGSTSSASKRHSSDLSSLSRRGRPESAEWSRRDSSRRQSSDETSEELALVEEKSSRAAKGREEIVVEVEPESPVGPEPASSRTRSASRRKPESVSSRRTVSSRTTTGSGASSGVRRKKRDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK20</accession>
    <name>A0A2T4CK20_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1347192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK20"/>
    <dbReference type="STRING" id="983965.A0A2T4CK20"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF8">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="553" mass="62167" checksum="352DEE7F7E19894D" modified="2018-07-18" version="1">MAFDPVGDAFAPVAGHNTATPVSVYLLTLVALTVAFLFAYSRLQKNKREVEVDFPPWVPLEVGISSALIQAGGTASWLFSLIWPRKGSRFGLTSRHQILHNLDNIDRVFTKSPHILSADVLGLRLGIRVFGARLTKEISEEFLVINRKLTQIIERYFVNDASATASIQSADIPGKVARLLSFSPDAQKQYQWEQSAAIKVLSTNSEGQSGAVEADLESLMRDFGACVSIPRLYGQDFLDRNPHLLEDFWKFDNNAFSLLVIGVPTWAPIKSFREALAARTRLHDALEGFYIRLDQYKHGRKVDFDADMRDVSTAAMERNSFLEEHGVPIRARAELELGTFWGLNANMQPMVFWLLLYVYSTPGLVDELRKEVSPCMTMSTADCPLHITALDFSRLSHECPLLKSCLFETFRLVEDPTSLRYVSKPMTVSDGELEHHFKPGTWLSAPHALLQSDPSIFPEPEKFIPDRFIETDKETGHRVARYGRLKPWGSGSALCKGRTFAEKEVMGIVACFITLWDMENAEGPWKLPSMIPGTGVKRPQKPIRVVIKHRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK29</accession>
    <name>A0A2T4CK29_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1322157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK29"/>
    <dbReference type="STRING" id="983965.A0A2T4CK29"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB81929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="224" mass="25248" checksum="8F1E5932782ACD81" modified="2018-07-18" version="1">MAQREEPCRILVMASGNGSNFQALIDAIASEAIPNSRITRLIVNRAKAYATTRAEKAGIPWEYFNMISNGFLAKGEKDEAKTAEARKRYDAALAEKILKLEERPELIVLAGWMWVFSSEFLRPLEEVGIKVINLHPALPGQFDGAHAIERAYEDLKAGKIKYTGIMVHYVIQEVDRGDPIMIQEIEWEGEDLEALEAKIHEHEHELIVKATAKVVREVVAGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP36</accession>
    <name>A0A2T4BP36_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1345047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BP36"/>
    <dbReference type="OrthoDB" id="5215300at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="358"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="598"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1399" mass="160141" checksum="5CAF17E307000DC0" modified="2018-07-18" version="1">MAPGPTASAHPPVAVSRARSPTILIELDIAVLHAIITAAQEHLDNAPGPKPLPAAALFKAYDEILPQHGIDPESDHHLSALVFRVGGEQGPGSLLDKFQSILGRIGIVLEFSDDSTTSPEGYPEHPLSPEPLDTHRWYPDDLPIDEDEDAPPKRPRAYSATSLGTDTAPQKIQSQEPSTKKEYQSRDDHAPAPTDGNAYSSAQISSTATRHGDPYHHYPSPLFDHLPLDLDHPDDNPKARRLIPQTDISLRSAERKSEHDAQTVDQPLGRVKDRDEIRFSDVEDDEKLAHDAAKQEKRHPKKTIENNKHNDRTEDEDMAQPPHYLPKGVQTAAQSERDEPPVSVPSENEHTFSRWHQERLLTRATRAREIYLASKVFNHWADRTAGRLEREGVARRHMIRFRCFQGWSCAPSLRYPIVENLKALTAVQKLHRAVSYQQEQLSLAASVIAQRHRARVASRVCDQWCSHLVALAYRRKLDKKLKQRALLAWKVSTSSNFVKSQAISRFNRREGIINALSKLQDHTIINNRQLHAARQLGSLQLLFGCLAEWRDQVQVRAQSSAYRDRLAIATVSRTLENWKLSSRVQAVRWRADFISVTRALEGWRGQYMQEEWRRSLCANHLKSYRASNLLGALQRSSSIEAQRSHLSHRARLFIITTRVLPIMDSAVQARKSQMKEMIREYLMMRYTQVSSVRKRRKFYEALDHWRAMTSQAISESDVVTMYNAKYYYGQAELALTKWRARTEEDLEAQLAAYKHYAQSVLATWGDVAKERERMEMQSMEIWAARRQRQYLKAWSIWSLQRSGQAHTATKVLVDRHNKQDVAGVQLETPTRWTGRPLNMSLPLSAKPLASWRETDEESATSSDTDEVGMQKSPSKPPSYTGRVTLSSTTPRGPVPLRLNLNTMRAGTSPQRWSKSDSPLKSQPGQAQDTSRVPQSTPQPIPKPNFGSSLQRIRSMWQFANLCQWIYIFGDAASIDNAVDVDYIETECLKPNSPGLNDIALALLRLVSSQRGLTHASFDDQARKQYLLRSPDTNPFGDDDAPKSFAELDVFSKIRVMQQFTQWAMIRPELLREKMKEQKDTEQTTWRIEPYGWDSEDRTYYVLDDNRVYRMTEAPPSHKPAPSKTSRQSRRTGKRRRVSEPDDAANETLDENPKDGSELHYEDTHLGDMSWECVAVTLPEVQALVESMAKSRDENEKILRKQLRDHLVPILEKQEQDRIRRELRREKELATLALMANAKRSNRIASKAEQREQQEKARMEQERLREEAAIKRREEQKRVKIQREMEMRLASREQRLKQREERRVRRGESGTPASVGEDSEVTVADAIPGQSRSENGENGRDPQAKQEEEEEPWQVPWDQRGCCRPPGFPFRLCLLSSKEPAWHGNEEQKPCCAEEPCRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPB9</accession>
    <name>A0A2T4BPB9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1366244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPB9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPB9"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015613295" description="Cupredoxin" evidence="2">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="21953" checksum="702AAF3D2034CA22" modified="2018-07-18" version="1">MHATALASAAIVALASHATAETIKIDVGPNGQFAFQPNNVKAKVGDVLSFTFHPLNHSVVMGDFANPCAPAKTGGFFSGFMPVSSGVGSQTFDVTVNSTDPIFFYCAQNKFSHCISGMSGVVNGPSSGNTLDAYQTAAKSVKSASNPDHVFGGTLVSNADSPSPSTTSAAAASTTSCTTSNKAPNGNGYKRDTCSGAGTVQTSVGIVAASLCMALLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPD1</accession>
    <name>A0A2T4BPD1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1366257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPD1"/>
    <dbReference type="STRING" id="983965.A0A2T4BPD1"/>
    <dbReference type="OrthoDB" id="5415867at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015637021" description="Cupredoxin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="19985" checksum="7090486BCFCE3BDB" modified="2018-07-18" version="1">MVSFNVFTILAAAVASVSALPAGTATIGNRLPSRTFLTGVTHSVVAGRGGNLVYDPDNVVAQPGDTVEIHFLAANHSIAQSDFAHPCTPLADGTGLFAGFNFATSEGQNPNVYQFTVIDNSPLWFYCPQPKGAHCTKGMLLAVNQNFDSQNTLSKQREIAATVEPVVPPVIQGGRLGGFQRANPNPLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPF9</accession>
    <name>A0A2T4BPF9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1365991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPF9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPF9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB71181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="332" mass="36248" checksum="8762E5DECF35A597" modified="2018-07-18" version="1">MSKYLRQYWPGAPTKTEKDLPDLHGRVFIVTGGTGGIGLAVATALFHANASRIYLLGRSDSAGKDAINAISKSDPPSDMKRRTADGNGVVKFLYLDLSDLQTVKPAAEAFLAGETRLDVIWHNAGVMAPPEGSVSKQGHELSFATNVLGPFLLQHFLTPLLLRTATETAATKGSVRTCWAASVEFPDPPGEDGILWDDWELKAPQFSGLNGRVQRYVQSKWANAILATEMAKRYPQLVSVSFDPGAIKTDLTRHAPGILKKVQGFLSYPVRFGALTELQAGFGSEVAEHNGCYLIPWGKIGKMIPKVAEGIEKRRSGERLWDMCDGLVKEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ89</accession>
    <name>A0A2T4BQ89_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_214312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ89"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="141" mass="16257" checksum="3BA074F6D894FA35" modified="2018-07-18" version="1">MTWRRQALTSQVGFHDSLPARNPWPPICSLWSFSGFFLWHYRSSTPRGPSHLLPSLPLCPSRALSLSLFCPTYFMGWLWLSLRVAQNPSPKLCRPVHLSSTSNGHPAAVSTSLRPRYSRCNRWLLQEEEKVHIGRREQQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQG1</accession>
    <name>A0A2T4BQG1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1473376</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQG1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQG1"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000082">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="247"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB71552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="321" mass="33921" checksum="3AEFECA2D367AF8C" modified="2018-07-18" version="1">MELVNSLEGRLLFAVPKKGRLNQATLNLLEGADIQFRRENRLDIALVKNLPIALIFLPAADIPTFVGQGRVDLGITGWDQVKEHDAAVNAVAAHGGAPAQGSGCEMITELGFGACKLQVQVPEKGKYASSADLIGRTVGTSFVNLTADFFAQLEAQANGAAANDSSPPQKLQTKIVELSGSVEAACALGVADGIVDLVESGETMRAAGLKAIDTVVESTAVLIKSRSPSNPDLVDLIASRIRGVITAQKYVLCQYNIERSGVAAATQITPGKRAPTITSLDDGWVAVSSMVEKKKIALVMDELTRVGAHDILVLDIHNTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR61</accession>
    <name>A0A2T4BR61_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1442311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR61"/>
    <dbReference type="STRING" id="983965.A0A2T4BR61"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="827" mass="93872" checksum="0AA339180C00B563" modified="2018-07-18" version="1">MDMSFGADPSAADGFYSDPANFFRALGRPTPKMPSAAEIRDKARKRAAATFANYELLNQILLRHEPTIRKRWTKKGRQQRLKVLLKAWPQMAPNHRPDYEAFRKAKSQPLQHASKQVKDSFMWPYINQEDLAQTQPLLLLLNARGRYLPSSFAAADIEAMHLGIVTEAIERIFLNEHTMILHGVTLAKEYGKLVAWDDHPDAFDWMHTQKQFNPGDGLIILQAQDRLMKFLVDCCHEILHDIAHDQLLSEAYPIQPEPPLQTGDEARGFESLASMAAKAPYRVPAQLDLGRVESLLSAKARAAEDHLWALREDPAYFRQYVLDAREHRLEMIKDALNNTHPTMAPGREGLFRARVVGEVVLEAYLELEFYSELHRQAQNLVALKKKYEAAISPLEDLPEEYLNALLTFRHFLNQAVKGPLNQLKTAGPACPPMRRFFVRRPPEDASSSKMAISASGLKKTNVEAQLLYLLQTLWENGNNLFLLRLSRVVDELERLLLTEPTAGDLISNYVARLVGNLSIISQCIHQLEIYQPWAQNFEDAFLRVEAEIQQEFATRSEPWGQMMAALSDTKLAGAARLAEPLMRSFAYPIDKRRTKENVEKLRQAERDLDMFWAEVDLVMRPASSKLKDTAVQKLFTQASLQRTPEWVDQPTPLNAAATAHMEQPLSPLYFDLWNGRAEAQTKHGGVHTTPAKAKVKTRGKADRQTEPSHSVEPTHHEEVETSKPCISVDSRAFKVFRTLFFNSDITSTPGEVPWNDFVHALTSVGFAAQKLYGSVWQFSPSGLDVEASIQFHEPHPRGKIPFITARRHGRRLARNYGWAGDMFVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRC0</accession>
    <name>A0A2T4BRC0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1426165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRC0"/>
    <dbReference type="STRING" id="983965.A0A2T4BRC0"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="424" mass="46872" checksum="1B06EC90C4740F4C" modified="2018-07-18" version="1">MADVRALLRQQRAARRITHPHATYSDTGKLLCTLCREQIRAESHWDAHLASDKHRKRLSATISTPTNVNGKDDYRGSEEGNDQEQSEGLDDAQGREQRAETPSSTHKRKLDHAAATAADGEHEDTDKDVDDEDEVRRKRSRHASPETGRRKPQGPSQGVQVQMPSRSTTPADSQHSGSSAAKTTTTTTAKLATSLPSRQASNLATPASSSSMSIQQEAPPSQQQQQQQEPQPLRQPPASTTQDQKQIDEDEWAAFEADIAAETAPYDADAVISRPAMTAEEAAAAAAREAEQEAALQNPESRRTRADADIEDEREEATRALEEEFEEMQELEARVQRLKEKREALMMRRRGETVVGQDQAEDDVASLQASTTKPSSDTQGEGKENAISTSDTNGPKAENNDEDDEEEDDDEEDDWDGFRFRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRE9</accession>
    <name>A0A2T4BRE9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1395358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRE9"/>
    <dbReference type="STRING" id="983965.A0A2T4BRE9"/>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="326" mass="35487" checksum="C026D1B83A0D05E4" modified="2018-07-18" version="1">MSGSGAPGGLPLDATVTIVNNSGKIISTGKQLLSIWKTAQASYREKKTELNQERAAERSRPPPVPVKRAQTFDTSRGIGAPPRRQYDELSIASSHRTFKSSIAKKQLPPVPNQLALTEGNLEKLSEVSSAVAYEGAVAAPAAAVPRLEEPVDEAIVLETVEVDISGIDTWRRGIVDWGYESADQELMTPEADRVTRERRASKGGPPEDYFDSKSRRSSKTAHRSSKGHSSSSSSSHKSHKSRHESSSSSDKKSSSSSSSKKDREKGDDASSINSMSLIKKSIASRKKAIDESGVKSEELPLRAKMRQTNMLKALFKSKEHRQTLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRS1</accession>
    <name>A0A2T4BRS1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Woronin body major protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1343062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-5A family. Hex1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRS1"/>
    <dbReference type="STRING" id="983965.A0A2T4BRS1"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140266">
        <property type="term" value="C:Woronin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04469">
        <property type="entry name" value="S1_Hex1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000033">
        <property type="entry name" value="Woronin body major protein HEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037318">
        <property type="entry name" value="Hex1_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A-like N-terminal" evidence="5">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="4">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="223" mass="25026" checksum="3FBF9114D658FE8B" modified="2018-07-18" version="1">MGYYDDEGSYHSLKHGVAKAVDKLLPHHHHHHHHHSDHHSDHHDHNNTTITEHVEVDVVRHDANHSRRAAPATESQPQTVSIPCHHIRLGDFLMLQGRPCQVIRISTSSATGQYRYLGVDLFTKQLHEESSFISNPAPSVVVQTMLGPVFKQYRVLDMADGYVTAMTETGDVKQGLKVIDQSNLWSRLQQAFESGRGSVRVLVLNDGGHELAVEMKVVHGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRV7</accession>
    <name>A0A2T4BRV7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_68581</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRV7"/>
    <dbReference type="STRING" id="983965.A0A2T4BRV7"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="370" mass="42015" checksum="8EBD30F392C7BECB" modified="2018-07-18" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQAIAQAAGQANPEDEEKARASRMNAAGPVTAAKAGAVPSSRRKMLERGSGAGVDTPDTSRAIGGSDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS02</accession>
    <name>A0A2T4BS02_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1395101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS02"/>
    <dbReference type="STRING" id="983965.A0A2T4BS02"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="240" mass="26111" checksum="5D68F605F6C0E3B8" modified="2018-07-18" version="1">MEDYRYDHDHDHEYDDDDTMSHADAADTSSHHGHDDDVFSDNNSPRSSMGSVSEGDPRKAAHDGLRSPRISDIQQQYDEPRPSLRSASSSAGKAAQHAAASSPAGQPQPRSGRRSALPTDGDVSFSPTSAVVEILLTPQAKADGENPCAAMEPQTVEKWLTATVTERTTVTRTDMPDADDDLFGSKEGDEEVDDESFEGAKDADGVHYLDGLPGDEEAGEQQQTSGQSDWEWGARFKFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSD9</accession>
    <name>A0A2T4BSD9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1449201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSD9"/>
    <dbReference type="STRING" id="983965.A0A2T4BSD9"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="471" mass="52537" checksum="B7DF4186608F8C4C" modified="2018-07-18" version="1" fragment="single">ITCRHRKLKCDEEQPICHNCIKSSRDCRYIERAVFRTFDSGVRLKRRTKNKVNRCEPFDDDQIWLDIPKDCKRFVTQVLLLKLTPYSSKVCEFDSTSAFQCEPQAPGQGAARVVDDEITSSPQGRKGRNVEASESDEGVVSQGFLATSHDDEPLPMPRLDSSINDNLLSLRLLRHFKEGPGQWMDTFDTGAYFSRKVTVMASTKPLLKSAVCALAAKHLGHCQNIANGQFREKQEGGRRAIATTEHNVDWQYQSTKHYDSAIKHLKIAINRGAFETDDADKEELFASITILCTYELMDAPGTAWSAHLSALPLFSPGFDSESVLGSPIAIPRAAVSGPIFWSLARQDLLCSFISETQTRLDLEDVRLWQDAGLVTDERGSVMPFYISNAADVEEDAKSDELVWLLGKIANHIAAGDALDPKHYALPPGKRPRGSSPCSRDLWHWPGESSRFRTSALRSGSFCSGPSIHRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSE9</accession>
    <name>A0A2T4BSE9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1433827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSE9"/>
    <dbReference type="STRING" id="983965.A0A2T4BSE9"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015655967" evidence="8">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="260" mass="29093" checksum="9B429CE03A66B7B7" modified="2018-07-18" version="1">MLLFGSILPFTALATAACAAKFPRPHIQPWVPPGPNDSRGPCPMINTLANHGYIPRHGRNITASLIEHAFTSFLNVEAGFADPARDFAKVFGHDVFDLVDLNTPGIIQHITSLTRDDYTPEEPHLLPDPVRIERLLADSDTPFLTVDSIAKTRLRLLQESEPRVLPDTEVTFTLFEAAMTLTMMSDNSPDADTKPPASTYKAPKDRIRMWFEQEKFPTEFGWRPSKRTIRLADMSPAIDAIVKSMKKQDQNGKVAIKFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT87</accession>
    <name>A0A2T4BT87_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1425641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT87"/>
    <dbReference type="STRING" id="983965.A0A2T4BT87"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="34"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1181" mass="129766" checksum="EA49524C080545D3" modified="2018-07-18" version="1">MASPGIAADPQDGPYVLQPWVDSVPLSADGSQDGIKINCVEYFDGNLYVGTSAAELLHFVSIPPDPSDKSGRPVFIPASRLSPAFAENTTSRPGVQQILLLPRVGKACILCNGTVTFYSLPELSPVFGSKQVKNCNWIGGVDLNEEGQGDVVANTGETVTVLLSLNRRIQVVRIDEDVRAVKNIEFAGTTLSVRRDSIACVADSKTYALIDVNRQLKIPLMNISSLDENPTASAEFGHVLNIAKDPNVGRSASSNQTRPPSSSQTHGRSASLGTAATTADSLKPDAQGTSPRLPISQTHSPPGQPSSPQPPEHSSTPPPAADKPLPAPPPSSSPAPRPAAALLKPHITSPTPEEFLLVMGTTPADPGVGMFINLDGDPTRPTLTFDIYPEQVVIDNSSSDDTASTEDEDGYVFASMTKDINGVPHSGVEIQSWNAGSEAHPQKQWLVASDADLEGKYGIRAVASRHETQSEEIVDKLSLKKYTPFPSSTDSAPTTTTLKSSDSRTALSIERLAKERELFERDVDSQDGESLPEGWEAARTVEGEEFARRLSKSRTRIAVWRGNRIWWAVRNPLIVQLDKRLEAASLLQQSEGKEIDKRAIIMALSSIRDREPKTELEFTTFGYVQQKAGVLLLINLLLSSSDGEVSDEELAALQEVLVESKLDPRVVLSLIPGVRNEIIEGRKGIWIHGGVKESPEAFLASPAFLELSQGGIRGLQLKILQFLRRYLQAWRKMKGFGSVSVEAEVFRTVDAALLLVLLELDRHSPKGLGKGGAVRAELGALVDGGMECFDRAVSLLESYHRFFALSRLYQSRKMSADVLATWKRVLEGEEDDAQELVDGEQRVREYLSKLSNQALVQEYGLWLANRNPKLGVQVFADDKGKSPKFEPTRAVELLRAEAPGAVKYYLEHLVFDKGHEAYVNELISYYLDIVIDDLKSPESQETVKAAYAAYRALQSPKPTYRHFLTENAPEDDEVWQSRLRLLQLLGGPHEYDIAAIRERMDKLSGDLLVPETIIIAGRERKHEDALRLLVHDLGDYDTAVSYCLRGGATIYSPVMGRRDSVPQVEQQRRLFQVVLREFLAIRDVSDRVEQTSALLDRFSGWFDIDDVLALIPDRWSVDVVAGFLVGALRRLVREKNEAMMVRALRGAENLRVSYDLVVRVGEKGATTVEEAPGEEVPSGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTQ6</accession>
    <name>A0A2T4BTQ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate-binding module family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_347571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTQ6"/>
    <dbReference type="OrthoDB" id="2131701at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23445">
        <property type="entry name" value="beta-trefoil_Ricin_HA17-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="134" mass="14758" checksum="BCE101A48DBEDCFD" modified="2018-07-18" version="1">MSFSEGTYYIATALSSHKAVDLDSEGHGGKNQQWRISKITHDEYSIQSIATNTYITASSGDDAAVHASKLIPEANNVSRWKIVKASKADHYHIYSVAHPNKVLDVTGSKQENSTPIIVYTYHGGPNQQFTFSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUM2</accession>
    <name>A0A2T4BUM2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATPase, V0 complex, subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1441248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUM2"/>
    <dbReference type="STRING" id="983965.A0A2T4BUM2"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB72946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8594" checksum="1098893154915412" modified="2018-07-18" version="1">MAQGYSIVIGLLVIVALSAAAWFLSPKGENQVLWRSSLILAIVSCYLMWLITFLAQLHPLIAPRRSNLREEFVGHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV11</accession>
    <name>A0A2T4BV11_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1383277</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV11"/>
    <dbReference type="STRING" id="983965.A0A2T4BV11"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="43"/>
            <end position="418"/>
        </location>
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        <location>
            <begin position="193"/>
            <end position="376"/>
        </location>
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        <location>
            <begin position="455"/>
            <end position="518"/>
        </location>
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            <begin position="557"/>
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        <location>
            <begin position="639"/>
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            <begin position="686"/>
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            <begin position="1064"/>
            <end position="1149"/>
        </location>
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            <dbReference type="EMBL" id="PTB73086.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1157" mass="130736" checksum="068AA56682D468B8" modified="2018-07-18" version="1">MPLMDDGFEALLEPFYNGKKLTDPISTKEDKFQLLPAFLKVKGLVKQHIDSYNFFVEHEIKEIVRANRTIRSDVDSNFWLEFTDIRVDRPRRLDYNDSKSRTEVTPMECRLRDMTYAAPIFVDIAYIRDKQKIVRKNVPLGRMPVMLKSCKCRLSGANNSQMEQMNECPLDPGGYFIVNGTEKVILIQEQLSKNRVIVEADEKNNVISASVTSSTHERKSKTYVTLKKDKIVLTHNILVEGVPIVIVLKALGGLSDYEIMQLVAGSDGRYQDEFLVNFDEAAKAGIFTQQQALEYIGSRVKMGSRKGQFGAQARRNNVEEGLDALANLIIAHVPIEGLDFYPKAIYVAMMTRRVLMASQDPKLVDDRDFVGNKRLELAGQLLSLLFEDLFKRFMSEVKMSIDKFLKKNNRAVPLDAVHMISNHANSIGLGINRAIQSGNWTVKRFNMNRAGVTHVLSRLSYISALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTNVDEAPVMRWIFTLDVGVEPIRNFSGAEMHREGSYIIHVNGTPFALTRYPKRFTHRFRTMRRRGWISPFVGIHTNSHFNAIHIATDEGRICRPYIIVKNGKQKLKPEHLRLLQLGKVTFDDFLTKGIVEYLDVNEENDALITIYEDQVTMSTTHLEIEPFTLLGAVAGLIPFPHHNQSPRNTYQCAMGKQAIGAIAHNQFNRIDTLLYTLVYPQRPMVITKTIQLIHYDKLPAGQNATVVVMSYSGYDIEDALVLNKASIDRGFGRCQVFRKYTTELQKYPNGRRERIGDPLNEIENGVMRRIKKHEALDADGLAVVGQRIHSGEAMVKKETPLDMTTTGIGLDRGPSEYRDTAVSYRIADPAYIDKVMISQTEKDTTVIKVQTRQTRRPELGDKFSSRHGQKGVVGIIVDQEDMPFADSGLCPDIIMNPHGFPSRMTVGKLLECLTGKASIVHGRKEYGFGDAFRSHPVEQVSKVLVDHGFSWEGKDYFTSGITGEPLEAYIFNGPIYYQRLKHMVQDKMHSRARGPRAILTRQPTEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMLSSDGVMIDICQQCGLFGYRGYCGTCKSTREVTKMQMPYAAKLLVQELISMNVGVRLQLEDEFPHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVV5</accession>
    <name>A0A2T4BVV5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1404448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVV5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="54" mass="5506" checksum="A4D222AE70826525" modified="2018-07-18" version="1">MSPRCLVASSPCLTCCASSHLISVSVLARSAPTLLLPMTPGRTALTPSPPVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVV9</accession>
    <name>A0A2T4BVV9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1393964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BVV9"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="KsdD_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="3-KETOSTEROID-DELTA-1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260:SF1">
        <property type="entry name" value="KSDD-LIKE STEROID DEHYDROGENASE RV0785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="261" mass="28739" checksum="186A1243B09027F5" modified="2018-07-18" version="1">MGSEEEQKPVIIRFPPYLFPGSDTLGTLRAICATGYDYSWFILDQSIIAREFALSGSEQNPDLTSKSIWELLKNRFFSTKGTVNVQLFQENGKDFVVRDTLKELVAGMNELAKERNGPVLDYDKIKEVVDARDDQFNNAYSKDAQAMLIHNARSYWIDKRSRVATPHKLLDPAHGPLIAVRLNLLSRKTLGGLETNLSSNVMRKDMTPFPGLYAAGEVAGFGGGGVHGYNSLEGTFLGGCIFSGRAAGRAVADELAEVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW87</accession>
    <name>A0A2T4BW87_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1909-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1424859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW87"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8164" checksum="CEA7599FED84BF05" modified="2018-07-18" version="1">MGNGAKAQQKRERNNEKGGKAAKSQLKVNAQAMDIQCQICKSTFLKTTKAPALTEHAQNKHSKGLADCFPTFAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWB1</accession>
    <name>A0A2T4BWB1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1404609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWB1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWB1"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="14769" checksum="E739272C420D5B3A" modified="2018-07-18" version="1">MSENPTTNGHDALEEKLGRLSRKPGVKASIVLDRTTGAILKTSGQVDALQTAKSRTASTAASFSNDAPAAEEGEAHGVEEFALMIWTFVNSSGQLVQDVDTEDELKLLRLRTKKQEIVIVPDQKYILTVIHDTHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWF3</accession>
    <name>A0A2T4BWF3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_7335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWF3"/>
    <dbReference type="STRING" id="983965.A0A2T4BWF3"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015675187" evidence="1">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="31"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="286" mass="31320" checksum="C28DF8A2BC5E269B" modified="2018-07-18" version="1">MHFQSLASVVLALAIPSARATLSPNIPGMNLVWQETFIGNQGDMVDLSQWTVVTDLHNNQELETYTNLPSNMQLSGGQTLQLVPQKSLLGEWTSSRIESVQAWTPSPGKTMQVQAALRGGDSSLDQKAGMWPAFWMLGDSMRHGTPWPLCGELDIFEQINGQLTGYGTVHCDHTGGGACNEPSGLGESIAIPQDDQFHTWTLKIDRSSNYWQTETIQWFMDGTLFHTLTGAQIGDEGLWATLAHSPMYIILNLAVGGTWPGDPTEATLSGWGNMFEVQYVAVYESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX36</accession>
    <name>A0A2T4BX36_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_123098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX36"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="182" mass="19860" checksum="FEF460D391C3D9C1" modified="2018-07-18" version="1">MLSAELQSQRAIGDGLRLGNRKPPPFTRQGAVTGRFVARCVCRHEGASLYHLTVAQRHRSGFPRVVVWQSWWARRSSAGSGGLAWFELLVVSHLRHRQPYVLSPILLSCMYTLGGGASPALHMLDLSHGQTFTETEISLPRQGRLLGPWQSALPVAGCSSPATLMDSISSTATLRCLRAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXM0</accession>
    <name>A0A2T4BXM0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1338394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXM0"/>
    <dbReference type="STRING" id="983965.A0A2T4BXM0"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="339"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="414"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="560" mass="61637" checksum="48313FB6F2969617" modified="2018-07-18" version="1">MANSSSRLAWSKSTRIKVMIAIDTAFFLLELICGFLAHSLALTADAFHMVRCAIPSPFFFFFFLWRYYDDPRPGSYQLPFSQWVRAEILGAFFNAVFLIALCVSIILEALTRFVEPPEINNPKLILIVGCAGLFSNLLGFFVLGGHGHDHGDDHDHDHDHEEGHAHGHDHAHSHSHSHGQRDGTRSIADENGPVGDVLPEVVVRRASMIGDESNTRASRASQSRGRDHQRQSTKGHSRFSSIEDMSIHPASFRQEILAVSRAASHNICTNGSGDESAGSDTESGPNETSPLLQDTKSSRLPCSRRSTSKNSRGRRDSSVHIHNDHHHTLPIKPGSKVSGHNHADMGMNAMMLHVIGDALGNVGVIVTALIIWLTDWPGKLYADPAVSLLITAIILKTSIPLTIATSRVLLQATPENISIPHIRQDIERLPGVVSCHHIHVWQLSDTKIVASMHLQVSFPFDKNSGEKYMQLAKRARRCLHAYGIHSATIQPEFCLDNKHQHDGDAAALALDGASDEQLRPCLLECVDDCQAEGCCIVESSSACSSRRDSASSHEEHQHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXN9</accession>
    <name>A0A2T4BXN9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1338430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXN9"/>
    <dbReference type="STRING" id="983965.A0A2T4BXN9"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="249" mass="28051" checksum="C89F34511177E7A2" modified="2018-07-18" version="1">MDQQVDLTSIPISPSGDEHAGETKENKDDGKPVTVFHDKDNFTVKHPLQSKWTLWFTKPPSGKGDNWNDLLKEVITFDSVEEFWGVYNNVAPVSELALKSDYHLFKAGVRPEWEDPQNKHGGKWSYQYKDKRNVDVDRLWLQVMMAAIGETLEEEEDGEVMGVVVNVRKGFYRIGVWTRTIGKSIPGRGDGDVAGGKGRSNEKGKEILMNIGRRFKETLELPANEQIEFSGHTDSAHSGSTRAKAKYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXW8</accession>
    <name>A0A2T4BXW8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1403532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXW8"/>
    <dbReference type="OrthoDB" id="5328813at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="37588" checksum="634FCCC6BC71C04F" modified="2018-07-18" version="1">MNTSEKRRGGGRSNSTGPDRRTGQTTHSSRHGSSGGGAAGGGGGGGGGGANTATNGAGGNNSDNLPVMPPRAAMTGTSSTGADDSHNAGGTLLERKRKEKGQGKDGVPGSNNSSGTARGSSPHGSNPSGSPVSKQHRRQQHSEAAATAHLLREKDERIAYLEDEMAIMEREFHRELDKLSQAESETATFWQGKHSALNQQYLRTDTELRLLRAEVDVREAEREELRQGVEVLRRELQERDDEIRRLRGQVRGLKDFVSTSTRTDDQTSDEVFGDGMTKLGNGLQNWVITNFRKAKLDLSKASDDTLAELSRLVPMYEDVIKHGDENGGHMQYRNVIVKARVLCSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY36</accession>
    <name>A0A2T4BY36_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1337909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY36"/>
    <dbReference type="STRING" id="983965.A0A2T4BY36"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="427" mass="46202" checksum="B215B3503E4583E3" modified="2018-07-18" version="1">MGSVPESVPAVRVFIAGGSYAGLSAAVNLLDLGNGLSPRMSSEPYAHHPSVPKVNFEITIADERDGYYHLIGSPLAFADADYAKKAWVRFQDIPGLQLPNVKFVQGSVSSVDCAAKTATVIDGTTKEAATYPYDYFVTATGLRRVWPVVPQALTQKQYLVEAETQIKALENAKDGVVVVGGGAVGIEMAAELKHVKPHLKVTLVHSRDRLMSSEPLPDDCRDKALEMVKETGVEVLLDHRLASSTKVDTSDGSPKYEVEFTNGHKMTASAVIMALSNSTSTASYLPSSATDSEGYVKIVSNMSFEPDSVPNASSHFCAGDVARWSGIKRCGAAMHGGHYIAHNIHQSVLRERDARHEPRFQHLREIPPMIGLAVGKNAVAYSPEGGLSSGPEVMQAYFRDDLGWAICWEYMQLDGRKPEVKLQEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY38</accession>
    <name>A0A2T4BY38_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1042614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY38"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18054" checksum="5B43BD544AEAC65A" modified="2018-07-18" version="1">MTSGERRKEWIPGSPPASCSASGSDVCQKLGRWIAIRRRYLMSNHPIFASFAEAGKEERQRVQVAKRFPFRILAILCQVNGATSNTPVQGLGASSDGGLFSEEVCVVNNARHFRVASVAALSSRADKPMHQQRRALLRVIGALLCVVETCPRRGNKYRFVPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY49</accession>
    <name>A0A2T4BY49_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1403606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY49"/>
    <dbReference type="STRING" id="983965.A0A2T4BY49"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="412" mass="46980" checksum="8DE4E4E603AD25E3" modified="2018-07-18" version="1">MPQLPDKDPKEGEPAVVFPPVTRDHIQNCSYEAWFPKYRSSCLKSRIIPLPPAFVSYLHEDGIILADDDEANEPEDTEWSTPAATHPRVTPYDSSDDEDEEEEERLPPNKRFPETHELIKQKIAELGGAVAPKLNWSSPKDAKWISPHQNTLKCTTPNDIYLLLKSSSFVSHDLLHAFDDCTDAPPARPFKPVLVLRPFFTPHVALEFRCFVKNRSLIGITQRDLNHYDFLERLQGQLWKKIRTFFYQKLRLTFPDPCFAFDIYIPGNTFAEDGLGKVRLMDINPWAPSTDSLLFSWEELLTMEPENPLYGSVSEEQADGSGGETADETDDEAENEYSPDRQPEIRIVRKNDPEAYNFSSPQYSAHKLPKEVVDASLAGEGGLREFAERWKEITEGRGQGIWEQPSNLNART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYG6</accession>
    <name>A0A2T4BYG6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1043246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYG6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8529" checksum="D9184BFE284912BE" modified="2018-07-18" version="1">MSFTRGQPLRTRHIPHGALLLCAVPSGPSRVPIGRDISRVPHPELRSTQLRHRYSASLKNIPKEAQALRKGSVQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYN4</accession>
    <name>A0A2T4BYN4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1338131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYN4"/>
    <dbReference type="STRING" id="983965.A0A2T4BYN4"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="60338" checksum="7A27143C5903D83B" modified="2018-07-18" version="1">MGLLESLDAGLTGFVGQWNGYSTALVTLLVLLVTYRITTSREPDVHPLLLARQAGASTVRNEGESAAYRCLAAPHSMPLNSGLDIKDPGVSKWSRGRNGDLRDIWRKAVAGNAEGKKGKLLTVLGSEKVIEHRLEDITRQINLIGHYIAEQGGIRVAIYLPNSVEYLVALLACSFYPNLTTVLIPFNVSNEELVSMMRRSAVDTVVTTPGSFPLDDVAKAYPSLRQLIWVVDEGSSHLDWNEVPEGTGGSVNVATWQEIIRDAPADAGTELPPLNLEKVPMDVVTFWQTKPGQLEEMVRFTQSNLVAGIASQINAIPIKERLTPSDLFLPAESLAGIHTLSLTLAALYQNSSIAFNSVAGQSPDLILATQGIAPTVIVASPSSLLKVHEESIAKLNSPLAKASHAIATRTLTQHGVLPTANLLSPFAARAKPSLGTDPSKLRLVYTAERVGADTPHLSSQVLSDLRVFTGARVVYALTSARVVGAVSQTAYYDYRVEEGDKGHFGAPATSIEIRLKDKGQYKTTDDVVIGEIYATGPSVAGGETNLGVIGTFRHDNTLAYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZU7</accession>
    <name>A0A2T4BZU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1336449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZU7"/>
    <dbReference type="STRING" id="983965.A0A2T4BZU7"/>
    <dbReference type="OrthoDB" id="5298304at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="549" mass="60197" checksum="06F84A6D0B53C0CB" modified="2018-07-18" version="1">MASQAAPPEGEFKEANATQSVARSPSASSQRPKGNDEGGIRPVDADYDTETVERVYRKIDLRIIPPFWILYFLCSAIRSNIGIAQTMNSDKGHDLETVLGLTPKDVSTALALFYVSYVIFDFPSNLIMSKLSPRVWMARIVFATSIVGSCFAAVSSPWSLKFLRFLLGLVIAGMWPGMAFYLTLFYPPSRTAKRIGMYFTASQVSAAVVGLVSAGFQLMDGDCGLVGFRWMFLIYGLVGVVLSVTLLWWLPDRPLAPGQERKRTGLFRWLPATPEVLKGQDAVVHYSELKRVYHARPWGLKDLGLVLLDWRLWPLCLMYFGVVGVGIGTQLYGSVIIAAIQPQASDIVVSLLFAPIWIMDLIAILLVTPVSDRFHRLRPLFFSAAVCIQIAGLLMTTFAVQNGWARYGGLLMVGFGLGPTVPICMTWTSEIFQRRHGEVGVAAATALVSGLGNLGSVTTTYALYSGWPEDAAPGPHRFRKSNLTMIGILCLSILSSFVMWALLKVVGNPPSSKLHGGDSVSEFEDGAARREATQRGFGKASRRAQTEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZU9</accession>
    <name>A0A2T4BZU9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1403309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZU9"/>
    <dbReference type="OrthoDB" id="3938544at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="196" mass="22221" checksum="6E00FFD359A1B6C5" modified="2018-07-18" version="1">MLTPHHNLSRTLFILKNSRLRRGCARADPRILRAESFVHSPALGPAAGLTIPLPNFSTKVYIVKPTITMSDGDENDLFNIQVSDSEEDQVEKKSKRTGQSEDEFQAVKNAYRAKVENGNIHETINLPLAPDANKQHVQEVIHATEELYFFRRYQDVIDLVSRVLALEGDKGGLDDESKQLLSMYQSRCRQKLKQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C099</accession>
    <name>A0A2T4C099_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSCRP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1393193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C099"/>
    <dbReference type="OrthoDB" id="4894650at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015400050" description="SSCRP protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="11971" checksum="7A19D76D2F600680" modified="2018-07-18" version="1">MKVFALAFALVGLASAAPSAIATVEYEQWWDPGCQGRALLGGTLAQGYCVRTENFPGQSVKLTVTSPCPEGTSPQVTVSSSDDCDNGPIDWTFGATGECIDVSIQPISFHLNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0B3</accession>
    <name>A0A2T4C0B3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1402583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0B3"/>
    <dbReference type="STRING" id="983965.A0A2T4C0B3"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="7">
        <location>
            <begin position="75"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="565" mass="61630" checksum="C58B94DA64C50E39" modified="2018-07-18" version="1">MPLTKERLAKTLGFKSEDRDSDVPSISNADPFIEREPTVGEFLEEIRPSLHDVGRYFYNMFPFIHWIGKYNFTWFFGDLIAGITVGAVVVPQSMAYAQLAQLPVEYGLYSSFMGVLIYWFFATSKDITIGPVAVMSQVTGDVVLRAADRLPDIPGHVIASALAIIAGAIICFLGLARLGWVVEFIPLPSICAFMTGSAVNIAAGQVPKLMGIKGVNTRDAPYKVIINTLKGLPTTSIDAALGLTSLLMLYLVRGVCTHMAQKQPHRAKLYFFISTLRTSFVILLYTGISAGMTMHNKTHPRISILGKVPRGFQHASVPEINSSIVEAFLPDLPAAVIVMLIEHISISKSFGRVNNYIIDPSQELVAIGITNLLGPFLGAYPATGSFSRTAIKSKAGVRTPFAGVITAMVVLLALYALTAQLDRYAAPHTVDWHFAHIENRWTKRALAAAGFGYRTPRHIAEDNGEGAGHWKTIFSIADLGGSDSAAAAAAAEEKASRVQYDVERTHSDDISKASDEKDVPAHPSSRRLVAIRGLNRPYFHFDLQEAVESAIANAERYRQDDDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0G1</accession>
    <name>A0A2T4C0G1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1268005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0G1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="792" mass="90166" checksum="35E14488DE66FD8B" modified="2018-07-18" version="1">MTRVYRVHEKDHNFPSIIIHKIKAFLENESVFSNPEKHQHLIQEMKLEAALVTSNSPYAEVRAVVSNKDDPTTPCSTIRSWAIGLAFSCLLAFINQLFDIRQPAIRVMANVAQLLSYPVGKACENWLPDIGFTLFGTYHSLNPGPFSKKEHMLITIMANVAYNTPYTNNIIWVQYLPQYFNQPYASHVAYQLLIALATNFIGYGMAGICRRFLVYPSYCVWPASLVTIALNKAFHNEANAPVEGPFGRKWKISRIKFFYIMFGAMFVWFWFPNYIFTALSRFNWLTWIAPHNRDLNVITGINHGLGVNPFPTFDWNVLLWDSADPLMVPFYSTLNRFFGVFVSFWVVLAFWYSNVYDTGYLPINSNRVFDHFGKLYNISRAVDDRGLFDADEYKTYSPPFLSAGNIVIYMFFFAIYTSTLTYAVLYHRHEIIMGFKSLFASFRKKKNPIKDEKILDVHNRLMKAYPEVPEWWYLICLVVAIALGIAGIAGWDTNTSPGVVFYGLALCIIFVIPVGIIKAMTGIEVTLNVLAEFIGGSFVDGNALAMNYFKSFGYVTCAHAVWFCNDLKLAHYVKIPPRHTFIAQIIATFISTIICTGVLNFQMKGIDGVCTPDAQFKLTCPGVNTFFTASVLWGTVGPQKIFGHSGQYTEILVGFPLGIVVVVFFWGLNRKFPQWTWTRQIHPVAIMYGGIVWAPYNMSYVWPSVPIAWISWVYLKTRFVSFWSKYNFVLSAAWSCGIAISGIIIFFALQYTDVPFQWWGNMASDMGCEGQACTLKHLAPGEYFGPRIGTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0H5</accession>
    <name>A0A2T4C0H5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0H5"/>
    <dbReference type="STRING" id="983965.A0A2T4C0H5"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="458" mass="50870" checksum="6A88574E65A60FC4" modified="2018-07-18" version="1">MSPTSTTHDAIEVPATRSPHADASKYMHNLSLSPSMRDRRASRNSFGASLPIPRSKRQSRLSSVHYPDRDAVLGKGVLPPQKTRDILAAQVQDISADKAKKAKNMAFVFDIDGVLVHGDRLIPEGKRALEILNGDNELGIKIPHIFLTNGSGKPELARTEQLSKILQNPVSTEQFIQSHTPMRALAEYYNTVLVVGGEGYRCREVAEQYGFRDIVVPNDIVAWDPTIAPYRVFTEEERASSRPRDFSKTNIEAILVFSDSRDYATDMQIIVDLLRSENGRLLTVAADPVSQRIPIYFSQGDMLCPTEHPIPRMSQGAFRIGLEAMYKALTGVDLERVVYGKPEMATYKYADEVLASWMEQLHGEERIPDNIYMVGDNPASDIIGGNMYGWNTCLVRTGVFQGGDNDEANPANFGVFANVLEAVKAACRKELGESFGFEWDDRVNPVLHGEKHVASAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1T9</accession>
    <name>A0A2T4C1T9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1402068</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1T9"/>
    <dbReference type="STRING" id="983965.A0A2T4C1T9"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015463050" evidence="12">
        <location>
            <begin position="20"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="153"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="14">
        <location>
            <begin position="366"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="15">
        <location>
            <begin position="611"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="882" mass="93023" checksum="B41B4F2A33859505" modified="2018-07-18" version="1">MVRSALFVSLLATFSGVIARGSGHGSKVVPGAYIFEFEVSQDTADFYKKLNGEGSTRLKFDYKLFKGVSVQLKDLDNHEAKAQQMAELPAVKNVWPVTLIDAPNPKVEWVAGSTAPTLESRSAKKPPIPNDSSDFPTHQMTQIDKLRAKGYTGKGVRVAVIDTGIDYTHPALGGCFGRGCLVSFGTDLVGDDYTGFNTPVPDDDPVDCAGHGSHVAGIIAAQKNPYGFTGGAPEVTLGAYRVFGCDGQAGNDVLISAYNQAFEDGAQIITASIGGPSGWAEEPWAAAVTRIVEAGVPCTVSAGNEGDSGLFFASTAANGKKVIAVASVDNENIPSVLSVAAYKIDSGAAQDFGYVSSSKAWDGVSKPLYAVSFDTTIPDDGCSALPDSTPDLSDYIVLVRRGTCTFVQKAQNVAAKGAKYLLYYNNIAGALAVDVSAVPEIEAVGMVDDKTGATWIAALKAGKTVTLTLTDPVESEKQIQFADNPTTGGALSGFTTWGPTWELDVKPQISSPGGNILSTYPVALGGYATLSGTSMACPLTAAAVALIGQARGTFDPALIENLLATTANPQLFNDGEKFYDFLAPVPQQGGGLIQAYDAAFATTLLSPSSLSFNDTDHFVKKRQITLKNTSKQRVTYKLNHVPTNTFYTLAPGNGYPAPFPNDAVAAHANLQFGLQQVTLPAGRSITVDVFPSPPKGVDARRLALWSGYITVNGTDGTSLSVPYQGLTGSLHKQKVLYPEDSWIADSTDESLAPVENGTVFTIPAPGNAGPDDKLPSLVVSPALGSRYVRVDLVLLSAPPHGTKLKTVKFLDTTSIGQPAGSPLLWISRGANPLAWNGELSDNKFAPPGTYKAVFHALRIFGNEKKKEDWDVSESPAFTIKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C230</accession>
    <name>A0A2T4C230_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_326125</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C230"/>
    <dbReference type="STRING" id="983965.A0A2T4C230"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
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        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
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        <property type="entry name" value="Znf_TFIIS"/>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB75623.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="14508" checksum="8F66288CB08C809B" modified="2018-07-18" version="1">MASPQSTTTDDAGSRKHEQITFRFCSECSNMLYPKEDEDQRKLQFTCRTCQYTEDAQSTCVFRNVLNSSSGETAGVTQDVASDPTLPRSNKTCPKCSHQEAVFFQSQERSADTGMKLFYVCCECGHIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C243</accession>
    <name>A0A2T4C243_TRILO</name>
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        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1402162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
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        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="148"/>
        </location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="407" mass="43380" checksum="033C9EA8B8986725" modified="2018-07-18" version="1">MPLHLPTPKFLHGLPSNSIRIIAILIAVNALVWIAVGIVLHFHPALISPAALSYALGLRHALDADHISAIDLMTRRLIASGQRPATVGTFFSLGHSTIVIITCIVVAATSGALRKRFDGFQRVGNIIGTSVSAAVLIILCVGNGWVLYKLVKRLKEVLAQRRRRGDGQQGEVDAAGVAAAAYANDQLQLEGGGFMIRALRVMLKTIDRPWKMYPLGVVFGLGFDTSSEIAVLGIASIQAVQGTSIWLILIFPILFTSGMCLVDSTDGALMMALYTSKAFSRDIVAILYYSIVLTGITVVVSAFIGIIQVLSLVQNVADPSGSFWDGVSAVGDHFDIIGASICGVFVIVGIGSVLVYGPWRRRMERRNMAVLADEEGEDGGGEVEREMPPSAEQGGSPKMASTQVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2K6</accession>
    <name>A0A2T4C2K6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1260575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2K6"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="285" mass="30967" checksum="3C2A26100DAADE47" modified="2018-07-18" version="1">MPSPETAATDATVEQPAESPAAVASDSVQQEAAGDERVEDSDVEAGEVTQEDESDGERDANSNDKSPEESSRADATAAGEAPPLPNEAVPDGPPLPDEPVPQQPEDDGWDCQWDPNSQAWFFYNRFTGKSQWENPRVPGANSAAVVSHVVAPQPPAHEKPVAGGYNPAIHGDYDPNAWYAKMDEEPEDTTGLVGDPAAIYAATATFNRYTGHFQAGEGAERHSDEAKSKRQMNAFFDVDAAANAHGGRSLKAERSNKKPTKNELKAFKEKRRARKEEKRRAWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2N0</accession>
    <name>A0A2T4C2N0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1439461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2N0"/>
    <dbReference type="STRING" id="983965.A0A2T4C2N0"/>
    <dbReference type="OrthoDB" id="5424147at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28696" checksum="5A4D1F00F36B63EB" modified="2018-07-18" version="1">MSDKLDTVYYMGAPEHVSQQTPSMAPPKYVHHFDSYSLVKQLQEGGYRGDQAVTMMKAIRTILAHNLDMAQERLVSKSDVENESYLFSAACSELSAEVRNNRRAQDEQIRQQRTHLQHEVDILTQTLNQELLTLNDNVRGLFNDRKMTVREEQKAMESAIQQINYKISIMLSSDSKSEIEGVRWILIRRSVVGILFMAICMLGTIRYATYVSHERQREADRKKKEEEELRKDGGKNDRSSGPDAAAILAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Z4</accession>
    <name>A0A2T4C2Z4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1423022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Z4"/>
    <dbReference type="STRING" id="983965.A0A2T4C2Z4"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="13642" checksum="0AC3A03DB273A9A6" modified="2018-07-18" version="1" fragment="single">SAPAGAATARTTTPRTPSFITAEDRIRHIKATHMHVGRDAGGTYSGHASLAGSDTEASDDDEAARRLRQRQRIASASSSSLDARIKSGSALANRLGDEPGTDGSAAEHEGEEDLDEVERHDRSVRGSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C447</accession>
    <name>A0A2T4C447_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1250810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C447"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="170" mass="19508" checksum="ACF0EA0C7CFCEFFB" modified="2018-07-18" version="1">MTGENLLYILKGYCWPPVATRPNYVGIRRDDLSLRQTETAVILTKPPRKLRIYSCEYLDNVLIWFIRQVQEIISAPTTRTALTADEIKPCDPTCSTWWCFGNRQTNVFDQTPHGRKPSMPGLRERISRVTRSSDNYTDSSKRVICRGAQSEESWRGERRGSIPAGGIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4G3</accession>
    <name>A0A2T4C4G3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4G3"/>
    <dbReference type="STRING" id="983965.A0A2T4C4G3"/>
    <dbReference type="OrthoDB" id="4207123at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="162" mass="16309" checksum="928025184B120E37" modified="2018-07-18" version="1">MPSQRPFFLSSFFNSFRQQAPSLTQQASKHSSQAASASAAAAAAASTTAAAAAASASSSGASSAARAISTSAASATATATSSSSTNVAIHTPRGSPGGAIPIPHGSRRRGSDSSSEGFRDALGADKWYIGGRTAAGEEKFFKLGVIRRVRSNDGLSLDRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4G8</accession>
    <name>A0A2T4C4G8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1439136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4G8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4G8"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041188">
        <property type="entry name" value="HTH_ABP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18107">
        <property type="entry name" value="HTH_ABP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="41545" checksum="FAD0D2EF825069FD" modified="2018-07-18" version="1">MAATTDSLVDGSDLSPSAAPKERHSLTLDQRRALRRWANSQTIRPSHKACIEWFFGQYGQQISQSTVSHSLSPKYSRLDGDNPQLSGSRLRFGNWPDVEKLVLLWYQQVQAAGRQPTNEELGEKAKAIFSQLPRYKEETPPEFSPGWIHRFKKRYGLLIRRQRRHGDGGINPADDIDYLADCVPRFMAIAADTSPAAIREQVLRVVGVESSLNTCALVRDEIIRRLASAHAQPLPSLAPVEPTLAQPQPDQPMYADDDPEVVLQNALRQLQQEEQAAEEQAAAVREERERAERAAGLQQQGLTTPGGRAPSDTRYTTPGQDMAAELTLTPIHSDVPLSTHGERPLRCPFCVNQRMLRSIKEAVEHMSTHVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4S6</accession>
    <name>A0A2T4C4S6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1463224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4S6"/>
    <dbReference type="STRING" id="983965.A0A2T4C4S6"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="224" mass="24539" checksum="8EE1DDF82F984386" modified="2018-07-18" version="1">MVFTKLVIAGSSGYVADYAIRAIMACTKPQFDVTILTRRKGSAESPSIPGARVIPVDYFDHDELVKAVAGADAILSFISGLASKVIDKLLLKAAQEAGVRRIFPSEYTLDILHPEAVKLLTEGGDWPEDSSPTYMKRFWVRPFERSQVTSQELLEQRNANLQSGNHVDALLAMIHLAAFNGSGAADLVDGLKFDGDGYLRTQRKTLRRLTVESLRRIGITSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Y0</accession>
    <name>A0A2T4C4Y0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1400987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Y0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="16622" checksum="B6967B8FE29CB03C" modified="2018-07-18" version="1" fragment="single">MPISPGLASSHHTEKYLVSLVNFLVFVFVFHVRDRDGASVVDLCVTLGRPGDCTRPWSLVPSSSCPVATSITALKPCPPLKVSPSPSFILASPQGGPSRTDPAHREWIVPKCRLSAKEKVQELLLRVFFSFSWPKLPCKLLKKVVRLECAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5M6</accession>
    <name>A0A2T4C5M6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0005-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_19162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5M6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5M6"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="276" mass="30792" checksum="5CBF6C1B1983D9E7" modified="2018-07-18" version="1">MASTTKYQPAPQQEPDDDYTQAPPAYGTAASSSHHDPGLFAEPRSSDDNIPDDFKFGGSVAEATVDIRNQFVRKVYSILTVQLVATAALSSISFFSDAYKSWIQSHPGLVWASLFGAMIFMGLTYWKRKSYPTNLLFLALFTLTEAYSISVIVSFYQTSIVLNATVLTAGIFVFLTLFACQTKYDFTSWMPYLFGALWGLVIFGFMSMFFPYSSTADLIYGGLTALIFSGYILVDTQLVMRHHHVEEEIAAAISLYLDIINLFLAILRILNNQNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5U2</accession>
    <name>A0A2T4C5U2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5U2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5U2"/>
    <dbReference type="OrthoDB" id="5233393at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015427312" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="37344" checksum="0478EC06D497BF12" modified="2018-07-18" version="1">MALRSVALFALCGASLALPSAPPLRPVSTLFEFPKPSYIENLAVRSNGQILISDLSTSQLTLFDPSASGPKETVFVHDFTESLGLAGIAEYQPDVFAVITGNVSLTSDDVQSAGTWIVWSVDLRGVEVSSRHGKAELTSPPVVKKIAHVKPADFLNGISVLSEKDKTLLVGDVNGGVIWRLDIKTGHYEVAINNTYTQLYPATPFSASGVDGVHVRDGFVYFTNFGNGTFNKMPIHSDGTPAGPVTTIARNEGLFHEYDDFTFDCDGNAFVVTGGANTIEMISADGKRQVVIAGSLNSTAIAEPTSCAFGRGPHDKNILYVVTAGGMETPVDEDVVIGGQLVAVNTTSRGSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C687</accession>
    <name>A0A2T4C687_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1422113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C687"/>
    <dbReference type="STRING" id="983965.A0A2T4C687"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="281"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="537"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB77081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="624" mass="69098" checksum="8D0BC0DB8B212B5C" modified="2018-07-18" version="1">MRTKLKDTHLGPLSAFSRSPSTSTITDKDEKGTSPGATTPTSENAIAASEALSQAPVVKKPGILVVTIHEGQGFSLPEQHRSAFASSHQSSRSSGGALAGSVRPDGQRVAGSYTNGARPHSSGGGFGSLPTNHGRISGKYMPYALIDFDKVQVFVNSVEGSPENPLWAGGNTQYKFDVSRVTELVIHLYMRNPAAPPGSGRSQDIFLGVARINPRFEERQPASDDAKTSKKDREKAADAQRQKGEGHSGVEWVDVQYGTGRIKVGVEFVETRAGKLKIEDFELLKVVGKGSFGKVMQVRKKDTNRIYALKTIRKAHIISRSEVAHTLAERSVLAQINNPFIVPLKFSFQSPEKLYFVLAFVNGGELFHHLQKEHRFDVNRSRFYTAELLCALECLHGFSVIYRDLKPENILLDYQGHIALCDFGLCKLDMKDEDRTNTFCGTPEYLAPELLLGQGYNKTVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILSEPLHFSDVVPPAAKDLLTKLLNRDPKKRLGANGSAEIKAHPFFHDIDWRKLLQRKYEPTFKPSVTDAMDTANFDPEFTSEAPQDSYVEGPMLSQTMQDQFQGFSYNRPIAGLGDAGGSVRDPSFVGSLQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6E4</accession>
    <name>A0A2T4C6E4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_52522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6E4"/>
    <dbReference type="STRING" id="983965.A0A2T4C6E4"/>
    <dbReference type="OrthoDB" id="4894665at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="11707" checksum="0BBD603E0C23C3E5" modified="2018-07-18" version="1" fragment="single">MLQLAWDYANGSISEETIGNALYNATDREKVSTVRLLLQSFGASPNATGEEYGTALTAAAFDGIMEMVQLLLDAGAEINDPNGWALQTAAAEGHYEIVQELISRGAEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C727</accession>
    <name>A0A2T4C727_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1331032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C727"/>
    <dbReference type="STRING" id="983965.A0A2T4C727"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="425" mass="46963" checksum="96890F31A0AA5240" modified="2018-07-18" version="1">MSLATVNDPTRFEIRLLSPLGPDDSGTTLYDTIHNSLVLRHVVSYLPISSIVSLAATSRAFRTLLLETPGVFRHLALSHIKAVQFEIDKIDHGGEIWRNVQLDENLTEDDFYSGPLRGIFSTLRRQNILQNVQTLILDGLSVTSELCHEIINDASFNVRILSIREVKNLNHGKLRQTLQYACRPTRRAGSPKLQALYVFGTRDIALASSLQHQGDVWWHEKGRMLPRPVSQEWASCMLACQGIIAFDAVLCHGPRHRNSPAYRGGSDADSAPAVATYSLAGCESCHGAPEGLTRPDSSNVARLPLLAPLPILSSSLRAAIKPRDPDSSFVPRCMDCIRERYCLSCDKWWCESCYHLPGQGSGITISHLSKSCWECGSNCESCINSTQRICKKCCAGYCLIHNEGCTMNHVSCLPATSPSRSLLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7J4</accession>
    <name>A0A2T4C7J4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1330982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7J4"/>
    <dbReference type="STRING" id="983965.A0A2T4C7J4"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20436" checksum="D10E36F97F70A4A8" modified="2018-07-18" version="1">MPSTLHKTRKQISKKRNGEVNALHEKSRDSFRLRKAGVRDQRLEKLAAARNKREQPIVERVTFFQQKVREQGSEPLEVAAVQAIIHTYVHQYDEEYEAVKKTRRAGRPASTKEDLLKIKIAALEKEYEAGFLIPDITTADGVKSLDAWEGSWAYLTSLPWIKVTAAGNVRKAELPSKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7M1</accession>
    <name>A0A2T4C7M1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1214260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7M1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="132" mass="15131" checksum="7E9CF4AC343F323B" modified="2018-07-18" version="1">METRSNGALAFQQQPPLRHSMEFYRKRVFPAFPALYSLPATFLDILSIPVVLLSRDFSPELIDCFYLHSHSSFILAPFMILATALLGVWSFDALVDMAQRTKGREIDEGVKLICCFGVYRWFSFGQYPVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Q4</accession>
    <name>A0A2T4C7Q4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1400531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Q4"/>
    <dbReference type="STRING" id="983965.A0A2T4C7Q4"/>
    <dbReference type="OrthoDB" id="2131339at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="POSSIBLE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="279"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="38769" checksum="7C22943A59B0B173" modified="2018-07-18" version="1">MPTVFQRDIILVLKSSDKNNDSYIRPRIAKMKDKNEVIQEFRELVNMTAQELKDWLKGDDSNSAGWSKDDGSGESVGHDSGRRIVEILESNPDKDPEKYTDDDVSHMRKVVSYCKRHLAQEEKANNKKSIEDVKKTKSYASLKNWGHDPIKKRQANGGGAKGKPDEKEEDEEEEVEEEEDKGDDKKQDKKQDKEEKAGEKRKAKDNQSGKNKKRETEDGAADVKEDEEEDEQEEEAEEEESNDKDDNEKEKQKKNGKQSGKQNGSSSGKGDSSKGPKEGDTVSWNWGGGQPKGKVKEVNPDETTVQTKKGSNVTRKGDKEDPAVVLDTGKTDAVKLSHELNETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7R8</accession>
    <name>A0A2T4C7R8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1374887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7R8"/>
    <dbReference type="STRING" id="983965.A0A2T4C7R8"/>
    <dbReference type="OrthoDB" id="5375886at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="69" mass="7550" checksum="B783A4459E272BB6" modified="2018-07-18" version="1">MPEGRQSPPPERQTGAQLQDPTGSGKGPNYDKSENKDPKSQLDKLTSNPKGPMDDVLEHKFSKEPGNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8H9</accession>
    <name>A0A2T4C8H9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1330734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8H9"/>
    <dbReference type="STRING" id="983965.A0A2T4C8H9"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB77879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="416" mass="45832" checksum="0423067977AB5FF5" modified="2018-07-18" version="1">MPSKFFVCNQCLRQAPRRSPSSILNIIRSRGYADAKPLESLAAQNASALASEAQGQASKAFPKKTTSKAVAIWLLGSAASCFGIVVFGGLTRLTESGLSITEWRPVTGSLPPMSAADWESEFEKYRASPEFKLLNPHMTLDEFKKIYFMEWTHRLWGRFIGLSFVLPSLYFVARRRVSPRMALNLLGISSLIGFQGFIGWWMVKSGLKDDLFAPGSHPRVSQYRLTTHLATAFVCYSWMLLSGLTILRTRRLLADPVAASAAIKAIRNPALNAFRRSVLGVTGLVFLTAMSGGLVAGLDAGLIYNEFPKMGLGLTPPKSELWDKFYARKEDGSDLWWRNMLENPSLKGTTGLVHLVSLQAALGISTLIYMVPIHLAATHQAGSLAVLTGALVLAHRLHVPKSTVRMIEQRLKQIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9F3</accession>
    <name>A0A2T4C9F3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9F3"/>
    <dbReference type="STRING" id="983965.A0A2T4C9F3"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF20">
        <property type="entry name" value="PHYTOCYANIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015418629" evidence="1">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="20417" checksum="49126B2E6F7A018A" modified="2018-07-18" version="1">MLFSTLAVAALSAVASAKTIRVDVGKSGFNFSPNDIKADKGDILEFHYHALNHSVVAADFAKPCQPKASGGFYSGFFPTGSGENKNVFQVTVNDTATPIWFYCSQTIGNHCSAGMVGAVNANADKTLAMFKSAAERQSSNQSPSTGPFGGRILSASAASQSSGGSSSTTTGSAAAATTTNAAASLGSVGGMALAVVGAAVAFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAT3</accession>
    <name>A0A2T4CAT3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAT3"/>
    <dbReference type="OrthoDB" id="5118341at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="342" mass="37994" checksum="B9C89FB2D9CE750C" modified="2018-07-18" version="1">MTQLSGLGEVRPRNGSRLNWEIGSLANYIRRLEFRPNTLVVLVCRHGAIEGMTDKIQDKGQVEALSRFKNLSIKVTDKLRLTAVLSVAEKSEAYDNLVIIASGFISHLYFDIGSKVTDLRIYRCATQPDLEEYLFVDGFSNFHGQPMLLWEGRHHEAQFWLGPGVVLDLGSHIGQLSILPDDSSVMSDFDQEKIRSNIEKMDQVEMEGSWWDNFRAPISAIVSILARVAKFAHAGYIKMTSGGMFVQYNFVGFALFSAAAAVAVDTVSAGAALLVAPGAAAAIYFIPWESVFGWLNRVVSWLRTGIKKIWEKVKDWLATFASTVRETLGLEGRSHGPVKFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAZ5</accession>
    <name>A0A2T4CAZ5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="15">PARP</shortName>
            <ecNumber evidence="15">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1461769</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="15"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAZ5"/>
    <dbReference type="STRING" id="983965.A0A2T4CAZ5"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17747">
        <property type="entry name" value="BRCT_PARP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="20">
        <location>
            <begin position="195"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="19">
        <location>
            <begin position="330"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="18">
        <location>
            <begin position="467"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB78739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="665" mass="73394" checksum="BF4D6876A03B1AA6" modified="2018-07-18" version="1">MPPRRKAAAAPAVPPLDGCVLAISGKFDTSKHTHASLEQLIRSLGGSVTKSVAKTTTHLVCSEDDFNSDSAKVAAAKTKDLPVVSLHWILEAEKLNKAVDPQPYIWGSAKAADSQADSKKRPLVVSKSDDDEEPEPKKAKTSTSKAKGAKGGKAKADAAPEPAPEAKEEKQVAEGQFIKKKDAAIPVDEHCPLLYNQVHIDPDTGLIYDASLNQTNASANNNKFYRIQVLYDAKSKQYKTWTRWGRVGEVGQSAILGNGTAADAIKNFEKKFKDKSGLAWENRGENPKPGKYAFVERSYNPDSDDEGDDDDEADGKAVKREDEDEVKPAECTLPLEVKSLMELIFNQQYFQATMTALNYDANKLPLGKLSKATITRGFQQLKDLAALMDDASLAASRWNTTVAQATEMLSNMYYSIIPHAFGRNRPPVIRDNVMLKKEIELLESLSDMKDAADIMKMDRKSTDNNIHPLDKQFQSLGLNEMTVLDHASSEFEHLEAYLHGSRGETHGHSYKVQEIFRIERQGENMRFDEYAPVSGYMFGKGIYLADMSSKSANYCCSYISGGQALLLLCEAKLGDPMQQLTNASYDAGSSAKKGGMESTWGMGMTAPPKWMDAGVVHESLKGIQMPDINEKPCATNVDGAYLQYNEFICYDVAQVKLRYLFRVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB11</accession>
    <name>A0A2T4CB11_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1429632</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB11"/>
    <dbReference type="STRING" id="983965.A0A2T4CB11"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="115"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="423"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="528"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB78730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="633" mass="72431" checksum="FDC28AB0BB66F029" modified="2018-07-18" version="1">MKHEELEAISGKLAGDFRTIEPFLRDLDKHLTLRSYLEGYTLGELETKIWQTLRANKVAIGFIRKNGLPNLTRWFTFIEQSHPEIQESPKADAAVKATKGGANYNLALQDTDKGVVTRFLPEPSGYLHIGHAKAALLSDYFGHVAYKGQMRLRLDDTNPAKEKEEFQDAIVEDLALMGIKPDSLTYTSDYFDYLYDMCKKLISMGQAYADDTDQETMRSQRMDGIPSKRRDRTVEENLRIFEEMKKASEEGLAHCIRAKISFDNPNKAMRDPVIYRCNIENVHHRTGTKWKMYPMYDFACPVVDSYEGVTHALRSTEYTDRNPQYQWFLDTLQLRQVHMWDFSRINFVRTFLSKRKLAKLVDAGLVWGWDDPRMPTIRGIRRRGMTIEALRDFIIRQGPSRNVVNMDWTTFWANNKKVIDPIAPRFTALLRKDLAKAAVTGPEAPAAVATEERPKHPKNASVGTKKVIFSNSLYIDQADAKSFKADEEVTLMGWGNAFVREISTSDDPVTSFKLELNLKGDFKKTEKKITWLSAEGFKLVPAELWEFDYLITKDKLEEEDNFEDYLNPNTASMEDAVCEAGVGELKKDDIIQLERRGFYRVDKGMNDWAEGEAGLKGPRVVLFSIPTGKTGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB93</accession>
    <name>A0A2T4CB93_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1328153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB93"/>
    <dbReference type="OrthoDB" id="544298at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="182" mass="19750" checksum="E56148BD625F6B2E" modified="2018-07-18" version="1">MSRLFPHTPYAEDQPLSHIILTTHVLTRAITTGSIIGLAIPSLRQSIPSLRRPGTPPFPEHVLLSVTRSTVLTTAIVSVGLVARMWGREPIEWQDRSWRLLENRGQLELDDWTYGGMGAALLATGLMRVRGAGGPARLGWRGVVGAAGMGSVGGMFGYMAWRYGVNGGKFVEADKKGERKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB96</accession>
    <name>A0A2T4CB96_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_269987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB96"/>
    <dbReference type="STRING" id="983965.A0A2T4CB96"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="537" mass="61215" checksum="A57FE4CCBD748BCB" modified="2018-07-18" version="1">MQISSSNMEAHDMEAHDKVVSSISSRVKHFHHLQKPFRIYHGATNSTRRSHRSPDNTIDTSPLSHVLSVDPASKTAVVEPNVPMDVLVGATLRHGLVPPVVMELPGITVGGGFSGTSGESSSFRYGAFDANVNWIEIVLPDGEVARASKTERQDLFWGAASAFGTLGVVTLLEVQLKEAKAYVRLEYSLARGAEDMLKRIQTACAVEENDYVDAIVFAMDTTVVCTGRLADEVPQGTKPVGFLGRSDPWFYTRAKDVVKQLKRAAEKGGDEKSVVVTDFVPIQDYLFRYDRGGFWTAVYAYRYFLTPFNRITRYILDPFMHAREMYRAVHKSGLADYYMVQDVGVPYDKVVEFQAWLDKELHIYPLWICPLRIRRDDPDSGHGLHSEFARPDVPDLMNFGVWGGVKGSRRDVIEKNRALERKVQELRGKKWLYAHAYYTEEEFWSHYDRSSYDALRKKYKAEYLPSVYDKVKVDVEGEERARNATWRTRWRARVWDLWPLAGLRGFYSAVKGGDYLLQRRKGTDDVVRAEVEVGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBC2</accession>
    <name>A0A2T4CBC2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1420863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBC2"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="329"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1026" mass="115156" checksum="7DA7AE0A4EF1FEE3" modified="2018-07-18" version="1">MRRLAIRLFRNSSNEPTCDTKAAAVTPNPDNDTQLGSVFWPIELIPEECPNSRILMFGYDSKITKYMAGATNQNGIFSHAKDLLFGLSRERRFDRPLVFVAHSLGGVIVKQMLAESFSLSETPFINIVKSTAAVIFLGTPHRGSQDVAALGEVMRSVVSVLGMETSPINLHALGLKTSDLERAQEGFSRIWQKYDFQVKTFQEGLSFTRLGRKVVPDYSSLIGDHREHAETLQADHLEMCRFSGKNDPNYHKVAGELCSIYRSITPATKVDAFPSHRIRHRLRSLGDSSLKESAQSASADQVNDGCLGFLWFPAINNRLQNVESPAHRTCSWLFTHQVYEAWFNGTSRSSCYGLLWLKGKPGAGKSTLMKEAFSRAVIEQPKFGYTAVAFFFCANGDELEHTSLGLFRSLLYQLLPGSGPALRRFDQHCNRKMGPFKSQRKLAEAITWTETELRTLLQSALLNQTKRTLIFIDGLDECDESSIRGLAYFWRSITKVAHDLGHDLNVCLSSRHFPTISLGDCAEIVVEQHNGPDIATYVDQRLQICMSTRESHWDYLRGQILEKAAGVFLWAVLVVQDVLEKWDNGLELPYLIRRVRDVPEALENLFAKLLSHLDPTTRELTVRFFQWVILATKPLRLHEWHHIMAFVRRPLPSEKPPRASRLTIKDRGPDVHNSRPAFRSLTEWRQSVHFTESDEQLEKQIRGLSRGLVEIKKVSVSEPKEGEIDVVSMHAGAGSLNLEHGDTRIVQVIHESVRDFFLGSNGFSVLDSSLRHHPIGHGHLTIMATCLDYVHIAELDALVKARILAAGRRDRAKHLDKTSSGDAHSQHSTAGEQLRPTVKDSRNASVFDSLASNPALGIDIVEWLATDGRTPVRWSLPEELPCGSDTSASDESPARVLEDYPALLSYATSTMFIHAQMAEKDGIDQSPLVKRFEDEATWNRWLALREDIPNNTPMRSYAVQMGLRSWSQHYIRDGVLSPSASEQAEDGDSSSDWSGSVASFSSASSHAAFDNRRRLSRSRDKMAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBG6</accession>
    <name>A0A2T4CBG6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1352832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBG6"/>
    <dbReference type="SMR" id="A0A2T4CBG6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBG6"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015451965" evidence="8">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="153"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="409" mass="42398" checksum="9F8EBDE35B128494" modified="2018-07-18" version="1">MASLRRLALYLGALLPAVLAAPAVNHKLPQAVPNKFIVTLKDGASVDADSHLTWVEDLHRRSLGKRSTAGVEKTYNIDTWNAYAGEFDEETVEQIKANPDVASVEPDYIMWLSDIVEDKRALTTQTGAPWGLGTVSHRTSGSTSYIYDTSAGSGTFAYVVDSGINTAHQQFGGRASLGYNAAGGDHVDTLGHGTHVSGTIGGSTYGVAKQASLISVKVFQGNSASTSVILDGYNWAVNDIVSRNRASKSAINMSLGGPASSTWTTAINAAFNKGVLTIVAAGNGDALGNPQPVSSTSPANVPNAITVAAIDINWRTASFTNYGPGVDVFAPGVNILSSWIGSNTATNTISGTSMATPHVVGLALYLQALEGLSTPTAVTNRIKALATTGRVTGSLNGSPNTIIFNGNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBH6</accession>
    <name>A0A2T4CBH6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1400047</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBH6"/>
    <dbReference type="STRING" id="983965.A0A2T4CBH6"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02871">
        <property type="entry name" value="GH18_chitinase_D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015549586" description="chitinase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="39"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB78921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="343" mass="36219" checksum="4704E64ECC0B7851" modified="2018-07-18" version="1">MTRLLDASFVLLPAIASALFGTASAQNATCATKGKPAGKVLQGYWENWDGASNGVHPPFGWTPIENPQIIQNGYNVINAAFPVILPDGTALWEDGMDATVKVATPAEMCQAKAAGATILMSIGGATAAIDLSSSAVADKFISTIVPILKQYNFDGIDIDIETGLTGSGSVGTLSTSQTNLIRIIDGILAQMPSNFGLTMAPETAYVTGGSITYGSIWGSYLPIIKKYVDNGRLWWLNMQYYNGDMYGCSGDSYAAGTVAGFVAQTDCLNNGLVIQGTTFKVPYSMQVPGLPAQSGAGGGYMSPSLVAQAWDHYNGALKGLMTWSINWDGSKNWTFSDNLNGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBS2</accession>
    <name>A0A2T4CBS2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_225702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBS2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="130" mass="14428" checksum="0745199A6E4F5356" modified="2018-07-18" version="1">MTPQKPDRISMILCTSIGVGGCDRAAWFLSRDVESSLKSKLVQPQPEGQTPHRSFALSSISWLLKLSILTFARVRTSLLQSGCPMTAYHICASRTAQHTSRRCATWTHGFVCPPCPLELLRKTKKRATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCA2</accession>
    <name>A0A2T4CCA2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase 2C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1326834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCA2"/>
    <dbReference type="STRING" id="983965.A0A2T4CCA2"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="606" mass="66521" checksum="9249DF144D754CF8" modified="2018-07-18" version="1">MHRTAVRALRTSHRPSVRSQVRSPVLARGHNPSHHHHHHHNHRLLHQHAHPQRPPGAAHVPLRSSMYFRRLPVALASGLLLGYGAWQYNSDDSVSGAAVTHSFTTTRGAADAAPTRTVLVVGADELRQGTIVGEGPLYKASTEDGHRIVEMLTPDQATAKLRRQEQSFYVNRGQGVTRYDLVQLGSNDPIEDDHAEKIVEVPVRIPATDPEGEEVVTSSDWMFWGVFDGHSGWTTSATLRESLISYVARELNSTYKASSTDIPPPEAIDSAIKAGFTRLDDEIVHKSVEKVFKASSKAVAAELLQPALSGSCALLSFYDSRSELLRVACTGDSRAVLGRRSKSGKWVATALSEDQTGGNPSEVARMRMEHPGEEHVIRNGRVLGGLEPTRAFGDAVYKWSREVAGKLRENFFGRSPSPLLRTPPYVTAEPVVTTTKIEPENGDFVVLATDGLWEMLTNEEVVGLVGQWIETQKTGKPSSQFDKAWSKVFGSQSKPLPVEQGKEAAGFDGKTPIRVQQWGIDPDASDRFVVRDKNVATHLVRNALGGANDEQVCALLTLPSPFSRRYRDDLTVQVIFFGHGDKTSDKTGDVTVNLDATTDQDPRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCB6</accession>
    <name>A0A2T4CCB6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1326156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCB6"/>
    <dbReference type="STRING" id="983965.A0A2T4CCB6"/>
    <dbReference type="OrthoDB" id="4777826at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="23511" checksum="449AAC6DB98FBD82" modified="2018-07-18" version="1">MPPKAASSSDAGAASKPTGTWDNVDFLRELLVAFYQVGNNSFNPQVNTAIVEYLAAQGYETSWSAIRDGLLVYRGCPSTSDAAPPRKPTRGWDATSHEALLLCIIDEVKGGKAFMTEVTKKMQDRGYTYSYDAINQHVQKLRKNRDTAGIVAASESGVSTPRKSATPTPRKRRSAKKEVDDADDAMNLKLEQHEDEEMGSPCERPRKRGKSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCL5</accession>
    <name>A0A2T4CCL5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1436632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCL5"/>
    <dbReference type="STRING" id="983965.A0A2T4CCL5"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="717" mass="79873" checksum="862FF9D00EEE49C8" modified="2018-07-18" version="1">MPAPAAGPGSTTSASGSDDAKDAASASASGSAPPPAPADIPVRTKESFDRLMVERYTMRDAIAASALSQQLNQTMKSSHEMREMINEYRSVRTQYQQWFPPSRLYGEGYNGFANGYTENHGPSRVVYPSQKPRPGHRTTPPLKYSRKDMLKQAEQHEDLVPLRLDVEWDRIKLRDTFTWNLHERLLAVELFAAQLVEDMGLKPPASQPVYEQVVQQMREQLNDFYPFAYSEEDALDPELPYSAYKNDEMRILVKLNITIGQHTLVDQFEWEINNPNNSPEEFAARMTRDLSLSGEFTTAIAHCIREQSQLFTKSLYSIGHPFDGRPVEDSDLVSAFLQTPLPTVFRPQQQAKEYAPYLYEMSEADLERNETVFSRDQRRQKRSINRRGGPQLPDLKERQRTIRTLIVSSVLPGAAATIEESRLFKKVAGPPRKRTARDGEISESEESEDSAPESPAPSNMPAGTTRTRNVRGAATAATIRMANLGRSETPDTGGHHHETRTSRRGRDDEPEERPELVVTLKVSREKLKRLMRGDYRDLAAASVPPDTPSSASNIRTPTFSALQKTKSATPVPTPTQPGSASQPTGAVPAGQIGRLPAPPLIPGQSPPPAPPPPEWLVQSLKELEEKYPNGDRFEAIMKYSHLDPVTELPVQTQPMPEGVKYAWLPRIRCLDCTTKLYTPGPDMTAQKFEAHLKFSGHREKVRQRLAAQGGSGSAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCQ7</accession>
    <name>A0A2T4CCQ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1419735</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4CCQ7"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015691126" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="529" mass="59985" checksum="26FA0A32BB373275" modified="2018-07-18" version="1">MWRRTYLLLVLVRLWFALSPSYLHPDENFQGPEVIAGQIFSYPVRHTWEFTSEDPIRSVFPLWPVYGLPMLLLQWLWVGNGQDGQVPPIAVFWTLRFFMFLLSFVLEYWALQEQITSTLHRPIAVLLVASSYVTWTFQTHTFSNSIETLAVLWSLVLIGRITSPHSSILSSVVLGMVVVFGIFNRITFPAFLLIPGLWLVPYYWKKPLSLAALWLAALVTACTAIAVDTAFYKPGTVTWSDLIAHPVITPLNNLVYNSSPENLALHGLHPWYQHLVANLPQLIGPAVALVFIRPHVSLRLWSAISGIAALSFVQHQEARFLLPAVPLILSSVQLPRNLTLCRIWVAIWVVFNLFLGLLMGVYHQGGIVPGQVFMSQQPDATTAVWWKTYSPPIWLLNGKNEVLTTRDVMGMKGEALLDLLTELATCDTPADRRNMNYLKENNGTYLIAPASATWLDPYLPNKGLEGLRFREVWRYRKHINLDDLDFGDDGVWNTLSRVIGRRGLVAWRVTKSCGRSWEFPNIDGQPNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCV2</accession>
    <name>A0A2T4CCV2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1398686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCV2"/>
    <dbReference type="STRING" id="983965.A0A2T4CCV2"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="252" mass="27387" checksum="75685BF4B3913FC9" modified="2018-07-18" version="1">MRPNGASALLSAFQGLRISACTPLRQLRAPAQRPAAILGAAQLLQNGRAFSTSPAMMGTWLEPSLNRKKKMAKGRPRVATGGSTKGTTVIWGDYGLRMVDHHRRISAKSLKMAEDTIKVRLRGEKYRLYKRKCCNVGVYVSGNEMRMGKGKGSFDHWATRMAVSQVLFEIKGRIHEQIVRDAFRLAGNKLPGQWEFVKKGDPPVVGITKLDGVSLEDLKRPRKHLAPQELLEAASTKAGAAAGGPSAPSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD85</accession>
    <name>A0A2T4CD85_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear architecture-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_239495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD85"/>
    <dbReference type="STRING" id="983965.A0A2T4CD85"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="8">
        <location>
            <begin position="174"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB79506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="578" mass="61148" checksum="D47C880560963393" modified="2018-07-18" version="1">MSAILSADDLNDFISPGVACIKPIETLPAAPPQQPSAAADENQVILDGQQPSTSPSAASSPAQISLTDCLACSGCVTSAEAILVSLQSHTEVISTLDAAPALRVVGPDAGGNFAVEGLENEDAKLFVASVSAQTRANLAAACGPGVSESQAGYMLENLLRGPEGLAKAGKWNNSFEWVVDINVARDATLALGAAEVLSSPTPGVAKPSQPILASSCPGWVCYAEKTHPYVLPHLSKVKSPQALMGTILKTTLSKKLGIPPSRIWHVAVMPCFDKKLEASREELTDEVWARSGLPGKGIRDVDCVITSKEVLMLAESRGLDFFNFSRTTSSVPPSIPFPDEKIHELLFPNNGSENPPRVAGSSGGLLHHILQTKAAQTPGSEIQVVRGRNADVVEYFVTVNGEPVFKAARYYGFRNIQNLVRRLKPARPSRMPGGKPFGSARRPAGKAASHDYGFVEVMACPGGCTNGGGQIKVDDPVILERKNISGKPGPQEQKDWLAEIDEAYFSGEDSLVEHNAEKVVGGISHAYIDDTLAYWSGMTGIGLDRLAFTSFREVISDVGKNTATERAAQLAGKAGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDD9</accession>
    <name>A0A2T4CDD9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1389507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDD9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015418242" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14705" checksum="89F4ED1421D834CD" modified="2018-07-18" version="1">MVRTTTLTRSPLLLLLLLLLLLPLSPSCGLPLSGAALLSRQQAVSSVWTASEKLLWFCGNSPTAANDQDPKAPRVFVRLAQSSKSSTLAPSGPKLLVNSQPRRCVFLGRLASIRTEGERAPAWIAIRPQSYPLAVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDX6</accession>
    <name>A0A2T4CDX6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1318571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDX6"/>
    <dbReference type="STRING" id="983965.A0A2T4CDX6"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="21979" checksum="8A94F1B75874942C" modified="2018-07-18" version="1" fragment="single">AASSKANYKTYEAQARMVRAIVAAHPEVKWNYKEIVACYGSDMSEHALNHRFRRLRAQAVIIREGRKEGFDMKDIIPDGDLPVTQEAVEKNNIAKYFGESTPDGIGFQFRGIKKDAETLRKVESEGGDVANCLNLGSARGSGSVMSTPSKPTAFRSAGSRSGTGTGRKRARKTDLIKRSESDEEDDDDVLDGHNWSEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE49</accession>
    <name>A0A2T4CE49_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1435637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE49"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53684" checksum="9253235360BB9DFD" modified="2018-07-18" version="1">MAAEKDEVAIVEAQPQHQHLSTWRYNSPFVQTIIVGFVLFCNPGTYLAITGLGAGGKQPQLIGIVNKANVILYCLFGASGILGGSIINKIGPRWALMIGATGYPMYAGSLWWIDKGEGSWFVLFGGAWLGLSAGLLWSTQGYITTCYPTEADKGKYIATSWVLNAMGSVVGAAIVLGVTINNTTVSGVPSSVYIIFICLECVGLLLAGLLLDPSKLRRNDGRPIASFAPLPWYQELQALGLTLLEPKMALITLSIFSSEMYLSLTGAFNAWYFNARTRSLANFCYWILQVLGALAIAWICDASILGSRRRRAFAAGTFVAVVIGGTWIAMISFLSVNNIDRSETPRAIDWTETTKFAGPFVIYILFGACYPIFQNFHHWTYSTFSNEPHVLGRYSGYFKGFQAFGTATAFGIDTHGVQFIREAGAYFSMMMLGLILTMISIYFYTTETKYGQEEGVVIPEAFEDVVEEHTEEIHNKSLDQSETTGSQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE62</accession>
    <name>A0A2T4CE62_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1326606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE62"/>
    <dbReference type="STRING" id="983965.A0A2T4CE62"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="127" mass="14084" checksum="610665A267E78E6F" modified="2018-07-18" version="1">MKVLSLNFLTCAVKACKSSSSSYPLHPRDAELVQDEIEVNPEMLVNVLPRLDWAALRTTSSELGFPPLPEQPPTQEELQADDKLVRDLHHLLLETQIAEGKLVCANCGHEYAVKEGIANFLLPSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE74</accession>
    <name>A0A2T4CE74_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1399134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE74"/>
    <dbReference type="STRING" id="983965.A0A2T4CE74"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="460" mass="49928" checksum="4CEBEA057F9EEEEE" modified="2018-07-18" version="1">MTAKSRAFLPTASSPDYRNLDAASGHAQQPPRRPNLKKLAVGASLALATIGLLYKPAFSHYQRIYQHSCSKALTVEERAHKILSTTPLIDGHVDFPLVLRGPYGNHLQGDGFTGPFENGTLKGHVDLARLRAGRAGGAFWSVYAPCPVNGTDFSDGNYADSLQFTLQEIDIMKRLFAAYPDDFAHDVDSSDAIDAFRAGKLISPLGIEGLHQIANQAGNLRMFRDLGVRYATLTHNCHNKFADAALLESPFRKATPVWGGISPLGRQLVHEMNRIGMIVDLAHVSEDTMVDALGGREDWEGSKAPVIFSHSSAYGICPHPRNVKDKVLQLVKETNSLVMVNIAPQFISCIDNGNDNGVPDEDPDNATLERVVDHIVYIGSRIGYDHVGIGTDFDGIGSVPNGLEDVSKYPDLIAELLRRGVSDADAAKVVGENLIRVWKAVDAVSAEMKANGAPIMEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE99</accession>
    <name>A0A2T4CE99_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1105414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE99"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="254" mass="28209" checksum="0FC71473A8349DBE" modified="2018-07-18" version="1">MMKVLCLHGAFGSASNFKVQLGIFTDAVKQPDIEFKWINGFTKATPPSGFDDYFGAPPLYRFIDVDGMSELEQMVVKIRDIPQGDSPEETMRKLVADKEQFTTPAVTMALSQLLQLLDDDPEIDAILGYSEGATAAGSLILEEQRLFRDQGRPRHIKCAIFFAGWPPVRIADGRVKTLLADEHDEMIDIPTCHIVGCNDPYIDGAVALYGMCDEDVATLFDHGKGHTVPRDETTVRELAKTIEKTFEQAALFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEB2</accession>
    <name>A0A2T4CEB2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEB2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="97" mass="10603" checksum="59F0A8B249FB6BFE" modified="2018-07-18" version="1">MHHYSPGAAGPRPSRPLEPQSRPSPLLPVTSCPFPLTWSPILLIRPNPPAPQSDPCLISPSTLQKPNPSFFLLKTDAKLSFARVTVQLLLCGTTHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CED2</accession>
    <name>A0A2T4CED2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSCRP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1460034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CED2"/>
    <dbReference type="OrthoDB" id="4509278at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015631107" description="SSCRP protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15733" checksum="CF927BB730906CF7" modified="2018-07-18" version="1">MKFFTTISAIGLFASACLAQDAPVQTAHVTLRSEGDDHSYPLTVPADGKPVLTHSTLPIALIDAPDFNVLQACVIETPGDKNLSSKIAADGVTQQVVIDPPQAVTSISCQGTCVETYGACFDTNGQYVGACCNGLCIASRCRPWNIGQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEP9</accession>
    <name>A0A2T4CEP9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_16361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEP9"/>
    <dbReference type="STRING" id="983965.A0A2T4CEP9"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="400" mass="43108" checksum="CCB580BBD3C6EAC4" modified="2018-07-18" version="1">MLVSLTVGKVDAGVTVLLTPDKRLIEFPSILLPPNISSGSIVDITVGRNVSKEAAAEEEFRALQDRIFQSFGASEPAAPVLRCRNATQTSVVLEWDPIELATADLISLSLYRNGQKAGNIPRPLEMHSTKISGLAVDTEYSFHLVLRTSAGTRASERVVVRTHKMTDLSGITITTGILPAATRENLTRAVERIGAKIVDGVRIDTTHFVTTEGRGTAWEKAVENNIPVVRPEWVTACEQNGRILGVTKFYLDVMRPGPPSDDQLPPPPAKDVPPKDTPPRASPPAQDASHDKARDSKASPANGNKNHEEEGEASTKADADSSSSEKEEEGEGESSEQKAKSGQQAEQKVRLEDVQEQKVALRPVESQTALVEQVEDSDGGEDDSKPASPPDGASFQEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEY8</accession>
    <name>A0A2T4CEY8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1324805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endohydrolysis of (1-&gt;3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran.</text>
            <dbReference type="EC" id="3.2.1.59"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 71 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.59" evidence="5"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEY8"/>
    <dbReference type="STRING" id="983965.A0A2T4CEY8"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904541">
        <property type="term" value="P:fungal-type cell wall disassembly involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000268">
        <property type="entry name" value="Glucan endo-1,3-alpha-glucosidase agn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015506017" description="glucan endo-1,3-alpha-glucosidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00052604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="427" mass="46668" checksum="D91817696D4CB9D4" modified="2018-07-18" version="1">MSTRLAITLAAFMVILSDAVGFVVAQGSRPVFAHFMVGIVEKFTIQDWINEIQQAQAIGIDGFALNCAPPWVDSYTPKQLDNAYTAAQQLNFKMFISFDFAYWSNGDTGNITSLVGQYAAHPAQAMFNGGALVSTFVGDSFNWNAVKSALGSQKVTVIPNMQDPASLGSVSNQLGIDGAFSWYAWPTDGGNSVIKGPMTTVWDMRYIEGLGGRPYMAPVSPWFSTHFNTKNWVFICEEQPVRRWQQILDMKPAIVEIITWNDFGESHYISGSEPNHSDDGSSQWANGFPHDGWRDIYKPYIAAYKAGASSPTVQADELVYWYRPTPHGAQCSSDPLGIPRGAELMDDLVFVSTLLTQPAQLTVTSGNVAPVTVDADVGIHVFNFTMGVGKQSFSLSRGGRQILGGQSAKDISSSCQTYNFNAYVGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF55</accession>
    <name>A0A2T4CF55_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1397519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF55"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="82" mass="9250" checksum="79F69A285C0BBEA9" modified="2018-07-18" version="1">MRRRLLDGGNQALLYTFLALLVSRQTLADSLLSILLPCLLFHLVGWFADIVSRLNVGRGLIAISVPLYNERDRDTYYAAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFB7</accession>
    <name>A0A2T4CFB7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1120276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFB7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="169" mass="18349" checksum="E27BC631C1B62AE7" modified="2018-07-18" version="1">MLVPIRLDSAHTSCPTETPDHFPSVQSSHSALPSHHFPGLQSSDQACVVGCPSLSVCRRCFQSSTRNIALRLRSFALPSSLSQSTIVFPGSKLGLRCSAFGSLDSNTTSTDSLPSPNQLNPRSTSQSPCRTLCYHSSTIALGLAYAGLRWSLSRSLSRRTKYIQTHLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFF0</accession>
    <name>A0A2T4CFF0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1418906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFF0"/>
    <dbReference type="STRING" id="983965.A0A2T4CFF0"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="894" mass="102330" checksum="5DE3BC882D96EBA8" modified="2018-07-18" version="1">MGLLDRVEAIFGGENDAERHSHSHSGYQCDEFHPEEHVANRYQSFVPPSSGNIKWFVDGCSYFWAVSEALQRAEESIYILDWWLSPELYLRRPPSRNEQYRLDVMLQAAAERGVKVHIIVYKEVEAALTLDSAHTKHALEKLHPNISVFRHPDHAPAGYDIASDIGTSFKNLTNFDLATVSKDTLKAIYGAVDDVVLYWAHHEKLLVVDRNLVFMGGLDMCFGRWDTNSHPIADAHPGNVDNTIFPGQDYNNARIFDFADVGNWEQNQLDRTKSSRMGWSDVALSMNGPIVSDLVTHFVDRWNFMFDAKYNAKDPGKYERLSLPGGPRSSRRRYEQEGYEQEDYDRREEGQREYEQERGGGGGMFSRFTEHLTEEMGHLGLSERHRSHRDERYDDEQYDERDGDQRYGGERSYGRRSEREATRIQLTRSCCPWSSGHPTEHSIANAYVGAITNAKHFVYIENQFFITATSDEQRPVSNKIGAAIVDRIVRAYEEGQPFKVWVVMPSVPAFAGDLKSKEALGTRAIMEFQYNSISRGGHSIIQKLVAAGIENPREYIGFYNLRNYDRINTSGTMQQAEYRSGVSYEDARRYHDDYVNEERYGGDDGDSYNYDRYQRQAQYVQDDTLDTVSAAYMKDGPNIVDIPWDGAPEDEFNAFVSEQLYIHSKLLIADDRVVICGSANLNDRSQLGTHDSEIAVVIEGPRNLDSYMNGEQYAASEFAASLRRQIFRKHLGLLPDQRWDRPDQNWLPVTDAPNDYDWGSSADRLVEDPLSPDFLNLWEDTASINTEVFSRAFHPVPDDHVRTWDDYEEFFSKHFIIPSAKGDDKKSDDGNDEGKVPYGHAVREEFPGGVQELKEWLSRIRGTLINMPLQFLIEVDDIAKEGLTLNGLTDELYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG23</accession>
    <name>A0A2T4CG23_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1128311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG23"/>
    <dbReference type="OrthoDB" id="10656849at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="124" mass="13682" checksum="0F2696BD90B316DA" modified="2018-07-18" version="1">MDMVVSSSCWFLCLFACFFFLFSLCFWSLSKSREAPVRSSLWEMDVWSVQLHTATGGGPDARERFSLGETGGEKKAAGGDLPVEARRDTQRAPAMEGPPRTWSYVLYLPPDAPPDVPSGCKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGH7</accession>
    <name>A0A2T4CGH7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1388874</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="5"/>
    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGH7"/>
    <dbReference type="STRING" id="983965.A0A2T4CGH7"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="21">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PTB80644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="901" mass="96838" checksum="4D7EDABF4536121E" modified="2018-07-18" version="1">MADQLRYDGQVVVITGAGGGLGKAYATFFGSRGASVVVNDLGGSFKGEGNSTKAADVVVEEIKKAGGKAVANYDSVENGERIIETAIKAFGRVDVLINNAGILRDVAFKNIKDEDWDLVIKVHVTGAYKCTRAAWPHFRKQKYGRVINTASAAGLFGSFGQTNYSAAKLAMVGFTETLAKEGAKYNILSNVIAPIAASRMTETVMPPDVLKALGPEWIVPLVAVLVHSNNTTENGSIFEAGAGHMAKLRWERSSGLLLKADDSYTPGAILKQWNKVVDFSNPQYPSGPNDFMTLLEESMKMGPSEQGEKLDFTGRVALITGAGAGIGHAYALAFAKYGASVVVNDLVNPDTTVEEIKKLGGKAVGVKASAEDGDAVVKAAIDAFGRVDIVVNNAGILRDKAFTNMDDNLWHPVMNVHLRGTYKVTKAAWPYFLKQKYGRVINTTSTSGIYGNFGQANYAAAKCGILGFSRALALEGFKYGIYVNTIAPNAGTAMTATIMPKEMVDAFKPDYIAPLVLALSSDKCPNPTGGLYEVGSGWCGKTRWQRTGGHGFPVNKPLVPEEVVKHWDEIVNFDDGRADHPEKAQDGLEKIMKNIENKAQGDSSSSSSSAAAPAGNEYLAAIEEALKKEGEPTEYSFTERDVILYNIGVGAKRKELKYVFEGAEDFQPLPTFGVIPPFSAETPFDYDAIVPNFSPMMLLHGEQYLEILKFPLPTSGRLVSRAKLLEVVDKGSAAIVKTGITTVNAENNEPVFYNEMTVFLRGSGGFGGLKRGADRGPATATNEPPKRAPDVVVETATGEDQAAIYRLSGDYNPLHIDPGFAKMGGFKAPILHGLCTFGIAGKAVFDRFGRFRNVKVRFAGPVIPGETVVTEMWREGKRVVFQCRVRETGKLCIGGAAAELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGZ6</accession>
    <name>A0A2T4CGZ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1395977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGZ6"/>
    <dbReference type="STRING" id="983965.A0A2T4CGZ6"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="353"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="416" mass="45056" checksum="A769911396B6A1DF" modified="2018-07-18" version="1">MKKFGFGKKSDDGEDANRNALFGSRKKNSPAPSENPYANQGASDPYAEQTKYANMGSHQPGQGGPNNGARPPPGSGYSSYQGGQNAGPPQAASSGYGSDRYGSGGGYGSNRYDSGPAQNAPAGARGPGGYGGFGRDAPDTNRDALFGGAQQRLEQKQQTAPASGGYSAASGVSGGSYGGYGEQRELTEEEQEEADYQAILAEKRQLQQESVSSVQRSVQMARQANEVGRATLARLGAQGERLHNTEKNLDLAANQNKIAQDRAAELKTLNGSMFAVHVGNPFTSKQRQQRADEEILARHRAEREQRETTRRDGYAATQRMEQNMRQLNTGIGRQQGRKKDYGKFNLDDEEGADELEDQIDEGLTELEGQVKMMNMVGRAIGSEVDAQNKQIDRIMNKSDAVDDATRMNRERLARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHM4</accession>
    <name>A0A2T4CHM4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_75918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHM4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="350" mass="39370" checksum="5FF23FAC9E271410" modified="2018-07-18" version="1">MHGVCLFTSLWHFLYIWVGVFVYTSGFHGGRVYTILGSWRAGPWNTCHTLAEAASRTEAFYADYDTRVLHALMLIFGPLFIFDTPHAACFLLRVLAFGLASLELGSLLFFPSSKMEEMDEYGRIAADLICGLSLVPSLWDIYRGAKWTRWSESLYWRSPTELFCAASDGLICCHARRTNSCLSAACGKLLYPRLTTKPYGCPGLGWLTPFASLFFGDGISSCTYTFSPFLVSFGNQENHNYEALLESAWLFNTTRRGTFNLPWCPKAALQARSATILHFSCYGIFSYFSISFYSLHSLARCYTSGEGTGWLYRFGNGIRTDREVLAVGWYGRGKKLYTTRKATTKKRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHW5</accession>
    <name>A0A2T4CHW5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1321327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHW5"/>
    <dbReference type="STRING" id="983965.A0A2T4CHW5"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="319" mass="34220" checksum="178048C9B7669AA6" modified="2018-07-18" version="1">MPSQKPVALVVGASRGIGRQVAIDLAKNGYAGKLFPNAVVVAAKSITDPSKLPSKTPDPKSPASTVTTVAREIASAGGEATPVQVDVRSEESVNALVAKTIAKYNRLDVVVYNSGAIWWASVADTPLKRFQLMQRVNPEGLYAVVQAALPHLRKAPQGGRLVVVSPPIYSRFFRGKAAYAVGKVGMSVLTKGLAMDFEREGRTDMAITSIWPAVAIESAATEQFTKLNPSEAADLRKPTIFSDAILAILRAPAARVNGQLLLDEDFLRDECGVADFAKYSVVPGSKPRRIMPRRLPDLTVDEQDDEGKRVDSAAARSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI21</accession>
    <name>A0A2T4CI21_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1396352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI21"/>
    <dbReference type="STRING" id="983965.A0A2T4CI21"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000007">
        <property type="entry name" value="Mitochondrial ribosomal protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25869" checksum="15354863EB14CFBC" modified="2018-07-18" version="1">MNAASVVRQPVGCLKAALRRTRFQRSWQRCMATEATPTTTTTTTSNPSMVRTAFSQRQHMEQKKVAKFQIWPQVPSPRTTNPDPMPALTRQEIARLDPTGARTRLFSREHADSAKVGDVLMVTSKGGEPFSGVFIQLRRRGVDTAILLRGQMMKVGVEMWFKIYSPTVTGIDIIWRRPKRARRARLTYMRQPKHDMGSVDNLVAAWKKERYALRSKAKQAGGRRITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIA7</accession>
    <name>A0A2T4CIA7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIA7"/>
    <dbReference type="STRING" id="983965.A0A2T4CIA7"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015722112" evidence="1">
        <location>
            <begin position="18"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="230" mass="25281" checksum="7D39DED7A2E59443" modified="2018-07-18" version="1">MLLQTAICLLAALPASASSLKWHWRNNPGIKPISPISRTVTIQVPPDTDIWRPSLSKHNFTAPYLYTVLPASRFQSVRVTVTAPWKTLYDQGGLVVTFPDERNANRTRFIKAGIEFNDGAPALGVVATDILSDWSLSPITAQQKEEKNAKATTLVERDGTDAWVYVLEDEGGTRRALRQVTWAFNEDDAQGLAREVEVGIYGAKPTEEAGEGHERDGIAVTFSGFALEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIF8</accession>
    <name>A0A2T4CIF8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1321517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIF8"/>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="236"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="355"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="496" mass="56978" checksum="48916122B8CF6033" modified="2018-07-18" version="1">MELSSPIEDAALVDAHLLKGCCLEADRSDSVSLRLEGLFIALPEANRRHLEPLIDEIRTSSLLLRELADLSQVHQDRVPLVLDPLNTVLPCMSRSLRDITTHYENRKLTKVNRWRTMFHEMTNEVGGLQLPQRFVVYNQYLSAIRDLLSRSPNFDLNMMEAFRLQIMNLREARGIPPPPIRAGPLVRYGALPPADTDPSIHWSEQIFSLPLPSRSPFKSQLPSESFGPHRPWGHLSIPNNSKVLFRRPIDGDKISLIAYSDGRDGSPHLLLRTFYMGGPWFSLRGVHELCIQRDNEAIHFTRWSRSENCSKLWATLRFQTWEELILMYCTFLALKSRNTLTVQLGTKEYALKGEKKLFQACILDDGFKHSLIVYEDKCTGGRRIHVAVWEGELRQCPVWTAFVTHQSASPTWLKRVSRKRIRLADLQLYVFCQQYRQQSQRKGSGGSFELQFYSEEAAQSFKDLFTPIPTKSNMSRPITPRPITPRIVSRPTTPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJM2</accession>
    <name>A0A2T4CJM2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1322604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJM2"/>
    <dbReference type="STRING" id="983965.A0A2T4CJM2"/>
    <dbReference type="OrthoDB" id="5093543at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="773"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128874" checksum="7A8F65DF923A1836" modified="2018-07-18" version="1">MPHLASPMQSEGSVHESNQIFYHPTKPPVVGIARMADLEDDEVPEDSTYIDSNAENDGDVDGLSDYTDGVEDHDDGSGGEESGEMDGRAIESDEERMKREERQKAEQLAKEKELLLGDVETEIRQAAKKERQLDETEFLAKYGDVLDHIMQESSSKKNVLHMLAIHPFEAPNQFPRWIIDHIHRNAINDARGKTRNSLAKLLVDKAHTTPSLALATATRWKNEPFIRAILSIVMQDGDESLGDSLRKNLRERIDAGNETPRNCIHCDGKGYTPLHLAVEYPKCLERLEVIKALLRYGEKALDQRCKERLSVYRHYQKTMAEHRKEESRKVSEPSKTNAPLGRIQRELKQVKEKQEAPRIGKEDRREKNKSNNAVRSPIGTPGRGRVRTRYGFPADMEFQNPAGEGEAMKSTKQASTGPKEVSTASRTPLTVSKQRPSTRKPANGKQSIAPSKPPRDKEKEKQVEDEIDDELKLQYFRSTWKLPNPDRDVRSANEPFSLTMLQGPPSIDQHVFTTVYGNKDYDHILHHVAVRRVVLKRTKNKEAGRTDMEIIFKLLKDKGVRHIVKVIVFDLEVPSHSDESIERCLSWFESIEILDWRKVDLCPETIAEACPKVVELHLWWSGNNAILVAWSAPGGLAKLPRLKKVHLHQTQCIESPERDKMNLQRFKERLQTDRIAQRPERDSPAGQRKTSFSGQRLPVTVLDMWPDITVNDSDTSNAAYNSRSLVAHGPQLNQRAARSRRRHEWLDIMDKFAAGIDLIDMERTHPPDILAEDVTVALIDDGVEITDRSLTNRIYNGWTCDTGYQGNGLEGILRPYTNSETQHGTFMASTICRICPRAKIFVFRLDVVSTPGDRAHFTAKSAADALELAIDPSRKFDVISMSWTIAKNQSNAKDIERLDNALKQATAQNRVLLFCASPDSGEMTKAHAETFFPFGCDGGSGLFKIAAATADGVRISMAGSRFDYSLPGHEVDSSSQGAGEGARELLQRNQHCSEVDHGGLKTGSSIATALGAGLAALIIYCVRLGAAYIYRVNPCTGTAANSDIHNVVLGRDSLESIKQPKKIRDVFNSMMSKSSSSDRYIEVYDMFGSLADELEMLGQEIEELKDRIRIEIQKGTAEANVAEKELRRKNDLRMLSIVKLAWRFVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJP7</accession>
    <name>A0A2T4CJP7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1459869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJP7"/>
    <dbReference type="STRING" id="983965.A0A2T4CJP7"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="193" mass="21634" checksum="2C85995A0F93B320" modified="2018-07-18" version="1">MPTSLSLPFDLPFRLDLDSRSLLVLTASLVAAVPAIYMCTAGAVRNRFPELLEKRVCLLIAHPDDEAMFFAPTVLALARPETGNHVKILCLSSGNSEGLGEVRKKELVQSGLALGLRDESDVFVVDNPQDPEHPERLVYTNNLFGSEPKLGTAWQAMTTAHKSQMVWFRYLWLGFSRYMLVNDLRLEKVDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJR7</accession>
    <name>A0A2T4CJR7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1023828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJR7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="157" mass="16872" checksum="7D9480C8CE37078F" modified="2018-07-18" version="1">MMVGAGEVSSRLHGGSRRTEKKEKDTLDGMRAIGTRSSPHFLHLVFIPRLRLLPCVPFCRVTAGIRILGVFLRDAAGLQCRFLHGRAGLSLAQQALQRARGSRAGPAGGRGARHRVNRDVAVPGPCSLGQGGQGKGCSLFHRHADVEMAFRIDGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJU0</accession>
    <name>A0A2T4CJU0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1347027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJU0"/>
    <dbReference type="STRING" id="983965.A0A2T4CJU0"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="115"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="11">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="578" mass="64158" checksum="821CF230C634DF5E" modified="2018-07-18" version="1">MASTQSMRALARAGQLAPNGVASRAFSAATKAAMLRSAARPSVAMKLTNTGRIAFRRAYADEAPKPKPGKLRRTFRWAWRLTYLSALGLVGYTAYNIYEDRHPDEQYEPDPSKKTLVILGTGWGSVALLKKLDTSNYNVVVVSPRNYFLFTPLLPSCTTGTIEHRSIMEPVRAILRGKKAAAKFFEAEATSIDPERKVVRIADNSEIKGATSETEIPYDMLVVGVGAENATFGIPGVREHSCFLKEINDAQQIRKKIMDCVETAAFKGQTPEEIDRLMHMVVVGGGPTGVEFAGELQDFFEEDIKKLVPDISPHFKVTLIEALPNVLPMFSKTLIDYTENTLREEKIDIKTKTMVKKVTDKTVEAEVSRPDGSKERVEIPYGLLVWATGNAVRPIVKDLASKIPAQKDSRRGLAVNEYLVVQGTRDIWAIGDCAVAGYAPTAQVASQEGSFLGKLFNNMAKTESYEQRIQELSSKMNIETGNSAEAAQEIELLERQLKKIRDVKPFRYSHQGSLAYIGSEKAVADVSWWNGNLATGGSLTYLFWRSAYLSMCFSTRNRVLVLLDWLKSKAFGRDVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPQ7</accession>
    <name>A0A2T4BPQ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1344583</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BPQ7"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="396"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="834" mass="90813" checksum="8C903A8C7E60C1EB" modified="2018-07-18" version="1">MADIDVEAVLKKLTLAEKVDLLAGIDFWHTKALSKHGVPSLRFTDGPNGVRGTKFFNGVPAACFPCGTALGSTFNQALLEEAGKMMGKEAIAKSAHVILGPTINMQRSPLGGRGFESIGEDPFLAGLGAAALIRGIQSTGVQATIKHFLCNDQEDKRMMVQSIVTERALREIYALPFQLAVRDSQPGAFMTAYNGINGVSCSENPKYLDGMLRKEWGWDGLIMSDWYGTYSTTEAVVAGLNLEMPGPPRFRGEVLKFNVSNGKPFIHVVDQRAREVLQFVKKCAASGVTENGPETTVNDTPETAALLRKIGNEGIVLLKNDNNVLPLSKSKKTLIVGPNAKQATYHGGGSAALRAYYAVTPFDGLSKQLETPPSYTVGAYTHRFLPILGEQCVTPDGAPGMRWRVFNEPPGTPNRQHIDELFFTKTEMHLVDYYHPQAADTWYADMEGTYTADEDCTYELGLVVCGTAKAYVDDKLVVDNATKQVPGDAFFGSATREETGRVHLAKGKTYTFKIEFGSAPTYTLKGDTITPGHGSLRVGGCKVIDAQAEIRKSVALAKEHDQVVICAGLNADWETEGADRASMKLPGALDQLIAEVAAANPNTVVVMQTGTPEEMPWLDATPAVVQAWYGGNETGNCIADVVFGAHNPSGKLSLSFPKRLQDNPAFLNFRTEAGRTLYGEDVYVGYRYYEFADRDVNFPFGHGLSYTTFAFSNLSVSHGDGKLSASLSVRNTGSVPGAQVAQLYVKPLQAAKINRPVKELKGFAKVHLQPGETKTVTIEEQEKYVAAYFDEERDQWCVERGEYEVIVSDSSAVREGATLRGKFAVDETYWWSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ06</accession>
    <name>A0A2T4BQ06_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_62354</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ06"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ06"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB71384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="626" mass="70151" checksum="A536634980CACFAC" modified="2018-07-18" version="1">MECLRNKFTGGLLLDGGRYQTISPLNHGSFGMVFMAQDLVSNQVVAIKCLTKKSAASDTGLELAVDERSEEYALHSSLGSHPNIVNLLDTFETDAHVFLVMEFCSQGDLYEAIRNGHGPLETEHVRQFMLELVDAVAYIHSKGVYHRDIKPENIFLTQDGAMKLGDFGLATTDKWSYETTVGSDRYMAPEQFDSAGAGYSPAEADIWAIGICLLNILFSRNPFTTPTEADPLFLDFSRDKQSLFDVFPSMSQDTYEVIVQCMNLDPRKRSLEGARDALLRVVSFTTEDESLDDFCGAENPTLASAHREPLRTPSIQTPHVDGGAFPWTKALNETPARRQLSAIPDDESYSEDLFSKSGETTDWCSAYVQTPSSSIMDTRAIEARMRNFQISRPPQPKVSPTAGSLPIAMGKPFPSMASVFGIQKDTVSKSWSDMWDEDEEEEQQQQEQQRVNALKELNSRTWSHESTHDQSAQKTEPVATAHVIKGDVDDDLVADGFFFHEASPPTAHHAFTITPRYSPPSKRGNGGNIDKWAALGERRRGQNTIGVEPEKSPGWKQRRHLGLGYSYNSNAGHFHHQFNNHNNKSYEAGGYNKDRLKENSWTKAKDWNWRKDRRTDLGDVEWVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ53</accession>
    <name>A0A2T4BQ53_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-dehydroquinate synthase</fullName>
                <shortName evidence="23">DHQS</shortName>
                <ecNumber evidence="23">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="23">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="23">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="23">EPSP synthase</shortName>
                <shortName evidence="23">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">Shikimate kinase</fullName>
                <shortName evidence="23">SK</shortName>
                <ecNumber evidence="23">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="23">3-dehydroquinase</shortName>
                <ecNumber evidence="23">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="23">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="23">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="31" type="ORF">M440DRAFT_1386749</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22 23 24">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 23 24">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 24">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23 24">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 23 24">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23 24">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 23 24">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23 24">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="24">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="23"/>
    <dbReference type="EC" id="2.5.1.19" evidence="23"/>
    <dbReference type="EC" id="2.7.1.71" evidence="23"/>
    <dbReference type="EC" id="4.2.1.10" evidence="23"/>
    <dbReference type="EC" id="1.1.1.25" evidence="23"/>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BQ53"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000015">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="1571" mass="169808" checksum="C9FE9356EF69C1BE" modified="2018-07-18" version="1">MADAAAAPPPQTISILGEPNIVVDHALWPNYIVQDLTQNLASSTYVLITDTNLFDTYVPAFQQRFEASKPNPAARLLTYAIPPGEASKSRETKAEIEDWLLSHQCTRDTVIIAVGGGVIGDMIGYVAATFMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLVGAFWQPRRIFIDLAFLETLPVREFINGMAEVVKTAAIWDEKEFTVLEESAATILSSVRSKGRNRLQPIKDVLRRIVTGSARVKAEVVSSDEREGGLRNLLNFGHSIGHAIEALLTPQLLHGEAVAIGMVKEAELARFLGVLRPEAVARLEKCIASYGLPTSLKDKRVISLTAGKKCPVDVLLKKMAVDKKNDGSQKKIVLLSAIGKTYEAKASSVDDKSIRIVLSDSVEVSPGIPADLRLTITPPGSKSISNRALILAALGSGSCRIRNLLHSDDTEYMLSAVSTLGGTSYSWEDGGQVLVVEGNSGQLKASDEPLYIGNAGTASRFLTTVAALCAPTDTATTTVLTGNARMKLRPIGPLVDALRTNGVAIDYLEREKSLPLRINASNGLEGGEIELAATVSSQYVSSILMAAPYAKKAVTLRLVGGKPISQPYIDMTISMMKSFGIHVTPSADEPDTYHIPQGVYQNPAEYTVESDASSATYPLAVAAITGTTCTIPNIGSKSLQGDAQFAVKILEPMGCEVHQDDYTTTVTGPKSGNLKALPSVDMTTMTDAFLTATVLAAVAEGTTEITGIANQRVKECNRILAMKDQLAKFGVVCNELEDGIQIIGKPRESLTAPKESIHCYDDHRVAMSFSVLSLAAPGPVLITERECVGKTWPGWWDVLSQQFKANLEGVDTESSRETKPKAPAGIQRSIFVVGMRGAGKTTAGKWVAKTLGWKFMDLDHELERRAGMTIPEMIAGPRGWDGFREDEVNLLRDVIQAHPNGYVFSCGGGLVETPAARELLKSYGANGGLVLLVQRDTDQVVDYLSQDKTRPAYTTEIREVYERRRPWYRECSNFLYYSPHSQGSASVAEAEIPEDFTRFVSVISGKSRTLETVSKKKHSFFVSLTLPDLNDAVDILPRVTADCDAVELRVDLLKDQQPQAVMKQVSLLRHLTGKPIIFTVRSESQGGKFPDDNNELRLALYRLALRMGVEYLDLEVTLSDEVLQHVRESRRHTVIITSHHDPAGALSWKNASWISAYNRALQYGDVIKLVGTARSIEDNFDLIRFKSRMLAAQPTPIIALNMGSAGKLSRVLNGFLTPVSHPALPFKAAPGQLSAAEIRQGLSLLGEIEPKSFYLFGKPISKSRSPALHNTLFSQVGLPHEYKRLETDKVEDVVEVLRSADFGGASVTIPLKQDIMAHLDDVTEAVKIIGAVNTVIPTADESLGGRQRLTGDNTDWKGMVHVLRQAGVKAQSGGDASAVVVGAGGTSRAAIFALHSLGFKPIYVVARDASKAQSLASSFPAEYGVQVVASAAEAEAIASKPIVSISTVPADKPIDAGVEEILGAVFKSTSDLQGQSRVLLEMAYHPPRTPVIQVAEKVGDWKTITGLEVLAAQGWYQFEAWTGIKPLYSDALEAVVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQD7</accession>
    <name>A0A2T4BQD7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1395633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQD7"/>
    <dbReference type="STRING" id="983965.A0A2T4BQD7"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="334" mass="37463" checksum="A9CCCAA91648B8A8" modified="2018-07-18" version="1">MERFRNLLGGGGMGLGGVTPGTDNTSLIDNSETVYISSLALLKMLRHGRAGVPMEVMGLMLGEFVDDFTVKVMDVFAMPQSGTGVSVEAVDPVFQTKMMDMLRQTGRPESVVGWYHSHPGFGCWLSSVDINTQQSFEQLNPRAVAVVVDPIQSVKGKVVIDAFRLINPQLLMMGQEPRQSTSNLGHLNKPSIQALIHGLNRHYYSIAINYRKTALEENMLMNLHKHVWTEALEMDDFRTEGQKNKERLQRLVSLADGYEKRVKEETELTKEQLKTRYVGKLDPKKHLEDVGQELIEDNIVSVSRQMIDKEATMPKKNGALAQSNGDQMETEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQP6</accession>
    <name>A0A2T4BQP6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_213141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQP6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="17099" checksum="6E5F93B7EB9C99D2" modified="2018-07-18" version="1">MSFVFASFCGYCFGCLFERLSRLLVLFDRDVQVWKWVDFGCIGPLCCYLTQLARGPVLYIRYLVCLGFSVAIGYHILCSTGGPRAWSCSIFAVSISRLTCCRQPLFSEQDNGGSRSLFKHVLSLGQKGAIFNLLAACNSIDGPEPLYLGIVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQP9</accession>
    <name>A0A2T4BQP9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1395561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQP9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQP9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12487" checksum="6B345D26900B6D41" modified="2018-07-18" version="1">MGSIDIPSEQWAQVVEKTGGPVVYKRIPVQKPGPDEVLVNINAPVFDTVIRMITIKGSYVGNRADTQEALDFFRRGLITVPFKTIGLSQLQDIYTLMHEAKIAGRYVVDPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRB5</accession>
    <name>A0A2T4BRB5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1473252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRB5"/>
    <dbReference type="STRING" id="983965.A0A2T4BRB5"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="349" mass="37846" checksum="01C5FEB6D2FC19B6" modified="2018-07-18" version="1">MANSNLLVLTGATGFLGSKVLVLALEAGYNVRIVVRSVSKANKVFNAPSIKALSLSAEKLSHVVIENMEVPGAFDEALKGATHVIHCASPIPSFGGVAPTQEHYHEFFINPARRVTTNLLESSRKADTVKRVVITSSVVANVPYQYYLGQGDDKIFTADTRIPVDKGPYGSEMQAYAASKTASLNDSEAWVAENKPGFDLISILPGWIWGADELATTPQDFETSSTNSVLLAFLRGSQSEVASHVNSVLVDDCAKLHVLALDPKIPGNQAFLAVADDINGKEWKDAIEIIKEKYPEAIEKGLLKTTGKQPTIRIRLDAKKTEEAFGFKLAGFDEQVKSLVNQYLEVIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRJ5</accession>
    <name>A0A2T4BRJ5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_22984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRJ5"/>
    <dbReference type="STRING" id="983965.A0A2T4BRJ5"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="386" mass="42518" checksum="333F64CF951DA4CC" modified="2018-07-18" version="1">MAGPAQGEQGDCGCFAVFSFYPKRRKGTKRNDTRDYPGPLTQAETLLAHIAVSPPTASPGPSAAAIHNEPLGSLDSDLWSRAYQSLDGKTRKWINDVSADKGGKERAQDLVINDLIKIVKKREEEYKDAAPTLKISGFKIQWIGYADRVVIWVTAIGNIAINPSPSTIPSHLVSSQDASQAYAFSRLSEGRGKQFLRALVSGGQGAKLVSRLTEKEHKVSRSAQGCGAMVSKQHQHLLKSLAGPLRNVEDTVKRLVKQIDSKALTEAREYISKIPVGDHQQEKRDSRTPKTGEWLLNHVRFLEWEGSDFFDSVASRQGASGQDGKGYTLSFYRRTIIVLDALDECEREIREALAVIFSNLVDKGEGTVKLFIASCKEKDIEVYLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRP0</accession>
    <name>A0A2T4BRP0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1102985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BRP0"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="17"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="947"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2302"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="947"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="2394" mass="258765" checksum="D2E7586472D1A8EB" modified="2018-07-18" version="1">MCEPPSGDSAGVGVASMGDIAIVGLALRFPGDATSPQKLWDVLERKESQWSEFPKDRLNIDGYYHPSNERLGSLSFRGGHFLKDDISAFDAPFFSIPTEEANAVDPQQRMLLEISYEALENAGIRKEDIDGSDTAVYVGSFVKDYEYISLRDQNWGPKYAATGNGIAIMSNRISYFYNLHGPSMTVDTGCSSSLVAVHLAAQSLRSGEASLALAAGTGMILSPETMLPMTALNFLSPDGKCFTFDSRANGYGRGEGIGVVVMKRLPDAIRDNDTIHAVLRASCVNQDGRTKGITFPSGDAQVANIRAVYDSAGLDFGQTGYIECHGTGTQAGDWQELQAISQTIASARSVGNPVMVGSVKTNIGHLEGAAGIAGLIKGVLALERGLVPPNINFIKGNPKIDFENWKVKVPTEVVDWPIPGIRRVSVNSFGFGGTNAHVVVDEAPGYLATKGLNANHSSADIAPSRTDAVLTEGNPEARLFCYSASDNGGVSRILKSHVQFIESIRNDPEDSLRNYSYTLGCRRSNLEWKGFIVAESAEGLLAKIRDFRTSSVARSSLKRQSRLGFIFCGQGAQWAEMGKDLMSFPVYSASLKEASCFLQLGLGARFDLLKEILRGAGDTRISDPEISQPATTALQVALVDLLKSLNVQPQFVLGHSSGEIAAAYASGAISRCDAWRIAYFRGLAAASIPFRASKLKGGMMVVGMSTEEASAYLAKINKSAQIACINSPRSITISGQAEAIEFIARDLTQNDIFNRILNVKVAYHSSHMKLVEDDYVAALEDVATHDCFEGVTMFSSVTGKPIRGSELTARYWAKNMVSPVQYVAAVQSLIGLPADAQPDILVELSPSAVLRSPTTDVIATIKSAASPEYHSALERRKNGCVTLLTLLGTLWSRGYPVDMKKIISKGEHEGSLRCLSNLPSYTWDHRKTYWHEVEMSRESRMREYPRMDLIGARVLDSMTSFEPKWRGFLRISENPWIKDHQVQKTVVYPAAGMVAMVLEGAAQLAKGSENLLGYELTDMGIEKAMTIPDTAYGLEVSLSIKNDLGSTDDDGKIGARSFSVYSRLQGRVWERHASGILRFHYKAGNWQGAFRSYEDRYEAMRKSCNKAIIPRQLYEHLDSVGMNYGPLFQNIAEVRTCDGHCVSRVRIPDTKSKMPCKFEYPHLLHPATLDAMIQTLLAIKSVPMVPVSIKRLYVAANLGGAASGADFAGYSSVSSAGIRNAEATIFMKQDSIDQAHVIIEGLGLAALPTPSPEEGGFLPSNRNLCSQIIWKEDAIFARPSSYDEQVALLAHKYSGLSILQVGGTFELSQATLKAVSPDPDGPPQLVRYTILGGDGDGDDVAFRLLSFVRDTPLQPFVEEISDIAAVENDYHLIVACNDVDTEFGFLEARLKEGGILLVQTSPQEEQQMFEVQRASGVQNLSSTRGIADDHLIPGEGGHHVHFRESEGGLVLRVHRKAQLSHSIGPLVVITPAEVGTEVQNFLKAIERRQATDGVSLNASFATVDRVLEDPSALNGKTAISLLEFSGTQPRDYSIFDWGKKDFDTFRGIMDHASHVFWITRGALMSCENPRGSPISGLARTLISEDPLNSIVTLDLAGDSKLDDPVVFDNVLCLLGVVVGSWPVSVQDSEFAEAGGKIYIPRLGTLRSLNHIIEGEDLAGRFSQMPFGDSQGLQLKVDTPGISDDNLFYIKSDTGNLGPDEVEIAFSESHLSLLDLETLLGRSQKSTVGADVRGRITRLGGRVKGFSIGDNIAALVPGGSLRSLLRVGSQFVKHVDADIIPSLLVSAYFALIHIGRVRRGRRVLINTGACSFGLVAVDLAVAVGAEVFATVVGPNAHLQREILKRHGVSEDHILEAESGLFVATLLGATDGDGVDCVYNPTLKAFDELFDCVRKCGSMVQFSREATGPTSSRMPPTSVTVANWDLHQLLAEDPSFVAELLDLAVQFIQTIDFKPTVSAELKQVFDIGSLKDALLCLQQSPLVGLVSVTAAEDGSSTVRVLNESTTKPLQETLDPEGTYLLAGGLGGLGRSIAELLVQNGARHLAFISRSGASSDAAKSFLQSLQSRDVDARAYSADICNKLDLEVVIKDAITVDMPPIRGVFHCAAVLRDSVFSNMTFEDWDTAIKPKTVGSWNLYHGLSAAGHEPFHIFLASSSGIIGNRGQANYAAGNCFQDSFARHLRHQGKHAVALDLGPVLGAGMLAENEDILDTLRSNGFFGIPHQDFLTVLKHAITGEMEPGVPTPPQVTVAVGTGGMNAQINAADPYWTRTALYSYLNLVDIAPPNLLVGGDASKKDMKAMLAAAASFDEVSAIVRDGLSAMLAKTMNMLPFEIDMKKSLNAYGVDSLVAVTIRNWILNNCGVQVSVFEVLSDLSIADMANMIAEKGGMGEAGRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRT3</accession>
    <name>A0A2T4BRT3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1097540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRT3"/>
    <dbReference type="OrthoDB" id="4900063at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="12080" checksum="029C682CF349305A" modified="2018-07-18" version="1">MRRYITRLKRPHGYKRPLSESAAKKRMHAKLLEFEARFNSARTYDHFCEPVSPSVVPYHHAEVMDIVAPWMYPYYDDDQSSGMYPHYEDNHLSEMMARVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS16</accession>
    <name>A0A2T4BS16_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chorismate synthase</fullName>
            <ecNumber evidence="3">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_23712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="3"/>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS16"/>
    <dbReference type="STRING" id="983965.A0A2T4BS16"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="53" mass="5853" checksum="C8DB90AB223B1B40" modified="2018-07-18" version="1" fragment="single">MSSFGHYFKVTTYSSRAGESHGKSVSCIIENCPPNLALTEADIQPQLNRRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS57</accession>
    <name>A0A2T4BS57_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1442156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS57"/>
    <dbReference type="STRING" id="983965.A0A2T4BS57"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <source>
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    </evidence>
    <sequence length="504" mass="54397" checksum="628EFAA5C360763B" modified="2018-07-18" version="1">MPTSASPPDHQQFIYPTAPTSFHDDDRSSVLSSDDEGDASSGASDPVLRRRQIRTKQIVRFVSLVSATIAALCAGSIVVFSLYAPKFLSRLHYTHSVSTCAKNFGKGKYRGLALAMPITGFGLSGMWLSQFASRFLYEKNPDGSKGDVDVFRFFVFLAALLFVIGILGVFTLKVVDEQDLIEEAIEELEQSGLLDGSSLLARSESRRSVSGYGAIPTNAEEDGEEVVGDDARWKKNWVLNAETRRFLGDHTMWPFALAFLLMIGPGEAFINNLGTVIGTLTPPITEDVNHKTSAATHVSVFGVTSTLARLMIGTLTDILAPAPETQHVQVAPSRPSSPLKRFAISRVVFMLFFALLLAIGLLFLASGAAQNHADRFWVVSGLVGAGYGAIFSLTPLIVTIIWGVENFATNFGIIAMLPAFGSTFWGLVYSAVYEAGARHTTVPSHLGDDHGDGGDGGSDDSVCYGKHCYAATFWAEGLCVIAACFMLLWAWKGKGGWSQRGIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS61</accession>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">ATCC 18648</strain>
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            <dbReference type="EMBL" id="PTB72139.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="248" mass="27914" checksum="DA74A87FAC1784BB" modified="2018-07-18" version="1">MPPLQNAPLLPHIHALCMDDIYSTALQAAVASSDSLSSISITYHNCALSFVEAEFDLIVSPANSYGRLDGGFDDAISRSFSPRDDYLALTRVAQAKLYDEWRGFAPPGTCTLLRIPDEFHARSRNAWGTRYLALCPTMRVPQSVTWDREVVYECIWSLLCAVDRHNRAVRNAQSQQQQQQQRHDEIRSLLMVPMATGVGGVSAEKWAKQTALALEHYLDAVTNESRWSALQPDDIQEYAREVEQTWAL</sequence>
</entry>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grujic M."/>
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                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">ATCC 18648</strain>
        </source>
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            <begin position="18"/>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="247" mass="27727" checksum="B602764DD8A624D0" modified="2018-07-18" version="1">MADISLERMHAFSVNLTLHGFRRFKTTHLLNLRYIEAEIAEIDHTIYQLGLSSNVAPSSTDRLGLKHYDAIIAFNTIMSMDTFALLDDEKSSSFRTDLTLYEMYKTRLLRLDQLPRTRQDHLQRWIHQRLRDSQYSRMSRSTQGDVESTASTAADRQWYSQNTALIADVVSRIILGVVTAIFLIAPLVALSYESRKGIQIVIVSVFVVVFACLVSAALKASSLEMMLASAAYAAIISVFVSNSPEPG</sequence>
</entry>
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    <accession>A0A2T4BT76</accession>
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        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
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        <name evidence="5" type="ORF">M440DRAFT_1341807</name>
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    <organism evidence="5 6">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreaceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="entry name" value="PH_23"/>
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        <property type="entry name" value="PH_24"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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    </feature>
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        <location>
            <begin position="1515"/>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1479"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1671"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1899" mass="207345" checksum="FC432BAF13B6A8CE" modified="2018-07-18" version="1">MTSSNEAPGEGSAPPNPTTPTNLSEHSKSGGSKDGSATDGKKTPGESPKSAPAAVTGGRPRANTKKTEPPSLLHDFLLGRPSPARLQAERKRRQSMDTVKAEARHEMRQNHVRKLQPPSGVRDRVKTWQKANAAAMVDSNPDDAATEPTDVAFAGEEMESVTEEDRVRIKMRQKRRPPKAIVHNGGPKSEADKKDKEVPPPPKKRIVSDDNWVKPKVRKPSVRKVSPPDDDGIRVAPIKPSDDGIRVTPKKAADDGIRVTPKKATDDGIRVAPKKSTDDGIRITPAKPSPAAPQDDGIRVKPVEVKESKDGIRITRMKVTPPPRDDGIRVKPVADSRSEPGTPRPTRQRSKTAGAASKKHTIHDLIKAVEEATLLSMSDGADDLDSYLDAPAEEPRPKPRQGGVKRSGTKRPNTRAKSADVGSRAKQPPHIPDSDLGTTLTDRSLADIPGEIPFGHSAFSELDLPLRGPPKSKPKQQPQQQKKTKLDRATSLKAMPNVLKKVVEEGKKIIQEINEPSRHATPNNPPSIEKWLNNTVEPYEKGNRPPSLSSTLSDEDDEDDDVTIGEAAPRDISREARREIRPKETTREIKPKEAVRETKPRESRETTPKKTASRETVSKESAHRVSTSRETAHRRKPSAETRSSMVSESRVVSNVTSDLSSNLTSSVETTHSEETTQSANASSPKSGSRTSRDSGKRNSPSSSSLKRRSATRDSLPSSKSGSTRRPFLGALKEAFQGESATLTKPIKAYQSQEERRFASDDESLEDDRTELEADSQYMQSNSDLSSWATTETRSSTDRDSSVRSSSRGAPPHIAGPRLRPPTNGHELSTILSEGSSVSHSETESDVSRSTLTRSSTVSKSTDPRTPQRQGSGLKRRLTKHSDLVSVLSLPDDANVPQRIKSNRSRPSLRKARGLSNNVTADDLLKEFADDENLFRRELRTLVDGVIPVLLSHVVSDTTPASELFGAASAKGKVDVTSKSVVNMGVVLEKLKNAHDKAPLNDIRRMANWAHGVVPIYNNYLSVWRLGFQDLIVSLAPRRGTADEDDSLLNALPRNANGDLINAQGERVAVAYLLKRPLLRIKQLARLIVCVDQMYPSPDSNQLVKDFEALQEKARQRHREEVARIIDEEAINTDTSRARDLRTLSPIKSVTIPASRQVSAKDIFSLDLSHSNGQRLECQVELVHRDNQSRPEDKGDLLIREVGDGRRSYLLFPPISMSLVSARAGDGKQDMIVMVRGNHNGRAWHELLNLWADEEEQILDWLDILPSSPVPPRQAEPSILDESELGSDSPGRLPDVPVGVQSMVSVATRSDTTDHDDSDSGLATPPTPTRAAPGPPGRPEPSATRQIPIIYHNDAPPPRPPVHRTLSPTPQQSPKSQSLLKPPIDLHANDRLKRRGSSPLKHEYLPSEVSSASGLSSSAVSSIVEEGEETESEGEDVSGTESESESSDEEMESLDIPQTELGYSIREDDRRRGSYAPSFAPSNTPASEVSLTPSNSASQAGLHGRKPSEEDGSIARSGRCLATVSRWSDKGAWKDVHPDHCSIMVTDGLIEAFAFRDSNYTQLDDRPIVALDLTPLVLIRQSTAVDLEIRSSMQPHSKLAPVYQGGNFRFRCLNGPDCYTLYTAVHHARLNNQKFIQLENEARFRSFGERPAPPDEGDKSSRRSWFGRKNSYRSSVRAPQSQHFDGASTTPSSTLSASSFLKKLTLVGNLSFNLARSSVDKRGGRGGSGNNSLYTTGSSSGWGSPRSPSVSVDNSGDVPVNFGTDNIRIRLHLLVSPAKWEDYGNCSLQIRRPPPGWRQALRADHGLEKRVTVTTAPKKSSEKPIVVLDAVLGSGCFTPMGSRGIVCGVWEEVKSGDGVVGGVPANGATGGNIKKWCFQFASVAEAGWVLRLVHQEVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTN5</accession>
    <name>A0A2T4BTN5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTN5"/>
    <dbReference type="OrthoDB" id="4867982at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015648777" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="8499" checksum="2DBB91764A6B4537" modified="2018-07-18" version="1">MKTAAFIAVALSGLALAAPTVQHAGEEWKDLTHLKYANSKPIALADSKAEKRAASAVPVKDNRNLHYSNDMPIAKKPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUQ5</accession>
    <name>A0A2T4BUQ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1340672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUQ5"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="429" mass="46776" checksum="FF10259CCA111451" modified="2018-07-18" version="1">MCHQDTDTSSPPPNSTHNDPFPWHLGAYDAHCHPTDTMSSLSPSSVAALRTRVLTIMATRSQDQQLVADVAAEHGLKDADSDSAKDCKVVPAFGWHPWFSYQLYDDTVPNPTYNPKPSSTDDASADEDAKIAHYRAVLSPTPEDRSFLSSLPTPTPLSSLISSTREYLTRFPLALVGEVGLDKGFRLPQQRPPDDDFSRDESITPGGREGRLLSPFRVQMQHQQAVLQAQLRLAGEMGRAVSVHGVQAHGVLYDTVAACWKGHEKKVLSRRDKKRIAPGAEEDSDSDSDDDDGQPTSDNDGSKAKKKKKNVGGKPFPPRICLHSYSGSADMLKQWFHPAVPSTVFASFSAGVNMGNAGGGKDGKDEKLAAVVRAVPDDRVLVESDMHAAGGEAEALLEEMYRFVCEVKGWGVEEGVERMGGNFRRFIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWK5</accession>
    <name>A0A2T4BWK5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1424272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BWK5"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="10">
        <location>
            <begin position="385"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1368"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="9">
        <location>
            <begin position="1868"/>
            <end position="1955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1955" mass="221858" checksum="C90CD811A9C37465" modified="2018-07-18" version="1">MDDNIGASHQGPPAALSASAASHLLASFSAYEPISRSTSPGLPFPKSDDDDKRRYRQRTFAYFRQLPFEVEEEAQRDAALQGILKQLYIAIQAEDFSPGALHWTRELQGWLNLKFEMTRELRAKLAKLYYSLALAPGVDGNAADRFVRMAVNLTRKNHYLKPGEDLTLDWKPLWAEVKAYVLPSEVPAHQSHRRRAAKQLLRLTINAHTYFDPRERRAMLQEFLPYFSLNDLQNAFVVIGALNSLLPSHPAPESEVGSHPADFFPTLFHLWSLVNRSKTVDVAFIDLFSRIARDHSNCSYVPFGEHGIFTKAQSDVIFTAILRLTLIPVGQANSPYTPLDYLAGTGVYFEKDKKKYPIAYMIARLIVSSLSPICCEKEESIMSSLEGLIESIDTFFHPSNQGAWSGMLAQLILYLTDAFVSRWNREQSSELEVPNERKINDALKQRFVNALKEVTFMGIFSKSTRVAQIYTNALQGLAYLEPDLVLPGALQRFYPSLQGLVEVHRTTSSLNGLQMIANIMSKLKGYRCHITALLALALPGIDANDLNKTQYTLHFIQAVAYSIPIVPLTSGESHIHDTTLAMEWVQGEMARMELEGQNVKIDYNAELTDEDESMILRSSTAGFGEFLITLLGKVFTLLENLPDANQVRGGTPEDSVVNALPAALSPLFASMSPELFDIALEKIATFVSSHVVHQARDAMAWILNALCKVNPEKTLKVFIPMFVVSIRNEIDLNHAASDRTSGTDYLPRDRALVWHITMLAMSVVHVGREVLNYKDELLGIAQYMQEKCRGLPTILVSNYIHHLLLNLTHTYPIDHALYEPDVLERGLDVTDWGKTTSPADLTIKWHQPSPPEIEFAVELFASQTKSAAEQLELLLSDAPPVARKGKNKEWSDEVSRLMQQIRLVISGMATMFDPKRASGEIAGKDSGAGPDDMDVDAEDEDPLAEVAEDEELRPQYRYKAGYLLSPSDPVYERIHDLREQLGQLLTKTHSFLSQNEEDDVDCFTTLYIAYRTWITDVGIERSAHPLERHLRLYKSDIAAFKIKGLRKVYPRPLLIKRAEAYQMSRMKHNASARQKSELDKRLLLDLAQSCLSSYADVRRVAQSAQDSSLKVLIGGKPLVIPVILEGFRKSIENNDHDRIKGAMYSLFLTSLLRTLMRDWRFAPDAMKLYIQTAGIDKPSIQTIGSSVIYSLIEFGKQLERSVFVNASLVDTIKPAEDVSQAIDNRRRFILQRREKVEASKADLGLWLTRLAEGAHWKIASRCAIFATNLCLRFDTIAPPEFVDLVAKGTNDPHPGLRNYYLSAFTTLFSTIDMRAVYDHDFNNYLLEKEVDYRNKIQVPVEKGDAEFTKKFLDSFEQHPSEAEYMVDSDHPGWLVWGKSFTAFSAKPKPFDNYDETERAVRDQIGKILTKDWLRQCFAYLKQEPRDANTDRFRMHNVYLLMHVFDLMHYGRTAIVQEDVEDLVREVYGDGNDKHQHRATAEILGALLAGSSDDPPEIRNKAWKYAAPFMLKILDEDLTPENLQYWLTCLHLILDSKDPRRSYEIIDDLKTFRLDMSSNAAFKESSKIQLLEFAVADAGWHFRGVQPILDDFLAHIDHPYKAVREAMARVLSIIYKTRYYEAFENVQGLLDANKEASSIGLRPYQASDDLTATMKDVFDRLEKWRLERAPGQQEQSPYTCGSKTVLVWLDCTLSSHECTQLVPFFATPFMDQLLHMMDVKEDPELMKLAYHVYRHLPNIPFRDGEDAEFIEGLVRIGRTAASWHQRLRALVNMQVIYFRRIFLTKEPQRDRLFTTVSDMLGDNQLEVRACAATTLAGMIRCSPSRIRNPMIARLKSRFEKELDQNPMPKRGPKLPGTETPVDVHKQINRRHAAVLGLGALVEAFPYATPPPKWMPEVLATVARRAAGDPGVVGKAAKGILSEFKKTRQDSWTVDQKYFTQEQLEDLEGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWK8</accession>
    <name>A0A2T4BWK8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1403899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWK8"/>
    <dbReference type="STRING" id="983965.A0A2T4BWK8"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="17724" checksum="BDC9AE80FC3BB53E" modified="2018-07-18" version="1">MATPNDQFYIRYYSGHMGRFGHEFLEFDFRVVGDGRSAVARYANNSNYRNDSLIRKEMCVSSAVIDEIKRIVKQSEIIKEDDSKWPQKNKDGRQELEIRLGGDHISFETAKIGSLVDVTESADPEGLRVFYYLVQDLKALVFSLIALHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWW1</accession>
    <name>A0A2T4BWW1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1440742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWW1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWW1"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015437554" evidence="1">
        <location>
            <begin position="20"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="358" mass="39153" checksum="66FB788FD7D89B52" modified="2018-07-18" version="1">MRAIYALIDTILAAGTVGASSPHGHHDTPKVPAFVLDFAPLIALHQGEIFFPSDIGQQLVHTIPRVNFTRVDKGSHLTLDNLNGLNKFGNTSVFLTSKDDVTDLAREPSWVRGVKPNGRGKTIIQSLVPFTFTSMPSTMEDMSPEFRRTCMSLTGSTPWSEAGEAFSYDALQKIGKRVLVFSAFGSHANYATKGSHNLPFVTPPLPAINLSSISIPGIPAGVLDHLNLSAILQAVLPANFLQDKTSMGPLWDPVANAFAYNYTFDFNPHRAAEENNRFAPLATKSHANPPSNWLTYFGQWGDEQYPLTDVRQFEILNIPSLAYFMSGPNGPVFKHLIRSSVCPPGVNCTIKTSLDQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWW5</accession>
    <name>A0A2T4BWW5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1424414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWW5"/>
    <dbReference type="OrthoDB" id="4857897at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="211" mass="24556" checksum="13E0D3484AB22F0B" modified="2018-07-18" version="1">MYGNFQRIPYPIHKSPMDGDTAHRDLDWVYASQTDRIYALRVGEFGVTRQQKLDLLQNVFWPALIRWVISRQQILPGGTILGGWWRADMQGMMDWYRECLHMTARWEDAIIAHTDGIWRTALETSPWRDWPEFFLLLNEPVVDDKGQVVRDAQGRIVYKDRDPTVDGMEDAFLDLWEAIANSRPLANYVKQDARKDGNLLASRTRATDVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWW7</accession>
    <name>A0A2T4BWW7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1360565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWW7"/>
    <dbReference type="STRING" id="983965.A0A2T4BWW7"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="31"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="527" mass="58397" checksum="BA723E61F7EC7D1F" modified="2018-07-18" version="1" fragment="single">MAQTGAQTSRMITYFNSDDFKDTATSILNRFRVPGLAVAVVHNKDTASRAFGASAFASQPPQTAAKSMTTQTLFEIGSASMSLTAAAVALLVADERYPDVRYDAEMAELLPGQFVMPGKKHMGVTVEDILSHRTGMAPNEDAHIGSCSPQRDDAQTVTLNIRNLSTAAPIRSRHMPCRLMYTAASWLVERKTRKVFADFLDHRVFAPLGMTMSSLWLSRARVKGHGDYICPGFSWDPVTGYCCFHKTDSAAAQGAGLIVTNVDDYIKYIQAVMNQEPPFTEAVCEGLLRPRSIVSHADEKLLPLRSPALCAAGWEVFYYRGCKVVAHGGRTAGSSATSFFLPTLKFGAVIFGNMEIAEVAGELLMQEFLDEVLNAPQEHRFTQDQRIQLLGRSRLHGDAFPTRAALAGVGASQPNLDQEIDGQKMLLKTYVGEYWNPGWRGIKVKVNVRTNRLLIDCSDRLRGFTLTLERFAGQTMYLAKKQYVTGETGSTMRVEFRFEHGCVRRVGVWLEPELDDYIWFERTAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX67</accession>
    <name>A0A2T4BX67_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1360741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX67"/>
    <dbReference type="STRING" id="983965.A0A2T4BX67"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000920">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="86"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB73845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1181" mass="132306" checksum="B6F4174D353629D1" modified="2018-07-18" version="1">MGTISFDINDALKHYMSDPATIPTPEADAALFDCENDPEALTNQVINPVLNPIIDAVADNPDAILRAVNIDSLQFLLKYTPYIPAHILSKVFDLVMSGLSAEADAVHNDIESPDEQDSVAHHKQLLEIYGFLLQWTIAAVETKAAEKSSAAPVARGRGKPKKASQRDDVWDSASQLQGALEIMCKTLKLKLSRIFLTTSERDTFVGLLTRPVYMILENEQRVKATTIKMHCFKVLCIAVKHHGHGYAAQINVIQNLTYFEHLSEPMAEFLHILAETYDYPQLTDEVLREISNKEFNSNDTRGPKSVSAFIAKLSELAPRLVIKQMTMLAKQLDSESYTLRCALIEVCGNMIAYLSRQEERSENHKSQLNAFFDVLEERFLDINPYARCRVLQVYVRLCELEQKFPKRRQKAAELACRSLEDKSSNVRRNAIKLLGTLIKTHPFTVMHGAQLSRKEWQARLDKVDEELNALKPPPGIAGLADATVDHSLLDEATQVASPEKPRQMTDQEVFEAVQKAQAEAATSEAIEKLTLTRRYYNEALKFIDVLHDATELICQLLGSRNKSEVIEAIDYFEVGDAYNIEQNKVGIRRMLRLIWTKGNSDEGKGVQTHLIECYRRLFFEAPDSFSPNDAANYIARNMISLTFGATPAELTSLEQLLATMMKGGVIHETVVAKLWQVYGVQKREISKTQRRGAIIVLGMLASAIPEIAVGEIETMLRTGLGAHGRNDLQLAKYTCIALRRINPTGRQAKESTAKFSRLPNDHAVCSRLAAIIDVPSDSKEWYGVAEQAINAIYALSKHPDILCSAIIRRKAKEVFGRPISRPNSRDQHTTPEFADPRSPGAMPASQDKPKKRDDAIALSQLLFIVGQVAIKQIVHLELCELDFKRRKQEKEKQAPSKADKDKEDADELDLIGGTTEDDFTEAMAHIRERELLYGPTSLLATFGPLVSEICANNTTYADEGLQAAATLCLAKLMCVSSEYCETNLPLLITIMERSPDATVRSNAVIALGDMAVCFNHLIDENTDFLYRRLADTDVSVKRTCLMTLTFLILAGQVKVKGQLGEMAKCMEDEDRRIADLAKMFFTELSTKDNAVYNHFVDMFSLLSAGDMEEESFRRIIRFLLGFVEKDKHAKQLSEKLAARLARCETERQWNDVAFALGLLQHKNEEITKLISEGFKIVQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXF8</accession>
    <name>A0A2T4BXF8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1339188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXF8"/>
    <dbReference type="STRING" id="983965.A0A2T4BXF8"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="827"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1112" mass="120003" checksum="F9F4845719917D6F" modified="2018-07-18" version="1">MPPKRLTRARAATKEPEAASLSSSTSSSSSSSRPAKIVTAAAAAAAAKARAPLSSSLTASTASTAAKRKTRSDDAEEEQRQATQVKRPRGRPPKKPVGGDQKGVAMAASVLATTTSKAAEPPEPVKRGRGRPPAAMKPATSTTTIANKPPVKKMVTFREPDKENMEPAAAPKEPPPPTGMRGRPARRGGAAAGRPGRPPTKASKPQGEDKRPLSPKKITQLIHSRTDSADESEDELALEKVNAKPLSKSPIKPPSKKSEPIPAEIEPADTNIAVNAMMFDMPDMTSTLFTSPARRPTSPPRDTIKSPAKRMAVPLPGSALKLSSDAVAQTPFKSSAPNLLQSAAKRPQSPMKPFIFSAQKERPGESSTKPSMLHSPAKRAMPGFKPVLSAHRGLPTLDETPVGTPTRAARSSTRLMMEVAQEDDEEEEPFEGPIEIPRFSMSSPAGPSSEARYAVTEVEEEEEEAADAEPVDAEDAEVEEAEVEEGEAEDAEAEDAPQPNPRFSQLRQKDLDPCHDMSSMSDSEDDTLPFERSTATPSTSGERTTSARASRSPVKQSRRSTLGFGALSDQLGTWSAASPVKSARSFVVENEAEDAEEDLLEHEVDASNPDTPMKNAFSGSERLSMQPEGIALPDMGDAEDQQLDEEAMITDEDLALAQEANEMSLMDPKEEDAANTRHSFDDSLSDASQEYGDENQVPVESPTPSAAPRAPPPVTPVSRPVTRSFNTTTKVPLKAADNSTPSPLKKKSLSTPRAAPKRSSQPKRTAPVLAYTPERPRRRSSRNISTISEEPEQSAEEPSMPEPKTPEAKVDLWASIGTPARTPRRDLNPNLLRGAIVFVDVHTSEGADASGIFVEVLTQMGARCPQKWNWNPSSASNTESTKVGITHVVFKDGSKRTLEKVREAKGVVQCVGVSWVLDCERDNKWLDESPYSIDTGNVPRGGARRRKSMEPRTVSNKDGSAVSSSSEKRRASSSSASSSSKTPNRRQSSIWVHTPSDPGDEEQEEEDIEWSNLILTPVPKTPAPETLMKFAAETPSNLETDEEDEEDASPTREELMTRTCPPKAQKYLELGGGILSRSKDSDENVMQRLMAARRKSLQFAPKVGSPLAKMWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXI4</accession>
    <name>A0A2T4BXI4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1055786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXI4"/>
    <dbReference type="OrthoDB" id="4896490at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="267" mass="27589" checksum="F6DCE394A5527B45" modified="2018-07-18" version="1">MAAQNKFTTCTFVLKKCDFSSPSLAPTCVKNFCQGEPYGFGSCTADFTGVPAECCSQSTVGDVAQCMANFQQQQGYGIFGDACLSVERYVTECENANSGFDTATFEQQASCLCYDSNNNYAPDMWDDAVATCVSTGESAHPTIWRALQRNSEVVGLCTRFAGAAATTGPATDGPIPTDSASLTATDDGSLGTTAADTATPTETGSRAAGTTASSDQTSAASSVTRSAAATTTTSSSAAARMGQTSYIQMKWAVVGLGLVLPSFIMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXR0</accession>
    <name>A0A2T4BXR0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1393251</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXR0"/>
    <dbReference type="STRING" id="983965.A0A2T4BXR0"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="54"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB74108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="415" mass="44724" checksum="5B716544535E435E" modified="2018-07-18" version="1">MLSRSHRSLHALSCTRRALGAQLRSPLSQQAVRRKSGPYGYTQAKALVFSKNGEPSEVLKLHTHSISPSLPKRSVLLRALAAPINPADINTIQGTYGSQPSFTSLIGTPSPSAIPGNEGVFEVVATGDSSLPVHKGDWVIPAVAQFGTWRTHAVADVDEVLKINKEGLRATQAATISVNPSTAYRILRAYGPSAGIGSGLGMRPLEVGSGEWFIQNGANSGVGRAAIQLGRLWGLRSINVIRERESEDETEALRAELTELGADVVVTEKQFLSREWKDQLAEITNKGRDHVGLGLNCVGGKSATAVARSLSESGTMVSYGGMARQPIALPVGLLIFKDIRVVGFWLSRWNQQDPAGRKHMIDYIVDLIRQGKMQDVPLREVAWNWGTDASALAQEVQDGLRGFKGGKGIFVFGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYL0</accession>
    <name>A0A2T4BYL0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1403765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYL0"/>
    <dbReference type="STRING" id="983965.A0A2T4BYL0"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="49"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB74398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="22610" checksum="2127247042C67E1E" modified="2018-07-18" version="1">MSRLAHSFLTTPIYKAIATSTRSIPEPSFFSTLFPLQKNLPPRPKPPPDSEIEESYLKGSGPGGQKINKTNSAVQLKHIPTGIVVKSQATRSRSQNRKLAREILAQRIDELTNGDQSRSAIVGAVKKKRADSAAKKSRRKYKLLEEEKAAAAAAGADAEAREAEVEASEAEAEAETLAAKDSTRVISEQSSDTGQGAGSQPSDTAAGGSHQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYY3</accession>
    <name>A0A2T4BYY3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1444836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYY3"/>
    <dbReference type="STRING" id="983965.A0A2T4BYY3"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="154"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="395" mass="43670" checksum="5AA60F63A9EB7277" modified="2018-07-18" version="1">MAAPLHPAVWASIWLAALPFIFYIALVGLGVIPFFQRHFLYAHAVHSLWWSDINSPMGWGFAKNQVTPFGLQTSDGETIYAWHILPLPLYLQHETTVATQDVGFCNDFTQTESFRLLASDPEARLIISCKYISLHNAGHIAQNTRPDSYHALTDTSSYHVIAIDYRGFGHSTGTPNERGLILDAAAVVDWAINVAGIPSNRIVLLGHSLGTAVASGVAERCTLQGVEFAGIVLVAAFSDLATMLSGYRFGGLVPALGPFAFWPSFERVLDRVLVDKWHSANRLGNIVRHSRGRLRISLVHAKNDKDIPWTEDNKLFRAAAGEAIGILDDDEYNAWKETLTVRTSNDSFVTTWKTGEDTVIRQELFPYGGHNNILGFAPVTLAIMRAFELEGTTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZL0</accession>
    <name>A0A2T4BZL0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1440179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZL0"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="124"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="248"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="373" mass="40909" checksum="B6B1DFC83732AF88" modified="2018-07-18" version="1">MPAIAGGLTPLHRWTLSASDSQFNALSGAIGGFTSGVVTCPLDVIKTKLQAQGGFTLVDKGRHVGHPKLYNGLVGTAKVILREEGIRGLYRGLGPIVLGYLPTWAVWFTVYNKSKSFLHQHYENPHLISFWSSIIAGASSTIATNPIWVIKTRLMSQSNPNTARGHHAFARPGNTPTARPVMHDWHYRSTIDAARKMYTSEGLSSFYSGLTPALLGLTHVAVQFPTYEFLKTTFTGQGMGEVQEGEKAHWTGILSASILSKILASSATYPHEVIRTRLQTQRRPVAGEAFVVEMAAPGAKPASGPKYKGVIMTCRTILQEEGWRAFYAGMGTNMMRAVPAATVTMLTYEYVMRELNKKKLQALEIQRELQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C068</accession>
    <name>A0A2T4C068_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1471474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C068"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015743827" description="Glycoside hydrolase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="28162" checksum="718E5F44D3F26DEA" modified="2018-07-18" version="1">MVHKAIVASLLLGTAIAVPTSSNRDAVSKAVSKRAVGEIVTSTIARFDNSNGADGIGAGADSYTLYLGDGSVGAGWPDQTTWVSFDDMFAANKATMLSSCTNLGGEANTSEDEVQAIHDGIEAAAAASGVDHRFILAVLMQESKGCVRVGTTNFGVRNPGLLQDHDGLATCNEGGVVQNPCPSATIAQMILEGVAGTATGDGLANTINQAGTSDVSAFYRGARIYNSGSISSTGNLESNVATHCYASDVANRLTGWVNSASACTCDSDPASCGVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0I3</accession>
    <name>A0A2T4C0I3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1431617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0I3"/>
    <dbReference type="STRING" id="983965.A0A2T4C0I3"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="326" mass="35729" checksum="6B4B363F3D741387" modified="2018-07-18" version="1">MTSEFIIKKIVWYGAGRLGSQILPHILATDKYDITFIGRKPPSEYKSKVPEGIPIVQVDLKDHSGIVQALTGADAVVVFTHFGPEGELDIVQIALINAAIEAKVKLFVPSEWAPDTAGGNGATLERIGPNTLPPSPAVAPKRVVHNYLMCRSAEGKIDFVSLHVGNLLLNVCAFSPMDLSQRTASLGDGGQGFISVSSLDTLAKGLDGLLRRYPKVKNSFFYICDGETTLQRIVKSFEAASETREPWEINSFSIAERKKMADKNMCNGIFTWKEFSAVLTIPFTAGLTVWQNPDNERLGLDSPSDERAQKTVDELVQRSMARGYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C182</accession>
    <name>A0A2T4C182_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_66770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C182"/>
    <dbReference type="STRING" id="983965.A0A2T4C182"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="478" mass="54436" checksum="FD79BACDC89207C1" modified="2018-07-18" version="1">MLDMADTDKMMTLAKDWADQYGDVFYTKVGLQHFIWLSSPTAVKDLMDKRGSIYSSRAASPMINMVSNQERLNFLPYGEKWRTLRNILHSALNLETTSSYKPVQDFESKQALWEILHAKDDTAFSDINRRYSTSTIMTITYGQRVPSLSDPLYQDILKIVRHFSLATAPGGWMIDTLPMLADIVPEWLLQNWKTVARQWYEEDSRIYLRMYNKLMTDIENGTAPNCFLKDMAREKIEKSLISDVTAAFAAGALIEAGSDATTTALNNVILACLLYPEVVTGAHEELDRVVGSNRMPDFSDEPNLPYIRGIAKETLRWRASTKIGTCHSTTQDDWYKGFFIPKGAVIVLNWWAIHMDESRWKDPQRFDPTRYLADPLTEAESMAQPDANLRDHFTFGAGRRNCPGVHIAHNSLFINIARLFWAFNISKAIDADGNAIEPSTEAQPGFLLTPVKFPCRLEARSARHAAIIERTWEEAQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1G7</accession>
    <name>A0A2T4C1G7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1392783</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1G7"/>
    <dbReference type="STRING" id="983965.A0A2T4C1G7"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="274"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB75355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="512" mass="56855" checksum="FC4401588D714CB6" modified="2018-07-18" version="1">MVVLAASICTRGGKAVLSRQFREMPRSRIEALLASFPKLAHSGTQHTIVEQDNVRFVYQPLDELYMVLITNRQSNILQDIDSLHLFAQVVSSTCKTLDEREIVRNAYELLSAFDELVTLGYRENLTISQIRTFLEMESHEERIQEIIARNKELEATEERKRKAKQLEMQRKESARSGRPAAAPRTPVYPTYTPPSQPSASAFDSYEAEKNKTFNKPTTLKAKGMQLGKKSKTTDIFEKVRGDLGAGAEDAPLITPTHAAVAAEPEPRISSTLDRDAIHVTIAETISAKLSREGAVNSISVNGDLTLRVSDPSLTKIKLGLHAIPSHGAQFRPHPNVDRNLFNSSKVIQMSNTARGFPINQGVGLLRWRATPKADDASACPITFTVWINKDSDKYNITVEYELTGGDALRDVSVVIPYQGSEPVVSSFDAAYEVSGDTLEWNIGSVDDENPNGSFEFEAESNDENDFFPMTVRFNKSTPFVDVDVTSVSLIEENEEVTFSKDVKSAADNYLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1J2</accession>
    <name>A0A2T4C1J2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1274715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1J2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="91" mass="10963" checksum="4981B0A3C36A69A7" modified="2018-07-18" version="1">MTIPGKSTQFHKKEERKERILKSERSRKEKFNEEEQSVYRTRYLRISQVAKGKSDCDPNQKRQPTSKQTHNMRVQRGTKRKEEKKRGKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2B0</accession>
    <name>A0A2T4C2B0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1402227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2B0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="16765" checksum="6DA73BF8C64794A0" modified="2018-07-18" version="1">MSSPRVYLASLASTPSFRRCSAPLQLLDALQTPLAAPSVTFPTARPATNAPSAANHSAAAIEVRPSSQPLSFSTLQGSIQLIQLTAIRLYCLCVWCVLALQRAIFPPGSQWVPGWRWRPGCKQVNKSARLVSSLPFDFDSTSFHFHSPPLPLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2S4</accession>
    <name>A0A2T4C2S4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UROD/MetE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1263045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2S4"/>
    <dbReference type="STRING" id="983965.A0A2T4C2S4"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="8973" checksum="00D72CB9D131447E" modified="2018-07-18" version="1" fragment="single">MVQSAVLGFPRMGVNRDLKKATEAYWAGKISQPELLAEAKRLRLAHWKIQKDAGVDIIPSNDFALYDQVLSHIQDFGVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3E2</accession>
    <name>A0A2T4C3E2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1334092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3E2"/>
    <dbReference type="STRING" id="983965.A0A2T4C3E2"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="270" mass="29498" checksum="2BB088E2C2ECD86D" modified="2018-07-18" version="1">MSPRGGHLKDEGSKLQVVTAGAIAGLVSRFVVAPLDVVKIRLQLQPYSLSDPLAPLREAPAYRGTVHTIKHILKHEGITGLWKGNVPAELMYVCYSAVQFTAYRSTTVFLQTALPGNRRLPDSAETFVAGAVSGAAATSATYPLDLLRTRFAAQGRQRVYSSLRGALRDIRRDEGVRGFFRGLAPALGQIVPFMGIFFASRYVYSDIPVYTSAVRALRAIYATEGLRGLYKGLPISLIKAAPASTVTLWTYERSLKLMMSWDENEGEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3G1</accession>
    <name>A0A2T4C3G1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1246084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3G1"/>
    <dbReference type="STRING" id="983965.A0A2T4C3G1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="17516" checksum="693B390790573C6D" modified="2018-07-18" version="1">MGKSTKVKESKKVVAAEPVKAAVASKGKSAAKKVVKEEPSKKSKKAEPESSDESSSEEEEDSDSASESDSDSASSEEEAPKKPAKKEAKKPAAKKEESESESESESESDSDDSESDEEETKKPAVNGKAKAESESESESDSDEESDEEEKPAAKVSQSHTCIHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3I7</accession>
    <name>A0A2T4C3I7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1401555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3I7"/>
    <dbReference type="STRING" id="983965.A0A2T4C3I7"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="389" mass="41961" checksum="691F373CA090B87E" modified="2018-07-18" version="1">MPIAPIITFKAGQCDVDTSSKPYKVTPLPEPGYIYLYSEDDLVHFCWRRRNQPLDDPELDLVMVPTDGSFLPYDSKTSPQPTAKTNGRIFVLKFASSSQRHLFWLQSKPQGRNGDPSYFSPRDRKIGDIVHRLLQGEEVNVTRELAAVRNNNDRQDDDETMEDIEGHGHGDHHAGGSGGAGPDATGGDIREEGEGAREGGADGARAASSSNPDAAAAVRNFLDSLRGQPGLAGNQQQQQQQQADIAYPYLNHLLPTSITVPLVDSLSAEQVDSLLSFLPPAVIVLASGTAELDGTADPTAAQIQAANEALSFEKKQALLKKVLRSPQFHQALGTLTMALRDGGLPSIADALQVKVENDGYLQPGIPMGGGYAVKAFIDGVKKTVKDRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3X2</accession>
    <name>A0A2T4C3X2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1401712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3X2"/>
    <dbReference type="STRING" id="983965.A0A2T4C3X2"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="513" mass="55564" checksum="422A7E8481A86BFB" modified="2018-07-18" version="1">MEAVELLLAAGADPLLVSLGEENLTAIGFAAQKGHRDIIKRLWTFCPPEAHLNPGRRHVTCFLVAALHGHAAVVEDLLDWWDGWPHDQRYRALLGAAHRWRFGVVTLLLDRTSFEISILQEALQVATDSRRLMSDGDDGKCDGIDFLNQQRVVELLIDAGADPNACPNNTPLLYTVSHDANLTGVLKSLLEKGADPNKTNGSGKSALHVVAEAVIIGRPIHIIGRPEPTMMNETAIRLLLQHGASVTQPDNAGECPLHWAAYGLDLRLFRLYHSSCPEIGRDALLQVTNNYGETLLHFAAAGCRMEVMEFLISQGLDVNARNANGWTPLMCALVPIKSRFGRVKSTGEAIQAARSLLSHGANACIVTDEGWTPLHALSLHGDYDATGKMADSARDLLSRGISPESPARMLIPDSRTVVPSLGLPWGHRLRDVMADPSAQRLEVLPAMSPLYWAATRGAVGVVRALLAHGVDLSPMDEDGISPTRMAAESRFLERQPGLADTIVELLLAAGAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4M3</accession>
    <name>A0A2T4C4M3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1332959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4M3"/>
    <dbReference type="STRING" id="983965.A0A2T4C4M3"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="852" mass="93452" checksum="112206044286E334" modified="2018-07-18" version="1">MSFFGFDTSGRHNAAAPGFSQPRDPFAGLSGHQEEGDALDFEDTYDGLGDQLDDADDAFNDDTFGGDTLGAGDSAAGKVGKDFDFFGQTAKVADAIEEEHLRFNRLQPAARSNAAQTQAQAHSQAQPSGISQQYAQQQYAQQQYSQQQYSQQQPYYGEPVATRPARTGYEKYNEPDALPDLHVDQSIWGIGPPKAAAPAPKAAPQPAPSSSVGRKVMSLEEVEAAMRAQAKPSPQPPVSELASHQQAPAGYPAVQHASPLPQHGQPHPVAILQRPQGSQAKASPSLAPKLPTPHGQQEQYHNLHQQPAHPVHPVQILQNPKRLSSEAARAAAGTQEPPQTAASAAKLAQMSAHPQLAHMSEEEKVAFLDQETKRAKRNHKIWLLSKDNGVMTPQDKNFITRIQLQQLVSATGNPVEQGSDASLSEDFYYQVYSHIRAGQRQNPSQPLSNFAQTYLFQTGGRHGNMRRHGRPAENHIQRMEQQVQRAVEAAKNKPKNPQLVIAGSLGKISFSNAKTPKPLLNIKRAAENEPHHHRAGSGKKSPASSLDRKTILRNAELVYVTLMKIEDHVRVMPPPVTDQADQELQEKHKEWAATLEALNARLWQELKVHEPIGVIVPHPFIAFLSCAKGKKAIPRIFPHLSFEQRTTIMTMIVYHLDQLDVVNGAAVTNDETVPNARMRENIDLFLSTVMPSLMQYFNDTGLDIVDGVLNLIATNLNVDLIAKTRVGVSMLTLILSRAVLLKQTGGGTPEQWAKWDQTYETFFSRLEVSLPYMFPGSINTGSDVYVWQLLAALGVSASNDQQTRLVLAVKDRVIGTISLAKTLPPTMAAERLSSVNLFLHSIGLDVDMLMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4V5</accession>
    <name>A0A2T4C4V5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAICAR synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_66293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4V5"/>
    <dbReference type="STRING" id="983965.A0A2T4C4V5"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF126">
        <property type="entry name" value="PIPK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="42979" checksum="BADE0672B18D1227" modified="2018-07-18" version="1">MRSRTRRISTRITHAILEGNDAETGQKRQSACVQLPRSMVNFFSLWRLELMLLRSNEFLALRRGVWHLDDDAYEQSFRTQHDNPPHTSEDERPAPSLVPLGNLGYSGSTFFKTSDGKFLIKSLDRHFEHQFFMHELLTPYIIHMWENPDSLLVRVTDLLCVPYPTLGGLLGIEPTHHVVMENLLYGLDVDSDTARYETYDLKPNDYFFPERDIANGRLAPQSVKDRLVDRFPDRIRVSQQATEELLALLSTDTEFLADSNVLDYSFFLVRYARSRESHFDVFNPFSTQTSSAERQTNSWRTGVVSSDGQWVYRAILLDFFWARHKLRAKAMAGLVATFNTWAGYGPMTITTEPSEYRARFMRMVKKLVAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4W5</accession>
    <name>A0A2T4C4W5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endoglucanase EG-II</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1439221</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Endoglucanase (EG) that cleaves the internal beta-1,4-glucosidic bonds in cellulose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with EGs, which cut internal glycosidic linkages to reduce the polymerization degree of the substrate and creates new chain ends for exocellobiohydrolases (CBHs). The CBH release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4W5"/>
    <dbReference type="STRING" id="983965.A0A2T4C4W5"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000124">
        <property type="entry name" value="Exported cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015680767" description="Endoglucanase EG-II" evidence="18">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="19">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB76572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="418" mass="44212" checksum="DB7B21E138A80EF7" modified="2018-07-18" version="1">MTRSMAPLLLAASTLVGGVAAQQTVWGQCGGIGWSGPTNCAPGSACSTLNSYYAQCIPGATSITTSTRPPSGPTTTTRATSTTSSTPPTSSGDRFVGVNVAGFDFGCSTDGTCVTSKVYPPLKNFTGSNNYPDGIGQMQHFVNDDGMTIFRLPVGWQYLVNNNLGGALDPTSISKYDQLVQGCLSLGVYCIVDIHNYARWNGGIIGQGGPTNAQFTSLWSQLASKYASQSRVWFGIMNEPHDVNINTWAATVQEVVTAIRNAGATSQYISLPGNDWQSAAAFISDGSAAALSQVTNPDGSTTNLIFDVHKYLDSDNSGTHAECTTNNIDGAFAPLATWLRQNNRQAILTETGGGNVQSCIQYLCQQVQYLNQNSDVYLGYVGWGAGSFDNTYVLTETPTGSGNSWTDTSLVSSCLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C579</accession>
    <name>A0A2T4C579_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1231772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C579"/>
    <dbReference type="STRING" id="983965.A0A2T4C579"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="392"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="503" mass="54975" checksum="2B76ACAA812B6222" modified="2018-07-18" version="1">MAQALDCSSSSGPGTLVALPERTLGLSASAITPPSTVQRSTWTSSPRAPAMDMFTFTTAAPASAVASYAPAGGSNSNSNSNSNRNSGGNSLGDVNFSQMPQFSGRNPLQSMKEGPDAKRIKVESPHSALDSIDSWLQFDEDADKFGSFEIDFSKQYNTANQPRASTNMTPGLGSGLYANPTAPFREEDFLDDSAFDHSLSEDDEMFDNININDQLSKLGTLPSTEAQSSRSIFSTPSLGWEKPQQGVQPSAVMGDEIPRRTTNDSWDPIPQGTNYTLTPDERRRLLEIAMGPGRLASYVNPNRFNMGFGSTMQPSIGQEFGFGFGAPKQGLSHMGMYQRNNSADTSASPLSQNRELKHKQPKVETPPRTVPTKRPSTLSDTSSLGKEKVKSADRMAHNDVERKYRTNLKDKITELRNSVPALQQVAEGEPDAAQGIAKVSKGTVLTKATEYIHQLEQRNKDIMTEHKQLMRRLQAFEALLNNSMRVDIMPSHSMTLFDPRGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5B1</accession>
    <name>A0A2T4C5B1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1752-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1391294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5B1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5B1"/>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3295" evidence="2">
        <location>
            <begin position="35"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="268" mass="29769" checksum="CDCECD3732781397" modified="2018-07-18" version="1">MPYRLDTHVLTVDANVIHKVDTGNPANLNNITHHLDAESAIDSDTEGEYVDESAIDDDDDSSDWEDSIDESGKPSVDEKFFQRVPSKANLTSRPSLITLMLAQNERAQNLGNQASQSTSALSRSRSVMNGPSMAGSPNDSDDGPLMMKGMRQSTLKPINEIPRSTAQPIAATANHVHAQAALSPRTTRRNMLATELTESLRRHLLWERQQKSSTANAVLKRRHTSHDVANLKQYPERSCIKQSEDVNASSWNQYFTKEANNGYHSKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5F9</accession>
    <name>A0A2T4C5F9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5F9"/>
    <dbReference type="STRING" id="983965.A0A2T4C5F9"/>
    <dbReference type="OrthoDB" id="5331891at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="525" mass="59096" checksum="14421A75D3644AEB" modified="2018-07-18" version="1">MKDPAHDHWKATSLERKLEAVLGRNMASLTDIVNDIAESMAALQRAFHCFTPLEEEQKRRRPLKDSIRKLRKRVTITFEKKSFEDQIDHLERSNSGLRRLREQVSQLQRHSRYTARRTSARGGRLPREFGAYGAVRRASKALHEALKTAWSSTQAPHLGHFVRLFLNAKAEADVQMEIAILCYGAEWPQRALLQTTMTRLEVRSRTKDSIAWSSAGLLTPAAEADSSQNDRQKRRRVRFSSIGDAPTESTVLSTDDLQLTGHFCRELSRRCSASGFMCKTEGLGHLDSCVQEGFRHCFFPCSSSCGNNIALDNVMLMDEALGQSASTRLTVVGQLQLAHRLVSAVLKFNSTPWLNEAWSVRDLAFFRQGEDLTMYLQTLHFGVELIQSKPEPADSMSPMDVESPANLSQSFEDAQYKHGVRNITLYSLGAALLAIGRWERIDHNDIEGVRRLASQPCYLGPVYQELTQKVLDCDFGYGKDLKKPRLQEAIYEMVVLELESMIATLDISDDEVYIETSGTMSGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5K2</accession>
    <name>A0A2T4C5K2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1438586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5K2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5K2"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="588" mass="63393" checksum="5E3B98E0CBD2BC86" modified="2018-07-18" version="1">MGSRPGSSSGSPPGSAPGPGSAQSVQPPTKPCHNCRRQRLRCDRSYPHCNKCAAAGKECLGYGKLFRWTGAVASRGKLAGRTSSAPLQAGAAQEAEAEAGAGSGSEGSGVKDTVTSPSLTCRRPSSAVSVTPGSPGSPAWPVSPRRPATALALGRPFTPASPTGFLSHPTSPIASPSIYRTPVDPLFQDVNPSHRFYLDYFTNRVCKDLVSNDMLGFNPFRSLIPLTGAHPLLQHIIVAASAAHMSNLISMGLPFPDDGGFIPANRPAASAKALNDALVAKHTALKLMSAAIQNLHAVDGDVVLAASLFFINVELIESGKHGWRAHLEGAAKIMSSLQLTQAWDSSLRDYLLSDCFIYFILASAFMPTRYATSLKFESSQIPFVLGKTVANSYLCCPPELMEILHAASQLSSELVHDQTSEDVTTAAIALINRAQAYDIYSWARDTSGVLELPKDVMKSRMHAGASHRLAACIYILQAIPSAGERLGSAFAAFLVDDLMAHLNMMPVEDPNFKATTWPTFIIGAETREPERQKFVMERLRIMTTVCPWGFIHTAMETLQVIWNLPDEERGSKTWVQMLKDPEMNFLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5M4</accession>
    <name>A0A2T4C5M4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1332320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5M4"/>
    <dbReference type="STRING" id="983965.A0A2T4C5M4"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF91">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="256"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="749" mass="83411" checksum="C184AC5B42252C19" modified="2018-07-18" version="1">MAVTAALRPHPLAPLSPAEHIKARDAVAKLHGPSESIFFRAIHVQEPKKAELQPFLEAEHTGKLTDETKRPDRVAIVEHDVIRADRSEYINAFVNLETGEVATVSAPVPHQPYVTPGEFDHFNDACINSDLFKEAMSEFVLPEGFEICIDPWPYGPPNADEKDIPRYMQGLVFAKDTRSGNEDSNHYGYPIPIVPVMDWHTKKLIRVERIATGGIDDELDAKIRSEEPVKLFENHKGCEYVPELLDMPLRTDLKPINIIQPEGASFTIQEDGLIEWQKWRFRLGFTPREGAVLHDVHYDNRSVMYRVSFSEMTVPYADPRPPFHRKQAFDFGDGGMGRAANNLELGCDCLGAIHYVDALTTEPDGAPSPAKAVVCLHEQDNGILWKHTNFRTNRAVVTRNREFVVQFIATLANYEYVLAYKLDLAGSITLETRATGIVSVTSIDEGKVSAYGNIMTPGVLAQNHQHVFAVRIDPAIDSYNDADSQVVIEESHGQKIDPKTNPYGNFYKVQREKVEQATWIDAEPRLNRLLKLENAHKKNPISGKNLAYKLVAPVTQMLLADPEGLAAQRAQFAQHNAWVTGYRDGELWAAGEFTNQSTREVGGVADMVKRGDWFTDRDANGDAEEGQGKRSSPVVWSVFGLTHNPRVEDWPVMPVETFQIHIRPTDFFNVNPAIDVPSNRNDASVLLGGSCCTASSDKNTSAVQQHPVTHLQGSAPSIDPKAVGANVDDKLSKRLSKTFNGLFAKKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5P5</accession>
    <name>A0A2T4C5P5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5P5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="57" mass="6407" checksum="43C907680ED924E8" modified="2018-07-18" version="1">MHTHIPPQSPKIKVNLTQPASHRTTQHPSHPPSDRTQHLSPKYILTTAAYPLPHGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6E7</accession>
    <name>A0A2T4C6E7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M440DRAFT_1437739</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6E7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6E7"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="84"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="507"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="840"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PTB77141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1058" mass="118547" checksum="D05DEE7730A62C73" modified="2018-07-18" version="1">MSADFWAGYLSGIIGIIVGNPLDIEKVRRQTRSHVAEKLYSQSSVAFMKGTAAPIFGYGALNALLFFSYNRSEAMLKGSASTPTAGWVTWTAGAVSGLAVWVVSAPTELIKCRAQMSTPAMSSWAICKQILQRDGVRGLYHGGVVTALRDSIGYGFYFWTYELAHRHWPAAREHDDAVPGRRDTSKVLLCGGIAGIATWASVFPLDVIKSRLQTQQQQQHLHRATTDMAGNRRYGAWQMAKDTYRDGGMRPFFRGLTVCSVRAFVVNAIQWAVYEWIMSEVAIGNEPLKDGTPGRLNRQASRPQNLDTLRKPFKCPSSATAASTSDRPARKKRKVDYRGADDNGPPATDAAYDGSGRQVQPMPRFPVFQAKDKSVVFRKAFSVPLKDKSQATYDASRPPPTLGLRRGVVFVPKPLHDPSGEFAIVLYDPTVDAKPVAAEEKAVQTQAETSKVDSPIMHKSLAEILGIKKQVEEDHPKVPVVIDPKIAKCLRPHQIEGVKFMYKCVTGLVDEKAHGCIMADEMGLGKTLQCITLMWTLLKQSPDAGKSTIQKAIVVCPASLVKNWANELTKWLGPNAINPFAIDGKAPKEELKRQLRQWAIASGRSITRPVIIVSYETLRLNVEELKHTKIGLLFCDEGHRLKNADSNTFNALNDLNVSRRVILTGTPIQNDLTEYFALTSFANPDLLGSRLEFRKRFEIPILRGRDADATEEERKRGDECTGELLGVVNKFLIRRTNDILSKYLPVKYEHVVFCNLAPFQIDLYNYFITSPDIQALLRGKGSQPLKAINILKKLCNHPDLLNLSDDLPGSEKCFPDDYVPKEARGRDRDIKPWYSGKMQVLDRMLAKIREDTNDKIVLISNYTSTLDLFERLCRDRHYGCLRLDGTMNVNKRQKLVDRFNDPNGDEFIFLLSSKAGGCGINLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATGTIEEKIFQRQSHKQNVERHFSLDNTTSDTHDTFKCKRCKPDGRQFVKSPAMLYGDTSTWNHFVNAGLQPIQDLLLRQEHGGSEVSAVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7F2</accession>
    <name>A0A2T4C7F2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1329985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7F2"/>
    <dbReference type="OrthoDB" id="4892176at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="237" mass="24724" checksum="D682B7AC51027F05" modified="2018-07-18" version="1">MPRKGYDVTGSVPGSAAYEAAARAKQRNAPRSRTPRAGTPANPSQPSGDDQETPRASRTGIFAGSAPVDPSMYSQMNAIQGNVGFPSQQRFPGEQLYQNPLNTSSMQAASQSAAPLMGAPYGHGAPLGAQSSMFPGAAAPSFTGQFVNVPERFRDATFGTVGSGAQQQLWNSNQFHALPASQHGIQSRPIAYPNQQSLSHGQADTGAAFHPAPSSTNMGTLASQAAQEDTEMTDAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7I9</accession>
    <name>A0A2T4C7I9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN2</name>
        <name evidence="13" type="ORF">M440DRAFT_1353662</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7I9"/>
    <dbReference type="STRING" id="983965.A0A2T4C7I9"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02672">
        <property type="entry name" value="Peptidase_C19P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="484"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1100"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="879"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="986"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1039"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB77530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125948" checksum="7CE78910A54CF95C" modified="2018-07-18" version="1">MEGWDEIARVQLPPPAVHALPTRVTTMVFDTVQPLLWAGNEFGRVTSFVGNDLQQHTSFKAHQASDGPVRQILVNSKGVLVLGATDVHMAQRGGPPIWHLRHEEMKQLRCMTFTSKGTAEILVAGLQKTMLVIDVSKGEVVKQVPTERQYSIMRRGRYICAATENGAVDLLDPVTFALVKTWHAHTAMINDMDAQHDFIVTCGYSLRQGQKYMLDPFLNVFNIRTMSSMPAIPFPAGAAYVRMHPRMLTTSIVVSQTGQMHVVDLMNPNTSNVRQANVMSYLGMFEIAPSGEAMALADAECFIHLWGSPTKIRFVDLPAHIEYPHIEAPAPPLEWSSDTPLNSVGLPYYREVLASSWPELPSDVGAPPVKFDAQFLASLNSTESALYGRNTRGLKRNQVEDTRSIHKSAKSGIKAPKFLSEQARDLAKSESSSAGERADELSFPLSEMNVGSDMPMMYRNVEIKYSKFGVDDFDFGYYNQTRYSGLEIHISNSYANSLLQLMHFVPLIRNIALKHTATACISETCLLCELGFLFDMLQKAEGSICQATNMLKTLSRHPQAGPLGLLEEEDAHASSLHAMLQGLNRFLLDRIAADYATMASVPTPVEETLATMATSNIKCATCKGEWKRPGSTYVNDLLYPTTRPPGRNGRTPRTTFSQILKSSVERETTQKGWCIGCHKYQPMSTRKTIHSVPKVLMLNTAITTADHRSLWSTPGWLPEEIGIIVEQGQFFCYEGEDLKLHLQRGIHNITVYSLIGMAINIESGQAQKPHLVAMVNVGHAEAETPAQSQWHLFNDFLVRPVSRDEALSFNTTWKYPSVLAYQVKAANNKIDHEWKKNIDTSILYQDLGPSPRAETKTYQLLDPATERPGPGTIIALDAEFVEVRQPEIEMNSDGEREVIRPRVHALARASVVRGQGEKEGVPFIDDYISINEPVVDYLTSFSGVVAEDLNPATTTHSLLPHKVVYKKLWILLNLGCTFLGHGLKQDFRVINIHIPKAQIIDTIEKFYLKSRLRKLSLAFLAWYLLKEDIQMETHDSIEDSRTALKLYKKYLEFQDAGILETMLQDIYRAGRDVNFKPPKRDGGDASRSVTPPALPAAENGGTPTPTQVPTTPGRVGFNNGGWTPGKASPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7L1</accession>
    <name>A0A2T4C7L1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7L1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7L1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="157"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="751" mass="86269" checksum="5F3C6F1B2CD8CCCE" modified="2018-07-18" version="1">MSTYDGSRSARQSKRYSMSALYMSMSANEGEMQIEDDLAKAQKALRDLKSKISSQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHLDDSEMEQGFFPNDDKTQKYGNLLFLLQSEPRHIAHLCRLVSMSEIDSLLQTVMFTIYGNQYESREEHLLLTMFQSVLTYQFDNTPDYSSLLRANTPVSRMMTTYTRRGPGQSFLKIALADRINSLIELRDLDLEINPLKVYERMVEQIEEDTGTLPPNLPKGITAEQAAENPQVQAIIEPRLTMLIEIANGFLSTIIDGLEEAPYGIRWICKQIRSLTKRKYPDANDQIICTLIGGFFFLRFINPAIVTPKSYMLIDGTPAERPRRTLTLIAKMLQNLANKPSYSKEPYMAKLQPFIQQNKDRINKFMLDLCEVGDFYESLEMDNYVALSKKDLELEITLNEIYAMHALIEKHRGELCKDETSHLAIIVSELAAAPPQVPRKENRVINLPLFSRWETAIDDLTAALDITQEEVFFMEAKSIFVQIMRTIPSNSAVSKRPLRLERVADAAATSRNDAVMVRKGIRAMELLSQLQELGVIDKADQFDLLRDEVEQELQHLGSLKDGVIAETEKLEEVFKTIRDHNAYLVGQLDTYKSYLHNVRSQSEGTKRKQQKQQVLGPYKFTHQQLEKEGVIQKSNVPDNRRANIYFNFTSPLPGTFVISLHYKGRNRGLLELDLKLDDLLEMQKDNQDELDLEYVQFNVPKVLALLNKRFARKKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8B2</accession>
    <name>A0A2T4C8B2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1375356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8B2"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="621" mass="68084" checksum="A44F0D0014D2D90E" modified="2018-07-18" version="1">MNRPSLANLPDDLILDIVQHLDTARDVAHLGGISRHAHAVINQSGWRSFARAKFPSIDAPAGLLGGWNAVADRLTYLDRCWDTRAFYLTVYAEKAAPARPKRRDFARNRQSVNFHSVIDAATLLSTQEELLAYGAGENLVLGRKGVCGKDQSRWSKLGGRETGYAAGTGDVTAISIIERQQFPEVVVGRADGDLQLLSVGDETLSEAPQSFASIHDSADAAKAPLTRRSPGQRAVSWTEWQPEAKLLASCRSSVLTLYNLSDAEEAALKPVLFYDVSKDSSADEVSLLRSVKFMGQDVLACGIGGSSEPLRWAKIRPTGIEFTHAAKSVRLSEDGGFAESGRLAEKTTVRAIQPVSRMNQNLLLSAWDDGSHRLSDLRTPSNHDVLYRDGFQPYQGSSSLLVYGSERFVAGNNCSPDLRFFDFRFPKAYHHTSALPCSAHAPFPGRPYQYGAVNDLDGLQLAPVDTCDSASGRTCTWHHLSRQDNWRPDAVMHIYSSSMDRVHCLAKASDLSTSFYCGVRGALVEATYALAEDGDAVASRRSAPEGWQAGDPEGRASLIETGVGRRDGESQLDEQTQTRMPELYYYERWTIPETDGLEGTGMKREAGRRLDPALVASRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8C5</accession>
    <name>A0A2T4C8C5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLM1/RGC1-like BAR-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_3957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8C5"/>
    <dbReference type="STRING" id="983965.A0A2T4C8C5"/>
    <dbReference type="OrthoDB" id="2264563at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLM1/RGC1-like BAR-like" evidence="2">
        <location>
            <begin position="90"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="444" mass="47816" checksum="999ACAC86794B9DC" modified="2018-07-18" version="1">MSQPSPPNSTLPSRATTGLSEDAIPEADPSTTAGLLAERLQAWKHMVGYLEDYVEAVEKVHGRQAKEYEKVLKTISNPLREGHHFDQSLGGIAGFFENMRANTQAMVNTNIETEKSIKGSVLPILDRLHKEIKHKAKELASGAQAGAKEVDKLRNVTQKHIELLGQQAAAFESHGGKMNSHDDPYVVRRGVLHRLNNQVIAENNHHNDLVAVQNNFRNFESHILEVVQQAIEGFTQLAGGQGEKMRALHSDILGTVQCIPRDFEWTNFQHRAADRLVSANDPPRSVEAIQFPNMEHASTKALIEGSLERKSRNKLSFGFSTGYGVPTGDKFTIKGKDKSGTLSSKLTGSSEITFKAHTPADAQRWFQVIQGVTNAAPPVATAAAAGGTNSSTPTSPVGTSSSPETTTLPVGQGRPAEGEAKAPVDKHQAQEAGVTGGEANPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8I6</accession>
    <name>A0A2T4C8I6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1455945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Virilizer"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
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    </dbReference>
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            <end position="21"/>
        </location>
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        </location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB77909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A2T4C8W7</accession>
    <name>A0A2T4C8W7_TRILO</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="5 6">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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            <end position="148"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="250"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB77984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A2T4C9A8</accession>
    <name>A0A2T4C9A8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9A8"/>
    <dbReference type="OrthoDB" id="10404851at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015766297" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8975" checksum="F634422356A46E3B" modified="2018-07-18" version="1">MLSLILVFFYLFFVAIFGAHALPAGSHHFKRHEHILTRVHNLRLSRLTSTYYDNSDESFRSSRQWSENQLEEGLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA52</accession>
    <name>A0A2T4CA52_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1329501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA52"/>
    <dbReference type="STRING" id="983965.A0A2T4CA52"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="159"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="582"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="723" mass="78721" checksum="A654D1EA9717BDD7" modified="2018-07-18" version="1">MNSRQRGFDTFYDDQVAARRQFYANRETAVNRINDVAVLVTVAALAVTLLAKFYSPDGSLEGIFSLLSNFVWDALVFVTPAPLLFALDDWMDSSTTTRPMRETTTTNQSNHAAKSVAMRRVMGLDRQDGVMNSVLRARTRALSMTGSVLGLKTDSDRPAGLGNRDNSCYQNSVLQGLASLQSMPAYLSACLKGLEEAGHGADGNVAHTLRALIADLNDASNNGKTLWTPSVLKSMNTWTQQDAQEYYSKVLDDIEKAAALAAKKLSSAKLAGLDSGEFSSTDEGSTSEHSDDSGYQSQSSSSRADSLKIMRNPLEGLLAQRVACVQCGYTEGLSMIPFNCLTLSLGLDKNHHDLYERLDAYSKLEAIEGVECPKCTLLKAQRLLTKLVERIRAEGATDDKLAEPLRRLEAVQQALEEDQFDEETIKERCKIPAQSRVNVTKTKQMVVARPPQSLAVHVNRSVFDPSTFNMIKNSAPVSFPMTLDLGPWCLGSAGSVKSTNEDAVDEKKGRDVEERWQLHPMSSMVAGDMGESRLTGPIYELRAVVTHYGRHENGHYICYRKYPPLKTQSAGHADDKAVALPERLADDKSAEPSEDETTPTDEKPSYTDRDSTWWRLSDHNVSPVNEETVMSLSPGVFMLFYECVDASMILHCEEEKEAADSANSALPVTAKHDEGRAQNGAPTASSGTGRGDIFSPTAVALGAKQSGPASGGTPEAEATALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAT1</accession>
    <name>A0A2T4CAT1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-terminal binuclear Zn cluster-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1328625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAT1"/>
    <dbReference type="STRING" id="983965.A0A2T4CAT1"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="192"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="596" mass="67864" checksum="2BED2AC8218ADEF8" modified="2018-07-18" version="1">MVKEDGNVRFMDSYIWASVYDELQKMRDIVETDDPEETSLLGSDELTPDNNADLVLSADVLNMHIDDLQPDPIHIFRLWQLYLDRVNPIFKVIHVPSLQPLIMEAATNMSALPLHQQALLFSIFAMASLSMTSAENIQTLGMSREAAMQRFNTGTKACLIKYSFLKNYNMTTLQALVLYLISLEGRYDRHAQWVISGVIMRIAQKMGYHRDGSQLNLTPFETEMRRRIWWQIMMLDAKCAMMSGLSQSWMNHNWDTRKPLNLNDADLFPGSTEPVVERDGPTEMAFSIVIAEIFRFKMETDGSNESRAFEAAIMGQTLDDTADPENNTKAIFEKFREKAKKLEERLLEIEKNMIDVRAGNAHVAALAIRPMLTHRLSEMLVPIQEQPEWGTEIFGPKDNFFKVLLMMMEHKMEAHEQMVAAGFQWFMRFHFQLDAFAVFTGLLHDRPIGTLADRAWEVMRKVYANHQELSDMTIKPHAAQAQFVLKAWRARELAYAQNGQVIDTPSFINRLRELVPSSDSRSSGQASVTSPATTLTPQQQPLMGFNQFLGGYLDVSTVNWDMFGELLPNSGEQLSASMFDGYTMGNLDMGNMGNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBJ2</accession>
    <name>A0A2T4CBJ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1398196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CBJ2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="932"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1112"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="277"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="611"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="892"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1208"/>
            <end position="1455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB78926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1455" mass="160967" checksum="6632A3B1804152D9" modified="2018-07-18" version="1">MANDCDDSFGPFATNCTAHRFDFTLKFEQSILTIGPCALFLTCAIARLGLLLRESPKVKRQSWYHAKTVAYACFIALQLTSLVLWSKKTRLSGLVSVAAAIFTFVDSIALAVLGVLEFSRSVRPPTIILVYLVFSTAFDSAQCRTLWLIGERVAASVYTAGLAAKLLILLLELQEKRSFLLPPWDRLNPESTGSIINRSLFWWLNRLLIRGFRATLSGQSLYDTDAALKSRRLLSKIQDARRSWATPKFRLMQRHGLLFALLDSIRQSLILAALPRIFCIGFKFAQPFLLKRVVNYVANEKNHDPEKSTGFALVGATALVYISLAISKGFYQHQLFRSLTMVRGALVSLVYSHTLSAPAISSSADATPRAPNSASLTLIGPDAAAITSALEAIHEIWANPIEIILAIWLLSRELGPGSVGPVFAVIVCSFSMSRLSKKMGPAMKDWTVAIQARISLTSRVLTHVQESKMLGTIPYWLDHISELRVFELHKSKKFRTFIAYMNMLGNAPTALSLIVTFGIALAVQSKSGDQLDLTTAFTSLSIIGLIVAPLSHLLYAVPLFASCLGSFDRINSFTDHNKSDQTKTLTRSDNPGELSDIGLSILSPRSGQHAIEATQVSFRVPGQNEPILKDLTFSVKHDSLTVVTGLIGSGKSMLLLGLLGELDTSGDLRLSSSSVSYCSQQTWLVKDSIKRNVVGPETSDVDEDWYKTVTKACALTRDIEMLPLKDLTNALNLSGGQKQRVALARALYARRRILIADDVFASLDPDTRHHVWSQVFGPAGLLRRIGCTTILATHLLEYAEDVDQIIILDQGRITHQGPSAVVQNAAIARKAVKTAETLGSSDFTECIEGENATITKPQPKDEDEQEAEDLATTSDSSLYLFYFQSIGLKFGLAVICLAIIPVFLSQFTQIWLKWWTESSTESSNNGMYYGVYTALLCVHILTIGIDCWFMFVNVIPRSAIWLHRKLLETTLRAPMLFFYRMDTGDLINRFTQDMTLVDRELPTAMYTTLSAFLACIGEFILIMIGSKYLAAALPVALIILYALQKFYLATSRQLRILDLQAKAPLYRQLLETIDGLATIRAFRWQNVMEQESLDLLDLSQRPHYLLLSVQRWLTLVLDLLVTASAVLLVLFAVITQSTSPGYLAVAMYTVIGFSESLSNLLMSWTALETSLGAISRLKIFVKTTPQESEPLLKDQVHPPRSWPSVGEISLQGVQARYNLTEQDSSTPPVLDVVSLKISSGQKVAICGRTGSGKSSLIATLLKMVDYTGTIRIDDVDIANISTGELRSRLNVISQRPVLFPGTFRSNLILPNQQTTSSNAAARRLPPTDKEIINVLERLSLWETIQKFGTLDTDVGNISLSLGQQQLVCLARAILRKSESRILILDEAMSAVDSETERMMVEALEREFAEHTVLSVVHRLDTIRNYDTLLVLDMGKIVKFGSPKDLIDEGGRLVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBM0</accession>
    <name>A0A2T4CBM0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_224857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBM0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="137" mass="15479" checksum="5C172DD836B6D4BF" modified="2018-07-18" version="1">MTPSPHTPPQTPLPSVKQNSEESLIIQYTPLQLPSSHPLDPERHDTTRHDTARHIITEQSQRHRTSPVTQNPTQYPSSRSTCSLAVANPKALFQASKTQAWRLSSRKPARIRNVSPLPRNTQVIEPRHTSKLARFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBS0</accession>
    <name>A0A2T4CBS0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1349339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBS0"/>
    <dbReference type="STRING" id="983965.A0A2T4CBS0"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="207" mass="23911" checksum="5F44FDA63EDFEDA8" modified="2018-07-18" version="1">MAAAEEEENQHSETLLWAIHMCFNSSLYADVRIRLGSVELPAHAIVLSAQSEYFKAALRSPMKEATEKKFEYSEGSMHAHWRVIEYMYRGEYSEDPAQPLLPLADDDELIKDIRVYQLADYFRVEGLREYAMNNFESKIKHLWVSESFVDCIREVYGATGLGYEIRKAILQVVCSHLGELWEKKAFRLLVREGGEFAMEIISGFINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC43</accession>
    <name>A0A2T4CC43_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen Asp f 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1325766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC43"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015462151" description="Allergen Asp f 4" evidence="1">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="28044" checksum="A523C3D64D8461A2" modified="2018-07-18" version="1">MKFSTTSVLLAAALGVSAHPSGHAHKRAHNSAVEARGDFVMANKPAEAAPTTTSAAPAASTTAAAAPSSTGSATVKPFCGGNSKRATAAEIAYKGNVGAGGSYGCNIMTVDESLVDEYQYTMVFENAGDDTTCFCWNKIGPDGGINGFFKGNQAITFDVAAGGKQVVAVDTNSQVGCACGSGGPELTPIGQFASTWVEADFGNMSNGGWSGADASSLVAAAAGMTIPGLKVCGTGAASGTCSTIFPGGKGDNAFTAGTEALDGLGLNLPPGKTSITVTIDYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCS9</accession>
    <name>A0A2T4CCS9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1166996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCS9"/>
    <dbReference type="STRING" id="983965.A0A2T4CCS9"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="224" mass="25013" checksum="7BADAFD937041FD6" modified="2018-07-18" version="1">MDQQKPPEFILDVFSDPRSVREVVKGILHTIFFNRFFPSLAPRTHEVLDVTLPYVNDNELETLIEQRAYALERQLDAERLSSSGGHAAGLGGGAAAKGDKMMSGGGGAAAGTADGGSGGRGQITVQFFERKRRKAWLTRGEEEVCWETWTIKVTVAEPRTENERAKVRRAMEQTLFTTAMKIVTFVNTHKDHIPPITTQGGNPFPYKINLESKETSWVSRIRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD14</accession>
    <name>A0A2T4CD14_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD14"/>
    <dbReference type="STRING" id="983965.A0A2T4CD14"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="22857" checksum="4A8585B19100E196" modified="2018-07-18" version="1">MPPNVAIIITSTRTPRVGPSIASLINTILTNHISKQSPSTPKATLSVVDLATFNLPIFDEPIVPANVPARGSFIHEHSKRWSAEIASHDAYILLVPEYNFGMAGSTKNAIDYLKNEWTGKPAAVISYGIAGGKTASEQVVTSLTGVGLRVSPTRPQLAFVGGAGPEAFLAVGEGKLGDESRREWEEKHGGEIVQCFEEMLEALKNPPVVEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD95</accession>
    <name>A0A2T4CD95_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1172143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD95"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="21076" checksum="CA5A92BCF8599AF9" modified="2018-07-18" version="1">MELFADVQYIGPDPWSSRLEQWHTLRWVLSCQCQPGLQMKDLTVNAAVCFDELLSSVCTSRVEWLLSRRVSNPSHYRSSIISTLPRQRPHQNPHARGNPRPTSGDPEALLHALGDPSCELPQSPETMNAHVSPSVVIQILESSTRDHQPLLHTYRSRSHSTETTSPLRKGPSVPPLLPPRREARPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDC6</accession>
    <name>A0A2T4CDC6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1325952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
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        </source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
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                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
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                <person name="Druzhinina I.S."/>
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        </source>
    </evidence>
    <sequence length="1062" mass="118862" checksum="38FA864160063E3B" modified="2018-07-18" version="1">MSSLWSSEKPAPESSSEAPSEAVEEAIESSPDESAIDDSADPSPAPQVPPLSTSRAASQQSQQQSQRQPNPPQGGNSTMPSAGNYNNYNNAGNRSQPPQHAPTDSLSLMQLRHIVARVNAADPAAYDFVYSDMGPHAEEIDEWFVYQFWQWVRLNAAQKAFEWHWKHESGGKHGWDDADHDTRARFVQGAIAGVQSNDAALRANSIGKIMYLVLGRWGDTAMPHATDENSRSIASIPQLQAMKAGVACLTSLGGIPVVWEALRNVFEIHWSGDIQQGNAQDAQDELMNLLTIMYIVVQETLHDPEDMASTEAKLLELNPSLVDFMMLATSKLRWDEQNTMPHTQIFLLFWKSILLVFGGLEDLKRVKEATSELTGGDKSKETITASPLDYHVFRQEITSKYPAYVPPQPLIPLEADNASLLPPLANMTSRTVANGIIPQPPNVQLGGASILNQPVHIATPAPSPPPSPGVGGKGGKKQNYQTNQNFPFMYPPLDATSNSAGGKGEAGYGNPLVSRKWEGSDIPASILEAGQIFSSRVRMTRATRQLWEERERFLKFERGWEADDDADEDDNDDIEDLDLNELTLEEKEVLRELKAEDKKEKKKKERSFPGPEVDFGPQPERLSERDKQRLIAVEKFYANALPHLQSIVIVLLRPILVNVTAIVAQQQNQMAGMTNRTGNPGANGHGSQRGMDMNAQGQQEQEGEPSPEEIDATRTREITSKAMTAILLLLLKWLRVSHVLKFEYLTQLLLDSNYLPLVLKLFAHQDIQQVVDSKMDHVENSFFQFCNIRSRFKDKTESEAGNEGGGDGAETGERGEGEGDNEQQPEGQDSEDDAAPPPIKRQREEEPEVDQMEDVAVDGLEDVRMRPEVDEMGVPLSNIPLEPITDFSRRNFFSLINYLRVMQKICKNKAHRNLLLVQYKSSTILKKSLRVPQPELRLYTLKLFKGQVPYCGRKWRQSNMRVITAVYLHCRPELRDEWLAGSDIDAEVDSALPLEQALRSLTHWLNVRRYPERIAADIRVAMREEHDFFTRELEKVDLNWSDLMVGGDDGMSEVDHGESTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDY3</accession>
    <name>A0A2T4CDY3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1179787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDY3"/>
    <dbReference type="STRING" id="983965.A0A2T4CDY3"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="4">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="23223" checksum="7E610958F2E470D3" modified="2018-07-18" version="1">MQGQVQRKVTFELGCWVLLYLEVETDTLRRIFRLFSESFSALPLATLIGSKYLVLHGGLFSDDKVTLDDIRKLNRHAQRQPGQAGLMMEMLWTDPQDEPGRGPSKRGVGMQFGPDVTKRFCENNGLEAVIRSHEVRMDGYEVQHDGKCITVFSAPRYCDSTENRGAYINIGPDYKLRFEQFDAVPHPNIRPMAYAQNSLMSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE40</accession>
    <name>A0A2T4CE40_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1317291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE40"/>
    <dbReference type="STRING" id="983965.A0A2T4CE40"/>
    <dbReference type="OrthoDB" id="5243355at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="216" mass="23766" checksum="0D7B8E46BCAE0DD3" modified="2018-07-18" version="1" fragment="single">YQTVQLLLDRGAAIEASNRWGRTALMEACNTPCVRLLLNRGAVIETRDDGGRTALMLAVRQRRENIVKELLSRGAAVHARDNKGRTALLFISPYIPSKSRAYRILRRFIDSGASIDERNNSGRSLLMEAAKNGLIDISSINALLCLGADIEARDNEGRTALMYAARYYRHGALRKLLDGGAALEAKDSLGKTALMHAAQRYGSDVLLELLDRNVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEC0</accession>
    <name>A0A2T4CEC0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1105914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEC0"/>
    <dbReference type="OrthoDB" id="5150675at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="9074" checksum="80A4B614A5164C6F" modified="2018-07-18" version="1">MASTATKQTPPSFVGTSKVVETSYPVCNWRSVGCAATRMNDSTDWDILAHRQRPVRFPSLISRDDFLWWCPRRLGNLGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEC2</accession>
    <name>A0A2T4CEC2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bys1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1105575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEC2"/>
    <dbReference type="STRING" id="983965.A0A2T4CEC2"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015693228" description="Bys1 family protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="15797" checksum="BC1AA6CD6B73AED8" modified="2018-07-18" version="1">MKFTTAAVLAIAALVESASALGKARVVNKCPFSVTLWSVGSAVSAPTTLAQGGSYGETFSRDPVTGGRAIKVTVQPDGLYTGKPQTIFATNLDGNTIWYDLSDVFGDAFNGHKVVVASANAACPQIVWTSGVPPAGSQVKNCGADKDVTLTLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CED4</accession>
    <name>A0A2T4CED4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_358153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CED4"/>
    <dbReference type="STRING" id="983965.A0A2T4CED4"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="21718" checksum="CBDA8816BB9FD869" modified="2018-07-18" version="1">MSRNLQTVSLLLAQEGILVDARSDTGLTPLSLAVSGGNAEIVRRLLAQGPLVNPDSRSDRGWSPLYIAIDHQVDAEIVKLLIDTARVDVNFIDPVSCSTPLIAAATNNLPDIAQLLVSHPDIDPNLGAHNNQIVPIATAAARGHTEIREEIVGMLLADERVGEESRQLLKGQRIFSRRPALGSYIENGLWWSKMFNSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEL3</accession>
    <name>A0A2T4CEL3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1323987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEL3"/>
    <dbReference type="STRING" id="983965.A0A2T4CEL3"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="146" mass="16484" checksum="0A3965AF70AB84B7" modified="2018-07-18" version="1">MASSDDKPETITGGCVCDSVRYTVTFPRDHDFANSCEQCRKNTGSLILRAHKVPKSAVDFTARSTLKLYSATPHFERGFCSNCGSLLFWQRDDRDYTHLMVGCFDSPVLARYGPLLTAARRHLFCEREVPGVTDHLVGDRFTRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CES3</accession>
    <name>A0A2T4CES3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1435784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CES3"/>
    <dbReference type="STRING" id="983965.A0A2T4CES3"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45643" checksum="FF8C7BD936554D67" modified="2018-07-18" version="1">MASSRARDLLQLTNTITGLPTLADAMDPSNFPFVEAARLAKPMNWGIIKLKNIPFSTTRAEVIAFLGRNSKVLNDTDEGVHIIMDKVTSKTMDAYVEFVSLEDAMRAVEKHRANVVAGRFSRLGDRPIEVEVTSQANLMRDLFPVARGVFWNGVTPEILPYNPTQPWDNFKGFVSEEEMIMLVKHVEVPHRSPFSRDCPQRPYECLISTIKKFPWFLTNCVTIKEREAMFQATIALIRQLTRNILLQEDAAHLTPFLLRRLVQAAMLCPGFTPCMKDGIAWLTNMQALDQEYYQLPRFADRWRHQYAIGPKPGFPQDVVEWYVTIIREQSQKDILTLPFRERAELQERANQTDMYWGYFWAEVGYGLGPQFDDMSLAQAAHMEFSAVERILTRALTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF60</accession>
    <name>A0A2T4CF60_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1435872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF60"/>
    <dbReference type="STRING" id="983965.A0A2T4CF60"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB80199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="37838" checksum="938CC85252505643" modified="2018-07-18" version="1">MADTEAGSAPVALFKKRGAKGKANLRKRPATPPPAANDSDSGSDFSSSEDEAGHRVKRRRKTAVVTAAARGAAPSNRDDDAPAFTADRSVPIADSNDATKHSNWYDENAKDALSAKNLLGSSRASKDAPPDGTYKGLANQTSFIQTNPDAPRKTVGPIKAPTNIRTVTITDYAPDTCKDYRITGYCGFGDNCKYLHAREDLKAGWQLDQEWEKVTKGKKNLGGTVVASANRNKAKEDAGGDDDDEEAILENIPFACIICKESYKEPIVTRCGHYFCLPCALQRYRRDPTCAACGSGTNGVFNSATRLKKLLEKKRERAARRRREAIERGEEVSDEEEEEEEEGGQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFB0</accession>
    <name>A0A2T4CFB0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_188478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFB0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="127" mass="14167" checksum="37DEDDC5AD9A429B" modified="2018-07-18" version="1">MVECSVQARRGLEMGSRYYRQKALPPSFDLRGFWDDLWHSVLPRPCSNCLPRPATGGHQTLRSFRKVWLFATPSVAQEEQVIARLAPAQPTKPQSSVSKPKPRKPSKPSQASPSSCGTQQRWLAHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFM5</accession>
    <name>A0A2T4CFM5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_191905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFM5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="130" mass="14668" checksum="A2F8FDEA743319C7" modified="2018-07-18" version="1">MTVLECRVGFQWQADSLSLRFMNEWKEDSPEEERCSTLADILPGHILRLCLSECMSLPGHLSALNSLYHLSPWTPFLFLSLSLSLSLFSILLIQPLISSVTTVLIIAFEYLMVLLLLSCEVSTFCARQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG11</accession>
    <name>A0A2T4CG11_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG11"/>
    <dbReference type="STRING" id="983965.A0A2T4CG11"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32671" checksum="61E455830B63343C" modified="2018-07-18" version="1">MRLYLLPVSTRRTLLYAHRVNTGSTAAHDGSLIDRGAAFAARKWAQWEKMERGWQRKVVDYGNQAFRRIPFEEWGLKSVPPLSARRREDELRGRDPVLLVFPPAAIPEHKAEGVVGRLATERQALHRQRLLWCLVGMPITAPLGLVPLVPNIPFFYLVYRAWSHWRAINGGKHIQWLLQNKLLQLAPSKELDQLYTRDGQDPDFEPSGKEQMLITQKQIRDFSSTLDLPAVEIELERAIWQVERALGKDEEQQQQQQQQQQAQQGEKATDVEGEEKKQKDKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG55</accession>
    <name>A0A2T4CG55_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1324659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG55"/>
    <dbReference type="STRING" id="983965.A0A2T4CG55"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000468">
        <property type="entry name" value="Related to single-stranded DNA-binding protein MSSP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000323">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="239"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="327"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="542" mass="58966" checksum="6C6F5B761CAFDA04" modified="2018-07-18" version="1">MEANSGVANPYYTGRGAHGATDFGALINQFNGVTLGGLSMPNNAAPVPMGPGHAFMVNSDSQFVLTPVPTAQPMGLGHSSENPYLNYPAAAGGYGGSYVGLSMPLLPFTPGRPGTTQPRVDRGHSDVPDLENRRGSYSTTESAPATPYYGGAFSIVRDYPPPRVASLDRSSYTTPSPNATGLAPMENTKPIPMVISDRTIDELLKKDPAIPKAVPAVFTPPGQMKTLEQSLENRIPGNRNVYIRGLHPTTDDELLYQFTSRFGAVETSKAIIDTNTGACKGFGFAKFYDVRDSELCIRAFHRLGYEIGFARESFNSRLKAEGDEGSTNLYISNLPKSLNEMELATIFLGYHIQSSKILRDSMGNSRGVGFARFDSRDICDEIIRKFNGVGIGEEGLPMNIRYADTPAQKELKRVTAERRQFRTNEYNIGAYGTPLVGLSPALYNQQAHWRRNLPQSRRAALREARCLVHSLRMVIPKAFLRSSNSCSRAATSADATISTPTTSECDESVTIRADPAVVATVGKENFQPSPTVKKEVSKKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG58</accession>
    <name>A0A2T4CG58_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1324268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG58"/>
    <dbReference type="OrthoDB" id="5371510at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="797" mass="88588" checksum="63E7AF7A3B36084F" modified="2018-07-18" version="1">MRGLMSEDEIQSYRFAEACRLRVVEQELSVGDTLVFVDFPNLSRRRSRQTDCYGVPYSSQKLRVHSQKLLATGSAKFAEMLSPTYQFRIKRRKKLTKDLPEGVKFVLDLTPPSEGDDLVSQMTQLSLTPGIVKWWAANGLHKVTNWLVSGHDDVCTCGRQRIPGWGAPRQDGMEQGQGQGQGQGQGQEQDGKRSVDEESVLKDSKLPGSNIDDTVVTAPTPQDLISKREHGINQPYEIPDFRNIPDYCPIRHCNGIIRLLMMIEGQDIMFDSANRVWTLVAVAKIFDCTSIIRDRVAQWIMYSDNTKFIEVLPEEALQIGFDLELVQVTQCAFRILVNELALKEAATLPHPGGPSPGESRPDLNWVTVFGRRLGNLDDELHNIVQHAARALVERVSVIPAIFRNQRTLDDWMLDEWVKLRRLESLLGQQSDEASTKASKSLSLLLSAIRRSISTAFFRLSVAAATEQKTALVSMDEDRATYVLPEDFRPLEDILPKLNVNQKFLCPFAYKAMSEMWHSDPNQSKWLIMTRQESPVSVKANMILTAEDVQQAVMANPEMASQPSWAEFMDPSEGPLRIKKPIVDLEALNRQIHDAVAPYSNLWLRHDIEPALNITRHLLLTLNNNEMKFLPLWAGGCNDGTGGVFQEELPPAYWGPSGPGPAYHTGITIPSTSSTSGSLIDGFSTFNVRGSTVRGSTVVGSVDVQDGASTVYAPDHVIADDVSIASESFEADGPESYQEARFAVPAEHQAMGHAVDMMVESVDSDADTASDTTDRVMISVLDGGGDEMDEDEDMSFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGK5</accession>
    <name>A0A2T4CGK5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1133379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGK5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGK5"/>
    <dbReference type="OrthoDB" id="5151057at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21527" checksum="6A8A550F1762EAAE" modified="2018-07-18" version="1">MDPAFEPTFATWEEAVAHVKEVGKQNGYDLVIHSKRPSANNIRTVIMRCGKGRSYISWAKEDVQEIKRRKTTSQKTGCPYRLRVRLCEKPGATLGTPTVTFWSAERVDSEFAGKHNHPPLEPGATPGLRRDGLVKKKAEIIFAWKCGIKAPQILKQLQNDPDPDVRIITRSDVYNLIRRHQRDEQELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGQ7</accession>
    <name>A0A2T4CGQ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1325214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4CGQ7"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32071" checksum="A4F1A58D4FC15F6E" modified="2018-07-18" version="1">MAVITSVPRGDVTATLNYYTAPPDGSQPYNLVGDDHPADLPRRNYGDDFHDVVIHDIRGREADFSLDRDAFQLVQHVPASAEKDFVDDESIKKNYYPEVEQLLLEQIPGAEKIYIFDHTIRRSNPDAPRSPVLRVHIDQTAASVEKRVRRYFPDEADELLKNKRYRIVNVWRPLNKGPVEANPLAVASTSTLEDKDVIPISHRYSDGYVGETAAINYNPGQKWYYASGMTGDERLLIECFDSESLKPGSKIGGRVPHTAFKDPRTREDAEGRESIEVRALVFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGT7</accession>
    <name>A0A2T4CGT7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1398131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGT7"/>
    <dbReference type="SMR" id="A0A2T4CGT7"/>
    <dbReference type="STRING" id="983965.A0A2T4CGT7"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="223" mass="25990" checksum="4F97C870C9011369" modified="2018-07-18" version="1">MRIEDCSFCGRPAYPSKGITFVRNDGKSFRFCRSKCNRNYKMKRNPRKLKWTKAYRRNAGKEMTVDSTLQFAARRNEPVRYDRDLAAKTLAAIRRVSEIRARRERVFYKKRMAGKRERELAAARKLVAENEHLLPRLRGSEKKRLAELAAERGGDEVVVEEEAEMLLATRKNAVKAFGGEQRRVKVRVDGGVEEEVVRTVREEVDEEEDDDEDEDDEDVDMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGU3</accession>
    <name>A0A2T4CGU3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1325098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGU3"/>
    <dbReference type="STRING" id="983965.A0A2T4CGU3"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="574" mass="64053" checksum="35A964F06AE383D5" modified="2018-07-18" version="1">MSSASSQSRVDEITIASNDYHVSSSFSAEAGRTKSQSVNFNANTEAKIKNPLVGIPRRTLLADVDDFCRLKNLEDHRDLIRKGALVAQDPTGYEDITGSEALRPDEIEALRNEVLHKWRVPWTLLLTVLTCSIGAAQLLICRLFMGVGMGAKASTVPIFAAENSPAPIRGALVMSWQLWNAFGIFLGTCANLAVRGIGGEAWRYQLGSAFIPAVPLVILVYFCPESPRWYIKKNRYRDAMRSLLRLRNNPVQAGRDIYYIHVQLEVEAEFMGSGSYIRRFAELFTVPRVRRATLAAGVVMLAQQLCGINIMAFYSSTVFLNAGASSLGALLASWGFGLVNFLFAFPAIWTIDTFGRRSLLLFTFPQMAWTLLAGGLCTLIPGQDGLHLGFVALFIYLFAAFYSPGEGPVPFTYSAEVFPLSHREVGMAFAVATCFFWAAVLSITFPLLLDRMGVLGSFELYAAFNVIALVMIFLWLPETKQRTLEELDYIFAVPTRVFMKYQVTKTLPWWWKRWILLRKDAMLEPLYTLDVADHVDTDDGEDKFENDKAKVELKDIVGFVPTSVNARPLSSETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGW7</accession>
    <name>A0A2T4CGW7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1419336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGW7"/>
    <dbReference type="STRING" id="983965.A0A2T4CGW7"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="676" mass="74762" checksum="359FA6FCBDB259E9" modified="2018-07-18" version="1">MSDPPGNPSGPPHPPSHGPPRPQKANPLRPLRKKPNPLVASSRKPPPKPSRPPANGAPSSSAQGAANGAKPTAEEIRNQYGGWSEPPPNYPYNDIPIMTTKKALLDGIRYHLMKFSQTKLGEKPIDPTDQEEFARPVTLHRRDARQPPPGRTVKVEEPERPPVDEQEAERLAQAKAEREAQRAIDQAKIAPVAKEVVAKRPKKQKEEKTMFNRAPKTSAAKKESDLRYEEALPWHLEDADGKNVWVGSYVAALSESSVAFMIDGSVFRMIPLEKCYKFNSKPPFQPFTIDQAEAFMNRKVDVGRWVMKDEEKKAGLHDLEATRRLLYGRGQMIKTESDTFRAASREEKIEHDELDVSGDEFQDDDETPHFEPQEDEDTKESKTRIRREQLGANLFGEADEQEVDKELQEQLREELERQKYGKTTKKALIKRDREEIYESDDSETNPWSSSSEDDSSDEEEEGAKEEEKKEGDSKDAQSDKDKAKLQSAKGSTTPQGKQKLSDMAKKGKSLKRPGSPTLSESSGNESTRKKQKKVTAAALGSRPGTPGLSQTTVRRPKITAGSGSDGEATAGEMSDGAMQKKKIKLVGSSRGTPSASRAGSPNPAATGASSPSSGGLIEPWEILEKIPADGITIGDLINLFQGRVGDGSGRMPRQEWIGLVKQLCDYGPDKRLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGZ0</accession>
    <name>A0A2T4CGZ0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1324472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGZ0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGZ0"/>
    <dbReference type="OrthoDB" id="5297549at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="3">
        <location>
            <begin position="138"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="591" mass="65568" checksum="BB613F075BDB72F9" modified="2018-07-18" version="1">MGIPHLITTLESYASHEILQRQDVVIDGPALAYHVLHLCRMQGASQPSYGLLTQLVIEWLDRLEDQRVTIRAIYFDGYLPTEKYPVRMERVRKTTSRLSLLYSSFPLGCPRRHVVPSGELSDNPARLGLSADKVAQDPSFVVPAIIDAIRSNPRYREKCFMVPGEADAYCASDVVKHGGTILTGDSDLLVHELGSGKVVFFRDIHENASSKLACTVYAPRAIYTKLGLPKSVEACRLGYERLQSPHATLPMLLKACSRPLSDAVGYDLFRQQYVSHEEASVPRLSGGGLLQLSALDPRVSELLLQIGDAPITVKAKMFLPSLLENPNKGTSWDASANIRRLAYTVASRYLARHGASSVEEYRRVQNVDQKGRDIPLLSSAQANEATLELLDLVKRVKETRIPRHHHWTLLCIALEIIECNQQGKNSHALITLQQQKGRQPMTAGDKIPWDTIHFSAHIQAGIYSLRILSQVLASTMSQNTSTDELALNLMQIRKLLSELPPLTEYPDVCVLSDFLAASKELQILPTLSQFVELDEVSYEGSEQSHTKPQGKKSRGSKRRGESKGDSEKSCKKPNNAGVNRGNMFGALSIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH21</accession>
    <name>A0A2T4CH21_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-protein ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1436322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH21"/>
    <dbReference type="STRING" id="983965.A0A2T4CH21"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="84227" checksum="DD40B38FEF1AAFCB" modified="2018-07-18" version="1">MQDGLGVVPPLAATQQAAGFDQYDVVASATEPDAEILRPLATDSSLYSNIMNVASAPSSQVGGTSAQAPFLSLDGVRGLGSVFGYATSKWALSCLAMAVILNRTHIFAATRRRLRLRWQVRLVLRIVPIVLLVLQARTVLQSIQCQTSPDFALLRWGDANKSSDLMFSHSNPFLNTVSSTLLFGATDEQSCVAAQMVPSPDPDAPRELRGSLSRLWPQFGTYCLSQFLETISCAVQGRSVAAETGMTLFEQSLAFAEADAAVNSQLGWGAFSKYQSPIPASLSQGGTVVMTRAAILRRVNTSPEVLWIAFLSSMTHITSHLLGVFDLQAKYRLANTAFWGLCYMGSLVWSFITFEAENPATQGFFRFPTVCIIGFIPHVLILIGIIMCLFVYGLALLLTAVMPPASQENSGMTFRQRLFRAHENMQANVSLSELRITREMDFYTALLRTGFAAITMASEAVYLNEDRGVSMKRQTWLEEARYREAEELRRQWISMGLSDPRYDQIGTVGLIPVKDGPLLPHNGYSRERAAQKVARGRGDKVIRAGIGASERSSRWLLAVEFLIAINKLLGRVFALSVLWILGMLRLQARPAWLLWLASHTKANGNDEASGRKSRSGGSRDATTKPADGDASLKMDALDIEAEFRRVDSSQDEETIDGDLYKYWLKGGWWGSNDMSGTYQPSQDDEDWDNTSVITMTTNGGDTEDEAGSGYSSEEGSGQRTPTQRSPRPERESTPFLDSPLAMSDLARLLHPTNRASDGWSSCSELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH37</accession>
    <name>A0A2T4CH37_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RIC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1396021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH37"/>
    <dbReference type="STRING" id="983965.A0A2T4CH37"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="783"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB80877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112402" checksum="EFC70DD64D78BB18" modified="2018-07-18" version="1">MYWPIGTPRGQAADDGRVPLKDPVLALRIARTGQMFAVITATSITLWQTKPAVVLALVVRSDSSLESYGTNVDLLLRPDSAILVVHTSKGFLITYSIASDGESRVYKPHFSNYHNVQRRKQSLIGPQSHLRPDQILWGPGEGGGVRDVSVRFRMVIKVDAGIESALALDDELVVATRKPAAVQCIRWTPDSSGNQTRTEILSRMGWVEKKASIVEMTHDRPMNLATWITSDGRAYAVQRQQRNNGTEEESDSAESKRLFKGHCFHIPQDSRGKAVRAVINARFSLIAVGCSDGAIHVYSVRDYEGNIVHSHAHRMPYSTGTTGSFTTLTYSPDGYCLFAGFDKGWATWSMFGKLGSNSFGAEPSISALNGEQWLLGIRGAVWSGGGSEILLIGHKHEAIWSLEMAKNAITGCYNEANVFRTVLQTPTSVMIYRGYDLPDLTSISAEPFLWHTSRIPSSYLLNQWPIRQTVISPDGRYVAVAGRRGLAHYSVNSGRWKTFTDEVMENSFSVRGGMCWYQHILVAAVEDSRTFELRLYSREAALDNSHVLHTERLPAPVVLVTASGEDSLLVYTYENLLYHYIFVPTAGSVRLIQVGQIAFHGIVRSPARVRGLSWILPDGQLSDGDPSQDVAVASVLFLVDGKLVLLSPSLNDEGQLKYDMRIIAQNVEYHVSMRDQTPLNVGHSPEETQVRYGPPALRDSLWLFDGMEIKAWTDIHDLLTAAHGDGGTRELPTPVSVDVDFYPLSILLEKGIVLGVESDLVQRRDVSFSFFHFAIRTHLVLPDVLRFYLVNNMTVEAANLSQQYEGLEYFAHGLEVLLHRVLDEEADTSPKPEDAVLPRVLSLLSSSKEYLDIVLQCTRKTEVRQWKTLFAYLPPAQELFEESLQRGSLKTAGGYLIILHTLDELDASLEQSVRVLSRAIREGDWELCKELARFLAAMDETGEILKEAMKMANVGLTQVSSQDNISSRLELPVTGLGFMTNGRKNKDGSDDGTGSDIRSASDASSMGSTVSPMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHR8</accession>
    <name>A0A2T4CHR8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHR8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015686027" description="Secreted protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9145" checksum="8D623BDD5655C3BC" modified="2018-07-18" version="1">MVYAASGFSTMDAPALLCSILLGTFMAVRSCHGSSSRVAKVVTSAEHNDRDASSRRALMMSTSTSKPAAVIHAAISTVFLAVDNIPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIJ1</accession>
    <name>A0A2T4CIJ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1367352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIJ1"/>
    <dbReference type="STRING" id="983965.A0A2T4CIJ1"/>
    <dbReference type="OrthoDB" id="3029913at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1100" mass="123969" checksum="729A849652762D16" modified="2018-07-18" version="1">MAGRRRRETRARYIVFRHAVRVQRLLANLEDDRRLKPGHQQLHSFVVPGLQGGKHTVDVTQDITAKSASKQLTATQEFYVDTPEFAIPEGEIHSVYPPPGHEERSEALPHVVFNTPEFPWEWRASYIEDVPDYKKNRNRVPWLAVLVFTKDELQLSPDDLQGDKSIFRNTEKLGVGAKQTSTLAVNMLVSDVSKLADTASPVKPSPAEPNSTTDIIFVKNELFSTLFAKYDDKGHEDTTATQADVRPYRFLAHKRDINTEGMAIAALTATEEDQSSYGVVFSHRTGPVTITQPTQIIAHLVSIRGVEIMPWPVAKENRYVAMSSLHSWSYTCLPPDTPRIKDLFEALGRSSAMLRSNVVLDQLNPPTDAPKAVQDRVLQRLHDGYALARYRIQTGEQTGCFIRGPFIPVKIPSEITRPWHSLSTSGSDLQILDQQLGLMDITYSAAWQIGRTLAISDADLVSRIGQVRKQIYDRGMHYYQLAALKAHGTRSKSELIAQLPSLVAALHNLHKTAQLSTSDVQARSRRWLRHSVDPVDLSYSGRETQAVRVTANDEDTLPQFLLKAAKEIASAIDPEKPDQPSDVPYNEFNTPYSPDWMALLKFVLDKQVLENIPFHYLIPDISALPLESMRFFRIDWRWMDALLDGALSLSNYIDQDHDKVRDAIFGALKWYHETGVAEHGGEVPPVPVYGCLIRSNLIVKFPDMKVEVLPAQLPDKPPVLMRHKIVTPDTMLCLFSKEPSEPDFTGLALTQPPHQQTFVGGSDLKKNKIEMRYKKAYTADEGSDDVTVPIAIKEWSPSDPKSKESVYLWDVTPASSPTIEARRLLMESLASDYLKTVQEKMDKKYFDDDTATSALMAAQMGSVAWRLKLKLSQTNAQEELEIDPDVSPSDAPLPEWAHRRRRHPLPSHAIQKLPQFYATRPVFYYQVSSTETPSSNTIVATDIEQDLIFRINLEPYTAGDYKLQELKIKVPFGTPQQFPRVLMATYKGSGAEMTSNIRFNVIIDLETTDEKLTGMILRMVPRSRRGFVPVTSCSEISFILSGVVVSQVTQKTWVDLEIKEHYANQGEWNPKNKPDSIVLVPPLAAERAMNLKRIFSAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIX3</accession>
    <name>A0A2T4CIX3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_85685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIX3"/>
    <dbReference type="STRING" id="983965.A0A2T4CIX3"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015761609" evidence="6">
        <location>
            <begin position="17"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="461" mass="50441" checksum="FEFBDF8AF34C5B54" modified="2018-07-18" version="1">MRVIIVGAGIAGLSLAIALGQSGHQITILDAAAQLAELGAGVQMTPQAIRYLFKWGLKDDLLSESIIPEDLYVRDGHSGDLLGTVRIKDMEAQYGAPYIVVHRAVLHAILHRHAIRAGAQLLLESDVVEYEFANGAVQLRNGNRLAADLVVAADGINSLARSKLLGSSDPGSQPTGWAAFRVTAEVSKLRADPAVASLIDLQSRSSNWWIAPQLSCMTYLIKDATLLNIVLSHRDDINTKDFTAIEYNKTVRNRFKDFESRVQRILNLSRPQIVNYPVYAVPPLPSWTHESGRFVLLGDAAHAMAFYMSMGVSIAVEDAAALVAALDLACPPDTGPNFAHGRAEEVASRLKHALRVFETVRKPRVEAVQEASLHGGDSSHTSDEMERSILYEALGHSHETEVWPLESDARRGEFVRKSRRTGQRLGPGGIIDKGTRDWCYDYDAVRAIEEAYKSSSTAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ00</accession>
    <name>A0A2T4CJ00_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1459685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ00"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ00"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="561" mass="59892" checksum="BB107FAB27FC0693" modified="2018-07-18" version="1">MKIPYNRVHVQGQILFAARGGAIHTFSLTDGSHISSWKHPDVDRVAQSIQAINEAKAEAAAAAATEAEADTPVTESEGPPAKRQKLEGDSENPSVSAQVEASTPTTAQGGEKPQAGHVDGRGKKGKGKGKGSVDSGKSRFARVPDRPVVTHLTSTPDGKHLVAITGHDKAIWVFEHDGNGQLKQLSKRTMPKRPSAVAIGPDNQIISGDKFGDVYAIPLIIPEDGSKSAASLSSLPLPSKKAFKPTATPLTVHSKGNRLALLNQIKQAELAAQANEANSTGPDFEINLLLGHVSMLTALVLGEEQGRRYILTADRDEHIRVSRYIPHAHIIENFCFGHKEFVSEMAIPPSKPDVLISGGGDEDIFVWDWVAGKQLYKSSILSLAREIAPETATVAVSGLYNLLYPSADGPLTYILAICEDIKAIFSWKLNDSNELHCPGIIQLPGKPLSLAISPSTDGDSTIPPTVIAAIDPDADTQAQSLHAFRLTMDNGRLAVDVETSFKDKEVEESEPELTEEDVRGLLYTVESLRKVVTGPDDEAGSEAPHGNAESDVAGNTGEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ34</accession>
    <name>A0A2T4CJ34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 calcium/lipid-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_63417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CJ34"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="689"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="894"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1381" mass="157150" checksum="C0D1D53DF99F4CAE" modified="2018-07-18" version="1">MRWQVLFKTFVRPPSTRDTGRPRPQSTAQHPVDPDEARSFALRTAYLHYLLQPKAKRKQYVPAPKVPTRAHTSVGQLVQDFVSGTSTSIKLPHNFAAALLDRVGGVLRGSEALPGYSDAAVKRSFAEAYTAFSEKAFRKTIEKERKFEPLVLIFYSAATKAAQKGKTPDDESDSWKLLPDRHLAMFVRLAASVMRDLGHDRDRPELMARLKDLETKLLRNDQDLVSNGTAGAGTTIEVIVPLSYEVKDMPMVQIVASIYGMGLSEVQAEINANRQVWTEEAALKDLKSYQTRLNANMPGTLSSHDFDVEDAFQEWKKHEATHLSQMMMDILTAKPELAKTKTGPLDKSLPSRPTSLYGDDQAYADLSRVISDPDSSSFAFDSSISLSSLAIGESSSIRTVDEAIYTFTPPNPRAYYKHILQQAMLFDQIHADPNMDYQPLSHKSMELLTELCVRWRIPQFTRLIVLLEAATNQFLEKEIAPEDLDAVFDMIKSPSQELKKPPHIHAYNAPLTDFDPSRWTMHDFAAYQHTLHTLHDALLQELFDLLEGCYDVKPPNIGPVMYLLENHIGQDPTFSPRAEVMDEFRQLLSERLAQKATAVYHEIMQKQIPERKEEWEFAHVVQLGKAVTKVCDRIRKRYKKTSTIMGVDPLSILVYEVFPKFEQDASAIVQIIMQSASETGQDIEIQDGFELYKELKEIRDIHEEFLPKEPFAFNIEDLLVDFVWRWLASAEARMTDFVDQAIKQDKFQVRTESPDQIPGDAQRHSVSVIDMFMLFNQTVDQVFKLEWGNPEHHARFMTALARSFSTGIGRYCETVDQQFAKEMDRPSAQELAAQTQSTQEKWMQYAKDAWNNKDKAEPFQFFPESFVKLNNIEYAMQELDKLEKTMNVEACAALLEKKDGVKKKTRKPNKYTFTIKVVEAEDIKACDPSGYSDPYVVFGDEYQKRLHKTRIVHRSLNPRWDESFDITVQGPVNVIATIWDYDTFGDHDYVGRTSLKLDPNHFGDYLPREFWLDLDSQGRLLIRVSMEGERDDIVFHFGKAFRHLKRTERDMVRKITDKLTVQINETLSLETLRNLLGTGGVGASITSLWKKRTSTATPSAGPTQAQIESALTNLFAYFDDNFAIMKMTLTDATMIAVMTRLWKDVLMTIENLLVPPLSEKPSTQKPLTRRELDIVYHWLEMLFNFFNAKDEHSGEQLGVPAEVLKSPKWHELASLNFFYFEDTNNLIRESERMAVASAQRAQQALQQQNQPQSQQSSGSRLAVPSSLGASLGGAGSFASMGTIRRGKSIMMSRNLGTMRKAKEAKRREAQADASDDMILRILRMRPEAANYLKERQRQKERQAATAAAALIVRNSVNQGWNSGPPFQGAPFGRNSLLPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ69</accession>
    <name>A0A2T4CJ69_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1467044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ69"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ69"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="318" mass="36119" checksum="DF20FFED49B5680E" modified="2018-07-18" version="1">MARPMGSSPRSGAVQGPPPVTRYNLNKVTVTSDPVRNQEHILILTPMARFYQQYWDNLLRLNYPHELITLGFILPKNKEGNQATSMLQKQIQKTQNYGPEKDRFKSIIILRQDFDPAVVSQDESERHKLANQKARREVMAKARNSLLFTTLGPSTSWVLWLDADIVETAPTLIQDLASHDKPIIVANCFQKYYDPESKKMAERPYDFNSWQDSETALKMAEQMGPDDILLEGYAELATYRTLLAYMSTPGGSQDLVVPLDGVGGTALLVKADVHRDGAMFPPFAFYHLIESEGFAKMAKRLGWQPYGLPNYKVYHYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJC3</accession>
    <name>A0A2T4CJC3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1396772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJC3"/>
    <dbReference type="STRING" id="983965.A0A2T4CJC3"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="575" mass="62033" checksum="69D4ECB079B5CEFE" modified="2018-07-18" version="1">MAVQDDDIIAPALDPQAEESCKEKTRKRTLGNLRLVHPETNAVILVPTPSSDPNDPLNWSTWRKYYVAGVLCLAMAVCNFLAAGPAIAVPATAADFFPDSLLDGTFTTSAIPKTAYFFTTTSLLIGLGNIIWVPAANKWGRRPVYILSYAIYFATAVWLIYEKSYARFLAGRVLMGFGSGAAETLAPITIADVFFLHERGRVMSAYTCFLSVGASGGLVISGLITVNHTWRTIYQVGAALVGFVLLALLLTVPETSYSRTNDDASLALEVADDAATTSTTQEGQSSVKKMSYVESLFVFKAAGTSENLFKMMVRPFGLIILPPVLWSALALSVTIGFLVAVSSNSASAFNVTYGFASWQVGLCYISGVIGALLGLPAGGYLGDKVADILTKRNDGIREPEMRLPAVMVSVITMPLSLVLYGVGIQYQLHWICPTLGLGLRKNQAPTSHSASRILSAHRHQLTHETQSTSPSRRPTQSASCTSLIHTGPLRARSRWQSPASKPSSPFSYPLKRTLGSMPPAIRTVSEPWRELRGPFSSCGSRCISGESKSGITRGNGESFPLSTGTMIARWESNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJL9</accession>
    <name>A0A2T4CJL9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1396923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJL9"/>
    <dbReference type="STRING" id="983965.A0A2T4CJL9"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="325" mass="35022" checksum="624AA81FEB0F1DF8" modified="2018-07-18" version="1">MATSSYTQDRTPTARHELKLAIHKNEGIEDKSIKLDSIIDAEDAAKERRRKQNRIAQRKHRRRKAEQKLSAMSKSPEIRVSPLHPGPCCCCVTRRPEMVAPPDDYNRSFISIASPNPSSSYDPLTPSVVSDYDSRQTLSASHWTPFWPAASPLFDAEAGSALPSGDPLENHSHSPIPSTASLDIPPFQDSHSPASALSYDASISLIARPSNTSLSPESHLGGQFPLHLAARGGYIGIMSLLLSRGARIDAKDTCGRTALHYAADAGHLDAAGMLLSVGANPFLVDSDGCNSLHIAASKGREDIVRVLMERGMDPNLGVGSDIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPM9</accession>
    <name>A0A2T4BPM9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1344638</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679151">
        <property type="protein sequence ID" value="PTB71209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPM9"/>
    <dbReference type="STRING" id="983965.A0A2T4BPM9"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="279"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="539"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="539"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB71209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="72031" checksum="65D78A2D54F83EDC" modified="2018-07-18" version="1">MSSQFADGVVPNPQFALLNYFFPGFSMLTTALQTYLGIDLNFYIPLLVALFGLNFAWGYISNTAWSWIDAYLMSSFRVRTDDETYNMLMLWISRQAFSQNSRRFLVNTDLYSRNSYIWGAGQDDSDDEDGEEDAAVDILGPKQTLHYTPSFGSHLFWYKGWPMLFERIQNNQQLNFQSASEREELSVSCFGRNPSLLKDLIIEARQLYLKKDERKTLIYRSASGSYGGEPYWQRSMSRPNRPFSTVILSEKMKQDLIDDAADYLNPATRRWYANRGIPYRRGYLLYGPPGTGKSSLSLALAGYFRMKIYIVSLSSINATEEGLTSLFSNLPTRCLVLLEDIDTAGLTHTREEPDPAAAPAPPPNPSSPNQAPGQTPAGGRLSLSGLLNILDGVASQEGRLLIMTTNHIEKLDKALIRPGRVDMMVPFSLADRTMTQAIFRAIYAPFESEITSDEVATKPKIKKGVVVSKRAEPDEAAKERWAKQHAEISQRIEALSLEFAAKIPEFEFSPAEIQGLLLRHKRSPEDVIAAADAWVIQTRKDKKDKEVQEAEKRRKEQEEEEKKRKAEEEEKKKDEEKENGKAKTEGSDEKENAQAETANDTVKDSPSVGEGDAGKADEAKAEASKDDKKNTASDSEYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ19</accession>
    <name>A0A2T4BQ19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_350809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ19"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16553" checksum="1F8421F45FC3CD3C" modified="2018-07-18" version="1">MATRDANRSRVFQRGPSGQSRQVAVPADDEMTRVSVTGPCHLTSVDTVPPNHQRLPPLVPIGHEGFDTPRKHTISTKRLPNASGCPSFAQISRHVHPVNPPVDAASRPWIAIRPRRRLPSMEKQQQQQQQQQQQQNKKRSDKLVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ77</accession>
    <name>A0A2T4BQ77_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1344078</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ77"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ77"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="13">
        <location>
            <begin position="284"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="13">
        <location>
            <begin position="382"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="466" mass="50715" checksum="7FF78FBF71DDE2B0" modified="2018-07-18" version="1">MALTEYSANPSPPPETIEDGAALVPEDLQLPDGHPDYLRMIASATSRVYEACKITPLEKAVNLSNRCECNVMLKREDLQPEECARRAKHDGLINIPPFDDPYVIAGQGTIGSEMFSQVNMAKVEAIFCGVGGGGLIAGIGLYIKRMAPHVKIIGVEASDANAMAQSLKLGKKVTLPEVGLFADGAAVKVPGEETFRICREVVDEVVEVTTDEICAAIKDMYDDTRSGLEPAGALSIAGLKKYVAGKPSVDSKRTLIAVTSGANMNFDRLRFVAERATLGEGKEVLMAASIPERPGAFAKLVDTIMPRPVTEFSYRYSSGDVANVLIGLSITVPAAERAEEVRSLMERIRGEGMEVTDLSNDELAKSHVRYLIGGRTGVENERVFMFNFPERPGALEKFLSTLRPKFNISLFQYRTYGGDVAKVLAGIQCPPEENAELEQFLEELGYPSEECTDSAVFNMFLKSTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQN9</accession>
    <name>A0A2T4BQN9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1395556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQN9"/>
    <dbReference type="STRING" id="983965.A0A2T4BQN9"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="505" mass="55182" checksum="3A3DE3DB297D4724" modified="2018-07-18" version="1">MATVQTPAAAPAAPAASAPSTAPPQTSSNGANGNRPKRPNPNPNSSSNRNWKQKKTKREKNITEGSSEEVLRHDIEALLASRKSETSGEEATTTTTDAQEEATEEETLPAEGTETEVEVLELSSTGDGLAMRPGSDQVYVVPFTVPGDVARVKVFRHLRREKQTVADFVSVVKPSPLRDDARIQCKYFASCGGCQFQMLDYAEQLRRKRAIVDKAFRNFANLPAELVPAVLDTVGSPLQYGYRTKLTPHFDGPPGFRPHRQELQGVENLPPYTVRAESEFGIDIKTCETDSKATTHEYIRDHHFTNPAGSFFQNNNSILPIFTDYIKQHVLPPASPSSSSSSSSSSPSSEIKYLIDAYSGSGLFTITLASVFQHSTGIDIAADSIASARQNAALNGLGEDRCKFIAADAGQLFKSVEYNPDQTTVILDPPRKGCDADFLGQLRRFGPRRVVYVSCNVHTQARDVGVLVRGEGDGRRYEIESLRGFDFFPQTGHVEGVAVLNRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQU7</accession>
    <name>A0A2T4BQU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1139613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQU7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="180" mass="19370" checksum="743D2347CD38ECFC" modified="2018-07-18" version="1">MPSPVPSTDTAFFLILPQTLASRPTSDTVSCWHLTGSSSSNFSRPTSSTELGGDPSSIFCRGLRILSIDHFGAFGFWSPGRPSCHGDEPDFGHVDQNLAHTRTDKHLSCARLQHSRASTPNALGVPPANFIAIQNCLDLSTDSAASPTGTLFLSGRCLQFSTHHILFYCRNTCSTNTLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQV2</accession>
    <name>A0A2T4BQV2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1406207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQV2"/>
    <dbReference type="STRING" id="983965.A0A2T4BQV2"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="641" mass="69252" checksum="55E238504B875A59" modified="2018-07-18" version="1">MRQQHPRPQVVMPSCGVSCIDNGVKFLPIVSFDVHTSIVASSSRTVLKQTFATAGRSLKHVRYTFPLYDGSSVVGFQCTIGSRTIKGVVKERSEAKQAYDTALAQGQTAGLFEQSPEAADVFITSLGNIPSDCQSVDVHVTYLGELKHDAQVDGLRFTIPSRLAQRYGQHSITESDAITFQGGKHMKITVDVDVSSGSVIKSIQSPSHPISVNIGTLSTATSDPPSLQRAHATQAQGSFVLGNDFVLQIVATGLEDPMAVLETHPTIPSQRALMTTLVPRSNLPMEMADVVFMCERSSSMAGANKMGNVTEALNLDAANARQENAKRDEGAEDKDISFDKFAQAQASARGCFPSASGSARKRKSSTLVEADEDQPVREAAMSFRDATPQAMAIHTPQGMPVVETQILQNTQLNGTIMTHHGRRMPLSESAQQQIAAAYQMLQLRQQAFSEAARFDDGQTAALRAAQAAQRAAAAQQAASAQLYWQYQQWLQNQQGRMGRMGMRASASSYGNYPMGAGPAPAPLVYSNPNAFRDSANASPALMLATLQTFAGSWNWGSRLEAVLGVTAQLAADGIQLPGDCGTEQTEVLATLCAVVFLKKKLASEKESWELLVQKAELWLQQQMGADVAEWEKMVEDKLFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQV7</accession>
    <name>A0A2T4BQV7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1364999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQV7"/>
    <dbReference type="STRING" id="983965.A0A2T4BQV7"/>
    <dbReference type="OrthoDB" id="5431381at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB71703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="721" mass="81105" checksum="D4E44F2F1D3D3257" modified="2018-07-18" version="1">MEFGPRRIEKRNRAPVSCEPCRARKQMCNRGQPCEGCTRRNQASLCRYAPNAIRNKPRPPKPGNIQERLDNLEMMLSSIASNPSVAALGMGVKTGKHAASNSTNRVSAAVPQYRASATPPQTRQEDHVLPPEQPHRHESGNGQVSYIEPSHWRAILDEIKEVREHLSAFDRPWLQEEPERKSFVPEEGAEYLFGRFPVVELEDVISSLPARSVCDALVSQYFNSRYMVLGILHPAKFQKEYEKFWEAPVKAPPLWVALLFSVLSLTTALRHMAVPSETTSSSSGPAVSTLQQRTVECLVLGRFATANAYALEAMMLHLQSCYLTHNKLTSDHWFEMGTLIRLAFRIGYHRDPDTLPGISVFDGEMRRRVWHNIFQVDALMSFQMGFPSMIPTEFCDTKVPRNLQFSDLEIGMTSLPPGRPLFENTPIRYPIAKSGIMAVFKKIVAHSQSLSLPTYENTIMLDGEMRETYNTLPEILKSRDVSRSFMDPSSLIFERCTLEMLYLKGLIVLHRRYISYDVDSRRFEHSRRTCAEAALDILARHADLHQAAQPGGRLYDDRWMVSSLTMHDFLLAAMVVCLDLSVRLRRPSSILSPGKDHDALTRREYLALQKSQAIWAADSAISPEAGLAASALRLMIQKVAEKDASLASQSVSQSHLAAENSSIAVSTGDLPYAGPMSQMIDSIEGLNWGLLDQYFQNQPVDGTHMEGFHLDAGTSHWFDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRG9</accession>
    <name>A0A2T4BRG9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1768-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_22976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRG9"/>
    <dbReference type="STRING" id="983965.A0A2T4BRG9"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="197" mass="22247" checksum="A9876E177388EA00" modified="2018-07-18" version="1">MDESTDQSGPVYFFRETDPETGYLCQWYSCPFRDDKDPNIIYQTAEHYMMYQKAMLFNDQASAHKILPKGQTPRKVKSLGRKVDNFSEETWNAKREEVVRQGNYLKFTKAVKEVGYCRGSSSGSEPLVGGSLRETLLSTGERELVEASPFDAVWGIGFRAADADGNREAWGLNLLGKALMDVRQRLRDEKAAAARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRH6</accession>
    <name>A0A2T4BRH6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1343248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRH6"/>
    <dbReference type="STRING" id="983965.A0A2T4BRH6"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="58"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB71894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="556" mass="60284" checksum="698C8548431E1FF6" modified="2018-07-18" version="1">MSPHNKSGKLDDEPRLDDVSADDAPAYHPQYGARSLDAGDNDLIDPDSGVKRGLKNRHLSMMALAGIIGPGLLVGSGGALNSGGPASLIIGFGVIGIIAFSVMQSLGEITTLYPGGGAFVSLAERMVDKSFSVAVGWNYFIIWATVLASEYNVICSILNFWAPTVPLWGWFLILWTVFLAFQIIGGITAFGEAEYILALIKILGLTAYFIFSIVYASGGLVGQDGAVGFRYWHDPGAFNGNGFRGVATVFVFCSTFYAGVESVAVAATETRNPGVAVPRAIRQVFFRIIFVYMGSAFFFGLTCPADSDELINGGAKALQSPMTIAIQNAGWNGGVHLINAFILITCLSAVNSSIYIGSRTVLYMAQSGKAPKVLGWVNKHGVPVWAIVLTNAVGAISMMNVSTGASKAYSYIINLAGVSTFLVWGSISFIHIRFRRAWATQQRRVSDLPFKSMLYPYSPYFGVFANVFLALVQGWTTLAPFDAGKFVDAYILLPLFGVIYVLCKLYWRGEDRFKRSWDIDLDSGRRSDLDKSDFVGDASVERTQKVSPWKKILSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRI4</accession>
    <name>A0A2T4BRI4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zf-PARP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1343001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRI4"/>
    <dbReference type="STRING" id="983965.A0A2T4BRI4"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="406" mass="44527" checksum="48E887FD9E7A9275" modified="2018-07-18" version="1" fragment="single">HLSATAHIPSSTSDLTAHLRADLIPLQTWVNIALISPNRRAGCTDTVCKQGEVKIQKGELRFGSWTIIKEHGSWRWKHWGCVSGSQLVNLQEACGGDPDNYDFDAIDGFDELQDEELKEKVKRCVIQGHIDPEDFNGVGLVALQSDPEKNKPGEKGIHLTAKQKEAKAKAAAKEAGESQAGESQKTTKRGRKKAADDVADEPKPKKARKSNKDIEADEEQPKAMAKARVKEEDDVKRPASAKRGRPGRLSVQQDEEVESEEADKPAAAKKVAKKGSKAKATKVELEEEIVKEEDVDEEEDNVKEEEEKVVPVRAQSGRKRLSSRAKAPTTDEDESAAKDTPVSASRGRKRAAAVPQVEEQDEETPKPAARRGRKAASAQKAEADTVEVAEEEAPKPRGRGRPRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRV4</accession>
    <name>A0A2T4BRV4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1405792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRV4"/>
    <dbReference type="STRING" id="983965.A0A2T4BRV4"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015697740" description="Translation initiation factor eIF2B subunit gamma" evidence="11">
        <location>
            <begin position="24"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="432"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB72034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="561" mass="60516" checksum="1DCB372CD0199E9A" modified="2018-07-18" version="1">MPHALSMASTGLQALILCGPGSSFPTFTSNPDENPKALLPIANRPMVWYPIDFCLRTGITSITLICPSSASKALTAALNTNPYLTALPLPRPDVLAPADLDQNTGTAEILRLPEVRELVTGDFIVLPCDLVCELAGEQLLQAWMVKSASLTGLLGARQLSNGHQTKYSGGLGVWYNTKASAPVKGEETDFIATAPLPTSSTAPPKGSIFQNLSKLVYSMPTDSFNDLTEERKAIPIRHGLVKANPRVRMYTTHRDAHIYIFPRWVLDFIKKNERMESIGEDVVGWWAKAGWQAGLADKLSFGEVCRNGDEDEDGSELEGRSSPAESAPGNQESPTDAVSSINIAKDGQYTGDKHGSAATASKFEPPSILAYIHSQKDQAAPGSILRRVDTAQLLLAVSLQLAKLPSIEEDPENPSPFAHPKKVAYPEGVKPRTTITKQDSLIAENVTVEEKTSIKETVIGAGCQINEGAKLSQCLLMEGVVVGKGCKLTRCILGKRCIVGAGSVLTDCEVQENLIVEPRTEDKDNKLMSSEGLEATEAEMEEVLQEMEEEVAATGEDVDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSN6</accession>
    <name>A0A2T4BSN6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1096379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSN6"/>
    <dbReference type="OrthoDB" id="4629699at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="116" mass="12871" checksum="9AEB199CC3EA2861" modified="2018-07-18" version="1">MCHGHPRYHSCAHTSLVWYYCPSAHIDLETGFETPCRNVSFAPAQSSALSCPLKNCHFVDKGGSWICCKCNQGPNMQGWCSAPIANAPDDLDSLRLDDEQRTCDHGCCDDCRRFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT65</accession>
    <name>A0A2T4BT65_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1425630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT65"/>
    <dbReference type="STRING" id="983965.A0A2T4BT65"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13952">
        <property type="entry name" value="7tm_classB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="441" mass="49459" checksum="0CD1D60526A59080" modified="2018-07-18" version="1">MGALTAGELETISNIERGCSVVSLIGCVFIIVTFCASSSFHKPINRLVFYASFGNMMTNVGTLMSRSFISQPHSPACQLQGFLIQMFMPADAFWTLAMAFNVYLTFYHKYDARKLRRMEIPYLLCCYGIPFIPAFVYIFLKNKDGFRAYGDATLWCWITTEWDVFRIATFYGPVWVVIFATFFIYIRAGRTIYEKHKQLNDFHSSEGLSSIDVITTLRTTEVTVTTSEAMPPNPADFRPHADPDANYSVHISASAPAGDKIEPVRPVVTEAAKKSRVGRKKDPARRRNYEINNAAWAYAKCSLLFFTALLVTWIPSSANRVYSVVKAQEINAPLETMSAFVLPLQGFWNAAIYAVTSWEACKSFWDDIKTGKRPEVMELVGGADPQDESNKRHSRGITNFRPGNRSKGMDSESMTELNTRTPSADAHSSVETNSAYGRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTH1</accession>
    <name>A0A2T4BTH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1405033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTH1"/>
    <dbReference type="STRING" id="983965.A0A2T4BTH1"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="328" mass="35629" checksum="67405CB3086EC340" modified="2018-07-18" version="1">MADTNMNAIVISKFGGPEVLKIQKVSRPEPVEGEVLVEVLAFGVNHAEMHMRKGEWDEWNPITGLECVGVIAACPGGEIEVGTKVAGVMGGMGRNRPGGYGSFVNVPVANVVPIKTELPWEYLAAIPEVYSTAYSCLFTILDLKSGESLLIRGSTSTIGQAALHLAVDVGARVTATTRREERFSFVKEMGAVDAKLEHKGLLSEFPNGFKFDKILNLIGNSVLLESINLTRAGGRMLQAGWLGGLEPVANFNPMVEMDSGVHFSLFHSKVLGSPEFPMSRIPLQEIVSKIEKGAWDARPAFVFEYRDIQKAHEMLDSHNAGGKIVVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTK8</accession>
    <name>A0A2T4BTK8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1405086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTK8"/>
    <dbReference type="STRING" id="983965.A0A2T4BTK8"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="652" mass="72709" checksum="F7E47A3C8F0CE225" modified="2018-07-18" version="1">MLDQLSLDGRPRGTCFSPADISPLLTQYYMYSLSQRLVYSSSTAGNTSCYHAVQVFVFSVIATMSLSTETCWTCRIRKKRCDRKQPACSACHSLDITCYAGNSRPSWADDALEREKVADRIKAQVKVKSERRREKSYVKVMPLGRARKTEDASRAAQRQPEKSNPDAQAPEKAPLVPICQGCAKNGVPPPIERDGVQLDSSNPGLLGIIQDIDVDLEIAFLDYAFPFLFPFYRPSLYEGGRGWLLATLRKSMPLFHTAMGFSTYLFTLAMTDLANEGHDTCRAIVEGKLTSHIGTAIKAMRKGIEELGTAQNPSSIFERAHLMEGVVQLLVFETNIAGSTDWAIHLDAAVSLFREIFKLRTERDGRTDLESVLDMMQGSAWSTVTLKHRIWNPDQGAFLFHVAFLVFADIISATIRSSLPLLRDYHPLLLHGNPGAEDPRQHLSLEQFVGCQTWILVLISDIAALVEGKKQGRVSRNDLLVEGNRIAEILQDGIAKLRDQLGKPVPITNPLFQAYSNPEAPPQAQDITSYSLIWAHATVLYLFVTTSGWQDKHGIVQENVSSALQLLDEVSSPAVLRSLAWPFCVIGCLASSDQEGTFWKIASRMGPFSAFGTLFEALRIMERVWSTRGERDVENWDFSYCFRILGSMPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTS8</accession>
    <name>A0A2T4BTS8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1441618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTS8"/>
    <dbReference type="STRING" id="983965.A0A2T4BTS8"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="39366" checksum="A98446C814EEA48C" modified="2018-07-18" version="1">MPRTLNVADIAWFFHNYISELAKWYDLGDARRQFETKVPLAALHEPLLFSAVIALSAEHLCQTTGPKIARETASFYHGHCVRRLIQLDEKSELLTNGVALAAACLLRSYEILDEDVDPNRHLRGAYSLASCEGSIAGSPPDSLLAAGFWNYLREDITFSLFEGCPLKMDVTESAAPSLVDGHDQQLHSISLILGQIINKAFRSGISATDWQQLVDMVHVWFEELPKHVQPFSRGRSVTLSTVGELPSFWFLQDFHDQLSMLPAVDAGTGATGHETTKEDLLDAYALEICGIAFTTNIPSMLVNSFGPIAYCGKFIRSEQARQEAIRRLSACKRPVGWPVERLIFSLKHGAESGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTU0</accession>
    <name>A0A2T4BTU0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 69 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_149726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTU0"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="371" mass="41584" checksum="B1E20004C5E78613" modified="2018-07-18" version="1">MLLGAILPAANITRYFEAILTPELSTLPKLKCPAINSTRYGELKSKGLSGPAIQYYFALNLRQNLALLPQLIGSIVEAILFLGPSQCVLSIVEGNSPDGTADVLAALRPALERIGVRYYFESSAIDPSKEDRVARLAQLRNKALAPLLDLHDMATSDTTVIFLNDVAACAEDILELVHQKRTLGADMTCAMDWTYVGEHPTFYDVWIARTINGDSFFEIPPDGSWDSAWNLFWNADESRNRFYSQRPFQVFSCWNGATAFTAQPILERSVNFRAANESAGECRQGEPQLFCKDLWFKGYRKIAVVPSVNLEYSVDKARKIKEAKGFTSDTVSKQDSAGDGIDWRLDPPKMVKCMPTWDNQYWQSWNDTLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTX3</accession>
    <name>A0A2T4BTX3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1383860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTX3"/>
    <dbReference type="STRING" id="983965.A0A2T4BTX3"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015374326" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="299"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="452" mass="49557" checksum="048DB396AAC83908" modified="2018-07-18" version="1">MWSILSVAAALFAAAVSAVSTSGNRLLVVLDDVAEKEAYGQFLGDLTARGYQVSYETPRSEGLTLFHLGERTYDHLLFLPSKVKGLGPNLTPNRLVDFVNANGNILVALSSKVPTSTSLVSLLSELDISLPVERTGTVVDHFNYDTISAAESHDVLVLDAPSNIRPGLKPYFELPGGVLAFPHAVGHVLGSGPLLTPVVRAPATAYSYNPKEQAEVLDADELFAAGQQLALVSVMQARNSARVTVLGSAEMLQDKWLDAKVAKLGGKSTKTENKEFARRVAGWTFQEIGVLRVNSVEHHLQGSEELNPGIYRVKNDVSYTISLSEYVWDKWVPFVLPEDDLLQLEFSMLSPFHRLNLELTGTTDDAAIYGVSFTLPDQHGIFNFLVNYKRSFLSNVEEKNTVSVRHFAHDEWPRSFVISGAWPWISGIGATVTGFLGFCAIWMYSKPVGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTZ8</accession>
    <name>A0A2T4BTZ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1405251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTZ8"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="86"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="201"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="301" mass="33122" checksum="15AC2587399901BC" modified="2018-07-18" version="1">MKEIYLAGAAAAFTVDLLVYPLDTLKTRYQSQDFIKSPLTKPLALRGLYQGIGSVILATLPAAGVFFSTYETTKSLYTRHLRNSLPTPIIHSLASATAEMASCLVLTPGEVIKQNAQMIQQQQQQQSSHTTPSRSTSLLAFKRVLASGRLFTGYSALVARNLPFTALQFPMFEHIRARLWEHRSHTKGMQKTDRERRGVGESGLIAGSSAAIAGSIAAFVTTPSDVIKTRMMVSIDDEALSTTTASRKGLASIRVVRDVWRERGLRGFFRGAAFRSAWTAVGSGLYLGMYDAAKLWIERRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU61</accession>
    <name>A0A2T4BU61_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1433613</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU61"/>
    <dbReference type="STRING" id="983965.A0A2T4BU61"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01068">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="604"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="843"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB72851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="879" mass="97389" checksum="6D956543A75CBCC3" modified="2018-07-18" version="1">MAPKQATLGKFFGARAGAPVRQTTLAFATKAGSKTAAKDKAGEDGSEGDASTKENSDPEKDTRKRPRSPKKSQDAQSSQDETKMDIDEDEAPAPVTKRARRTRVKIEDDEDDTPQSSPKKEEEAPSSPPAKKRSPSPKSSPRSRSSSPKPTQIKKETKSAAVEDSDEVMKDESSSSESASEADSESEEKKKVTAKARKAQQTMLQKHEKDPYPDWKPGTPVPYAALCKTFSLIELTTKRLIIMEHCSRFLRQVMRLTPDDLLPTVLLMINKLAPDYAGIELGIGESLIMKAIGETTGRSLQVIKADQKEIGDLGLVAVKSRSKQPTMFQPKALTVRGVHEGLMNIATVSGNGAQGRKVDGIKKLLSASDAYLKEKVDITKDKGGPSEAKYIIRFLEGKLRLGLADRTVLVSLAQAVVAHEAEQKGTIPSTTDLENGESILKTVYSELPSYDVIIPAMLKYGIFNLREHCKLRPGVPLKPMLAKPTKAITEVLDRFEGQTFTCEYKYDGERAQIHYVAKDAPEDLSAPAAGVAKPAASGVSCIFSRNSEDLSKKYPDILEKLHTWVKEDTKSFVLDCETVAWDVAEKKVLPFQQLMTRKRKDVKAEDIKVKVCVFAFDLLYFNGEAVVEKSLRERRELLHTAFTPVEGEFAFATHMNGQELDEIQSFLDESVKASCEGLMVKMLDGKESGYEPSKRSRNWLKIKKDYLSGVGDSLDLVVLGAYYGKGKRTSVYGAFLLACYNASTDTYETVCNIGTGFSEQVLEDLYAQLSQITIARPKPFYSHSSGGQHQPDVWFEPKYVWEVKTADLTLSPRYKAGWKEGVDPAGEKGISLRFPRFIKIRDDKKPDEATSSRQVAEMYRKQESVTKNKGPSVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUK5</accession>
    <name>A0A2T4BUK5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1465087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUK5"/>
    <dbReference type="STRING" id="983965.A0A2T4BUK5"/>
    <dbReference type="OrthoDB" id="9975943at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="125" mass="13861" checksum="36F35C6BAB36FC3E" modified="2018-07-18" version="1">MHLILTGATELVGSGILDAKIKHSSRCQWRCFWALCISKSKVTKEEYVEYTKDEAVAAARAFSSLSCSEDHAFRFVYEGATQELGQFTAAYARTKGETEVADDCAVKNGMSWTLNNKAIRRVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUK6</accession>
    <name>A0A2T4BUK6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1424996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUK6"/>
    <dbReference type="STRING" id="983965.A0A2T4BUK6"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015367765" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="24"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="713" mass="79001" checksum="88F9EAB6D0A286F9" modified="2018-07-18" version="1">MIGTRKTGRRGLFLLLLASSSTAFYIPGWSVKTYKDGELVPLMVNKVYSDNTQLQYAYNDLPFTCSPTGNHKAGGGLLSGQSVPLNLGEVLRGDRIVTSDMELAMAKDTPCTLLCNKELSRGDMRWTKELIRDGYVAEWIVDNLPGATSFVTADKSRKYYAAGFKLGYTEASPKNGKLHYYLNNHHTIVIRYRKAPGRAGDRGEKVIVGFEVYPKSVGNGNKKDSAGCPVDIQNVDDPFELYIAPNRTADASLKYDGLSYHPDEVEDDDGSPGSLIIPYTYSVYFREDESIEWGHRWDLYFVNQEEGTRIHWMAIINSLIICGLLTGIVMIILARTIHSDINKGISAEEGKAKGKKVAKPKGEQTAGLLSQGPDDKNDEDDLSDDGEALEEATGWKLLHGDVFRKPRLGILLAPLVGSGMQLFFMAIGLVSLGALGVLNPSFRGGFISVGVGLFIFAGLFSGYFSARVFKSFDGADHRANALVTALLFPGLTFGLVFILNLFVWAQASSTAIPFGTLVAILVLWLCVQVPLVYAGSHYGFHKAGAWEHPTKTTAIPRQVPRQAWYSKSIQAVLLAGLIPFAVIFIELLFVFQSIWQDKSSYYYVFGFLAVVLAILMVTIAEVTIVTIYAQLCAENYHWWWQSFFVGGGSAFWVFLYSLWYYFFKLHISGFVSSMLFFAYSFMACCVYGLLTGTIGFLSAYAFVRRIYSAIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUV3</accession>
    <name>A0A2T4BUV3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1340237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUV3"/>
    <dbReference type="STRING" id="983965.A0A2T4BUV3"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="27027" checksum="0FE2F5A00CF02CC8" modified="2018-07-18" version="1">MEDMRFRPQQPPRSESSINPLVSPPRGAALIPQQSPANHDMRSSLPRRFTTDPGLLQTLSSMSSLATPSRAVDVDYNNALHKVQLIEKKKQEYERIREQRRRFEVEMQKLDQQQRREALELAQMEEEVNRFAGHQSEPTTPPEYRNANTNNGFPGIFSRPNRYSTSSLTSPPDLSNRPSRSGSLLTSPAGTGAFQQRFGFDDNQMPSRSVPTTRRNSDDDDKEEAVRQDPSSHRSTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUY2</accession>
    <name>A0A2T4BUY2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_142082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUY2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="11847" checksum="4085D7D9AFEB4F40" modified="2018-07-18" version="1">MSSASLNVASASICVTATCASSSGYYSAICSVKAITNPPNLSRQGANLVAPLVPTANVLLFFIIFPLFITCTIFPSLTFSLALLLSLLYSRPSLLSSLPALYLSSFHPWSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVE8</accession>
    <name>A0A2T4BVE8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1362593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVE8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVE8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="604"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="732" mass="81364" checksum="15B8183D5317BBD0" modified="2018-07-18" version="1">MSGRPLLLIPSQSASPSNQPNSPNGRPATWSWSAQRKMARLYLFTTLPVDKIRAIINALSPDRTIKQSSANKRLQLLFDKEPRWLHPRDEDDMERRVTELANSPVQLRLAAEAQFPSTHQGLEQSPLCGGSDFLGSSWGAPSRPSSASPSDACSGSTFFGSDAVFESQAPLYCFPNDIMPEEGISQGWRSRDDGADARPCDKRFAHFLRQTTSLTDSSANTTGTFREHLRGYAEPYVKVVKRLVKRFTSLSLDRQGMSRQHSVRVVWDEDWISDPDATDLFLRDISLPGSLLYLNRSAPFGCDPGMMPTWEDGASRHQRHFDWTTFRGPSPRAAAFPLAPLTQEDVHRRDSHQHTVLHFLAAHGKFQALYAALSSGAVTDIINIQNTAGQTFMHLIRDDEDELSDAGLSQLIEAARALGFNMLARDCFGRSSLHSLTMLGKTVHPKCLHGLDAREYLQRDAFGFIPPVGPCATEQPIYLNAVRERVLGIDPNRVPDRAMDPGRSDCPAISRDSQLLQNVRVSMLNPFHEDRCGNNGLHCLAMAPLSVGSLAERHDLDIPLETGDFGVPTHQEAVDSSEQRLRLRYETLQTLLDAGQDPNHRNVFGNTPLMAFVAALPEEDEYKLGPAILQLLISRGADVNARNKKGETALHVAVRFHRKLAAKALVMAGANVDVRNSDDRSLLDVCDAHIPSEPKEYAKYLACRAWLSGPARAQQSPSFWEEWRVKGRVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWB6</accession>
    <name>A0A2T4BWB6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1339346</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWB6"/>
    <dbReference type="STRING" id="983965.A0A2T4BWB6"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="14">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB73612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="362" mass="38695" checksum="6F4695D0660063D2" modified="2018-07-18" version="1">MATQSPRKKCGVLGCTGSVGQRFILLLQGHPTLDLHAIGASSRSAGKKYKDAVRWKQASPMGEVADLVVRECRPEEFADCDVVFSGLDSDVAGEIEMAFLKAEIPVFSNAKNYRRDPLVPLVVPTVNLPHLDLIPHQRSVHGLSKGFLVCNSNCAVIGLVIPFAALQAAFGPISDVSIVTMQAVSGAGYPGVSSMDIMDNVVPFISGEEDKLETEARKILGGIDDARTGFVEQQALRVSASCNRVPVMDGHTACVSLRFARQPPPSPEECKAALRAYVSEAQKIGCPSAPNPPIKVFDEDDRPQPRLDRDLGRGYTVSVGRVRADDSGLFDLKFVALSHNTVIGAAGSSILNAEAAILKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWG1</accession>
    <name>A0A2T4BWG1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1404623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWG1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="170" mass="19104" checksum="8D82165F62224042" modified="2018-07-18" version="1">MRDSTNWTSPAVNLFQYLCQSNAHTPSSPFPPLLNPGTHPFIRVDRRSWLLVDTPCISSCPFTGTASRSAPSGGVCRDFDRAKEGTDTSPNTFTVHIYRPLVRSSLTWQFHYGMHTTAVEDHDHVTQPPWKEAEASGAKPLCFLHLHHHRLSIWFPGVVFLLASPRAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWJ9</accession>
    <name>A0A2T4BWJ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caffeine-induced death protein Cid2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1360441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWJ9"/>
    <dbReference type="STRING" id="983965.A0A2T4BWJ9"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21737" checksum="5383AB00F6ADBD65" modified="2018-07-18" version="1">MSQPSEQPRLTPQFCFSFGTVRDFLRLSRASIDDSITQNLNALVTPARTGFDPNSTSRRTPRSFTEQIDPEACQKFKDEVLFPSWKARADVLSYCGIVATSPDPSDPEAAVIALETQKNRERIVDERLDPYSGRFFPREPRTQSLALLMRQERAVENIVRSRTWDVIQGRCGASGQSWQDAMGDWEAQKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWR1</accession>
    <name>A0A2T4BWR1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_346097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWR1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWR1"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015431546" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB73695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="15549" checksum="42CC5C75E6D9DCE2" modified="2018-07-18" version="1">MHSTLVFLLGLAILGSASPLAGVAPSNSTSSRLNNVVTINVANKTLAAATNSTMNLPAAAAPLEDPPANPPSINDLPPCCVPCVTEGIQKETQCALEDVACICENKTKIGKAAKDCVVEACGLNTAIKLVGPAVKKLCDMDDDDMEAWAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXC1</accession>
    <name>A0A2T4BXC1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1471971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXC1"/>
    <dbReference type="STRING" id="983965.A0A2T4BXC1"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015499817" evidence="2">
        <location>
            <begin position="20"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="596" mass="62806" checksum="9FB6114299BF019D" modified="2018-07-18" version="1">MRAPASLFVVSVLSPLALSAVLSPLQRRAVAGQGWSLQSSTCPSGTQSCGNGSCCPSTSHCQATGNGEVTACCPTTSNCRGSVEGAPTCASPAWSLWTGSFGNGFCCEVGLTGAFVNGGSVAGICVTSVPSGYSTASLVTKGTGSPVTSVPASSTTTSSARTTIRSTSTKSTLSSGPTSTTVPRAVFAHYMVGSMTPDEAVKDVKDAKAVGFDAFALNTHDITSSWALNALQYLFDAADRNGFKLFISFDMSWRTITPSQIPSFLLNYISRPSYYTIGGRPFVSTYDGGFIANSDWVSGFQQPLISQGINPYFVPSFGDWSGWPNNFFSSYPSADGVFSWESAWPDPGTTISNVSDVVDQNLAQQARAANKVFMMPLSSFQFKYLGPGQDWYRIGEVNLPQRFEQILALKPDLVELITWNDAGEGHYVGNFFAEQIAGSPISDYANGFDHTGWQQLVTPFIKAYKSGTATSGSQILPSGSAPVGSLWYRTLLTSASCSSSIQNYQQGQDMVNYAVILPSSGYTIKVYSNNRLIGSFAGSTGLNYGAVPGLSVGGGQYIQVVNSAGSVVASATGTKQVAAQSSNSVCNWNYEVVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXP9</accession>
    <name>A0A2T4BXP9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_127932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXP9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015737832" evidence="1">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="23415" checksum="F211EE9596387380" modified="2018-07-18" version="1">MGNRRLIFFCLSLVAFLGEEAPSQTIFLSFSASPLSLSRPSPLSAPLESFGVTISLLPRGHPPLDKHLMDTNQADGSMAIHSVIRCIAASLGKARRSSQEDFFCGAGQRKTSLSRAVRFKAESARPTGVRRSSWTADGNWDPPSMQLVAVQKIGPGSLDWSNGSRPERANAGSVTVWLTESRDAMERSGCGRGRATWATKRFSTRWDRWNSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXS5</accession>
    <name>A0A2T4BXS5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1337556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXS5"/>
    <dbReference type="STRING" id="983965.A0A2T4BXS5"/>
    <dbReference type="OrthoDB" id="5422958at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="361"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="623" mass="66272" checksum="055405B23BDBE8A5" modified="2018-07-18" version="1">MSSQPPPPPGVTASVATASSSSSASASVSASAASTSPPPPLAALLAASASSASASTSTSAYLASPASPRQLSSSPHSSTASTSDTVTYATYYSASSSSIAAAAATSAAASAATYSHDQLRLLSLPSHDAIDPTAAISLGHRHPSSSLEDTITASLPAFAVPEAISSAADPDTAMIFSDFYKGARSPLARLRSHNSQSQQQPSADSPPWLAAEYEDLLSKDKYRQKDAIKRYLAAKVKTSWDFTWSSSRKPERKAAEVPSSTQSQKNGPVQEAEAEAIRVDSAKDIRDEADEDVELAVSNNDLSEALSDHGDIDDDNDDDTDSVYSVVSEDPVHYRPRMDWYSDLSDDEAAITSLDKLQATDNVTKISILEKRALRRRAARDEMAWNEGLACFEARRNAWTGAKTVRVRSKPAPSPPVSPRSPRRFFFRRSISGSPPSPTLINPSSPSGSQSGAISDSSSIAKDDRDLKAQSSRDSDRTADRLLPVETLLPIPHPILPPNNSFRASITPSIYLSLYDKVILNNLQPSCPINLADMIRACVTGWKRDGEWPPRPSAPEPSVVAMRRKKAKKASTANGSSVGSTARRLSFGLLGRDKDDDFHAGTGIRRSISKALGLGAQPDGSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXU8</accession>
    <name>A0A2T4BXU8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_109129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXU8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="16688" checksum="96723416A733E744" modified="2018-07-18" version="1">MQRSVARLLAGRQRCRPYSGSLALSLWPEAVQAGRICGMVTQARRHHACAESLLRPPHACASLCYPRFTAADATSARAADQTNRLATGGRGSSEAAGQLVDPDRRSAEWRSISQQARGPCRAATRIASVHTKHWWRRMAKQMRQSVLIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXV7</accession>
    <name>A0A2T4BXV7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1338042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXV7"/>
    <dbReference type="OrthoDB" id="4739627at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="11142" checksum="BAC93FE66639DB6A" modified="2018-07-18" version="1">MCRLVIFSGTCTKCGEEQIWEELSQELSCLQAKNNGTFGDCSNGVFEERHPFDQECDRCTEEDEGVGDVGEEAEAAQTLASQSKRLAEDEPSTSSRKKAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYH3</accession>
    <name>A0A2T4BYH3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Replication factor C subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1337705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BYH3"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="65"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="357" mass="39586" checksum="958FC490E7E09DF3" modified="2018-07-18" version="1">MPAAKPEERGESSNATSKAALAASSNGSPNYELPWVEKYRPVFLDDVVGNTETIERLKIIAKEGNMPHVIISGMPGIGKTTSVLCLARQLLGESYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPPGRHKLVILDEADSMTSGAQQALRRTMEIYSNTTRFAFACNQSNKIIEPLQSRCAILRYAKLTDEQVVKRLLQIIEAEKVEYSDDGLAALVFSAEGDMRQAINNLQSTWAGFGFVSGDNVFKVVDSPHPIKVQAMLKACYEGNVDSALDTLRELWDLGYSSHDIISTMFKVTKTMPTLSEHSKLEFIKEIGFTHMKILEGVQTLLQLSGCVARLCKLNMDPKRFKPQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ79</accession>
    <name>A0A2T4BZ79_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1444906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ79"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ79"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22089">
        <property type="entry name" value="F-box_FBXO9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="230"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="328" mass="35836" checksum="E98EFE9404075939" modified="2018-07-18" version="1">MASEGREQMSNSDLESFRQQWISDLRSRKESVGSASHEAGRSSSSSAANPPVASRPRKHTGPSSPAAATKTLPAIEDDEYYLHGQTFDTLPPPSSGGHLLSDAPGKHDEKPLVSALDHYEKAMEKEAQGNMGESLRLYRQAYRLDHRVDKSYREKHFPGGFSSTKGTGVGAGAGAGASKPSSEAAKTAASKPLEGEGKSQPLTWDELIESFQGLKIEAAPPIIENTPPPPCHIARLPDELLVHILTDVAVADVGDFARLSLVCKHFAYLVATEQRIWKRVCLGTEYANKIVWRSFCSHNKLTGDWAEFQLKNDKPFFFSRVKSYGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZN1</accession>
    <name>A0A2T4BZN1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1336746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZN1"/>
    <dbReference type="STRING" id="983965.A0A2T4BZN1"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="17897" checksum="C2464717BF544234" modified="2018-07-18" version="1">MSGQSSAAQHPILYWVNKRPYCDEFLRRVCKWFNLVIFTASVQEYADPVIDWLETERKFFSARYYRQHCTYRQGAYIKDLSAVEPDLSKVMILDNSPLSYLFHEDNAIPIQGWINDPTDGDLMHLVPLLEGLQYVHDVRALLGLRSGEYGHLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C085</accession>
    <name>A0A2T4C085_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_56084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C085"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="535" mass="59743" checksum="DCA63E40F88B1F45" modified="2018-07-18" version="1">MEKHEGTAFSGQDGRSVEKEKGGLVHIDVTRDITRAEHELGFWQAMRQYPTATFWAMFFSIAVIMSGYDGQIIFSFYALPAFQKRYGNLVDGSYEIPAPWQTALGMGNPIGQVLGALASGYPMERFGRRWTLAVCCVWSIGFVFVQFFATSLPMLCAGEILGGLAYGFYVVIAPTYASEICPLALRGLLTAFINLAFVIGQFIAQGVAAGLEGREDEWAYKAPFALQWLWPVVILVGLPFAPESPYWLVRQGRREDARSALVKLSSSKNAPDIDQVLLGVEQTDLLEQEFEATTNYWDLFKGVNRVRTEITIMVYLIQVIAGNPLIGYANYFFEQAGLDPSDAFDMGVGNTALGFVGTITSWFLLNYFKLGRRTIYTTGMWVMTLLLFIIGFLSIPTHNTGAIWAMASCMDIWTFIYQMTVGPICFVIISEISSTRLRTKSIAVSTAVQSFFNIVSTIAMPYMLNSDQANWGGKAGFLFGGISFFCAIWCHFRLPESQGRTFEELDILFQRKIPLIDFKTYDLLLETGVEKTTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0B4</accession>
    <name>A0A2T4C0B4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1423125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0B4"/>
    <dbReference type="OrthoDB" id="4890398at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="226" mass="25164" checksum="20F87BBA6A01A2CF" modified="2018-07-18" version="1">MDLPPPIVIGLDGLIKHSLPRINQIRSTAAAMTNFARLSPFLKRLQVSVLLLGTIYRKLSQYDTVPGSDMCIGICHDGLVQTQGMIEAVLRDEDENVYNVGKGTLIEKLPEEINSFISSVELLRSTYHEAQAEFMFRSMKELTDLRRDYSQHLHECTQLQTKQQKPAIAEASSEDEQISSSDNGTSLTEPEMPSPGASPGRKLVEHKKTHVVKPGQGQPRHQDDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0E8</accession>
    <name>A0A2T4C0E8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1742-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_5541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0E8"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="194" mass="22809" checksum="C50FA25FF2393246" modified="2018-07-18" version="1">MAAPFPNLYTHRKVAESAAKGCDVCYKPSTSVLITPDKKDFFYICSAHLKDRYFCTPKIDEDAVKAKREKELAEEKERLVKEYQEKLRKKKEKEKEKEKEKEKDKEKDKNKEKDEKKDKGKEEKESKDEAESSAKDGGDETPKPEDEPRVFELKSSFYQQRLQRKRQAEAAKRDRERASQPNYFPSVPTEPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0I0</accession>
    <name>A0A2T4C0I0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1268712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0I0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="236" mass="26769" checksum="C71AF168603DB66E" modified="2018-07-18" version="1">MPASHPLHVHDKVHLYPLIRPSAHPHLTHYSANNKSRQNAEYTREKPNSGSDTTRSKTEPDNSPHSLEAYKGIATSRYIQTSKAPTNQGHFHTLPYLSLDTLSCRFKVLPRREAHLPSVPLQSSPPPHVTHTNPRPHTPIPTLPTPKPMEQQQHTSHSDQALKKARKVKLQTGENPVLFSRFLSTQSKPHRSLSNAHLFFSFYHSLSLCFSLCSPMCMIMLFLFPSLQIPPIRHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0Q8</accession>
    <name>A0A2T4C0Q8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1379128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4894031at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="384"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="872"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1350" mass="151354" checksum="C6640353E1EB94FB" modified="2018-07-18" version="1">MSLLQIGPILIQAAITSLVRLWLWLYARGRPSLALKERPLDLQDRSTHKRRARQPLEILYPGLNSNSGDKSEFECTIIAVHGLGSNVDWSWTWKDAGKCVNWLQDLDMLPAKVPKSRIVAYNYESKWDSDAPKTRLQLCGEELIHSIHSLQRGDPSHPILLIGHSLGGNVIVNGLLYANFEDAFKYLLKATVGLVFLGTPFRGTKWQPFLESLVNLKAFAGSHNGIPRELGFDEPILLDKLHGFCRLLNKLSIPASCFSELYETDYGRRYGIKGAVKGMVVPEASACIPGVNRHALQTDHLKINKYCSPTDRSFLAVSATISEMYANAKDIIRRRQAPKKIITDRSHVLEQKPEAEACLRDLFLTDPRDDRIALKRKKGDRAQGTCEWIIGTEQITAWLGFTQKVPSDGQTNNILWLHGHPGTGKSTMAIFLTEELPKVFSETDGKTLAYFFCDSNFDKQRSAVSIIRGLLLQLIQQHPQLLDYLMPRYRERGAKLFDSFDALWEIFMTVAADQSTGEKYCIIDALDECDRESQEVLLRQLQDTFDGDQDTNLHFLITSRPYPEIQDYLGQFPNTDLASFPNATQDIETCIEAKLAQLSRRKHYTQKLKDQIRDLLRYKAEGTFLWIGLACKELETVPSKDALKLLQDMPKGLHSLYQRLLDAALAQSPEPSIIKRILSFVVVALRPLSVDELSTSCELHQDETDMETRLQFTREHVDSCRLMVKIQDDKILLLHQSVKDFLTGAGSGCFINTLDANADVACRCVDLLVDDFHQVIDPDEDLVSYAIRSWFIHARNAQSRFQVRDSHIEFFKLESRCRDRWLWRIQSTTPDIIPQEMSLLHVAGFWGIPGLVDYIASHHHPDFEQMMSSLSSGATPVNLAIYSGYTDVVTKLFRLGATLTSGAAQFAMESRHARIDMLQLLFDLKGSQLVISEGAVCSAAAHKEHGDKFIKLLLSQRGHEIRVTERMLDFAVSNSKKNNDVLPMLIGQLDATINIGERTMANIVQKCTGQVVALLLDRQGHRIRITQSVAKAAAGNVSHGEEAMALLLKRRGAEIEITEEIVITAARCENGHRVLGLLLKERGHEVVITDNVVKAAAGNSHGEQSLALLIRERGNEVVISDDIVKAAARHSNGHALALLLKHWGDEIIITEEIMKIAAGDNTLHGFEVVSLLLRERGDEIRITEEIVKAAIKSCHTKENVLELLLDLRGDEIVITEEILNFAATNTHGQRDKAATILLERRGDEITITEKLVKEAMGLLGGHKVLAVLLERRSEIAITEELIVAAVSNGIYGMENISVLLEKRGKEVVITEGVMEAAGKGFRGGRIIALILDWLGEEKAKPFEHYRERNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C106</accession>
    <name>A0A2T4C106_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_339872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C106"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="82" mass="8773" checksum="99BDC5B04B41E80C" modified="2018-07-18" version="1">MLVENRQTGKTFDSISNDKWKSLVLLALMPRQEDRPHRGSKSGPWDDGMASTGQKECLPLVSIGLDSRKGAVGGSGCKVGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C185</accession>
    <name>A0A2T4C185_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1431835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C185"/>
    <dbReference type="STRING" id="983965.A0A2T4C185"/>
    <dbReference type="OrthoDB" id="3166386at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="569" mass="64137" checksum="4C8CB5C46414DF4F" modified="2018-07-18" version="1">MSDNGKSATDIITYIGVPLAVLGVLPILYNTFATLASLSRIKRMLRRSRLTALTRSDVVNRVIEIDLPRYAVMPLDRFRNRSEYWTLSRHPSAIPGGSWTTFNWKTHAIGMKTQRVEYADQVRQPQVEVAFDELVSYLLDLGAVPDPHGWKLLRSTGLWAPVGCSLMMSPDGREKALTIAPLDDSDGHLSLAVAWSSEWITRDHGHLPPYWVRLPSPVGKQGERPASSDGNSHKKTGKMVGDADEEGQAQNGTSNEVAASLDEEDHVQRQVEANVESDITCEISLSGLVTALVPGHFDGSTAPESLYIEHLRIQSRKSNGVWFASAATAYGTSSQTILWNYKIPDDILSFSRKETVPCGVLVLLGVVDESETPEWATKHQDYGASLDQFAQRSREQRLAVEAESRMAPAQREQAARDRTRREMEQRMHDMRDKMRTEQQRRDQRAMEALQSPRWDTKLVANYCLEWLKARKLWDENLTLKEIVGFMLHRMVRDGEYTSTLCSMLDTWKAWADMGGMKKSDFQAIQDNQAVFAEATLLIALIEDTSDALEGTLAMDLQECLRIWRKVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1B9</accession>
    <name>A0A2T4C1B9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1439840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1B9"/>
    <dbReference type="STRING" id="983965.A0A2T4C1B9"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000005">
        <property type="entry name" value="Gtr1 g domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="401" mass="45311" checksum="4CCB683E633C46AF" modified="2018-07-18" version="1">MSLSPPIHDSPAAKQRADLEALVHRRSPQRSGVMSPARLKLQHLYDQSTQGPIKKGSLKPADAPGSVPEKGKPRLLLMGQRRSGKSSISSVVFHKLAPNETLFLESTARIQKDTMASFMDFQVWDFPGQIDVFDNPSFDMEAIFGEIGALIWVIDAQDDYLEAVARLNATILSLQRTYPNINIEVFIHKVDGLSDDYKLDIQRDITIRIQDELSDHGFENAPVTFHLTSIYNHSIFEAFSKVIQKLVPRLGTLESMLTNLCRTCRFEKAYLFDVLSKIYIATDTATADMASYEICSDYIDVIIDITEIYGTWQRSDDSRKRLEGEPINTKLEDQVACPTAESCLVLHDSHKPIMLREVDRYLALVAIMTDDSYDRMPLVNMNVEAVVEGLTEFFDITKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1H2</accession>
    <name>A0A2T4C1H2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1463871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1H2"/>
    <dbReference type="STRING" id="983965.A0A2T4C1H2"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015606574" evidence="8">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="267" mass="29625" checksum="470934AF9EE2644D" modified="2018-07-18" version="1">MASKIVFASLIALSAATEGLRPYEAPGPDDLRSPCPMLNTLANHNYLPHNGRNITAQQLTDAVIEAINLDGSAVSKIARDFMKAVNKSAIDLPELNRPGIIQHIASLTRDDVTDVDSLECAASPERIKHLLEDSSTDCLTVSSLAKTRLYVEALSAPQELTLKESFFTYFEASLLLLMMNDGPIPSGWSFPSPDSYCAPKNRVEIWLTEERFPDELGWERSERKLGIVDFVPAMKGVFEQKRLQAGKGPLWKMFVPSFLQQQTQSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1U4</accession>
    <name>A0A2T4C1U4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1256649</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C1U4"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057211">
        <property type="entry name" value="DUF7889"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25417">
        <property type="entry name" value="DUF7889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1105"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1164"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1207"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1392"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1435"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1493"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1588"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="567"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1701" mass="189369" checksum="0BA86CFB45E60422" modified="2018-07-18" version="1">MEADSDAGSAAQHRDSTRHDDGVGAANEPGISICRICRGEGSQAEPLFYPCKCSGSIKYVHQDCLMEWLSHSQKKYCELCKTPFRFTKLYSPDMPQSLPVHIFVQHMAKYLLRNLLVWLRAAVAISVWAFWLPYFMRAFWSFMFRISDEGLATSSIMARINETNNTLSAIPSSILAIGTCPASPLLNATTTSVAEVEAVVGHLQGKDVSDYLVRFFLGSFTSPLLASDGDLEQVANTSAVPGYAGQSTITSTLLGNVAFIGNLTRSANLNRAIVSVLEGQVITVLVIISFILIILVRDYVVQQQPEINMRAAFAAPENEFPLPPPPPPPDAAQPPQPLPPNLHVAGSDEETLEDNDAMDEQAWRAIPAVMVGPADSLTPGSSNQSMLDHDHDHDPFPTSSTTSMQNDQLNSHAQEGADDGEVAEERATVEDYLRIYRRANGDFAEILRIIEEEGLQEKLKYWVEVTRRSTVDNAEHAAADEAAGEPVADEDSHHEYDVDSDHETLQSPSNWKGKEPAWSPTPADTDISGPSVADSFGQSFPIIDLRPRSMSDGLQEQMSVNPLVNDSWSFDLLPPDAQHETPSFDEEQPEHDDTEEQTSSQPEEHDEDSHLNRENYRRLPDRDIYRRYPEPEVYQRHPQPEHRLEPEAFPRHPPDIDVYHRHPAADAEVDGQPPHINDAAEEAAINDQDAPVAGLINRVADFMWGNLNEPGARGGPAAAPEAAPEAEGDAAQRAAGIGQDAAPVDDGWVDVPDEANGEDVDGIAADGNAAAFDADAIDDLEDFEGVMELIGMRGPIAGLFQNAIFCAIIVAVTIFACIFLPYNIGRVSVWLLASPTRVVRMLFEFSKLLQDVTFLVGGLSSWCGLNVVDMFASVIGGSAKAHVVSARKISWALWTGAGSRLSRSLFLEFFPMTTMEIHNFSAVSHEALNTVKGNILSVFSNIGDSLTAARAMGFANIVYTSFTTLDEMVRKFALLATKPNLWVIDLSMPEKWPAADPQLTHWSSLDRFWAILAGYATVFMIGALYLKKGSPFSRSTTIHAWEAGVIDFLQQASGIIKVILIISIEMLVFPLYCGLLLDVALLPLFEDATLTGRIMFTCKYPLTSVFVHWFVGTGYMFHFALFVSMCRKIMRPGVLYFIRDPDDPEFHPVRDVLERNLTTQLRKILFSAFVYGALVIVCLGGVVWGLSFAMPGVLPIHYSSNEPVLEFPIDLLFYNFLMPLVVKFFRPSDALHTMYTWWFRKCARGLRLTYFLFGERKIDEEGTLRLRPGAKDTRLLKSPYLLELGEGDQVVPKTWRDTFEGGNLKPNTVMNSEQRRELRRRKARLVESQQLIKDGQFVRAPASDRIKVPKGQRVFLTVSERNHRKDGRADDDIYSTNQYLMVYVPPYFRARVLLFIFFIWLFASVTGVGFTIIPLILGRRIFKLLIPSYVRTNDIYAFSIGVYLLGSAAYFAFHYPTIRKTVRKWVRQARRDVADGRAWRRGMAMGVRLAKIFYAYFVLVIVFPLLTSTLMELYVTIPLHTYMYPPKAISTLGGEEVERHTVRVIQSWVLGLLYLKLGSQLITSLFPDSRAARAVRSIMRRGWLRPDVRLLTRAFVIPGLLAFSVAVFGPPVVAGLVIRHGGLAGGSAGEDAAEAIRIAVIYRQSYPVAAFAAMLARHAIGLVKVTNRWAAGVRDEAYLIGERLHNFGSRTSGTKRVRAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2R6</accession>
    <name>A0A2T4C2R6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cnl2/NKP2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2R6"/>
    <dbReference type="STRING" id="983965.A0A2T4C2R6"/>
    <dbReference type="OrthoDB" id="2311687at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20671" checksum="856C3CC3DFF3A619" modified="2018-07-18" version="1">MPPTESDILTNYLLQPAPLPSIITFNQFVLLFPRQLHNAPQLRSLYRDLQAQRNSVIDAVSANIEDEVKRGAVMRKEVLRLKREAEREDLDGEVEMERALFGHESGLKSATHSIHSVIPELEGAVGALEAEIQRLEQEEATLQESIQQTIGGLSDLRYGKLANGKLRDEIVDGLKTLQEACESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C339</accession>
    <name>A0A2T4C339_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1265762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C339"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17341" checksum="E0B84041697BB07D" modified="2018-07-18" version="1">MSPSGLVLDSSRVQRKQGFWSARALRPQDGNGAKHSKSTVVVGEQAAAGRESPSVARRAKPQGRRRWESWEIVPASPPLFALRVRGEINCPGGVVFYNGTSRTVPRPPQARLVGSISGIVVEGEAKKWNKGGLLLLVENHCLFVVPWRRLVRITQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C346</accession>
    <name>A0A2T4C346_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1264465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C346"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="180" mass="20193" checksum="AB0FD1481D8C07B7" modified="2018-07-18" version="1">MHAFLHVPALTESRLRGLDARARRARRATLALGWVKPCLPLTARAVHSVRRADRAIPAARILPGSWSVRWAWGQLPAIVAMTCLPSSDPGPGHYINAAVMDKPRTFIQYCTSKTSKEDQRYVTILGSHRKCNSHQRVLFPLTLHPIFFSTLTTLTGVRFNILFTLSTPRATRSLPHHRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3D4</accession>
    <name>A0A2T4C3D4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1470177</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3D4"/>
    <dbReference type="STRING" id="983965.A0A2T4C3D4"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22474">
        <property type="entry name" value="KH-I_PRP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="622"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="831"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="957"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="974"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1057"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="997"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB76077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1220" mass="134811" checksum="51DA07FF18B134AD" modified="2018-07-18" version="1">MARPRDSRSPSPAGSHFNSRRHRKDDDRRDARDRRDDGRDARRRSRSRSPDYRYRDRDRGRDVRDRGGRDRDSFRRRDRSLDRRDDDFYRGGPRDRRGPRSRERYPPRPRSPDRRRDRSRDDYRRRDDSRNRGRREGTAESQARSSRADSRSRNTPLTDSGRNGADEAQKAKSNAAQSEADKKAERLAKLEAWKRKKELEGQKQKEVNASQTRSLLAEMDKRAKEGSTALSSPVVSSAASPAPVESGSVSPTKPYTGKFDPKTIAKKSAVQRSNEPAKGALGSIDVQPPNISLPVKKGPTASALPTNRAKASSFGFGKSHADGDKLPNKRKLDMDEEVVTKRQLTKLPSLPVETDDTPYADQDEDDESDGDNFAENEEEAAAAARAAHERRLQAENEAENQAENQADTQAEAKAGDIAENSTENRADEEMKDAEVQAAKEATGEHVTNGEETANEAPADAMDVDGEEDDVDPLDAFMDGLQQTEAVKNPAKTTSVAKKKQEPEAYFSDDDFAFNDQGEQEPDAALLAIANKRKKKDIPTVDYSKLELQPIRKNFWVEPAELSNLSEAEVAELRMELDGIKVNGKDVPKPVQKWSQCGLTRQTLDVISSLGFDKPTPIQMQALPALMSGRDVVGVAKTGSGKTMAFLLPMFRHIKDQAPLKDTDGPIGLIMTPTRELATQIHRDCKPFLKMMNLRAVCAYGGAPIREQIAELKRGAEIIVCTPGRMIDLLAANQGRVTNLRRVTYVVLDEADRMFDMGFEPQVMKIFANMRPDRQTILFSATMPRLIDSLTKKVLKSPIEITVGGRSVVAKEITQIVEVREENTKFLRVLELLGELYDKDEDARTLIFVERQEKADDLLKELMQKGYPCMSIHGGKDQVDRDSTISDFKKGVVPILIATSVAARGLDVKQLKLVINYDAPNHLEDYVHRAGRTGRAGNTGTAVTFVTPEQENCAPGIAKALEQSGQPVPERLEEMRKSHREKVKSGKAKDSSGFGGKGLDRLDQEREAARLRERKTHRAEGEEDEVKEEGAKKEEDDKKVDKTLSAIRAAASSIQARETARADAADSKAAQAVHGPGDKSKDPLDKVSSAVSAINSRLGKAGQLRSGQPIDNKGPDAGAYHATLEINDFPQKARWAVTNRTNVAKILEATGTSITTKGSFYPPGKEVPPGGEPKLYILIEGDTELVVSAALTEMTRLLREGTIAAADADSRAPASGRYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3K7</accession>
    <name>A0A2T4C3K7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_314600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3K7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="17285" checksum="3497478D79208AA4" modified="2018-07-18" version="1">MPLRARWKDGFDWSKPRWLWVIRQMSDEVHGHCFEYILRWWWGEALLGIYASSPRLFSGRKEEEKEEESRKGFVLLLFSIKANISAVLVIVAALNPEPRFHIPEFFQMPPSALRSARYPAGASDGSVRCCCLISSAATHCPVLKASKVRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C473</accession>
    <name>A0A2T4C473_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C473"/>
    <dbReference type="STRING" id="983965.A0A2T4C473"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="178" mass="19341" checksum="344D74D4594EB526" modified="2018-07-18" version="1">MATWFPDPRRIVTGHNEQGKAVVVADGTVPCVPTPLGANFAVLYETHEFPASNDEWVDPTKVRTKDLANGKGVVLRVVDIPPNVDKAGMLFHRTESLDFGILFSGEVICHLDDDVEIHMKPGDVCVQRGTIHGWTNSTDKPARIYFILSAAKPVEVNGQSLTAAGYSKKDIQTGGQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Y8</accession>
    <name>A0A2T4C4Y8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1331837</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Y8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4Y8"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="49"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="894"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="442"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="800"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="850"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB76631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="943" mass="105249" checksum="BB179080A3B66651" modified="2018-07-18" version="1">MPPSAVNNNGSAAPASHSASHGAADATHASSSAKQSRSRTTIPTQSGKWILGKTIGAGSMGKVKLARKEDGSEQVACKIIPRGSTDDGHQSRAEKERADQSKEIRTAREAAIVTLLHHPHICGMRDVVRTNYHWYMLFEYVNGGQMLDYIISHGKLKEKQARKFSRQIASALDYCHRNSIVHRDLKIENILISKTGDIKIIDFGLSNLFSPRGHLKTFCGSLYFAAPELLQARAYTGPEVDVWSFGIVLYVLVCGKVPFDDQSMPALHAKIKKGLVDYPSWLSTECKHLMSRMLVTDPKQRATMQEVMNHPWMVKGFSGPPDNYLPVREPLTSDLDPEVIHAMQGFNFGSPDTIRAQLLKVIESEEYQQAVKAYQREKEQPQPIKDGEKKRGFGFDFYKRRNSNSRDTLSGPSSEALQIGIDPLNAFNPLVSIYYLVKEKQDREHAEMNPPPTTSRDKEKEKEKEQREREREREKLAGGLPDLAPPQAAHTNAATYEMPGERPTGGRTRPRARTHGEDDAPDLVKQQHVPVAPETKAEQLQKKEGTAAGLLRRFSTRKRRDPDRAERDRSHPPVVHVHSPPEAAPTAPRKSFSIRRGRRERDDQSRPALPSGGSQPQHSELLSPPMSAGGVRGSRKSGLGRSTSVNSADLRRRDNGSMSTREPPQTSGSDQSDANEQSSTVQRGLSHSQSVAMRAKSLGHARRESVQQRRLRREAAQESNVPEETDMEQEQSGVSTDRLDSAELAKPVYLKGLFSVSTTSGKSVPAIRADIRRVLKQLNVDYIEIRGGFSCKYTPSIDLNRVHDTPGSPPAQNPGHRRRFSFGGLMRGEDRDRDDIRDIERSAAAPRTPGRQDRDRNRDHSYSNSEESVDSIPRRSGGASRRVPGETTTQVQSDLGGSMVMEFEIFIVKVPLLSLHGIQFKRMTGNTWQYKNMAEQILKELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C528</accession>
    <name>A0A2T4C528_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1332408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C528"/>
    <dbReference type="STRING" id="983965.A0A2T4C528"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015432472" evidence="1">
        <location>
            <begin position="28"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="296"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="798" mass="87940" checksum="7B8ADA59BAFD1F82" modified="2018-07-18" version="1">MRTRANPRLVLTLSLAVFLSSPSPANAAAAAAAAQKPSNGLSYVNPLIGTTNGGNVFAGATLPYGLAKASADVDGQNTGGFGLDGSNVVGFSSVHDSGTGGNPSLGNFPLFPQVCPDDGDINSCRFRIGDRKLHYVNDSVTARPGYFGLKLESGVAANMTVSQHAALYRFTFPQDAEAKAKHPLILLDLTDLWQSRQNASIQVDERTGRMTGNGTFLPSFGAGSYVMHFCADFFGPDVHETGVWVNSRAGTEPKHVFLTRGFNLFYLEGGGFVRVKPPGDGVVTVRMGISYISSEQACRSAEREIPDPLTDFERLVDEAQRAWTEKLSPIAVKSGGATEDLMTSFWSGVYRNMISPQNYTGENPLWKSDRPYFDSFYCIWDSFRVQHPLLTILDPHAQTQMVEALLDIYKHEGWMPDCRMSLCKGWTQGGSNADVVIADAFAKNLSTTIDWELALEAVMADAENEPQEWSYHGRGGLHSWKTLDYIPYLDFDPYGFGTNSRSISRTLEYAYDDYCLSELAGGLGRRDLQAKYQKRSMNWKKLWKADQTSLINGTDTGFRGFFQPRYQNGTWGFQDPIACSALAGFCSLTTNPSETFEASIWQYLFYVPHSVSSLISLLGGDDAMISRLDFFHTSGLADISNEPVFFTVFLYHYTGRPGLSTKRIHQYVPADFNSSPGGLPGNDDSGAMGAFLVFSVMGLFPVAGQNVYLISPPFVEEVSVRHPVTGKTATVRNVGFDASYERIYVQSARVNGRPWTRSWIGHEFFTEGWTLELVLGTEESDWGRDVKDRPPSWSGDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C548</accession>
    <name>A0A2T4C548_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1438466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C548"/>
    <dbReference type="STRING" id="983965.A0A2T4C548"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="134" mass="14165" checksum="B767992D564A96CC" modified="2018-07-18" version="1">MRAIDDLTKANFCESVEAGHSSHGDQAAISQKLGITAPSVRMDSQAKYGSIARGAGDIYLRLPVSATYQEKIWDHAAGDLIVREAGGQVTDVHGKRLDFSVGRTLANNKGVVAAPLAVHGKVLEAVQEVLSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5A9</accession>
    <name>A0A2T4C5A9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1331831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5A9"/>
    <dbReference type="STRING" id="983965.A0A2T4C5A9"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015574385" evidence="1">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="174"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="402" mass="41753" checksum="D70E1B0269F0DB49" modified="2018-07-18" version="1">MLSKSFLTLAALLVSAVSADPRELGTVLAGNKDLSTYYSLIKKYPEVLLQLPSYAGVTIIAPSNEAFKNIPYTALNGIWDPDDKATTVPLLQYHVLLGTVATAGLDTGPTYVRSTLLTSPRYTNVTFGQNVLIAKQPGDTVVFTTSMGTRCTLVEGDIAFQGGLVQVVDNLLIPPSRIENTTKAFNVPNFLGGLYAAKLMPKISDEKNVTVFAPVDGAFASVGGSLKHLDARALARVMGYHVVPNQVLVSSALTNGTRLETLAKNAAGTAPEALVVRQAGNNKYVNSAQIVQPDILLANGIMHLISGVLNPDAEAAAPNPTAPTQAAVFPVSTARNPFTSALPCTVSCPVPTTAYNTTAEATATSTTSVFTSRSKGVAGALATANIHAAGAALGLLGAGMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5L6</accession>
    <name>A0A2T4C5L6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAVE subunit 2/Rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1355101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5L6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5L6"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38656" checksum="C8DFBBB311053279" modified="2018-07-18" version="1" fragment="single">MSLDIWPPVSPEELAIKVAETQRRELAWIVERTLEICDELKHGLEDCYALLAPVDPGSTLVMSTPRNERVKGTITRVGTRIVKGIRLLTHSFTRAAQKTLGLQFKTIPPQALTLSHSVPIHIHALDTVHTHLNESIDLLGLLVANSKPSNPSAADTPTVNSTAQSLSSGLRLLADSIAASIALLKGPPINEPDARWTTQSCPPGHFSPPLMPNFSLYITLQECSIVLVLRALEPVDAPVHFGTKLGLAIGTYRRLEHDEADIVFKWKPGGDDLSDTKRVSANHTVEPPAASRKLSDSQLEEVYVREKVRVESADPSLISLYSKLGYLSIMLEQARCNLDAVMSVQLKMYTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5M9</accession>
    <name>A0A2T4C5M9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1237197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5M9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="17558" checksum="AA20D5BAEA81A497" modified="2018-07-18" version="1">MLGIKKRSVCEEKGRGGGVGCTVSCFPFAYRNRIAASLEEGERANWGLSVCTCSQLRDLRRPASTIWFGHEETAWGRAGGKFMFESSQCLITLPTVLTPVCFASKGDSRGQRRYKQRHRSGDRSRERLPFSDASRLLGLACHCCQVSEHTSLTVFCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5T6</accession>
    <name>A0A2T4C5T6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1355184</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5T6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5T6"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="269" mass="30473" checksum="98083150FBA88287" modified="2018-07-18" version="1">MGSRPDTPNGVKSSDVVANLGFAPAVKLSGEWSVERVLEQIPDQTPVEGSSSPIPFFHMLSRLKTTKREGWRRFGIERGESISDHMYRMSLITMFAPPALAKKLDLAKCMRMALIHDMAELLVGDITPVDGVPKTEKNRREAETMDFLTKNLLRGVAGGDVGAQIRAIWQEYEDSETLDSHFVHDVDKIELMLQMVEYEKQGKGQVDLGEFAYVARKVTLPEMREWAEELLRERDAFWQNKEHVHGEKGTEGGVSAETSRGQEEYYNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C656</accession>
    <name>A0A2T4C656_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1332034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="PTB77035.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="73" mass="7822" checksum="8B5D37D2392E5475" modified="2018-07-18" version="1" fragment="single">MINDATPALLAAENGHLEVLQLLLSEGADIFLKVKTGWLPIHLAAYNGHAKIVDLLIENGSDAMVRDDDGDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C678</accession>
    <name>A0A2T4C678_TRILO</name>
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        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1316435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C678"/>
    <dbReference type="STRING" id="983965.A0A2T4C678"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="304" mass="34317" checksum="9C61DD7EBFB32D88" modified="2018-07-18" version="1" fragment="single">PAEPSSSATINLPGPAPLSLFLTNIKLLDLDQLPDWPEITAETFAASGTTLQDQKRRVQCVEWALYQLFVIWDPDEAANQAKKNGDLGRDTIIRKTMLDECKGERLEEVLAFFSTVVLRKVVSDSLAANHSYVTPVVELAFENKGYKSEKSHLIAARARFQEFARVLDDKEDEIIRRREALEIKEMDGGGQTVSDNARAEMRRTVRHNWSGSDAWMEALLCGDAKHGGLLATKFDRVWRRAQKGRIDELDTDDVGLLEQLDSRVKMQRDRLRKWDAFRRSTFGEARSTPTKPKASTAKAKGIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6R3</accession>
    <name>A0A2T4C6R3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SURF6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1390574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6R3"/>
    <dbReference type="STRING" id="983965.A0A2T4C6R3"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="352"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="575" mass="63439" checksum="4985532497D2D73B" modified="2018-07-18" version="1">MADSSLQDRLRDHAKAFDGLLSLIPAKMYYGEDTSDQWKKEKQTKQEAAAARRAKLDPDSALNRNAKEIMDERAKNKRKLREMEQDENEPEEPFEPLPGVEVEKPLEGLKRKNPDTPQKKLKTNGDAEAEGNVEAEEEAQGAEAAPKLSKKEEKRAAKREKKAEKKAEKKMKQESGEAATPAKAPAKTPVKEATETTSTPASKKQKNKKAAKEAATPSKPQPTPSKAQDADAKDADKPDETMQDRLDGLDPSLDFSSLQREDDGSAVSAPDSEVHSPTFDSTATPNDTQPTSTDPASTSTSVSSVAPSEKPKHIKIPADTTALRARLAAKIEALRAARKADGTNGKPIRTRQELIEARRAKEAQRKAHKKELRQLAKEEAQKKREEALASNSPGVMSPNISLDDAAQGGFAFGRVAFADGTQMSHDLGYFLNRGKKKGPSDPKTALLKVQHEKKRIEELDAEKRQDIEEKETWLNARRRAEGEKIRDDEALLKKAVKRKEAAKKKSEKAWKERATGVAKAQHEKQKKREENIKQRREDKLLRRSGKKKKGGAGGAKKKGGRPGFEGSFGVGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6T3</accession>
    <name>A0A2T4C6T3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1390621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6T3"/>
    <dbReference type="STRING" id="983965.A0A2T4C6T3"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="317"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="585" mass="65493" checksum="3329322DA153793C" modified="2018-07-18" version="1">MAPLRRTTRSQAKKAKKTDILVPSKPVPVTLLSGFLGSGKTTLLQHILRSDHGLRIAVVVNDIGAINVDASLIKQTHQLTKTDEKVIALQNGCICCTLRGDLLEELVRISQLQQFDYIIIESSGISEPEQVAETFDARLADQMSLMTEGDGMAGLDEDMVKVLMKLKKAGGLQKFARLDTTVTVIDAFTMMHDFDTVDLLSARRDDVTPEDERTVSDLMVDQIEFADVIILNKIDMVNEETKAQVIDLVKKLNHRAKILEAKYSKVDVKELVNTGLFDLERAQSGYGWLQDLHAMTVREVNGRNVVTPKPETEEYNVQNFIYSRLRPFHPKRLWALIYDKFILQMEQPDEDDDDGEEEDDEEDGEEDAEMVDYPDVESVGSSAGDKASSSSPAHAPSTPATAASPNHEDKDGDDEDMEADGMTPPENDVILANKRAHPTFARLFRSKGEIFMATRPHRCGEWSQAGAMLTLTGGRSWFCTLQPEEYTTGNEEVDKMVKHDIAKGGEWGDRRQELVFIGEGLDHEALEELLDGCLLTDGEYEAWKGVMRREGVTELERRELLEGLFEDGFPDWPGDDEDGHEGHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7B7</accession>
    <name>A0A2T4C7B7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1330156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7B7"/>
    <dbReference type="OrthoDB" id="3557758at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="428" mass="46807" checksum="59BCCFA44DBE4CBD" modified="2018-07-18" version="1">MRGREKDKKRRPLISAPVGPVKSSRGADLIRSERLIIVDTIDDCETASSDSTLRHHSHLPTHSLRHISDSFRSDGQLPSSPADDSCDIASTPTIKAYLESKSSKKPRRSLLSTTSSIPKPSFKTALLTVSVTAQQDENIPPASDGLFHLNPPAQRAASKLPKSRTMSALHELKTSISRPSLVARSVNTSAVGGPSAKSSPSSGGTTLTPIKLPDLKMSQPSTTSLARSTRDYTPEASTFEIINAHSSAYWTGRFMALQDRFSSENLAVDARESRLSPTDSFSIQPRTPYSSMHQRASHLPNSTTTSALRNLMTSSSNSEISEEDARARRVFDHLDSLCSTPEARRSLRIWQQAYARRHNSPYLLPEGGSMGTVEAKGFLSKLFGSSKKNGRHSFSKLQQCSFTHENRSKSFLPASLSRASRGKRLTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7K7</accession>
    <name>A0A2T4C7K7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7K7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18536" checksum="044D04A5BD679526" modified="2018-07-18" version="1">MASRYHGKGKTAKRRIYPPAKQEVSQPARRTIRRQKPRFLHSPSCCPAAPTLILTLLSLSPSSPHFVFAQKALLRRLRDSHPIVAAGPGQDRVRPARFLAHATHFLEERIHSSAYKLAPTRSLPRPPLLRVWRFSHHRSASRPLNHSAKIRPYQVVTVPSCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Y8</accession>
    <name>A0A2T4C7Y8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1375073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Y8"/>
    <dbReference type="STRING" id="983965.A0A2T4C7Y8"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="307" mass="33808" checksum="709B4EBAA5B09022" modified="2018-07-18" version="1">MGDLPTTFDQPVHIAVIGGTGLAQLDGYEPIALVNPLTPWGHPASPIAILSHNGVNIAFLARHGLHHQFAPHEVPNRANIAALRHLGVRCVIAFSAVGSLQEEIKPMDFVVPDQVIDRTKGVRPFTFFEGGLVGHVGFADPFDKKLADIVKTCAAHMKGDGVVLHDKGTIICMEGPQFSTRAESHMYRSWGGSVINMSALPEAKLAREAELSYQMICMATDYDCWHSYEDVNVEMVIKYMQANSQNAKRLVGGVLDQLSKIDHSDLVQAKHWEGYSTGSIKFMTKPAGRNPEAMKKIEYLFPGFWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C819</accession>
    <name>A0A2T4C819_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Emopamil-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1331427</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C819"/>
    <dbReference type="STRING" id="983965.A0A2T4C819"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="58"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB77674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="228" mass="25925" checksum="C4E9E77241224543" modified="2018-07-18" version="1">MADLPLHPFSPFAIELPTYVANTMSAPVLVSIFAAGCAVIFLVTYGIVQRTRPSMSGGDLAVALWFALCGCIHLFFEGYFSYNAFDMASKTDLFGQLWKEYALSDSRYMSQDAFTVCMETVTAVLWGPMSFATVYLIIADHPLRHPFQLIISLGQLYGDILYYAICTFQEVVFDVVYCRPERFYFWAYYFLCNFFWIVIPFMLIWQSARETARAFAQVKAASAGKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C882</accession>
    <name>A0A2T4C882_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1375239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C882"/>
    <dbReference type="STRING" id="983965.A0A2T4C882"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB77744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="357" mass="39762" checksum="5AC11E7E41425B39" modified="2018-07-18" version="1">MPGQVQEKPPAPEASAAAAIEDDDEPDEWDKRIFSTGCADENAKMTDCYYEKKDWRACAKEAKDQHQRLLEGGSIIMLPARRSFAVASRPLARLPIRQIQAPARLYATDSAATPSTAENASSSSSSPAPKYAKPAPKATPSKPSIAASVPSSYSDIVYQAKSIAYEDAREDDAAADLAEPVSVDWTRSFYGISARPVTEKQFKVLMQPLEEKDIEVKPDGVVYLPEIKYRRRLNEAFGPMGWGLIPKGEAVVGDSIVTREYALIVDGRFVSQAQGENTYFSADQLPSAVEGCKSNALMRCCKDLGIASELWDPHFIRWFKKNHMEEVWVEHVTTKKKRLQWYRKGDVDVAYPYKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8S2</accession>
    <name>A0A2T4C8S2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_18950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8S2"/>
    <dbReference type="STRING" id="983965.A0A2T4C8S2"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1108" mass="119689" checksum="9498BB51F99BFE80" modified="2018-07-18" version="1">MAHTTNQMILKRDLSHVPITALALSRSPSGQLLVFAGEDSDLVVYEAKTGHLKGRLISQTSVFVDQPIHGIHVRHGRVLVWGNSHVAILSVERLAEQQGDGDGGKRVIARAVAPDWIFHGAFSENDDSVGALATAHNEVIPLSFSSDTGVIHLGAAIAPSRPMLYSAHLTWISSDTVLVAGGTVFGHVVVWKCRLAGEPSTETLFNFEGHEGSIFGVDICTVTLSDGTPARILASCSDDRTIRIWDITERGGDGASRSHAPKAPQVIDTGFGGSDFKDADGAQAASRQNAPVAAAMGHASRIWGVKFGPSCGQDALSVYSFGEDATTQRWHLQLSHAALAQEAGCSSSRRLIGRLSHSKTFSLHSGKHLWSRAVLLEDKAALVASGGADSQICLIDETDLLSQGSDSLGNLLTLDTIDILKGLLDSGPSNTSAKDIISRYDFLSYDHILVSTSQGRLLLGHLKEPHAEPEWEQIEVPQDIRDDVRLCYVVKAIAPTAALLGTTSGSIYHFHLPTRRIIHVASVPGKIIEMNRLSSRDSLVEVLIYLHGRAESHYFAIDVSTGQVHNQGQTKGLDPRFVPTAAGKLNDLLVIGSRHGFLSVLDRQEDGSYHSILDIATRSRDTITAILPLPPKSGSPHASPYILVTSRDGKYRIYELDRQSGSISLHLRHETSPPFGPMIAGGWFTQDAVPELVLYGFRSKDFVIWNETRREELATIECGGAHRTFQLTFSETIPGRYRFAFTKTSKLTISSSEHLAHEWVKAGIHGREIRSLSSNGRYIATGAEDTTIRIWEYLPAADGAQAELRCVAAMKAHITGLQKVAWLGDNYLFSSAGNEEFFVWKVQSLKSDYTGLAVMCEGIFADKSVDADLRIMDFDVCRSDDGSSMVVTMGFSNSVIRTYRYTSDGGRFELLAKGRYTGACLTQTRHLSVRDQLPRLLTASTDGHLAIWRTEPQEGTSHEYVLEQAVSLHQNSIKSLDMIESGEGYQVFTGGDDNSVGVAWLGGTSGSTGGASWAFSRRSIVRRAHAAAIAGVLLIRRHSGVVGISVSNDQRVKLWSIPSDEDGNVGLIRGNCIGVADAGDIAAVGNLDSGTATIVIAGVGLEAWSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8V0</accession>
    <name>A0A2T4C8V0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="5">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">M440DRAFT_1421678</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="5"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8V0"/>
    <dbReference type="STRING" id="983965.A0A2T4C8V0"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="362"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="609"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="PTB77963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="769" mass="86332" checksum="9D9E51A01D7931E3" modified="2018-07-18" version="1">MATASDIPMDGQLPEVDSHSEERAAKRIKIDDAAAPQDQNGEAGQDTTRPLQNETEPTPEASKSSEANGEPAGRVKGMAPIKKEYLIDMSRNQDERPPTVDDDAAEGRGTNGRDQSQRDGEDSRSQGKKGKKKAKGQNTDRSFGRFDDAIPLCSSRAYSPEFSPKECRHGDSCKMCHDLRKYLREGRREDVEALGGKCPAFEAYGYCASGWKCRFVKSHMQEIEHADGRKELVLSDNRPPKAEVKETPKPKEDESAEAETSAEKGPDTEERAKSEDELRPDIYNVVTMGQKIQLNRKRLDFTKADQYIQWLNHEGGISQDFHHRRKDQPAMGLEDLRARFVDPPFKPSEKRRLYFGPETPTLAPLTTQGNLPFRRLCVELGCQATYSEMALGMPLLQGSKPDWTLMRAHKSEITPPKMNPGAIPLFDDYDNSRDLKFGAQISGSAHWVVTKAADVLNRYCPHLRLIDLNCGCPIDKVFKGGAGSALLEASGKLERMIRGMNAVSGEIPITAKIRTGVRKDRPTATQVIGKLAFGAREHRERLGAPGCAALTLHGRSREQRYTKTADWGYIGECAALIKTYNEEKARITDTIAEPDESTLPNAKDGRMYFLGNGDCFSHVDYYEHIENARVDTVMIGRGALIKPWIFEEIEKGQYLDKSSSERLGYIEKFVKYGLEAWGSDELGIGYTRRFLLEYLSFAHRYVPIGLLEHLPPRLNDRPPAYRGRDEMETLMASDNYKDWIKISEMFLGPVHPGFQFQPKHKSNAYEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8Y1</accession>
    <name>A0A2T4C8Y1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1182170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB77993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8Y1"/>
    <dbReference type="STRING" id="983965.A0A2T4C8Y1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF30">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="968" mass="106479" checksum="AB9EF3A1119A76D7" modified="2018-07-18" version="1">MGSLRNIMNVDDDHVDSHSIRRDRRPASMSSLDHDLSVPMARYHHIPVDLSRQTSPPHILHPAAPPLGYNSHPGARRRSNTSTDSMDSSYGQSQNHTAYYQGTAMRPIMPGTVSGDHPVKLTPITGRVSRAKKGVPVHTCDVCRPPKTFTRAEHLRRHQLSHQPPELSCTVSGCKKVFYRKDLLDRHLQRHGEHDGKLNRDSSRRRRSDSSPSRPYSSSPPAPSMQQASSPYSVGAAATPASSVGMVAGHWSSVNRSTPPGPALQSPHMRDTQSAYHMADMSVVDPVTAGVVATYGEARPAGLGVINPQVTDPFIPETTPSNMSWTDSSGIPSTSSGSAYSTPATASSGFQQPSARAPAAEWSGPMPSYTTSPSPVITDNGYPMSFGYAATPPQVYSSVYGDGMGTPFTGFEHSANLYSPQMLDTAVRSMSPPELMVGHSGETLVAAPAALPVDRMMYPRTCSREPIDALGLYTLMPAALSHGIRSMIPTYIEVYWDKVHSMYPIIHKPTFEDPANMPEEHMEILQCAMAAIATQFLEHEDHRANGHQLHTYAMEKAKLYANSGTPEWPLPIMQATLLCEYYARFRGRNKKAYMPSPRFEALYQMVIHAQTTYPPTMGSCDASQQWRIWVHMESKRRLLSACFLLDVHAMSFLEQPRAAVLGLDYSDPRTLPIPLSMATLQLWDAQTYQEWSSISQPAMPATVGATILETITAADIASIPAFDASLFLVAYVLQLPQRHSLTKINLLEDASSISMSHFRIIHLFPYSPIAMSHLALHYTPLHTLLSVSGDSWVFNKKVLQATDFMEHQKQLEKWRDSGSAAVAVAFASRALKLFLGLQRSKDGNTAAAASSFQQRAQQQQKQRKEISDFWGIYVCSLICWAFGHVGAAASRSKAPTRRAAVQWLLRAADMEPGRIQQMSEQERQAGSGAVGLARASLEKDCLGGRSILLADAVGVLKKLEEGDNYRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9B4</accession>
    <name>A0A2T4C9B4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_17745</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9B4"/>
    <dbReference type="STRING" id="983965.A0A2T4C9B4"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="16">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="17">
        <location>
            <begin position="516"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="805" mass="91338" checksum="B3249E02F6A1234E" modified="2018-07-18" version="1">MTSLKRAQGSDQLSQNISNKVYVRSTRSGKVQKIVREVYLRTDIPCSSNLCRACLSQAPRNAVNQALPFVLSARPAGTKSYPQGHYLVPDTNALLNAMDLFEQSSSFYDVIILQTVLEELKNRSLPLYNRLVGLTKSEDKRFYVFFNEFRLETYVNREANETVNDRNDRAVRQAVKWYGEHLAQTKATRVPAVVMLSDDRENLRKAREQGLQASSLRDYVSELEDGDRLLDLVAESQLQAQGGFKPSTQPLYPEYYSSSRMMTGVKAGLLHQGIFNVSPYNYLEGSIKVPAFPKPLLILGRENINRSIDGDLVVVELLPQDQWKSPSTKIIEEDTITKNENADTEERQDFISDKERKALQEEVKRTQRASGENQLQPTAKVVGVVKRNWRQYVGHIDPSTASKAPSQGRRLDSVFLIPMDKKIPKIRLRTRQVSELLSKRLLVTVDSWDRDSRHPVGHLVRSLGELETKAAETEALLLEWDVQYRPFPKTVLDCLPKEGHDWRVPESKEDPGWRDREDLRDLLICSIDPPGCQDIDDALHARLLPNGNYEVGVHIADVSHFVKPANAMDTEASIRGTTVYLVDKRIDMLPMLLGTDLCSLKPYVERFAFTVIWELDENADIVNVRFTKSVIKSREAFSYEQAQLRIDDASQQDDLTKGMRLLLMLSKKLKKKRMDAGALSLSSPEIKVHMESESSDPIDVKTKELLDTNSLVEEFMLFANVSVAAKIYEAFPQTAILRRHAAPPKTNFDELADQLRIKRGLELRTDSSKALADSLDKCVDPKEPFFNTLVRIMATRCMMSAESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9E7</accession>
    <name>A0A2T4C9E7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1186946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9E7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9E7"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="376" mass="42264" checksum="390826D380C95AF8" modified="2018-07-18" version="1">MADEKPSVLIIGGLGYIGRFLAQHIHKNNLASEVRIVDKVLPQLAWLAPEFSEACAQSKFMQADASKPEALVKVFDRPDGKQWDYVFNCGGETRYSQEDEVYKLRSLDLSIAVGQEAAKRKVKVFVELSTGMVYKSDSSPSKEGDKLKPWNKIAIFKLQAEEALAKIEGLNLVIVRLPHVYGPYASQWVATALCMARVYQHIEGEMKWLWSKDLRTNTAHIHDVSRALWDIAAWYDAGKPNWNESEMGKVPIFNVVDKGATTQGTMADIIGEIFKIETGFQGQLISTFAKMNLDSVVDDVNDEILGPWADLLADAGITRPGPLTPFMEKELLKDTDLSMDGSRLESVVGFKYEKPVITKELVEEVIESYKQMKWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9L2</accession>
    <name>A0A2T4C9L2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1389985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C9L2"/>
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        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
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    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
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    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="337"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB78267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="544" mass="59522" checksum="603CAFA0C5AFC61B" modified="2018-07-18" version="1">MAPHAEVSTGSSNGNGYAQRQTASPGAARSTFVVNSPNVTYTDSEIRSKYTYRTTSVETDANGNFVATPKETLYDFKVDRKVPKVGMMLVGWGGNNGTTVTAGIIANRRNLTWDTKEGVQEANYYGSVVMSSTVKLGADAKTNKEINIPFHSLLPMVHPNDLVIGGWDISSLNLAEAMDRAKVLEPALKSLVRKEMAELTPLPSIYYPDFIAANQEDRADNLIEGSKASMAHVEQIRKDIRDFKANNGLDKVVVLWTANTERYADIIDGVNDTADNLLKAIEQGHEEVSPSTVFAVACILENAPFINGSPQNTFVPGAIELAEKHNAYIGGDDFKSGQTKMKSALVDFLINAGIKLTSIASYNHLGNNDGKNLSSQKQFRSKEISKSNVVDDMVEANSILYKKGEHPDHCVVIKYMPAVGDNKRALDEYYAEIFLGGHQTISLFNICEDSLLASPLIIDLVVVAEMMTRIQWKAASNDGHETAEFKHFHSVLSVLSYMLKAPLTPPGTPVVNALAKQRAALTNIFRACVGLEPESEMTLEHKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA97</accession>
    <name>A0A2T4CA97_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1194339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA97"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="194" mass="21871" checksum="41B7E5D9EC7AD4D1" modified="2018-07-18" version="1">MKQWEQKHENVLASGMQRCCVARPFPWMLVTVHRGGLPCSISCLIQFSSAPAAPHATKSCMFCWYVTSTPLGTITTRLYRFGLSPSRGGCFQRTGLGIRFLYSSLRLVDSTYLYNRAGGPVAALEPAKRCKLVSNVHITARSRKRSRQRKDRECVRARYRSRLRATQVRSVRMDSHEVHANRLVSKHIVCGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAD1</accession>
    <name>A0A2T4CAD1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1390170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAD1"/>
    <dbReference type="STRING" id="983965.A0A2T4CAD1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="224" mass="25447" checksum="3E77C809B7461D48" modified="2018-07-18" version="1">MAQKRLMQELQSLQKEKWVDITTDEANLLKWRIGLWVVNPDSVWHGAFLKAEMKFPSDYPYQPPAFKFLTPNIIHPNVYPDGNLCISILHKPGEDEQSGELASERWNVLHGVESVLRSVLLLLDDPEINSAANVDASVLYRDKRAEYNALAKATVAATQKHIPEGAHMPTMAELTPVPVKPVEDDSDFWNMSDEEEDFGGSDSDENMEDFEDEEEEDDDDEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAI6</accession>
    <name>A0A2T4CAI6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_50778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAI6"/>
    <dbReference type="STRING" id="983965.A0A2T4CAI6"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="18"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB78587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="799" mass="89098" checksum="94BCA0DF06F9554A" modified="2018-07-18" version="1">MENLKLHNSLKPGPPVPFVPIRPGEVSWYACGPTVYDKSHLGHARNYVSTDIIRRILRDYFGFKLNFVMNITDIDDKIIIKARRQRLLELEKNKTYTKEELVKLTRTAFQAYAASSLPLLVENGSDLDETTYIARRDASYGKVLSGGTLTGEGKPGDAEAKIKMHISNMDAAAEALKDGSIFPGADEIFLPYLDSLYKETIDTRDQTMFTDLTKSMEALFMADMDALNVLRPDHITRVTEYVPQIAKFVERIVEKGFAYESEGSVYFDIAAFEKAGNSYARLRPESKNDKALQEEGEGSLSKNLGGKKGAGDFALWKKSKAGEPFWPSPWGDGRPGWHIECSVMASDILGSQMDIHSGGIDLAFPHHDNELAQSEAYFCEHGKGEHTWVNYFLHMGHLSISGSKMSKSLKNFQTIQDALATSYTPRSMRIVFLMGKWNDGVEISPDMRAQADNWESTISNFFTNTKSWLAEAGIESGLKSLDINSDKPATGLLAELEQAKKDVEAALTNSIDTPRAMLVILKLVNTTNSYLKDNKDADLAEVEAIARWITKLVGIFGLDPNAAPPYEGLGWASVISESTDPETAVKPYAAVLEKVKSDISALSLSNEAIAELLSKDPTPEFQAIAQGGSRDIEKLSLPYLRVVSQIRDELRRTVSSYDQQTKKAILQITDRIRDQDLTNLGVYLDDRPDNQPSLIKFVPAAELIAAREEKIAREAEKARKKEEARLAKEKADQEAREKAKVPPEELFKKDERYSAWDEQGIPTKLKDGSDVPKSQLKTLKKAWEKQKKIHEDLKAKGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAY6</accession>
    <name>A0A2T4CAY6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1373574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAY6"/>
    <dbReference type="STRING" id="983965.A0A2T4CAY6"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="34"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="477" mass="52558" checksum="BAF28787CE73387E" modified="2018-07-18" version="1">MASTNDQANGVPKKKLILNAFVESCSGHQSPGLWRHPQDRSANFNSIHHWVELAQLLERAHFHGIFIADVLGPYDVYKGPRNADPAIISGAQIPVNEPLVLVPAMAAATKNIGFGVTIATTYEQPYHLARRLSTVDHLSGGRVGWNIVTGYLDSAARNLGLTEQPPHDERYAIADEYVDAIYKLWQGSWRDDAVKLDAEKGIYTDPSLVRPINHKGKYYTVPGPHICQPSPQRTPVIMQAGTSKAGKAFSAKNAEAIFVAGHSPSVIAKNIAEIRAAARDEYHRDPSTIKFLAMLCPIIGKTQEEAEAKYEDYIQYGSEDGALALFGGWTGIDLAQYDDDQELRHVESNAIRSAVEAWSKASPSVPKWTKRAVAKHIQVGGLGATVIGTPEKVADEMERWVREADVDGFNIAYALMPQTFQDVIDLLLPVLRERGLFWDGYAVDGGTYRENLYAKKGLARPPADHPAAKYHWKADSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB59</accession>
    <name>A0A2T4CB59_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_269298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB59"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="303" mass="33293" checksum="5EE1730EBF5E5ECF" modified="2018-07-18" version="1">MAPLGTYSTRAVIDGTSQGSWGSSIQCPVSCKGTAYVATLPGPAITPNIPDGQALPFASPLAVTTPRGFLLHSISRQYIQLERRYGTDMFDIRQALLAGSASLLCHSAARPTSHKVRDASASGTSLSCLLIAFLDSRTWPKGFESAVAQPRWLDRWHRVTRRYVTQRLVCCCASLDRPQLLIHTSRMRLDMRGCVDACLDRGLSRRKQKRVDPFRTSCSRRLALALPTNNLTCNSTYNSTSGNISKEDKHTDRGSQDQSQEGPGLANRAEQRLHEYLLQHSDGSNTVCSISRINNAMLPSADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBL8</accession>
    <name>A0A2T4CBL8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_64200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBL8"/>
    <dbReference type="STRING" id="983965.A0A2T4CBL8"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="394" mass="43471" checksum="E4E7F467B773D766" modified="2018-07-18" version="1">MASSSTGGAPAMTASSPPVVVCVGMAGSGKTTFMQRINAHLHSKGTPPYVINLDPAVLNVPFESNIDIRDSVNYEEVMKQYNLGPNGGILTSLNLFATKVDQVVNLLEKRAKPDPQNPNRKPIDRILVDTPGQIEAFVWSASGTILLESLASSFPTVIAYIIDTPRTASTSTFMSNMLYACSILYKTKLPMILVFNKTDVKDASFAKEWMTDFEAFQEALRRDENSDVFGGQEGFGSGGSGYMSSLLNSMSLVLEEFYSHLSMVAVSSRVGTGIDDFFEAVEEKRKEFLDDYLPELERRREEREERKKKSREQELEKMMQGMTVDVNNVAEKGPIKVGADDDDVDVPSDNDSDDEDDDETTAEGLQARYAAAVDNQDQGILGDASFAKYLHKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC58</accession>
    <name>A0A2T4CC58_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1419518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC58"/>
    <dbReference type="OrthoDB" id="4896879at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="248" mass="28402" checksum="1F91B747745D67C0" modified="2018-07-18" version="1">MMGCSFPLWALDDTTLWRLPVPFVGPVLRTFGGLLLLANVNALYEKMGIFGYQRALPIYALNLILIGSIFLAISVFCARRLPNYELDLTTGFAVGTVTVLWAVTFALNMGIVLAGFARCNAPRLCKHFPLDSGSYCHFFGNPKLAEKSGWDGKAWPTYYRISLALFLMVAFYQVLNWYIWFRRVLPVVRNQRRQAARQARNDPHREATRLELLRDEELLFRQRRQQQMLQDLPPPSPAAIATAHHQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC79</accession>
    <name>A0A2T4CC79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1161683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC79"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="194" mass="22007" checksum="D66424508B63A204" modified="2018-07-18" version="1">MTMPQQAGRCLVKKGRKEERGKRMLADDVKWSVTKRRMESRTEQERSSSRRRRRDRTRRRETRRGPGNRKGVLGRTGGPFTLAASHLTRLLVVAVWRSKQVQLPAARCDWGRCSLVHAFEVLWEVALQGRVCIKAWGTDQGPLMASPPAVIFSPLLSVLARTALPQRAWPHGCRILRVTGLTRTRYDGHNGATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCT0</accession>
    <name>A0A2T4CCT0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1327301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCT0"/>
    <dbReference type="STRING" id="983965.A0A2T4CCT0"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="519" mass="57384" checksum="3D16018ACC49EE16" modified="2018-07-18" version="1">MFRSRFSDAFPKSLAHFGPQELERDVVEPIPGDRVEHFLCAVLGLLLNRKQDVKPGHYGRALEDAVASHKNQWPRSWEDKNPLAGGATFASLNPTERLNLLRYLVLWAMSSSETLKGLINQSYKQNRHEDDINQPRAVQPWGSDGDKRRYFLVEGQDDTAFRVYRESNPAGTNRTWWSVAGSIDELKALAEKLETKDGGPKAKKLSHKILQAIPRFEAGEEVAFACQCKRKRREYRQMRKEQFKRPEPGFSLYEGRTRGKRMKYTYSDDEDVFSDSTGYRRSARNTGTTTPAETAPVTTSSGRTVRAPPRLNVTTGEDLPNDTQGETGEAAAENPTGRPRRAAAANAGANGSANTDDEESEAEFGDDEEDVEAQIPEESDDEDEFKDEAMDEDDLEVAPQTLVVKLSVTPPKLKGVLTPSEQAANRLPASKEEDMKDEPTGPPDTPTPKQQSFDTAATVPAPSEKASERPTTPQPTEKQAGDQSTVPSVAPATALAFRGSPEKQPAQLVPETVKIISQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCX8</accession>
    <name>A0A2T4CCX8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCX8"/>
    <dbReference type="OrthoDB" id="4581301at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="567" mass="63613" checksum="0A7160C1D8C5B334" modified="2018-07-18" version="1">MIPSRCAWTLRLTTPAHRSVARNQKRSRTFVRRLDRNNEVYYTIANKRPPKSPDALPVRDDFFEMPDLLLDLDAEESPFVRQADEADERRWERKWDVNPRRTQAQKQLEGLREQLAESRRKADEILSNPANVWRLSSHDVLSAALRCQPGTVNDADLTAAVSELSSPPETLASRQDPGFLETLCRENGIPLHALQDDQVLLEWMILRYKSLQRTIINRSEQPPSPLELTAALKDQKSITGVRRLVFQTLGSEGAAKTYFLNRKKPTQESTITDDHVPRALRNALFRVLDQHPDKAAAHLEILGFLGNLAARLSLDNIALPPALIGLALRLSASAGIVQAASDWLHRGFEIRTWERRAASSNDVEEALNAFTEHMSGQGSGGLYTTHDRQMLLQLLTGIDEHHSLSSESFRSLSLFHLDDQSPISTAQAYGLYARYITLLGHLGALRTLWKEWHASRPIVTPFLNPRHASERLVSLYEGSLRIALRVAASQPETSCPPDMELGECVALDYHSIGLQDAGSGIVDEGATTELDAFTNESPLDLPSFDLPLDEWMMKVEGFILQRPPPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD44</accession>
    <name>A0A2T4CD44_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_47818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD44"/>
    <dbReference type="STRING" id="983965.A0A2T4CD44"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="555" mass="61104" checksum="31474F61501697B8" modified="2018-07-18" version="1">MSTIASGAQSPRLSATISLGQPVYDNESSKSADDDQPPAKRRKVYQPKERTTEYLNYLNKEDKDMTEAERAQEKRLVSALRKKKKIVVIAGAGISVSAGIPDFRSSSGLFARAKNQHKLKGSGKHLFDASVYRHDSSTQHFHAMVREMDELSRKAAPTHFHRLLASLAQEGRLMRLYSQNIDGLDANMKPLATEIPLPLKAPWPATIQLHGGLQKMVCSKCGHLAPFNSELFDGPEAPLCEACTVDDQVRTRHAGKRSHGIGRLRPRFVLYNEYNPDEEAIGNVSSADLKARPDCVIVVGTTLKVPGTRRLVKEMCQVARGRRDGLTIWINTDAEPKDALFKDCWDLVVRSPCDKVAQLAALPEWDCDIGNDFLVSAEQDSQNQERLKNTKLEVALPSSSPDVHNDLGQEAIPTPRPSPKLSAKKQIKLTLGREPPHNDKPTKAAAKPRARKTKQPAKPKAPPKNAVTELFKTGKSFSQANKDGKTLRTPLPSAPNRKAIKVEPQSFSSATPLSDSNASSSFSSAATTQPNNHKRPRETISPKSVPKGMRELLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD90</accession>
    <name>A0A2T4CD90_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD90"/>
    <dbReference type="OrthoDB" id="5121433at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="74" mass="8634" checksum="D48ABEF4FBDEAB23" modified="2018-07-18" version="1">MAESSSPTASTSKPKRPREDGEAIKSRLLDQQFHIGRYADPLVPRKTSDLQFWPKDVTPEMEKKWLAIVKEHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDA1</accession>
    <name>A0A2T4CDA1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Double-strand-break repair protein rad21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1327519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDA1"/>
    <dbReference type="STRING" id="983965.A0A2T4CDA1"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="525"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="66676" checksum="95355E10FE947C42" modified="2018-07-18" version="1">MFYSETLLQKTGPLARVWLSANLERKLSKNHILQSNVTDSVEAIITPNQAPMALRLSGQLLLGVVRIYQRKTRYLLDDCNEAMMKIKMAFRSSGNNDLAANLQVTNREALLLPDRITPYDNLELPPPPDASWLLSQVEDASSTQVGRKGRVSNTRDINLQEDFDNSQYLQSGMTMDEDALAPMDDLELELDFGIDMDGGPSIEMGRDAPAARSIEDDEGAGPDDTTMAMDGGVRIADDEGDIQMGDDDFQFNPDDQSAVPGLAALDINRERISESPLSDIDDQFAKEIEEEYSRHAHTDLYEPQEDAEDSPVKRPAQRPRKQRLMMPDDEIVLSSTHIKQQQAHRDNITKPTAFLPRDPLLLALVEMQKNGGFVSSVMMDGRSQGWAPELRGMLSLDMVRGANELKRKRDSGVADVESEAGGVKSPRLELGDDTDFTIDGNAFGNGSVAADGTIVEIPADESAAHFDDGEGSTLMPAFEDTTMPLVHPADSGPVSVGTRHAVHILRELFGSEAAVDADKRKKSAVVFQNLLPEKETTKAEATKMFFECLVLATKDAIKVEQGSGLGDPIKIRGKRGLWGAWAEREAGGEISNQDEPESAAPPTAAAVSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEK4</accession>
    <name>A0A2T4CEK4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1388388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEK4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="195" mass="22000" checksum="AA0A77B5B4F1BF6E" modified="2018-07-18" version="1">MEWADERKPRDEIPFDFMLLLVPTSQSSSSSSSSSSSSSTTDGLPLSASSSRAPFLPDSAAGGCWSMHKGWRFRCTRTNRLERVARCQLGMHPDGWGQQANEQPKGRDSRREGPEHRESCKGGRRLVDQAAAGEDGEERTKQESRGRDERGWRGLEMESHKHMSEKLISYFIARIRCIRFLANVTSRCEKPHSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFS3</accession>
    <name>A0A2T4CFS3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFS3"/>
    <dbReference type="STRING" id="983965.A0A2T4CFS3"/>
    <dbReference type="OrthoDB" id="5278911at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="51923" checksum="6E4EA5BE960274BC" modified="2018-07-18" version="1">MPKKRQHLKPFKPASTASPTPGSSSNAAGKAPRSVNELLASLRHASLDPSAPRQLPPVTPSVPPALREILQIPDTPVPAPRRQHRQRLDSNGRRLPAGPPPPRSWVASRSGATHPEGRLSRSTVNRRGLVDSALPGTYLPASRSFIDIILRRIAVDWDIHRVYHQHYLFYIPAHLKSALVRWVGIASPGGLSVEDLRLILLPSPDDLEDAEGDDSFEHHPEHQVAVNPEVNYLDLSGALGRSLTLKEVSDLLFPSRKQEDANEPQESWDENENIPSPPRALLPNLTHLSLALDPQLASEASWRQLLALSPKLTTVTHLSLAYWPDPTLTPRARRSTVATPQGQNIAYGGTSYYSHSIDHDWSEALLVLKMLSRNLYALEFLDLTGCAPWFKALMLQSDHDYVDWVGAWGKVTLLRILTGWTPGEDALPSELMAYREAIDVAASVEKYIRVMRAGKGRIITVERNRLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGL6</accession>
    <name>A0A2T4CGL6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1133558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGL6"/>
    <dbReference type="STRING" id="983965.A0A2T4CGL6"/>
    <dbReference type="OrthoDB" id="5154086at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="19723" checksum="1D602F4AA91BD13D" modified="2018-07-18" version="1">MNDHERWPNQQENELDRRNSIAPQIKPSVSAGEYSRDLARFARHGGPDLVRLRGYPERSGLATMASRYSASSATRRTRSTKGTTLTKRISAKSNNFEQHLNDHGIYTEEGWSDPRDIDEIRDRLARRRPSLSPSRFSNGQFAVFRKANREVVSEHDVMTKVIPTICGNTDIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH89</accession>
    <name>A0A2T4CH89_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1002772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH89"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="33813" checksum="8794A178D23BE794" modified="2018-07-18" version="1">MFLDKRRHRGVGRGFVFFLALLKPHTLFFFLLPDNLTSVARLTALEPLSTNSAWGQALLIVHTDQHLISLSHLPLCKNTGGRHFDVSGWQRIIAASCRHCPSCLSQSLLWTTVCPDTACYLAPSISLTGTSLSLSLFSLSILLSLCHSLQSSDRNSGCCLMQALSRLRSLFDPAEESKKHEVNNNNNTNAVAGLGCMRVPHHPQTPAQSCSFDRPASCTSWTARAATANCICSADNSRSLLTYLPPHRASELTRPGQARMPGCQDAKMLVRSSGAAVCRSASFPCPLRQLTSFAHVLLLLACLLAYLCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHF3</accession>
    <name>A0A2T4CHF3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1417739</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="13"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHF3"/>
    <dbReference type="STRING" id="983965.A0A2T4CHF3"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015653937" description="beta-glucosidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="704"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB80980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="781" mass="84703" checksum="714E674D33A3E9F1" modified="2018-07-18" version="1">MVAFKQIALFAGLARWADAADKVITNDTHFYGQSPPVYPSPEMTGGNEWEAAYQKAKAFVSKLTLEEKVNLTAGVPPNSTCSGVIPPIERLEFPGMCLSDAGNGLRNTDFVSGFPGGIHVGASWSKDLAFRRAAAMGAEFRKKGVNVLLGPVVGPAGRTVRGGRNWEGFSVDPWLAGVLVSETVSGIQGQGVITSTKHYILNEQETHRMPDANVSAVSSNIDDKTMHEYYLWPFQDAVRAGSGNIMCSYQRINNSYGCSNSKTLNGLLKTELGFQGFVVSDWGAQHAGVASAEAGMDMAMPGPAEFWGEHLVEAVKNGSLPESRVTDMATRIIATWYQFDQDDGIPKPGIGMPSNVLDPHEIVDARDPAAAPVLLNGAIEGHVLVKNTKSTLPLKKPRKLSLFGYSATTPDFFSPSKDAELSDSWIFGKEAFNPNYLSPDGFATFGRNGTTFGGCGSGAITPALAISPFEALKWRAAQDGTATFNNFLSDKPDVDPTSDACIVFGNAYACEGNDRPAIRDDYTDDLIKAVADQCNKTIVVLHNAGIRLVDGFVDHPNITAIIFAHLPGQESGPALTSLLYGETSPSGRLPYTVAKNDTDYGNVLDPAQATGEYAYFPQADFKEGVYLDYRYFDKEDIEPRYEFGFGLSYTNFAYSNLSIDHVPGANTYPWPGGPIVSGGQTDLWDAIATISVDVQNTGSVASYEVAQLYIGIPGAPAKQLRGFEKPFLRPNESQSVTFHLTRRDLSVWSVQRQKWQLQHGTYKIYVGSSSRRLHLNGTLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHR2</accession>
    <name>A0A2T4CHR2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1396261</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHR2"/>
    <dbReference type="STRING" id="983965.A0A2T4CHR2"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="37"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="341"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="501"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB81099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="557" mass="62523" checksum="A71CAE71886B0553" modified="2018-07-18" version="1">MTATAPAPEAAAASPPAKTKLHGRAFYESIGSPKYIVAPMVDQSEFAWRILTRSFLLPEEQSKLVAYTPMLHARLFSQDEKYRRAHFQAVRPGSDEPWLDGNPKIDRPLFVQFCANDPEALLAAAKHVVPYCDAVDLNLGCPQGIARKGHYGAFLQEDQDLIFRLVNILHRELPIPVTAKIRVLETKEKTLEYAQNVLRAGASILTVHGRRREQKGHLTGVADWDMIRFLRDNLPPETVLFANGNILQPGDLQRCLDATGADGIMSAEGNLSDPGIFGNPPPIEENSREYWRGKDGKGGWRVDAITRRYLDILHKYVFDEEPPQRRPLFVPGDDTAWLTQSETHDDADEPAKKKRKTDTTTSESDTTTTTTKKKLTPEQQQSPNLSAMQPHLFHVLRHFVTQHTDIRDMLARARRDGMAGYERVLDAVERRVAEGLLEYERTDGRSFDEELERTIAERTIDGVPEEESSVGTLKRCKRPWWVAQPIIRPLPSEALAKGAISLKKEKGKAKEKGDDKKKDDSKAKSENGVAVVDGKKETEAQQQTKQEIASRDELVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIY9</accession>
    <name>A0A2T4CIY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIY9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="166" mass="18044" checksum="8DACE3AFD28580B6" modified="2018-07-18" version="1">MTRSCDECENISTIGKARGDISMLAGDAHFGIQTWTTMGAACRWIGACGDGLFTAHRPSGLLGVVCTWISFVFRSRVDLLAALGGCLWRRKLHHHPQPVRLGIWTSFARDGDLAWILFDLHPSLLDREVVRLGGTCGCGVFVPASYSTSCWSYACLSSHGVVISNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ01</accession>
    <name>A0A2T4CJ01_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1466987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ01"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ01"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="294" mass="33831" checksum="9B856282AB6A6199" modified="2018-07-18" version="1">MGSQVDEELTVLVTGFQPFRSEYPINPSWEIAKGLPEYLPPRRAKDPDARHAVDIPPVRILVHPEPLRVSYKVVRETVPTIWQETYQDRKIDIVIHIGMAGPRLMYQIESRGHRTGYKARDVDGRHLDELEGKRNEEWVWHDLPDELRTDLDIDDIWERWLQHTPGNLDLRISDDAGRYLCDFIYYSSLASCYKQGKERKVIFLHVPADGSEAVIKQGQEVAVNLIRSIVESEVYEETMCRSAVCSTCKKQTWWGCGKHIPSVLDSVPEDSWCTCEPKVERDGKAYPPMATQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ10</accession>
    <name>A0A2T4CJ10_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1017055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ10"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ10"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001913">
        <property type="entry name" value="ABC transporter E family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="247"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB81502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="510" mass="57347" checksum="498B0892C6C7B3D9" modified="2018-07-18" version="1">MPRPGQVLGLVGTNGIGKSTALKILSGKLKPNLGRHDNPPDWEDVIKYFRGSELQNYFTKLLEDDLKAVVKPQYVDQIPKAVRGPEKSVKKLLESRHTLGNMDQVTSVLELDHIMDRDITLLSGGELQRFAIGTVCVQKADVYMFDEPSSYLDVKQRLSAAKMIRSLLRDDDYVIVVEHDLSVLDYLSDYVCVLYGQPAIYGVVTLPHSVREGINIFLDGHIPTENLRFRDESLTFRLAEAADDIAIDRSRAFQYPSMEKTLGNFRLRIDAGEFTDSEIIVMMGENGTGKTTFCRLLAGALKPDGKGSVPDMKISMKPQTITPKFEGTVRQLFFKKIKAAFLSPQFQTDVVKPLKLDDFIDQEVKNLSGGELQRVAIVLALGMPADIYLIDEPSAYLDSEQRIIASRVIKRFIMHSKKTAFVVEHDFIMATYLADRVIVFDGKPGIDAHANRPESLLTGCNTFLKNLDVTFRRDPTNYRPRINKAGSQLDQEQKLSGNFFFLEEKPEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ98</accession>
    <name>A0A2T4CJ98_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ98"/>
    <dbReference type="OrthoDB" id="4143643at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="167" mass="18095" checksum="A6FA5492D340420E" modified="2018-07-18" version="1">MSLPTLNHVFTMSITPKPPLNTGQTPRGKANWFEITSGKITSPDGQPIADVLSGGGDYLTRYVEDNVAEVDMRLIAQDSAGDLMRFTVSGFDYLDRATMLALDGRAGGEEGGGLGVAEPFGFEVLKCTTASERYRWLNFAMLLARVKFVVGDAGIESVVYTVYEVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJA1</accession>
    <name>A0A2T4CJA1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJA1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="54" mass="5940" checksum="6F4D1D14FACEED0F" modified="2018-07-18" version="1">MNPYIASCPVRLTRAHLIVSEPYPFGGEGSLWLTRMLVSQSLIGQTEALYSVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK23</accession>
    <name>A0A2T4CK23_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1397063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK23"/>
    <dbReference type="STRING" id="983965.A0A2T4CK23"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="577"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128125" checksum="FB15EB8027516C81" modified="2018-07-18" version="1">MGPVLVATMVQGENGETSKKLHPFFTKADIDQPAVPPPPLPIDTAPPASDEAPPATAEGPKRKRRKTDTPLAQDDAEGKKARRGRKSAKQTLNGAILSHLNKPEQSDEVARGIGSGQLASSLPEPTLVEASTQQPGDAAQQTSSNIETPQPFTATPRAQTPASVQSKKVLKFNPKTGTLGSPPKPKAISKPSRVVTIKYGRDDEHRKSVGNKIEGILEGKLQLPPVPSKRKITQPKQVQAEVVPEKAKSTHPFFMGKARPQPDASTQNDSAKKPSSHKTSVFMSTPVSPRKPRTNPFPSGKGIHFGIKSGGTKVPGAAHPLWPAHGMAHVRGDDVSNMRAVVQESGIRQRRSKRAAVAVAPQESVLRHLERDLDVPGIRQSLPRNYNSFLPAPSELRVPQRHFESGRKLQSRIRPQLQSHLANYPAYYNEDVDELANQQSPKLHPAINRLYKALETQLSAFDKSQCEGSSWVQKYAPVTAAQVLQPGKEALLLSDWLQALRVQSVESGSSEGDKEKGQPKKKRKKNKLDGFVIDSEEEDAEMDEISDSDGDLASLPGSKLIKRSVMRSLNTSKGSRLTNAIILSGPHGSGKTAAVYAVAKELEFEIFEINAGSRRSGKDILEKVGDMTRNHLVQHGRGAESTAIDPEEVANEINSGKQGMMTSFFQPKPKSKPAKPQRAKQSQEKENVEKEAKAPPKSQKQSLILLEEVDVLFEEDKQFWATLTTLIAQSKRPFIMTCNDESLLPIQSLNLHGIFRFSPAPLSTAVDLCLLIAANEGHALERSAVEALYKSRDQDLRATITELSYWCQIGVGDRKGGFDWFYLRWPKGSDLDESGDVVRVISQGTYQRGMGWFNRDSILAKSGLDAEQEAIEQVWDFWSLDMGDWCTSTDMTSWATRTATSLRTLEAYDDFCGAMSSADLCSGGAYGVQLQEVMDPTIPELATHAREDFILGQALLDADAMVHHAAPSKAISTCIKSLARATLLNLTAETSNAVGYPAHASLRPIDEGQAISILDSFFQTSPRQVTRMDLAIAFDPIAVPPKVAPTTYLDPSVFDRNMELIVLDVAPWVRGIVAYEYQLMQRRLKLSNLMSEGGKRKRMRTTRSAYSALEGGERRTTRRERHFGDCLSTQHVLRTGGDRWTDLVTEEMAKSETGDESTAASSPVSDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPT1</accession>
    <name>A0A2T4BPT1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1395790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPT1"/>
    <dbReference type="STRING" id="983965.A0A2T4BPT1"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="212" mass="24821" checksum="53C5161A381A445A" modified="2018-07-18" version="1">MSLLRTQAFCIASRVARQIQPRYLSTTPYLKTRISDAIVKDHRELEDYYNRITQSRDLDEQTRYQNQFVWELARHSISEELVVYPVLEKSIINGQQIAQKDREEHQKVKEKLYIFQKLSANDPEFIPTLKSLYADLKQHIREEEEEDLPKLEQAVSGDESRQLSKSFQRTKMFVPTHSHPSAPDKPPFETVVGLLSAPLDKLMDAFKKFPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPU3</accession>
    <name>A0A2T4BPU3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1365916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPU3"/>
    <dbReference type="STRING" id="983965.A0A2T4BPU3"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="186" mass="19986" checksum="31CF25CD9C2F41B5" modified="2018-07-18" version="1">MFSRGLRVISRRAIAAPLARPSLATRQLAPVASVQAQRSYHEKVLDHYSRPRNVGSMNKSDADVGTGLVGAPACGDVMKLQIRVDPETQKISEVKFKTFGCGSAIASSSYLTELVRGMSLDDAGKVKNTEIAKELCLPPVKLHCSMLAEDAIKSAISDYYTKNPSRKPTDLSGTSMKMPTTDAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQQ8</accession>
    <name>A0A2T4BQQ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1406397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQQ8"/>
    <dbReference type="OrthoDB" id="10472323at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="9058" checksum="3C97540769468580" modified="2018-07-18" version="1">MPVVAAPSSLRLLLRCPLPCPFVLRLLQFSPLLPCPLVVFLLLAFPSPPRPPLPETSTLAIVPHPPLTLPHSRSTKLPPPFVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQV8</accession>
    <name>A0A2T4BQV8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1139692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679146">
        <property type="protein sequence ID" value="PTB71701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQV8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="226" mass="25424" checksum="19113E462248ECF4" modified="2018-07-18" version="1">MSLWTLGRVGLSWFLGFFVFSFLVSPCFWLFSFVACCLVRFLAFVSLSFCQGSQPVLLLPLRLSSLYCSFLVDHDFGVLGELFSISFVLVHLQHFYRLIITFVGFIECSFCSFCFSVPVLFFAPVLAFVLSCLLLPSCLLILSYFLPLSCFLPCLGLCLALFFCSVSCVLLLCRSLPTVLCFPFLSLVRLSSFSVSPFSPWVWGLRVVLWLLEGVQCALFDPFPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRL4</accession>
    <name>A0A2T4BRL4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1426064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRL4"/>
    <dbReference type="STRING" id="983965.A0A2T4BRL4"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB71947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="12632" checksum="700E958EDE5EA2ED" modified="2018-07-18" version="1">MLLFCPHCANILTVSLTLNRTNRLECRTCPYEHAITDPVFSRRVFERKEREDVFGGPGAWDNAQKSKAQCPNEGCPGEEAAFFQVQIRSADEPMTSFFKCMTCGHRWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRY4</accession>
    <name>A0A2T4BRY4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1098376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRY4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="219" mass="23343" checksum="888D9C23340A6343" modified="2018-07-18" version="1">MACTGGCSSIASFSACHRVPEAWTSFQPPRATARESHPSDPRPILSPTAKGMMSGLLGKAGHSPKSGGLEQTILQGQRLGHAVRSQGYRTSQTESRYAALPTMLYGIWGMLLRSLPTLLLREASSPVTLHCQSQRRVHLQSCLTTAGQLTSCSLTRKPANGHDVDPAQPLTTNCVSNLLGEAARTEMALRNSKRGAWSLAYLSSSLTPSSVSHVCLDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS08</accession>
    <name>A0A2T4BS08_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_167119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS08"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="87" mass="9865" checksum="54BD23E4C034AD7B" modified="2018-07-18" version="1">MYSLLYSYTDADTGPILSLKIQPLQWFVLFSFFSLFFSSLKFHRSMPYMCKSTGRLTATPLAHDPQIPGFGWPGQGGHESIDENADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS17</accession>
    <name>A0A2T4BS17_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1425939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS17"/>
    <dbReference type="STRING" id="983965.A0A2T4BS17"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="74"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="406" mass="45285" checksum="B7B6E57F6C24A6E4" modified="2018-07-18" version="1">MKSLQLLRRRAISHLRTSSLSPLSRHPSPSASSTSRFSTDAASHPSNRVQIHLSRSIDPLLNLSVEHRLLQITPPDSTILTLYVNAPSIVFGRNQNPWLQVNLDRLAQIAQSPSAAGWNDAAIKLVRRRSGGGAVFHDAGNVNFSVICPPERFDRNKHAEMVVRALKALSRPNTRVNERHDIVMDVGSETEKATYKVSGSAYKLTRLRSLHHGTCLLRSPNLSSISGLLRSPAQGYLDARGVDSVRSPVRNVDVDNGEFKDAVVREFESMYGEVHLRDEFDDSALQAEEVRKGYEELRSKSWTWGQTPRFTFSTHPTQEDPRPRAELPFDLHMRLVANHGVIEDMDIKHSDGAAVDGLDASVFHGARIWEMDDWSASLARAGLGSSLSEEAGHWLNHMFGTEYTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSN7</accession>
    <name>A0A2T4BSN7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1394984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSN7"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="221" mass="24842" checksum="382C5FCECA130EE1" modified="2018-07-18" version="1">MTQFRIDVVSDIVCPWCYVGRRQVQRAQQIWLQRHPSDTFSVRYAPFQLNPDSPRGPGHSVDKQGYYVQRFGAERTAMIQERLRAVGEPLGIRFQFGGRVGNSRDGHRLIHLGGKHGEETQLKVVDGLFAAYFENEKDITEYDVLRDVAKGAGIPEEEFNKAIVESDEGGEEVDAAAGTARFRGISGVPDYTIQGKYRLSGAQDAMEFVKVFERIKAEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSY6</accession>
    <name>A0A2T4BSY6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_156434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSY6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="141" mass="15667" checksum="405905F6BAB7C306" modified="2018-07-18" version="1">MSFPTYRQAIIYSSARTTTTAIIPEHISSFKRSPIRSKTIHTRTRLSAGQVTLTHARLIHGSPKRLATKQHPSTALPKPSRHPAFLHSTFTHHSSALPSSLTSFPKSGNIIIHQTHPTRNLFPRRLNGPSLHRPSHAIAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT98</accession>
    <name>A0A2T4BT98_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1341867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT98"/>
    <dbReference type="STRING" id="983965.A0A2T4BT98"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="2">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="121" mass="13680" checksum="6B8EA5425D314206" modified="2018-07-18" version="1">MGAILLSLLTSGIWLYTAFNEFLLLVGVVAPLDMQQLITYVCLTHSDAIEGIDTVRVYHSGPRLIAEVDIVMDPARTLMETHDVAEELQIKLESLPDVERAYVHIDYETTHKPEHAYKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTB4</accession>
    <name>A0A2T4BTB4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1472844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTB4"/>
    <dbReference type="STRING" id="983965.A0A2T4BTB4"/>
    <dbReference type="OrthoDB" id="5366531at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="83592" checksum="84C90F21D68F93DC" modified="2018-07-18" version="1">MTQQLARAHKLLKESAAKQLAAVDLEGEEEDWYVPLNTEIQPYDAATWEAVCDILSKKHGSDGVWAVFEAIWHREKHDMIIFRDAESLRGKILSAALGSKSRLSTLFAAAQQLLAEDNFQWPGFYTRVLRFFLERGAYQDAIFWDRKLAPIFPTGADEFGALLAAFVIKPTPEMQSTLTTLYVSSANRQLYDHVIPALFASGQSKLARTWRKKLIVFKDFPLTSNCRPFLLFLASYYPEIPLTDSELAVADLDRQELADVDDEESSFEVVRKSVDKRGSHSDALVARWLASTWASVEFAINLIYKLGVRTIGPRSLQALALRDPDAKEVASRIDQIERLGMRISSHSYCKILVSFARNGSEELLQDLIHCDIHPDEFEDMDTRHSLMAEAARTGDWKLERLLQGIEWAIETGPTSRRLNSLLRNEVSNGSLRKARQVLDRMEALKISMAQASATGLLRRAFWKLDIHPAPRLRPLHPNYTHNEIDKRLLDRALNVIRRVSCHDVAIPTRYWTMLLNNLGRSGRLDDLEQLSLKIMQLYTPPYGGLVPVHREDLPKHFNTEEKEYIPADLPFTHHHHPVRLIFDTSLQRSIVRWGFDQTLATKPQPPTSLTRPRTAGFSQFDVARGVRLLAALRDQGALVDTQVVRSSIMLRIATSMVPGRPRHRSRDSVEFSVEHLLRLAEEAWGSEMFPDVPAAVGEVDKRVSKLWTRYPRLIDSTLDKTVTQGGGQSRQRITPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTG1</accession>
    <name>A0A2T4BTG1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1341481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTG1"/>
    <dbReference type="STRING" id="983965.A0A2T4BTG1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF188">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="521" mass="56842" checksum="F8FA2BE1CACCA45C" modified="2018-07-18" version="1">MQDLVSNGHPDLEKSCPPWPRPGAAASAQDADSEKQGGSPNRRILVTCAPEDTLNPQNWSLGARCKNIAILAFLIFVQGWAGASESMANSVASSHLHVSQVLENLDIAMYLFGVGIGSQVAGPLSETVGRNPVYLIATFCYLFFVLGSAKAATFGGRITCRLFVGLFSSATLSINGSSVRDQFRDVKRAFVFPIIAWVNVIGPVVAPIASGWLVANPSLGWRWPDWLTLMISGAAFLVALLFLPETYLPLLLEWKAKELRRLTGDQRYYSEHAASSSLPSRLKHNLKLGVTFFSTEVIVTVLGLYLLLLYTLLFTSLSGFDYIFKETYGLSTGLTGSCFASIAVGSTIFTVSAPSWYLWARRATAHVHGASVKPEFRLWPAIITSPMLPVCLFWLGWTNYPTISIWSGLAACCVFGIVLTAFYVSSYEYIIDSYGDHSAIALASITSLRYLAAGGMVMATRPMYSAIGVHWTMTLLGCVATILSPAPILFWFYGPRLRRHSKFAKDPEQDSGKSGRDSGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTU7</accession>
    <name>A0A2T4BTU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_150608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTU7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="170" mass="19059" checksum="75DAA6A870522E63" modified="2018-07-18" version="1">MAWLVPVYPTCSLPPSLPSYWSVMPVQPSIPLLDRQASLNVVLGRFPSFSLSPNLPQSSRPPPRFSDTLLSRQRPPSPFRHSRTSRPSSCSLLPPPPPPPLPSLSSRARSKKETASRKIKVRRNVRLHVLPVHASSHARLAQAFHPRFRPPGGCVAPQRTTSRRYEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUR3</accession>
    <name>A0A2T4BUR3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1340145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUR3"/>
    <dbReference type="STRING" id="983965.A0A2T4BUR3"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="78"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="488" mass="53671" checksum="DBA85490BDDF6C8B" modified="2018-07-18" version="1">MSPQRKLLLLGTFVHSQTPQTLDIFHSAGIAVDAEGKIAAIERDASDSSEAKARLLERLGWDEAEVDVTQAADGQFFFPGFIDTHIHAAQYANAGIFGKSSLLDWLETYTFPLEASLSDLSKARRVYARCIRRTLSHGTTTAAYFATIDVAATNLLADLCLSMGQRAFVGRVCMDRAEIVNPTYYRDASTEASLEATQQTIEHVRRIDPGFDLVSPILTPRFAPSCTREVMAGLAQIHRETGLPIQTHLSENAGEIKLVSQLFPEASSYTDVYHRAGLLTPRTVLAHAVHLSEEEADVLASKGAKVSHCPCSNTSLTSGAARVRWLWDKGIDVGLGTDVSGGYSHSILEAARQAAMVSRHVAMNVDISHEDAAVAEEMTAREKERVKLTVEEVLYLATRGGAKCVGLEDKVGGFEIGMEWDAQLVALSHVRDGGELHLHDDAEGEDDHGFVDVFGWESWDDRVAKWLYNGDDRNTKRVWVKGRLVHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUZ2</accession>
    <name>A0A2T4BUZ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1404851</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUZ2"/>
    <dbReference type="STRING" id="983965.A0A2T4BUZ2"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="202"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="505"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB73122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="549" mass="60965" checksum="C0DEEC3440482102" modified="2018-07-18" version="1">MSSIYNLEPQPTGSVILHTTMGELHVELFAKQTPLTCRNFLQHCLDGYYDGTIFHRLVPNFIVQGGDPTGTGNGGESIYDGGAFSGDLDPWPMDQRRGQNAGPNGINFKDEFHSRLRINRRGILAMANEGRPDSNGSQFFFTLDKAEELNGKNTMFGRVAGDTIYNLAKIGESEVDEATERPLYPIKIERVEILVNPFEDMKKRSRVAQTQVKPKVEKEKKKKRKGGKQLLSFGDEEGEEEEPVFKKPKFDTRLVMEAEEEATAPNPSKAKASRSKDAEKKASDTLSTNDKGKEPASDTMDDARQGEEAQKEKSVHKKRKEPSPELSPEPEPAKQKSALERANEELAALKASMRRTIHSEEPVKEKKKTALEALIPETSIRGRKRRPGANNASTSEEQASIQMLKAFQAKLEKAPPSKEVTIEAPANNGSGDAEKPAQEDEAELCDLHFIANCQSCTSWDQQEKEESDDEGWMSHALSFAADKLGKDLSNRRKAEEELVVIDPREKSRTLKEEKRAEREARAGGSGRAWDQARNAQMARAASLAGRGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV05</accession>
    <name>A0A2T4BV05_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1425103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV05"/>
    <dbReference type="STRING" id="983965.A0A2T4BV05"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="134"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="351" mass="39436" checksum="AB313EA96B5ED7CF" modified="2018-07-18" version="1">MPVPKRETIHPDADSLTKRHLGAPRKETTDLVGKEVLLYRCQTGKDAEEIIAMDLPFVIFIPFGRGGEEINRRIPPASLQLPSRIAETYYELVVTVQQGPKNQFKYNFPLPILRYDTLSTFGMYNKPEAKLVSSDNVVNLGINLPRWSYGPSDPITVYIKVSPAQGAWYKARKVTIDKITLGIEEEITFNPEGDEPTKRVNKLAKQVQVVKTKLPEAGYATNIGLIFPSKDLRDSEGIIKRGKPAFPQYEVASFTTTSTLYKIEFYLNIKVQVSGARDLQIRQPIVICHLDQQGCKEEMDAIEIAAREASHVDPNNPMLPASTIVTANDRDALRALGLCVVRHTEKRPYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV89</accession>
    <name>A0A2T4BV89_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1362447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV89"/>
    <dbReference type="STRING" id="983965.A0A2T4BV89"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015668284" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="229" mass="24743" checksum="784B6D7E6CD9F313" modified="2018-07-18" version="1" fragment="single">MNLLLLPLTAALAALAAASSSQTHLSVALPPKPNPFLLPSSTHATLSSLHKRLSAPLSAVNTFDFHNVSADSYLLDVHCPTDNFLPLRVDVGPDGEVRAWETYRGNEWGNKGEEVPVRGEGAGTTTTRSLAVKAAGPKIFFMERTKFSVLSILKNPMILMGLVTMGIVFGMPYLMENMDPELRAEFEERQKESPMNAIMANAQGGQNPLGNFDMAAYLAGSGKKEGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVZ7</accession>
    <name>A0A2T4BVZ7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">N-terminal fungal transcription regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1339454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVZ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BVZ7"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="626"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="725" mass="81295" checksum="A250B400C60D70D7" modified="2018-07-18" version="1">MSPTSPASSRQGNGMPKRKRSAGMGLESSPGSINEDDHGDQHDHGEHDKKRQPGVKRACNECRQQKLRCNVVQEPFQSCSRCNRLKLECKIESNFKRIGKRSKHAEMEKEIDRLRRNIARAQAQGYILEDDETLNSPMAPSTATYSHTRNPSLMGSDEAVSSLLHLKRGGSYSMPRFSHELEGVQLTDEAVTHLFNEFFAFYHPFLPFLNPQQSPDQYHQQHPLLFWSIIAVAARRFSPTNCPNLISNLSGPLTRFLWTTIGEVPSNYYVVKAMCLLCAWPLPTSTTTSDPTHILCGVMMKTATGIGLHRPNHIQDFSRTSVDLNKEQLADRVTTWAVCNIVAQNIGTGYGQPASSLYDWTLALRPGDDPALHLSPELEARLQIERFCDKVSKEMYSNASDPRGVAGDEHRAMLMRVYRREYSELYASIMSQQLGPVVNLHLRAAALHMRLAGFFDSSKTPGYLDDLMGLWRATVSFLDDLLEVDKVSSPHDNIGGTFLLYATNYIQQMLVAAAFTLLKLMRSFFSKTIDFQRGRNLFHRSIQAIRATSVVTNDLQWRLAELMVQMWNGARLDQKKYNHEDDSPIQVDDSLQLKVRCRHSMSLVFDSVWRWREEYQALGRGSLEAALKHPTNPDSANESSAASSQLDSTLMPSHSLPTSNNMLPANGVLTPGAPGLSAPATGTTSMIGNINYGGDTNYDFFDPQHWMLDGLLDFNYSFVPPLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW15</accession>
    <name>A0A2T4BW15_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1404508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW15"/>
    <dbReference type="STRING" id="983965.A0A2T4BW15"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039553">
        <property type="entry name" value="Prefoldin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13758">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="522"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="599" mass="66821" checksum="9408B14364D694E0" modified="2018-07-18" version="1">MSDARDSFSDLEKHRLRLEETVNSLRKALQHWQTWDAEYEALKEEVEAVTAADELHRIHADFDGELLKGKELDDVFGKPGLKTREQIINVLDRRIDYVSKNIGTLRKQLETAENKYAAATVISQPDAADEDGQPIMDIVEELDDDDNVISFRVNRPGETLGSVEALLNKAGVTDDAEPQPEKEKKASNSVIDHQEPPSQLRNQDAPSVASPKPPSPKPEYEPKKTVSFSDDTKPAEEPEPEMSWRAKRVKEIMGTAKEQEDISMRAAVIPKDESPEDAALRQQMLRYGMSEVGAVVAELELEEGDSDEISDLDEELDDEYDDYDDEEDDEDQYGRYQGSVVTDEYRRRMLQLEKKLGIKSHAAKKAKTVTDEDGSEDDDNDEGIGRIVVNREAQASSSSTATNAAPLKSNLKERQSSDSEAKKGVRFAASLDIAPEKELSAPVVSEKKDLVEPLSDIVERSSSSRPSKQSAAQPAKRASRFKKAKDTTETASAVPKGPLDIRPKFVDDPLPPVPTGPEGVTIADKLVERESTTAAIAPDEVNDLMTHQEVADEYQRMRKKFIQREGGFLKPDESPIKPVRNELEEQPTSRFRAARLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWZ6</accession>
    <name>A0A2T4BWZ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_6852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWZ6"/>
    <dbReference type="STRING" id="983965.A0A2T4BWZ6"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase lid" evidence="1">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="15139" checksum="3344B9964F4B3411" modified="2018-07-18" version="1" fragment="single">TQTTDIFRLNIAKLKVMESERHKMTGEPALAIKDDEILEFATKHYEDLARSTGCWNGRQIRNAFQIASSLALHNYTKDADAARAKGQLPPAAPVLDRRLFDKVQMSTQSFDKHMKKEEGKYDDGLPLRATFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX37</accession>
    <name>A0A2T4BX37_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1338928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX37"/>
    <dbReference type="STRING" id="983965.A0A2T4BX37"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="141"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="587" mass="64350" checksum="D285B9FC04CFB286" modified="2018-07-18" version="1">MPDDEEQARGRSRSRSRSEVRDTAALSESSEDEIERDPSLDEEEKADDLDGHRPALREIRSHASRTSRDRSRPGSARGTGTGTALDQTLSRRDTVLSRLRSRPTIQFTHPLAHIQTTADEIVDFDGPDDPYHPLNWPTHKKVLTTALYGFVTMTATWASSSYSAGTIQVAQEFHVGTQVATLGTTLFLFGFGVGPLLWAPLSEVYGRRIAVMAPMLVAICFSFGSATAKDLQTLMLTRFFGAFFSSAPVTNTGGVLGDLYSPAYRGIAMAGYAMAVVGGPSLGPIVSAAVAEQASLGWRWTEYLTGILQAFVLVIAVVFIDESYPPKLLVYKARRLRHESGNWALHAKFEEWDVNVKDLCKKFLVRPVQLLLTPICFLVALYASFCYGILYMQLGGIPIIFREIRGWNPLVATLPFLCILLGAVFGCGANVYNQLLYNKAYYAAGNRAVPEKRLPPMMVGSLLFSGGQFLLGWTGPRRDIHWIVPCIGLVMLGTGFFTIFQAALNYLVDTFQTYAASAVAANTFLRSCFAGAFPLVVGPMFHNIGVGPGSSITGGFAALLIPVPFFFYRYGKRIRAGSKWSKGSVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX96</accession>
    <name>A0A2T4BX96_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M440DRAFT_1471953</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX96"/>
    <dbReference type="STRING" id="983965.A0A2T4BX96"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="631"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PTB73953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1182" mass="130402" checksum="DBA94FB379F939DB" modified="2018-07-18" version="1">MGLPDPTVDLHWSSYIGAIHEIFHKNALKHPDAPCVTETASSTTPERRFSYKQIYEASNTLANQLREAGIENGDVVMIFAYRSVELIIAFMGTLAAGATITVLDPAYPPARQQIYLEVSQPKALITIGRARDENGTFAPRVQKYIDEELSLKIRVPELRMSDDGHLTGGEVDGKEVFTNAETKASAPPDVLVGPDSTSILSFTSGTTSTPKGVLGRHYSLAKYYPWMARTFNWTSETKFACLSGISHDPIQRDIFTPIFMGGELIIPARENIAHEKLAEWFRDHKPNAVHLTPAMGQILVGGAKAEFPSLKWVLYVGDILTKKDCAALRRLAPNADICAAYGTTETSRSVSYYHIKNHAEDPNALDQFGDIVPAGRGIENVQLLVVNREDPTKLCGVGEVGEIYLRSAGLAEGYLNDPEKTKEKFIDNWFVDNQKWVEADNKVADLAKEPWRKYYKGPRDRIYRTGDLGYFLDDSGNCAITGRADDQVKVRGFRIELNEIDSNLRGHNLVRECKTLLRRDRNEEPTLVSYIVPEEQEWLKWLAEHGLEDTEEQGTEIGPVTVYSKRFRPMQAEIRDHLKSRLPVHAVPTYFIFLKKMPLNPNGKIDSPNLPFPDAALISEEASEEDLKIWESLSSTEKELAEQWATLVNGLNAKTLRPESDFFESGGHSLLAQQLLLNIRKNMGANVTISSLYSNSSLCALSTQIERQREGKDDSGAAEDGEAAYAQALDKLLGTLDAKYQTADPAALSPSGKTTVFVTGATGFLGSFIVKDLLERDNVHVIAHVRGTKGVAAALERLQNSLRGYSVWQDAWAPRLSAVIGDLAQPRLGLDDETWKTLSETVDVVIHNGALVHWVKQYKHLERSNVLSTIDALRLCNQGKPKLFSFVSSTSVLDTDYYIKLSQEQTSTGRGAVMEADDLSGSRTGLGTGYGQTKWVSEQLVREAGRRGLLGSVVRPGYILGDATTGVCNTDDFLIRMLKGCIQLSSRPHIINTVNAVPVGHVSTVVVAASLNPVPAETANSNGDVGVHVIHVTAHPRLRMNEYLSILSYYGYDVPEVDYDHWKAQLETFVSSGPIQKDEEQSALMPLFHMATNNLPATTRAPELDDRNAVAVLKADADRWTGVDESAGEGISRETVGRFLRYLAEIKFVPWPTSRGRELPAIKAGVVEAQARWGVGGRGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXJ8</accession>
    <name>A0A2T4BXJ8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED8</name>
        <name evidence="11" type="ORF">M440DRAFT_21540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXJ8"/>
    <dbReference type="STRING" id="983965.A0A2T4BXJ8"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB74060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="256" mass="28629" checksum="5B412DADC7B3F012" modified="2018-07-18" version="1">MAALGLDDDELKSVEQTLARLAQLSSSIQSLKMDILKSNPLPHPSSLQASAQILQRNLQTVLDNLSENSELFSRIAVHPSTNYPGRTQENVLTQLLRKKLEPDVEELVAQGRETARLVTPEGIAELQNIWDELRAWTQSRIATYVKEEAEDVYTKAEREMGIDKVRTGLRKGLDEESDEEDDEDEDEDDDNEDMDEANDGDPAKSTLVGRGPEPETLLWFAARGDFELPRNIEYENKHAVKRGFDGVNIPPGSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY02</accession>
    <name>A0A2T4BY02_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catalase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1041466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY02"/>
    <dbReference type="STRING" id="983965.A0A2T4BY02"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="6"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB74210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="492" mass="55192" checksum="9AE8ED3CD0A77E6A" modified="2018-07-18" version="1">MASFYTGAEGCPYPNPTTSVQLRNGSGGGLVLLQDTQLIETLAHFNRERIPERVVHAKGAGAYGEFECTHDCTDITSASFLSKVGKKSDVLLRISTVGPERGSADTARDVHGWGMKIYTDEGNQDFVCNNIPVFFVRDPIKFPSVNRSHKRHPQTNLNDSDMFWDFHLGNPEGIHALMHLFNDRGTPASLRNINAYSGHTYKFTKEDGSFKYIKLHIKSQTGVKNFTAEEATKTAGENPDFLTQDLFEAIERGDFPRWDVFVQVMDPKEAEAYRWNIFDMTKVWPHKDFPLRPIGRLTLNRNPQNYFTDIEQAAFSPSNMVPGIAPSADPMLQARMFAYPDAARYRLGVNYQHLPTNRSKAPVYAPFQRDGFMNFSANYGADPNYVNSSLKPTPIKNAGNVGSTITEHERWAGEVSSFTSEVGPEDYEQATALWRVLGGQEGHQERFVGNVAGHLAKARNATIRSRVYEYFARVDEQLGSRLREVTEAKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYR2</accession>
    <name>A0A2T4BYR2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1317693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYR2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYR2"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="19979" checksum="49631F2293E8468B" modified="2018-07-18" version="1" fragment="single">MAGGTVKYRHLSRNSSARQALLRGLVTQLVQYEHIQTTYAKAKETQRLAEKLITLAKRNNEPCRRSAQGILYTPNLLLPKLFGELRNRYLTREGGYTRVVRTEPKNTYDQGESAILEFVDGKKDSRFMMTAKTLARDRLLGRPSTPVTLQNVKKVTKFRDEKELEDMVQRFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYR8</accession>
    <name>A0A2T4BYR8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1047323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYR8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="195" mass="21482" checksum="47A838A8C420F501" modified="2018-07-18" version="1">MVCCGVIVVHSQETIGAYRMSVHHNPAGETCSPSTMLRRTQPMVRTGSRVMSQTSITTTAASIKTLQQYYAGILDVRHAGRSWGKALMSTLQGSISGAISHGTRRFESASAKAVCPCLVFLYDQSLRRRPSTSVTLHIRLSKQHKAPMGTAEILPIRSEKPWEMRVAIRAGFGGCVSYQFHLPHLYYILGLATFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ08</accession>
    <name>A0A2T4BZ08_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1028806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ08"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="86" mass="9025" checksum="87FE53BFF018DE9D" modified="2018-07-18" version="1">MLQLTGWRPHACDASVPFVCCALLPVRSSAAGFASDLRLYATLAAIYRNRQQGFCFAGWPLTAAGLGLARGRQKGRAGPSSSGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ87</accession>
    <name>A0A2T4BZ87_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhamnolipids biosynthesis 3-oxoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1440082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ87"/>
    <dbReference type="STRING" id="983965.A0A2T4BZ87"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="268" mass="28049" checksum="C12B7602A258CF57" modified="2018-07-18" version="1">MDIDNLFNVKGKVVLVTGGAKGIGRMIAEGFVANGAKVYLTGRDAAACSSAAAELTKLGSSTNSGGSAHALPANLQELSQCEALVKRLTELEPHGLHVLVNNAGATWGADVDSYPDHAWSKVLTLNLHRVFTLTQLCLPLLERAATREDPARLIHIGSIDGLRVPTVSNVAYAASKAGLHHMSRVLARELGPRHVTSNVLACGPFATKMMRATLEAAGEALMEEMPRGRIGTPQDVAGASLFLASRAGAFCNGAIIRLDGGASHVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZZ1</accession>
    <name>A0A2T4BZZ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 95 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1380523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZZ1"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF0">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="277"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="719"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="797" mass="88314" checksum="B97B9FD634AF214B" modified="2018-07-18" version="1">MSSEHRLFYTTPSTSFPTSLPLGNGRFAASVLSCPSKEVLILNEVSFWSGKPQPAGAGLSEKPKQAKDELRETQKCYLNGDYAQGKKRAERYFESKKTNFGTNLGVGRLEIAVNGQGAVENVSGFERELRLDEAVAETRYALDGRQFRRRCFLSHPHQVLVVQFEGDDLDGLEVEVGIQGENEAFTSKVNENGRLEFNAQALETVHSDGTCGVKGYGLIAATVYQGKVQHRDGKLVVSAKKSMTILVTFNTNYTEPGDDQWKKRTVSQMEAALKQSASDLFQAHLDDYQPLYRRVSISLGSQSESGSAATTPTDQRRSSFEASGYADAGMFALYFHYARYLTIAGTRQDSPLPLHLQGLWNDGEACKMGWSCDYHLDINTQMNYFAIMNSGLSDLMQPLITYLGHLAASGQETARVCYGCHGWVAHVFSNVWGFTDPGWEISYGLNVTGGLWLASHLIEIFEYSLDDDFARNEAWSVLSGAAKFFLEYMVEDPKTGWLVTGPSVSPENSFFVVNKNGEKEEHYAALAPTLDIVLVRDLFAFCEYVATQLGCEEYNRKEEIRTYQEALAKLPPFQIGKHGQLQEWLHDFEEAQPYHRHLSHTMALCRSAQISARHQPDLAEAVRVTLERRQDREDLEDIEFTAALFAHNYARLGDADKALAQVGHLVGELSFDNLLSYSKPGVAGAENNIFVIDGNFGGAAAIAEMLIRSIIPRLGGPVEVDLLPALPAAWAEGKVRGMRIRGGLEADFGWRDGKLDGVTLRASAASSLVLFYGEHRFVTRYQAGDVLKLGPTLELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C015</accession>
    <name>A0A2T4C015_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_6276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C015"/>
    <dbReference type="OrthoDB" id="3513679at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="390" mass="44637" checksum="DD91E65E4F9F3250" modified="2018-07-18" version="1">MASNETRKARLPRHEILHQLRGYQEGNHRDLVCNRSVDCRWIFQPSVSDMASLAAEMTLEDADDCCNKATGIYVHSATRIGYPCLLLQTLHNYLYGRWFRPYKSEIEYVQFIAKTFLPELLLEDLRPGPLANLAVSVHAAICNRAQEIRDAVKNLSPHHSRSDWDPPPANCPRTLGRGAYSRMELERIIRHQEFFVLRPLFRAIIIIIRLEEYNDKDMDIAQLPVLLVRTGIEDGLSAPISFEPIAHQIHSAIHDTANGETAVRVALEVAVDFIMMLEKRETDAFGHQPDPIASTRDLEDGGLDGRYGILQRAKKLGWGDEPLAGPSSEWVDTKIHTGWCGGGVDSDNWNRRAQRLEREKVIRAEEMYPEPYQWPVIMKGSRKYWKIWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0C2</accession>
    <name>A0A2T4C0C2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_335082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0C2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="17261" checksum="9CD9BD254CDA6EE8" modified="2018-07-18" version="1">MYSSRPEPSLTTATSSISAISPSRHDTKDALDTRERSRPFVSISGVVHDTVQYTLRSIPDAQVSLSNDWLLVGSINPLPSLAPGPSRARPPVFSANLSCQGLLAQACQTNAILYDELHAISPCQLPLPQSARDKATRDNLAAIRIPPPRPPDIDTHSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0D9</accession>
    <name>A0A2T4C0D9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1458413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0D9"/>
    <dbReference type="STRING" id="983965.A0A2T4C0D9"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF39">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="299" mass="33057" checksum="C2FF8A37DF71606E" modified="2018-07-18" version="1">MTRSMLHRLEDLCNVDVDDADTELIKSIPFTPHNPDEALLKDLVRQYGSQGWERVYDQAAVHLTARNIPHLSGRVLIQTSLRHVSSSAATLAHARRLAALYEEAGVPRDRFAIKIPFSGPAAAAAAVLNAEGIRTLATGVFSLEQGIAASQSGCLFISPYYNEIAAHLDPSLRLTLEDPALEHPMSPRVIHILEAFAKAYRETGKEQPIMPTKLNYGEFATVQRLTKLSTIDPFARPDWDGKLADMQTDYIANDGEKLDEALNRDPVAGKRLKDAELFFIEMENKAKEAIEKEIAAQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0L6</accession>
    <name>A0A2T4C0L6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1423187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0L6"/>
    <dbReference type="STRING" id="983965.A0A2T4C0L6"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="3">
        <location>
            <begin position="371"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="533" mass="60136" checksum="EA9A49800E2A25D0" modified="2018-07-18" version="1">MPPQLLHLPDGQTFTVTPVFAGVGFKSHEMTMHPNAFPIGWNVVLQTEEDVESRPDDANNKDDDEDDDDDDDSSSSSPSSLSRKKTRVHPFSRPTLQNDSLFISSISNPSNSDFKPAASPTRQIAMMLWVTLYWYFHQPEPDRKLRTAASRDTPDAAKPVGEWKINIKREGVLRGRNLIPKLERMGLIAAEDPSCGTALDDAGAEWARMFVSRRMFWQIPGHLFLFTLQPNHNRMNSSVPGSPVVSRPSSPVRGDGSRTPYISMDGFARLDSDLPGGPTPTSAPHAPMVPIGPFYSTSHLPTYFPPLTLQYTVTDGVRHPVRSKPPRMGEIFYSRFIPSVNQYLSFRVASTSTHPVPYLGPVGGKAPEHTHLAQLTDAQLLQRWMSKPRVSEFWGEYKPGFLEGVLRQRHSFPAIALWNGVPFGYVEIYWVKEDILGRHLANGAGDFDRGLHVFVGEEWARGRVPAWLSSLVQWCFLNDNRTMSVCLEPRVDNKRMLRHLDEAGFGKERQVSFPHKQAWLVRLWREAWEGPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0M6</accession>
    <name>A0A2T4C0M6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1402687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0M6"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015625086" evidence="8">
        <location>
            <begin position="38"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="518" mass="56578" checksum="7C122B823096986D" modified="2018-07-18" version="1">MLRRTPTGTWIPAWVPESTTTVSVLLLVCSMVQSATGGYDGSMLNGLNILPSYTDYFKLNNATTGLNTASVFIGGFFGPIWAGVMTDRLGRRPAIFWGSVVTLLGIVLQTAAQNVAMFVVARVILGWGSAISSVAGAVYLSETFASRYRAWGVGILNNFYYVGSLIAAGVTLGTGQWQSTWAWRLPSLLQGIFSLSCILVLPFIPESPRWLVSRERYEDARLSVAQTNSNGDVADPVVVAVYKEIIDTLDWEKKHDMTMSPLEIIKTPTARKRTLIGASVGPFSCIAGNVIASYYLGSELDTAGITDTNDQLKANVVLNVWCLFCAFAGTHLAAIWGRKPTALFSQSLLIVCLFIIGGLSKMYADDPDGASQSLIYGDVAVMFIFQGIYSIAWTPLLYLYPPEVMNYPIRANGLALSGFSLNGLALLLTFVMPIALKTIGWKTYIINGSWDIITLVLIAVFWVETKGRTLEEIDAIFEGEKHSSVPDVEDIRTGKKTLDVQQIEIELHEEIGLKTNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1V9</accession>
    <name>A0A2T4C1V9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1377951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1V9"/>
    <dbReference type="STRING" id="983965.A0A2T4C1V9"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015784789" evidence="4">
        <location>
            <begin position="28"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="45"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="514" mass="58008" checksum="5E6CDC1413E9FEA0" modified="2018-07-18" version="1">MAPTSGRVNPLLHPLLFLYQLLQWVIDRLLSPKPPKRVDELTRPKIGIIGAGLTGVSAAAHCVGHGFDVTIFEAGPRENLGGIWSRVNDTSGLQIHSIMYRFHPSVQWQGGYPNRKQIVSQVEQLWKRYGLDKKTRFGVKVKGVKQDDQTRWIVNNDPSLGRFDGLIVAVGTCGEPKMPHIQGMDRFKGEIYHSSELTGKDAKDKHIAIIGGGASAVEALEFAFSAGASKVSILSRSDKWIIPRNMLVDTLLSLNIFGQETLFSFIPEFLLRKFFYRDLEDLAPTHDKGLFESTPMVNSAVMDKLREGRAEWIRGDILGFTSRGVKVNRRSRGVPKGGPGHEEVVKADIVVMATGFKRPSLAILPDDCFEEPYGPPNWYLQTFPPAHPSVSAINATFVEAIGTVGNWHIGIYTRILLMFLVDPLTRPSRWWMERWIDMTRTLKRFSPTGAFDFFTYLELVWWFVFCVAFNPFRWKWALFVFFGVGIGLPDKVVRAEKQFVNGEGYKNRDEGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C260</accession>
    <name>A0A2T4C260_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_355973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C260"/>
    <dbReference type="STRING" id="983965.A0A2T4C260"/>
    <dbReference type="OrthoDB" id="3439209at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57773" checksum="C7C0CE81A850A798" modified="2018-07-18" version="1">MSHIPANNNMDSREHPDTNDADTQGYGTYAFPNGQAAENPSRTAGNDTTQGHGLIYDHEFDPNCLDCQRRTFELLNLQSHAPSGIASSVYSNPGQQFAEYPTMTMGDDTVFQSLSDFEDVNFFNQPYLLQAQVDEQLHFQQQQQQQQQQQYHQQHQLDFSSVVPPSGFTDPFEPQQQQHHDEAIEPPRFHYDPPPVEFPDYSSFNFNTLPHRPAQQPIAGEPWMPAVDNTLFAPALPETIKNEIDEAAGIPIILTQPTDTMTMATLTQTQNPSMLEPVAAAATAGSLAPPSRHSHAPSRPPRRLLPAASLRRPVHRQPEVRARRSPVIQMSPQAAAERAAKDRFLVQSRREGVSYKDIKRLGNFKEAESTLRGRYRTLTKEKKDRQRDPKWNDLDDHLLKEAVRVLAHGQHPDRAKLSWMAVSVYIKEHGGYEFGYSTCHKRWMRFEAAGQLGDTGYDDSWEDEDEEDDHTDEGYGESQVDEHEQGHESNDQNEDDDEDEDENSEVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2G6</accession>
    <name>A0A2T4C2G6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1392267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2G6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015594600" evidence="2">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="115" mass="12130" checksum="5E7C691841EA59B7" modified="2018-07-18" version="1">MSLRVASARPGSSLLLLLLLVLRPRKACVRSGATGDTRAARCTPSAVDFEEPDLRGSRLTAPSSLARSSPIAPPLALESSADPAESNRQPGLASATLFVEPEPEPEPEETRQIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2K0</accession>
    <name>A0A2T4C2K0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1297345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4899536at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="21391" checksum="247551FEDF41929A" modified="2018-07-18" version="1" fragment="single">TKGAPSSTETAWGSLTDEADISQPTSRTRSSHSCPNVFCLPISPWTKTEAHQTSTSTPSTHPSSSTASSKISASNTSPSACVPVSASKTPSPWRFNFTDACDADTPLAEDCRATLTCETSLGLFPTCDRGRCACLAKECFRKSMCETLRQCRDYDEAVCVRDGDSSVGVCGCRARVTGCLFRESPHTWCGRASNCTERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2T3</accession>
    <name>A0A2T4C2T3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1402399</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2T3"/>
    <dbReference type="STRING" id="983965.A0A2T4C2T3"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="15">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="14">
        <location>
            <begin position="138"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="330" mass="37800" checksum="7C8C3BC452679EFA" modified="2018-07-18" version="1">MAPARQQPPPPFAKDEKVLCFHMDMLYEAKIMDVQPAEKPNEGYRYKVHYKGWKNTWDDWVLVDRIRPFDDEHKELAAQLHAQLKNSMQKTSKVPKKIVKNGGGGGGAGAGAGGESARGSEERGSAVTQGGRGGRRGKDWELEQEDAFHSKPMINISVPDHIQAMLVDDWENITKNNQLVPLPHAKPVSKIFEDYLAVERPRREEGSSSMDILEEVIAGFREYFEKALSRILLYRFERHQYMDLRKLWDNADENAQYKSVCDVYGAEHLARLIVSLPELLAQTNMDQQSVSRLREEIGKFTSWLGRNCETYFVSEYETPSQEYIDKARSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2V0</accession>
    <name>A0A2T4C2V0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1262559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2V0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18630" checksum="5CF64E233CB9EB8F" modified="2018-07-18" version="1">MSMPSSSPLPDGPMLRYDSWSSGPVIDVLLLEKCLSNDRTEDNRTSSCAGLLHRRKRLTTVSVKVVSHHPTNTEGPVPGRLERLGLLLVSRVLSANHGPRAMRIWCVPRTSSRFLCPARSLVPLEFPAAWHRLTRRLQYLKMLCSWYMLLLRQTDRQDRQRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C314</accession>
    <name>A0A2T4C314_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_333137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C314"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="147" mass="16131" checksum="80B5A27AB7A5CDCD" modified="2018-07-18" version="1">MCIIQSRPRRRPRPVFSCLFRSAASSSPRPCASIPLTCITWPSLVLGGNSRWSGADKSGFGLTHAVSPRIVIDSYPVPHTSVLCFSSQKPLERRLIVRRPGLPPRRRSKTAAVIKRFPLLTQTLVLSVLPYPASRPSSAPSSPRSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C416</accession>
    <name>A0A2T4C416_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C416"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="289" mass="31870" checksum="688D4CD0FE8FE7B9" modified="2018-07-18" version="1">MSASNLAKEALSTWETNAEFWDSGIGETGNKYWKQLQRPSLERLLGPTLSKNSGCSALELATGNGLCARWLADNGASSIIATDGTFGMLEQASKYMDEEKAGKISFRKLDVTEEGDFVPLVEKAAKIGGFDIVLMNMAIMDVATLDPLADALPKLLSKDGVRVTMKGSSSFVATLLHPVFMTSTYSRTVEVTYDPQTGDQIITRSKSIREYLHVKPSKGVFVVGQETRQYYFHRPLHELLGVFFERGLILDALEEPSFTDEDGDPGKAYATVNFPQLPPILSLRFRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4L2</accession>
    <name>A0A2T4C4L2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1253681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4L2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="115" mass="12235" checksum="BE8CC77EC5615830" modified="2018-07-18" version="1">MLRAPAQLSAAAEAANARATQTTSTQRIQWSSFFLAFSLHLASSIVLYLRIPASALHPPFPSFIPSRFRVFSFSSSPPLKAPLSLRLVALACLTAANGFNSPPGPHLATLPAMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5C1</accession>
    <name>A0A2T4C5C1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1332629</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C5C1"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="399"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="550"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1442" mass="160055" checksum="FD68148F8E883453" modified="2018-07-18" version="1">MCCSGARRGGSTSRNHGVSASSLLSTISSPSLSSSMPSFASALLRAVVPNCWLAATPRNPELAAGLMPREADCPMPASGLDATARRIACRHPQQPRVAATGREIISAAFRRRLLRTLATAVDDFKVEAMPYNRLSNSSIPPFEIHAFNPASPLTIPEPGAPKAQTKTNTYGIPGEPEDMLMVFDACIRVGKLERAALVLKRLSATGTTTDEERIVLNNKYLRASLNQMRTTPDRKQAEQLHKWYELQIRSKNLPHTAETIACMLKASLLSERGARLERLVKRYMGMAPDEAGLRVLSMDEILSDQDLAVITRICPTYNFAPDEGDLADSALSPENSQEAEASSTLNTEAGQSSTSGSVPELIPTPQRGEGLTTLKKGLGLLLGLQNVDISKLPYSDRVDIQLQLERDTISSAIEKWRLDNKTLQKRGVTTALAPSHKEGSMSQNLASWMSAMESRIYQELRLIEQSEAKKSKSDKDLTRCIYGPFIQQGDPARLAAVTILSVINLGTVLGVEKGLPISRLITHIAKAVQEDIEMYQKELAERKARRERKLRFVGDKKKSSKKASSKDAGKEEEPPVLVDTTEQQSALEENSRSPWSLQIKAQVGSILLQMLMESAKINVVVEGPTSKELISQYQPAFNHQSILRKGKKVGALFFNTRLIEQLKREPVGDFIAKHIPMVVEPKPWQSFTEGGFLDSKTSFVRVKPGDVEQKLYSTAAIKRGDMTQVFKGLDVLGKTPWIINKDTLNVMMDAWNSGEEIANIPPLNPNLTIPPEPDSSADPLVRKTWIRAVKAIENERSGLHSQRCFMNLQLEIARAFRNQTIYFPHNVDYRGRAYPMPTYLNHMGADHARAILKFARGKELGARGLRWLKIHLANVYGLDKASFDEREAFADENVANIIDSATNPLNGSRWWLQGEDPWQCLSACFELKAALELPDPTKFVSHLPVHQDGTCNGLQHYAALGGDTWGAKQVNLEPGDRPADVYSAVADLVKQAIAKDKENGNAFAEALDGKITRKVVKQTVMTNVYGVTFSGAKKQICKQIDALYPDLGDQVGIDNMLLSTYIAKQVFQALATMFKGAHDIQYWLGEIGGRVCRALTPAQLQQIVDQYGEGGEGGSRISKARSATTARKKVEFDDLIQQFRSSVVWTTPLRMPVVQPYRKTTAREIKTCLQAVIYPMSDQTDPVNRRKQLQGFPPNFIHSLDASHMLLSALECHARGLDFAAVHDSFWTHAADLDVMNEVLREAFIRIHEEDVVGRLGAEFAARHHGSIYLAKIDPDTPVAKKIKELRKASKLSPKEELLLEHKRNQLKLSGNPWDLEAAKKIVTPASVYEEMMAAEVDMDIQEDAKDIGLGAIPEESQLLDAEDLEAQKDRSTVSAEFTERLMKDMHSSFFETKVAGEKSASSQQKKKKTPLPVWLPLTIPEVPKKGDFDVKRLRESKYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5I0</accession>
    <name>A0A2T4C5I0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1308759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5I0"/>
    <dbReference type="OrthoDB" id="5226162at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="230" mass="25061" checksum="95B011E9C87B6D58" modified="2018-07-18" version="1" fragment="single">MTLFGGLGSRRGSKPRDLHIRKVSFSGCSLASTSDRSFSSDSSTSTIRGLTPRLGPNSGTASSFDAFSIHSASQPPKRLHDRAFIPANQHHFNAAPTFYDSDDTDSSDLEASERDFDGEDEDQTQFTMELPHASPVNHHNDEGDEPRDYFFMHINQRPSLPRSRWSESTISSVESLDDLTPSTSMSEPASSGAKADAEQAEAAGESAPRTGTSNAVPKRPTFRTIDSFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5S6</accession>
    <name>A0A2T4C5S6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1469990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5S6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5S6"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="339" mass="37841" checksum="0FC3923419DC1A45" modified="2018-07-18" version="1">MSPTKPRAILGLMTYGPPTSPDNRVTTIEEFQTHLDAFQKHGYNELDTARIYSNGDQEAFTAKAGYKERGFKIATKSYPLVPGQHTAANLRKDLATSLAELGTTCVDIFYLHSADRSVPFTETLEAANALYEEGKFKQLGLSNYTAYEVAEIVMLCHYRGWVKPTIYQGLYNAITRNLETEVIPACRRFGLEVVVFTPLGGGLLTGRYKSPDDDEQQGRFSKNTFLGPILRSMYFNESLFKALRILRVAAERHKLTMPEIAIRWIVHHSALKFAKDGGNDGVIFGISKISQLDQNIADLQKGPLPEDVVKALDAAWVIAKGTSPNPWHTSLEYTYEGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5U1</accession>
    <name>A0A2T4C5U1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1421982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5U1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5U1"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1009" mass="109152" checksum="B0D7C21E812378C4" modified="2018-07-18" version="1">METSSPSWDYTAMQFGPKIPCPFPTVTASFYHHVRSFPDNVALHDLSGETTRMITYRQLAARAQALAAQLRGLGVLPNQRIPLVVKRSAEMVVGIWAILSCGAQYVPLDGGVVPDSTIRHVFEQLGGSIVCCLPSTVHRIRDLCPGATPVIIEQQQLDNEAHDERWIDLATPDGGCYIIYTSGTTGKPKGVDVSHKNVANLVCMSPGNLGIRPGNRVGQVLNISFDMAAWEIFACLCNGGTLVIRGSKWEPAIEQLDTLICTPSILSKYPPTKYPKIKVVATAGEPTSQDLADLWATHATYWNCCGPTETTIVNTMQKHVVGDGLSIGSPTPNNNVYILDDNGSPVPAGEPGTMWAGGSGVSRGYVGLETKTKESYIPDPFTNDGSKMYCTGDLGRWRPDGSIEILGRVDDQVKVKGFRVELDGVSSSMASAPGVTRACALLIDGDIHGFVIPANQDSEAILQHTRRLQPYYAVPSSLHLLDEFPTTANGKIDKKALRLLATVPASPAISESSTVFSSTFQSAILPRKDSATSDSLDGLRSVSSFSTLRAASEKGEEDKVNEKIDLSASIPEKKWPKPWRGLLKRVLIVYRVLLSFVGLINIGVLIAVLLLSPNVEWLATITAANLVAGVLIRQDAVINVLYTLCCSVPKSFPFWIRRRCAKIYHLGGIHSGAGICATAWLLASTIQATVARFQLHGRPSGASLANLVVSWLLCALCFGILASALPMFRKAKHNMFEKMHRFMGWTALALFWAKTVVSVYESTPAGGDLGKALIKTPSFWMLGVATCSVASSWVFLRKVKVNAEPLSDHAIRLHFDYTVPVNGSFTRVSHRPLLEWHSFATIPAPQPDVENGLASGYSLVVSNAGDWTKACIRNPPTSLWVRGLPACGVMRIATLFNRVVVIATGSGIGPMLGHIGQPSCPTQLIWSAASPEKTFGKRIMDTIKGTIPGAVIHDTRTQGRPDLVRMGYNMAKNFGAEAVIIIANEKITKKVVYGLETRGIPAYGAIWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5W1</accession>
    <name>A0A2T4C5W1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_306733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5W1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5W1"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="33"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="638"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="81323" checksum="5D54CBA1EE25E0D5" modified="2018-07-18" version="1">MASSSNGQAGQGMGSRALLDKVDKLRELGISGIVPLPQMVVVGDQSSGKSSVLESLTGFQFPRAATLCTRHATEIVCRREPTESVVVSIIPHNPSPEREKLVRGFRRSTDKIVSDDFPKIFEDAAKVMGIKLSENDGNGGSAFSLDVLKVEISGPNADHLTVIDVPGMFETVTPGVTTESDIDLVKNMVKRYIEESRTIILAVVPCIVDIANQKILRLAAEADPQGKRTLGVLTKPDLCIENATKAVVCDLVNGKRRDLHLGYCVVKNLGADDVSGSMHSRNQQEQSLFGQAPWNTLPSDRVGITALQNRIRHLLMDRTRAEFPLVKNEIMASLKKSQKLLEDMGKSRSTTDQQRAYLGDVASKFVTLKNFGLDAYYTRDNFFDEYDMRLITRIRTINEAFSLVMHERGHAMEFDHDSDDEIYGYFDKPSEPDEAQLAKNRALLYGAKTRIKIPKVGEGDLDDIVSDPYWCAEPEKGDMLQHIQELYLNSRGYEMGTFSSEMLSRTFKDQGSKWRPITLAHVSNAMLVVHQFIHRALEECCPDATVREELWGFLLYGNEGHAGLLKRYARAMNHVEFLLAVEFQERAITHDPRFDEKLNQLKLGGDKPASSDDDPDNDDRQQQQQPEKGPSSSLEDTTRDIHNLLQSYYGIARSRFVDVVCQQAIDYFLLRAKDGPLEVLSDKVVLDMSAEQLDLIAGEDLAVKEERERLDKQVESLTQALKILRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5W3</accession>
    <name>A0A2T4C5W3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_362210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5W3"/>
    <dbReference type="STRING" id="983965.A0A2T4C5W3"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="568" mass="64888" checksum="C3216733C9B02A36" modified="2018-07-18" version="1">MEIQRPEFVNYTFVGYVPSPDGRGTLSLLFSCLLTLSLYVWSAIHLDLPPYGESDIEYAYRYVKWSVLGIFGPELVIWAAWRQFISARTLTKFIKKSSNNGRRDVDKGRQWTMVHGFYARMGGFVFDTTTPEMLHGPPFIPQRRLHVTPRGIQLLAKCGLMPDISVEEIKDKSRTDGSGNLICCIQVDWMVVQAIVRVAVGLPITPLETNTIGHVVCALINYALWWYKPKWIKEPTILRGDWTREICAFMYMSSQVSQENRANRDVLRDFGVKTEMSGVLYTPSHFSSEDIHFHEGSEEDIQPRPPNGALATKGYMAFNDDFEPSGQTLHTEDAVTKITTSAMREVRWQLACDAIERYPAIRERLDVPPCDQAELRYREAHRLYPEMPDRVSQHPSGHKPSDHLKAGSSTNTSWWCVSEELVVERPRNWPGDDLLHHMQGHLMGIILWSSSTVYGAVHIARWNEIFPTTMDSWFWRASGVYIVFSGLLWSLLNLMGHLSGSVWWFWYGILEGAERKRSHVLIYVLCCIGGTCYVVARVYLVLEAFVSLRSLPASAYDSPSWILTVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C641</accession>
    <name>A0A2T4C641_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein-like II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1462797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C641"/>
    <dbReference type="STRING" id="983965.A0A2T4C641"/>
    <dbReference type="OrthoDB" id="124329at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006:SF2">
        <property type="entry name" value="ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006">
        <property type="entry name" value="THIAMINE-BINDING PERIPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13343">
        <property type="entry name" value="SBP_bac_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015395009" evidence="2">
        <location>
            <begin position="23"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="365" mass="40638" checksum="808FC58F84C011FD" modified="2018-07-18" version="1">MALLKQLQAALLGACLICSTGALSQGTELETRSLDEIHQSAKNESGILNVYFGGSSQAAAEPMLNAFRQRYPDIAINITADLSKYADSRIDRSYIEGKPFIDVALLQTVHDFPRWDKQQRLLHYKPANYSDINLAIKHIDGAYLPVNYNQFGPFYYDSTIVKKDQVPKTYADVLDPFWKGKLVLTYPNDDDGVLYLFSLIIERYGFQWLDSLLKQDVMWVRGAAAATGAIISNHASRKGSRVLTFSALGGFTPSTSFLQVSQPEAPDQFMTWAQQAAIFASTPRPESSKLFISFLLSNEWQSTLTASGGPSVRTSLTGANNVFMANNTQPSGYISFMSRREDVEWWRMQMETYIGLAVGPDPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C667</accession>
    <name>A0A2T4C667_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucooligosaccharide oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1470055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C667"/>
    <dbReference type="STRING" id="983965.A0A2T4C667"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015568202" evidence="5">
        <location>
            <begin position="18"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="485" mass="52476" checksum="67C1C0945B74875B" modified="2018-07-18" version="1">MYSLALCLLAAVSSVSATTAQTCKTLDAKIPGRVSYPDSTAYNSSISSYYSGQERDLNPGCIFRPTSTAEVSQFIKLVTSSGNTQFAVRGGGHTLWPGAANVDGGITVDMRAMNSLTLSDDHKIAHLGAGAVFSDIYPQLTPYNLTVMGGRVPGIGAGGFVTGGGITFLSRRNGFSCDNVYGYEVVLASGKVVYASQSSNSDLWLALKGGSNNFGIITRFDLAAFPMGDMWYSDLSYNYTDSVLSANANAFSNFMKPANYDSAAMMGMFVYYTNQGFGISNAMWYIEDVASPKVYDAFTQIPNLGGVSELATVDKVVNNFGENLPATTGRSYQLTFTFNNPPASVYLQLIQIWEKRITALSKVEGLFIEFLFQPQPVTNGTNMFGLTPGKTDYVLIDMTAAYDNASDDALVESVINDIVKQQRALLKSSKYLVDFIYLNYADISQNVLSTWGAGNLAKLQAASKKYDPKGVFQTRSPGGYKLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6E1</accession>
    <name>A0A2T4C6E1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1332281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6E1"/>
    <dbReference type="STRING" id="983965.A0A2T4C6E1"/>
    <dbReference type="OrthoDB" id="4161406at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="102" mass="10600" checksum="7FCC13A30A5CEF58" modified="2018-07-18" version="1">MIQPLGQFGAGVGLCNVPLYNFAQCHDQLKSQGTQVIGSVLSEGTVQFDNIPPACMDLNADLIGACEGSGPRPEPCGSACMKYMGLSHQQLDELSASLSAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6F9</accession>
    <name>A0A2T4C6F9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1438770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6F9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6F9"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="140"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="284" mass="31543" checksum="8EB992FB24A59939" modified="2018-07-18" version="1">MSAGEKVVYQGNCHCGRYRFQLSVPEIVSAITCTCSLCVKKGYLWLIPAEGSFTVLRDGGCLVDYQTSTIRDKFCSYCGSGVQGEHLTGPLKDKFVINIRTLCEPYVNPFKLETALRVVEAEGDTRSIDPLPCEPGEAPAKALFSCHCGDVRATLLGPLEHEELKEDNCSKCVRMAYIGTYPAKDNVRIYGRDRVFEYLTGGKFTGSTFCNTCGVHVFSNVYGPPISVFDKLPPERKEKALAVYHKNMAMQPLNVRAAEGIRLDDLRPLINRQDEGTEGYELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C705</accession>
    <name>A0A2T4C705_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integral Golgi membrane transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_18515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C705"/>
    <dbReference type="STRING" id="983965.A0A2T4C705"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB77359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23168" checksum="E44FBE8BD918DC5C" modified="2018-07-18" version="1">MARRRRPPRAGALSELQPLKIAAQIATLQALYYLAALVLFLFTTLVAGMPFSFDLILTWDRVRGDTTQGWLMAFIWLLDGGFCMSVAIVILIARSKLVPDFALTIHFLHLLLTTLYTRSLPRNSMWWLAMAASSAAAIGLGMWGCRYRELQPVFFLGGRILGSGTSSSTNNNNNNTTRSAAPGGSLPPDLEDGMGGSSSSAGEYEMSRIKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C726</accession>
    <name>A0A2T4C726_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1353329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C726"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="923"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="982"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="275"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="573"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="852"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1164"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1419" mass="156105" checksum="B89540F4FCAD586F" modified="2018-07-18" version="1">MASHSDESLFLSLTSATSLAFILLGSYRLWALRHDKIKVESNWLVVLKPLVALLLPAILLSDLVLALSRDRTEWLEIASRSAALVASAGLVWLSIAEHKRSIRPSSLIVLYLMLTIVFDTFELTYPGFANVRNGGRSHAFLVAEIASRVAILVFESQNKTSILRSEYSKTSPEETAGLISSLLFWWLNGLLSRGNRSMLRGSHLPPLDSELEAEGLRQKILETWENRSNKSESILTLLTVLLRCLAAPFFAATFPRLGLVIFRCSQPILIEQAVRFVQGYTEGDDASQGYWLVVAAAFVYLGQTFSHARYFHLTNRLELMTRASLTTLIYNKALNIGSHAAETGKVITIMSTDVDGAVEAGRMVHEAWAKLFELVLGVVLLVRQVKWLAPLPFVIIVFCSQVSRYVAKNIRVRQKGWNMATQRRISVLSSILGSMKSVKALGVSGATMNYIDQLRGDEINASKNVRFMNAVYNASANALGIFAPVATIVVYAAVARLQGSQLDVSTAFTTVAILALVTEPANMIMTIVPNAVATSANFERIQAYLLEPSRTDKRRVTSSSSGAPRAHPTDAAVRLDGVTVDSPTTKDILLHDVNLVLLRGSVTTCSGPVGSGKSTLAKVILGEIAPSEGTITISSASIGYCDQQAWLPTGKVKQIVGGFSTAIDQERYDAAIRACCLDHDLAGFPEGDETVVGSRGINLSGGQRQRLALARLVYSLHDIVVLDDPFSALDGNTENTVVDNLLGPNGWFKKNTTAVFLVTNSAQHFHVADEILVLEKGRIATRGSWDELQSSLSELTKFTFAQAEKKPEAAAKAVKAKSQSTADAEEDLYRKTGDFSLYSYYLKSAGAINVMLLLICTASYSFGMFFPQYLLKWWTEGPPDRSSYYMAGYIALAVLAWVATNGSTWSTNIMIAPRSGALLHKSLLRTIFGAPLLFFTTTDIGVILNRFSQDISYVDRQLPFALITVSTQTFKMLFQLVLILNIQRWLTVCLPICAIAVYLIQRIYLRTSRQLRVLELEYQSSLYQWFLETAEGVVTIRSFGWSPAAEEKNVEALNWALRPRYTLMCVQRWLSLVLNLIVNGIAIGLIVLAVRWRGTTTGGDIGAALNLILAANATLVRLVESWASLEVSLGAIARLRNVERFTPQEDRPEEDLVTYAGWPTKGEAQIAHLDAGYSPEHQILHDVNIDIKAGQRLVICGRTGSGKSTIIAALLRLIESTGVLKVDGQDLLRTPRSVVRQKCFITITQEPFLIPQATLRFNLDPHSIVSDQVLQEALQKVSIWRLLSSKSDSAADVLNSELSALPALSAGQSQLLAVARAIVRKHALAAESDCYPVGADAPKPILLLDEATSSLDAETEDYIYGVLEGEFVREGYTAVIVAHRLLVVLGRWRPERDRIAWVEDGRVPRVGSYEEILELARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7K5</accession>
    <name>A0A2T4C7K5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1329946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7K5"/>
    <dbReference type="STRING" id="983965.A0A2T4C7K5"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="283" mass="31312" checksum="5202F82A35AE5BEA" modified="2018-07-18" version="1">MSSIEEIQAERQTYQEQLDLVLGQIRDDPDNVELKALHSELTEFIRLLDENIADLKSKQAPKPAEKPAAPSPEPAKWSKENHPAFKKAAPPAEDKEEPIVHYQVNDTVLAKWVSGDKAFYPARITSITGSSTDPIYIVKFKSYDNTETLRSRDIRPITNKRKAEGPPSASTTPVATTPAAPGVVSSAGATMYPDAQKEAEAEKNAAKAPKAKKIKATKELEAGKSKWQDFNAKSKFAKSHKKDSMFRTPEGIHGRVGFTGSGKTMRKDPTRSRHVYQVNEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Z1</accession>
    <name>A0A2T4C7Z1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Z1"/>
    <dbReference type="OrthoDB" id="4138121at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="10877" checksum="4AC98865AB9D6D3E" modified="2018-07-18" version="1">MSPFWYALRLIQAFEDRIIESILRQPGFHRAVGRIHRAIHEKQHGRNPHEPLAPGEATADPNSGGRADGFFKHFLSELKNQARGRPSDISDKPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C827</accession>
    <name>A0A2T4C827_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1438161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C827"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="529" mass="59100" checksum="747BD90EABE5DA5D" modified="2018-07-18" version="1">MLIKLGRSPDEVITVSPADDARILRRIDIALLPLMLSVYFLQALDKATLSYASIFGLIDDTDLVGDEFSWLGSIVYLAQLLMQLPLAWALVKLPIGKFTSAMVFAWGVTLACMTWAHNFGQLMAARFFLGAFEACVGPAFVAITQMWWRRREQTLRIGSWYCMNGLTWVFGSLITYGLASIDSHLKPYQIIFLFFGVVTVAVSGAMFFWMPDSPTEAKFLSDEDKILAIERLRNNQMGVMSREWRYAHFFEALRDLKTWLWVIMIFCISVPSNGISTFGPLIIKSFVTDPYRTILFNVPVGLSHVLAVSLSAYASMKWKVKGPVIALLCIPPIIGFSIMLHFPHDIDHRAILLAGYFCLSTFTGITPLIYSWSAQNTAGDTKRKCTSAMVFIGSSAGNIFGPLLFTPDEAPSYSRGLRANIIFFALVLLLVGVTSLYLKYLNSDHAKRRVALGKSAVVLDMSLETAEEVERMEALERAMREGTQRLSQENGDTRLGGDEENGVQPDDVKGCKAFADITDLENEDFVFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8C8</accession>
    <name>A0A2T4C8C8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1421569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8C8"/>
    <dbReference type="STRING" id="983965.A0A2T4C8C8"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="280" mass="30697" checksum="E28B83D568FC18A4" modified="2018-07-18" version="1">MPTSPIDISSLVAQSDLTPDLKNRLSPLLDAAINSSSSSSSSPSNIEAAAAAIDEVCPRNQDAEGFLWPLWDLLIDIAKCIPLDDNERISSLVGIVTSLQAKQQQGETVEIWGSSHDLWSDLPLFGAVMREAWNGNPDFEGSPEDAAKIAEWLSLNSFAARLLGASAAFWTNFALWELRDGLEEPLSNEEARDTHLTTASEWMIRAGKVLYDEVRKNVELDEHDVRALAPGSLFEGGSPGSSQQRWTFWKKRLQELSAEAGAEAKTRTQKALEVMESLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8J4</accession>
    <name>A0A2T4C8J4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1227295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8J4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="84" mass="9925" checksum="6C4B188F61AB1FDA" modified="2018-07-18" version="1">MLCFFCCCPQRWVRQGTSMYIWLLWVGQGLPTWGLRGSTSFVKLLPLGTLEYLFGYCLHKSMVQFFLHFQIFVRFFSCAVTFCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8T7</accession>
    <name>A0A2T4C8T7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1227975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8T7"/>
    <dbReference type="OrthoDB" id="10620196at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="137" mass="15204" checksum="864EA85D98569F93" modified="2018-07-18" version="1">MEYTYLYLDALPGDLDQPEASGLGFKYRDGTWLHKSGALDPLCPLLMYKYGDCTDASTLHARRESQFERWKTKDKDDEKTNCLHPTKVSVVDSEPSSAISEAGRAKGLDACTRSRHKGLIQQVTCSQASSGRSLVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8X0</accession>
    <name>A0A2T4C8X0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1389792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8X0"/>
    <dbReference type="STRING" id="983965.A0A2T4C8X0"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="444" mass="49305" checksum="ADC8722A4E2F8C31" modified="2018-07-18" version="1">MVQTQIQIPELGLLPTTFSKVKPAVTETIREITPPTDHLDTWSPDSWRTKRAAQAVEYADKDALEETCAYLRQLPPLVNPSEIEQARAQLYHVALGRAFVIQGGDCAESFHDIKYDVIKKKVELLRRQSEILEEALGMTVIPLGRIAGQYAKPRSNPFETLPSGEKIHAFRGHNVNSEDPNRRQPDPNRLLLGYFYAAASQNTIRHVSTHSSSSVSSAAGKTPGKSFLYTSHEALHLPYESALTRDRYNLSATTIWLGERTRQLDGAHVEYARGLRNPIGVKVGPTATADEVVAILNALSPDRSQCGKITIITRMGCGKVRSVLPPIIRAVQLSGHVPIWMSDPCHGNTFATSTGVKTRRAEDLLQELKETYIAHRSLGSRLGGIHLEQTGEDVTECLDGQTNTCEEDLGQCYQSLCDPRLSNEQALWLVKQFGEFVKNYQHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9P8</accession>
    <name>A0A2T4C9P8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1399466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9P8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015693226" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10529" checksum="D11D440245DDDF16" modified="2018-07-18" version="1">MLAGCLPCCPFLLASCCLLACLLHICGTRHGRDRVAPLPVISGGGIPERRCFCIVLMLICCVSGLSDAMGRRCLCEPKSARPCSDGDDDDAVLILLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAZ3</accession>
    <name>A0A2T4CAZ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1420786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAZ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CAZ3"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="620" mass="66750" checksum="1DEDC77D20A792DB" modified="2018-07-18" version="1">MASLSPMSPPHLSRSLEASSAGSDKSHPAVKTEHPPPEAPLAAPRRAPLPSQPKSAAAPQAPFVRISLPPVNKMSMTAVISPSPQTEQPQPKMSMTSKEWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVGELEEMLDEHKKAQDTREKEMTDQIRNLELDVQSFRSRCLLLESMLERERQERIRAEMQAETLSRRYEQANFRSESLGSLPPPYGRQHQQQHQPQQRHSLSDSRMGQQQNTSRHFSISQIVTPPDMSDMQSPHEPSETHLTCGSCSPNGRCACAEEVLASVVTGCGKCGFGTACQCLDDSAKVSGQGPELKRPLSPSGGVSQEKRQRPMAAASTETDFTSLFSRPSQQQPLPQPSSIISQLPSADTLPFRDSCGFCKDGTYCVCADAAMATPAMTPADASPPVTRQTRTPPPLESDVVTPLPPMAMEMTADGAVKLPRRKPARSSQPQPQADSTAARGSCGPNGPGTCAQCQADPKSGLFCRLMVASFNREQGGASAGGGCCGSKGPGGGCCKSKPSQEKITLPSLPSLGLSCADAYQTLSSHSNFEQAADEIGSWLPKLKAHPTSDPRAAHAGRIPIEVEAASIMSVLKEFDVRFGREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB85</accession>
    <name>A0A2T4CB85_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="2">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1420871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="2"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB85"/>
    <dbReference type="STRING" id="983965.A0A2T4CB85"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="103" mass="10968" checksum="02E1505AB4840F51" modified="2018-07-18" version="1" fragment="single">MAEEQTSAQGSSPSPSTTIRVGTRNSPLALAQADIVVAALQAVLPAHYSFPIHGMTTTGDRDQSTALYNFGGKGLWTTQLEDRLAADELDLIVHSLKDMPTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB92</accession>
    <name>A0A2T4CB92_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_353282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB92"/>
    <dbReference type="OrthoDB" id="4892500at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="284" mass="31552" checksum="42F95CB3BA5D7A2D" modified="2018-07-18" version="1">MEEEKEVSPVWFAITVTMAVFFLFNVLMAAIWVLLPDDLCFPPFSAHQAALRAARYRSRLPQAHAYYTAQSYYSLRSVYVDGSRSRQVTVFNGYVETDEDFDAWAYWATDSEETLGGSAFGRRLHQSQSQSQSLRSGQTQAQFQYYRQHDLHSTAGSSARETGYQLPSSSSSSAASIVTGARGHAARLALGMRSEYNPEPRMESSPNEAPPPRYSQIPREVNCSLHPRAYPYPQTPPPVRTLGHGGSTATIRPVVENHRRETGASQTEGYVKPKAESIGEGDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBJ3</accession>
    <name>A0A2T4CBJ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBJ3"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF26">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY OXIDOREDUCTASE (JCVI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="252" mass="26920" checksum="AFE4A07D200D0F82" modified="2018-07-18" version="1">MAINTANTVYVITGGNRGLGLGLVRSLIARKNTTVIATVRNEEAASRLAGEIPAALKGPGSTLFIAQLDFSTVSSPNAISDAFKFDIDHIDVLINNAGGTFPMVSAAETTAQDLQDAFQVNTIAPLLVFQALWPLLQKSSRPRLIMMTSSVGSIADMEPFPGGAYGPSKAAQNWLTRALHLETRNSGLVTIALHPGWVQTRAGQLVADQWGFPSGPPDSVESSVEEMLKVIDEASEETSGKFITQKGQILRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBY9</accession>
    <name>A0A2T4CBY9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1398325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBY9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="96" mass="10060" checksum="29D0707501E6390D" modified="2018-07-18" version="1">MIVKSSALEAGRRNTTAAAGKCYLYKADRPFSPLPPSSRSSLKQNLPSSHFKKQPVLLLHTSSTKPTSNSTSWVAAVVLNLALAVAAPAAPVTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC48</accession>
    <name>A0A2T4CC48_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin cofactor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1161073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC48"/>
    <dbReference type="STRING" id="983965.A0A2T4CC48"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="242" mass="26901" checksum="53B799C20191300C" modified="2018-07-18" version="1">MADVPLLVISEYAASERRITPSWTIFQLKSKLEPVTGIPPSCQRLSLKQSSGAEKIPVEAADEDAVQLSSFPLAPYAELHVTDTRPPTARPNFTDTSGVDKYVMPDEEYEKKTDSVLAWKKTEKLGRFDPTAPSREEARIRALKEEIAQRGIVVGKRCRVGGEDTRRGEVKYVGDVEEIPNGAGPWVGVHLDEPVGKNDGSIAGKRYWEEPSELKHGVFVRPDRVEIGDFPALDDLEDMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCU6</accession>
    <name>A0A2T4CCU6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1168393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCU6"/>
    <dbReference type="STRING" id="983965.A0A2T4CCU6"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="225"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="9">
        <location>
            <begin position="411"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
            <begin position="806"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1072" mass="122196" checksum="EBC61103309BB5CD" modified="2018-07-18" version="1">MERVPAPVKAEASGPSRPSSVVLVTDKLEKPSIDERQYRVIQLENGLEALLAHDPEADKASAALDVNVGNYSDEAEMPGMAHAVEHLLFMGTKKFPIENEYSQYLSANSGNSNAYTASTSTNYYFEVAAKPANGQDPTDANPSPLRGALDRFAQFFIEPLFLSSTLDRELQAVDSENKKNLQNDTWRIHQLAKSLSNPKHPFCHFSTGNLEVLKTIPEAKGINVRDKFIEFHAKHYSANRMKLVILGREPLDVLQKWTVEFFSDIVNKNLPPNRWTEEPPFRESDIGVQFFAKPVMDTRELHLFFPFIDEEHLYESQPGRYCSHLIGHEGPGSIMSYIKNKGWANGLSAGASPICPGTPGVFEVQIRLTEEGLKVYPQIVNVFFQYIALLRETPPQEWIFQEQKIMADIEFKYKEKAPASRFTSRVSSVMQKPLPREWLLSGYSLLRTFDANLIQQALAKFRPDNLRLCVVSQTFPGTWDKKEKWYGTEYTYERIPKDQMEDWKRAMEAPSQSRLSELHLPDKNAFIPNRLEVEKKEVSKPALAPRILRNDDMARTWWKKDDTFWVPKANVIVVLNIPLVNTSAQSYVKTKLFTELVRDALEEYSYDATLAGLEYTVSLDVRGLCLEVSGYNDKLSVLLDQVTATLRDLPIRDDRFAVVKERVTRSYDNWQLHSAYQQSGDYTSWLNAEHDFLVEELAVELREVTVDDVRELQRQLLAQMHLEVYAHGNLTKGDALGATDTVLSSLKPRVLPKSQWPIIRSLILPPGSNYVYRKTLKDPANVNHCVETCLYIGEKGDRETRAKTLLMDQMIHEPAFDQLRTKEQLGYIVFTNMRPFVTTYGFRIMIQSDRAPDYLDKRIEAFLVLFGEMLKNMTEEDFEGHKRSLINKRLEKLRNLDQETNRHWAQISSEYYDFEQAHQDAAHVKPITKADMISFFDKYFSPFSSSRARLSVHLCARGSDERDSKVADLLKESGLEDVSKEDRASLDLLEGHLKTMQSVPEEKRASLLSKAKELGLPQASPELLETPSNIASAVDSAVEITDGRLFKAGLRASHGARPVKDIAEFEETDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDE0</accession>
    <name>A0A2T4CDE0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA replication licensing factor mcm4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1327706</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDE0"/>
    <dbReference type="STRING" id="983965.A0A2T4CDE0"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="593"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="317"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB79554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111903" checksum="7EBCD998B6B95A7E" modified="2018-07-18" version="1">MSTPNRRQRDSQSATPRRSTRNSEAGTPARLVSSPIFYQSSPAPTQGIDQVMGDVSSPLRQMSNSQSTQPTNGPAPSSPLRQMTDTQSTNGDGQRTPRASGGLAGESSPIRYEPSSSPGRTPRLHSDLRSESSGLFVGSSRGTPYRRGDINSDTVRTPRAPRHVILDEAGRVLREGQAPGSDAASFANRDPNTSEADVLGGAGQTLIWGTTVSIDDTFSAFKDFLRHFTLKYRMYRDGLTDAEVNAAPDAESKPYWEALQNMLLLGTTRLYLDISDLNLYPPTRKLWHQIQAYPQEVVPVMDQSVHDLMLDLAQAETMRNRPSQSSAGQQASQRSTQGSEPVFPSSDRPDEGITPTPRPRDEEPTLEDQVASSLYVVRPFGLDKITNLRDLNPSDMDRLVSIKGLVIRTTPVIPDMKDAFFRCNVCNHSVNVGLDRGKIREPTECPRALCASKNSMQIVHNRCSFEDKQVIKLQETPDSIPAGQTPHSVSVCVYNELVDFCKAGDRVQLTGIFRVSPVRVNPRQRAIKSIYKTYVDVLHVQKVDKKRLGADPTTLGVEGEEEAETDNNEMEETRRITAEDELKIRETSRRPDIYELLSRSLAPSIYEMDDVKKGILLQLFGGTNKTFTKGGSPKYRGDINILLCGDPSTSKSQMLTYIHKIAPRGVYTSGKGSSAVGLTAYVTRDPETRQLVLESGALVLSDGGVCCIDEFDKMNESTRSVLHEVMEQQTVSIAKAGIITTLNARTSILASANPIGSRYNPELSVPQNIDLPPTLLSRFDLIYLILDRVDDKTDRRLAKHLLSMYLEDKPQSAPTSNDILPIEFLTLYISYARSNIQPVISEEAAKELVECYVAMRALGQDVRAAEKRITATTRQLESMIRLSEAHAKMRLSETVTKDDVQEAYRLIQSALKTAATDSEGRIDMSLLTDGTSAAERRRRSELKDAALRLLDEMTSGGNAVRWSDVSRRLAEASAVPIEQAEFNEIMRTLEAENAIMVSGEGARKSVRRVTAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDE2</accession>
    <name>A0A2T4CDE2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1398901</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDE2"/>
    <dbReference type="STRING" id="983965.A0A2T4CDE2"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="313" mass="33794" checksum="F3FB69A8CA036946" modified="2018-07-18" version="1">MSTSQAITSLTLTSLPKLSTGKVRDLFALDDASLLFTATDRISAYDVVLANGVPGKGLILTQISAHWFAVLEQKVPGLKHHLLSLSPPASAPLTPEERALLRGRTMVCRRLKVFPIEAIVRGYITGSAWSEYKAKGTVHGIPQPAGLQLCSPFPNGPIYTPSTKAPAGEKDENISPEQAVSIVGEKYAARIQELSLAVYSAAAAYALERGIIVADTKFEFALDEATDEVVLVDEVLTPDSSRFWNAAEWKAGSEAPSYDKQYVRDYLTSSGLKGKPNVELPASVVDETAAKYRDVFQRLTGKSLEQALAALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDI2</accession>
    <name>A0A2T4CDI2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_242770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDI2"/>
    <dbReference type="STRING" id="983965.A0A2T4CDI2"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="565"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="707" mass="76052" checksum="5992965819F6699F" modified="2018-07-18" version="1">MMSSGAWNSQDQVMAAATEDEFQQFLDISAMANMGDGMQFDFQGFPDDGSHSIMGQTRQTTDAIMGDTDPSSMIARSDGLLQNHTPAMAPMPAHMMAPSASREAISNIDAQIQYLQQQKFQQQQRQLQEQQATFFVNHSHSVPPTPQSLEMTPGSAQFYSQPEQMPSRGAYDRNYHQRMAEQDMAFTPLVSPAVTPLDPHFNMESAFTVPGAYFSPLTSPALHAQNDSSSNYETTTHSNNSPVEMDLEQPAVPAVTLDLSKKTRKTQATKARKASVKSSPISKPLRRKTGPSPAMVSQVLSEVEERSLQASDHGLLPLPAASTDGSDENASVSPENLSEMPPPPIPARRSMSKSPYIHPQTNMQAIHAPALLDELHPPHPATPASLMKLPASKTKKLTTNLQEPLLSDNIESLELPESISNTPLAGDVADAQLGTQTPRVEPSMASKGVTFQSMPSPIVRATGTSSATQSPLLLPGPSSSSQRRTPQLSARNSRKRSTGSIHASPALLPRISPNIKPLLPGTPGMSMEDQASRLLMSKSNYQNILEGNQVPGVSYPSELSTNLTSKRTSHKIAEQGRRNRINSALQVMASLLPESKNKVVSGDDSDKKDGKQSNASNSKASVVENAIVHMKNLEKENVDLKSELQALKEQLEKLKGSDGGAEASTAAPSDDGKLPKISEEQGGGPDAQGDTRMDTTTTTVGEPEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDI3</accession>
    <name>A0A2T4CDI3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDI3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="57" mass="6362" checksum="15F39408FC2B8001" modified="2018-07-18" version="1" fragment="single">MGWDGMMVMGVVDDWFSPCGCMRTGLIWLCALLFLGWFYEGAGRGREAVSEDVGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDK2</accession>
    <name>A0A2T4CDK2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1350492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDK2"/>
    <dbReference type="STRING" id="983965.A0A2T4CDK2"/>
    <dbReference type="OrthoDB" id="5430299at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="569"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="680" mass="75187" checksum="B90AF5C24FE00D6D" modified="2018-07-18" version="1">MNRPLNAAPPSSQAPSTTMETIEARNARFDEISWELASRRLQVDEYWRALDEQFPDPQEQQAFLTYSLHLSLPHVANPSGVLTSARFVEMADSISFINEAERKELLPGLEWALRPWIPLGHDKTTLYRLLPAIHNLTPQQSGKFPSTDHEILDTAFLGVNTTVQPREPSLPLNRRALNLSEQSTQSAESDDIEAPGFVFHELGVLESLECDAADQMPTTFEQGVDCEGDWEPTGFCVVARLGHTGHMDGVYIIYNMNPLQENSLERKQVTHAAWGIPPSSPGEQFSCARIGSSLRDFCFGHQLVWTEQVRHPVELVWAVRSPMGGAMRGTVFTGRPPAMDDLLAACEDLAANVAAPDTAAAAADQGSHVSRSDQALWKILFGFSSDEAAEAIRNWRADFTRQTISQAAWLLAKEAKMAEGYNKEAYEYSLWRARTAQKPLSHNHNTAQGDGAKYLIKLECGSSPSTEAVDLMRFLPKKPNILNGIDDDGNTTRFCILSSSQKITFLNALSNAHPSFQPTLIRTSIASKDLSATSSHPTLGVDATLPQFRPDNSSSFSPRPAQDEYPVWYFFYGTLADAGVLSRVVVGPGDEKAAADICYKRARVRRGRLTCLGEKYLALVDADEGSVVDGWAYQVKDRAEEDSLRVYETGMYEVVRCTVEVMGEKEGVVHGLTFRLAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDW8</accession>
    <name>A0A2T4CDW8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1326683</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDW8"/>
    <dbReference type="STRING" id="983965.A0A2T4CDW8"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="679" mass="76555" checksum="2A1400B2D22E0079" modified="2018-07-18" version="1">MAPHGNKRQTSLPSGFITVRDILDRKRGVGNLLNVIGVVKEFTLPAPSRGTDWKCRIKLFDRSVEDGSFDSVTFNIFRPEHEMPNPSVGDVIVLYQAKLQLYANELSLMTHRTTDIHLYSSSEIPQPPEGALKALRPLSRKTAHSPGQVVHEYVSHLYHSIDKSSLPTEAEVQVMKARSAINTNKSKELKDVRDGTFVDVVVQLVRQPFDTGDRVTMWVSDYTENEHFFHFTYKGLDVLQGQDSYMSPISYGAGAGAGAGGEWKGPFGKRSMQVTCYDPHTSIIREQGLSAGSWVLLRNLQIKYGRNGANLEGFLREDRGSSSQKINIQQMDATDTDAPDPRLKEAIRRKRDYEREKKDRLKDLSDAAVAGQKRKSQLAEIEPASSNKSKNSKKRKQGNKKTTGQNVPSAVPATASAPTTLSHVKCENEHKAISTIDSILEPVYLETDINGQQVKLRLPFVNMNYRAHVRVVNFMPPDLEDFARPRRATEYDMLSDNEEPDHDDFDSGGESTADDSTSRVWEWRFFLELEDASPSADNQGKRKTIWVAVNNFSAQCLVNMDASDLRKNQHELETLRHRLSLLWGELEEKKTLERENRRRAALANRGANQPPSHSSDDERGSAQMQQVGRASQVRTRPFACCIHQYGVEIPEEDPRRADAGEGKRWQRLFGLFGTRIAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEU7</accession>
    <name>A0A2T4CEU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1110978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEU7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="197" mass="21814" checksum="A99ED294EF8D3FEF" modified="2018-07-18" version="1">MSSRANCNTPPFPFCRNNGDKAPTHHQVSGHPVLSRMAQQQCFQLRLSLQPVARRGLHKPSRPYVRLVDALKTLEEVSLLTRSILEAKCRAATQSCSTTGKSQANHLCLRDQAMHLNAQLHTCTLSKVPFGNINTDLLLLQLPISSPTRLYERSRSAHTCKTRMQTSAVLCTCGSFVCSYYIVLGRAQGPCHSKQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF05</accession>
    <name>A0A2T4CF05_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1369082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF05"/>
    <dbReference type="STRING" id="983965.A0A2T4CF05"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="604" mass="66968" checksum="30F606201469E221" modified="2018-07-18" version="1">MDLYGTGKGGVGNNVCVVGTGVTGLLAVKNLVEQGLTVRALEQNEYLGGNWHHSLDAQHVSALPETRVNMSKETNSFTDFPMPDDYPSFPSAQQIGNYLEAYADKFELIKHIELSTAVTSIRRDEEDGVWVVSTKHTKTGDEEEREYDRVVLATGGLNVVNMPEIKGIEKFAGDAIHSRDFKDPTRYAGKNVLVVGLGSTGADTLSFLEKAGANKLYLSSRSRCSLIPRTIRGRPWDHYMTRRRDAKIRTLLRLSPNATNYFAGKAIGLVQSYAFPTLRAHPCFSGAVSGPLYRTPFVCDDLPELLDSGRVKVYPGIMGVAGPRTVVFKDGSEITDVDAIIFCCGFYHDLSLIQGEGHPADADFSMDAFEELKSAKYHNQKIQYQRLYHGILSERYPESLAILGSLTTLRPTFVLYDLATMALASMWSGTYPLPLPRAMKREIDSHYNFVVRALQNGPLAYLGLRIDVRGTYAWLNAAAGTGVIERLEGWGWEAWKFWWKNRTLYNFIMNGPNVPAVYRLFDIGRGRRPWAGAQAAIEKANQKHMEKVEEIQVVQAAQVVAEEVEAVEGVEAANEDESDETETEAAGDDVDVDEGDLVEKAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFP3</accession>
    <name>A0A2T4CFP3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_349401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFP3"/>
    <dbReference type="STRING" id="983965.A0A2T4CFP3"/>
    <dbReference type="OrthoDB" id="5151375at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="664" mass="73770" checksum="1E91DFF6BB43628C" modified="2018-07-18" version="1">MSPHVFPRADQNKEQEQETLPAPLLFLFFCLAFFTFVSRLADSLEAYKRRIVKFSLLPLGTLPDHRDGPGDDEQLYRHPVEQDTDHLLPVHQFHYASCRGDSRFANMSAPDFAMDNDKRVLYHAQVTLGCNGLRDLYSLGFMRQDTLERRINAAGKDIDLNSVVSLTAVWLREKIGRIYSSPSMALPSLKGLVLYLDGKGCSRDMCCHIFWEAFKKVDSSHANKVALRVGDITLTSFRAVVDHIYDHWNQWLLEGAGPEQTSHEKVAATGISGHFPAAKETQQRAMGGKLPYPAYNHDLVQLSKDEYNLRLQAGLEQLHKDQQPPPDHRNGTVSYGNRAPIEHCPPFDLGRASSWGSQPDQSERCTTRLQDCVCKDCHVKGWLSNIPKGGADDPDLNVDALGRPVNQNESEDKIAQRADLLAKIDRLAKRHRDPFFSETDSEDERTQDPKPLVFGPKQPQVSRPVGKGGKQVNPNLIIFSSSSSGDELEATHYNHEAANLLDRPASEVENDGNKGKTSKAAESAVSYELGRFDNDDIGVGEVDHFLADVEAGSEGGEQSSFTAPQVEGESWDKGATHEDVAMDVSLLDGSPQKDDVQALPSGLTSDIQIGCTKPLRRDPPYHPLVHDLFSARANVWVQRVKRPTALEMWDATEDSGSKDGDQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFT7</accession>
    <name>A0A2T4CFT7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFT7"/>
    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06587">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058997">
        <property type="entry name" value="YycE-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058998">
        <property type="entry name" value="YycE-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22659">
        <property type="entry name" value="YycE-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22658">
        <property type="entry name" value="YycE-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="132" mass="14831" checksum="556402723A0778DF" modified="2018-07-18" version="1">MPLQTATLRIARPSDNIDALIPFYVDGLGFEVLYRFSQHEDFDGIMLGHRGAAYHLEFTSKAGHTVGRAPTEDNLLVFYLPEGVDFEDAVKRMQKAGFEAVSSFNPYWDRCGKTFEDGDGYRVVLVSSKSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG26</accession>
    <name>A0A2T4CG26_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1369743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG26"/>
    <dbReference type="STRING" id="983965.A0A2T4CG26"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="421"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="746" mass="82576" checksum="8D80E3D27F2F65E3" modified="2018-07-18" version="1">MAFHLTTSFAGESLLSGFDWFNGVDPSHGFVSYQSRRDAEAMGLYSIDERTGVVRLGVDSTHEYSLSDRGRPSIRIESKATYDHGLFIADFLHMPPSHCGLWPAFWTYGDNWPYDGEIDIIEGVNTAHTNILSAHTADGCTQSPTIDGLYSGQLINTQCAVGQDNIGCGFHPSADDTSSYGDGFNAAHGGVYAMEWDSVHIRIWHFARGDIPRDIEEKRPDPETWGLPIAVFGGESCDVDEYFKRMRLVLNINFCGDYGNAVWGIADQCDAFAASCPEYVASHPEAFANAYWDVRYIDVYQLGLDGHRPHPGHPKNPDRPEHPDHPEHPDHHDHPDHGDQWDHPDHIGDPNPWRNGQTTTTTMTTRWTETVTAYATGHPPHSPQDNDESNDDWRDHVPAHTTAAIHPVATVAPVNPVQINNYAYLGCFYSSTDFPCFTEVADDADMTLEHCIELCRAPGKTYAGVFDSHCFCADDLDAGTRAAKREGLCDRECPGNRLELCGGLIGPRDDDGPREKFATDETPRHALTVYGFVAEERPEEPPAMAPGSSGSWRNEGENEDEGAEVEEVDVFPVSEDDSRWKGGEWEHDGENGWNGQWGDWEESPTEEPAISEVVVSVTKTVVDCPEETSTKEAVVTPTWLAPVDPKPWVPSDPPFGPPAPQHDDHDHFGHDEPPRPHEDYDHPHDPPYPPSSHNETNSHFHPSATSPDSPLNTYVLVAAASTVYGELERYLVIMGSSLLVLAMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG43</accession>
    <name>A0A2T4CG43_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ca2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1419076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG43"/>
    <dbReference type="STRING" id="983965.A0A2T4CG43"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="204"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="427"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="582" mass="62469" checksum="BD137C2DA006C0EF" modified="2018-07-18" version="1">MSSHEATDGKPARRHRLTNLLPVNHADIRRKAHLVSRQSGESWNFFRHLSWDGDKRRSQTWDGARLEAQPEGDAAGEDLTHAATYPANNSIPLRDTSTSGTGKQSGEDNHDRPLIVQPPTDTDGLRNRGRGDRDEVAAAVAAAEPVPDRPEKKKSGLIRHVQPKEPFTVANQLQRTLLNSWINVLIIAAPVGIALNYVKSVDRIAVFVVNFIAIVPLAALLSFATEEIALRTGETLGGLLNATFGNAVELIVAIIALIDNKVAIVQTSLIGSILSNLLLVMGFCFFFGGLRRPEQHFNTTVAQTAASMLALAAASVIVPTVFDAAANTPTDKVAKLSRGTAVILLIVYAAYLAFQLGTHQAVFSEQSQKVPAKPWSSSAAQPNIKQGLLVPGSVVSRGIVNKEGEQIVNPDEEEEEEEDPQLHFYVAVGLLAGSTAIIALCAEFMVGSIDAITANGGLSEEFVGLILLPIVGNAAEHATAVTVAVKDKMDLAIGVAVGSSMQVALFLIPLLVVIGWGMGIEEMNLSFDTFQVAVMFVAVLLVNYLIGDGKSHWLEGWLLICLYAIIAVCAFWYPDQDTGPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGE5</accession>
    <name>A0A2T4CGE5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1324474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGE5"/>
    <dbReference type="STRING" id="983965.A0A2T4CGE5"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="476" mass="52789" checksum="A36585BE03C118D0" modified="2018-07-18" version="1">MSTSYYISFTLSAVVGGLSVIALGYLWGFILWLSKKSLNIIPTRYQPAEKPEYEHIQILVVGDIGRSPRMQYHALSVAKHGKKVDIVGYKETARHPDLIGNPNVTVYPLAPQPEWIAWGTLPFFLNIPSKVIQQFWTLFATLMYTAPPAQWIIIQNPPSIPTFHVALFVAWARGSKVIVDWHNYGHTILAQKTLLRPLVPFYKLYEMKLGRHLGDANLAVTDAMTRQLQAGGRFNLKNPVYTLHDRPAEIFQPTLSPTARLEFLSRLPETKHHARNIVDGTLRLIVSSTSWTADEDFGMLLDALVAYATPTSEQEDIPPILAIITGKGPQRQAYLDKIKELQDGGKLPGIRILSAWLSNRDYASLLAAADLGISLHKSSSGVDLPMKVVDMFGAGLPVAAYAGFESIGELVKEGQNGCGFETVVELTQILKRLLSLEGAEELARLKKGAIEEGSRRWDEEWDSVVGPLIGVSNKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGF7</accession>
    <name>A0A2T4CGF7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_16778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGF7"/>
    <dbReference type="OrthoDB" id="4897733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="163" mass="18409" checksum="89D61B83C0B2E233" modified="2018-07-18" version="1">MSLVNRRPSATKDIEAAMPAPKAGEPVYDDVFLDVGSRGYHLQSQILGIPDPLGLFQRGAPRRNGFLGMLAVSLFGAFMWSIVLFMFYVVWRVIVLEPMTPTDAMVYGFMLGFLFVLALSVTGLDNLDRRWRKRRLLQRLEREMGERNGSEECPPLAIPAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGL0</accession>
    <name>A0A2T4CGL0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Formylmethionine deformylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1133381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGL0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGL0"/>
    <dbReference type="OrthoDB" id="5322539at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF6">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="66544" checksum="7130D4CDCFA7A126" modified="2018-07-18" version="1">MALFKAHWAVPSMMISGLLCGVAFALGHHFFYASWDSRIVQSNTEQEWNIRIGTGMAFLVKTCLTAAAGFAYTQLLWATLRSRHATLQGVDAMFGVTTSAWDFLSAELWRKGFGLVLLAGILWALPIVAVFTPAALTVQPSQQLNESILVQRLPTINTTSPYPFAQWGNEGGAGYVAPSVAVARLVSSVASQGSILPLEAPHPNSSYSLSFYGPSLSCGPLGGNAAFHAAYDKTFKEAYGSNWGMSNQAVTYFSFVPQTARDNKTGESIINWENRTLSGLQAIFAPEDLTGSLATLDNTAKVADKQARCRFFVAFPTYGSFANRTIECGLYNSSYHVDLKFENGKQAIKIRNSTRLNPVSVATTAGQGDHVLPQVAYVSIMDALGGTLMGKIVATRYGSLQPIRTQILSTVLTQARDMQNLQRGFGDTGILGAKSGSGTNLTMAETLEQLVSNITLSLFSSPELLRSLDNSTTGNVTVWTSLNEYSYNPRNLYIAYGTGIFATLAVVAVGLACIGASSNAYKASFSTILRTTRNEELDLLVPPGETSGAEPLSKDLAKTTLSFRHHPPAPGADSASTKGPAAFVVVKGEGPAYEQLDQMQDDSTLQATDTASSRDATTSPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGQ2</accession>
    <name>A0A2T4CGQ2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1450920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGQ2"/>
    <dbReference type="STRING" id="983965.A0A2T4CGQ2"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="40805" checksum="D9C7F294518C513C" modified="2018-07-18" version="1">MHELVDGIKELGLRYLMHGNTCTLPKVHDILVNERYRLVRKISQGGFGMVYSEVDLQSGTEVALKLTHTNDDYDALKGENYTYEVLAGGVGIPHVMWFGEECEYYVLVHELLGPSLEDLFDYCDQKFSLKTVLLIADQAISRIEYIHSKNVLHRDVKPSNFLMGVGRRGNILYAIDFDIRYENHPFCGTTRYASINNHNGQEQSWRDDLESLGYVLVFFALGSLPWQGLKATTDQKKQELVKHMKTSLSAEELCAGLPDAFAKYIDYTRSLRFEDKPNYAHLRQRFRRVFRSKGYKYDNIFDWTVKSFNEIHGLKDDTAVPQTRRPKGGRRKTPNVRGTLKRGRQPKSKLPVSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGQ9</accession>
    <name>A0A2T4CGQ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 70 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1428343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CGQ9"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000058">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="654" mass="71361" checksum="8D82DA7DC47686E3" modified="2018-07-18" version="1">MAAPMGPAVGIDLGTTYSCVGIFREDRCDIIANDQGNRTTPSFVAFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFADPEVQADMKHFPFKVIDKNSKPVIEVEFKGEKKTFTPEEISSMVLTKMRETAEAYLGTTVNNAVITVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDKKVEGERNVLIFDLGGGTFDVSLLTIEEGIFEVKSTAGDTHLGGEDFDNRLVNHFVNEFKRKHKKDLSTNARALRRLRTACERAKRTLSSSAQTSIEIDSLYEGIDYYTSITRARFEELCQDLFRSTIQPVDRVLADAKIDKSQVHEIVLVGGSTRIPRIQKLITDYFNGKEPNKSINPDEAVAYGAAVQAAILSGDTTSKSTNEILLLDVAPLSLGIETAGGMMTKLIPRNTTIPTKKSEVFSTFSDNQPGVLIQVYEGERQRTKDNNLLGKFELTGIPPAPRGVPQIEVTFDVDANGIMNVSAVEKGTGKSNKIVITNDKGRLSKEEIERMLSDAEKYKEEDEAEAKRVSAKNGLESYAYSLRNTLNDPKVDEKIEAADKETLKSEIDKIVQWLDDNQQASTEEYESHQKELEGVANPIMMKFYGAGGEGGMPGGMPGGAGGFPGAGGAPNQGGDDGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGX9</accession>
    <name>A0A2T4CGX9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">M440DRAFT_1428386</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGX9"/>
    <dbReference type="STRING" id="983965.A0A2T4CGX9"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="216"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="85"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="28">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PTB80788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="502" mass="57784" checksum="805BC65AF3BF7E1A" modified="2018-07-18" version="1">MAGGTPHGEPSVGSDTPRQKGKATPETLKTGCIAWVEKDGQPRRAEILSIKETKSGKHYYCNFDNFNKRLDEWVPVARIDFTQDVEWPNPEKDKPKDSKTKKAPSGQPKKSQVSKKSQKRPGKREQSVNSEATTPHPWTEFVDSQGQRKSSSVGPDAESQVNGSFEASATPGAGDELVADEKEEEAKKEDHGFSREEEIEKLRTSGSMTQNPAEISRIRNISKVQFGKHDLFPWYFSPYPEVFALEDVIYICEFCLSYYGDEFAFMRHRKKCTLQHPPGNEIYRDDYVSFFEIDGRRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMTMRTDKGCHIVGYFSKEKESADAYNVACILTLPQYQRKGYGRLLIQFSYELSKIEGKLGSPEKPLSDLGLLSYRQYWSENILDLLLGYNERDEKVTIEAISSALAMTTQDVEHTLQAMKMQVYHKSDHKIVIPERLIQQREKQKQKAKRVLDPSKIQWKPPVFTASSRTWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHJ0</accession>
    <name>A0A2T4CHJ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Anion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1321670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHJ0"/>
    <dbReference type="STRING" id="983965.A0A2T4CHJ0"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB81029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="339" mass="37454" checksum="3D3B889C34AC875C" modified="2018-07-18" version="1">MAAVIDDDALEPSLQSLLDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFNQKFGKEARLINGFDNLSAMEIDPNGSMQDLLAGQGENAEDLNAVGGGIGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALAKVSQLSSQYGPLLNGFLGSSGALPNGQNLNEMMEKLESLRGTISEVNTQFKDAELTTFVCVCIAEFLSLYETERMIQELANYGIDTHSIVVNQLLFPKKESDCEQCNARRKMQRKYLDQYEELYAEDFNVVKMPLLVEEVRGKEKLEKFSEMLVKPYVPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHT5</accession>
    <name>A0A2T4CHT5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1396277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHT5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="104" mass="11126" checksum="011D759D3DF1EA27" modified="2018-07-18" version="1">MGRLRVNNHGIGGAIRRLQDAAIAANVHVPDHPCIEPGSGVVVGLKGHQVGAAAISRLACEALALWEANPTLRLAWKLLETSRAEKGRPISPLRNDVRDHGTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIA6</accession>
    <name>A0A2T4CIA6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1417951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIA6"/>
    <dbReference type="STRING" id="983965.A0A2T4CIA6"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="8">
        <location>
            <begin position="144"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="10">
        <location>
            <begin position="380"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB81248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="511" mass="56721" checksum="02DF83E3604A1DCE" modified="2018-07-18" version="1">MADPRNSSSYSVVPQLQYNTVSGVNGPLVIVENVKFPRYNEIVTLTLPDGTERNGQVLEARGDRAVVQVFEGTPGIDVKKTRVKFTGQNLKLGVSEDMLGRIFDGSGRAIDKGPKVLPEEYLDINGSPINPFSREYPEEMIATGISAIDTMNSIARGQKIPIFSASGLPHNEIAAQICRQAGLVKQHGVTNKGVHDGHEENFSIVFGAMGVNLETARFFTRDFEENGSLERTTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVILTDLSAYCDALREVSAAREEVPGRRGFPGYMYTDLSTIYERAGRVTGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFVDRPLYNRGIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYAKYAIGRDAAAMKAVVGEEALSSEDKLSLEFLDKFERQFISQGAYESRSIYESLDLAWSLLRIYPKDLLNRIPAKILNEFYQRSQKDAKAKGKARAEVASNDRQQAEENLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIC4</accession>
    <name>A0A2T4CIC4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1012908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIC4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="359" mass="39054" checksum="2E0BE7723E9D75FD" modified="2018-07-18" version="1">MELEFGLRPGPTSTNQSAALVLHDLKVKCRGKSLGGLFARPAHGRALDGGAWLAAGGGPGFGARKKEALDLKRTFFFFSVAGEGKKQRDDGGLAVARRGSATHMRRGCGDSDMRALQRRVDGRGTTRLNAHGRWPVSDRRYLQLATVTVTVSRSKSSDSTGLAPLTNAHLLDTGSRSRQGMAESSRIEERARTRPFFSLLSSHLHSLSHLYNFSSCLRTSPPTPDPTASSTSPACIVGSLSSRCSAIDRLSRTQGGDPRLRLAAHEKIRGRAQRPLFILSLHPCLAFTKQVQVSGDRNVGWPAHAVKRRSARRHCIVVAQRLSPGCCLSSRPFAIARSTSLGRLSAVRCFNFWMQYPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIN1</accession>
    <name>A0A2T4CIN1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1427316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIN1"/>
    <dbReference type="STRING" id="983965.A0A2T4CIN1"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="369" mass="39981" checksum="797969CF743DF003" modified="2018-07-18" version="1">MADAKMPKRKETYPGDVLVTHCADSMLPRVGRMMEYAQYPQQQHNSHAGYASSAAGASLTSPTGHGINQHAVQSSPINASQQQQQQQQQQQQQQQQQQQQQQQQQQQSQQQHQPAQAPAHAMYQPQYGVPQASMQPVPYGIPGIQAAAMAATAAASGSGYPYMHSDPSMPHTSPRMPSAKKDGRPSPRMNSISQIPGRRMSQVTSPGVPSAPGMMNHGGPRPPPMPPAPAMQHPQSPEMPAGAVEESPLYVNAKQFHRILKRRVARQRLEEQLRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTAEEVAAMESKGGLDGKGEGSDDVSPGKSSDAPSGKRKSESGPSTSSKKPKTQSDNGEGNAEDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIQ9</accession>
    <name>A0A2T4CIQ9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1321766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIQ9"/>
    <dbReference type="STRING" id="983965.A0A2T4CIQ9"/>
    <dbReference type="OrthoDB" id="3519533at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="170" mass="18785" checksum="88C94CBCC031E428" modified="2018-07-18" version="1">MESLQLSQVLADLSNLGAAEPEAAAAIVNANLPITQAEFPKSDSPAPSQQQQRPSSGLRRAWSSEAAMQPRFDKMGRRILISSPKSGSAANSTPGTPQPSNYEEDLERANTLMALYNIRAKLKQQDNSSLIRAREKINALAARQQAQQFAELNMKKVEEMRRNRYSFPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIS4</accession>
    <name>A0A2T4CIS4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper radical oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1016072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIS4"/>
    <dbReference type="STRING" id="983965.A0A2T4CIS4"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015631996" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="266"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="386"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="496"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1117" mass="116961" checksum="BAF1F1E13EFE5CE5" modified="2018-07-18" version="1">MKPSPAASFLSVSLLSLTSCHAQLLQKRDLAVPPSLDNGWTYQGCFIDVGRTIGAASITDDDMTNQQCADYCFAHNFPYAGTEYYTQCYCGSSLATGGVNTTATSCSTPCGGNSTEACGGPDRLTLYKTTQITGPHVNPGPDGWASKGCYSEGTTGRALTFGYNGVPNAQMTVAGCTAGCKAAGYTFAGVEYGGECYCGKSISNGALPATSGCTMTCNGNSSEYCGGPGHLNVYSFGTTSSGTATSSGVQPAQTGACPGQPALVGKYNWYGCYTEGTTGRALSSKTYADDGMTLQSCATFCAGFTYFGVEYSRECYCGNSFGTGSKLTAASDCSMTCGGEDCDFCGAGNRLSVYSTNAPGSGTSSGPSGPPSTTSAAPQPTGFPQGWQAYGCWVDGVNGRILNQQLPDNDDLTLESCAKSCSSQGYTIAGAEYSKQCFCGNNIVNGGAKAANQADCNTPCAGDDSEICGGGGRMSIISKGAPAIEAPPGPIPKVGNWTYQGCYEDNVNQERTFFWQNIFANTMTPEQCLNQCGQFGYMAAGLEYGQECYCGDPENIKTAGATKRPESECGVPCAGNASAICGGGSRLSTYFWTGTPFYSWDFPAAGTAAAGSYEQLIGGVCIPLMTTQSITGKVTFLEKWGTGEPNSTGAYELDLSLVNQYQLAWREMHVKTDIFCAGGVTLPDKAGRQLTVGGWSGDSTYGVRLYTPDGSAGVNGTNDWQENVDILKLQDGRWYPTAMNMANGSVLVIGGETGSNSAAVPTLEILPFTGTAPLYMEWLERTDPNNLYPFCAVLPSGGIFVAYWNEARILDENTFATIKTLPNIPGSVNDPLGGRTYPLEGTAVLLPMHAPFTEPLNVLICGGSSEGASNAIDNCVSTYPDAANPTWAIERMPSQRVMPCIAPLPDGTYIIMNGAHHGVAGFGLATSPNLNALLYDPAKPIGYRITVMANTTVARLYHSEAITLLDGRVLVSGSDPQDDIHPEEYRVETFTPPYLKSGKPRPSFTITNKDWTYNQAITIKLGGPAQNGAIKASLLGAVTSTHGNSMGARTLFPAVSCAGTTCTITSPPSKYIAPPGWYQLYILDGGIPAVGVYVRIGGDPAQVGNWPKGVGFTTPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIZ6</accession>
    <name>A0A2T4CIZ6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1387942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIZ6"/>
    <dbReference type="STRING" id="983965.A0A2T4CIZ6"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="745"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="480"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB81551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="861" mass="93882" checksum="1FE0175149A192FB" modified="2018-07-18" version="1">MAICGNHVRQREQPQPQPQPQDEIVLSGTQPQHHGALPRPVSTVIFAGMSTTTTSTQPARSNFSRSLRRPSNTASTPDLASLYSQSKLLRKTSLAALTPSSLASIPDVSESYAIDSVLNEVPETTSPVAPETPSAMELSVGDAVNVPGGMAGTVRFVGTVAGKKGTFVGVELDSEFAARGKNNGDVDGVSYFTTNTAGAGIFVPVAKALRRSSGSSPQTPTPRSSGLKLHKSNSVSLTPPTSSISKFSSSVGPGARAPSPQGKKPRASLARPDSPQRRMAMSPGPRPSISAPAVRAPSRLASPTGKFTQSVRGIAGHMGDPNKAVERRPSFGGPRSTSSLGPEPLFDEEPGPIATPPLPTKSNTSLGSLSLRPPSRATTVNDEEIERLRTQLEDRERQLREQAATLAEMESSLTELQTLIEHPDGPPRRSSLDDKDATQLRHMLREKNDKIAMLVAEFDAHRADFRSTIDTLEMASTETERVYERRIEELMADIRELESRNLDVDSVAAQLKQLEELVQELEEGLEDARRGEAEARGEAEFLRGEVERTRSELRREKEKVVPHNLAAMSGDSSLAKALEQKEDEIRGLKAIIHSLSRDSIPGAEGHAPRQRPGSLIAEKDAIENKIARDNLERQVAELQQMLKEKNHREEELQHEIEFLRSSSINKSRESASIRRSSVRDSRDTIISMRSSQPRSPEPLHNRVSTLDTMHESDTYSTATESSTLWCEICETGGHDILTCTNMFGTDSAKNSKPKVDDHIEEERGHDDDDEEEQEKARREAAHEELKPLTPTGDEIHHPAVLTPGLPKEEPASVPAVRITPNPMESGPVAGKESGVLDLEKWCAICERDGHDSVDCPFEDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJB7</accession>
    <name>A0A2T4CJB7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_15985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJB7"/>
    <dbReference type="STRING" id="983965.A0A2T4CJB7"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="57434" checksum="83EB582843D8DC81" modified="2018-07-18" version="1">MPPSAAQDSSPHCRPSPDGRFIATLRPSELVVRSTETLQVTNSVRLPSGSGSGSGSPPASSSAGTSTSLTPLLWAPSSSKVLVCSADQLDVFGALHHPEFHATVRHYTSLIGGKPSLIQFGARDTELLIWSASGLKLVIVDVCGSGAIEIASPKFHQATSASRGLSVRPETGHLALLARSGGRDIVSLHNPVDRQVLRSWHPETLDAQGLAWTPDGKWLLLWESAVQGHRLLIHTPDGQHFRTITASNLLKGPDAELELGIRVCQLSPSAEICAIGDYSRDVCILRTHSWRAQMRLYHPVNIVPKDTLQVWQEKIAMDSSQARARHTFLKATQVLSPPGPASDPQFAAEVKPGCSMAAFDASSTLLATRLDDSPCTLWIWDIVAAELRAVLIFHSPVSFQWHANLRELLLITSQDPAQRGVSFIWDPLSEGPTPLVPEDYLPAGRSVRKTQVAWINRETEAPVLFVSDAEHYLLLSPSNNAERDTNPWQTAAAADHSGSEMALDSPTSACYAMDDGDGASVVDDTFSFKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK22</accession>
    <name>A0A2T4CK22_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1321264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK22"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="223" mass="24363" checksum="7F75AE60DA26D86C" modified="2018-07-18" version="1">MRPSEYPYERLDKDKAVLLVVDLQDGLYNAVRDFDPVAYKESIIAHAAIGKLFDLPVILTTSAEQGPNGPLPKEITSMYPNATFIKRLGEVDAWDNADFQKAVKATNRSQVIMAGIVTDVCTTHLALSLRAAGYSVWANAEASGSSSTFVREISNDRMRHAGVQVVSLFSIVCDLMRDWRNVPGASEVLPYLDKYFPVYGMVARAHAAAKTNGVLQPGEAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK69</accession>
    <name>A0A2T4CK69_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1388273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK69"/>
    <dbReference type="STRING" id="983965.A0A2T4CK69"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="325"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB81959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="834" mass="92656" checksum="5F1B427B19123BD6" modified="2018-07-18" version="1">MPHGLKQAWLTSILMEKMHYDDRASNPLSKNTSTSQTRRDYSLQRSQTYDKVFRDTGYQGHFWWYEYYYWYLDTWVARYAGLRSLVTWPNGLPSSQTYLLWRISTSTQQRSDAIARLPLCYSLENHLRKQHSLFDAEQLDLFASLGTTTATTAAHPSDDRTTLEAFLELNDTFCGSAPAHSAGDSFPNTSAGAFSDVSTAVSGHLSTQSDDHTSWTSTNSLFDPEQSSSSNDTGHSQFADCWEEAITKCKRLQFILHGLRSSNGPITLQPRDEPLRPLIERFVELEHQARPSAPAVTPNWAVGPDLSIHAVRRLLPPQRTCDRLLDAYFTTFESVLRILHIPDFRHDYRQFWGGSPSHCPPDLEQAFLCKFVICIALGAFVCPSLDAAVVGVVEQQRQEGSNLREQAKEWVAYGKQWLAREMMTGSQADTSTAQVVCLLALSRHTGPINAASTSSLWSPGDHDLTRVAMQMGLHRDPTILRSDMPAREVELRRRLWATMLELSLQLSLDHGLPAPISPESYDCAPPSEFTDDEATSADADPALSASLTSFFVDYGLPRTNPLVILARTQRLRLRILHLVHSPGASKAYEGTHQLSAELRAVYCAEIQRFLSFQKKPSVFQLKLLDAFTLPFVLAPHAKFAASATTNPAYYFSRRVRMEVSMLLLASQLPGPTAPDNGLGAVIPDADSMTLLATSTTISTGASATSTTSDALTALRIYCQGHLATLQWHAILALCLDMISELEDSFFPAVNGASWLQLQETIQAYITVLEQRVRNSAGANSAREFLFCSCAEAYIGAMMRGDTEIDQIIASAGYSALTLCCEIMEQGFQQRRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP59</accession>
    <name>A0A2T4BP59_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1473785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP59"/>
    <dbReference type="STRING" id="983965.A0A2T4BP59"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="120"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="825"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="940"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="953"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB71081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1140" mass="128426" checksum="2998FF5C2B4A449B" modified="2018-07-18" version="1">MPSAQHPQAKFDPIPPDLDLPSLVDRTPNFRWAQRVSRAQIRSLSQPDFEKLVAIHVIAGGKPLVIEGWDAVLPSSLFSAGWLEHSYDKKQENVRDISNGTDIPMTTGHYLRSMRQLTNQRQRLYLKDIDCPVEWREALQKVIHPNLFYLNENVTSKGGKRMHDEEVSESETTEMRAQNLMSHREMCASLGQNIMVEASRDEDGEKRGSSIWFMTESKDREVVREYFLSMLGHDIEIEKHFAQVNAWKKAPFDVYIVEQCPGDFILIPPLAAHQVWNRGTRTMKVAWNRTTVETLDLALHEALPKARLVCRDEQYKNKAIIYYTLQKYHALLQSAQKKAEMVQIGFPGFGRDVFRSSPRVKQLATDFKKLFELFTDILVDEVFAFKEKDVEFLPFDSCVTCSYCRSNIFNRFLTCKHCIRPLINGEEDAYDVCMECYAMGRSCACLSGLQWCEQWAWSDLTDNYESWRAMVIAIDGHVDLEHSPHPLEVARQRTGKKSLAQICQEALRRRPWKDITKPERELTPSDSEPGDGEGKPVKKSKKKRKKKGELQRCHVCCHPDYSYRVHSCTNPGCSEAYCYGVLYRAFDLMPQTVLEDEHWQCPKCLGICNCGHCRRAGITQPYMPKNTSLGHDTRRIADDRSVEALVDFRIHNLSWLKAAGEEGRSRDSKRMQLLREQADNAKAQDVLTQDQAEPRMHPSTVFTTQLEEAPTINGYGDQSHVLGQDGAHPPGFPLDVPNGQPRNVENAQREVAAPVAANAGEDGTADSSQYPDPSVFARQRIGMGYYEQDDTPDKILFDPYQAPSTDSLQADEPTVPEFVKKSIRAAKRKTKRENEDPEFTIRKSHHKRAKLAPESSDFLDNMDPALFADGGSAAMPTPAAPMALMNNEASAIPPAAPEGDAEPKVPRITMPQYDANEPILRHAKPRASYVEVDDLDIDELEETAVPSWPSPPLGGSSTKAQNTTNQAAHANDDGQEVSQPEGQRPDPSTREANAEAAPKRRGRPPRNLSKKASSAIAVDNSPAPRADKGKNKRRRGRPRKYLSTSFMEPDDSHEEDEDDAEEQAPKRKRGRPRKSDVSTRGTSSVEVVIPVQSQFMSMAERMALKGRSFKIGTRKSLNQSKGIKGMFDEPTPGVVLIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPE1</accession>
    <name>A0A2T4BPE1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GprK-type G-protein coupled receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_9195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPE1"/>
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    </dbReference>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
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        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
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        <location>
            <begin position="89"/>
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        <location>
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        <location>
            <begin position="237"/>
            <end position="256"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
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        <location>
            <begin position="465"/>
            <end position="498"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="567" mass="64190" checksum="0BE6EDF1AC5AED01" modified="2018-07-18" version="1">MGTELGLTADSKPEARLDSVGIWWICWSVVWTLLLLAGAGFLILKRNTPMLRIRGIGLSLSAIFLLHLFWIAVQLGYVIGPLYPGDTQYWIMGTYLPLGIGLFHGSNSRFLHIAQRQKKYLESKAQPVAKTSSKDDEGFLGRFRRLDHTAKVILLVGSGMLFQLFMTIFMYMISRKWHSSWGIPGTEVHGTDMEQKVQMGRGWEWWPSIIWQLFWAWVIAPVNLWRARAIRGDTQGWRTQTILCAISNLHAAPMWLVALYVPKMEAINHHWIPPQWIALSIWLMEIFTVFLPCWEVISHQALCQETLNTIAQWENNKTGLGKAIQSIKSRSTVVDSLKSGWKSTHSSGKASSVESILTLSALEHVLQRNPEPLQQFSALRDFSGENIAFLTSVGDWKSSFPASVLNRKSDISEETRRELVRERFNRALRIYTEYISATDAAFPINISSPELKRLEAIFEQPARSTYGEKQGANAATPFDDVARPDSANSSTGSKVDGDGVQYWGQIPDDFDQSIFDDAERSIKYLVLTNTWPKFVRDRRSSMEAFESAGSIEAGGMRFPIPYTTNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPZ0</accession>
    <name>A0A2T4BPZ0_TRILO</name>
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        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">M440DRAFT_1305117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="13549" checksum="393AB2EE415D07F6" modified="2018-07-18" version="1" fragment="single">MAKSSRSSSKKFNNQRKAASIFGPAETARQERLSAKLLELAKQAKPEPAEMKIDGDESDNAQDREDQAADETSMDVDSKKPTRPQITKKRIEKKRKKSSITFPKYSDRLAARKKKNAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQN2</accession>
    <name>A0A2T4BQN2_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQN2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="60" mass="6491" checksum="287AE0D95F749EA7" modified="2018-07-18" version="1">MTPLMSRRSGISESPDPKPQELVSCSPALGQLPTHPFHLSEQPVSFLTKDAFDDGVSPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRH9</accession>
    <name>A0A2T4BRH9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1343115</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRH9"/>
    <dbReference type="STRING" id="983965.A0A2T4BRH9"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="17">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB71922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="146" mass="15009" checksum="5C2EACB24960E180" modified="2018-07-18" version="1" fragment="single">AVSVLRGDSKVSGTVVFEQASEGAPTTITYDITGNDPNAKRGFHIHTFGDNTNGCTSAGPHFNPFGKNHGAPTDEVRHVGDLGNVDTDAQGNAKGTITDNLIQLIGPNSVIGRTVVIHAGTDDLGKGDTEESLKTGNAGPRPACGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRM7</accession>
    <name>A0A2T4BRM7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1385601</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB71972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRM7"/>
    <dbReference type="STRING" id="983965.A0A2T4BRM7"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB71972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="657" mass="70476" checksum="45BE8F5A4942754C" modified="2018-07-18" version="1">MLDAFEVLTTSGVVLWSRSYAPVSPSIVNNFIADTFIEEKTGSIAPTDSQSAATNPAYRSDQHTLKWTFVKELGLIFVVVYRSLLHLSWVDKLVDNIKTIFVELYGEQLTKPHTTLVECHSFGEYFDQQLQELDKSSTIGSKNPIDEQASSHSSAAGLTYRGRAINGGAAAAQDTTSADSTPVPTPNASRPSTPGVVVAKAGPVAKMSRRARKAQNSGSAPASSGDEALSSSRQKKGGKATKKGRKWNAEGFADEEDDDVQLDYSRPSLTSDSEAEAVGRSSALDAVDSSTWGSTSKGKFILKDLGDEVHDILASAQAQKSQKNARSETKTGLLGSGVSAISGLFRNVVGGKTLTKEDLDKAMKGMEDHLLRKNVAREAAVRLCEGVEKELIGVKTGNFESINAKIQSAMESSLTKMLTPTSSLDLLREIDSITSPPATSLRKARPYVISIVGVNGVGKSTNLSKICFFLLQNKYKVLIAAGDTFRSGAVEQLAVHVRNLKELTAREGGRVELYQKGYGKDAAAVAKDAVNHAAQEGYDVVLIDTAGRRHNDQRLMSSLEKFAKFAQPDKILMVGEALVGTDSVAQARNFNAAFGSDRALDGFIISKCDTVGDMVGTLVSLVHATNVPVVFVGVGQHYSDLRNFSVKWAVEKLLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSD8</accession>
    <name>A0A2T4BSD8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1363724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSD8"/>
    <dbReference type="STRING" id="983965.A0A2T4BSD8"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB72223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="234" mass="26466" checksum="FB2564A1E0B8E04C" modified="2018-07-18" version="1">MTSRDRRIMKELQDLTEDKDTSGIHAALEHEGSLSTLLGWFYGPPNTPYAGGKYVIRIQLPNEYPFKPPKMKFETRIWHPNVSSQTGVICLDTLNKNWSPVQTIKTALLSVRMLLENPNPTDPQDGEVASMLLNQPERFVEMAHEWAVRHAGAPRQANLDTSRYRSLANPTDGPVDASRYHGYRPELVEQFTSMGFSLDSVVEALEYCRVDHLLTSLPPARMSDVTTRLLGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSI8</accession>
    <name>A0A2T4BSI8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1394941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSI8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015443165" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11780" checksum="8186422FB1BEF480" modified="2018-07-18" version="1">MGHLQVVIWLAGVRWCCSLANSSRHTGLFVCLWLELVHCRQPLRWKSRRLNMLYLMQPVCSHGLMATIGRCKKAYPCKTLWAWAARPRCCLWKTFGLECTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSL3</accession>
    <name>A0A2T4BSL3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1342328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSL3"/>
    <dbReference type="STRING" id="983965.A0A2T4BSL3"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="104" mass="11567" checksum="75082B26599EB9A7" modified="2018-07-18" version="1">MANVKEVQRIIDNNNVVVFSKTWCPYCKATKQTLNDLKAQYEVVELDNRNDGDELQDALLEISGQRSVPNIFFGKKHIGGNSDLQALAKSGQLKARLEEVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT60</accession>
    <name>A0A2T4BT60_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_22424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT60"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="428" mass="47931" checksum="A1BAAE11E99636AC" modified="2018-07-18" version="1">MSRDWGVQGGATLCATRPSGPSGCTHLTSRHLSSIPAALTWDQHLRMEWCMYQLEPPRLELYRNSARDQPSTTPSRSERNKIRCRTGNKGKQDRGSRDAFLPQASSQKRRQVGQSSQEANSGQLLVERGDGRGMMEDDAASEHEMPTPQVPLRQWVPVMAAALLPLGIVEAELRSPAAVVAFSYPCPMGLAFSARLLGPRLVRVKPSEPSGERQMLGWPVVVPAHRGHRRPRGYGIIVCSQLAGGPVLQFGVEDFFPFFHSTLESRLRLEEAEDIGRVVSRSIWYHCHQTVNCQKGTTQTYTRTAGWQAKRPKSFALGKDLNFLIFAARRAVRWSRCFASPRRESIVGTISQRHRRDEGREEQEREFRSSPTMAPLSRGASCVALSRRVFGSLSLRLPKMRCTHPKAWAPSAEKLHAKSPKSHVLPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT62</accession>
    <name>A0A2T4BT62_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1394807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT62"/>
    <dbReference type="OrthoDB" id="5407417at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15144" checksum="EC55BB8F28019CBB" modified="2018-07-18" version="1">MATEPSNVVQVSIPLPRSLDTRVFIRVATQAKAILVSLTTASHEESSSLRPMGSFVYALPDRFNQQQAIATTLFSAEASLEFTTRVAKLVARKTQLPVYVTNSISLESMGMGGTVEEEMEAFKGVAEAVLSILPKKQVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTG9</accession>
    <name>A0A2T4BTG9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1405541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTG9"/>
    <dbReference type="STRING" id="983965.A0A2T4BTG9"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000027">
        <property type="entry name" value="Calmodulin (CaM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000100">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="142" mass="16267" checksum="7E387133AED39D2B" modified="2018-07-18" version="1">MADSLTEEQVSEFKEAFSLFITTKELGTVMRSLGQNPSESELQDMINEVDADNNGSIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTK0</accession>
    <name>A0A2T4BTK0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1362729</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTK0"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015479963" description="glucan endo-1,3-beta-D-glucosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB72643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="350" mass="38378" checksum="CBFD184E6F56E4F7" modified="2018-07-18" version="1">MISSLLSLAALAAVPALAAPATTAAAAAGNCFPMGNATLPGNFAAPSTPLDQWWCPQSDYYGFLGFSYPLEDGNCNAASNGYDQMNRDFAQMKKDFGASIVRMYYPVCTQSSVFINAIKAAYNNNMGLIVQVWTNFGGGNVWQQSQQAIYNAINDPSVAAIAPYVVHWAEFGSEPVGDGMDQGNFVNDLGKFRATLNQKGILVGISEDWDRPGTMSGSNGQGLASIGAGVKANSDVAHIHPMPFYHFNQPESQAWSYIQSQINWVKANVGLPTWVTETQWAWGPTSHYPGHTDLGRTQYSNYWKTFDNNCAYFKSQNVGWFLHAWRGEDTFDINDPNGGYIIPNWRPQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTW1</accession>
    <name>A0A2T4BTW1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1082043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTW1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="21301" checksum="A8629AAAD15FE6F9" modified="2018-07-18" version="1">MTSSSQIGKNPASRYLTGGREEIKIRIGVLGERQEKERKGVLVVGRGRRGCVNRRACGKFFFVGWVVEQSCSDAGEPWNLGYWEERCRGWLKGDGRERHCFFASCSLSFLDASIMVCGGLKGYEQMGNRLGVELRRSVWLDNALKTPRARFMHSVFRTATSSAQHERASLPCATLYMIPWSAQISPLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTY3</accession>
    <name>A0A2T4BTY3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative homoserine O-acetyl transferase, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1340845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTY3"/>
    <dbReference type="STRING" id="983965.A0A2T4BTY3"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="133"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="529" mass="57204" checksum="A27E510C43F84EFB" modified="2018-07-18" version="1">MRSHQALRLAARRPLLSSPSRPALARLTSASSSLSSLSSSSSTFSASRFSSSSSSSSSSPASASASSNPALAFPCLDAIESRSAPGPEPSYTSGATQTFHCNSPLLLDWGGLLPSFTIAYETWGRLNADASNAILLHTGLSASSHARSNTANPAPGWWEKFIGPGAPLDTDRYHVICTNVIGGCYGSTGPSSIDPANGETYATRFPILTLHDMVRAQFRLLDHLGIRRLYASVGSSMGGMQSLAAAAMFPDRVARVASVSGCARSHPYSIAMRHTQRQVLMMDPNWNRGFYYGRVPPHAGMKLAREIATVTYRSGPEWEQRFGRRRADPAKPPALCPDFLIETYLDHAGEKWCLTYDPNSLLYVSKAMDLFDLGHENQMATQARRVAREKALAANNYDAESSPQCNLTLPSEPYQEQPESSSSSSSQSTSLDNTADSLSAPPNPASYRPPEDLIKGLSPLRDIPTLVMGVASDILFPAWQQREIAEALRLGGNRSVTHVELSEETSLFGHDTFLLDLKNVGGNLRLFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU30</accession>
    <name>A0A2T4BU30_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1363099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU30"/>
    <dbReference type="STRING" id="983965.A0A2T4BU30"/>
    <dbReference type="OrthoDB" id="4900514at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015430855" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="560"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="673" mass="67422" checksum="CEC57796027510E6" modified="2018-07-18" version="1">MRLPAKVSALLPLLKVTDLEAPCAEGGVESADVGAPPRTNNQPQFLLQLDELRPKRITPSYLFPKGTCTECQFATFFSLKGDRLFADGELVAANDGTAYQPLLETPSSAAIDSGFSLEGGVLEWRHPSFTGGKASFCLSASDTVMAVFNESSIPTDCAPANLVNVPYDRCFPSTESINVLVLADDDIRPAPQTSGGVRETYSPVGADWPETKDATEHGYGRASIGTGQPSSPPPIYNYNYNNGGRGSTTPPSSDNYGANYNYNQGGRVATAPSSVGYGGENNYNKGGSATPPSSVGYGGNYHYDNGELDSPTNPSSVGYKGSHKHHDASSPGPAGPAGSDGWNGKDGKDGENGWNGKDGKDGDDGRDGGKGRDGDDGRDGDKGKDGDDGKDGDDGKDGDDGRDGRDGRDGRDGLQGPPGPPGPPGTPGMNGFNGLNGAAGPMGPEGPEGDAGPAGPEGATGPAGPAGADGLPGAPGPQGVAGPQGVAGPQGLPGTPGATGPQGIPGVAGPAGATGATGPAGPAGADGLPGAAGPAGPAGPAGPIGPPGPAGNGTAGFTGQYGYLGCYIANNDGNYGLTPYASQQVLTTSIDDCANICYATPTGPSLYFTLGTDTTTGDSICTCGDVLVAYNYPNTGLEFQCNTQCNFADNPTSEQYCGGLYSGIPTVSLFGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU69</accession>
    <name>A0A2T4BU69_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1340809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU69"/>
    <dbReference type="STRING" id="983965.A0A2T4BU69"/>
    <dbReference type="OrthoDB" id="5194044at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="448" mass="48173" checksum="EC01FF26727B7BED" modified="2018-07-18" version="1">MCLPCFPWTWTEYEDPLDSMPEQHVWVHDGQAWSLQRYSPKAPRRLRTGGEPLRQVHFQTPASGAGIKAATSAFPPAASSASPFTSTTANSTTNPPTTAAADPASASNGDSSSNQPDSFPQLGAPPYSTLGAGQWHTAADPTQSVKLPGQPFAGFAAPGAGPGPGASPFQLHPQLFAGPFSPLQQQHHHQISVQLQPHASLPTTAPITYIGSPIAMADYQNAAPMHTGVNFQPPVPDTTFGPIPHVYVPRFDGGYMPAAVQVGLPSVQFVSRPVTAAPMSTATYTVVTPKTYYYNGYTYYAIAQPSYVVAQQPAVVPQPFVGQQPVMIGGQPASAAIPVQQVHAVPPMGMPGAGGMPVYAGNGQIPDVFGLGKTPAEETVRQLQFAHANKLFEPQEFKPSDDDPSRFYYVREVDGNWTQRNRFTIDHLGDCRWYVTDEGWFYAVRMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUZ0</accession>
    <name>A0A2T4BUZ0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF866-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1340329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUZ0"/>
    <dbReference type="STRING" id="983965.A0A2T4BUZ0"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="18303" checksum="74D3ECBC8CC8456A" modified="2018-07-18" version="1">MFALTLTAELSGVTNLRPDDTQDNPFWYMFRVQCTSCRETHDNYVGVNRFETNEMSGSRGEANFVWRCKNCKRESSATIKSAPAAYEQAEPPNPQKLFEFDCRGLEFVEFKPEGDWLADGIDSGTKFTGIDLAEGEWFDYDEKAGEEVSIKELVWEIKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV56</accession>
    <name>A0A2T4BV56_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_142334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV56"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8789" checksum="8DC43D98B8B9EFE3" modified="2018-07-18" version="1">MCRSQAIRATYLRLRRIPSLDTASFLLLGEAYQACTSRGPVHRRRLCHHAGLRRIRCRRLGEQKKIRSLHHASGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVH1</accession>
    <name>A0A2T4BVH1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1382324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVH1"/>
    <dbReference type="STRING" id="983965.A0A2T4BVH1"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015724612" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="24071" checksum="F1486857BFB94226" modified="2018-07-18" version="1">MQWLCSLLLLASAASALKFDLVAHTGGESLKKERCIRNFVGSDTLVVVTSTVDGYKGDGMVVNIHVRDAIGNEYGRAKDVAGESRIVFTSHADAAFDVCFENLMVGPNKPAINLRTVELDIDIGADAKDWSAIQATEKLKPVEAELRRIEELTAEVVHEMEYLRQREQRLRDTNESTNNRVKWFGVGTTWLLVILWAWQIMYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVT4</accession>
    <name>A0A2T4BVT4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1404433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVT4"/>
    <dbReference type="STRING" id="983965.A0A2T4BVT4"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="434" mass="49118" checksum="66DA0A28AA27691E" modified="2018-07-18" version="1">MILGIFYARFFPQEGPKIVAQSPPGCITASSSSSSGNNNINSNNNATANSHNNSNTPLVDFDVLQEYIIPRQAFCNRFISINSPDGKYTILGFPVVIPHTKYMRNEFIFNFGLLVDADCDQAPFESVVRCLAETFAEMEKQNEYLSLSEAKGPEDDSMRRPIESLLEIVKEDLNNYGECMIPVDEANIINMKLFPHHATPPVVKGWHVPVARTKFPEIVDPTWDITLQKVVAKIDGVADVRRIAHEACVSLDLAKIAIRHLLYYDTILLLDIFFFSSCYAPRPGIHDFIRNVDGIVDECAGYVSHGRARVSNYLLIRFMASFSPGKSIKEWIMNHRDNGFELMSYIDIRRFVQFGVIKGCLYRVHKYVVSKQYLASLATGQSRPLAGGDPLQKYTDGCHHMDQIMTEQNLTNDQVMDRLKMLPIPRGDITVFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVW7</accession>
    <name>A0A2T4BVW7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1382567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVW7"/>
    <dbReference type="STRING" id="983965.A0A2T4BVW7"/>
    <dbReference type="OrthoDB" id="3548481at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="386" mass="42879" checksum="4B7AC0E3F4DF2A4C" modified="2018-07-18" version="1">MMCRFAPRRKGCIEIASRHVNIRLRSLRTMTNAINTHQTSAPTRSLQRCISYKVETRRHCVLWGSRLLGSLTSHKFCTQTTIQSEAPSPKDNSEPTRVRLGSHGTKDDRDKALLQEAIGYADSLKANRGEDGFLEEKNNLSLTPELGFCGRVYIAPKYRAIDRAKTIVKENSDYHHFIFFVDGSLLPRTDAVSGSVVTCTGTAVVYKPLEPNQPWVERVFVPSKCERGSDWIEVIALLNGLKVAAVETDLFRRCDPGDSDDTVARLKATIFSDCTSALQLLVKLQSKTVAKSRLLEDPVVRELIAMSQYLHRRGVAVELRWVPGHSQIEGNTYANGAAQYAARHPEIGAILEERLQVTVEVPPNTAESHASPQNSSQKNKPEAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW03</accession>
    <name>A0A2T4BW03_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1424788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW03"/>
    <dbReference type="STRING" id="983965.A0A2T4BW03"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="72"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="507" mass="58436" checksum="1B24C61D6B91D032" modified="2018-07-18" version="1">MLQQNILNTSRDWEEIKPEYDPESIKESKGYAIWKAIPYTPKHKRYIGRLVNALSKIPVAFTAAEKLRPTSYLDGLRGFAAFLVYWHHHELWVHGWTKQNSIFENGFGYDGKYYMAAFPGIRNFFTGGHYAVSTFFIISGYVLSLKPMSLVQAGELAKLGDNLASAFFRRWPRLYIPIIVVVFTYITLWHMAGMWINGMNRAESWSDEVVSLYREFKNFSFVFKEGGVPWLSYNFHLWSIPVEFKGSMVVYASQLALSRSSKAARLSCEAFLVFYFMFIADGWYCAMFCTGMLLCDLDLLANKGELPVFLACLEPAKDFIYYHLLAFSLFLGGIPSENTEVQHLQKSRGWYYLSLLKPQAVFDYKWFYLWLAATFLVASIPRITWLKRFFETKFCQYLGRISFALYMVHGPVLWTLGDRLYAAVGWHTDEHLQHMPHWVDKLPLPKSGPLGLEVSFLVPHLVLLPLTLALAEAVTRWVDTPSVRFCSWLYHKTLGGSDPVLAKQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW34</accession>
    <name>A0A2T4BW34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_133349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW34"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="276" mass="29733" checksum="DD727365DA554D78" modified="2018-07-18" version="1">MAVPSFVLLGPPALIPTLASNMHPHTGDDQLRRGQIIRSRAVLPSASLAVSSSHLFIQALPSLSDPVLRAPCFALHAPCLLVSLEKFRPLTDGRSLRTTLRHLSQNHPLQIPSTHCLLVLRPQRASSFLVEARRFSPDTSSLSAPPPLSPMSRETTETSPVPQGPLLAHSTPCGQPSLDRPSGVCRMQHPCNQTCAQGRLAGSRLSGAAISEEQLSDPFFPSLSSLSSFPSAVGRKQETGETVGFRRALPWVCGIRTPDAWRHLANCLNVTGACRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW67</accession>
    <name>A0A2T4BW67_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="11" type="ORF">M440DRAFT_1433069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW67"/>
    <dbReference type="STRING" id="983965.A0A2T4BW67"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="121"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="394" mass="43817" checksum="AFDBBEAFF5D7B243" modified="2018-07-18" version="1">MSNLKRKAASIGNEAEAKKPKANGSIASFFGAVPKPAGASPASAPSPAAKFDKAKWVESLTAEQRELLQLEIETLHDSWLALLKDDVTSKEFLELKKFLNRETAAGRKWFPPKEDVYSWSRHTPFNEVKVVILGQDPYHNVNQAHGMAFSVRPPTPAPPSLRNMYIALKKDYPSFIEPANRGGLLIPWADRGVLMLNTCLTVRAHEANSHANRGWERFTQKVIDLVAQKRTRGVVFMAWGTPASKRVQKIDKQRHLVLLSVHPSPLSASRGFFDCGHFRLANEWLISRYGDEGEIDWALRPGNTTKKVIKEALKEVVNEEKAATASGVVREAKGSDKTEEEERKETSTETAKGTANGEIKTKKPEPNSDEDDVDSDEEAALEEALKLAEEQIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWP1</accession>
    <name>A0A2T4BWP1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenocysteine lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1440687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWP1"/>
    <dbReference type="SMR" id="A0A2T4BWP1"/>
    <dbReference type="STRING" id="983965.A0A2T4BWP1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="77"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="468" mass="52194" checksum="2A927D4CF1FCAC20" modified="2018-07-18" version="1">MASLPVRQREEGEAKVGEDGFKVFGGEMTKDFLFAPNWTNLNHGSYGSIPRAIQAKLRSYQDDIEARPDPFVRFEHARLTDESRAAVAGVLNAPVETVVFVNNATEGVNTVFRNIKWDADGKDVALYFTTVYEACGKAIDFLYDYHGEGRLSSREIEIAYPIEDDEILRRFRAAVEQVRSEGKRAKICIFDVVSSRPGVVFPWERMVAACRELGVLSLVDGAQGIGMVRLDLGAADPDFFVSNCHKWLFAPRGCAVFYVPVRNQGLLPSTLATSHGYASLTGKRRVVLPPHVGDGGAGKSAFVSNFEFTGTRDYAPNYCVKDAVAYRRDVLGGEERILGYLWELNKKGSRLVAERLGTEVLENKKGTLTNCAMSNIAMPLWKGEKEGKEGDDVVVPEEDGDRVVAWMMSTMARDYDTIVPMFWLGRRFWVRIAAQVYLDLGDYEYGAEVLKKLVERVGKGEYKSGQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWW3</accession>
    <name>A0A2T4BWW3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1360549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWW3"/>
    <dbReference type="STRING" id="983965.A0A2T4BWW3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33227" checksum="5D498ED6EA3A79C0" modified="2018-07-18" version="1">MGPPPGERHLCHCGRGFLRKEHLRRHQAVHGSPSFTCHVCSRSFSRSDLLRRHLTLHDASAPSDSKRVRACDACHASKIRCDGGARCSLCKKRGINCAFTRAPGPSLASDIRQGTASSSLHSSRGSRSPDGPRSSTGTSVSSSGSRSGMNQVVLPMSFINSTVVRQEPLPQQDPSSASLEGLQLVLEAVSRPKSTSSSRPQRQPPPEVKNWSAACIDAYFGRFHDRWPVLHAPTFEKEVQSARLRSTVLLIGSWLRHENEGNNHLIFDIHSLLVKRLLDEMVRLMCSRVRGIRGADLLVFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX60</accession>
    <name>A0A2T4BX60_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_121991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX60"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="128" mass="14140" checksum="0554AD8486BA535B" modified="2018-07-18" version="1">MLKPLARSRASLFPLSVFEARQSSSSSLGGAGVGDGTAARAIGPPIVRLKAVLKRFPVRNLDIGSDDSQAHGPHRREIRRQGSQEWRRNRKLAAKRSGEMPGHGCCMVERKDARDDSTMASEWLMIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXB5</accession>
    <name>A0A2T4BXB5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_57875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXB5"/>
    <dbReference type="STRING" id="983965.A0A2T4BXB5"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF194">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="362"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="468" mass="51929" checksum="1BF59A70D4F71E18" modified="2018-07-18" version="1">MPIKSLYQPLDIPQTNVLTYLFGNGATLSHEPIWFDAKDPSRSLSPHQLVQWIRRLGLGLQRLGLRRGDVVMICTPNHIFVPAAYLGITGSGCIFSGANPVFTVAELSYQLANTEAKAVLAHPSVLSKIVEAAAKANIPKARIFQFSDSPAVLPPQDGVLDWKAMLPPYEEAYDWQWPSLTPAEARQTVATINFSSGTTGLPKGVCVPHASLIANVEQSIHLRHAHRKPSWDQLPRNRWIGLLPLYHAYGQLYACLMAAKTLTPIYVLPKFQYEDFLQAIQRFGITQLQVAPPIVVMLAKRPETARYDLSSVRHAATRECLDEEGWFRTGDIAVVNSEGLFSIVDRKKELIKVNGLQVAPAELEAVLLENEHIADAAVVDIKFGEDEWPRAYVVLQPAAKGKVSPKDIQDWTAARVAKHKRLVGGVAFIDEVPKLASGKIVRKVVRQWSRRDAEEMLKNGTAPVRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXD7</accession>
    <name>A0A2T4BXD7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1464665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXD7"/>
    <dbReference type="OrthoDB" id="4897479at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="303" mass="34546" checksum="45FB417BD859A9FA" modified="2018-07-18" version="1">MSFRVQTREIPTFSGLPKEIRMLIWEHVISPSVHRISAISPMPTMRVRASDTLARSTAPARAALAVSREERAIILEWLLPNEMPVLGGGNKSGVLRFHASRDIICFVWEVLRRQFISLSIKWWQAGRFREGVADQRPAWISQVQNMAMELAPTETGWHADPPTHLVFASFGLGNHCSWFRGLKRLYIVCEPREGPLWSRFIERLNPDGSVSVKLAKGCEVRLNKEHVREAFLHAGTYSGRDEVQVYLSGEAAIERLQRRRSACTAVREVFGLNKRRREQELRGSPDDGLKYDVKASVLLHVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXP3</accession>
    <name>A0A2T4BXP3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1424549</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXP3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXP3"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015506008" description="Probable aspartic-type endopeptidase OPSB" evidence="12">
        <location>
            <begin position="20"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="54"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB73996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="488" mass="51016" checksum="302BF26AF6E736F5" modified="2018-07-18" version="1">MRASPLAVAGVALASAAQAQVVQFDIERRHAPRLSRRDGTLDGTLSNQRIQGGYFINVQVGSPGQNITLQLDTGSSDVWVPSSTSAICTQVSQRNPGCQFGSFNPDDSDTFDEVGRGLFDITYVDGSSSKGDYFQDNFQINGVTVKNLTMGLGLSSSIPNGLIGVGYMNDEASVSTTRSTYPNLPVVLQQEKLINSVAFSLWLNDLDASTGSILFGGIDTEKYHGDLTSVDIISPNGGKTFTEFAVNLYSVQATSPSGTDTLSTSEDTLIAVLDSGTTLTYLPQDMAEEAWNEVGAEFNNELGLAVVPCSVGNINGFFSFTFAGADGPTINVTLSELVLDLFSGGPAPKFSSGPNKGQSICEFGIQNTTGAPFLLGDTFLRSAFVVYDLVNNQIAIAPTNFNSTKTNVVAFASSGAPIPSATAAPNQSRTGHSSSTHSGMSAASGFHDGDDENAGSLTSVFSGPGVAVVGMTLCYTLLGSAMFGIGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXX8</accession>
    <name>A0A2T4BXX8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1337567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXX8"/>
    <dbReference type="STRING" id="983965.A0A2T4BXX8"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="418" mass="45868" checksum="E645BC31D172EF79" modified="2018-07-18" version="1">MQNLRIAIIGAGPAGCMLARLLHLGGIQATIFEGEASANVRSQGGTLDLHTNSGLAAVKAAGLWDVFLSHARYDGQYMAIVDKNLRYYIVRGADAESSAAFGERPEIDRVKLREILLDSLPQGTVQWGHRLQKVDGTTLTFTDGTTAEFDLVVGADGAFSKVRLSIAPELKPEFTRVGMHDLSIPDAEKTAPEIYKIVNRGSVFASADGQRFTLQQMGDDSISMGFSFVRDDPDWMRPEKCGYDAQDLAQVKKALTKELEHWGPEFRKALDAAQGRTSTRSLFRLPVGRKWEHKPGVTLIGDAAHLMTPHAGEGVNQALEDAMILARVILNAQSAEELDDGIRQFESDMMARVEKIQQLAWDRCQALMFSPGVPQSVVEKMAKQRKMQMAGRLDEEQAKAVDEAIAKAQAEANAMNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY59</accession>
    <name>A0A2T4BY59_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1359796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY59"/>
    <dbReference type="STRING" id="983965.A0A2T4BY59"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="239" mass="25684" checksum="8EBF01966E2F3A5B" modified="2018-07-18" version="1">MAAPSAKKRLVHHLDTPFSTSSWPVISLDDQDAILELLCHLLSPIGQHRRLHIKPSKGKRAARREKKTKMKLDEPSDSIKIEPPPVPELSASVDIGFNSITNNLGSLAQPSDSTARPGKGYSMVFVARGSQSPAFNHHFPQMVAAASRNLPDKEKIRLVGFSKPCSERLGSALGIPRVSSVAVSPHAPGADALFALVQSTVSPVESPWLDEAACATYKPTVIGSVETTVGTKRVKAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYA9</accession>
    <name>A0A2T4BYA9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1359889</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYA9"/>
    <dbReference type="STRING" id="983965.A0A2T4BYA9"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
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        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="250"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="566"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB74255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="761" mass="82436" checksum="224EE9248FD15962" modified="2018-07-18" version="1">MSSSSGIIDHSPHQPDPSPPVATASNLVLIDNYDSFTWNIYQYLVLEGATVHVFRNDKITVEELIKHNPTQLIISPGPGHPQTDSGVSRDAIRHFAGKIPVLGVCMGLQCIFDIYGGDVSSAGEWLHGKTSPLTHDAKGVFAGLPQGLPVTRYHSLAGTHLTLPECLEVSSWIAKPDGSAGIIQGVRHKKYVVEGVQFHPESILTAEGRVMIRNFLHMQGGTWEENERLQKAASKATSSSAPKPQKNNILQTIYANRKAAVAKQKEIPSQRMSDLQAAYDLNGAPPLVPFVNRLKQSPFDVALMAEIKRGSPSKGVFALEVQAPVQARKYALAGASVISVLTEPEWFKGSIEDLRAVRQVLDGMPNRPAILRKEFIFEEYQILEARLAGADTVLLIVKMLEVELLERLYKYSLSLGMEPLVEVQNADEMTTAVKLGAKVIGVNNRNLETFEVDINTTGRLRSMVSDSTIICALSGINKHQDVLDCKRDGINAVLVGEAIMKAPDATTFISELCSGSKPPPKNNTPEKLHVKICGIRSVEAALEAVEAGADFIGVNLVPGARRAASHEVALAISDAVHSYTKPSGTPTTLAIPSSAATDFFELTTRNLKTPRTQVVGIFQNQPLSEVLEKQRLYNLDIVQLHGEEPIEWAKAIPVPVIRCFKPNHPAVRLRGYHVVPLLDSGAGSGKLLDVSSVKELLQKDPELRIFLAGGLNPDNVAEAVNALGEFSSQVVGVDVSSGVEEDGKQSLAKITAFVKAGKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYL5</accession>
    <name>A0A2T4BYL5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1440568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYL5"/>
    <dbReference type="STRING" id="983965.A0A2T4BYL5"/>
    <dbReference type="OrthoDB" id="4838114at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="265" mass="28436" checksum="DC285A1272415622" modified="2018-07-18" version="1">MSSSTQTQTVLPNAPALPPRSALRASRLLATMPQKLSEHRPVLTPAAPHLLYLSSEEDVSSSADDFSDCDYSSDSEHAQEAPEQTSKCHDTARMVSVVFSGKPCIVQLSRRSISPSSSADCPVGKLTRTATEPIIMSRKGSTSSTSSAKLVSQHPPRSSSIMSPVASPSFLNMDPFAAKAEPEEPEPQLRKTAQMFKRTLSLVRKRSRPSLNAAASRSREARRGQGGEPHQHSPERLVTTATDVSGDDGSEESQQLLGRDDAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYP6</accession>
    <name>A0A2T4BYP6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1403819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYP6"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015560945" evidence="8">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB74451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="139" mass="14761" checksum="D2C9A64EF6B89B47" modified="2018-07-18" version="1">MGACAVVLLVILTIIFPPLGVACVAGCGVDVLINICLTILGYFPGHIHAFYIEYVYFDRRQQAREGNYPPRRAPGIYSEKVQAGGRGPRPGYGTMAPPVAPVAPVEPVGGPAYDSQAYGTQRYGNQGYSAQGHGNQGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZ02</accession>
    <name>A0A2T4BZ02_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1028712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZ02"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="293" mass="32863" checksum="D3C04C0E7B5D2A51" modified="2018-07-18" version="1">MLPLRLCSQRPLGTFINPSSPLRLINLQHLTRTRHPRHIESRCLQRCYAQASKKPISRPNASAAEQAKQQAKAAADNVGSKRYEIAERLLIYHAGTGRITFLAMVKVTTLFLGAFFTFIVVPGYVKAEKSKWEIMGVALCGLIPLFFVAYTTSPFTTQIYIHLPPAARTSRPALERFIHGALPPSTELTLTTMSAIAKPRYSTMQLGHLRPAKRRFGIVNYVRDAEGAIAENETRKWYNLRALTKFGVQEVRTDLKKKKKAKGTKIRDLTEAWIWDAVKDKIAKRAVAAATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZA2</accession>
    <name>A0A2T4BZA2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1336940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZA2"/>
    <dbReference type="STRING" id="983965.A0A2T4BZA2"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="224" mass="24668" checksum="07EE38E36DA3E3C5" modified="2018-07-18" version="1">MWGWFGGGAAAQKKKESAKNAILGLRSQLDMLQKRERHIQNQIEEQEAVARKNVNTNKTVAKAALRRKKMAEGTLDKTIAQIATLEQQINAIESANINRETLAVMEKSSQAIQSIHQGLTPEKVEEIMDKISEQNALSDEIVNAITSNTIGEQVDDAALDAELAELQQEQLDEQMLSAGNVPVADAVHKMPSPSRAEPISSKKVAIEEDDEEAELRKLQAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZX5</accession>
    <name>A0A2T4BZX5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1423775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZX5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="169" mass="18247" checksum="DEA6C4383AF243B8" modified="2018-07-18" version="1">MATPPQSAQRPLESSPSSDLLLVTPITPIVGDESKLLDPILQASPLISSATPREDAADQIAISPSGKRPAKHVESLGRKRQRTHLVRSEDLDGDYKPGSCDDSDESDVRDAPALDDEPEVILDVMDLDDTPTPSKPSNLESTLKASELRIFPAAILIGQRLYTPYAEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C065</accession>
    <name>A0A2T4C065_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1336996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C065"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="302" mass="32175" checksum="EA58487CB9861FB1" modified="2018-07-18" version="1">MPVQVAVAGATGAVGIPVIAELLKAGYLVTALSRSAGNCSSKLPKHPNLSIAEVDYDSVASLTAALQGHAVVIAALPVDTPIGSQDTLIDAAVAAGVTRFLPSEFGTDTDKDKCMKLPVFANKMHALAYLKDKVAKHPGFSYTALCTGAFLDWGLAAGFLVHPKSHTATIYDDGNLPWSTTTLFTISTAVVSIIGRLEETKNRHVYIQDAVVTQNKLIELAKKIDGRDWQLTYVDSAVVCAEAHLEYQKPDADIAKGLMPLLHISVLGKGYGGDFSGHLDNELLSIKEMSDEELEGVIAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0P3</accession>
    <name>A0A2T4C0P3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1431691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0P3"/>
    <dbReference type="STRING" id="983965.A0A2T4C0P3"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="46"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="314" mass="34277" checksum="C9D840C5B8578A9C" modified="2018-07-18" version="1">MGLLSSFASTKNVQVYALATGWAHLPDKWIWQDGDDDIVKARQRLPAYSFLVRHPSGKNILFDAGLPKNLDVIPPATRSINHIFEPYVPKDARDLLAEGPVPPDSLSAIILSHIHFDHVGDPSLFPDVPYIAGPGTKAAALPGYPVDPNSPVLSSLLTRDNYTELSRTEDAWTSLGPFPHAHDFFGDGSFYIVDTPGHLPGHITGLAQTGPDEWVLMGGDCCHARSVLDGSRPLSLDGCPGGTSMHVDVDEAITSIERLRKLDQDDTVFVALAHDATLEGKMPEYPTALNGWRESAWWASMKSEREKTRVRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C145</accession>
    <name>A0A2T4C145_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_340446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C145"/>
    <dbReference type="STRING" id="983965.A0A2T4C145"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="273" mass="30587" checksum="94538A3523198EA9" modified="2018-07-18" version="1">MAGFMNSPSLRGAGLVVLQALRVATVITLLTSGAACWILVINVEKHKPYFIFECFTLFFVSVLCSLLVVSELAFAQFIKIYLRRMWPVLSDHHGLSWLGLGMIIIGCNILGMLNHDLKMASALSSLVLAAGILALIFGFLNIVCSFIWCDRKEGITSRDIRANGSLARSQREFSDYDPPSRSSSSRNEKTRSKFVSMFWKKDKEEDYMNGQPEIAAPPYINISHHARDLEAQSDSPIIPGLKRPDTALHPMNTRMNSRSSRSSRYSEANMSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1P3</accession>
    <name>A0A2T4C1P3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyruvate/2-oxoglutarate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1402021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1P3"/>
    <dbReference type="STRING" id="983965.A0A2T4C1P3"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF2">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="5"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="366"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="481" mass="52247" checksum="37FCC84B90124D20" modified="2018-07-18" version="1">MSIHYDAIVIGSGQGGTPLSMAFANAQHKTALIESSHVGGCCINEGCTPTKTMVASGRIAHLTRRGPQYGIYAGNQLDAAQNQIKVEMEVVRQRKRDIVDKFRSGSERRIREAGVDLIFGTAYFEDERTVHVRTTDGPEMSLTTDRVFICSGERPAIPKIDGFDATAFSPGTILDSTSIQELGVVPSHLVVVGGGYIGLEFGQLFRRLGSAVTVIQRGVQLLPREDADIAEAMLGVLKDDGVRVLLNTTPTAIRPAGNEDPATTVAVTIAASGRDCQIELQASHVLFAAGRVPNTEMLNLAAASIETTARGHIITDAQLRTTNHRVWALGDVKGGPAFTHVSYDDFRLLRTNLLEQGNVTVSGRLVPYVVYTDPQLGHVGLHEHEARRKYPDRTLQVASMPMAYVARALETDETRGMMKAIVDTESQRILGFTCLGIEGGEIMSIVEMAIIGGVKWTTLRDAIWAHPSLAESLNNLWSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1S4</accession>
    <name>A0A2T4C1S4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HET-s/LopB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1256384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1S4"/>
    <dbReference type="STRING" id="983965.A0A2T4C1S4"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1180" mass="129617" checksum="64585D3F6EE79452" modified="2018-07-18" version="1">MDSILPMGGFQLPFQRRLSRLYNDTKKSGDFVKEPAQHEDDPEIKALYRKLRIQKDRFVSWGLEWSDPNQSAEIDESLSKAGLSEVVGSIMSTIKDILAEAEPLWMSYKRVVEGVRPSPDRKAPLVQWDKTRFEDLIRDLTASIDTLYDLSRMRSTEVSNPQVTKSAIKTAASEGEFRPFESTRMQTPQQIDPKSLTHLQPLEDGLSTISASCRHVVYMSKTAYSELTTQGLTRQPWAPLLLEYANFDPIYSTTGIMPPMTRFEKLSAALQQNPQRAPGAWTGLPRLLGYFEDLENSRLGLVYLFPPSFNTLASNRVSQNPQYSLPTLSDLLARGGSEPPLEAKFRFAYNLTNTVFDLHARGITHGNLCDANISFSRAAAADHGGKDAQVDVRRPVLSSFDVFTEEDSTECSIWRHPLDPRAAQTSPLPKSTDKRVLEVYSLAMVLLSIGLWTKLESLAPAAAPTTVPEGVLDTLAIRCGTLYMKAVQACWKVVDEELSGSPKGESLLSAVQMRVTRFLEACCILDGVSGFEERLGQEPSPVEPAPLSTAGPSKDGKAKKALPGPVAPAAPAKKPLPPSAPAHIPASANETNEPEAKESKSEAKVRLYPHVPLPPDVVEKWNAILMPQINIALKSFYRKHPESVEISLESVGPSPHQTRPTVLVVCTSVGKVRAILKKKLSELFDDSTGFGLKVCRGSVIRSRRQAGAVKRSMARGSRSGGNAGHDGDDDHVEAVNPEYQERPHNGASIGAWIGDRHLPPVSFGGLVIVDDKTYGMTVHHMLDDPDRDFGVPDTMRSSAIPGREWLPESSSGSFDGEDFSYELSDTESEPYSETDLTSDFEDEEDDEEDEEYNEPGDIPGIEPGCGDGYIVTQPALDDVEEGFYPCAETEDEDHLDTYSLGEVYASSGIRRKQANGLLHEVDWALFEFTDGRLPDDNYIPRISDLGQQSRKSSKSSQPPLRPTTVAPWAALPGLEVQCVARTSGQQTGQILPALTSVKIYGRQSPSHTYQIASTPPPATGSTAKGSSIPLGIPGDSGAWIVDRYQGQLCGHVLAWSQRKHVAYMCPMDVLLLDIAQTLEATEVRLPGGEPVVMLNTEELDSTREVEEEDDWEAEEEEEEEREEEEYDMPPALAGEPSSPKRIPTPATSSSPIIMDVAEMPGLTSKMESMKVGTRRINVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1X4</accession>
    <name>A0A2T4C1X4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1392114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1X4"/>
    <dbReference type="STRING" id="983965.A0A2T4C1X4"/>
    <dbReference type="OrthoDB" id="5304883at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF32">
        <property type="entry name" value="PROTEIN KINASE COMPLEX COMPONENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="272" mass="30437" checksum="C239AFC22D640ED7" modified="2018-07-18" version="1">MSSSAATETQQVEATAAIQKQRQQQQQQLQEKQQKHAHRSGPSVGRTSKLQAYSASMSAQLIAQQDAYAQSIDGVRLKHDALRRANPSSSAPNLHPPEPYIVVGADSQPLNLQHGAITRKFYSKNEPPISVNQYLQRLHQFCPMSTAVYLAASLYIHRLAVEERAIPVTRRNAHRLVLAGLRVAMKALEDLSYPHTKIAKVGGVSEVELARLEISFCFLAGFELVVSAERLKNHWAVLREGKIQRLVDGIEVPLLKLDRKKKMSRDVHQLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C200</accession>
    <name>A0A2T4C200_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1318098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C200"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB75583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="143" mass="16126" checksum="4630410AD0CD08CC" modified="2018-07-18" version="1" fragment="single">AAPIEHSYWPIVRRYIENGGHAKHTRRIKAVCPICSDELTIYGIDPAKDELIDQAFYSIDDEMPAFNRCTTISCGHLFCSDCLARAFEADREMRRRTACPVCRFDVDCRRCGGSGRVVNLPVTGIAARWAGFPRTMDEGGRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C279</accession>
    <name>A0A2T4C279_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0052-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1334905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C279"/>
    <dbReference type="STRING" id="983965.A0A2T4C279"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="506" mass="54019" checksum="8D9800B6985C9793" modified="2018-07-18" version="1">MAQILVQDSLQPPQPAVGPGPRPPLSRIPSSPGPGSGSGSARTGIVVFSGGSAANSLVDVFEGVRRASAATLSYVIPISDNGGSTSEIIRVFGGPGIGDVRSRLVRLIPADNKPETAAIKHLLNHRLPPSYAAARAEWFDIVEGTHPLWRDVPSPKRELVRSFFNSFNLEVVKRMRPTSRFDYSGSSIGNLFLTGARLFTGSFEAAICLLSSICAVPDRVAVLPALNTNFAHHIAAGLVDGTVITGQNDISHPSAPTAAVPLPGVGSSGTHTPALSLNHDLDEGHDDEDIEDANLPGSLPALRRPAIAISKQDEEDLPCRIDRIWYINPYGQEMRLPANPRVLDALRGAHTVVYSIGSLFTSLVPSLVLKGVGEAVASPLIRNKILLLNGTIDRETGPSSDPFSGLDFVATIANACADSRGLPRPSRVEYAQYVTHVIYIEGPTSPVVDRRLFAELGIDTTRLYGPKDGQGKGGRYDAKALEQTLESIIGRKDTRPDKLRRNTLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2C0</accession>
    <name>A0A2T4C2C0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_55323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2C0"/>
    <dbReference type="STRING" id="983965.A0A2T4C2C0"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="333" mass="38386" checksum="355866FB8BE60916" modified="2018-07-18" version="1" fragment="single">RIELRVLKTLKANDEENRNRCIHLRDCFDYRGHICIVMDLLGQSVFDFLKGNGFVPFPNSQIQNFARQLFTSVAFLHDLNLIHTDLKPENILLCDNSYQTFTYNRKIPSSSTTINRNASQRRVLLDTEIRLIDFGSATFQDEYHSSVVSTRHYRAPEIILGLGWSFPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMEAVVGSRIDSHLVSAVNKMSTRSGGNPASKYFKRLKLDYPTPETTRGSRRFVKAMKHLSDIIPSNTTFFKNFLDLLRKIFVYDPAHRITAKQALNHPWFKEMAPPDDGTEAAKIRFERRRLEIDKAKQHGHYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2I7</accession>
    <name>A0A2T4C2I7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1402261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2I7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2I7"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="207" mass="22079" checksum="61A82A8C6DF7933C" modified="2018-07-18" version="1">MTTPTRTSPPSWRTTSKLAAGGSLGGSSALSQLQPTQVRTLRDGFQILDRDCDGVVNREDVADMLGQLGLPSGSSDIGRFFPPSKPQTMTLAAFLNSLAESLAVLSPSTELLSAFSAFDEDDSGQIDWAELRDALLNTPPEAGQSALSAAEVDKVVEGFTGRRAFNRNMNAHLSARRGEVFKYQEFVHSIMGSNGGSEGGSHERADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Q8</accession>
    <name>A0A2T4C2Q8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1402325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Q8"/>
    <dbReference type="STRING" id="983965.A0A2T4C2Q8"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13932" checksum="205DD8C90385D094" modified="2018-07-18" version="1">MTRRLVPPANYTTPPFPSLNVHSLFDATPEKQFTLYFIGDVWRFTVIWTLITFALFHLGAVFIAMFTHGWKKSSWKYLWITPIVYLVVAGIEALVSGTIVGVMSVLMSLLSIAAVVWYTKGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2R2</accession>
    <name>A0A2T4C2R2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_5338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2R2"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="84"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="182" mass="20079" checksum="FFD38537A94C1642" modified="2018-07-18" version="1">MSAPFQTAAYAMPMAVPSKGNNQHPAYSQYSSSPPECDDTMSSASGVPSGYSATSAGYIGSSSGDYESTGSASGVDFQEYMQERFSNSFDPIPLDRSMAVQAQTSGKLNAKHRELLELQKQAQARLARTRERFSEGMRDAREVRNDLEWTQKKVSSLNAKAARKHPKEHAKARQRFPSPEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2Y2</accession>
    <name>A0A2T4C2Y2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1335060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2Y2"/>
    <dbReference type="STRING" id="983965.A0A2T4C2Y2"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="98"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB75920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="477" mass="52115" checksum="B67EAFCEAE9D17DD" modified="2018-07-18" version="1">MADSDGEFVADMSDDDIMDHTVTDGDPSAARPRGSNKPAKRKRDRNGGSKAWEQSRRTWETDLPEESDGMLNLAGYEAERRRRLLRDTTPLQRGIIRHLVLVLDMSFAMAEKDLLPTRYRLALGYAAAFVREYFEQNPISQLAIVGMRDGVALRVSDMGGNPAEHLERLREFEGQDPSGNPSLQNALEMCRGALFHAPSHGTREVLIIYGALLSSDPGDIHDTINNLVAERIRVSVVGLSAQVAICAELCSRTNVGDDSQYNVAMDETHFKELFLALTTPPVNRTKEQSTSSLLMMGFPSRTLAPGGTTSYCACHSQPCREGYLCTRCGVKVCRLPSECPACGLTLILSTHLARSYHHLFPLRNWVEVPWSEAARSTACFSCQSPFPEPPKANREKAKDEAPTKAPAKGVSESGRYKCQVCDNHFCIDCDVFAHMVIHNCPGCQSQPAAAAAPPMTDGVEANGNGHTNGGGMMAIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C385</accession>
    <name>A0A2T4C385_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_53534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C385"/>
    <dbReference type="STRING" id="983965.A0A2T4C385"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="117"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="351" mass="38148" checksum="7CC589C92CC73218" modified="2018-07-18" version="1">MSSELQLAPRVLAVASHTLSSNVGNKVAVFVLQSLGFDVAALNTVQFSNHTGYRQWTGTRATAQEIANLYAGLKQSYLDDFDMMLSGYIPGAEGVTAVGGIARGLKDKFRDVPGKFFWVLDPVMGDNGKLYVAPEVVPAYKALLPYADLILPNQFEAEQLSDVKIVDMASLTQAIQVLHEKFHIPHIIITSVSFTTPDHPPSHLSVIGSTMTSDRRARTFKITFPSIDCYFCGTGDMFGALITSRVREAVEAVPGLAGRESWLSDDDVPATDLPLARAAEKVLASMHEVLARTRDAMPAVVERTWASMGAEADRGDEDKAHYVKSKAAELQLVTNLDSLRSPTTTFSAVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3Y2</accession>
    <name>A0A2T4C3Y2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1249228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3Y2"/>
    <dbReference type="OrthoDB" id="5398515at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="426" mass="46132" checksum="EEB47DC4FD0D1416" modified="2018-07-18" version="1">MAAVDAAPSTPSPPSSSIRTPPAPRLGFHDSWEPYSPRKSARLSAQRASARTPSPPPATTRQALASPRTAAKSSAQSSAAMTSPASSPRKKRQPAADSVRRVTATLTAEAAVASGSKEKTVAGRAVASSSLPLPTPSKTPQKPPSSKDVAQLQAFARNLFPVAEEAELSSPRKKRSKKYSSVTLETFRAEVAAEDIEIFTDSQDRIPKKDDSKSNPFIGNATSAEPSKRRTKRKIHVPGEGSQSVDEVSRREDGMIYVFRGKKFFRKFSEFDDGEEDEELPSDVEAHFAKPLTRSSIKPRLLFPAKTPAPKTKAMLEEEEAATDVEDVAEPEPEKPSAVVETPVEAKQERAKTPDAPKFAPVSPPETRRTTRSTNKLAAETAPIKRTGKKSPFDSWIRTKEHANRSGTKRAAAEPLAPAHAKRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4M6</accession>
    <name>A0A2T4C4M6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-dependent oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1401952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4M6"/>
    <dbReference type="STRING" id="983965.A0A2T4C4M6"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="359" mass="38757" checksum="5F02A076CC85E6B6" modified="2018-07-18" version="1">MTDIIVVAGAGVSGLTSALLLSKNKDNVITVVAKHMPGDYDIEYASPWAGANVLPMATDENSRWERRTWPELKRLTEDVPEAGIHFQKARVFRRTKDESAPGIHTADPLFSANPWYQSVLPDYRELGPNEVIPGHDSGCEFTSLCINTAIYLPWLVGQCLKNGVIFKRAVLTDIRDAKGLSHTGQPAKVIVNATALGSRKLGGVKDEAMVPARGQVVVVRNEYHPMIATSGTDDGETEMTYIMTRAAGGGTVLGGTYDVGNWESVPDPNVAVRIMKRAVDVAPGLTGGKGIEGLSVIRHGVGLRPYRRDGVRLEAEALEGEDGERVVVVHNYGHAGWGYQGSYGCAERVVELVEGVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5C0</accession>
    <name>A0A2T4C5C0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1332010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5C0"/>
    <dbReference type="STRING" id="983965.A0A2T4C5C0"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="824"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114406" checksum="744A7D012E2153EF" modified="2018-07-18" version="1">MMNGGGRGGRLRSRERGAAGRPITRTQVQDFKKPDLPPLKGAPSGRRQYAYGAAEEPSNLRRPSLDGMPITLQEAMDGVLRRQEAQEAIEADELRRYGQRLNPPLNHRYDQGREASMSDDASQSGSDAEPPRQTTAAQFTARAAFEHSFFEESEDDENVEDEEAELTPGESEDSDLRSFNAEGDYYGNASLRSSPTPPPAVKQVPFTRATKPSRPPSSFLPSQPDAENGQHDQSTPSRLSEAPTSAWGAFKSLLGGKGLAPVSPPDSDTQLSQGASTGRLPEQHQSTARLRAPQQSNIAAQRTVLPRNDGLIGHAAPTTSSWRTSSKSPSQPGPLFPSDHSEMDDAMQDDIRESEGPDRRIRQDNWWRVLASLCPCTSRRQPQRPDWQNGELGSPTFSTPEFDEDSELDSALTDDSINWQQLFNPLTYLRAISWFFSAALESVVNLFSGLFTDSLRDRLMRIGEVLVYTVSGFSFVLLAVVLSSIAIANLPSFEEAPLVSVPSVPVPRFPGLGDLTSQIGRLIPSIPWSSRSAWDDFPGLDELRGDQYADFQDLINQVLRDLRLMKGAGKLHESSLEKLNAIVPKMVHMTLKDGKPVVTQEFWHAIRDLIEKDGSFPMLKKSRGGHYEPSAEKQWKDIAAWLAARPEMASKINEANDGLAKKVPHMWEAWATDNQRKVEQTLRPILDKMKITGSLSDKDLDKRLDQLVKKHMGSNKSGSTIVTRDYFLQYLQNEFATHRAEMMAEISELQPRLEQLIRDSVDLARKETDESSSMTRTEVTKLVDSLVRKAIADLNLEAMAKGRIRAHWDSELKNQLNYFGVGAGAIIDPSQTSTTFKPDAKHLNDKGLKGAQPYAPIEALLPWHDDGDCWCAAREVNKRGNPHGAKLSVIMAHSIIPQHIVIEHILPGATTNPGARPRQIEVYIKVEDRTVRERLLDFAAAHLVEDDSDWNHTPADLPPQFVKVTQFTYEGAELHDGVHVHRLSNELMALHAETDQVIVRAVSNYGAPNHTCFYRIRLFGHKVPELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5M1</accession>
    <name>A0A2T4C5M1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer membrane protein, beta-barrel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1391402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5M1"/>
    <dbReference type="STRING" id="983965.A0A2T4C5M1"/>
    <dbReference type="OrthoDB" id="3549121at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32666" checksum="D728173686E11675" modified="2018-07-18" version="1">MATDTETLSLPTTTAPTEVAASTCLPHDEHQCRGLKREWCADEWDTGIATSLHFPAQLGGPSNAATSPQHQTHQPHHPQDQGGDATVTGKYVAQPNPDECDRPLKRRPSSDCWLTSTLLSSYRSVEEACKRSLEHFPCPSVSFAMPTLEFDFRIAVALNPEPSRIENRVQKEITTIKGGRWSGSFGNGRVMAGGYDLGQARGFRPIRIVEGAFVLQTTDQPPAMLEMRTRGSLSGPCDILDTLLSARESKDNIDPRQYGFRTFATVKTADKRYAEFVNCGLWVASGVWRGEELIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5S4</accession>
    <name>A0A2T4C5S4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1237254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5S4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="21531" checksum="14E9807F5C5426AF" modified="2018-07-18" version="1">MASGLTTQIECYYQTEVYFSTFCLGHGRLHYWHAFSNITKAKAQISPRRRPKRWTGTNRAVNAHPGRGLTGPAGLATSLSETSRRRRLLPFDFASLLSFCLPVGSFDVASLGLANAHKRRWGPRRECVAPFSASSAWLHFVHLERSSWSVRVVMRSLSIYLFQLKSRSLCAATLRLVFTLSSQYHCWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6I7</accession>
    <name>A0A2T4C6I7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1376728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6I7"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="117"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="355" mass="40866" checksum="36550E912DDBD7E1" modified="2018-07-18" version="1">MGEASEKLPAIPSEITPEWLGEKLGHKIKSIENTSNIWGTASKLFYTITYEEESNEERPRHICIKGVFDPKMIEAQPWTVSLAQRESQFFTKVAPNVKNMIFPKSWWSGMSDKQGIAIMNDLTTEGCTFPTETASYPVEKVMNGVEQLAGLHAQYWGQSQDDHPWIWNNYDPAMKFMCTPWDQVVRTPGRPQLPEYLMDGTRCNEALDRYYAERNPRFRTLLHGDTHIGNVYFTSSGRIGFLDWSAFHFGSCFHDVVYHMTAMLSIEDRRAHEMEILDHYLETLHRLGGPKLDRHNDPEVMIEYKRSFMTNVIWLICPDGLQSKERVAVLCERTVATYDDHKVLDVILGQPKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6P9</accession>
    <name>A0A2T4C6P9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1469291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6P9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6P9"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118646" checksum="8EBC2415837D2B9A" modified="2018-07-18" version="1">MLTPTTLHRFRWFNAFGNAPAINLARSIPHGQDASVLSLGRGDLSSILYTSYVQRGLPGRMLDITCCNDDENITARNLVLLTMILVEGEDISLQVLWDVYYHMFLDEHTTELVDRHVRSIIPMLESLESFNNGSYGSIIKMCDEDTLEPSLDLAAIRAASPLALARSCAGPPHNHHYWNEVVAMINGKNYRSPNPLLIGLVSDWKILHCGSDPVLSFHLATAFTSLAADSPLRHDGDDEEHKVVAAARSQFFAWVRAFRSVKDSMCVRFAVSDPFAFCHTLQYADAAGQLSANWYRRQWDSRVLRLDENSYGLGGDAPTSFDAIDTSNLSEDFGLVNVLVSAGPLLTERLWATLLTEDIVDNDSSEKHPLDQLLHDSSSTVSLLLGLVPLQCWTTARAESSLREMVTLTVPPQLVPTRFPVCLSWKRDDQLGDCNAEQLKLHMNFNEVVEMLFQMYLDMFEAETAKAFASPSENKSRNQPRFHRGSFMALLKVIQSRVKSDWNAVIDGLLRRIGEERTLSLAARQGQDLHLQLALFDTRPLEETGAMQIPSVSLLSRWKHVPPVVAVTLIVPRGALRDFFPEPYPTWPVPTLVGTLKSSGIMSRRRYSIFDDVHIVFGRVTTTEQDELCWSGTSPLVATFLVPTSALAGQPVTDVVGLELSTASPSTTFFIEVLGMSQRTVHEAALSNTTSVFITKLMPGTTAHKITSGGVRQLKDEVTGAESEARMMLMAKLSPERRGITSLSALIQVPSESCKTNSQNRPPFELYQNNPFSISIILDKHKFICPGVDRTSAYFKVVAPLAEPSQSSVLQNCFSFSILSPGGLPVAMNLSHINLDNLAVIELDQPERLAWLTTLTSLQIPRHNRGGHTEDVRARFGATLSAMFKACSGTLERQTCMFSLSGRQRDDVQAMIFVSAVRLDGDTASVVLDAAILPLMSQYLASGDSDDFLKELKVQDGMTLKVDDEEMALWKKTTPSFIERCRTWNHLPSCEYTKQRATVPLSCEPGQPWICSCGHGRMPDGFIAAPSWHLAEKHAVRIAISPMYHAPLDTMKDVLGRRGLYVGVRSGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6V2</accession>
    <name>A0A2T4C6V2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1469282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6V2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6V2"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF1">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="288" mass="31428" checksum="2E3B7093DBE9FF50" modified="2018-07-18" version="1">MSGYGYQGGDYGHQGGEYGHQGGDYGQHNNQYPPQHNQQYPPQHGNQYPPQHNQYPPQQGHAGGSASSYYEGASAEQQQQQYHTLYQQPPPPYPSDGPGYGAAPQEGERGLMGALAGGAAGAFGGSKLGGQATGHAKTSGVVGAIVGAIAGSKLQDGVSDWRHERKEEKHEADMYKEEKKEKKEKKHKDERRSRSRSRSSRSRSRSSSSSSSGSSRHRHHHRRHSHSRSRSGSRSRGHGGTVTVQAGDTLREIAARYGTSFEEIARHNGIQNPDMIYPGQVLRVPGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6Y0</accession>
    <name>A0A2T4C6Y0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1429933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6Y0"/>
    <dbReference type="STRING" id="983965.A0A2T4C6Y0"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015705496" evidence="2">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="513" mass="56202" checksum="2DDC9BDB9C2D5E40" modified="2018-07-18" version="1">MFRRALLVLAILGALVAVFLARQSAQEEEILISGRNNTVLLLTDSHHGLCNVHLATVSALIENHPSLEVHYASFAGIASDIERITEIVKKSANPQAKIHWHQYDGPSLVDEMSVAGGVQSIIAPPGLSGLKEFVEMVAFAVTAWSNEAHLSLYHQTADLIREIDPAVVVLDSMFRPAIDAAISLNRTRAYVTPNALTDLLAGVQPKGALFWKYPGIASGLPFPVPWKEIPNNIYQQVYFIIKYLTSPTIRNKRSWLEQHGVPRAVSLFEMFRQDVPWIAMGYPEAGYPIEVIPDNFHIVGPLVLDVAPAETQSAELAAWIKKAPTILVNLGSGFRYDETRAVVMAKAIALVLDASDAQILWKMRKTGKYGDAFREPLSKYVEAGRLRLESWLEVDPTSLFKTGDIAVSVHHGGANCFYEAVLAGIPSVVLPLWADLYNYAQTAEYLGVGIWPNKTLAPDWDAAGLAEAFLEVLSGNRSAAMRENAKALARRGEEYGGRKVAARLIAEMAAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C893</accession>
    <name>A0A2T4C893_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_292171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C893"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="86" mass="9346" checksum="79470EEE2315E5E1" modified="2018-07-18" version="1">MHFAGPAVMLQVLSNCACSHVKVTIDSHICFFALSCVYVLTQSSIDGYLKNSLHRLSASRIKPSYGSRKPAALLKVRGAQKHTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8B6</accession>
    <name>A0A2T4C8B6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1400707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8B6"/>
    <dbReference type="STRING" id="983965.A0A2T4C8B6"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="306" mass="33486" checksum="1054F6BCD7FBBC49" modified="2018-07-18" version="1">MSRSLLITGATGRQGGAAIRALLSKNADFKLLAVTRDKTSPSAQKLASLSPKVTLLQGDLNKTDALFEQARDLTGSSPWGVFSVQALQPGAKGPPLEQAQGTSLIDSALKAGVKHFVYSSVDRHGEKSFANPTDIPHFISKHNIEHHLVNATTKSHQMSWTILRPVAFMDNLDGGFLGKIFATAIRAKLSPGNKPLQLVATEDIGEVAAEAFRRPDEYSGKAISLAGDEVTFQQLSDIFREKTGSPVPVTWDFMAKLVFAASKEMRTMFDFFEKEGYGADIAALRTQYPQLKDLRTWLETSPYMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8D8</accession>
    <name>A0A2T4C8D8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_361686</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C8D8"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB77839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="136" mass="14617" checksum="0E1B58D6D014E51A" modified="2018-07-18" version="1">MSAQYSYQDVAEHNTKKDLFLVIHDKVYDCTKFVDEHPGGEEVILDVAGQDATEXXXXXXXXXXXLLFLLSSLLTFDSFQPGDPVPKTTTTSSPSVGSSTTGGGFGLYSVVAVGGLIAYFAYQYLQAKEANQAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8F4</accession>
    <name>A0A2T4C8F4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8F4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015693225" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16985" checksum="9EEACB935AB63AD8" modified="2018-07-18" version="1">MGWPPLPLFSSSLTRALLSLSLPPLSPLLPTPSSLRCSFGCFPLSFSPLGTNPGPCNIPYSKTLNCLLQSRRLCWPVLFSGHWQLASSTGIDRVVFRHQRFSLATGLVPTFSTWLVTYCSFSAGQKNTPPVAADRLLTPTSRTTPYQGSVFFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8N7</accession>
    <name>A0A2T4C8N7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1421656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8N7"/>
    <dbReference type="STRING" id="983965.A0A2T4C8N7"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015480232" description="Ribosomal protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="10976" checksum="844C7F839D868BF6" modified="2018-07-18" version="1">MASFLRTLSLTAGLLRSSPAAAAAVAKGSFATANPVSAWMGWMARPAVGGALQQTRGMKVHSSVKKRCEHCKVVRRKAGKRHNGYLYIICKANPRHKQRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8S7</accession>
    <name>A0A2T4C8S7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1421649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family. ARP4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8S7"/>
    <dbReference type="STRING" id="983965.A0A2T4C8S7"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000137">
        <property type="entry name" value="Actin-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB77922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="467" mass="52026" checksum="1014C9154065BDB0" modified="2018-07-18" version="1">MAQQPLPTSAQPTDIYGGDEVSALVLDPGYCNTRAGYAGEDVPKSILPSFYGHITSDPPRDLFGDECIIPRGDFEVRNYMNKDSVVEDWDVAAKLWEFMLVKRLQPERQTPPSKNGLNDDVKEQDGEGDVAMEEVEGLEKPLEEFPLLMSEAPWNSPKAREKAIELSMESWGTPAFWLSRTPVLASFAAGKATALVIDVGGANTSVTAIHDGMVLKRSIQRSPAGGLWLSSQIRKMWETSEPKVDLVPTFMVENKTPVDALAPPQARLREFPYKIHDSFRAFEEERVLTEFKESVVEVWRGPGRYGAAGNEEYIKSQPGRVFEMPDGYNQMWREQRFKVAEGMWDENAGYPVSEEERLSKAQTIPELIRSALNSVDVDLRGTLLGNVVVTGSTSLINGFNDRLNNELTAMYPGLKIKIHAAGLSSERRFGAWIGGSILASLGTFHQMWISKKEYEENGAGIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C968</accession>
    <name>A0A2T4C968_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_17731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C968"/>
    <dbReference type="STRING" id="983965.A0A2T4C968"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015519441" evidence="3">
        <location>
            <begin position="28"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB78109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="267" mass="29357" checksum="ECD55D08EF08A0CA" modified="2018-07-18" version="1">MPSPRRMRLLMVAVVITVVFVLFYSSGIEPESDVSFKGFYEKTKEAMERGTARGQPVINAKTGEKAGHIPADRDGDGDIDGDDKVAAQELQERLQAVEREAKDKANEKSPKPDIPSRIVGVGSSAEGQVKKGQVKAGGEVKEETKEEHEAEVEINSILKKSPVIIFSKSYCPYSKRAKGILLEKYTITPEPFVVELDEHPLGPHLQDYLLKKTGRRTVPNILINGVSIGGADDLVALDNEDKLVAKVRDLGQARVEISERFTPGEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C978</accession>
    <name>A0A2T4C978_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1399288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C978"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="67" mass="7664" checksum="954BC58693CC4CCF" modified="2018-07-18" version="1">MYWYALYHEVETTYLQTMHRRLDTPTRLTLMPISLIVAAAHESLLDLIKVFSASHSISAIKLSETGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAB0</accession>
    <name>A0A2T4CAB0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_262897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAB0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="202" mass="22652" checksum="EB2C87457703CFCA" modified="2018-07-18" version="1">MYPGPWLLSSKNTPWGRYETIDRSNRQQELFICFSNQGSWCTFCLTCIRSLPSKKQCKQEHVLQPWNREDTIPVFLALDLSPAAVRSTIRLLPLVSSPPLESGPLHELRRRRRCAGGIHSRSSRSRLEGGGKKPMVLLQVHYSPGPVAVHLQFGNGKPFDLATGLVASLWRCSSTRPETQPASQPMARTTPDAHPELLTLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAB9</accession>
    <name>A0A2T4CAB9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1327903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAB9"/>
    <dbReference type="STRING" id="983965.A0A2T4CAB9"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB78493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="233" mass="25734" checksum="008F26AD4AE32FB8" modified="2018-07-18" version="1">MGRELQKKKRRSGRPPVRQSNRTKKILNPRGNSVIAKNWDKNETLAQNYRRLGLLARLKTPTGGTEKKLLSSDSSSAPATKTTPATSKPDPFAITTTEKAILSEAKVERDAAGNIVRVLGRKANPLNDPLNELDSSSEQEDDDDGDDGEEWGGINDDGVGTTDVVKSLIEEAKNPAPPKVRYLSERETEWLETLVAKYGDDTRAMARDIKLNPMQQTAADIAKRLKKLKAQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAH4</accession>
    <name>A0A2T4CAH4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1329761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAH4"/>
    <dbReference type="OrthoDB" id="3436397at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="12681" checksum="42AE823F75F842A8" modified="2018-07-18" version="1">MHSPKKDHQDTAEEPPTFKEQLDKEAVESRTHQHQGESGEHSTVKAVVDKIASVIPASVPFIGGGSHPDENKVEQKPEPKIPPRRPEHDPQIEEFVRDQHRSNEPEIVASSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAQ5</accession>
    <name>A0A2T4CAQ5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1437508</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAQ5"/>
    <dbReference type="STRING" id="983965.A0A2T4CAQ5"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="107"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB78651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="545" mass="61492" checksum="027203ADC7E14B4C" modified="2018-07-18" version="1">MAFRWARRFERACCTTAKYFPLAFVYGLTSWACWVVVSIGSQSDGTRWIGSTSSFFGVLLYLLLNWSYTTAVFTDPGSTTNNDGYGLLPTSGNQHRTATSFTVKSNGEIRFCKKCQARKPDRTHHCSTCRRCVLKMDHHCPWLASCIGLRNYKPFLLFLVYTTIFSFYCFAVSGTWFWTEVMDDNKYLDTLLPINFIMLAVMSGIIGLVVGAFTTWHIMLACRNQTTIECLEKTRYLSTVKRTLHQAQGLANGIPQARQFVDFHATALPGITTREEGEERRSQEPMPRAHMSYEELERYQSRKRYEEYLDEQDSEKLPNAFDLGWKRNLLHLLGPSPLLWFFPICNTTGDGWSWEPNPKWVAERERLKSAREEQRQREVNAGWGYGGDVPSPTADVTGNYHGRGPLVNGVNGGARRAPSKADRILGRDPNLYADGSQDVPMRRLSPRGHATLPEDDLLETDEEEQQQQHQQQTQTHRHGSQTAASRREAERVAMSVVTNTRPWGRGGASGMLRQGSQHSAGSGSGNGNNSRVVSPSSEVNDDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAX8</accession>
    <name>A0A2T4CAX8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_50315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAX8"/>
    <dbReference type="STRING" id="983965.A0A2T4CAX8"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="197" mass="21804" checksum="3162A154B1A9022F" modified="2018-07-18" version="1">MKAPLQLDFAKNPRNKVWAVNNDPARLDEVYNRLLGPGGSKMLPEELKWLAVTHKSFDQGRRGFNDRLALLGRLTMVMEATKEIVSKEPLAGSILPDQFDRQPLDDAQLLAVDNLNVMGPRDVIGKDKLYQLANKVGLLEVVRWKPRLPKRLESSGVEVVLSSAIMAIVGAITLQHGAAVAAQVVRERILAQVPKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB50</accession>
    <name>A0A2T4CB50_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1201733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB50"/>
    <dbReference type="OrthoDB" id="5242800at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="93" mass="10287" checksum="B2979C04632E5A17" modified="2018-07-18" version="1">MEQQRPVIRSPALRLVPAGFAIKGPPAVSPVPVEPQRIMAAEADGQERHRPEPLVAPLAQRSETPDTEHARPRKRTRRACDKCSASRTRCDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBQ7</accession>
    <name>A0A2T4CBQ7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1398268</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4CBQ7"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="329"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB79007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="447" mass="47536" checksum="98EE63B704EE6F05" modified="2018-07-18" version="1">MSLTNGSPEAAAAAARDASFTLASLPASARNEALDAIHAALTASKDEILAANARDLELARKAAADGALSQALVSRLDLGKKGKWEDMLQGILDVRDLEDPVGKTQLRTKLDDDLILERVSCPIGVLLIIFEARPEVIANIASLAIKSGNAAILKGGKESTESFVAISQVISSALSKTQVPNSAIQLVTTRDAILQLLSQDRNIDLVIPRGSNELVRYIKEHTKIPVLGHADGLCSIYLTATADKHKAAVAIVDSKTSYPAACNSVETLLVQDQALVTIWPGVAAALAEKGVTLRLDAASKAALAGFPFPEGSIQDATPQDYDTEHLSLVLAVKTVSGVDEAIAHINAHGSHHTDSIFTADGAEAEHFMNRVDSAGVYWNASTRLADGMRYGFGTEVGISTNKIHSRGPVGLDGLTIYKYKIRGDYQPTTGYGEGEGKRPWKHERLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBX5</accession>
    <name>A0A2T4CBX5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1436439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBX5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBX5"/>
    <dbReference type="OrthoDB" id="4814848at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="534" mass="58934" checksum="D076E01932983D2A" modified="2018-07-18" version="1">MDVYNARGNVMAPNVSPLYQRDANGGPSTTWYEHHPSYVHDSVTPHGTQPSPFMKECFEDRFAFTTAGNAHHSTWSPNPSAGPAWYPSEPSPGLLLNSEYDGASGSFTGYGTDNVNSEYEAQLPWPEPDPFASDSNVEELNPFQDTYYASSGAEGNPDAVCDPEMTLQPLSGGVGGIMSGSLPQQPVYGTSPGFVPLGRYRSQGSPEEPVPTSMVFANSSQPSLYISSPLSVVSPPPSAGSSSRKRNPAAADLEKSPVAPKKRVIKPQLTAKVDNSEDFEIQKDSEMPPTGVYQGYFQNRDEARRKLQRLLEMYRKPKENCSYPSNDDTFPVTDAGKIAYIKKLFDAINDWSNFREWSQALKTEDRNRIIDRLRRGHAGGDNGDNGDNAEADISLDDMRPSPQELEAILPPLEAQQKKILGRLLSDQTVEWLCWELIEAYDSFAQRIEAMCYALRLVKSLLSAGDGWKLRIANNPQGELGHKGNNMKVNMNKNRKLRQITQGTRTTARPKPTSKTASKPAPKQSEKQAQKQAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDR5</accession>
    <name>A0A2T4CDR5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxy terminal WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1326241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDR5"/>
    <dbReference type="STRING" id="983965.A0A2T4CDR5"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000020">
        <property type="entry name" value="Peroxisomal ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015625730" evidence="8">
        <location>
            <begin position="20"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="528"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="638"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="744"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="446"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB79693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="840" mass="88252" checksum="8F0D04728CCCBF09" modified="2018-07-18" version="1">MKSTAALLALLGLTGSALADPTWPNAIDEIEEIMTQLQSFRARKFADTVSPCSNEASGPGRQNAAEWLRVGFHDMSTANTYFGIGGLDGSLQYELDNGENTGPGHRTTLEFMAPYVSPRSTLADLIALGVYTSVRSCGGPAVPIRIDKNSDFKVFNADGNQTMEALADADTFKSVCKTVLQKMIDVVPPSVKLTDPIVPYKVKPVNLQLTLINGGSTLQLTGFIRVKTTGLAQGSISSVSITYKNRRGTTDCGLSTCVVTSTVQGASQGFDDTFAFYPISANILASSGISSFTVTINNADGTKDIYDNNGNEYPVQDAIIFQSPQSCVLGSSGALTAVAAVRNDRLSQGAQVKVWYKTPQTNSPVPLLQSTTLDLNKGQCAGAYTLFTVDHTIEGGLAYEGYVDVINGDQSDSFKALTSVGGTCRAFANPAACVGGDDEGSGGTTGVTTVPTTTEALPTTTEPTTEPTTEPPTTTEPPTTTEPPTTTEPPTTTEPVTSPPITEPPTTTAPATTTSPPPVPSHRPAVDGYVLVSCWTEGDGVRALAGNAYANDSMTLESCRDFCSNYVYWGTEYGRECYCGNTLAKSSGEAPIDECNMVCAGDASEYCGAGNRLELYSTTVTQPPAPTGTLTHEPTVGPYTLVGCWTEGSGDRALGQKATIEPDMTNEACAEFCSDFRYFGTEYGDECYCGSFLAGSSATAPLADCNMPCAGNEFEYCGASNRLELYINPNITGGTPEQPAAAGDFVFVGCQTEGNGTRALTGAAAATGTMTVEACAEFCADFTYFGTEYGSECYCGNTLAPSSLKAPAADCNMLCSGNELEYCGAGNRLSLYTKKPEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDU4</accession>
    <name>A0A2T4CDU4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor eIF4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1327412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDU4"/>
    <dbReference type="STRING" id="983965.A0A2T4CDU4"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000016">
        <property type="entry name" value="Translation initiation factor eIF4E, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB79714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="262" mass="29326" checksum="D86EDFD404A09E1A" modified="2018-07-18" version="1">MATRPQLFTRGLSGLSQSSSAGDISSPAEQRDDAKRNLFKTMRPLPTQHYWDVYFDRSQKPEGGAGQEYTSQLEKIGAPIESVQDFWRYNNNTPVENIKMRESLYLFKSGFRPVWEDRRNINGGSWTFRVPKAIGPDFWTRIQLLAIGEKLQSVIDEADQICGVGLSVRFNSHLITVWHRDSSKQNSIDAIIKCILEELPPELQPKQDNYFYKKHSDHAGFKAPPQLQAVLDSQKRNAAAAAAAAAAAPDKPAVTVEPPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDZ9</accession>
    <name>A0A2T4CDZ9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_248599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDZ9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015692308" description="Secreted protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10269" checksum="B855BDDC6F53D03F" modified="2018-07-18" version="1">MISRSSALIVCFYAFIIWHWPLKCTVQQLLEIIRCPDHAGKFMLRSPPRETKSSYRPSVEAGTGRAGRAGILGSPLQGGASGIRRGWRVSQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE48</accession>
    <name>A0A2T4CE48_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1372185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE48"/>
    <dbReference type="STRING" id="983965.A0A2T4CE48"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF5">
        <property type="entry name" value="ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="106"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB79849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="406" mass="44359" checksum="875F64F777554F6B" modified="2018-07-18" version="1">MAATEAESLHSTGPAAAAPNPFNFQTQVISTAPVKSQNVGQRRGHRYKHSSVSAQHQIFQEPPPRPPPVLPASLPTPTIKEAWKSLQRDQRMRLYWGLCHVAIAMYIFYRSGGSLAAMALSHLVFFDAGSAAVCVVVDVLGNFEVWRRSSIRHPFGLERAEILAGFAMSIFLLFGGFDLLSHNLKHILESVGDHEAHHEHGDDGHDHERISLGLVSAAAIASTLVSAYGLKNHARIAKVMRVSYLATLPSILSNPFHFFTLFFSALISLLPLLSISLYAWLDRLICAVISLAMFSLGMRVAVAQGLMLLMSYGGNRGDVGVTAVLREIESESGIARVDTAQFWQVHYGLCMANLKLIITNGYDELALAKLRNRISALIQNRLGEGYGNGGNVRWEVTLETTMGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF30</accession>
    <name>A0A2T4CF30_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1369061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF30"/>
    <dbReference type="STRING" id="983965.A0A2T4CF30"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="187" mass="20208" checksum="CD48CD722B4B5D81" modified="2018-07-18" version="1">MTDIPTIMPDVERLGSQLDSLEDALEPLLGNLSEMSSQLPLLDRAKLFSMAAYAIESLLFSSLKIQGVDAQNHAVFAELKRIQQYFAKIKAAEEPAGQRKLVVNQEAATRILKADLSDNKPLSAKLAEKIAEERARALLKSAESKKRAAEDATQPTSSGADGASPSGQSKNKKPKTKGKSKSTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFI5</accession>
    <name>A0A2T4CFI5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1325061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFI5"/>
    <dbReference type="STRING" id="983965.A0A2T4CFI5"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="366" mass="41508" checksum="A6091A5930EDD920" modified="2018-07-18" version="1">MGQQPTPEQIQQIQRKIAEDAQKAGMTVPEFIEHIKQQQMARMRAMQQAAAQQQQQQGGHEGHNHPHPHPHPHPHQQQGQPQPITPGPPNPKGLAVAKFLRSQDLKTRTSILNGERKDMFKVKRALRALQSPAYEKARKKNPLLPEITDRASLENTFKLLPLSMLALRVTKIEPQPGPNGKKPKRVKGQWNVRIEQQQEAKEDMYYVWLWEGSQVKRQLYAALALVIIFAVVLYPLWPLKLRQGVYYLSWGMLGLLGLFFAMAIFRVILFCVTYFVVPPGLWLYPNLWEDVSFMDSFRPVWAWHETEKPKKKKKSKSVAANSAVAAATGQVAPATATTTGTETQVNVAPQQQKAYEAPKVEELADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFM2</accession>
    <name>A0A2T4CFM2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1324516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFM2"/>
    <dbReference type="STRING" id="983965.A0A2T4CFM2"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="211"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB80346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="401" mass="45503" checksum="93EC0D4647E0C037" modified="2018-07-18" version="1">MLSSLHPLVEQETLLDVLLAHDGSVSQASESLKAFRPAARKSAVIGHQRSLRQYTNSATTGDDGSSSPSKKKAKSKRGSTLHLYDPEDVAEHTPCTIVHNFLPAELADELLRELLHEAESFEKITFKLFDNIVSSPHTSCLFLESYEEIQEQKHDYYYNGGMLNDVRKLTPTLAKVKPIVQETVNEQIQIRIRTRYPGGKKLRHQPSKPWVPNAAFVNCYAGAQQSVGWHSDHLTYLGPRAVIGSISLGVAREFRVRKILPRDAETTRPEDLDGEGQISIHLPHNSLLVMHAEMQEEWKHSISPALSIDPHPVSGNKRINITYRDYRPEMHPSLTPRCQCNIPCVLRVVQRKKENHGRYFWMCYSNAIPDKDGCSFFQWAEFDEEGIPISRTRTTTTTKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGJ3</accession>
    <name>A0A2T4CGJ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1370054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGJ3"/>
    <dbReference type="OrthoDB" id="2947935at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015709947" description="Cyanovirin-N domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="3">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="211" mass="22496" checksum="86B3EDCF009BCAA1" modified="2018-07-18" version="1">MKSLSVLLLTLASVAAAVPANKYLPVITPTPVVARQLPTPAVAVILPPPVHAHPHALHLPGFNRLSPNNNDNNTNNNNKSAPANDDGTTCEQITLGGNGKVGKTTLEGKCTNNKGEWWKTSINLNECITNVGGKLQYLPDGGFDATCRPCTIDTVPGGAEINLKCNCLDWKRIPKFTYLEMGDRVDTSGAVKLVDGRFVCGDRVGDKSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH79</accession>
    <name>A0A2T4CH79_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1396047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH79"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="232" mass="25199" checksum="EF2CCA9086BA7471" modified="2018-07-18" version="1">MPCLAECASPPSSAPSPLQPAQKARSSAIPEGDDVGFKLLSAAYRYRPAHSSPSLIRAKVSGIALRITAYTHQCGTLSHLGGHFWSSKLTEPQRCDRARQRLAQCCQSCAPSNDVSTLIPHPFASGPKPPLVNHRIALPLPDSPSERALFQQVLHPWQPIFSRRRPSLRRLRPHSTHPPPARAARCRRGRCLVPAIVEACKVASPILCLPHPPLLVVSSYLLSATPSASIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHD4</accession>
    <name>A0A2T4CHD4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1003374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHD4"/>
    <dbReference type="SMR" id="A0A2T4CHD4"/>
    <dbReference type="STRING" id="983965.A0A2T4CHD4"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB80960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="105" mass="11835" checksum="6C68DB611ED7F620" modified="2018-07-18" version="1">MAKEAPAKTGLAVGLNKGHKTTARVVKPRVSRTKGHLSKRTAFVREVVKEVAGLAPYERRVIELLRNSKDKRARKLAKKRLGTFGRAKRKVDELQRVIAESRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHL1</accession>
    <name>A0A2T4CHL1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional coactivator HFI1/ADA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1417790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHL1"/>
    <dbReference type="STRING" id="983965.A0A2T4CHL1"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48560" checksum="700A416C71FA0845" modified="2018-07-18" version="1">MPDIDPAALSRPAVSVSTPVLSTKSLTLTAPGSQKAVKTSQIIPSRIDLEPLYTALKAAISPEQWLIYKESTTEFLTGRLNQAEYSSRIDPILSSPTGEKDHLHNQLIAAIYGNVTREMPDAGLAPWVSANDKPTATTGSKPVSGDAAERRVKGEVMQLPARDRRRIKELTQNEYDPHESLANMFSESHRKPSVAADVPASAAGGINNMNFDLEIRKRYTQPLAVESGEFPDTGQIAGRMLPFCYEAGLVNGHASDAPQLMSVATETFIKEVLTQIFSRTRSNGPGDSGSAGYSVGTTWVQTHKYSKQLHREEDAAQRGEITRDKSGLLPIEAKAASERGPLGIADVRIALEMADCGISQFPIVSAQILYGYREGELENWTDYTWVNGEPPEPRVEEIFTNGEAELANGTNPDAMDVDTEMWWEGAETTDMDMLDSVLDSCLAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHU8</accession>
    <name>A0A2T4CHU8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1427075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHU8"/>
    <dbReference type="STRING" id="983965.A0A2T4CHU8"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="89" mass="9812" checksum="ED4D41027C767F9E" modified="2018-07-18" version="1">MLDKLVGLAMLVAASVIFLYYTIWTLLMPFVDDDHPLQNLFLPRVWAIRIPVILLLLGSAVVGSFVGMVMIRSNQKKAAKAKAAAKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHW9</accession>
    <name>A0A2T4CHW9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_63201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHW9"/>
    <dbReference type="STRING" id="983965.A0A2T4CHW9"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB81159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="51538" checksum="E25000580815B2A5" modified="2018-07-18" version="1">MDEYMFKFFLDECRVVDERTSYVEIFNYSDPFYNSVEEHALPMSETISLPKDKYMSMVRTLRLPFGAIETSSVVGPFFWCAYDQDDDDPHLHIVHRKSDVRKKGKTRGWEMMLSHAFKTGVTTGFIKGTPSSDIAPALKHLRGCSGQVGHPMLLSTIILSHDLSPANDEKQRDARDWLRRLENAVSMRDEVEEGEQYFQDGILSVDGLNRDLVECHSHVMWKRPQAYFVLVREMELCMERFKVAWMDARRDFLSEEEEEHRKTIDRLHRSMLARMEFYKVKLKGLENYIHTTLERLKVQREAREARLNLEIAGEQRRIAHASKRDSTAMKTISLMGALFLPGTYLASVFSMTFFNFDADADPVISNWLWVYFVITIPVTALIVGFWLWYDRRREARYANDDQKLEGDIEQMEMNILNSLRKRTMSKTHTWNSRSKPIHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHX1</accession>
    <name>A0A2T4CHX1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1459432</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CHX1"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="919"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1270"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1472"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1648"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1486"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1530"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1548"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1571"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1582"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1602"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1660"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1672"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1684"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1716"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1737"/>
            <end position="1771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1890" mass="211514" checksum="82B5987306016503" modified="2018-07-18" version="1">MDSFTPPLSSHNASGGTTDQDDPFLWDTETLSRELCCKGRPWLKHPDALAAKLAEEEMDGCTLLTYDFLFSKKELLECLGITTARAKAGLAETVLNFQARSKAFRSWKRNMLRNQSQLASDDDEKDKDIKNESSLASVAPQHPGSALKRSATRSPDRHLPDRPAEAHPEPYQAAASVDGILFESGGDSLMHIASGGTEFDQIVTSVNGATSPSCEPNNDPPPALRDEERTPKRRRLAPTNLSTNPLPGSDVLALKKAGSLNLVDTGKDRSNDAEASHADTPPEYAYLGAKGRHWRTVLSHFIPPDNPWLNLEGGGFAVVSWDYIVPPGQRIVTNSLIKRHLRENSRKKAALGRGNAPDRSPTPSDGSDEVLDLDDLPDSWDEETQREIDEEKAEMAAMEQELARNIPSERVEAILKDEIALMKTKWIETKLPRYQRKAYQLWMASKRNQKTNKEQIFRARRDAKHYDQRLKKLYAEIVANTWQTERELRTQACIMEQTLSDKFYTTWLIELLEKRDAPPKPLGMPKPKAKRPAPKSTQRPFGDEILTSSDEEEFIVPDEDGDSDDVIMLDAGEVPQGIFGSPMPHRTRNASLVPSDTESCMKLDLSRLESPEQLRDSKETAVYIDLISPIKAPDAEASDSKADKPLPSSDIFGVVPPMDQLGSLEMIGQHPPQHWARQKDRWRLLLCLLWKLPQTRREWTLRFLQDKTSSDAWQASVLLYRMIPFAQESDIGREERATVAFDITKLFLSCSQCRHYTDVRVMVLSKKDNDRIKRAESFFPTFHAFIRGWAPRFPKNSQIFRTDAFDDELGVDESEDSQLSSTESPSKLRKHAAREIVQNKEGVDLREREKRRAQELEARRVKLRAALATSNAISSDKSRLIINETKRDGQSFIYVNEEIGKRIKDHQINGVRFLWNQIIVDAETRQGCLLAHTMGLGKTMQVITFLVAVLEAANSHDETIRAQIPKDLRKSQTVILCPAGLVDNWLDEILMWSPRGLLGKVIKYEAALKGTDLRLAVIEEWERNGGVLVLGHTMFCNLDANVRRILTGAASLVICDEAHAMKSAESLLNKACREFRTRSRIALTGSPLSNNVQEYYSMIDWVAPNFLGPVEEFRDIYATPIEHGLWKDSSGYEKRKALKLLEVLKMNVAPKVQRATTQVVRHELPAKYEFVIFVEATPLQKRLYDIYLNEMAPTLENAKSTKVMRVIGASQHFALICNHPRCFRQKVLDASRAPATPGASAAAAAFPRSMISTVLKETIGDIANPTLSRKVELLLMILDEARAMKDKVLVFSHSILTLDYLGELFKQQGRAVCRLDGSTAVGKRQEQIKAFNTGDSEIYLISTRAGGVGLNIYGANRVVIFDFRWNPVSEQQAVGRAYRFGQEKTVYVYQFVTSGAFEEQLQNKNVFKMQLASRVVDKKNPAIFASKINGLLRPIRTKPAKDLSPFANRDKILDKLIEYAQPRGIIREIISTDTFEEEDPTNELTAEERRDAQELHDMERLKNTDPVRYRQMRDQRQRNEQIRANAEASRYTTTPLSTPRPRQQPYIPSSSAPAPVVPSNGYPQPMAPNTAVPSNGDSRPSATVPSTQPPAQTQPAAAVPSGSQAQGTPQFPSSAPMPIAGANTYILKSNQYVFQPPATPANMQLRQAVPSWAPGPPNDGQPTPGQPYQGGPYQGGPYYGGQYQGPYQGPHQGQPYQGQPYQGQPYQEQPIPGLSNLGQPTHGQPTPGRSTPGEATPKQQTPRPETEATLTGASLATSPSGRPSIFSQPRSQAKDEFQIELARLIAKQPVFAEDNLKLAKKFTAEIALAQRKQALGFLPDNARWRLLLSHLQKHPRFVPAILLGNYTPEYLASAPDDEIETRISVMNDESEVSFLRRLKRCTDPPDPSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI76</accession>
    <name>A0A2T4CI76_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1321376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5419666at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="312" mass="33338" checksum="738EA28176072C8D" modified="2018-07-18" version="1">MSLSRAFTTRKLKLGSDGADSKNPQRSHTLRHKISGPVQLVHTTNMLSYNAPDLPRGASERIASAKSGKNSLDDSDSLATIESTPPTSPDVAPGEHMLSPKSNHLSGYFKNSARPGPAEPEPAPVPAPMIPQRSPTHTKKNSIDAVARSRSVSRSSRDIDVSTASRNLQAISRTPSLSTRSSANSTCSSRPLRSPRSPAVAMEPTAFAAPHMASRAPAIPTPLSVQPSFAPQHKAKDSNPFGAELAQVTELAEEYSSASQLELTDEDTEYLRSKGLVRLRPDDYLSMIQGLSSIFFSEPSHSAPAAAAPLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI92</accession>
    <name>A0A2T4CI92_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_80889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI92"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="236" mass="25342" checksum="E93D04B8368988C8" modified="2018-07-18" version="1">MLLISSTTEMAWTSMDGLCLVYWAPDIRSPEAPITGRARPRRPASWSGGGDPFSFFGASRNARVMNLNGLGCDPRWSTRKPIRQQDPDMEQPCCFRQRCSTIPAGLSAAAFTLTKGQTHRVSASKSASGAPESGDAAFAHGCVSKQVVQLRQLPVLECCGLFRQWGVAAVWTQTLAANWTGAVLGVQATDRMYGKGRLCPAPCCVNARELDFPSATKTASMAPATSILERSALLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIQ4</accession>
    <name>A0A2T4CIQ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dpy-30-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1435209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIQ4"/>
    <dbReference type="STRING" id="983965.A0A2T4CIQ4"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB81423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14561" checksum="AF2B6924D8206B30" modified="2018-07-18" version="1">MADENSRSAPDVPQVSINDEASNPPSTQQSQGNADVTMADVPTDQASPAPAAFAHSPAPGRTGTPAQGSRAPSAHPDSGFTMPSEAPPHGDSTRRYLNTKVTGVLLEGMKVLSKEKPEDPLRVLGEYLIQRSKELEGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIT2</accession>
    <name>A0A2T4CIT2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_85445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIT2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015406127" evidence="2">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="129" mass="15067" checksum="9A35AFBFF70213BB" modified="2018-07-18" version="1">MRWMKWMSGMRQSILDLSLACGSVPAMLTSLGYSCLDGWQSMGKRRQRRERKKKKKKKSCMKIHARCECVPAAPIFFFFFFPYYLFLNSPSLALLCLTFSALFFPLFREDTRGQTLFPSSRQPSILSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ08</accession>
    <name>A0A2T4CJ08_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1018701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ08"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ08"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="161" mass="18516" checksum="C0BA18BFC558498D" modified="2018-07-18" version="1">MATGMRNKRVAKERQKIDKFGLPPGIELVEGNDLKEWLFDIRVLDSNPIYDGNIFRLKFVFSDTYPIVMISQEPPEVTFIERPNRPIPIHPHIYSNGIICLDLLGNQGWSPVQSAESVCMSIQSMLTSNTKNERPPGDEEFVRGNKQRPRDIEFLYHDNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJD0</accession>
    <name>A0A2T4CJD0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1314675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJD0"/>
    <dbReference type="OrthoDB" id="3443479at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="67" mass="7544" checksum="1E267850063A38F4" modified="2018-07-18" version="1" fragment="single">SCSQVMSELDRINHPEAWEGEGLTQLPFDMADECMPSWHNALLVSEAAVCNHYLGDGCLPEQRVPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJE5</accession>
    <name>A0A2T4CJE5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chromosome condensation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1396829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJE5"/>
    <dbReference type="STRING" id="983965.A0A2T4CJE5"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB81664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55580" checksum="2B98CEFC16575E5F" modified="2018-07-18" version="1">MASPSREPEAASRSSRGSYNAPAAYQNIDDGTAGLSVDIPDDRQAPATAAAAEAAASPSPVRPRRRSSAAGSRAYDIPDDWANLDELAATSPVENVAEAPIYRHRSLEQIRSRDRDERQRRRASVSQTRPPAEQFDVEEAAETKEGEEEEGGQRHVSRLATEIYTISYLVFFAIWGTLARVGLTALTTYPGVPVVFSVLWANFGGSLIMGFLSEDRMLFRYEWGSPTYDQLLARARENGNGEGSSGQGDQVIDLAAAKKAHLATKKTIPLYIGLATGFCGSFTSFSSFIRDIFLAMSNQMVTPGLGTPGRNGGYSFLALLAVTITTVSLSLAGLILGAHLAIALERFTPSIPYPVTRKILDPLGVLLGWGCWLGAVLMAIFPPHNRWRGEILFALVFAPLGCLARFYLSIHLNAKIASFPLGTFTANVGGTAVLGMAWDIAHARVGGLAGCQVLQGIEDGFCGCLTTISTWVAELSSLERRHSYVYGFSSVAAALAVMIAIMGGLRWSDGFSPLVCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJG3</accession>
    <name>A0A2T4CJG3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1346765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJG3"/>
    <dbReference type="STRING" id="983965.A0A2T4CJG3"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB81700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="179" mass="20133" checksum="20F88B94C3F2267E" modified="2018-07-18" version="1">MSQTIGLTRLAYSRVWHQISASKPHPTLTTQPNVTPPSLGRLASRIAVLLMGKHKPTFDPSTDCGDYVVVTNCAALHTTGNKMWRKKYYRHNTRPGSLRTVTMDVLMEKHGGSEVLRKAVSGMLPKNRLRDKRLARLKAFEGEAHPYKQNLIRFGGKVVGTEGWEKAVEAIRKTDQDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP69</accession>
    <name>A0A2T4BP69_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_69088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679154">
        <property type="protein sequence ID" value="PTB71080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP69"/>
    <dbReference type="STRING" id="983965.A0A2T4BP69"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB71080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="398" mass="45444" checksum="13A29E34751211DF" modified="2018-07-18" version="1">MVDSEASSPTWKFTQCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKSCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHYLLSTNDKTIKLWKVFEKSLKVVAENNLSHDVTPGGPVGGGGGLRALPTTQHFRNAADLKLPRLTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPISCNWFMYASSKGTIKLADMRESALCDQHAKLFEQEEDPSSRSFFSEIISSISDVRFSYDGRYVLSRDYLTVKIWDINMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAKNVMTGSYNNNFMIYPSDPDKEVEVLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP99</accession>
    <name>A0A2T4BP99_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N,O-diacetylmuramidase</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lysozyme CH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1434715</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP99"/>
    <dbReference type="STRING" id="983965.A0A2T4BP99"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06412">
        <property type="entry name" value="GH25_CH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015462143" description="N,O-diacetylmuramidase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB71145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="228" mass="24275" checksum="1A9D80F063BC88CD" modified="2018-07-18" version="1">MKLWTPLAIQLAALASVASATVPGFDISHYQATVDFAKAYADGARFVIIKATEGTTYTDPSFSDHYTKATNAGFIRGGYHFAQPASSSGAAQANYFLKHGGGWSSDGITLPGMLDLEYAPSGDSCYGLSASAMVSWINDFVNTYHAATTQYPLIYTSTSWWQLCTGNNGSFGSKSPLVIARYASSVGALPNGWSVYTIWQNSDASPWGGDSDIFNGNLAQLQKIARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPA5</accession>
    <name>A0A2T4BPA5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_222479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPA5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="150" mass="16966" checksum="FD4CDC8503CE0607" modified="2018-07-18" version="1">MIAMKAFEAKQIDQSLGILTFIKLPNCLQRRCYTDASQSRLWPALSVSCVRESQHRESVLVLYRSLSLPRSRTCTRAISRKPCKRLPLRQMLRTYKAPPSSQQTCLHQSVTTPAVEQDRNQAKFSSCIPPPCKLESAKPHDCGWLAAPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPM7</accession>
    <name>A0A2T4BPM7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1344606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679150">
        <property type="protein sequence ID" value="PTB71251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPM7"/>
    <dbReference type="STRING" id="983965.A0A2T4BPM7"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF270">
        <property type="entry name" value="O-ACYLTRANSFERASE AUSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="469" mass="53056" checksum="0D8310153C999203" modified="2018-07-18" version="1">MDWEYLSPIDQILPRTYFGEILCFPSTDEGLVSILRQGLSKVAVNVPQITSSVVNDESRPGNIRLDRGHDSIDNVLVYRENLAADMPDFETLRMASFPIFPNSSLFYPHVPEVPWAAPWPVMRAEVTRIRGGSILVVLAHHCVFDGVALSGLLDMWAASCRDPLGPPPEVRIEQMNRKAMLENLPSNYQRSQPSVIFTVSNTRQLMPDIFSRLQQSFTSILPKPSQPSWPITMYRLPFYKLRNLKISLNQYTSRFGLRFLSTNDVLCALIWSCATMAMSPKFQPWISSSLCSTGVSVNVRSKLQPRLPDDFLGCAIGIAYIDIARKHLLAAAEGRSLDMLASVAAAIRRGVDGVTNKSMRDIISYVETEENTSKLQWRPKRLNDFYIASWAHHRIYDADWGTAIGKCEALRVAQMSLMPMCVILPARSKLMSEESQPRDLEVAISLQSTHMERFRKMKLINEFAEIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRA1</accession>
    <name>A0A2T4BRA1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nagb/rpia/CoA transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1343409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRA1"/>
    <dbReference type="STRING" id="983965.A0A2T4BRA1"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18872">
        <property type="entry name" value="NUDIX_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="522" mass="57701" checksum="ABB87A3BD7B224DE" modified="2018-07-18" version="1">MTQLKECAVAVSFIFQFPDGDEQRTPRVALFRRSGQVNTYQHKLAPISGGVEVTDENPLATAWRELREETTLTPASLKLFRQGKPYSFADPDVGRRWTINPFGFILKPAEQGGSGEKGITIDWEHEGYEWFNPDEVTDDESFQGVPRLKESLRRVWFDIDLGKEAGAALAASLRSLQNDHESGAGLLAVAAYYHLYEDVIPKLDTSDRDRWWKNVRIAAWHVWKNGRECMSAPILHGMLSILETIDQRLQSSMEGSFTKEDVDRLCDNISDIRLQRDAAGAKIARNFSEFLDNFASIEDYSDGPDSPVKVVTLSASSTITDAICRGLTSPPPSWYVPIDLRVLESRPLFEGVKTARQISSAMQGNPHAKATSKLSVYTDASAALASRGAQVLLLGADLIDRFGNVCNKIGSLPAALAAKHVSPDIEVVVLTEKSKIYPFDPPPCEENDADEVVAAWKKAGVIGASGVWEMQGNGSVSNVYFEWVPADLVDVYLTEDGALNREELLELAARVEKQAGRFFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRB6</accession>
    <name>A0A2T4BRB6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1137177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRB6"/>
    <dbReference type="STRING" id="983965.A0A2T4BRB6"/>
    <dbReference type="OrthoDB" id="4944568at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015693209" description="Ecp2 effector protein-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB71816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="158" mass="16761" checksum="440875481396C772" modified="2018-07-18" version="1">MKSLSVLTTLAVAALVSAAPQKFQISNSTDVTWNPAPSDQTTCEPSSFFQAPIPNAADWRVCAAVSSAWASENGTFNIHDASGSAWIPVLKSEGCTLGVKASEQGQGPYIVGDQDIKAIFNIALEYYSEGTDLSVEGNVNCDVANGGRAGLQWQIYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRK2</accession>
    <name>A0A2T4BRK2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1466066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRK2"/>
    <dbReference type="STRING" id="983965.A0A2T4BRK2"/>
    <dbReference type="OrthoDB" id="5300765at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="571" mass="61747" checksum="8E3115F4E126B559" modified="2018-07-18" version="1">MAVNLAAIFRTLKPPRPGSKDKKSASSLGFQSFPPHFPCPSLSIIPFWFSFSLLCISFSTAIMSALAADVAFDFTFPSPSPSLEDPMTPPMESMPLMEAYSLDHYPSSLLELPFNQHSRHARSTSKASSIFSTSAVSAVDSITESACSRFTTPPRASPPVRQHGPLLLPKIRSQDQDISQSRMIPASHSRSNSIRAGRTRLAQQQSTPPPPASRPIHSSHSRSFTNPETLANMAFAHISPFATPPPQPLDETPAFPSTLLGSPASFAQDSLPPSRRTSCTIDPATIDKYGYPTYRQMPFVPAAPVASQQQSDYMFPSYLPRAPSPLSLAAAAASTDATPSTTLMEYLTCPNPAASLVRTISFPLRDPSIKHFWWDVRSVSSWSSFNASAILSLPGASALLHAPVPAPLLQTPAFSSRHPETEAALHSIYASYYLPKLNSALAMSSNRPGTESTPFFGDLEITSVQLNASDADFELDPSSSDGGVPLTACLALWGLCQIAGDHTPAGHAHWRAEIGAPADGTRRKAKARDTWIPKPQLAEKREAKRSRGWVWPEDPIGRKEMGKRGVKYGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRR8</accession>
    <name>A0A2T4BRR8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1465976</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB72008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRR8"/>
    <dbReference type="STRING" id="983965.A0A2T4BRR8"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="182"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB72008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="513" mass="54875" checksum="3AB1749CC6BE9D27" modified="2018-07-18" version="1">MFKSGVSSLARAARPSITARRAIRPAFPRTPLARLASTQSVGDGKIHQVIGAVVDVKFDTAKLPPILNALETTNNNQKLVLEVAQHLGENVVRCIAMDGTEGLVRGSKATDTGAPITIPVGPATLGRILNVTGDPIDERGPVKTDKFLPIHADPPAFTDQSTSAEILVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQETSVIQLDGESKVALVFGQMNEPPGARARVALTGLTIAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAVDMGGMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSTSRMLDPRIVGQEHYQTATRVQQILQEYKGLQDIIAILGMDELSEADKLTVERARKIQRFLSQPFTVAQVFTGIEGKLVDLKDTIASFKAILNGEGDSLPEAAFYMVGDLASAKAKGEKILAELEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS64</accession>
    <name>A0A2T4BS64_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1385326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS64"/>
    <dbReference type="STRING" id="983965.A0A2T4BS64"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="293"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="628" mass="69271" checksum="A366BB034A13F33D" modified="2018-07-18" version="1">MDPRRIIKSALATIQAISSHYENELEELADLPHEFTKVNQYLSLTQATLRYARDYPAWDESSQAAVHLLVTGVEKRAKMLQRVLSRVATDVERHTGDRSVLESYRIILSKLGKSYSVEALMLGILEDLNALSTNQLLKPANSNLFAELKDAMGEMSKVESSVEEADICSAGTQFTQHIASGGTGHQSHYSGQGQQINTGSGGITNYHATSINFADAFLLEAPSPQHNETNRQTDQSRYASRPVDGKNFDRGKDTGGLSGYFPHDHPETETLEGLNQRVTVRRGRPCRREDFQIAIICALPLEYDAVTLLFEQFWDENESFGRARGDTNSYTTGRMGTFDVVLALLPNMGTAAAAGAAASFRSSYCSLQLVFLVGICGGVPGKGVNQVHLGDVVISRSAVQYDLGKQYPETFITKDTTDYSLGRPNKNVRSLVALFESEFGRERLQQKASAHLEALQSEAVRKRRRSNYQYPGIDNDRLFPPTYRHKHRGAQVCVFCDDQSDGFCAEAAGTSCVELGCDESQLVERARSKENEPQQTEELRPRILVGQIASGSTVMKSGEHRDQVAREHNVIAFEMEGAGVWDEIPCIIVKGVCDYADSHKNDLWQPYAAAAAASVMKAALGRYDMADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSJ3</accession>
    <name>A0A2T4BSJ3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1095168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSJ3"/>
    <dbReference type="STRING" id="983965.A0A2T4BSJ3"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="532" mass="56756" checksum="3F4F90C799B9121C" modified="2018-07-18" version="1">MGELQSEADKIKLPGLLNATLDQLAEGLKSGHFTSVQLTEAYLKRIEQVNETVHAVVETNPNALAIARNLDEERASGTIRGPLHGIPILVKNNIATKDNLNTSAGSHLLLHATVPHDAFVIRKLRHAGAIILGKTNMSQWSNYRARDYGINGWSSHGGQTLAAYIANQNPSGSSSGSAVAADLGLAWAALGTETDGSIVAPAQRSGVVGFKPTVGLTSRSLVVPVSEHQDSVGVIARTVKDAAYLLQAIAGEDPDDERTAEIPGKIPNYVAACRDSLLGAQIGVPWKAINEGLEKYPHLASEIEVFKDAVLFMEIVGACVDEDVNFDSSTDDVRDAEKTIMRADFLGNIASYLSKLETNPSAIHTLADIRAKTQAHPLEAYPQRDTGIWDDILEHHNWDSTDPRFAPAYERLRQLGGPGGLPGVLERHRLDAVAMPTSMAAVWAAVAGAPVVTVPMGHHAATEPVHEDGGGGGMVETGPGVPIGMSFLGARWSEAKLFGIAHEFDQRMRLRGRGPARVVEPTAEIEARGAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSX5</accession>
    <name>A0A2T4BSX5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1394752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSX5"/>
    <dbReference type="OrthoDB" id="4964892at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="15462" checksum="D3FB75CF4B6202BA" modified="2018-07-18" version="1">MSKEVPSKSHNFALRLVQLIGAVGPRSGQPAPTLKSRWIPVAAADDFKPGEARLGRLGCIVAQYIQLRRTTFSIRDSRQIAAMAELVYHNGHYHHVSHRDRHRPRRNDDWSLVKFWDEVLYNIGDLYYKVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT07</accession>
    <name>A0A2T4BT07_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1394771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT07"/>
    <dbReference type="STRING" id="983965.A0A2T4BT07"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB72441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31087" checksum="7F58BE1AAFACDB97" modified="2018-07-18" version="1">MTSTGALANGHSLLDHGYDHVLRPRHAQALRTASDLDQHLTPGDSGMGSATTSQKSSGRSTPVSDNAPPSTKSLSSARKQVRAEQRRRIFPTIEFASRVSHFDPQSDYRDFHGFFNLFWIGLAIMGITTMLRNMKDTGYPMRVQIWALFADKLTDWMEFSREWNVPVYSFLRRHVYSASRPHTGKAFATFITFLISAVGHEIVMACITKKIRGYGFVCQMLQLPIVMMQRTKWVRGRKTLNNVCFWCSMILGLSLMEHQNIQGHKSKKKRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTB5</accession>
    <name>A0A2T4BTB5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1405549</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTB5"/>
    <dbReference type="STRING" id="983965.A0A2T4BTB5"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="13">
        <location>
            <begin position="268"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB72557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="625" mass="68996" checksum="2CE3E188EEB105E2" modified="2018-07-18" version="1">MAPDLPPIFLLPTHLQADEARELEAKVPSLTQDAREARVIVGKISRPERALFELRRLKLVTEPVAAEDVEGEGGDKGIKGEGEASKRARGSDAAVVDVPSKRQRLMMTGGGSRDGEGYDGTLDLLGGPEDVVLVVKLAWLLDSLERDVAQPVRDYLLYRGRKLPSQLSSKSQKDDEEASRQSHATRSSPSAVLARARQDQKNAPNSSPYSKRTSRPGTSSSTASDGARGRTEPPTLYHETTSEHDVPLPPIPEYLHTTYSCERPSPVNPPNAAFIAELKAIRTLRLLRGDAIGVRAYSTSIASLAAYPYAIQRPQEIERLPGCGVKIARLYQQWAITGSTEDTRGAETDTELAVLKMFYEIWGVGDVTARQFYNKGWRDLDDIVEYGWNSLSRVQQIGVKFYDEFQLRIPRQETEAISSVILAHARRVDPGFQMVVVGSYRRGKPTSGDVDVIVSHPDEAQTLGIIEKLVSSLEKSGFITHILSIWTRNSERGQAPLAWKGDDRPSGSGFDTLDKALVVWQDPGTKGEGGPHRRVDIIISPWKTAGCAILGWSGETTFQRDLRRYCKARLGLKFDSSGVRSRADGAWVDLEGAEGRPAPDMETAERRVFEGLDLEWRPPEERCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTD3</accession>
    <name>A0A2T4BTD3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_1341859</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTD3"/>
    <dbReference type="STRING" id="983965.A0A2T4BTD3"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="167"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB72555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="438" mass="48600" checksum="9520D02EC9C7010F" modified="2018-07-18" version="1">MPSPGGGSGSGSVFPVLTRLRDAAIELVFGRHPSKAAPTAPSFSPARYANQLVLRFNVTTADEEAALAEAAAQLLLDIWAFTDEYVDIRLAASQVAPLRSLLPRSLHHSQSILIPNLATDHQNLLLQQLLGADEVVAGAVGQTSVPRQEPSTVPGHVSARTSGGHCPMITKFLSHFDIVFIPVVNPDGVEYTWQVDRLWRKNRQPTKMQFCRGMDLDHAFGFGWDHAEASSEPCSESYGGEAPFQAFEASELARWAKNETQHNVKFVGLVDLHSYSQQVLFPYSYTCDTEPPNLENLEELAMGMAKAIRLSNGESYSVTSACEGAVAVKDSPDRHPVWPRIESGGGSAIDWFYHELGAHYSYQIKLRDTGSYGFLLPKEYIVPTGEEMFDAMKYYGDFLLGNNGIEKSVREQMEHVTSLAFDDTQETFTELRRRRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTI8</accession>
    <name>A0A2T4BTI8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1405062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTI8"/>
    <dbReference type="STRING" id="983965.A0A2T4BTI8"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="386" mass="45574" checksum="C942FB60089FB3B3" modified="2018-07-18" version="1">MGGGDLNLKKSFHPGLRRNQQAVYDEEQKALAERKRTQQRINEIKEERAKEEIQRQLEAAGGTKRVDRVDWMYQGPTDGQAGTTEETEAYLLGKRRIDNLIKGNEHKKLEKAAGQDSFIALQNANSARDTAAKIREDPLLAIKRQEQAAYEAMMNDPIRRRQLLSSMGIEDGKKKDKHGDGHSRRHRRHRSRDRDDDRHSRRHRSSSRSRSPRRRHHRHHRDDSDSDSGAGRRSHRERRRDHSQDREHRSIRRRDDSRDRDARSHRHDSYRDRDDRRHRHDDYNTREERPRKRSPRPHRERDDGAEDEQRAAEQARKLAAMQSAASDLDRDREARLAALEDRERAAREADDKARERGGDRGFVNGLHRKAMNMDKRSRRGYVRDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTQ1</accession>
    <name>A0A2T4BTQ1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_148367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTQ1"/>
    <dbReference type="STRING" id="983965.A0A2T4BTQ1"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="345" mass="36434" checksum="DF28C8AB2AC66BE4" modified="2018-07-18" version="1">MSYYDNPQWSAPAQNNWDHHGASTPVRAGANGPQPQDDFAFSYQFDEVDRAHENLQKSGKGYAMGARHGRMGGPRAHSVNTFDDSRGSPGANLHNFYAAQRHQSSRGSNEAEQVMQAKRRMAAQRERELRNLHTEQQYQRSVLSDVATTQQGNNKHMTEEETRELIARQRSALYGEGGFADKTGYIDETGAIRTGVPGPSGPASLRGHSPLTFDGIGRVPQADVGTPGSTVDINAADIGSRPQSTASPQTAGPTNKVFENAVGSQTRTSTSSPTNASPPRGDFGPGSKVSQGAAVAPIGTRPTGTPTGNASAKRSSTPHAANGGWGRGNGVWGQSGLGAQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU06</accession>
    <name>A0A2T4BU06_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M440DRAFT_1405248</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU06"/>
    <dbReference type="STRING" id="983965.A0A2T4BU06"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PTB72787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="276" mass="31258" checksum="BBED0C87EDEA5B33" modified="2018-07-18" version="1">MAALRSSSRILGSSARAAFRPSAVLSRSMATVSETTEQQPKIKSFQIYRWNPDTPTEKPRLQTYSIDLNKTGPMILDALIKIKNEQDPSLTFRRSCREGICGSCAMNINGQNTLACLCRIPAESSSDVKIYPLPHTYVVKDLVPDLTHFYKQYKSIEPYLQRDTPAEDGKEYRQSKADRKKLDGLYECILCACCSTSCPSYWWNAEEYLGPAILLQSYRWLVDSRDERKEARKAKLENSMSLYRCHTILNCTRTCPKGLNPGKAIAEIKKQMAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BU24</accession>
    <name>A0A2T4BU24_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1341545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BU24"/>
    <dbReference type="STRING" id="983965.A0A2T4BU24"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="34"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="811"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB72798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="837" mass="92123" checksum="E67007B2E0E27589" modified="2018-07-18" version="1">MAPLPDQLSSPGSVSYDSDTMTVGDGTWDFTKNTFLLPNLQGTDFDTTRYNGMGNRFSTVHQYHTIILAHGIMAAMVFLFLVPFSVMIARFYSREPGYAIRYHARLHVFACLLLLATFILPFFAVGPKRSLSNPHHGIGVAIFVMFLVQLIGGRIVHRITKLRSLRVTLHQWLGRAVAILGIVQIPLGLTLYGSPKVLFILYAVWMSFLLLLYFVLSYQSQGRREHYMSEVRSEAGNTRITESEYFSDHREHSHSKLAWLGPLAAAAGLFALTRGRDKDHRDDHSRVRSQSPSMRSRGPTVVSSRPSYFSEKYSDLPSQRDGGGGGGMLKALGGVAAAFGAGKLFANFMSRRDRRDEEYSAVSTETPHRNRSGRATTISEFNSEYTDDASTIPPSRAPAPTQTASAYGGRRSSPPPSHVRSDAPRRDVYDDSEYSSYVSPSRRTQDAGGGGGFAKGVLATLGVGWLAKKIANRRAKKEEDERLREEEEMRSGTQFSRYSNTEYSSPIRRDSRRPPPQRRSTVTGTEFSDTTESTFDTQTELSAMPKKGPLSAAVRVPPSTSALVPGDAPPPRRGERLSMPAMPSDPHGILHQSDGSASDMTSIVDRPAGRNPSRRHSTGASKMRGHDDKDRNVTLRRLTEEESLARRGRMDSQSSLSESPTKSRRYRRDDSQRRAESAAESRTESRAQDEDSRLGPLSPPSASHAKGRRGKDSGYYSGQPPPPYPVQPVPPAQAGPSTHLAPPHAPLPTASVSSIGSHGTAPPVTRPAAPPVVPPVVPSTVPPTEIKEDKGNESAADNRRRRRMERRRASSSRPAGTDMYTTDTYTTDTYDDTERGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUF9</accession>
    <name>A0A2T4BUF9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1340551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUF9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUF9"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="156"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB72951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="264" mass="30118" checksum="D1D390CDC94BBEDE" modified="2018-07-18" version="1">MSGLEEDHSSNGDDIRRQLSELRKSYSKLESRYQKLQEIGIRQAEQNFEQLKAQAEENTRAANELIAQLKGEVAEQSKSIQRAEQLQSRLGQSETEVEDLRAQLSAANQSLAQARSETKNLYTKLAASRHGETSSKGPATGNRAAQSEKESKQVAQVKEDLYADLTGLIVRDVRRIDKEDVFDCIQTGRNGTLHFKLALEDLEAAESYEELQFTYRPQLDEDRDSDLIEFLPDYLTEEITFPRHQASKFYARVIKSLMERVEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVF7</accession>
    <name>A0A2T4BVF7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1078238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVF7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="24064" checksum="FA2CB6FA7EFB8AD9" modified="2018-07-18" version="1">MLWVYFAPRRQCVQRSASYLMLLGGSIGYLPLTTMMMAFRRPVDGLHYRTSVFRIRVSRCRPGGNSTSIHVLLRGNSEYSKYATQYIYIQRIGHCQQIRCWQKKRDRSNLSSRFPFRLLSGKEAKEAKSMCNQASPTVGRLQCIPQDSSSTFDIDSLGIGRDARGTSCCRFESAEQEDGQHTASRGGLATISAMETNLLVMNLGDDGSAELERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVX4</accession>
    <name>A0A2T4BVX4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1063060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVX4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="213" mass="23013" checksum="573AC178FD45529B" modified="2018-07-18" version="1">MWAGTFPSPYTAVRIKGQGMIFFSSSSTGPMPHCRVTVELLWFGPFGLRNVRVDSPSSPDLVGLRPRATPPCWADLRSGGGRPPPVTPLEAYDQHSPVKYHAISLVARVCCFSCHIAARLDNDTRVADGASRISRRPLSLSFGAHSVGTLGPLHSNGHWPLSRLLLTHCLPDGSIDKKIRAELGQVKERPRPRRNPALPSAGIVATAIVRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVX5</accession>
    <name>A0A2T4BVX5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1063395</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVX5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVX5"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB73462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="95" mass="10472" checksum="66F4EFB37D592609" modified="2018-07-18" version="1">MSFLGIGRPQPTSEQKIAAVEGEMRMMADTYNRLQKTCQKKCVPTDYREGELNKGESVCLDRCTAKFLDTSMKISEIMQQQGQAMGGGPQAGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW19</accession>
    <name>A0A2T4BW19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1063918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW19"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="160" mass="17594" checksum="F1CAFB9CCDE60A60" modified="2018-07-18" version="1">MKSARRLSCASNHMPRNDAISHFGVCIPAPKHPPVFQTSQHTPTSVQFSPAINVPVPPRKRTSGPGVPSKATKTQRKAHLRTPISCQATSTSSNRSALLLHHQKKSRFEGGGGDDIFCCRDPRLGPPSCRSQLDRQKGSLWGNESDQRALVLDRGKWPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW36</accession>
    <name>A0A2T4BW36_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1424820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW36"/>
    <dbReference type="STRING" id="983965.A0A2T4BW36"/>
    <dbReference type="OrthoDB" id="5325022at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27909" checksum="2F296B9FFC51BB0B" modified="2018-07-18" version="1">MDASERPRGQEHIPEYPKLWIWMRVFQLVVGLAVLFLSIHALEGFRVLMDLSIVMIVISAASVGLTIWLIVAQFSSPRAFRYWITLVLDFLLFVAWTVSGSILVSHTSALVAQRGVSGNRFDHPEHEQQHQHPLHESHVSTFYAIAGLACLEFSLFCSSWIIDTVVIRRHRQIGLPSKPLKKRASLAERQQQQAKPIPVSPPQKPRAKPTLAERVEMLFKGQQEASASEGVGFEGSGGGGHGGRNESTDGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWD6</accession>
    <name>A0A2T4BWD6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_135778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWD6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="16972" checksum="CF938AEF468F6184" modified="2018-07-18" version="1">MSLKSVKSTHVESCRSLASGPSIALGVNSFAIAICRSRLANQDIRCKTINLSNFISFLCPSFRLHSPPSIFMPFSLPLDARFLEVQYRLMRRFFQCKSGVAFEHVLNLRIPSNMGAAFGPDITVSRPGTVLVSLLLVSITSGFLRNRVLSYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWT0</accession>
    <name>A0A2T4BWT0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_120611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWT0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="178" mass="19562" checksum="82BD9E50C66EB5C1" modified="2018-07-18" version="1">MGRGRVRPCHTNGQLPKTGPLGEAIQSRQSEGGIENCFFAAVAWRVGSEAPMPRYTVSSNQLSPMDGVLGLMSLYARAPDPWPLSIYTRWPPDGHGLLRSLQLSRESSCKQDQRDTAEDTIYNLGSRSVHLLADCTCSPTCSTPSPSPSLLTLHRVFCSLHALVRVDRTTKAHHLDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWT5</accession>
    <name>A0A2T4BWT5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1471822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWT5"/>
    <dbReference type="STRING" id="983965.A0A2T4BWT5"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF6">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB73779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="361" mass="38057" checksum="DEF877CD36A4912C" modified="2018-07-18" version="1">MVNIPRTQTAATVPKLGGGVVFDHNYPVPQPKHNEVLAKVLYSGVCQSDLHTQAGVAASADGTPITNVKLPHVGGHEGIGRIIALGPGVDEDIKVGTYVGIRFASRICRRCNFCLAGKEQHCIKSTNHLHHEDGSFQEYIALDAGYLTILPDDIDPVVTGPVLCAGLTTYKAVKNCNVKAGDSVVVVGAGGGLGHLAVQYAQAQGAIVYAVDGGAEKGEFLKSLGVTDYVDFTTTPNLTEKIRDITNGGADSVIVTAANVKAFSQAADMLAVGGTLSCVGIPAERGYLETPISTIVIKGLHITGNLVGSLKECLEAVDLVRRGIVKPKVTVRPFEDLPKIYDELERGDVLGRIVLKIAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX34</accession>
    <name>A0A2T4BX34_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC-transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1381903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BX34"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="824"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="939"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="968"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="60"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="390"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="826"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1146"/>
            <end position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB73890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1406" mass="152536" checksum="C0389765D07E3BA6" modified="2018-07-18" version="1">MAAKDKETASSPAPTNASTLILDIDSSTSCQATGPESKPQRSSFKHLFSFTTWDHTASLLAALVASAAIAAIKSLLSVVLGKTFDAVSDFGAGHGSGSETLHNVAHWTLILLGMGIADWGASTALLLLWIIFGELQANSARKTIFESLLSKKMSWFDSLDQGISSLLVRIQTQSSQTRELQLATSQVLGLLVTDLIVSIASLAIAFTYSWKLTLVLIATLPISIVIMSLATRRLDPAIQGQKLHQETASKYATSSIKAIEIVKIFNGGDHELRQYYEAVKLASKQYLIQAKCNCFQMGYVAFWVIGMFVAAFWYGTVLVDQGLSPGHVITTFFATLSAFQGIEALLPHWLVLAKGMSAGSFLSSLANKRDDETANAQSGQTRPAACAGNVDLVDVTFTYPSNPTKTVLNRSSLSFLPGQLTFIVGRSGSGKSTIGNLIAQFYDPSSGIVCLDGHPLTSLDANWVRSNITFIQQLSVLFDDSVFNNVAVGLGDPESVSKEAVSSACEFALLQSTISSLPQGLETRIGPNGIQLSGGQTQRLALARARIRDPTVLILDEVTSSLDQINRGLVIDAIREWRRGKTTVIITHDVDQIEDDDYIYVMENASLVQQGLRKELDTLSTGPFAILTRLAPVEARPPIPTRTERTASGLLNSNNRTISTISERSFHKTLSMSSSLHKELNNDMQDPARNRFSQYKALGAGTAMALEMRKKQIWEGFEVVEGPREIARSGSFCEAEKRKSSNTVDEVYDPPRRCSAPEPEDLLYVFGKAERREGIRGLRLAATREPAPTMNEGIITKKGSSKPRTLLSTLGTVWPTLAASDRAIFVVGIVVCIISAASTPIFSFCLSQLFGVLWLPDNRAAEAKKWALYLMATGIIDGTSTGFGHYMLERTGQSWVNALRMKALKNILQQPKSWFDKETNSASRINECLDRDSEETRNIVGRFIPIFISAFGMIAVSVIWALTVSWKLTLVSLAPLPLIAGAVKGYTAMSEKWETRCNQGATDAGALLNETFVNIRVVRALNLEKYFGAKYEKQMAHVLGLGKRRAGYTCVLFGLYESMSFPLTALVFYYATVLLTRNDGVTLTQMLQVINLLLFSIGMSAGALDGMPQLTMAQATATRLLGYVTMPVEPEEQGESGIKISNPLPIQLKTVEFAYSQSPNAQVLRGISFDITPESCTAIVGSSGSGKSTIISLLMGLYRPSKDTASSLTYAGVPSSALNTHHLRSTMAYVSQTPRLFPTSILENIAYGLAPTSPLRKTTNIHAAAKAANIHEFIVSLPQGYATPVGEGGIALSGGQAQRLSIARALARQPRLLVLDEPTSALDAECSGMIRETISELVGRARTTGQGEMAIVMVTHTPEMMRVCDNIVVIDGGVKVEEGTYEELMSARGAFRHLVSKGEWHGGEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYE0</accession>
    <name>A0A2T4BYE0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1337649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYE0"/>
    <dbReference type="STRING" id="983965.A0A2T4BYE0"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000006">
        <property type="entry name" value="Heat shock factor binding 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8160" checksum="6972F9F4811B7134" modified="2018-07-18" version="1">MASNRDSIASNPAPANDDSSADVTAAVEELLNSLSNKFAGVSSEIFAKMDEMSRRLDNLEAALVESKNKEAGSAPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYJ4</accession>
    <name>A0A2T4BYJ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1047641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYJ4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015437838" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13471" checksum="4F7E8D1124023830" modified="2018-07-18" version="1">MLLLLLLLLPPRNALGKRDEKRCSRPKLMLVQACFAHPLQARRCPAKLSARLKFGGSPPQPNETSRVAAAVQKRETDEERIAMFLLRRARQVAKTRESDMSKKRRECMSYFVVSACCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYK0</accession>
    <name>A0A2T4BYK0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylglutamate kinase</fullName>
            <ecNumber evidence="2">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1403693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="2"/>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74334.1"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
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    </dbReference>
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        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
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        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB74334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="533" mass="58300" checksum="A049FE19CA0EBAFA" modified="2018-07-18" version="1">MLSATSAALRAGARRGAPRAAAAAAAGASAPNVVRGSGPSLGRGLAGRRGLSSTRALASLPTRDRTREIVAQTVSSIGSKREGQQYLKLFTSVESQKFAVIKVGGAILTEYIDELCRSLLFLYELGLYPVIVHGAGPQLNRLLEEAGVEPQFEEGIRVTDAKTLGVARKLFLEENLRLVDRLDSLGVATRSISGVFMADYLDKEKWQYVGKITKVNKEAIEKSIEAGYIPVLTSMAESEDGRLLNVNADVAAAELARALEPLKVVYLSEKGGLFDGEGEKISHINLDEEFDNLMSQPWCRYGTRLKIKEIKELLDTLPRTSSVAIIHPSDLQKELFTDSGAGTLIRRGDKIQKVSSVSDFEDLDKIKEALIRDREGLDAEATVDRFIDFLRENPFTAYYDDALQCVAIVIPAGKDRPMATLATLAITKSGWLTNVAENVFAAIKKDHPSLVWTVSENDENLTWFFEKADGSFNRNGSVLFYYGCDLRSDALAPVYDDFVSHGRAMLGDSNLEARLRRAAQAASQALRDSQGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYQ8</accession>
    <name>A0A2T4BYQ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_116746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYQ8"/>
    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="209" mass="23635" checksum="67109BC0E8EF59F6" modified="2018-07-18" version="1">MPHLKSEVIDRTSLSDWQRELSLKLPILGWTWKRITGIYTKRKALIWSNTTGLRAGSEIPNTLLELGTRHNFHLDIRPFFFFFFFCLVSLSPFYPHSYFLHLSSLLFSFSLSRLTGLTFSLPFFSLNCIDYKGMPDSLFFPQKLGESGHAEACSSSSLLFPFPSLLFSFTCIYMTTSRAAGCSSSLGEYDNGKGFLPGVTMAVILFRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYU5</accession>
    <name>A0A2T4BYU5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-classical secretion pathway, nce2 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1440616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="179" mass="19628" checksum="F913D740B49E8DC1" modified="2018-07-18" version="1">MSNLFKIALRGIALVWTLLITALIGNVIASNVNGHMVTVNFTMFVAALSWVALLYGLFAIFIESIAIPSALLILDGLATLFTFICAIVLAAELRAPNCGNISGQHLPSHWIGFGSHHDERRCREIQASTAFMWFLWACFSLILFITWRDARSSGFTGSMRTSRSSRSSRPAMSQVGSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZA6</accession>
    <name>A0A2T4BZA6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_56576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZA6"/>
    <dbReference type="STRING" id="983965.A0A2T4BZA6"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="188"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="315"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB74565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="428" mass="46914" checksum="4822D29132DC816E" modified="2018-07-18" version="1">MGAQDGDGGNTVPDITAGQKMVSAMSGSLLTSLLVTPLDVVRVRLQSQSSTKAATTTVRTVDFSKLMRTTTSLTPVQSTELGVTACCREVFFAGGSIDYCLAVPKMEGIAAPSGSSAAAADCAVEEVQRKTYNSTIDGLRKIARNEGFTTLWRGLSPTLVMTIPANIIYFTGYDWLRFNPVSPFSGFSDDYAPLLAGSAARLVAATAVSPIELIRTRMQAAHGGSTTNHLVETFNGIRSMVASHGYTSLWRGLTLTLWRDVPFSGLYWWGYESIRSRLTDLREERQGRPLTRGNLDGLERTKARRRSQSREKHTETFLDSFTAGAISGALASILTMPFDVGKTRTQIYHNSPHRVAGAAPAPEEQNMIRLLWHIFKTEGFPGLWRGWIPRTLKVAPACAIMISSYEVGKRAFRGINERAREESFARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZB9</accession>
    <name>A0A2T4BZB9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1393016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZB9"/>
    <dbReference type="STRING" id="983965.A0A2T4BZB9"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="300" mass="31565" checksum="144A93CBE72349DA" modified="2018-07-18" version="1">MAPPSSSSPPPSSPSSTQAETPLPSYAAYKFFTVTSPAPYVAHVQIQRPDKLNAFSEAMWLEFGRVFGQLSRDADVRAVVLTGAGERAFTAGLDVQAAAQDGNLTGTGDAARRAKALRAQIEEFQGSIGAMEKCEKPVICAMHGISLGLAIDIACCADIRICASDTRFAVKEVDIGLAADIGTLARLPKLVGSTSWVKEVCLTARDFSAQEALAVGFVSQVHEGKGATVRAAVGLAAALAGKSPVAVQGTKELLNHARDHGVAESLRYTQLWNSVALQGEDFPAAILSVLKKQRPTFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZE2</accession>
    <name>A0A2T4BZE2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1471309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZE2"/>
    <dbReference type="STRING" id="983965.A0A2T4BZE2"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000280">
        <property type="entry name" value="Glycoside hydrolase family 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039743">
        <property type="entry name" value="6GAL/EXGAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767:SF1">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015680763" evidence="1">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="479" mass="52349" checksum="C30BBE510E1672F6" modified="2018-07-18" version="1">MALTFLSTLALSLLSQGGRADTTLSIDPNSNWGTWEGWGVSLAWWAKAFGNRDDLASVFFSRNNQAINGQTLPGLGFNIVRYNAGACSNNSYDGATMVVSPNIKPSRQMDGFWLDWASTDPSSSSWNWNVDANQRAMLQKAKANGANIFELFSNSPMWWMCNNHNPSGSGATDNLQSWNYQNHAVYLANIAQHAKQSWGVEFQSVEAFNEPSSSWWTADGTQEGCHFGVSTMATVIGYLNTELSSRGLSSFVASSDETSYDLAISTWQGFNSSVRNIVKRINVHGYQGSGGRRDTLYSLASQSGKRLWNSEYGDSDASGKSMYQNLLLDFTWLHPTAWVYWQAIDGAGWGLIVGDNDRLTLSSASTKYFVLAQLTRHIRPGMQILSTPDDNTAVAYDAGSQKLVIVAANWGSAQTITFDLSRARTAGSNGATVPRWSTQTGGGDQYRSFTDTKISNGRFSASFSSGQVQTFEVSGVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZP1</accession>
    <name>A0A2T4BZP1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF676-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1403284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZP1"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="439" mass="49573" checksum="77F1F796299E167B" modified="2018-07-18" version="1">MDFAGGSSKADHLCVLVHGLWGNPNHMNNIAKTLRAQHSPDELYLLLAKRNSGSFTYDGIELGGERVCAEIIEELRMIENNGGKIKKLSVVGYSLGGLVSRYAVGLLYAKGILDTLECVNFATFATPHLGVRTPLKGWHNHMWNVLGARTLSMSGSQLFIIDNFRDTGRPLLSVMADPQSIFMLGLQKFRRHTLYSNIVNDRSAVYYTTCIEKTDPYSDIDRIKVNYLKSDVEGVLLDAAHPFSPRPKVPAPVTLSSLTETGIRWMRGIPFMITVSVLVPIGVVAYLINSVFQTIRSTKRIRLHEGGMAGINVAEYRVPILIKELREEVEHAYEALNSSQNQEYLADEDEDEETGMNAEDRSTMARERRLSIPTQPTLALAPCQFEMIRSLNSLKWRKYPVWIQNDRHTHAAIIVRYEKKTFDEGWVVLRHFAGEEFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZQ7</accession>
    <name>A0A2T4BZQ7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_104330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZQ7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="220" mass="24866" checksum="7892602A1D1D3151" modified="2018-07-18" version="1">MQQCSLVRSLYSSIRAERRIQGRGIDPPGCLCSLDVPPGGAWNGRQQRVSSASGIRQTKDHGQVPPTRSLRRSSSRQMRESRARERRHAGGLCTPWDGSRMGDQGRLVRMLANDGCWIMQGPERYQVRARREMFGSVSRVFFLPPDNRKHSADVRLVLAQRPWLCLFLAQSRFRDPLLPGISALERTRISSSSSSQIKRHGEKGRRGGRKDQTAVSELMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZZ6</accession>
    <name>A0A2T4BZZ6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1380521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZZ6"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB74890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="505" mass="56468" checksum="1BCA7DA561AED567" modified="2018-07-18" version="1">MANSGTATEHRLGAWEALKLYRKGAFWSMFISLSIIMRAYDIEISGNFFALPAFQRHFGVDYGPDHGGYQIPARWQVAMGMGSLVGQIVGAYLVSFPMERFGRKKTFAVCLVLTAILTFMQFFANTIGVLTASQYLSGIVWGGYCVIATTYASEVLPLSLRGFLTGYINLCYVMGQFIQTGVTRGFINRPDQWAYKIPFAIQWAWPVILLAGLPFAPESPWWLVRQNKMEKAERSLEQLVQKNSGINTKETLAMMVKTDLLERELEIGTTYADCWKGVNRRRMEICILLFVIQNFSGNPVGFATYFFEQIGLDNVQAFDMGVGLNGVGFVGTCLSAIPLIYLGRRPAYIFGLSFMVATLFVVALLTFAHDYTTNDSYRWAQATLLIILQFVWQATLGPLTYVVVCETPSTKLRSKTIAIATMIDALTGLVTSVIGPYLLNPGAAGAGAKIEFLYGGISVFSLIWTIFRMPETKGRTYEELDIMFERNVPARKFATYKFEDEDLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1N9</accession>
    <name>A0A2T4C1N9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1402018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1N9"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015729128" evidence="1">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="419" mass="44228" checksum="DF6D09F5D029C42D" modified="2018-07-18" version="1">MNPLSLSLAVLLAASPLAQASPARGCRASCNAADSLIRLLRAPSNLPEALPFCSNYLDLPASTITIETVTPTTTAYSTIFTDVSPTVTISTEHVDTVVPTRIVTVTNVHTETSLMTDTSFTTEFVTVTAAAVQQRAISTPLSQQITQSYGSSRISSGCACLTIPITTTSVTVTAQTVTVTETNQLTTTAPEATQTLTSYRTTTLPEVVETTTVDSTILVPATTTQVSVVTHTVTATAAASATGYFYIRNVRPASDNFFSGNFLVNRDFSSTNKAQAATISGSNTTAPRMGLTPEGYLTIMQSRVATSAATGTEGQTWVAFAHNNMNSEVLTFDKLANIQACSTCEPLTFEVSQESDGSYINFVNEGSRAIYICGPGASASFYAFWISLTGPPTSSCFMQRIYKSKEGVAGPTFGTPTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2E4</accession>
    <name>A0A2T4C2E4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1402257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2E4"/>
    <dbReference type="STRING" id="983965.A0A2T4C2E4"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB75733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="286" mass="31350" checksum="AAD22371D3978902" modified="2018-07-18" version="1">MASITTNASIASFGGRFLKLTHTSALTGGPMNFTLFLPAGISASSPAPLLIYLSGLTCTPDNVTEKGFLQAHAAPLKLALLYPDTSPRGSDHPGEHESWDFGSGASFYVDATREPWAKNYRMESYITQELPEVVFSNFKELDPKRVSIAGHSMGGHGALTLYLKNPGKYQSVSAWSPISNPSACPWGEKAFSGYLGGDREEWKKHDATELVKHWKGPLNALIDVGTADNFYKQRQLLPENFAEAAKAAGVEGLELRYQEGYDHSYFFISTFGEDHIKHHAKHLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2J7</accession>
    <name>A0A2T4C2J7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1439451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2J7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2J7"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB75796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="90" mass="9831" checksum="39ECA72A792CD6D1" modified="2018-07-18" version="1">MSETAAPRSPSAISRPVSEALLNEKWDRCLSNLLVKSTLGLGFGVVFSVLLFKRRAWPAYLGAGFGAGRAYEECNFNLKQAARDLKKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C394</accession>
    <name>A0A2T4C394_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1438810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4C394"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="198"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="337"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="416" mass="43791" checksum="5045F73E0750CBE9" modified="2018-07-18" version="1">MSTTPPPPTQSAKRPLEEPSSPSRATDQPEAKRPALDKASKSDEETEKLDIPPELPVESEEEQNGEDNANGVAGTESSVTATETGTDVKATPTVAISTASSSAVAASAAAHDESSWIHIRAVISSPEAATIIGKGGENVSNIRKMSNAKCTVSDYQKGAVERILTVSGIVDAVAKAFGLIIRTLNNEPLTEASTASSKTYPLRLLIPHILIGSIIGKGGSRIREIQEASGARLNASDSCLPMSSERSLVVMGVADAVHIATYYERRPHHMPPAPYPQPYAHGAPHGTPAMPMQYGAGQPAAYGAAAPHVQPHMAPHTGPQAHGAPQGQPMHAGMPGGPITQQIYIPNDMVGAIIGKGGQKINEIRQMSGSVIKINEPQDNSNERLVTITGTEECNRMALYMLYSRLGETQNRSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3C1</accession>
    <name>A0A2T4C3C1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1245127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3C1"/>
    <dbReference type="STRING" id="983965.A0A2T4C3C1"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="378" mass="41332" checksum="368CCEDA414EB4E9" modified="2018-07-18" version="1">MSSDQVPVWLDCDPGHDDAFAILLAAHHPRINLLGISTVFGNSSLEHTTHNAASLLTAFGKHNDIPLYVGLDRPLERPPLHAPTDIHGDSGLDGTELLPAPKCAPKPEPAIEAMAAALRAQPAGTAWIVATGTVTNVGALFRRYPELVAHIKGLSIMGGSIGGGFSDAPLGRVDGKERIGNTTPYAEFNVFVDPEAAAELFENRELAAKMYMVPLDLSHQVLATERVRELLLYGKDVPQEKTGKGKTELRTMLVELLYFFAKTYAHVFGITAGPPLHDPLAMAFVLLGTPDEIPFYDWDEKKSQPPKHHERFNVTVITEGTTEEAKRGEKQTGRTIAKALPPGEPGVMIPRGVDVERFWQVIEECMERADETNRRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C472</accession>
    <name>A0A2T4C472_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1332937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C472"/>
    <dbReference type="STRING" id="983965.A0A2T4C472"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="439"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="522" mass="58200" checksum="FEC3A52E8D7A949B" modified="2018-07-18" version="1">MEESIHHFVAITGASVDVARGYLELTGGDNQRAIELFFESPDLVGDGVARPAATTSSSRSRSASRRVNIGREDASGVIHISDDDEGDADMDYDDNDFEDHDDDERAAVAQAAALAQEEEDAAMAKRLQEEMYQESGPSGDVRAPIARTTETLVAPDPSWGEDDSSAILEQLRRRRPMPPPNRGPFGHRIWGDDADRAEPSSANGTSSHARRLEDLFRPPYELISRLTWDEARALGKEDKKWIMVNLQDMSDFNCQMLNRDIWKDRAVSELVKENFIFMQLDKDYPEAEEYLTFYFPNQGHENPDNYPHVSIVDPRTGEQVKVWSGRPFPSATEFHAEVAEFLDRYSLAANSKNPVARSAARKPQVIDVDRMTEEEMLEMALKNSLAGAEASGSGAGSTPSVHDPDALTKEPQQSGGQEAAQGPFAQISSTNPHTEPANDPAATTRIQFRHPDGRIIRRFSLRDPVRRIYEWLKAEPLEGKENVPFELKTMPQGQDLIELLDSTIEEAGLKQGTVMIEFVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4K3</accession>
    <name>A0A2T4C4K3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_4951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4K3"/>
    <dbReference type="STRING" id="983965.A0A2T4C4K3"/>
    <dbReference type="OrthoDB" id="5137810at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="800" mass="86881" checksum="DEBD261AEE12058C" modified="2018-07-18" version="1">MTGRSASSDGTFYFQAWNTGKTVTAESWVQNKGLADFVEQNLSAEGKQWLFVKGCVPTQELTGLAIPYSIAVKLRAAKSGQDPKDAVKALFKFRNKEFPDLARVYFKTRLHKSLDFFNAFSEGAESDPLVADFNVTKSSKRLKDKVRSAVKFMKKDVWGDLKNGLIGGMSSKSSEFKAARFIAKRGQGMYWAFEKSEIGVYGDIGEGDVVNICLDFSDPTLNPHALPTAPLQSPFSMSDLGCAPPQPGLSSVPLQPDLSTAAVQPQVLPPRPRTDSDASDLTVGSTVASASDASSMVSVETAQSSIYGEDASELHHHHAKDGHSELLPVPEEEELVLTSPADTESSPVVNADVEVPAVAAPADSSAASCQDITTESMEVTDVTVTGVTDMTDITDVTDITEVFNATTAPAAVTPTSSGIVATRRRMNCVLSPQKTKTAYFVVQNAGNWLKYLTANHAQSAQQLRSTLFDSPVILAATLSPVQALTPDGMMRVYFMSQARKQLEDGAPRNERSRAGRTRKGKSVREWIVGSAKMSTRTFKHLGQQLGKRNARLLPAASAPVRKVDSVVGPNNRLIEMTPAPGVPQAILVTTPHPVEDVREGDIVQEERDDGFVHIESNIVNRPVEVVTDRDGGAEKKGKGERKRRPKGKGKSRAETVRIRKPTKMDATNTHTGTRADVITDFTVDADSAPPRKPSKVYTPPFSRKAWRDVEPQEPQVVYDVMSGYDFLQVEDVQVFSFSTSSHDMMLRTSPPPAPVAPATPAVVEEGEGLGIWSPPAVVGIFSWMWDHLSPVSWLRTSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4N2</accession>
    <name>A0A2T4C4N2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Probable kinetochore protein nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M440DRAFT_1333928</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4N2"/>
    <dbReference type="STRING" id="983965.A0A2T4C4N2"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000003">
        <property type="entry name" value="Probable kinetochore protein nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="18">
        <location>
            <begin position="281"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="166"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PTB76488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="462" mass="54048" checksum="7A675B6B8ADA10C4" modified="2018-07-18" version="1">MAYNPRVSIIPASQQQSRSRKKEEEADAFMRLPDREIVGCITDIGINFTIADLQKPNPAHVQQIFEWFAELLLNATRETVEPAMRAAAEDVCGEFADVISPDTRNLMGFFVSLRRLLVECGIQDFSFNDLYKPTYERLVKIFSYLINFVRFRESQTSVIDEHYNKAESIKTRIQTLYAENQEHESRLEDMKNNRQAMEAQVREKTMRNEELKRRLLELRRNQEKVAARLEEAKQKKGELTTVLEQKTQEKITLKQESAKLRPYVLQSPSALQQNLTELRDILNNDKARIDALDRRARALQTSADSFGVVTTDVASCIKVLEEIAMEMAKEEEEMAKNTKQREALSERGNNAREVERAEQMLKRQLAKWMERTEKLREQSNQKAQDAKEKMHELRATHKRLTEELTDKGKEMEIRRVRIEQTEKKMLDLKENIENEVHAAYDEYLKMEAHIKLYINEMEQTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4X4</accession>
    <name>A0A2T4C4X4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1331655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4X4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4X4"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB76603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="62" mass="6963" checksum="19BF0DE736A8E81B" modified="2018-07-18" version="1">MAIAPITGMLRRQLILDLGVGLGAGFVMANWYWYGYHMPRTNGRDAYYAKKEAERAAAKQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C522</accession>
    <name>A0A2T4C522_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1456284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C522"/>
    <dbReference type="STRING" id="983965.A0A2T4C522"/>
    <dbReference type="OrthoDB" id="5244050at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="686" mass="75188" checksum="792A6865EF7D2BC8" modified="2018-07-18" version="1">MKKFNFSRPARKKPQEPPPPAIPSTMPMSKAHKILGSTPLNIDAPYHDPKLPTVSVGMYDNKALDEPDMHMPSERRRNDRQPSPSNRLGALTDSIGFGAKNLPGTLKKAQSSSTIKSWHDKSKHSRSLSRQASIPVMNSSYSPNTQAAPNAEESPKSRRKPPRLDSIVIAPPLRIPGLDSGGTIHHGIPGDSVTTPVAAPYSASSHRQSDLRGMFKRRTKDSFRSFMTDSTPQSAVEGRRMTSHASENRLSTLYNHYEQMTFRDAEVEPGLMSGADNKKDAAGGQGEPQWRESQARHNLDWLHKPRKRMSPSPSRLNPPLRDGSRTSSPKPSVGSTNSTGSGMTSQNGYGAEDSHLTTVLPARRPSQAELDRQKALAQLTSGSSSSLRRGSVATSSGQTDNDIPLPPSPASVNRYLRSARSSVDDSASQGCVMTLTRQEEMLISALRKKTQAMREKSQLASASNPRSDTSSTRRHVSNPSRVETDSMLDFDFPAPPSHSTKSRQSVASSFMSTPITEHPDGEDDNYRAPSRLTADTGSERASFVSSIRGPEDFAEAQDVLVYLDQGKHSSGQWSHVGSDGQPVEEAVLSSGFQSVPWEFSEENRPSKAKARVPLRHQNQADYMSPSKLTRLSEDGNEDMPRPDSPISNETFPQPQQPRRAAMNTARLSAVGFVRRDPELGWWGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C537</accession>
    <name>A0A2T4C537_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1401031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C537"/>
    <dbReference type="STRING" id="983965.A0A2T4C537"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="325" mass="36542" checksum="D63CC830B7E74BAD" modified="2018-07-18" version="1">MVLHNPNNWHWVNKDASAWTKDWFGENLTKLEAENGDVKARITKVQSMTGDVDVSQRKGKVITIFDVKLVLEYSGSTADIDEVSGNITIPEIAHDTEEDDYVFEIDIFSESKEKQPVKDLVRSKLVPQLRKEFQKLAGALITEHAKDIQHAPGSNPSSGFSTPRTLPQAAPKAGTQTPTSHTSSSGVVNTVTVRDDQEFRTTAEELYQTFVDPQRLAAFTRSPPKVFEGAKPGGKFELFDGNVSGEYLELEKPKKIVQSWRLNQWPAGHYSKLNIEFDQNDVDHVTVMRVTWEGVPVGQEDVTRRNWGEYYVKSIKQTFGFGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5B6</accession>
    <name>A0A2T4C5B6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1430519</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5B6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5B6"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="C:Dom34-Hbs1 complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:translation elongation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="G_TR_CS"/>
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    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="414"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="203"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="355"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB76722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="824" mass="89656" checksum="9632648645045A90" modified="2018-07-18" version="1">MAPQDYDDDDFVDQYDEVLGEEEDEMSPEDKVAMQKGTEEVRKALGEEASKVTVAQIQEALWHYYYDVDKSVAYLKRTFIAPPPKPAPKAAQKPAPKKVPEGKNGALSLLASGDPFVRPLGEDDEYTPTIYDIPPLARAFPILEKPRIPPNFFDDMPWLNIPRDRETMFVEPLRPRGGLLGGTGSAPKVSKLQALAAMRKRKLEEKKAQESPESLEGEVTKLALSDANKETMGIKSKLQRRNSSTGSSTPQEQPQEQVQNIPTAFTDDSLGERASSPIATESKADDSIPEAPKPAMSRSHAPSAFAQALFEPDSEAEQRHRRDVFAMPYTQSSLFVASVFSEPSPDDIVLAARAKAGKKAPATPKTPKKSQKNEESSKEGGLAGSVANLKVTDSPPPKSKGIDVIKEFEQSASKKHASFVVVGHVDAGKSTLMGRLLLELKLVQERTVDKYRRQAEKVGKTSFALAWVFDQRSEERDRGVTIDIATNHFETESTNFTILDAPGHRDFVPNMIAGASQADFAVLVIDASTGAYEKGLKGQTKEHVLLLRSLGVQRIVVAVNKLEAVGWSQDRFQEISEEISGFLTGLGFQEKSIKFIPISGLNGDNIVKRSEDEACSWYTGPTLIEGLEASVPPTVRALQKPFRMAIAEIFRSQQGTTTLAGRIDSGTIQVGDALLVQPSGESAHIRSIMLDTETKDWAVAGQNVSIGLTGIDPVHVKVGDIVCHTKDPINVGDTFTMKAMAFAHLMPMPVDLHRGRLHAAGQIQSIAALLDKATGEVVKKKPKVVQPGAVARVLIKLDTKVPLEAGQRVVIRTGGETIAAGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5J3</accession>
    <name>A0A2T4C5J3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1236266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5J3"/>
    <dbReference type="STRING" id="983965.A0A2T4C5J3"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48219:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48219">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB76839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="165" mass="17574" checksum="B61F67331A05CFEA" modified="2018-07-18" version="1">MILISIRGHDCIMCNWFYLLETVILHYERIWKDEGSGADRDGSFWRPVAPAGYVALGDVASGAGWDAAPSVDDVWCVRGDLVTRGGFRPESAWDDKGSGAASGRLGVGGGCWRAAERLRGCQLGAVCGRGRGGVGGRDTRVFVGPMRAVAGYDEPDASLALVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5J9</accession>
    <name>A0A2T4C5J9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1236293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5J9"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8919" checksum="B62C935A7199A73C" modified="2018-07-18" version="1">MPARCCATNRFRNSASESTVRKKKGNRISARKDPSTSAPYVLAAKPHASQRSRRQLLVSWFASVFPFYHFSNFGTPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5K6</accession>
    <name>A0A2T4C5K6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1236735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5K6"/>
    <dbReference type="STRING" id="983965.A0A2T4C5K6"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB76857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="669" mass="74728" checksum="B2104963CAB4F0C4" modified="2018-07-18" version="1">MVLKKHELEGKLGEESLLIKSGVLRDENPLDTSAEFHDFLLACRRGDLKKCQELIGMGVNINGKDKFDYTPLIIASLCGHYELVQLLLESGALAERNTFQGERCIYNALNDRIRNLLLQYDFSKSSDPYVYWSSHISSLLARSSPQTADISLDADTRSFRLHKFLLASRTPYFRRKLQSNPETSSWKLSSTIPVEAFQIAVRYIYLGEVPRDLAPPGSAATEEDVAKGLDRISKLLEIEQLWEAILVGNDRRLARQRYQDEVARALGQVTDFFQQSVLAHKMVVDTDRVDEVRWRHDNSIFADVLLRADEPSAEDTDGILLAADATSSSAGIPIGPSHEAPAPAAAAESNGGIKKTRKSVLYPAHKAMLIRSEYFDKMFSGDFVESQKSDHLHVITVDCSPPVLELILSFLYTENASCPLEHALDLLYAADMLFLDSLKNKAAIAISTLGSGTANALVDRTHNSNNTDTPKTKEEDSPQVEDPEHEQVVEVEPINIYDVIHAAWDLRVQRLEEFAARYLAHRLEDYIDEPDFHELIRESAERIRKREETDTIELLDDIRYYLSERFRLRFEDAGLEEMMDEEGEIGAEVVAALVNGSSGDVAAVGDRKSEKHGGDGGERNGDKGGEEGEEGVRTLNGEAAEDEFASDAINYQILLHKIDAMLEGLKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5X8</accession>
    <name>A0A2T4C5X8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1332710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5X8"/>
    <dbReference type="STRING" id="983965.A0A2T4C5X8"/>
    <dbReference type="OrthoDB" id="5226586at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="327" mass="36645" checksum="430B4E7A67636628" modified="2018-07-18" version="1">MDLDTIAIAEGSAGELPRDISPSSSPSSCRYSLDSRSSVSTKPSSRGSSPATKKDTNDGARGRSRRTLQPVTPSWNHLLHPRSYEEIYAERAYLTASLQAYSLRAIEMIHQYSLIEEELQARDHIGKERRKLRKQMSFIKVKLSEASRQEKAIVLRLSELHMEQLGRDAWDQVQQRRVYYSKFPPRMAKMPSDLPEKPLNADSKEFVPSAIHFGNSPPSRARSCVSEAESAALDTVVEGIEGEENDGESLDGPETPAAEEAKTRSEGDLQGDELCNHGLQYTYRACEETSESQLRPLDERHKLSVRSERRKSLPNLCSVWPEAKGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6L7</accession>
    <name>A0A2T4C6L7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1206201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6L7"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="638"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="746" mass="81268" checksum="1DA3BA7A6BA97D56" modified="2018-07-18" version="1">MAPSFLSLRDLRRRSKASFRTETSTDASSDGALSHDTHDTAPSSGSSTPPSVAQQSDPALNLQIKDSNGSGQSPTQAPTRPMIVPSGNSSRYSVSGMSGLGSPSPNGRTNLPVSQYAPRVQNISDGAWVYQKVLLLHGAVGESQQNHLDGTLTISRQDDAFPPTSWPVCESNFKALVYLQPGPNKIRLEFSSPKLANSSSSNPIHVSYFTFHMVPSLNAPPLQLAIVLGKDSPGTFDATPSRAEREGNGLDTAVKKFRMAAYLWQAFTAEQMWRHKLGRRTFRFEEEWTSGSANYRDRESGTMRSEARVHIIRSDKTVAELRDLNKAQQYDKATDKNALFDIAASAVKKQLNPLPGQTQYVAVLLLDAHWDKDAKTIRGHAALGGGSGDLQLGIFGSHCLHSYPSCFEEVVPAFTDCTPTDTAHVANDCNEAGSSWEAANIGIGAHLHEVGHLFGCPHQEGGIMLRDYVVLNRSFVAREAYSTRTKSKGGLALQADECGWHRLDCLRFRAHPAFRLPNDPPMNPDESVQAFAIDGGNVLAVAQTGIAFIEIYGEGDDVCRSWIEYMPDTNTPIQRQVTLIEQDLRARLPEAKRKGRVRVSIKSHGGGSLDIDDFKAFASKASSVKLPGGKLAFRCKSLGHSKMQGSEPHEVIFTSAVKQDRVMSRVIVYHGRALDGLEFVYDDNSTQLFGKRGGKAGGDTFEIDVRRGEYLTGFVVRAGFWIDGIQLLTSLGRKSAMFGNAHGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6L9</accession>
    <name>A0A2T4C6L9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1421022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6L9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6L9"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="517"/>
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        </location>
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            <begin position="789"/>
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        <location>
            <begin position="211"/>
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        </location>
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        <location>
            <begin position="801"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB77219.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6R4</accession>
    <name>A0A2T4C6R4_TRILO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1206660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="67" mass="7400" checksum="AD4BDF4EC6090740" modified="2018-07-18" version="1">MNSILPVLINLVLPYSKTPCHGISAYVHNVSPHPPYKVQAPPPLIHHVLQKLRASLSSFFLCISLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C717</accession>
    <name>A0A2T4C717_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_278101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="95" mass="9960" checksum="BA051A88C9CD1CCA" modified="2018-07-18" version="1">MDDQRPDDGYIVQGPALGPSCCTLQSTPSPPGSPRPAGEGRASTSFPKPNRRRLSTNGPWRASGLGAGLRSGLAWSDLGLVDGRLLQWLDARSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C796</accession>
    <name>A0A2T4C796_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1311940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C796"/>
    <dbReference type="STRING" id="983965.A0A2T4C796"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="221" mass="24399" checksum="C3569A71465EC2F9" modified="2018-07-18" version="1" fragment="single">CPPDPAFATETSFDFTRTSWEDDQFTSFWSADSSTVKDKRQLVLNSTDGKGAAFTVWQDGQAPTLTSNKYLLFGKVSVQVQAAKGPGLITAIVLKSDSGDEIDWELLGAYENQAQTNYFYDGQPLFNTYNTTHHLDASSFAQPHTYAIEWTPLNLTFSIDGVVRKTWHHHPGDLDSADYVIPASKWPQTPMQLKLGIWSVSNASDPGTVSWAGGLPDWSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7B0</accession>
    <name>A0A2T4C7B0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_65457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7B0"/>
    <dbReference type="STRING" id="983965.A0A2T4C7B0"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB77435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="397" mass="45300" checksum="489E0683F71C1F33" modified="2018-07-18" version="1">MAGVADKARFYLERSVNQLREWETKSIFTKDEIRAIVQKRNDFEHRVLSPGNTPSEWSSYARWEQSLQTLCSKRCQRLKLRNLNSAHASQTRVLAIYNRGVNKHSGSAPLWREYLAYLAKVKAAKRWRKTMTRAIRMLPKDPELWTMAANRFASDGDMASARNCFMRGCRFCTSDCGLWLEYARCEMKWLDKMEKKKAKGETVLPPRPANDDDELMLLGSDDEDEGEDLSLPEPSAKQTKVFNEEATQELASNPAMDGAIPMAIFDISQKQSFFNADVAEQFYFMFSSFHKLSVQPRISQHVLEALDQQFPNDPATCNCHIRQPLLGVSPYTVEFPRQLAVALQRLGTYLESTTDRASLEKKTTAWIDAYLQLEDLDAALRTVLERTRAKVSGTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7C0</accession>
    <name>A0A2T4C7C0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1331533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7C0"/>
    <dbReference type="STRING" id="983965.A0A2T4C7C0"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="148"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="290" mass="31843" checksum="AB88233FFF5F73DD" modified="2018-07-18" version="1">MTEQQPKTITYRGNCHCGAFVFTTTLPEIKSAFHCNCSICTKKGYLWIFPGKGNVEIVKGSVEGLTAYEFGPKKLKHLFCPKCASPVAGSSEDEEEDMKLALNVSPVAVLNTWELERTPYDGASLGEAYQHPVHKGALPTPEADEIVYTGSCHCGAVTVAAASTPLDETYEGAIECNCSICERYAAIWVYRPNKSVVLAGDEANIGRYQFNTRALSKVFCKICGVVMANQFKTLTDEEVEALPELPRKIYDAQHEYTGVNGRVLQGVDVGRFKTKRVDGLNKIPGEYPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7D1</accession>
    <name>A0A2T4C7D1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_18601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7D1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7D1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015644254" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="802"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="820"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1057"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB77471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118908" checksum="B40EE4300573DEC2" modified="2018-07-18" version="1">MARRRYRLFMICAAVILFLLYRVSQNTWDDSAHYATLRHPPASNPPATGGEGPLKPAANPDHEHEHGYAPESKPESKPEPKPAPEHAAGEQKTQGKPSFDDDEETGVKLPKLKDLDDSKAPANGKPPVQADADSKPAGNKPASTDEDAVIEDIHQKNPPKDATIPSDNRLPPDNKVHWRPVEEHFPVPSESVHSLPTGKPLKVPRVQHEFGIESPEAKSRRVARQERVGKEIERAWSGYKKFAWMHDELSPVSAKHRDPFCGWAATLVDSLDTLWIAGLREEFDEAAKAVEHIDFTTTPRNNIPVFETTIRYLGGLLGAFDVSGGHDGGYPMLLTKAVELAEILMGIFDTPNRMPVLYYQWQPEYASQPHRAGSVGIAELGTLSMEFTRLAQLTSQYKYYDAVDRITDALIELQKQGTSIPGLFPENLDASGCNHTATAIRSSLSEAAQKQMDEDLSKKPENYRPGRSTKAEPHAVEKQPGKEQTVDENEFGKFNSDSGFVVGKIGTEDPRDDQTQAAQPDAPAKGFVVGKIGAEDPRDEQKPPEASGTKASNFVVGKIGSENPDYAKQGPREDDKTETRPSDPSLRRRGVSAGEGEPLDKAKQVPSQQTAKRGAPPFGANGFTANWDCVPQGLVVGGYGFQQYHMGGGQDSAYEYFPKEYLLLGGLESKYQKLYVDAVEAINEWLLYRPMTDGDWDILFPAKVSTAGNPSQDLMATFEVTHLTCFIGGMYGLGGKIFGREKDLETAKRLTDGCVWAYQSTVSGIMPEGSQVLACPTLEKCNFNETLWWEKLDPAKDWRDKQVAEWEEQKTSLQKQQSKKTPEDKGDPRKTSDKDKAIAGEALKETANNHDAAGGSKAIHKRAALPPPKPQADDDAGSELPQSLKDKIGFKNDEQKKSTGSSVGIQRDPDAPVDSVLEAHRLPPQEPEEQQIILPEKPQTHEEFVKQKIAEEGFAPGVVHISSRQYILRPEAIESVWYMYRITGDPIWMEKGWKMFEATIRATRTEIANSAIDDVNSEEPGLKDEMESFWLAETLKYYYLLFSEPSVISLDEWVLNTEAHPFKRPGGSVIGHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8I1</accession>
    <name>A0A2T4C8I1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1400765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8I1"/>
    <dbReference type="STRING" id="983965.A0A2T4C8I1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="32625" checksum="584ECF1B244C24A3" modified="2018-07-18" version="1">MARPYEGKLAIVTGASRGIGAAVARRLAAKGSNVLITFTSDSSREFTRQLVDELSSKHGVHVQSVQTDLAQASTAAPIIVEAARALFSSYNSPSSDKKRFQVDILVNNAGVSSNQFLNDPEKGPIEEAEFTRVYAINVLAPLLLTQAVAPHLPSDRSGRIVNVSSVSASIGYPGQSVYAGSKGALEVMTRTWARELAERATVNAVNPGPAWGDMYAEAGPAFWRRNQPYVDAAPLMAYDGEEEVLRRVGGEADKFDRLVREQMGGRRPGFVDEIAGTVDMLCTEEGGWTTGSVVCANGGMRMSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8T1</accession>
    <name>A0A2T4C8T1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein Scm3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1330399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8T1"/>
    <dbReference type="OrthoDB" id="2420608at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110607" checksum="DF5F3902EB84FBCA" modified="2018-07-18" version="1">MEPPAKRRRMSQLLLDKNHADEDDDELAFRPFEVEAKRDPDYRLSVERAYADQRFQATMAHIFEKYGRDFEGIGDEIDLVTGEIVVNNGHVRNMRDEGDVGDGLRGDLTDGEGDEDEGIQLEDLYGDEEEYEEEETKEKGNPAGFGSERAHNGNGADDDEEEDRIIQGRQPTRDSHSTALVLGSLSRNALLARASPFGPHNANPLHFEPPTELPFASSPFSFDRSPFASEPWGAPGQFSDPLWDRPDLFAVQRPPSQQLPLKPSRYQFPARSGQSSIWAPGSRFRADDEEPLPSAFAATFGKHLLPRRRKILKHPLLLPSTKSIEKEVDGRAEAEEDEEDEDVILTGKRSRENPTEAPKQPDDLGESNHSAGKEVEERGGEGTSSDSGYKSAQSTRRSRKRKQRADEGSPMDEALVQPPGISRKASSSKSKRMPRKAKNPDQTTSSLELPDGANGCRRSARMRKQVEYLNKIPWAQALAEQKAQKQAALLPASDSQNSDDDARAEDESSAGLDSAVDDEAALTGSEHDCIPDSAAEDEDEDEEEEEKEAEGEAEAEDAVEAQREQEEGDDAEEKEEVEREVSPPLVDLPTSHEPQIRQPDIVERRRNQAPTGFTFKPSNPACFLSDDEAPTILSKPRKLTTQTRHENVLPLREIRNVKAQEPAEISPSDAGKEGRPKQSSKKRRHEAEARIDSSPTANKGGVSNLDVSPEDASGVARLSSSPTRFLTRITSRVSLGDTPRSLDTIPEKAGHEPVPEPQAARSSSPCARVSEDTPRSTASRRKRRQSNKPSRPAPTKQTALPTVIEDSSNETSDDISHDESSSPAKAFLQEEPAPPSPKRTALSPLEPESRPSTQSPSKVIPRSPVKPPSKNPAKRAFAAEADDPLPSLSNPPQTPRRPNRRLKVPSSRHSILSLLSDDDEEEIDELGRNLTAMPRLQSSVAQTTARKVWRSSSRTREVYRTPVKKRPSEPVSPGSLVKTPGGTLRACGVDGYRCGRDFCFTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8U8</accession>
    <name>A0A2T4C8U8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleosomal binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1375687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8U8"/>
    <dbReference type="STRING" id="983965.A0A2T4C8U8"/>
    <dbReference type="OrthoDB" id="5241710at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29942" checksum="D3AD9E71C84CAF0B" modified="2018-07-18" version="1">MEESSSSIAAAVRPLRIVAVLSFIPSFALSIAHGVLSHKAVPAVGLVPQAVSVATSIALLGSSASASRQSAEPDVESIDSASRSAFSVRAFLTHPITVFIQDAILATALMVVLVFTWTHHGRSASLSMLAAYATLPILTSFFCHLLAACLAVYQGLAIHGLLQWVAWQILPPSCPNCEHHLRPTSLPEIPWFQSINSLNLGLRCPWRRSDDDAPLLAPLLAEDDPERYRDDPEDDEATPQPEAVAVRPKRTRKTKATPAPSDEASETDQLGDLSVRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9P7</accession>
    <name>A0A2T4C9P7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1468742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9P7"/>
    <dbReference type="STRING" id="983965.A0A2T4C9P7"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="417" mass="45522" checksum="73FC560D4D2C1B80" modified="2018-07-18" version="1">MPRDPLIGLVGKPSAGKSSMLNSLTDASSKVGNFPFTTIDPQRAIGYLQIDCACARFKLQDKCKPNYGACVDGRRSVPIELLDVAGLVPGAHQGRGLGNKFLDDLRHADALIHVVDASGTVDAEGKETRGYDPSVDIAWLRSEIVAWILGNLMQKWGGIKRRHIAVKATAVETLQNQFSGYGSTPVTVQRTLDRSGVKEPLEEWSDETIEHIVNCFIDEKFPTVIALNKIDHPDADKNIAKIAKMQDPNTVVLCSAISEIFLRKMAKQGYIKYVEGSEFVDTREDLIEQGDPTGGGLKELDEKNRNRIENLKDMVLYRFGSTGVVQVLSKAAELLGLVPVFPVRNTTTFSSGASESKFVFRDCVLVRKGLTVGDVARKVMGDAPIAFVEGVGNMRVSEDDPVAVGKNDILSFKVGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA42</accession>
    <name>A0A2T4CA42_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1328551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CA42"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1328" mass="142922" checksum="CB59D5365900054D" modified="2018-07-18" version="1">MASPMPAHSGGWHQPPAAGETVDEYGLQTKFMNLKVHYTFDKEAKEKCLARGSQPLQVQIVPLDDSSTIGIVDLRACVHVIAECSPELTNRDGDYTIYAIDYSEPDLPLVGQGLLSWAFQSMRPDFGNYPPKMVTGRVTRNILGVFGGGNRETLEVRLKLSATARIQRSVTYAPPPMDQQPARPMDQQALPPHAAAEWNSLVQSNAQGAPQQASHSYGGPPPPASMHNSHSPGMAHALPPGPPPPLARQGSFGPSYNQNSPAQEQARIAPIPVDTQSQPMPSIPAPSSRPSSRASNRPPRRKPPTGRPRGRPRKKPNEGNTSGYEDGTEGEEAAPPKEDEPVKKRAKVTKVDKADATPFAAEPESLRVAASNSSSLRNFRPLAINSDSVTGSHLQEVPRAPTPVPNGRLRAVPGREPSSLKRRESALSQRPVSSFATSEMGGFPSPGMDDDRSPDSTAPTPNYPEDSPADIGSSPPVQQATPYMRSSPPPSSPVLPPMPAMARQESRRSGNDARELFGEGDQSLMEELPPQPRTHNAPKQSVPVQVFQLQDGPSGQDLVHVRTYNTPYPTSNTPASAESSLPPPARRDSSRPQSNAQTTKRKRPQSTSTSPTLAPTPPPTTDAVERAMSPNLTSTPAPIQAPTPIPLPPTIRAPDSIQEPIFVPIPAATSPTNAAEGPAPTPAAAPAPTESFATTTPTPELSQLGDLTDDIFNDPIVQLASTFSSRDEAPPPLQPPSRSSQPPQSKPQTSNKPRHPRQLNRSQSAGPLVLPSTPASDPIGPSALSQPPAVASDRPSSVGGADMRRPSSMGQLALPLPESAADPTPSANPAVSEEPYPPSDFHPPPSSPPAQRSNKNIVKKHAIKQRLEEAINNGEMPPFCSNCGAIETPTWRKIWIQERDGVPERCEYSEKPGKITAVEVLQRDEDGNPTLHRVVKKSLAITDEKTKWQESLLCNPCGIWLTKCKTHRPPDRWDKDASRLGQERRKRGTGRSTSRPKKNRPKDDGPFNLTSEAYLPTDALEPIAPSSPKMGEVISLDTNPSQRTERVENQDKDKVNGNIDLEVRSQPGSSHSQGSGTAQSPIDIEFDEMAGRTKRLLFPSPRKEGVPKVLCNVDINIVQTAEYRQGGQLKGDQENVATAVAGSHGSTSKLDDLEALFNSPLKERPSTPPPDAAPAPADAFKTPTRPTPSHRPITRSVSRSLRSARSNLSPNQHTLEQQTPTKTPRSMLRVPGSSARRRSPRTHQGSFDVFDSPVSRSIVQLLSEGNVLGTGENEVDLSSLPGLGHIEEGFDFSLLSTDNLMPSSPSRTGSTGLTFDYDGVGNDIGDWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAF6</accession>
    <name>A0A2T4CAF6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1399647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAF6"/>
    <dbReference type="STRING" id="983965.A0A2T4CAF6"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="374" mass="40794" checksum="E99A10D633CA6021" modified="2018-07-18" version="1">MVKETKLYDTLGVKPDASQDEIKKGYRKAALKWHPDKNKDNPNASEKFKECSQAYEILSDPEKRKIYDQYGLEFLLRGGAPPPEGATPGANPFAGAGGMPGGFAGFDFGGGMPGGGGARTFHFSTGGGGGGKGYNFMNPEDLFAEFTRSGGMHTGGGGDDDDFGFFSTFGGAGGPRPSRTRTRSNFADAQPRREPTPEITTVERPLPLTLEELHSGTTKKMKIKRKTFDESGKRVQTDQILEVPIKPGLKKGSKIKFNGVGDQVEGGRQDLHFIVEEKEHPLFKREDNDVVHTVTLDLKEALTGWKRVVSTIDGKQISIEKGGPTQPGSEDRYPGLGMPLSKKPGQRGDFIVRYKVNFPTSLTPEQKQKLKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAT4</accession>
    <name>A0A2T4CAT4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1399818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAT4"/>
    <dbReference type="STRING" id="983965.A0A2T4CAT4"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="51"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="354" mass="39378" checksum="4896445789447647" modified="2018-07-18" version="1">MATLTLTSTISPRVLAYKPPHPELREFVPARDRAFFADPEKASLLSSATAIEQLTPLIGTELKGVQLSKLTDQQKDELALLVAERGVVFFRDQDITLDQQHALASYYGIQDRDPNQQDPRHVTIIGRGGNIRGHGNFSSEWHGDHSFEVNPPSYTLLRMVKTPPSGGDTIFTSQTGLYDALSPAFQRAIEGLHGVHSSDKTYLASINGGGTPHRAPIVTAHPLVRTHPVTRLKSLFYNPHFVDRIQELNAQESHHILAFLREHLSNADDLTVRWKWTPGAVAFWDNRVIAHKAVPGHYDTELREGKRTAVHGERPFYDPENSESLSERAARLAKEKGASGDGIVEQTKELVLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBC5</accession>
    <name>A0A2T4CBC5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1461843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBC5"/>
    <dbReference type="STRING" id="983965.A0A2T4CBC5"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015563723" description="DUF7580 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="212"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="581" mass="65267" checksum="C017209F18E07A47" modified="2018-07-18" version="1">MSRFEAFGIVLHAIPILISGAELCRDGYGKGKLAFRKRKYVEKLARSLLLHQQTLLETVRLIITRSGHSFDETVFLSGNSLAYFQDGNIQSQVESFLGDDNYRALTGRIQDIQGILEEVAKHLDGLIPSYKDDPSNLVGIIEANQVAQKHKADIIPRIKVALKSDAIKQSISELDTATSTLHTFSQTVLMNRHGPISSLVSSSNLRLAKAFRRIQSASKNLYTALCRCCTGSCHNEHNVHVLLEDRVDVASELVRSTKRMSDEETTALAFQLIFAAKILAPIQIRCHELSVKCMQEDESDLNSEEVQSKSRVKIVDQECAKTQGYGSLQSKFIPIDNFCSAVVAAHDEAQPVAFILHTSNRMGFITSKQKTVMLKSNYQAISLRDILSKSSGAYGSRLPLQSAMLLASKLASSLLQYAQTQWFGQAWTKDSIFFLLFNIEDERKRSLADFNRPFVCAKIEDTKTNAAYAAEPKSTLLELGILLLEIWHQTTLESRFADKADRFTSDYFTRLSLAAQWLDDDYDTPLPLYEQAVRYCVYGASTKRWTEWNTSELWGEICKEVIKPLSDNCGQWKGNAVTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBD8</accession>
    <name>A0A2T4CBD8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1352752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBD8"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000388">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000451">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF48">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="569" mass="61839" checksum="613D486B1E3B10EB" modified="2018-07-18" version="1">MSSNPADGAAMQPKKGVFRQLRENPYIFGLSAFASLGGFLFGYDQGVVSGVLGMENFGALFPRIYLDSSFKGWFVSTLLLTAWLGSLLNGPIADRFGRKGSMMAAVVVFLLGSALQAGASTIGMLFGGRAVAGLAVGMLTMIVPMYMSEVSTAGIRGTLVVLQQLSITLGILVSYWLEYGTQYIGGTRCAPEIPYSGGTAEKPTFNPQNDVGPNGCTGQSQAAWRIPFALQIVPALVLGIGMIFYPESPRFHLMRKNEDAALRSLARLRRVHPDSDSLREEYLSIKAEVMFDETHSRENYPGKSGASLFFAEYYGLLSNWPTFKRVFIGSAIMFLQQFQGCNALIYYAPTIFGQLGLSGNTTSLLATGVYGIVNTLSTLPALFLIDRVGRRPLLMCGATGTFISLIIVGSIVGKYGDALSQHATAGWVGIAFIYIYDINFSYSFAPIGWVYPSEIFNLGSRSKAMAITTSSTWMCNFIIGLVTPDMLETLKWGTYIFFAAFCLIGLVFTYFCVPETKGRSLEDMDRVFGDETALKEKERLFAIAASLGLTASIPAEKTEAITAEAEEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBE1</accession>
    <name>A0A2T4CBE1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1390457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBE1"/>
    <dbReference type="STRING" id="983965.A0A2T4CBE1"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="328" mass="35575" checksum="F7DCF70C6E171CE6" modified="2018-07-18" version="1">MTIRVLVNAALLAIPIAVTLGILFGLQSHRAATGQPPLFAPEPPPIPTPKPKVPHNGITKTRYCQKSIGITPETKGQQYTLNPNQWNWKSGDPGGLCLNVTTFNNGTYATDTTAPQFMISWQYPPGPEDNPVHAFPNIQVDTDVFPTTINTISKVDLDLEWSYGIGNETTEAATLAELKADNLNTNVAIDMFIDSDKKAAQNPSKAKYELMVWFAAIGPATQPIGFAQGSVSTQTLDGNKFDLYAGVNQQKQNVLTWYTDTPVEKFNGDISPLINSLFKLTATDADLPKSGDYLGYLALGSEAFSADKTVTLYVPKLSIDIETDTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBN5</accession>
    <name>A0A2T4CBN5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_225197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBN5"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="169" mass="19499" checksum="CDF6E269D78C96B6" modified="2018-07-18" version="1">MPSLTRIFLASGQLEFKLMDVVLHTDQQSHAAARTRSGCDCSTPHALCQSDLYRLTTSSMRRMRNGCWLKGIKAPHRFSALHCIASRIKTERAPQSQAHCMYTASAILEMHQTCVLVTTSLILRGRRWSEPGNRRRCRLFQSWMQHDSSRLMPLHLDQDRAQFQTRESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBZ4</accession>
    <name>A0A2T4CBZ4_TRILO</name>
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        <submittedName>
            <fullName evidence="4">XAP5-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">M440DRAFT_1326907</name>
    </gene>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04921">
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="41"/>
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        </location>
    </feature>
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            <begin position="51"/>
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        </location>
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            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
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            <begin position="120"/>
            <end position="129"/>
        </location>
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        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="380" mass="41354" checksum="C34CD9F9143F4365" modified="2018-07-18" version="1">MSNQQASRFTPQNKTTNERLSTTTVGLVALSDFRKRRAEVLEQQEREAREAALSSAGAGTSSSSSKLAPPDRSQTGTPDNAGSDSAEPGSGASGADGPLRKKAKKKKAKQNPGKKLLSFGDEDEDEENGGGESEAVSARAASTEPSSDKDAAAGEKKAKIKANAAVGLIPKAVTKAALRKEAAERERLRREFVALQEAVKNTEIAIPFVFYDGANIPGGTVRMKKGDFVWVFLDKGRKVGAELGVGEQTNAQRAWARAGVDDLMLVRGTVIIPHHYDFYYFIVNKTTGPGGKRLFDYSAEAPIQPSSTDDSDAAKARQPDISTLEGYNEDPTLTKVVDRRWYERHKHIFPASTWQEFDPEMDYSTQIRKDNGGNTFFFAK</sequence>
</entry>
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    <accession>A0A2T4CCW0</accession>
    <name>A0A2T4CCW0_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">M440DRAFT_1398657</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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            <begin position="103"/>
            <end position="126"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB79385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="153" mass="16711" checksum="B010DC2B900D255F" modified="2018-07-18" version="1">MFSYHPCSGHFIHCLHVANLPLQLNLLASCHPIPPRTSKTASAKFCRWPRDEHPCVHRTVPNSVLRSPLAAPAQAPLLLLSPTAHTTRQTVSRRARCTGIKNLRVGSSQGPSPLGTRRQPGNGTTTLDNYYPATPYLPSDVFVLAVLPMDAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CD35</accession>
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    <protein>
        <submittedName>
            <fullName evidence="5">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">M440DRAFT_1327229</name>
    </gene>
    <organism evidence="5 6">
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CD35"/>
    <dbReference type="STRING" id="983965.A0A2T4CD35"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="307"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
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            <begin position="96"/>
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        </location>
    </feature>
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            <begin position="211"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="54"/>
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            <begin position="121"/>
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            <begin position="214"/>
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        <location>
            <begin position="241"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB79456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="532" mass="59866" checksum="8E830CE22A0F23F9" modified="2018-07-18" version="1">MDSSESVNQSAGESTPLLPSSDASRPKPVRTVTFSANPVSRTIEPEPQRIPRSYASNNVSQPAGGSAVAGPPMLAALNSKLRRRNSQGFVPVAQAQGLPKIGPQRSTKKTEKLKLLPNPDLAEEAEDEESGRDVYAQYTRIKDPTARRDAARLGKADRDRLPRVTAYCTANRYEMDGLMRFLKGRGKTRGANPKLIDECIYTPYMYGKSHRHHEVTERNHDVTEHSLGRRHSTGSEPVEGETERDHFRSLRHDNQDSGYGEGLMGEQARHEAGELPSEELLGPSMPEHTSMKDSVPDFDIEIHTPEVFLFDYGVVVIWGMTEAQEAKFLKDIAKFELEKLAPDDVETEQFNFYYTREYQARIYNDFITLRDKNNYMTKLAISHALAQSVKTSLFEELIASTIETCKDIPTQIALTGKINLSRKQINMQIGELFILRINIHLNGSVLDTPEFFWVEPQLEPLYQAARSYLEMDQRVGLVTERLDVIADLLAVLKDQLTHGHGEMLEWIVIILIAMEILVAAINIVVDLYAGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDC0</accession>
    <name>A0A2T4CDC0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1326738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDC0"/>
    <dbReference type="STRING" id="983965.A0A2T4CDC0"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="120" mass="13139" checksum="A2777A6202A0694E" modified="2018-07-18" version="1">MPPPSPLVIATGAVTRLLKEEASYHKELQEQEAKVKAQEEKIQSGQDDEEGNATYILKQHQMVVEQTRAVFKPLRNRINQAVEKLEDLVAAEEKGGSASEEELANAKAALEKAKAENASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDC8</accession>
    <name>A0A2T4CDC8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1398821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDC8"/>
    <dbReference type="STRING" id="983965.A0A2T4CDC8"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="276" mass="29904" checksum="6AFB56B4956C7FE2" modified="2018-07-18" version="1">MSMTVEDCTRVRPGFPRPVPDTPANVLQQFQMKGKVVVVTGAADGIGLAVAEGFAEAGADVAMWYNSNDAAVERARGFEEMHNVRAVAYQVDVSKAEQVKGCIERVVGDFGKIDVFVANAGMAISKPILEQTLEEYQKQMSVNVDGVVFCSKYIGETFKSQGHGNLIITSSMSAHIVNVPVDQPVYNATKAFVTHFGKSLAREWRDFARVNVVSPGFFDTKMGAGELSLQEAYRMAALGRQGHVKEIKGLYLYLGSEASSFMTGSDVLIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDD2</accession>
    <name>A0A2T4CDD2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_240391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDD2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14004" checksum="C9C9BDAD89C63822" modified="2018-07-18" version="1">MNPALSFSSVGACVFSGIYLVRCAYGVCMEEAGLGWTGLGWLCDILGEDDRMRVDGWVHESFSGSGDLLGLSWGESLHVIMFSDHMGKAKKEKTRVSLSVSPVVWIFLLGLAGFALVYFELVAFCHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDH4</accession>
    <name>A0A2T4CDH4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1173830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDH4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB79603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="100" mass="11423" checksum="9F0F8BFC9E61F67B" modified="2018-07-18" version="1">MNERTKKMPSPLPPQSLQCGRLLMQCKANPSDKKEKKKQSKAKQSKAKQSKRRAKLPPLEQVSLVNKKTCFFFLALVFQLFCLAFLSHSQVDHLGLHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CE70</accession>
    <name>A0A2T4CE70_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1429087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CE70"/>
    <dbReference type="STRING" id="983965.A0A2T4CE70"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="44"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB79828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="209" mass="22696" checksum="24C230121DB1C671" modified="2018-07-18" version="1">MAARTASRRLLLHNLPGPLSRRAFISLPGTSPSPQTLVATRTLPYAREPLYELIADVDSYSSFVPYCSRSRVTQWSPPDASGRRWPALADLHVGWGGFDEKFTSRLRCVPGVSVEARSGGSAGDGDDSGPAKDASSVFKTLETLWSLTPVKTQPAATTPSTEVRLTITFEFVNPLYAAVSAAVSDKMAGLMIEAFEKRVHDKLSAQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEY5</accession>
    <name>A0A2T4CEY5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1347823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEY5"/>
    <dbReference type="STRING" id="983965.A0A2T4CEY5"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="217"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="363" mass="40606" checksum="8F4A1DE56E12C057" modified="2018-07-18" version="1">MKSKRAAAASTEDARPVDVPQDQASKKRKRSDDDADQSNDATAGKGDKRVKKFREERKEKKKEKKEKRKHDKEERKAKMPKKDKSKYNNKSRKEKKEELKNLQNLPEGMDVDDDEAGAKAAEAVTKPEAEAEPKTNGKSEDKASRKQDKEDKKKDKEDKKKDKEDKKKDKEDKKKEKKEKKKAEKESKGETSSAKNATQGEDAIDLDPSAAEKAGRNIVFVGNLPYSATATSITAHFASLKPVAVRCLTKKEDPKACRGIAFVEFATSTHQRTCLDKFHHTMFDDGISPPRKINIELTAGGGGKGQGRKDKIMEKNKKLDENRAKRIEKEKTAKEENQSGNGSAAARMDVHPSRLARLPGLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF03</accession>
    <name>A0A2T4CF03_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1435830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF03"/>
    <dbReference type="STRING" id="983965.A0A2T4CF03"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38904" checksum="DB6FC9D8107EC633" modified="2018-07-18" version="1">MPPVFSEHVEHYDLETIFPYRPVRYRFLLASLFRFTSIFGTCSICAWNPCILVPLTDSFWTPRRNFSIVAVHCLNIEARYCLYKDTWCYSSKLWPRDILPSCFEKRCRIMLFSWNDGLAVTEEDSRFVKHGDRLLRLLMENRLEDPQRPIVFLCHGVGGLIVKEALAKAHLDKTGTIHIIDQCTRMLAFFNTPHHNVAKSVRNIASAAVNPTAPEVLDKLDKACEEHVERMAAMEARGRLYRRRVIINFHGTSLYRGTGMLLVEKEDSKINARPEYWEKYFPIYGDHTSMCRYPSSEDMVGETVIKTIGLNTYLALRRGFAFKGFLVLSNSHRSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFD7</accession>
    <name>A0A2T4CFD7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF663-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1388599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFD7"/>
    <dbReference type="STRING" id="983965.A0A2T4CFD7"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="63"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="616"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="628"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1092" mass="124261" checksum="764652184DF0D42D" modified="2018-07-18" version="1">MEDQTHKPHRKSKEKKQQSGDRNPKAFAFARPGKLQRQAARSSDIKEKRLHVPLVDRLPDEAPPRLVAIVGPPGVGKTTLLKSLIRRYAKETISDPQGPITVVTSKKQRLTFMECPNELEAMVDVAKVADIILLMIDGNYGFEMETMEFLNILAATGMPGNVFGVLTHLDLFRKPSALKDAKKHLKRRLWTELYQGAHLFYLSGVMNGRYPDREIHNLSRFLSVMKSPRPLVWRNTHPYTIIDSFRDITHPTKIEEDPKCDRSIVLSGYLRGTNFATQGQRVHVAGLGDFTVSSMEVLPDPCPTPAMEQALAKITGKKGRRRLDEKEKKLYAPMSDRSGLKIDGDAIWITREKGFTFDKDADNVERGEGEEMIIGLQAERRLLGQTDDGVQLFKGGQEVKALDEAQDTGRKEPRKARMAEREEGDDGENEDDEGFISGSDEEDPEEGEEFNEEKLGSMFRNKDADKVANGDDDVAFADSDSDLGSITDLDEDEDAEDGEEYDSDEESAALRWKEGMADRAMKLHSRKRSYHTADLARYLYDGSMTASEVIKKWKGEEDAEDSEEEDIEQDSEDEEFFKKTSQESEDLIEDRSIPEYDYEDLAAKWASQENIEALKRKFTSGRRGGGGDGDEDEEGDFGGFDDDEDGDGDEGGEDSEGDGEFEDLEADPQKPSTQQQTAEEIQAEREKNAKRKEELKARFEEEDRDGFLNDKAKARREGAEDEQEFGEDDWYDAQKAMIKKQLDINKEEFENLDERQRVAVEGYRAGKYAKLVLEGVPAEFVSRFNARLPIIVGGLSPTEDRWGFVQVRIKRHRWHKKILKTNDPLIFSLGWRRFQTLPIYSISDSRTRNRMLKYTPEHMHCFATVYAPLIAPNTGFVCFNSFSSATPGFRIAATGTVLSVDESTEIVKKLKLTGTPYKIFKNTAFIKGMFNSALEIAKFEGASIKTVSGVRGQIKRALSKPEGHFRATFEDKILASDIVFLRAWYPIKPHRFYNPVTNLIGWQPMRLTGEVAKRRAKKDETRAAFKKRLAEGDEKREAREKRESKEYWRKNGRKRSAGDDEGGGGKRRRFSFWHQGYIHLMLCNTYLISYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG81</accession>
    <name>A0A2T4CG81_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAP42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG81"/>
    <dbReference type="STRING" id="983965.A0A2T4CG81"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="354" mass="39204" checksum="DD2233716246EBDA" modified="2018-07-18" version="1">MASFDEPQSLRAIFEAAEAKRQEITEAPNATSPKYAEDLAAALKLYAQARDQISALSLFSANEGVEDIATSSLPYLLVDFYIGELVQRTPHLAPKERLQVLDQARAAYERFLSLADGYGLVTPPYDRLLERYRDDEEGFAVVPAGADMAAKREGKIANFKAEKALKDKMEALRRNPRYLEHGDEELVRELYLTSIRFAVHGAFQALDSLNREVPLLRSAPSPREDASSSRGEDPTDTSFRLDQPFNGFRAGAGGPLLSTKGKPLQPFTLVGSRADLAKGVFRPGHNLPTMSIDEYLEEEKRRGGILEGGGTEPPRKVVDEDDMEAADRETYKARAWDDFTDDNRKGSGNTLNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGA7</accession>
    <name>A0A2T4CGA7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1129806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGA7"/>
    <dbReference type="STRING" id="983965.A0A2T4CGA7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="780" mass="85337" checksum="65098A4B5F38F816" modified="2018-07-18" version="1">MQDSRMTRVSMVSLVRFSSVYGCSYEMTAAWTTESSLHLTVGEHYQFMSIFPGWDHGIIGMAVGGERRLTVPAHLADSKNVTSVPSNCQLILDIRLLEISGESFEEADFSGYRADFELGAGKDGPRKEAFESETDRGGLPPSFRDNAEPQTTTERYDVEFVEAHHPAGMEKWLQETPPDQSGLLPRELSPTEADLARKKWGLVNDFVNRIRDAPTTSASAGLRPADQKAIDKPEPQGPLGSTATASSEGSKTLDSRPIGLPSQEVTAAPATLNVKKPKLVKSCTECRRRKLRCDRLFPCSRCIPANIDCRYVPDQKSANLPNGSDAEGAAPSRPSLMEALQQALERELEHSGMESTGSGFVTGGGEALQDKELPQTGEEQEPENAWGTSARSWGKRVEEPYSLLALPEETHQMAEYSREAERDPASSTTPSRSSETTSYKSANAEEDSPPRLRRVGHVQFDGIAGMGLSLPSHLDDAASEGAEEAGYPLSSSSAKATGNFEVGTPSRGLAKSGNPFRNPFVEGEDPAISETEKHTCTFPGCGKTVGDFKTHMISHSDERPEKCPFTTCEYHAKGFARRYDKNRHLFTHHNGSMLCGFCPGPGSGPEMAFNHLDAFKKHLFAVHGVEQTSLDGRRAGGSGHMAPKVLAYGLNATGICSICNQFFTNVQDFYEHLDDCVARLVQQINPTSIDGDGNERPQPLDTVSGPWSSGSEPRESTSAAQAPLRPHDEDDEEMLDLAYVKETQIPLDELEGNFMRDFTCCGKTLPHIHDLILHYHEEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGN7</accession>
    <name>A0A2T4CGN7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1460569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGN7"/>
    <dbReference type="OrthoDB" id="4936392at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="443" mass="49110" checksum="D067F994FD5896E8" modified="2018-07-18" version="1">MLHHLSLPSLRSAQSSGNLVPGKHLTRKPSGLFSTSLSKLSPKSRSGSLEATKPIESIDSGSDEDDTKPRQPSKLTPIGSEEEAPNAPRSNTWGARPWHQSTLLPAPRKGNPIHSRYRSASSPGTSSESSEHFQGLMGDLKLDALDSDASILGDFDRHHRRTSSSYPSHGKASTRIQSPEPMYHQNRLSFTNLSRYGRANDRLSNLRSTLASDESYDVTMTTTTSDVMAEADTAIAGWQDQQELRPAEASFHRSPLVESTEILPGDSASQQPSPSGARLPTASPGSATGRLTWRSGSPMKNQYDGIQEANNRHQSPDSTRQPPCTPSDKNPQRPSKRKASIFSLHSRTGSISKHRKFGLRQWASSVYQQGSKRLATRLKWIRPARRDRGLFESWRKRRRGTSQEPSSPCREKAERTVEPRVCATAGWWDEGVSRFQAPDYMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGU0</accession>
    <name>A0A2T4CGU0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1370273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGU0"/>
    <dbReference type="STRING" id="983965.A0A2T4CGU0"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="441" mass="50009" checksum="D96310922154DB0C" modified="2018-07-18" version="1">MPVLRSATAGSGEAPQQHSQPSRKGKKAWRKNVDVTEVEEGLRELNNEIIRGGVIREKASEDLFTIDTAGDAKIPQKFPKHVKKGLKADEIINKRSAVPAVPMRKRPGDKSTDGLVAAKRQKTDWVSHKDLARLKKVADGHHENTIAVRDAAFDLWDAPAEQAAVPTDFLPAKVEPKVPKTMKQQPLSLLANGKQAPAVPKPTGGYSYNPSFPEYESRLAEESAKAIEAEKKRLEAEAAEAARLEAAARSAAEAEAAEQRANMSEWEEDSEWEGFQSGVEDERPSVKQPKRKTQAQRNRIKRRKEEEQLARHKAEMKARRAQEQRIKQIAAEVAEKEKQKALMLAQQQAAEEEEDDGEIKEEKLRRRQLGKYKLPEKDLELVLPDELQESLRLLKPEGNLLKDRYRSMLLRGKVEIRRHIPFKKQAKRKITEKWTHKDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGW4</accession>
    <name>A0A2T4CGW4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1135952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGW4"/>
    <dbReference type="STRING" id="983965.A0A2T4CGW4"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="232"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="881"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="943"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB80797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117920" checksum="3F78F5090A41D1D8" modified="2018-07-18" version="1">MLPSQREPHGAANDASASGLEGHLRNLILTNATPNPPPGFFPPTNPRPQASSQGLPPFPGSQPSHHPSSPAQHQANAGYHRNESAPEAAPQLGAPQHGAPQSPKPARRRPNQAQRRQMSSQLTFAPEPRTQYSQYSHPNRPDTQWASPQSQPISAPRPSEYPRSRNSWNGPPPQSPANRYQQYQPSPSARQYNAPSSQTVQQGTASAPHQYRPHMRPDEVLNQARLLDMLCSQVLAHSEIDRAEIAEKEAFRQRIQHICREVICQFEEQQDMNNRIPPISVELKCFGSLASGFATKASDLDLGLVSPLSKIPPDAPGSPIPRLIEKAFLQAGLGARLLSRTRVPIIKICERPPVELLKGLHEEREKWERGVDKDAQSGAAEVEPDHDGSAHGGDDDEHTQSGAADAGPSSLGEFDIICKDSPEPQRFQLQQGPKNSLDSYYGLAKRILRRAGGFDITGSNYRDFTESDWDILNRVCDAFIQGLADDSLRKHVATLPSISAAGMPSEAARHRSLFGLFMQVEGEHILRRWTSWAEGIPLNQLEDDKWIRQWDSLQHKSLFDIDPISHNRELQLALEKIKKIPSVQLLLLEQEQQETPAQYYTRITNVINSMRGSASAAPYAIVRRYVDGVFQEDIRQQLSDYLEQFPEQATIQAVGCRHKSIHLANELEKAVESNLYDAVSVPYIRRYVELLRQPLQMRVIAPGKTRYVVPIPAEFAATFTKIKSLTDPHTLAPNQPRERYRDPLEFPKTDVGVQCDINFSAHLALQNTLLLRCYSHTDPRVRPMILFVKHWAKVRGINSGYRGTLSSYGYVLMVLHYLVNVAKPFVCPNLQQLAPPPPSNLSSAEVQSTITCRGYNIQFWRNEEEIIRLASQNQLNRNTESVGQLLRGFFEYFAQTGLMSNGQNRGFDWGRNVLSLRTHGGILSKQEKGWTGAKTVYEVQNAAGGSPTQAAPVQLNSQPQAAPPATKSGDVKEIRLRYLFAIEDPFETDHNVARTVTHNGIVSIRNEFRRAWRILRAAGNGDFQENLLQDIEEEEGNVPATFQQLLADIHDIAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGX8</accession>
    <name>A0A2T4CGX8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1325286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGX8"/>
    <dbReference type="STRING" id="983965.A0A2T4CGX8"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="864"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="167"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB80772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="931" mass="105660" checksum="822901F9AA3CFD1E" modified="2018-07-18" version="1">MSYDTRDPSHRPWSPASRMTDYSRPPASHASYEPSDINGSPRPGTPSSRYGGSPRRPLPPAPRYGNTSRNSQFPDDITVSIPLDHPEDDDFYDPETDLSESRHHYDGYDYDHYDEEEGHYGDDRGSYHSGSQETLGEDQEYYDKYEHYGPAPDGAQERRGVRAPQMSKKEVPLINGELVLECKIPTILYSFLPRRDEVEFTHMRYTAVTCDPDDFVDRGYKLRQSIGRTTRETELFICITMYNEDEILFTRTMYAVMKNISHFCSRSRSRTWGENGWQKVVVCIISDGREKIHPRTLDALAAMGVYQHGIAKNFVNNRAVQAHVYEYTTQVSLDSDLKFKGAEKGIVPCQIIFCLKEKNSRKLNSHRWFFNAFGKALNPNVCILLDVGTRPGGNSLYHLWKAFDFDSNVAGACGEIKAMKGKYGSYLLNPLVASQNFEYKMSNILDKPLESVFGYITVLPGALSAYRYHALQNDETGHGPLSQYFKGETLHGQHADVFTANMYLAEDRILCWELVAKRGERWVLKYVKGCHGETDVPDSVPEFISQRRRWLNGAFFAAVYSLVQFRQILQTDHTLARKVLLYIEFVYQFVQLLFTYFSLANFYLAFYFVAGGLADPRVDPFGHGIGNVIFIILRYTCILLIAVQFILSLGNRPQGARRLYLGSMIVYSIIMVYTTFAIIYIVIRQFTDKDSGITFTLGNNVFTNLIVSMTSTIGLYFAMSFLYLDPWHMFTSAAQYFLLLPSYICTLQVYAFCNTHDVTWGTKGDNVMKTDLGGAIGKGDKVELEMPSEQLDIDSGYDEALRNLRDRVEVAENPPSEAQLQEDYYKSVRTYMVVSWMGLNAILAMAVSEVYSDKGIGDNFYLRFLLWSVAGLAVFRAIGSTTFAVINLIHLVVEGRIRMTLKLPSWAGGMGEKISETMSSVGSSITNTLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH15</accession>
    <name>A0A2T4CH15_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1370412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CH15"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="319"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="859"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB80834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1605" mass="177183" checksum="815748AC3D647848" modified="2018-07-18" version="1">MADSSQAPASPRNERGYPDAGEDAETRAARRELKQSSISDSPAAAAAGDVASRTVDDDAARPDTPADPVSDSADEKLKEQIPSPKKKRAHDQLDRSIDVEQNDANSVTSTESTRDRASRLEPEKKRHREEDSSRVVSNSSSIADTQPATEDAADSTTSSSKSVPQTSSAAFSASGFGKLAAGSSPFASLSTAQSSIFSPSIGSSTLSSTPSLGAPAPAPQPASSVAMPKLTFGSANSASPFASLSSGFGGASLGSPFSAGKSLSSFASPSAKPLQSEKPAKPFGAPESDAEDEDDEDADRDGESESDEQERAASPEREPEEKKRFRLHKVEVDDGEAGEATLLSVRAKMYYHDKDAGWKERGGGMLKINVPQGCIEYDETGAPILGTFDASALESSDGDDDKAQGHKVPRLLMRQDQTLRVILNTALLPAMTFQEKASLKTVSIFFTAIEGEPAKPVNVTMKAWSAEDPGVAKHSSLPAMENNTTPVPTGSKPGAPNSRKRVHEEDPLGGGDIRQAQPTTTAEKKPRTRRRESNQKQQIQTDGSDSSAPSPIPWTDSLQALERAHRALNLVYTFCSTRKHVLTTFDTLRPAVESHIKKELTVQDVAQMVALRPDALKFEYVNELMLQLNVRGGQRDDVFKSSKTFMAQAPAHDASVGGLTGNECLDDDASDKAAMNGRQVLYLEFIDGDLKRQVMDRETGEATRPTQKLRKEKLKMPVYGQKQMTQLIERRNQKFASAINSFLSKCLSDNEDPDKVLHERAQCFVPKLMASDDDAALSRMASTIPDVIPHERQSISEILDQIKQSSWYSGQIVPDGHRVFEPQSPAYGSLNFLLSQDLVNALYNAKQITQFYTHQAEALNKLHEGRNIVISTSTSSGKSLVYQLPVLHALEQDSNSRALYIFPTKALAQDQKRSLRDILSYMPGLEHAMLETFDGDTPMNLRDAIREEAKIIFTNPDMLHLTILPQEQRWRSFLKNLKFVVVDELHYYNGQLGSHVAFIMRRLRRICAAVGNRHVQFISCSATVANPEEHFKLIFGVSDVYLIDYDGSPSGRKEFLCWNTPYKEPGDPASGRGSAKFECARLFCALLLRGVRIIAFCRVRAQCEALTNAIKQELHELGRPECANLVMGYRGGYTARDRRRIETEMFQGKLLGIVATTALELGIDIGSLDCVLTWGFPYTIANLRQQSGRAGRRTKDSLSILVGDSFPTDQHYMNNPDELFSKPNCELRVDLDDMLVREGHIQCAAYEMPIREEEDMQFFGQDLPQICRERLLEDDAGFFHCHDRFRPNPAQYIAIRDAEDDHFAIVDITNGRNEVLEELEASRATFTIYDGAIFLHQGNTYLIRDFLPDQSMAKVERVNVEWTTMSRDYTDVDPVEIEAIRTISGSSCHAYYGRIKIQQNVFGFFKVDKKGRIIDAVQVDNPPVIRYSKGMWLDIPGHVLELLQDLQLNAAAAIHAAEHVIMSLLPAFVISLPGDVRTECKVALKEFAKKETKRKRPARLTFYDAKGGANGSGVSTKAFDHIDHLLERALKRVEECSCQRGCVECVASEVCKEANEVISKAGCLAILRSLLRVDIKREDLQQAPEEIYAGIETIALAKPIPLRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH52</accession>
    <name>A0A2T4CH52_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1000474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH52"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="252" mass="27323" checksum="A7FF66EFE404F5FE" modified="2018-07-18" version="1">MTQTWKMKAMPCCLASKPPLSSTTTIRSSTQPPRRVTEYMHIGAHTHTHAPHAKAPSRQAGRQTHSAHGGRMQALDPPGCTSPSESIKKERQISRMPHIDACAKPLCRCLETHVPVLSQPCRARRFEVQRPIAAAVTMPSTRACGHPSVAICQAPGTCTHLRVFAMLQVTWGARLTACRPSRQGSTLVSQFPQPSADPLESSLPYTEPFTRVSACCDVQVAETSGATIFPREGLCIRAPRGIAPQSCLLAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHE6</accession>
    <name>A0A2T4CHE6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1323387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHE6"/>
    <dbReference type="STRING" id="983965.A0A2T4CHE6"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB80948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="754" mass="81568" checksum="ED1B619EB4D2355A" modified="2018-07-18" version="1">MPQPLSPPRKPVAGTVRKPLASAAALSEVAAAAPSPKGAPATSDKTHSRLDSWSKPLDLSLNLSLNDAPQKPETGLGSHTHQQGPQEQEPFAELLSSPASSGLDLQLPFLESSKQESSKEGISSPTAEKGYPKPDRAPPSAPIAKVADKTDLTAAGSRASLGKDDISRNSRESDEATNTSQEPISFKSSATTSASSLSGINEGPECLIDEDSPGSSIIEGNLPRGQSLQHLQNRRQDYPQRVSSVPIDGIRAPSNPELVDSAGNIRRHLTPMSNNMSRSSLPRPQSAYSVVSDVQRGRSPGLMPGNSHMRAPSVQSRKSPDVRQSTYAELLNTPYPQQAPPPITLDNSGLRNAVGNNASLLSVQKTLEMYRQNVKKTNDFAVQYSFAVFLISVAQEQGLDFSDPKGRKQNPQPFRDLDSPVVEATVASPLELVREARQILQRLASAGYPFAQYYLADGFASGLFNKGKEDYNQAFPLFVLAAKHGHAESAYRTALCYEFGWGCRKDPAKAVQFLRSAASKRHPGAMTRLGKACLSGDLGEKRYREGIKWLKLAAESADAQYNAAPYHLGCLYETGYGDDIFQDLNYAAELFTQAAELGHPEANFRMGDAYEHGRLNCPRDPALSVHFYTGAAERGHAAAMMGLCAWYMVGAPPILEKDEEEAYEWARRAADMGYVKAQYAVGYFTEMGIGCRRDILEANVWYVKAADAGDERAKQRLAIIQAAVSGHGTPMEVAAPRSGKLAKGGKDDKDCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHM1</accession>
    <name>A0A2T4CHM1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1005928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHM1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="238" mass="26819" checksum="AF2DEFCC5C48A4B7" modified="2018-07-18" version="1">MQPHPLALLPSASPLRRSPASSLSTRPPSCIIITTAVLSPSTYSYLPASPSCRPAASYRYVSLRRLPGPDSVPRRVHASRRRGHPCQSMPCHALLGGEMVVMANQGGDGWRTSWPLKWELAHARDPPPLMPALRILYFAFLTPPANLLTYLPTYYYLTDRPSVSPPEPSTLFITLPEIVGRESWLRCSRPLLLLVHHDTHHHHHHRRRRKPIIDTHPIPLVIAAVPRGVRYIDTSQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHP3</accession>
    <name>A0A2T4CHP3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1434977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CHP3"/>
    <dbReference type="STRING" id="983965.A0A2T4CHP3"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="1">
        <location>
            <begin position="80"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="2">
        <location>
            <begin position="385"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49309" checksum="913787C1F40CB024" modified="2018-07-18" version="1">MTDNQEQLRKLEQQWSVVMAEDERKHALISDLFGHINELTAQLAEAHMDLRDRKDMLELKRTKLDHAEKQLDDLRRKTDEHGFCMVIIDGDNMPFHDEFVREGLLGGKKVASLLRKAIAEDVRTRFPTLPANAQVVIRVYANMKGLSKKYRELLPDAGSFEDFVRGYNTVHPTCDFIDAGCGKECADEKIKAALKFGLEDSHCKQVFFGGPGDNGYARVFDSFLEDQAIRGQITLLAGPPFAYELAAIKDKFQNVTFDNIFRSQKLPNDANRRTSFHITPPGTPMPPTPPLNFAAAAKVPSPAQSTSSQLYSPEPKPATTKVILRNRLGQRVDSRLSYSQADFSTLKDRKLCNNFHLLGKCYFLEKYGKCHHVHGEKLTAQQLEALRGIARQSPCLNGLSCSQTDCMAGHRCPRDPCHLDNCWFPKEMHNVDCQVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI19</accession>
    <name>A0A2T4CI19_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1443493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI19"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015542657" evidence="2">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="307" mass="33480" checksum="18EDD4A12ED01B29" modified="2018-07-18" version="1">MWRPGQDQGVRFLALLCTAAARFFKPLGYSSATASSMCASKSRDAAVLDLARARSCTCTGRGWLWSLSPRALQTPTGDASSARAGTQQPKYRYRRPPRAPWSTKGAFSSKVALRYTAASIRATEYAVSTHSVPPQYLYLTTFRAGANHGSSQLFQDPAPRAGRPGTVQEPSTSRANRTEALLSTSQQHHRLQSTARSGQHRNQPDETKKGTCICGHQPAQDQVTPLWAGSPVSLRSRLCTLSLNRAPQSLLRSPLRHAIIASASPGKDKQDKDKTTQDKTKNNKPALSRGFADYAPFSLVPPFSIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CI67</accession>
    <name>A0A2T4CI67_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CI67"/>
    <dbReference type="STRING" id="983965.A0A2T4CI67"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="447"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="521" mass="58200" checksum="43005211798D922A" modified="2018-07-18" version="1">MSDEVAAAPVRKKKLPFKPTALRNVAPTAKPASSAEDDKKREGDDDDDALDLFRQSREMERIVAAERERKLNRKKQKQAEEERRLSDMAEKQLLESYENPEDDAAALPAKASAAFKDAQATPVDDSPPLGADGFRELVTPPPSKRSRRDSEQGSKSSKRRRSAAEPLEDDPFHDSPAQRSTRSKPNLHTPSKRPQRVSVTPSGAPVIDLDSASASEFEPESDSEQGIDAEDNNASTAAPPSAQEREDSVEFVGSGIFSGDLLSPTPGSQNAAEMEEDDDEFDEYVRMAEAQRARDQDMMQLDSEKAVEKTAATEIMVQSSIPGTKTACIRYQFNRPLRLIRDSWIALQRRKGVQLPIESDNDIVLTWQQKRVYTNSTLLSLGIRPQGDGKLIADEYSKGGLLDGRTKVALEAWTAEGFRQWEEERLKRENGEVPEEEPTQEPEEKRKKLRVKLVAKGLDVVKLSVLPETTVETLVTVFRTQRSVASDKEVSIWFDGDRLEEHQTMEDAGIDEMDTLEVHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIR4</accession>
    <name>A0A2T4CIR4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1322433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIR4"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB81434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="106" mass="11625" checksum="937444560811AD95" modified="2018-07-18" version="1">MCNVTFFQHKSCKHIWAVLSTPCGPYMNFLTCSSFCDAAAGVKATPGFYKTASRACPRCDLGGVYDRAAVRMVERMGWGLHWGLDPEGGDWAVEVRMGEARGCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CKB2</accession>
    <name>A0A2T4CKB2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1323644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CKB2"/>
    <dbReference type="STRING" id="983965.A0A2T4CKB2"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="34015" checksum="4870CCE162DEBA7D" modified="2018-07-18" version="1">MSSDAEPVKAPEPIIHDVFEHDTGTWQYVVADPSTKSAAIIDPVLDFDRTTQGVATRTADALLALVKEKGYNVDWILETHVHADHLTAASYLQSRLAREQGYSPSIAIGKRIGQVQRFFGKRYGVPEDQYGVVFDHLMEDDENFNIGNLTATAMHLPGHTPDHMGYRIGDNVFCGDSVFHADIGTARCDFPGGSADSLFASGRRLLSLPDHVKIWTGHDYPPPDRGSPRAYMTVHEHREQNKHLRDGITAEEFVAMRNERDAKLAAPRMLHQSLQINIRGGRLPTPTDEGDRMLRLPLDLKGAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPE0</accession>
    <name>A0A2T4BPE0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Radical SAM enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1406822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPE0"/>
    <dbReference type="STRING" id="983965.A0A2T4BPE0"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="31"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="322" mass="36736" checksum="0408A76F8D1C0216" modified="2018-07-18" version="1">MTMYDLIYLLIAIAIVTLLFFYIQAPPRPRQSPPISVNYHFSRKCNMSCAFCFHTATTSHIETPQNAKRGLKLLKEAGMKKCNFAGGEPFLYPKFLGEMIDYCKDTLHLESVSIVSNGSLIKERFLQKHGRNIDILAISCDSFNEATNIKIGRGSGNQVEKLYEIASWCQKYNIKFKLNTVVNRFNHLEDMNSHLDALQPFRWKCFQVLIVAGENDSDATLRNARSLTISDEEFDDFCKRHNGQASLVPEPNSLMAKSYLILDEYMRFLDRDGKAPSESILKAGVHQALQQVFWDEAAFLERGGLYDWNKGSCSSDRNGLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BPY4</accession>
    <name>A0A2T4BPY4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1473533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BPY4"/>
    <dbReference type="OrthoDB" id="4899261at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="657" mass="73824" checksum="C69B07E51A7B58DB" modified="2018-07-18" version="1">MEATPDPQLLPVVKPMQRKVGHYVVHGLRLKLRNLRNNDLTPQIEVDFYNSLIRGIFRFVGADPNLYPECFNACTKLCWDTQALHASRWIDWSGYFQMAWSMLRAQGLTEATNLLHLPPAPLLVVVIAMRQVILCDDVGPSDQKAEFLRKYDCNRKAVTAIHFFTANFDEDVLVLNQPWNTSLEVDQQPRPNCEIMQAAQANSTPPSSMAAVNRGRGNLSATPRSNDSRRSVARSPKEPPRAAIPTALPLRMTTPRPAATPVRRPFKARSAFILSPDSPAVSSSVRARSSPSLFVSPLPFRFASTPAAVTPAARRVRSPPPPPTPVPAPMFSSPLVPAPAPVQPSPTPVRETTKRVTRGEVMLQVRPLVNRLKHEGWNGSIQTDIMRVLTDKNVRVLPYFAKQTLRIWAEASRKHTVVGWLEQAKDDEIIFEWVERNAEPVLEHEPEPEAQLESESEADSESEAEAVAEAQTEAQAEPETVQQTSRVAPSTLDVFHDLEAGIASISEPNAREQLQANLRSLKANLYTNDLKQREDMQHRIDQHDQIIRELQARISGTQQTAANTVMEPAARVVIVIESDREAPEEQQREKKKKKKKKSRKSEQEAESAEGRKKRKRKSRMAKREESDAEVADSEEERRARREAKRSKKPEAAEVNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ41</accession>
    <name>A0A2T4BQ41_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1150000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679149">
        <property type="protein sequence ID" value="PTB71414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ41"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="269" mass="29275" checksum="31808A2FFCA29DB6" modified="2018-07-18" version="1">MGSCQCLLWRSLSPSWRVPAAGEWGSGSCCSCRVLVGEPAALTSRGLMPPPPLTSYPGRSCPDFLSTSTGLACSMTAMTTARCDAVRSMMLPVAGGMKPHRDRLPRNRLRRANPRAGFEIGGASLAKFTLTPLLAMTVFCPRRCYAITMNTHSCNSVAIVRFLCFDDLPLTLVHHWFSSSLSTVLLPAITSFVAHGSGAALDGGMGIGLLFFLSLLDQRSSLLSQHHRFDSYVLHFRGKCIIINNGPPDWILFARTVALDVKQDLVWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQ69</accession>
    <name>A0A2T4BQ69_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1426462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQ69"/>
    <dbReference type="STRING" id="983965.A0A2T4BQ69"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="252" mass="27927" checksum="03915719CF02DCA8" modified="2018-07-18" version="1" fragment="single">LKVVQRGHDSGSSRPHDNTAGWDDGPWWRQVDQPRELGVVKGLVEGTKLCRVNAESYATEFFASQGGIDAVKAKARSGVLEPGSVRTSDVFLSVQAIVTDQDKALFGRTAAAAKEKKEASDADDDEDEDEFRFAIFIVDPVHEIEYATISQPIPAKWARWLEAPGPLNEAADAPQSRVHEDIRSIVEEGELDPREWVAGWLKDSLTLSVGIVAQWYVARRMQVGVNHARTRAGEKKAADEDDEEEEEESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQA1</accession>
    <name>A0A2T4BQA1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1344102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQA1"/>
    <dbReference type="STRING" id="983965.A0A2T4BQA1"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="243"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="3">
        <location>
            <begin position="496"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="69015" checksum="B69903574220DF39" modified="2018-07-18" version="1">MEKTDIQASSPISAVPQTRKRRSWHLRAACVAALLCLAGLYHHLQPPPHPHPHPHPHPHHPPHHHPHHDHHDHHGPPHDCKRPSPYGTFPKPNDPFHFLPCTNITVPPALDDRHPDKSWSRLFDPNPKHWSWGNRTDQDTEPHPRHDPFAGRGIYLCGWLDVPLDYTNVSDARITRLAVTKYQVSGLAPVRGRSKPDHWSMFAGQYREVLASPRAQLEVADALNDAIFGACYRTHGDLPRFVSTAFVARDLEEIRKALGEDELTAHMISYGTGIGQTYANMFPSSVGRMILDGTEYVKDHRLLGGFGWTALDNATDAWHDGFLGECINAGPEHCDLAKPVDGKPVTLEGLEARMETLITSLITRPVAGYTNFSGPSLVTYSGLVGAIYGSLYNAFSWPALATLLYELEAGNATLASIMLEHSSWEYDPSLPSIPNKKPSTDELTFLVICSDGYDAALPKDGLDWWESLWANMTAKSWVSGNSRFFGVFPCQHFTEYWPAPAEVYRGDLNQTLRNPVLLIAETYDPATPLRNGRRLLAEMGSNARLIAHHGYGHSSRDKSDCTDAIARGYILRGELPAEQETACFANEKPYLYGVDKGKDALAIWREHVGELPYLNPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BR48</accession>
    <name>A0A2T4BR48_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1473211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BR48"/>
    <dbReference type="STRING" id="983965.A0A2T4BR48"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB71791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="575" mass="64060" checksum="6CCE9FCD34068620" modified="2018-07-18" version="1">MTRARKQVTRSFSACWTCRRRRVKCNGGGLPCIPCRKHKVECEGYGVKLVWVDPKTGAYPPFRRRSMDLEHTWRGQPVLNEERLQRLVDEVDDIEAASLEPSPPYNPFAVFSACPSKVHARADDSITDRSPTGFAAIESRPSTPPPARSSCSLLSEDFGFVARSLTPTLINCLSASRDEAMMFHHYVTWIAPLMIPVDGAGNPWKSVYPSTALCSSSAASRALYHAILAQSAFNIANLHKDNHASSRREESVALKHYGASLRQLSQSLSITKEEEYDACAATLYTLMILEGNARGSVVWRNHFDGVGGFVTQFVQNKPWTRSARSWVISQSLALSFEISQTGNAEICGRSPITDVLLDDVASRENFGYTIGASCQVLRTISSIRLLAEKLASGDIPDDLGMSIQTYIVELSPRNHSGIGVDLDNPDRESFLKTLPEKELHNFLDSLHLRLFRTAALIYLHQAVLKVPPRGVRSLVQSVLADAMAFMHRRGGSISLWPVFIAATEATEKEDQVIVDQWLDISSQIGMRNRLVARTLIHQVWHERSHEALSRGVNPDLVMKNWKTVQQRLGVDLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRC6</accession>
    <name>A0A2T4BRC6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="11" type="ORF">M440DRAFT_1466040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 9">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRC6"/>
    <dbReference type="STRING" id="983965.A0A2T4BRC6"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8 9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015376176" description="Catalase-peroxidase" evidence="8 9">
        <location>
            <begin position="19"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="176"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-142)" evidence="8">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB71857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="792" mass="85832" checksum="F0D07E88C792CB09" modified="2018-07-18" version="1" precursor="true">MPLKNLLAIAGTLPLASAIGCPHINGNGNANVNVARAHPESILEKRFSPDGPDFGTCPRKSTVAGGGTRSRQWWPCELNLGVLRQFSEKSNPLGSDFDYASAFSKIDVAQLKKDITAVQTTSQDWWPADFGDYGPFFIRLAWHNAGTYRAVDGRGGAGQGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGSALSWADLFVFAGNTAMENMGFPTYGFGFGREDTWQSDEGIYWGGEQEMFPEALNNVVRYNGSTDFTERADKLESPLGAVSMGLIYVDPRGPNGSPDTRASALDIRETFGRMGMNDEETVALIAGGHAFGKTHGAVTGDNIGPEPNAAGIELQGLGWKNSFGSGNADNAYTSGLEVIWSRTPTKWANEFLFSLLNNNFTLTKSPDGAPQWEALDANASYPDPFIKGKFRRPTMLTSDLGLRDDPIYNNISRTFLNDFDYFTEKFGLAWYKLLHRDMGPIARYLGPEVPKKAPLIWQDPLPTPAYTTLADSDISSLKQQILAAPGLNVSNLVTTAWGSASTFRISDKRGGANGARIALQPQVNFAANNPPRLQAVLKALKGVQTKFQSSGKKVSLADLIVLGGVAAIEKAAKAAGLTLTVPFTPGRVDATQDQTDASTFAFLEPKADGFRNFGHGTASSLTEEILVDKAALLTLSPPELTVLIGGMRALSANFDGSSTGVLTSRPGQLTNDFFVNLLGSYSTWSVVNGTNEELFQSKDSNGKVQWTASRSDLIFGSHPELRALAEVYGSSDAKTKFANDFVAAWAKVMDLDRYDVKGHKSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRC8</accession>
    <name>A0A2T4BRC8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1426175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="KZ679145">
        <property type="protein sequence ID" value="PTB71844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRC8"/>
    <dbReference type="STRING" id="983965.A0A2T4BRC8"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB71844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="542" mass="60380" checksum="E687CC4083740F8D" modified="2018-07-18" version="1">MSPHSEVALGGSEPATPNGSEQAHGNGFDSSSPYIIGAMEQNTRNSAPLANGHSSESKMHKQKSPYLVESAPDSEFDLICVGFGPASLAVAVALHDALARGRQLRPDGSAPKVLFLEKQNRFAWHAGMLLPGAKMQISFIKDLATLRDPRSEFTFLNYLHRNGRLIDFTNLGTFLPARVEYEDYLRWCASFFDHLVQYGQEVVSVSPEAKKGDSVRTFAVQSRNSKTGETQSFRGRNVLIAAGGQPNFPKSFPAKHPRIIHSSQYAYMVPEILSKKDAPYRVAVLGAGQSAAEIFHNIQTLYPNSKTALIMRPEFLKPSDDSPFVNSVFNPEYIDTLFPKSARHRNNFLTEARATNYGVVRLELIEEMYERQYDQRRDLGPDQKKWPHRIMGGRQITSIEPREDSLQLKVQHVTDSEVEGFVDLVDEETLEVDLLIAATGYQRTAHVNMLRDTWDMLPKAAPVGQEYPKGITGWKVETSEGERRLTVARDYRVKYKPGSVADESGVWLQGCCEGTHGLSDSLLSVLATRSAEIVDSIFPSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSI4</accession>
    <name>A0A2T4BSI4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1405660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSI4"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="43272" checksum="7F79E630437B691F" modified="2018-07-18" version="1">MPPTISLPSKPSPNSTHPHHRHGLIYFICGNPGLVHYYTVFLECLRGMLDDLQNQPDEGRSKTVYDIYGRNLLGFSDDDHEPFVRGRNEPWDLGGQIEGIYKDVAAQRIPSPHNEEGRQAQDQQGRPYDFVILMGHSVGAYIALEIFHRHTNNPSTLASHLRLRHGFLLFPTLTHIAASPSGRRVSLLRNIPRFEENAHLLAKALLACLPYGFVFWIVKNVMGFTAQTAGVTAEWLKSRDGVWQAIHLGLSELRTICEEKWEEELWRAAVEDESDVDGYQYYHPQGDDNDAGNDDGVRGREKGRQIPKFFIFYGKDDHWVANHLRDAFIERRRECVREGHTRIVVDEGDLPHAFCVKEHTSFVVAKKVFEWVREIEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSI5</accession>
    <name>A0A2T4BSI5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1342489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSI5"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="32"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB72277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="505" mass="55753" checksum="E0F013A1B951F9ED" modified="2018-07-18" version="1">MSSPAEAAARVETGADAAAVARRVVRKIDRVIIPLLFVTYMLNFMDKVILSSAAVFGLRDDTHLVGQQYSWVSSIFYFGYLIWEYPTTILIARLPTAKYLSLNTLVWGAVVALTAACTNFGGLMAVRFLLGMAEATITPAFMFLTSTWYTRDEMPVRVGIWFAGNSIGGILSSLIAFGLGHIEDDVHPWRWMYIVLGVATFLWSIPMFFLLPDSISKAKFLTPEERQIAADRTVIAGTGRTENTHWKWDQVVECLIDPKTWLIFLIELVSQIPNSGTQSFSNIIISSFDFTSLQSTLINIPYSVITAGIIAGAGWLAGRYRTLNCLLIVVVLIPCVVGSAVIYRRDSVPHGVQLFAYFLLSPAPAAMPLSMALVQSNYRGVTKKMTVTAMLFLAYCAGNISGPQFFRADEAPTYGTAFKTIMICYSIVIVLAVTLRCYLQWFNAKRAREEGFVGNAGSAGAVADGKAPDVLDGKDVAEAVTEIQLRPEDYEDVTDWKTVGFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSN4</accession>
    <name>A0A2T4BSN4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1342360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679142">
        <property type="protein sequence ID" value="PTB72322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSN4"/>
    <dbReference type="STRING" id="983965.A0A2T4BSN4"/>
    <dbReference type="OrthoDB" id="3799394at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015418229" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="110" mass="11916" checksum="B3BC26B47443D9BA" modified="2018-07-18" version="1">MLLQSILLTLTTSLALAQSDIDRPCGFKMAPCPVDMKCVPDSAYCPHPSRCPGHCEFKNKYDQCGGFTPRPHNCRAGSQCQDDPRLPPNCGMACDAPGICVPDNAPFLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTI3</accession>
    <name>A0A2T4BTI3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity iron permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_147260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BTI3"/>
    <dbReference type="STRING" id="983965.A0A2T4BTI3"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB72623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="367" mass="40648" checksum="04751855A2A5D9D6" modified="2018-07-18" version="1">MSKNVFAVQVFFIVFRECLEAVIIISVLLSFLKQCLGGPGQDQAIYKRLVRQVWLGSLAGIIICLVIGGAFIGVFYGLGKDIWSKSEDLWEGIFYLIATIIISFMGLALLRINKMKDKWRVKIAQALAEKSAQSTKSTTWLGDWSRRHVMFLLPFITTLREGVEAVVFVGGVSLSLPATAFPLPVICGIIAGLAVGFFIYRGGNMMSIQIFLIASTSVLYLIAAGMFSKSVWSLQYHTFAQRVGGDVAEEGDGPGSYDITETVWHVNCCNPETDNGWDVFNSILGWQNTATYGSVISYNVYWAFLVLTVSCLMYEEKTGSLPLKNQFLSFMSKIPGLGGWVAKKRAKQDINEHEVLRQVQAAGLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BTR4</accession>
    <name>A0A2T4BTR4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1341560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BTR4"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
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        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotidyltransferase"/>
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    </dbReference>
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        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="288"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="509"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1175"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="647"/>
            <end position="660"/>
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            <begin position="722"/>
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            <begin position="815"/>
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            <begin position="830"/>
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            <begin position="1196"/>
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        </location>
    </feature>
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        <location>
            <begin position="1237"/>
            <end position="1251"/>
        </location>
    </feature>
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        <location>
            <begin position="1289"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1300" mass="140735" checksum="FBF899EFE8C99536" modified="2018-07-18" version="1">MDARTQASETQHSYPPSPWTSTTPTTPNGLTAHTPDGSQDSAAAAAAAAATNNLQFSPHIGFLPFLFPQQSIYHAQLLHYNKLISPTRGGGLQSAPLPPIVSVPHVQATSRSRSSSKASLRDSAAATTTKGTANGGHGSRANSGSDKSRAVITPKDVPPKMPAKLAADGPKNFPHRAIARSSSPHGLSHSSSVPSTPHQHARQFSFESREPSPNNVNNHSPRSAYSETNSALPSLRPLPPRLGGCKYETAQMNSRRRIPYSVGSERLEKLDLRTIKSKLSESEEKRLAADMNEIYQKLLPTEKVEENRRKLVNKLETIFNTEWPGHDIKVHLFGSSGNLLCSDDSDVDICITTPWHEMEDVCMIADLLARRGMEKVICISAAKVPIVKIWDPELGLACDMNVNNTLALENTRMVRTYVEADPRVRQLAMILKHWTRRRIVNDAAFGGTLSSYTWICLIIAFLQLRNPAVLPALHQLPYKSTRPDGTVSDFADNLKKIKGFGSKNKSSEAELLFQFFRFYAHEFDYDKHVLSVRQGKLITKAEKKWHYALNNQLCVEEPFNTSRNLGNTADEYSFRGLHLELRRAFDLISEAKLEEACEQYVYPKEEERVWSRPASQPRPVLLRSSSQSNSGRGGRGGHRGGRHSNNYHRSGGSNNRRASSTTPSYDPNMFIQPVTMPQDMSWLAAGNQYPFPFAQQDLMQMAYQETMRQQLNHFYAQAQQSPAYMSHQTMGQQRMSPNAASSNGQQTATDRSRTNSFDTGPIGTTLRPDLYSLYGMGINQQFFAQAATGYGTYPSSPVTSNGMGQDFRRPLQRSTVASDNGISASAGSLRSQSQPPSRSPSGAHSRAAYTSGAGPSSVPGYAQRHVHGVPVPAFVPDDADFDGRSKAASVSPPSEEIRSAGLLGARSPRLGQAPVPQSHSPTANGLGFGDVVTQSSSPRRRRLSTDQLPQTILDRRMRRTSRSPSPLDHGRAVATGTVASSPLASAPFPPAGAAQHKNSNRPLVVNGSGLKTSVIVASSQPPKEAQAPEECAMAKIDNALHISSVPSSNGTIVAEGPGSQPMPALAPAPPMPTAPVDRPPVIVNGSNAKLAMPPPEDASFRDRVAMMGSYPANPYPMPHDVLQANGMAQLAASSKQRLISRQPQNGVIAPLDLAIADHRKPLGVEMAHLSPVYEAQASSPTALRKPDVSVPIPGKAAREKADAKTAHEEATKPAAKAEEKAQPAQDAQKSSKAHKSAGQTQRNSNTQTSRETGGHVRSAKGDNDNGWQRAVKGKKKGSSGLAQVSHAEQPPKSDSERKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUK1</accession>
    <name>A0A2T4BUK1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1433188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUK1"/>
    <dbReference type="STRING" id="983965.A0A2T4BUK1"/>
    <dbReference type="OrthoDB" id="3595619at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
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            <begin position="177"/>
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        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="365"/>
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    </feature>
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        <location>
            <begin position="430"/>
            <end position="460"/>
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    </feature>
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            <begin position="236"/>
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        </location>
    </feature>
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            <begin position="73"/>
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        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB72984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="488" mass="54572" checksum="68AE0834205BBFAF" modified="2018-07-18" version="1">MKASTGVFGEAYASCFSCLTCWEPFAFRLDESPERRDNNRHIRIISDQPLSHPPPMAVPEVELARPSWRQKVQRTFSSGQPGFSSRSRAQRDGTRPQLQISAPFEFRHVDSGSFQFPFPAQRPSRPWESPLTPDTPETPFEPLQLNVLSSGKELSPMLPDFDFPREMTPPSLVHLPGRPFRDDSSPCHQRNTSSPSFHIPRKNVAAPPPPRSPEVSPLQLASHKQTRPRAYTPSDMETIKERVASAMNEVEQLQRKINDIIERQSLYTASRPSTAHSMARTIPEAAEVPVIPALPPAAPSFAERLNTEVSLPNTGPVTASVHISQLEAYEETLDSIRQFSQSRRAQQSSPPPPPPPPPPLPLVLRPPLRKKKSFSRVSTWLFPDSDRARKQSLDSVTNVPRPIKGSEGFYQCVTPPRRPLRQSTETFDTLSTWSTNDGDRTVPSAWSPRSTPSKNEREEDEDVFIDRRATFGMHNVADPAAVNVGVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUR4</accession>
    <name>A0A2T4BUR4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1383198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUR4"/>
    <dbReference type="STRING" id="983965.A0A2T4BUR4"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="290"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="984" mass="108361" checksum="BB76BFE784563B9F" modified="2018-07-18" version="1">MLSASSPIAYPSDPPSPPPKRAKPHDVQYPTQKPRIRGPFVDSDSESDVENLPRARSTSPSKRRRIDDRPVLATRDANQDDGDGIHCERSAVIDLDAAQKASAIDGIQTITPITPHWGRLNPLLTTPIFGSRSKTTYKLKTCGGKEIAIKQRQEAVAQSYESMVAARSKTKEGRAKRDYYGVDIHNLINAATSETAAKRQPPSSPDTNQAVRSMEATSISDKKPKKTMLWTEKYRARNFMDLCGDDGTNRLVLRWLKRWDPLVFPGTAKARPKAARRNGPHAQPEEEKPHRKILMLTGPPGLGKTTLAHVCAKQAGYEVIEVNASDDRSRDVVKNRIRTSLGTESVKNVSNLKAANGPQKVAKPACVVVDEVDGVVTGSGASGEGGFIRALIDLVLIDQKNSSGIEKSYDGKKKKGDDFRLMRPLILICNDVYHPSLRPLRQSNLAEIIHVGRPTLDTVVGRLKTVFEKEGIPCDKDAARKLCETAWGMASGIDARRGQESTVQGDLRGVMVVGEWVASRFRASGLNGTQRLTRDWIEKNILQELASGAAGARGLGRGSVKDIISRLFQEGGGFPKQALNLSVSKTHHEQPKTELGFGEHQKKYAMECLRQMVDASGEISHIVTEIFAEYPHREFNDDSYLSKPNQAYDWLYFHDACQSRLYASQEWELAPYLSQPVLACHHLFASPIRHFAGGGMSSTNNQRSGLAGEEEAGPTVPFSGPRADYQAYEAEKQTRAQLQTLQGQLSPSMMRLFRSAEDVSTEFLPYLARMLSPDVKPVVVGGSQGTTASVRKESERRMVKRASEVLAEVGITLHKGKIESDVVSSRGPQFVYRMEPDIDSLATYETASSILTSQPPARYAIRQVLDQELRRTLALRETNARQARFQAGRSPGEGEQAQPLSLLGGKKNKKGDDDSEMAVVEDGLVVKRDFFGRIIQAQALADVKGGLMEKKAAAGQEKVWVTFHEGLNNAVRKPMTLREFLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVB9</accession>
    <name>A0A2T4BVB9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1340309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVB9"/>
    <dbReference type="STRING" id="983965.A0A2T4BVB9"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015743823" evidence="3">
        <location>
            <begin position="28"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB73252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="590" mass="62795" checksum="CE3E77B66E02F8AE" modified="2018-07-18" version="1">MTTAPIQSLCRLSTLLSIAVLSLGTLAQSNEPLDTKVWAVVAYINHGEKTPTLGGLDNVLTPMGARQMWRQGSAFRNRYLGAANSTLLSNSTENTTIQGISRDAISNNQLTVLSQTDEWVAAGAVAFFQGLYPPTESAFNSFAGGSQMAEDVSSSSDPVDYPLGGYQYPNIETLSASDSASVAIQGTVGCWAWDTNVNVMKQTDPMGRFRSTESLYRSLFATPPLNGTIPKGAINYWNAYNIYEYVNYMNTHNKTVNSGLGFANTTVGVLKANAFELERAMNGDSLSGAPNFTYNNITTIAGQTLGMQIASSLSGATIGSDGSKLTLMFGSFEPMIAFFSLMGLYSGPNLLSGPFSTLPEPGSAMIIELLGHHSGDPSALPAPQEFMVRFTYRANADVGEPFSVYPLSSNSSDSRVIPFTTFLGQLQRFSQDSSQWCSSCRAIFASWCDARSTSSVSDPSSPAGRSSSSLSAPVAGVIGAMVTLGVTGLLALALYFFGVCTFRRRTPKPSVRGTSPGGFKGTGKMASDADVTVTKRGTAHERSGSWELKDGPPTASGAVVAGEEPYLRRSEDDDEIAMVTAEPVRIRETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVC0</accession>
    <name>A0A2T4BVC0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1425191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVC0"/>
    <dbReference type="STRING" id="983965.A0A2T4BVC0"/>
    <dbReference type="OrthoDB" id="5417135at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="708" mass="75768" checksum="938DF8A15DB917BD" modified="2018-07-18" version="1">MSIIRARGVNLAAAGANTRDGDVYKMGSRINLRRSLGSIGSLLRRGDCVATDESNTCEKPVGPSDSTLAIVLGIIIPVILAIVVLYFLHRRNMRRDKLEELNDPTKDLDFGMGDAPAKTRKSLLGLGGEKPMHKGGLSMDMNLSSPYLLPPGHQGSRESIHSYARTLQTEDDPYRTVNQYAASDVGSIRSFNPNDNSGGRPAKPSGLSKPPVQPNPSTPRSPSPDEKSDPFATPTAPKPTHQPSGNAAEVHDVRLPVQPIVPEIETVPPVDVFNADEFEMPDIPAPAPAALKLRQQDGSRGYEQPNSARSSAYTDNGRASTANPADGNVPQIHSPGLDSHEDASQDEPRGRPLSRPPAAQQAGGLGVPQNGNTKRLSVGFRPLPPNDLMESDDPEIRANRIRSFYKEYFDDSNEAPPPMPALPPQQQHQQQPQQQLQQQAPGAPDYYEDYDQGYLEAAAYYDADSNAFVMPYAQPVTRRAMTPPPSGRQGGPMGGPRGPGPRGPGFRGPNGNGGTFSPGPGYGRPRAGSASGPRPDSSASNAWARKQQPKKNLPPPAPLNTLPTPSKLADDSFAIFNAADFAPPTSIRENVAGRSQSPFGERRAFLQPPTAGSQLAGAFEDLAPLPSPHLLRKSGTFTGLDFAPPKKFRDPELASDAGSIRSNQSGMSQAQLQAIRSGAGRVSRLPGDTVFTTAAMEDQLKPSWNVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVX8</accession>
    <name>A0A2T4BVX8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 47 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1424776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVX8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVX8"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="81" mass="9394" checksum="CF6C4C77B86DA8E8" modified="2018-07-18" version="1">MVLQPRQRPSKRSDTIMMLVAIALAWLGFSLLQPVAAMRADYLAQLRQETVDMFYHGYSNYMEHAFPEDELTSLTAFQYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVY5</accession>
    <name>A0A2T4BVY5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1339849</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVY5"/>
    <dbReference type="STRING" id="983965.A0A2T4BVY5"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="79"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB73463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="214" mass="22477" checksum="690B25CDCD905814" modified="2018-07-18" version="1">MSSSTEPQDIPSSSTTSQDASGRQPSAASSSAAQLASAQISLRKTLRQFPDFPIPGIDFVDIMPLFANPDAHSTLLSALELQISESFGANKPDVIVGLDARGFLFGPGLALRLGVGFAAVRKQGKLPGPCVTAEYVKEYGKDLFQMQQDAIREGQKVLIVDDIIATGGSAAAAADLVHQLKGQVVGYLFILEIPGLNGREKLGGAPTTILLENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW51</accession>
    <name>A0A2T4BW51_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_133516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW51"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="176" mass="19915" checksum="D63A9A2393B65CDC" modified="2018-07-18" version="1">MPEAQLLSVQGGGLFRYGLAPLRQQAPHVHPNFRASVRFAFNHDKTSAPGSPSSPSVSGIESDAWNRRERYASSRRPAIYVPIRLQRWWRRGETSREVLLGLVARTGDRESAISQQFTTARGIDFSTFRDRKPSLLGIPSVFFLRSAPLPRLRGACCICRPHRSFSALRLKIRNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW54</accession>
    <name>A0A2T4BW54_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M440DRAFT_67760</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BW54"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="243"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1484"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1492"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1518"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1549"/>
            <end position="1561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PTB73542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1561" mass="174012" checksum="F73B1FEE024C887C" modified="2018-07-18" version="1">MANLYFTHSSAPLKTVQEIQFGLMSPEEIKSMSVAHILYPETMEEGGTKPRDGGLNDPLLGSIDRQFKCKTCTQAMGECPGHFGHIELAKPVYHPGFIKKVKKILEIVCHNCSKVLADESDPEFVAAINTRDAKLRFKRVWAVCKKKRRCENDDRSEKNKDEEFAPGMKPPVVESHGGCGNVQPQVRQVALQLKAAFEVVQEDGPKRKETAPITPEMAHSILRRISEKDLRNMGLNSDYARPEWMIITVLPVPPPPVRPSISMDGTGTGMRNEDDLTYKLGDIIRANGNVKQAIREGSPQHIARDFEELLQYHVATYMDNDIAGQPRALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVITGDANLSLHEVGVPRSIARTLTYPETVTPYNIGKLHQLVENGPNEHPGAKYVIRSDGTRIDLRHHRRAAQISLEYGWKVERHLMDGDYIIFNRQPSLHKESMMGHRVRVMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAEVKELCLVPNNIVSPQKNGPLMGIVQDSLAGAYKLCRRDTFLDKNQVMNLMLWVPNWDGVIPQPAILKPRPRWTGKQIISMVIPKEISLHAPEDKSDSPLKDAGLLIQAGELMYGLMKKKNIGSASGGVIHLCYNELGPEGAMAFLNGVQQVVTYWLLQNGHSIGIGDTIPDKQTIEKVQVHIDTQKAEVARLTAMATNNELEALPGMNVRATFENKVSMALNMARDQAGTTTQKSLKDSNNAVTMAESGSKGSSINISQMTALVGQQIVEGKRIPFGFKYRTLPHFTKDDYSPEARGFVENSYLRGLTPTEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDLNAQYDGTVRNSLGDIIQFLYGEDGLDAMCIEKQKMGILKMSDEAFENKYRLDLANPPDWFRKDYEYGNELTGDKASMALLDEEWDQLLADRREVREINRSKMGEEMMQLPLNIGRMIETAKRVFNVKANDRSNLRPSDVIPAVRNVLNKLKIVRGEDQISKEADTSATILFKALLRSRLAFKEVVKEHRLNKLAFDHVLGELQNRWDRSFVNPGEMVGVLAAQSIGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEILNLAKNIKTPGMAVYLDTPLAKQEQAKKLRSLVEYTNLRSITSVTEIYYDPDVQSTTIPEDLDMVESYFLIPDDSQDTIDQQSRWLLRITLDRQKLLDKEIKIDDVAQRIKEEYPNDLAVIFSDNNADEQVIRIRTIRQDEKDEDGEKKIEDDVMLKRLEAHLLDTLTLRGVPGVEKAFLTKGTRLVEAADGSELALKDDPRCTQWYLDTSGSALREVLAVPGVDPMRTYTNDLWQIIEVFGIEGTRAALVKELTAVLAFDGSYVNHRHIALLCDVMTYRGSISAVTRHGINRADTGALMRCSFEETVEILLEAAATGELDDCRGISENVMLGQMAPMGTGNFDVYLDPKMLETVISDNSRMASPNLHGVGATSPSYSPASPSWSPTSPEAYSPTSPSFSKSPGSQQSPTSPSYSPTSPSFSPRTPGPGASGNQYSPNSPAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BW76</accession>
    <name>A0A2T4BW76_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PIG-U-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1404500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BW76"/>
    <dbReference type="STRING" id="983965.A0A2T4BW76"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="421" mass="46894" checksum="465ACD604EC45D34" modified="2018-07-18" version="1">MTLQSKVGVFAGAALLRLLLFTAFPSLPDLLTGRVEVSTPVTSFKRLQEGLFLYNHNVSPYDGGVFHQAPLLLPLFSLLPDVKTWPIFTALLYILVDLLSAYALLVIADSGEAGQSKHFTSPRRAKRSSGLLVAAAFLFNPYTIASCIGRSTSAFTNCAILFAIAKALSGSPFNSMVAISFASYLSMYPILLLPPLVLLAYDRQSEKRRIDSAVHFSLRAILIAATCISLLLAMSYALAGNSWDFLARTYGIQLTLSDLTPTVGLWWYFFIEIFDSFRAFFLAVFWLHLVIYVGGLTIRLRTQPLAVLTILLGIFAVFKPYPSISDTSLFLAMLALFRHLYPIMRYTYVASATMLYATFLGPAFYHLWIYAGSGNANFFYAITLVWSLGQSLFVSDLTFAVLRDEWEVERPDMVGKEIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWQ4</accession>
    <name>A0A2T4BWQ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_120517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWQ4"/>
    <dbReference type="OrthoDB" id="10646029at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="151" mass="16500" checksum="C9652F98CF915F8E" modified="2018-07-18" version="1">MIHTRSFAQPAGASLLLQWAQTQIHAACLLIFTYCGSTASSHTRSEPAIHQMATIMRRPSKTKTSQQLQPAQRQPSDVTTVSTDIAAQARHPTPMETEVPARRIVPPILNQPSWRPSRLGSGFAFPFSLAAARQILRGCAIGAWACWAPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX19</accession>
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        </alternativeName>
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    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1393700</name>
    </gene>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="146"/>
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            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="21"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="PTB73852.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="76" mass="8217" checksum="026A04538E9B421F" modified="2018-07-18" version="1">MSEPAPTPTITVTEPERVYDAQPKSLPAMNAQQPQPETTDDVKMRGGDDGGMCPGRFCFIIPCPIPCDCCIFPCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXK1</accession>
    <name>A0A2T4BXK1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1432833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Hypocreaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
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        </location>
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            <begin position="136"/>
            <end position="156"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB74004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="22103" checksum="A9B627BF2EFAB77D" modified="2018-07-18" version="1">MSPREHVRLPILGGDGTLSVLARQAAAAAPPAAGNVVYSNDDDEEAQILEAEDAAQFDELGGASPVPEGDDEVDSFFGGDDNDNHHHRVGYRAAVVCWAIAQPPNLDGLSLPELTDGSSLEDTDEDDVGSLGYLSGEDENEAEEEESEVDEEEPNQEEAQQYLLLLDSAMESIVADIEAPDWMNPANDYLLEAYDFPPLQRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY01</accession>
    <name>A0A2T4BY01_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1393280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="983965.A0A2T4BY01"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="75822" checksum="6FF8F3C19523CF8E" modified="2018-07-18" version="1">MPPNAGQQGAPGGMPHQFAGGHIAVSGPGGQINPAMMGGMPPGASPGPHAVHQLTPAQQQMFQQQQQQQHLQQQFNMNNPSAMAAIRQQQLLQQQQQRQAMFAQQFQGMNTAGVNGLPMGMQLSPQQLQHLRQRSAAMGHGPGPQAIMAQQLALQQHAAQQQAAQQAQQQAAAQQAAQQQAAHNQQMAAGHSQAQHMAMNSQPMGMQQQNPMAAAQSQMGAQQQQNQQPPGQPQPPQQQQPGPQSQQAPQQTSQAGTPAPSGQQTPSQTPGPTPAHANQMPPGQSQPQQAQPPNQAQITAQQLMASSMMQQQQMREGMKTRCLLKLMQFGERLSGFPGAKNKDDLSYWNRFVAQFFSPSGVFRHTLHVSDSEDTPDKQYDIAYPAIARYFHTHFSSGVKSMQLILDSGSSDKHLPGDCYCIENPRASFVYWFETGSHLVATGTLRAQFDAEQKIELFEFLTTRQEEYVSRKRVIEAAKPAHEWIKEWRSVNTMDGKQSPEMSKKGKARQLKSPQKEPPGVLVDLPDSAVNSKGVTEAVHQFLEIVEVMGQMNPLFGFYHSNPGLSPYGALEQYVATQINNNPAPMMNGQTMAQGPRTPSFGQFPMGASPAAVHMNLPGSPHIGSPAPGQAPGMQLQPSQQGTSSSGPSANTSPASNKRRRPSAVKVEDDSATAGAAQVNGIQNRGKPQTPRMAKRLKGNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BY96</accession>
    <name>A0A2T4BY96_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1301555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BY96"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="148" mass="16992" checksum="D592A14ACF71BE81" modified="2018-07-18" version="1" fragment="single">LRKANRNKLKTKAKKDWNPATYFIVMFLFIGSMSIQMIALRNQTERYMRQSSLRLAQLREVVHRIQNGEDVDVEQALGTGDPQKETEWEEMLQAIERDEASRNLEKQPKQKRTEAQAKTTSQPQSAPQPPSEAPAPVKTKTATFGNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYG2</accession>
    <name>A0A2T4BYG2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1464374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYG2"/>
    <dbReference type="OrthoDB" id="5304511at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="60995" checksum="3094AA957DCD4221" modified="2018-07-18" version="1">MLPNVHTYMYLNSSPDSPKPIPPGTRVFQFYGICPKRRRCLRPAFDEMIKKLKESLTRSRQPQSSGPTMTRTTFNDLCPEIVLSIMEKLPDVQSLKSLVLVKKKTHSIFTNHKKGVVLHSVLENELGEDLFVHALVTCHVEKVPIMLPAFPQLTVTSIRDQVGQLRKIRDDAAALQKAIPIALPTFHPRDTAMRITLRDADRMSRLWSKISELTDVFVEDCRLGVSLEFYPMQDSMMRRSVSVTERKRVGHAMYLFHILSIFCKKLYLDVERTPQGEIDADRLNDSLEKLKYLQLTIVLRFMAPWEMYELVSLQAWVRRALHDLEDDCYMSERLMPYLLVQGLDRLHGCICGSAGNDEALRVSVLALKKEASKHKAHGFGMILSRGERSSWARRPREYEKYRPFWGHGSRDRGGYRSWRNLESPRWNHAVLDPSVPVALELLGIAQGMLDVWSAALWDPARWSDIRRTMRDSMVPDPWGLIACHWDSYMVGWRSALEPGMLPGVRKEAKLRVFLRWARGVLRLRRYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYV2</accession>
    <name>A0A2T4BYV2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1464435</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYV2"/>
    <dbReference type="STRING" id="983965.A0A2T4BYV2"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB74406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="259" mass="27590" checksum="9CCF0CDBE3A73E59" modified="2018-07-18" version="1">MSEHSPVAFAPPDNVTGRSSDANSSMPGSHDGGLSPALVESIAGLSAGTIATLVVHPLDIVKTRMQISTSAASAASQNLSTVGLLRSLSSNPKPLSSLYRGLVPNLSGNALSWASFFFFKTRFEDLLTFARGTPRPTPSDFFVASALAGAATSVLSNPIWVVKTRMLASDKGAKGAYPSMWSGFRTIYATEGVRGLYRGLGVSMIGVSHGAVQFAVYEPAKRLYFARRRRMGRIGLGHTQITTTLITRPQPQLHLCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYW4</accession>
    <name>A0A2T4BYW4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYW4"/>
    <dbReference type="OrthoDB" id="10576706at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="95" mass="10231" checksum="18291EDB03682A8C" modified="2018-07-18" version="1">MTAQGGEKSIITAVGLGGKRSALWHRGPITLCFFIFLSAVSLPHLSFTNSFFLSAPCPLTNPHCSAVGPPAVGHNKPLRPWLPRLRCGDLPALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYW8</accession>
    <name>A0A2T4BYW8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1439983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYW8"/>
    <dbReference type="STRING" id="983965.A0A2T4BYW8"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="322" mass="36104" checksum="6767352E350F9E08" modified="2018-07-18" version="1">MRGPPIDQLVYEHMFPKPKTFDPQDFSALLQRSLIPEVRQETHAFYGHLDTQEAKYPGLDYTHPTHRIRLSRWQWHRRLFRAFDALGLTHAEISSLTKWEGTKWAKEKFEAEQGIVIRDTAADDMPDWTEPAARPSTQPARAVRISTLALPSLDDDDNMDVEESDEELASVGVPLNERLRAQAARREAGDTSVVLDEEWEQWLKNAIDSGELAVLTDRMTAEMLGQSHSSGSGASNPLSDRMLHRARAGQWSEIPEILQPLLRRTIDNENSIRSGQILISATRSTLQSGLSRSSSSRRNYSNLRLPAGDTPTSQPGARAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYX1</accession>
    <name>A0A2T4BYX1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1337175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYX1"/>
    <dbReference type="STRING" id="983965.A0A2T4BYX1"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="97"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="189" mass="20118" checksum="2B98BA2441998F05" modified="2018-07-18" version="1">MPPPPLPSSRPNGRIPALSQFPAPNSAQRARGPTPNRGPPAASSSSSSGLAPPPTHSSKPAKPSRQVVLTPGHSPLDWARISGPNSDLRGVPASTPYLRVTPSMLKVQTGRKGKDAWMAINGKVYNVTPYAKFHPGGVPELMRGAGRDGTKLFGEIHPWVNYETMLAACLVGLLVDEPEGKESEMDRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZN5</accession>
    <name>A0A2T4BZN5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1380173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZN5"/>
    <dbReference type="STRING" id="983965.A0A2T4BZN5"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="622" mass="69208" checksum="5B24396171BAC4C6" modified="2018-07-18" version="1">MSSSRQPQPRRSSGRTLLACEPCRKRKSKCDGEKPVCGSCQSHELACHYEPVRPTRRQKYWDRDYVQALEDQVRLLSASLQQSKDSSASASASASPASQPSPASSGASKQQQPPPQPLPYGPKMLSALHDFGSVKWADVTGRDGLPMLAGPGRFSFFSHTLLPTFEDGSSTPSPPPKAAVPSTETFLLDIASDLRLKQHLKAHFLEHINPYYKFVDPAWLNFSDLFPHNDTALQLLYGALFAAAAYSSPMASREVAEAFMAYAEGLVQQCYLEHLCLPVLQALIIIAWYKHMLLDAAKGHLYHYMAIGLSNHLKIRDTPQHERTVSDIATIRTFWSLFFFDRVATPKLGCPTGIPWEPDNITPYIDTVSPEMVDVEALSFDHHCRLYHVQQRYIDAMYAPNFHTLPSPEKQALYAKANSAMLALRKQIDRRLYISRNSKPRRVQVVFWITYHSILINLHRPVLDPQDADMAHNIPSALRSATASAMAVTRLLKGLQASSSPPGGEEVKLLPPFMIYHVFRAALVHGLNLIAAEEAAGGQRMSSGNFWTCFRVLGELSGVWKELSEGAMPFVLMATRGWGFQEEVMGVNKAADEDDDDDDDCFEAGIDDLVGQVEGGQYERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BZW4</accession>
    <name>A0A2T4BZW4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1464165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BZW4"/>
    <dbReference type="STRING" id="983965.A0A2T4BZW4"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="174"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="41666" checksum="2E7A07CAB9B50267" modified="2018-07-18" version="1">MDSYDKQGLNEDDFGAKGSIVSAFDAFPKAKPQYVTRTAGGGKWTVAMLLVSSIFLWSEIGRWWRGAEHHTFAVEKGIGHDMQVNLDIVVKMSCGDLHVNVQDASGDRILAGDKLTRDATSWEQWVDAKGVHRLGKNENGKLDTGAGWHGAHDEGFGEEHVHDIVSLSRKKAKWAKTPKPRGRPDSCRMYGSLDLNKVQGDFHITARGHGYSGVGGHLDHDKFNFSHIISEMSYGPFYPSLVNPLDRTVNTAIVHFHKFQYYLSVVPTVYMTSNRIVNTNQYAVTEQSKTISDHQVPGIFFKYDIEPIMLSVEETRDGFFAFLLKLVNVFSGVMVAGHWGFTLSDWVREVIGKRRRSNGGIGMLGNKHEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C046</accession>
    <name>A0A2T4C046_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1380614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C046"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="62"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB74938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="459" mass="49291" checksum="FFF87A0419B29984" modified="2018-07-18" version="1">MGLTQPATTGLSSTEVSSTDDVAYEPKTETNPPRPQSIPSVEAQPTDAAVTIGPPPDGGLRAWLQIVAGHLVVFTTWGYIISFGIFQPYYMQELNLEPSAVSWIGSIQTCLLFVIGTFTGRAFDAGYYRPCLISGFLMQLVGIFTTSVASTYWQLFLSQGLCQGLGCGLVFAPTIANMATYFSKKRTLALSAAACGGGTGGVIFPLIAQQLIPQVGFRWTVRVMGLVVLVSSVIIVLLVRPRLPPRKAGPLVDWGAFKEMTYVLFAISMFITLWATYFAYFYARAYSIDRLGGSQATSFNMLMIINAVGIPGRLIPAFLADRFFGAVNVFIPTILSAAVCIFAWSGVNSITGDYIWVIFFGYFGAGIQGMFPATTAGLTKDLSKSGVRIGMIFSIISVASLTGPPLAGKLVVVAHGSYIGAQIWGGVCLVIGALFLIAARWASKRELAREKEEQSSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0X8</accession>
    <name>A0A2T4C0X8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1358161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0X8"/>
    <dbReference type="STRING" id="983965.A0A2T4C0X8"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07931">
        <property type="entry name" value="CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="261" mass="29067" checksum="60ADED9F2829EDDC" modified="2018-07-18" version="1" fragment="single">MPPKRALIVALSGCSSSGKTTLARLLRDIFPNTFILHEDDFYRPEAELPIKNGLVDWDCPESIDIPAMAQALSYIRENASFPPTLDSKEDQNSVGPSPIPPSLTSHLKSKVLSHLPPSHPLLSDSSSTTTAATANLKICILDGFLLYTTAMSPIQPLLDLKIFLRASYAKAKARREARDGYVTLEGFWADPPGYVDQIVWPNYVESHAWLFEDGDVEGRFRRDVLEREGIRVPEGEPLDGDMEATLTWIVDLLLEELKKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C108</accession>
    <name>A0A2T4C108_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1379202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C108"/>
    <dbReference type="OrthoDB" id="2992173at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1373" mass="153034" checksum="787A0251B60A76AF" modified="2018-07-18" version="1">MPSPDAKAAATVVVPMAVQAFIAADDFGDTAYQMAPIAQPDLHKLQRLQQPERYANQSAIEGGGEWDHLDLMDWVDTSWWRLQAEYNQRFRDLAAGGPRKSRSGVYLSWCLPSVYRSAITATESTIKTPQDRQAFEERKLRSGYRVTDNDGNPIPSERTQFRAAPDRWMVFRKLRSGGNGEAIGKEKWFMVESNCLRAIDDDELLDPNAPDIEITTSAGIDPDDLQPAILEEKEPPKPIRMGRQVELNYKSLIAKNDRKHRVPFNAFEMGHEFFVDYQPHNMGVFSLFDDLKDWVNDGGSATFDYAIVGYHEDSRDDPLMLDHPLPAGKPPLKNRDIMDALELVLDGRKDDDPGKDGALQFLNAEANKDGRTFTYGVLRNVRFDRNSVRHLDAPSIKLQEDIYSHQPIAVGLDTLDALGAYLHVALNGSTSRQAQNLLSQLVMLVAREDDVDTQRKAADQVANHSWIAHKEGTLWHFPDKDQWDQKTPAVTDEHRIALSKLNNVQAQLDACIREEEQLLEKLYSCWWNAMGMRNLPTNVLTLRRERIRNEATAISSRLLILSDTKKALQVDIERKRLALESMFGGGSKRTKLITIPTPGFGRHQDPVALLAGAKSGWPADFSKPLPVRLASEIAVGQPPCDWQEWIEKFMANVGEPLKAILREFSEPDDTKRREGNWRKSPYVGIEDMKNTQGWFPLFIEWEIEYYHIPFSNWEFVASDDDSGRWRWIIPEEKRLALDPGAAKDRRRIRGRTAFLPQAALMLRARLEQLFAQTTDKEVLARKDEVLNKLSSLEYFSAPLAGLADHLLTLRHGANHRPSAASCSNDDVIKNILGLNTDVLTRIEGLAPEVAPYGASATAVSPPEYWLNNSTAFKPVMHGQARFTRLVVVDKFGQIVSGLRPTVYGDNGEGESSALYPCLSPSLTCGGYQLEDGPKGHYWPNTVIKADNDPNVCQFFQLPPRINESARLNVRYMMPGGAIRRSATEWDNPIWAWLVTNFQSHSIQVYDGEGHFMQEVVIVDNEDAAKRRVVFSMGPRSGGHAPTATGRLAELLESLKDYEFAYSVFDMIGGAADGNWRSSSANLDGMLPASFGRPFCIADVGISIELAAPALSDASLLSKPSTSGEPASVLDYEFPIAMGNHTAAFDGLVGTFPSNGPITTSNLSTAYSRWASQLANSPKETYTSTETRPRPLWVKPYFVAGDMGGVDGVDFAKAHNEQLSQHCVSAIIDAKLPIHLYSGSLFPMVELSLPRWPVDQAMGNMQAFFAVGPTLVPEKPVMEYRIAAAPGGDVTIPKELSIQMPAAGDADNSWRWMQPRLDGFDPDANDDDEDEGYPPIGSTEWDPALIKPLDKTLKVEDAAFSEIVEGYIMVKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1M0</accession>
    <name>A0A2T4C1M0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1335669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1M0"/>
    <dbReference type="STRING" id="983965.A0A2T4C1M0"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="391" mass="44107" checksum="38CC4795A3CD063D" modified="2018-07-18" version="1">MATTTTVTKRGGGAVASIKLPEEDSRFPDINTIRAAIPKHCFEPSVAISMGYLVRDVVMIGALGWAALTYIPTIPDATLRTIAWIVYGFVQGLVCTGLWILGHEAGHGAFSQHALLNHVVGFFSHSALLVPYYSWKFSHHRHHKYTGHMEKDMAFVPRTKPDYAKRTLAALEMLEDTPAYQFVTLMFHQLFAWQIYLLFNISAGRNSLQKSASTMFGKSHFGPNSAVFRPSEAPFIFLSDVGLAMTAFALYKLAGVVGTGTMLLVYAQPYFWVHHWLIAITYLHHTHLEVPHYDAENWTFVKGALATVDREFGFVGRHLFHCIIEHHVVHHLFPRIPFYYAGEATEAIKPVVGDLYHRDERSFLGQLWSNFTKCKYVVADEKTPGALHWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2H1</accession>
    <name>A0A2T4C2H1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1402287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2H1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015530811" evidence="2">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="115" mass="12388" checksum="0406886A0E4AEC9F" modified="2018-07-18" version="1">MFTYGSGMLFVVIGLSGGPAGLISLSADQLLNQLSSLPRQSDLSSTPREDTYDKYDFSATQSHLIEPCNTRSNSFHLMSSREKSDWTAVAQCLSPPALSPPAPSPLMQPIGIARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2R1</accession>
    <name>A0A2T4C2R1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_5337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2R1"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB75849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="21146" checksum="D21443EB6ED53C1E" modified="2018-07-18" version="1">MDTPLEDDEAAMAQAMGFSSFGAQNRPQKRKYNPHADAVTSSDSATAQRAAAKPSATGSNSTPLGVAARKKPDPAANADEIDLDDDEDQEKDQDASLDNGEDSLKVSAAISEEPDQRSAPALVHPPGLPSRPPPGVGAAGSSSGGHHRVNHRREDDDSWSEGYYDPQSNENPWRRLEESLGLQPLGTWLAPGHRASARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2S7</accession>
    <name>A0A2T4C2S7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein required for cell viability</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1463477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2S7"/>
    <dbReference type="STRING" id="983965.A0A2T4C2S7"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="556"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB75862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="904" mass="99599" checksum="879027879BBB4664" modified="2018-07-18" version="1">MMAESTKSQRTQPKITQDIVDAAKRAFDPSTSPESRRDGLREYNELIERTQTWILIHVLNALIKPNVLPPWLREPLMRTLTQLPLRPDGVRATMEFVFAVHPSNTGKPAEDAASGKQGAAITHEAVAVATKLLSSVPATMSAQQWFVGISGQLFALFDGEAGPDVAKTAAQIVGFGILGKKQFGAPGAPGWGAFVQPLIEAINPSLKSPKKDSSDDGEEVVELGRERVLVAASDLERALKRLELLIMSNPSPGLCKRVLKPVRLQLWALASWINPSQETDRRFCRPARILVQTHLRLFGDVDNIVPFIRNIQCKGSLIGEEGLQWRYRLASDGGIESTQRPFAQQDQEVDLDWGENEHKSTTLVEFISSVCATEEVSSVFLYLLRRWIQTAGKQSGGSIIQVVTQDEDANSTVQDLVDVTLLQKFMDKAPEKLISHFDQLLELISHVLRADSQAPLGDDIIAVVLSLLNLVITAPTFQKSDINPAELEVVEGALARIGREDRGEASTTANNLSMLLKYRDDVEKPDDKTAAPTARQIEDRRTYNLAMNYITGDGNPPPVVSEGLNLLSNLIVAESSILDIAAVTVLMSNLLKENEDFINLRVIKIFTLLANKHPRATMQELLDNYLDAQERLNTDTRLRFGEAILQVIERLGETFTGEVAQNTGETMLSIASRRGYRPKTMAKQAREERLNELKRKKAEANGEVDDDIDMDDEEETPEQAANKEILAQIVQGWESKRGSEDVRMRTSALSIFGNAIETNIIGMGPTLVSASVDLSINVLAMEPELEKGILRRAAILVILSFVRALDKAKESGQKLGFGLTDQSRDDIQRTLQYIAATDNDGLVQQHARDVVESLENWGVASLLPSQAEASAVPGLTRLAGLHVNPEGNLVDASGRPRPRIEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3B8</accession>
    <name>A0A2T4C3B8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1333366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3B8"/>
    <dbReference type="STRING" id="983965.A0A2T4C3B8"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="439"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="921" mass="98055" checksum="A04C91D11B72C68F" modified="2018-07-18" version="1">MPASRGSGGVSTSSASASVSLPWFPGASTAATPPATPAPAPAPAPAPASAGRETGDSAPSSPSSPAPTPASPSPSPAEAQPQRPSAVTAASHSAPRASTTASTSASPTSASTSTPTSPLPPASTSSSSGTQSRPGLLARLGSSLNLPLPSPLRNRNRNVTDFHVLCDEPHRKYSAGDHVHGTVILVVVKPVRITHLVVTLHGFVRVLRDPAGAAKVRNAVTLPQGGSSSRPQYHGNGFASLFQDEQVLSGEGRLDPGRYEFGFDLVFPDKGLPSSIDFERGTISYMVTATLTRPVSMAATMTCERKVMLAERIDVGLLPPPPPRTIFLEPISKRTKRKKSSMALDKGSLATPEPVDVVPEPDTREPYPTPTATEDASAREYPISDQQSERRGAAASSDVQSEISGESGRSISTAMSRSDTAQLTQIGSTGLTTAQQAVNDKTITASIELLRGGCLPGDAVSVRVTVQHIKQVKSMTGVIVTLFRQGRIDSSPPSQLFRDMLTREDARRLQREDIYPRSRTGLGGLSLSSAGSISVFRKDLDQTTAPLIIDPNTMQASVTVPVKIPDDSFPTIKGVPGDMISFKYQVEVIVDLGGKLSGHFPSRKTSRFGGTFSSSATDQSISMFSQRRGAQIEIMDTAPLRRQKGIVCVTIESIVGTVDSSGARRLIKLSSSSKTLDNGESDDELSFIPTPTRYEEIDRHNSHSHRLPPQEYFPPHTNQRRPSHSRPPPSHPSYTQLNHHELAPSYTPPPPQLPDQSNLSEKDRIRQAEQRLLPSRPPAGPSSPHEDDIYDAQATPRPPYAGNSGEEDNPCPSAPTEEELTAAVSPLADAGEDKQELERRRLMQEASAPPEFPEDMVRRGGPGRAPREEDLAVDAEPTAPMLDEDGDHSAGYGAGAGPSGSARTDGIREHDDGEQLPAYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3F4</accession>
    <name>A0A2T4C3F4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1438854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3F4"/>
    <dbReference type="STRING" id="983965.A0A2T4C3F4"/>
    <dbReference type="OrthoDB" id="9987011at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="218"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="304" mass="33908" checksum="363ECDBDB1B89869" modified="2018-07-18" version="1">MSMSIAPTETITSLSLIPDLNDEPPREERPSEVDLLKASCIVRQRPISVTLDGTAVFAVSLGVVLAIHFLEAYLAEAIVSLIPIALLVHNDYRNFLSLGPGGTPSTIQGYLRITWLRMLSLRDPFTAPPPDPNREPKAGILSGHHLPYRAGPRPAVAGIAPQRQLDQHGSRQCYIALRRAMERLGARNPSKFGTERSCLEKHGLALFARHPLQTTCQGEICHVHDSDHSMHLCLHPDDIKEILQKGWGQRHPLAWKGRFFQMPVSQDFVMIYAPRNDMELEIVGKIINAAIWYTLAEEVDINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3N9</accession>
    <name>A0A2T4C3N9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial matrix factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1333347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3N9"/>
    <dbReference type="STRING" id="983965.A0A2T4C3N9"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="125" mass="13540" checksum="7255369BE4867881" modified="2018-07-18" version="1">MADQTIVYTKDAPFPLGPYSQAIKTPTAIYCSGQIPLTAEGTLIEGTIAEKTRLCCENLDAVLKQAGSSLSKVVKTTIFISDMAHFAEMNGEYEKFFSHKPARSCVAVKTLPKNVDVEIEAIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3W8</accession>
    <name>A0A2T4C3W8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1422344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3W8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="128" mass="13844" checksum="F3FE0C0A70B759EC" modified="2018-07-18" version="1" fragment="single">GGRGRALRRCEAGRSGQLSSLEVRRDASVIRGLGDSGVPVLSDSERVLAAIGDISWAPAPGLSSSMTTASPKAMPLSPRGLSMVRLTLLLLLLLLLLLRLVLKLVSRMHRALTAPIYHFRPFGRQCWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C478</accession>
    <name>A0A2T4C478_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C478"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="223" mass="26151" checksum="9393F3DB28F57FE6" modified="2018-07-18" version="1">MSCKLNIRVEIAREEDMPRCMELVLDAFGPFPNFDIIGGPNTEENRKLTAERHLRGYREHLEKYPSVSPGIKCVHTDPETGEEKIIGFAEWFVYDRERTEEEYMMENYILRMEWIEDEAERKRCLDGMAQEFAMRRKLMKGRPFALLCYMCVDPGYRRRGAATACVRWGMERCAELGIPGYLEASEEGRRTYETLGWEVYEGDGEVGEMMFPPMVWWPANAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4F8</accession>
    <name>A0A2T4C4F8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U-box-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1333469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4F8"/>
    <dbReference type="STRING" id="983965.A0A2T4C4F8"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="215" mass="24628" checksum="B977D18F5F6A1A80" modified="2018-07-18" version="1" fragment="single">ISDCETCLALSPNNMKAHYYLAQAQLSLRDFDAALANALAAHKLCAANNDKSLAAVTSIVLRCKKERWADREKKRLREERELEDRMAELLRKERDEMLAAVAPEDEAEKKAIEEEADQRLNALRSVFEAAREQNQKKREVPEWAIDDISFNVMVDPVITKTGKSYERASIMEHLRRHPSDPLTREPLTPADLRPNLALRQACEEFLDKNGWAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5J2</accession>
    <name>A0A2T4C5J2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1430609</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5J2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5J2"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="12">
        <location>
            <begin position="108"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB76836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="508" mass="55817" checksum="EE11FC377A1474B4" modified="2018-07-18" version="1">MPSFLADSISNPRIQLLATAAASGAAVAGLIFGYQALEREERLSELKSSIPSLSNDNGRSGRLNSFGASSESGLDPEDARNIALARRAQAGDFDEELILEQLARNQVFLTPEGLQKLRDSFVVVVGCGGVGSHCTAALARSGVSKIRLIDFDQVTLSSLNRHAVATLADVGTPKVQCLYRRLIAIAPWIQFDLRQEKFDEHVAEAMLAPWKEGGRKPDFIIDAIDNIDTKVALLKYCYDNKLPVISCMGAGCKGDPTKIVIGDIGTSKDDGLSRATRRRLKLQGITSGIPVVYSTEQSGEGKAELLPLPEEEFQKGSVGDLGVMANFRVRILPVLGTMPAIFGLTAANHVILRITGYPISYVPGKAREKMYEGILTYVQGSEEKLARLFVPDTTGLKTPLTLGDVAFLTEELYNGRSILSGIPTRLVLIRWEKPETSSMTVIGEGKDEQKCSTIRLRDLVCMTKEEATRHEKEVFKAGKSVEELYDAETIQRVEEKMKEAEKYEWFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5W0</accession>
    <name>A0A2T4C5W0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1456580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5W0"/>
    <dbReference type="STRING" id="983965.A0A2T4C5W0"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015424619" description="Galactose oxidase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="859"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB76951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="95298" checksum="A310F8CE271F8027" modified="2018-07-18" version="1">MAVSPPEPFARGRAHPHRATSGRAPWCRFLGTAALLLGAPLAAAAHSFPYVPTQILAPDACFNRSACHGSDLAYIFTQDGDDNVQFLALNISSIVGADAKLSPVTTSIPFAGGDNPKNTAFGAVRTEEGAVLVYAGQCDKGPGSVWTYGEGAASGGSGDAAWTKHATTLGKSQKGSSSRGPYFLGGTLAFSTTLAPLLDEPTIYSYGGMCDTPSDSSKGWQSAANYSTSMLALAPTDSSPSSRSYAQGIAPSSGPKTPIAGFSLTALQSSMSNISGTVTQQTAYVILGGHTKQAFINMSTAAVWNLPEESWSYVNVQQSTDSPDGVESRSGHTAVLSQDGRSIIVLGGWVGDVTNAAEPQLAVLEMSQAYSSWRWTIPKQQPDFAEAGIYGHGAAILPGNIMMVYGGWQIKNADPSSKMKRQSGITTTPQFLNLTDMTWSTTYSNPTPPETGGQTPEDAPDKASDAAKSRVLGLSLGFGIGGGLILFILALISFFCWRKKQRRRAARDETIRAMAQDASMFVHDGVDMTERPDTFPWGYRSWYNGGQDPYRSNGDDRSSGYESMRGSYGGYAPVVPGVVRKPIARQIRGGYVPANGQLNSIVHTPGQIHPIMEDDEEELSYQRANPAEATTPTSDAYSDPFMTPTAAVASGALPVFQPPPPGQSTAGPSTDGPFQHDPDVQDWVSDVDVADAMLARYNSTRQQGRSSPTRRSSQRSSGMHEDDLHMDSGISESTRSAGDGLGRSSSGRWSAIVATAGLFGGSSAPTTEPGKPGSSSSSSYNTAKSGFGALQAEGPNLLLGRTTPGSPYEDDELQQPSSPSKSKPPRRSWLGSLRRLYPASEEQCRQWWLSLQMVDRFESFGSESKESSSPSVSRAGTPAMRSVKSKKSLRSEDLKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Z0</accession>
    <name>A0A2T4C5Z0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1332295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Z0"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Z0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB76980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="327" mass="35921" checksum="DB3EC18AEB49879E" modified="2018-07-18" version="1">MVREYTKDTTASELIKDLAGEIANKTILVTGVSQGTLGGIFLQYIAEANPSRLILAGRTLSKAQQTADTLKAAHPDIDVRTLQVDLSSLAAVREAAAEVNSWEDVPHIDVLVNNAGIMAVPHQVSVDGFEMQFASNHLGPFLFTNLIMDKILASKTPRIVNVSSSGHRLNPIRFFDYNFRDGETYNRWQAYGQSKTANMLMAISLAEKLASRGLTAFSLHPGTIVTHLGEHIDFSVEFATLAAADRLLGNAEGWLTGFDFKTPDRGVATHIYAAFEPSLKDVNGVYLEDAHIAHPYTQTVKPWGTSKVEADRLWKLSEELVGQKFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6H9</accession>
    <name>A0A2T4C6H9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1437751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6H9"/>
    <dbReference type="STRING" id="983965.A0A2T4C6H9"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="128" mass="14079" checksum="7F8285D7FC41B731" modified="2018-07-18" version="1">MTACIFCRIIKGEIPALKLFESEKTLAFLDIGPLSKGHALVIPKFHGAKLHDIPDDQLSEILPTIKKLVAATGATDYNVLQNNGIIAHQQVHHIPKPNETEGLGISWPSQSGDMEQLKKLCEDIKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6P4</accession>
    <name>A0A2T4C6P4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1374205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6P4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="255" mass="27710" checksum="C9F857581DAA7315" modified="2018-07-18" version="1">MPAGAPGASSRGRGGKFRKFTRGGGKHFSRNLQPIDSEGNAVSMWGEDAQLNKEEDDSEEESEEESEEESDEEEAGGSKSAAAQLAADANREDRKAQKKARKEAAIAKQKSRVVEVGDMPSSSDDDESDAGLPANPNHSSKARKQASKAATADVDAITEGVKKLPASRREREAAEAAAAKERYMKLHAEGKTDEAKADIARLKAIRAQREADAARRQAEKEEKEERERERRAEIEAREAKLRALAAGPKKSSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7B5</accession>
    <name>A0A2T4C7B5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1400348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7B5"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.390.10:FF:000002">
        <property type="entry name" value="ACR027Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="481"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="645"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="882" mass="94762" checksum="D0CD7B410F49936B" modified="2018-07-18" version="1">MRQMILGHYALLKGGLEVDGNLISNIDEREIKEQCAIIREKGIKSVVINGVFSPIDTIERQEERAAAIVKAELPGCDVVCSKDVANLGFLERENAAILNASILSFARKTIKSFQEPIKRLGLHCPVFITQNDGTVLSGEMAAKLPIRTFSSGPTNSMRGAAFLAQGQISEAVMVVDIGGTTTDVGLLHANGFPRQQAAYSDLAGIRVNFSCPDIKSIGLGGGSIVRKTDRGLTVGPDSVGHKLQQEAIIFGGKTITATDCMVQADPGLDIGIAELANKILTDEELTLFKKALQSKIEKAIDKMKTSPEDIPVLLVGGGAILSPNKLRGASRVLKPEWSQVANAIGAAMARVSAVVDTVKSTEHKSNAQLLEEISKEAVEKTVSAGASRASVEVVEQEALPLQYIAHKTRFIVRAAGDFDLEKIQTQDVSGEDDEDNVNDMSQYGRLPKRAETTSKHHTDIDVDISTYRPTVKDRVWYISETDAEWIATGCYILGTGGGGSPYSHLVRLKQELHKGAIVRVVNPHDLADNDQVGCGGGVGSPTVGIEKLPADELLEAQTELFRVCPNPATHMISIEIGGGNGLQAMILGASTNMNLPAVDGDWMGRAYPTKWQTTPVVFNERSPIWSPIAMSDGNGNVVVMPKATSDLAVERILRAALAQMGSHTGCAESPVTGAETKRWVVEHTISQAWRIGRGVARARKENRVDNVAESIIEECGGSGTGRVLWKGKIVGVERTLRGGYVYGECFIEGVDVRQDDDGLQQDGAVSPSFQGRIKIPFKNENIAALRVREDGQDEQQEDVLAIAPDLITVIDAQNGEAIGTPEYRYGLLVVVLGLAASDKWTGSQRGIEIGGPAGFGIDHLAFRPSGAFVKPRSVIDEFDRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7L0</accession>
    <name>A0A2T4C7L0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1215272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7L0"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB77535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="14538" checksum="E36B44F5E580ED01" modified="2018-07-18" version="1">MFAARYCAVSGTSIHIPWLPLCKPPSHKRHRQITSSAILNQTLAGGGLDWAGTGDWGLGDWRLALGRHNDGRHSCSKGRGCDSTRGLDRGEKLSRRSATVDAKPLPARGAWDVDARTKTSRAVSPVRLFVREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7S5</accession>
    <name>A0A2T4C7S5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1438100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7S5"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB77605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="621" mass="69338" checksum="8E8D9D131086C9CF" modified="2018-07-18" version="1">MSSDQSPRDLPRPKQRRISRACDYCHRRSIRCRPAEDGTGCQNCRDFAQTCTYHRKPRRRGVPARGSGGAAANRDAVEGVLDAKSSRSPSLGGGDLRIIPEIQHPGPYANASPQSSVAAWRAPYIVSQATVVDLVELYFEMVYPIFPFFHQPSFTRKISRAEYNTNQPLFATTMAVCALVGGRVRDGSVMNPRWDVQALQRETLPDTFYAEARRQLLEFSVESSDFNILRAHAIVAIAAIQNGKVRDMHYHLGIYHTLMAMDGLHDEANWPSGIGIIEREERRRMFWSIYTLDIFTSVVWSGVIRSREQQANVAYPAEVDDQYISDGGIARPGLSPSGLGPPIARLVLTAQSDCWLSGWNFITDLYRVLEHALARFRERRRSFMSEIIDDQSTVTGTSVRDKVLRMYLNLPECYKNTPKMTFNQKQDLFGFQAANITASLQLLRITLFAAGGASIAERCDIAADVVDAFNSIPVQYCLTISKPLLHHLGGIGAILGSVFEEPLSEAEYSRVRSVMLAMARLLENLETIHHSSSASEKLRSQVSRIDEYMSAQRQQSRPAPEETPVSATVQQVVPIGGSRGAGRAYEQPRVNPEVAGDWSFQVPPDLLGDLTWNFDFGSVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7W2</accession>
    <name>A0A2T4C7W2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1330751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7W2"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22368" checksum="91A63DDD15948179" modified="2018-07-18" version="1" fragment="single">VIPSGIITTFSATIINSIFLTPKKSALLNMPAGAISIFATLAGTYVIYYNLPRWLSIIGLLIPTIIGAGLMSFAKSNAGALAGVYLINFDVAPLALIYALVGANTQGYTKKVTVNVVIAIAFSIANIIGPQTFQDKDKPKYLPAKITVLGVAGGSIIVTILLRLLYGMRNAKTAAARQAELEAIRRGEIDAKAVDDDQTDLTNPTFQYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8A8</accession>
    <name>A0A2T4C8A8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1462378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8A8"/>
    <dbReference type="STRING" id="983965.A0A2T4C8A8"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="387"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB77809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="645" mass="72864" checksum="17481623860C0EEE" modified="2018-07-18" version="1">MKLSNPGTVPVYTISGASTARPLPDWLARRRKRSLKNDVEYQNRVELLQDFEFEEASQCIRVSEDGEWVMSTGTYKPQIHVHNLPQLSLSFARHTTSLNETFVLLSTDYSKSLHLQNDRKLEFHTPMGCHYEVRIPRYGRDLVYDRHSTEALVPAVGIDADGKGEVFRMNLELGRFMKSYQIEVGGDDELGGGLQGGINVGSVNCAAIAEDTHNLLAFGTSIGTVEFWDPRSRSRVALLAGHDGGVTALDFHFSGLSLATGTSSGMIQLYDLRRPTPLLKKDHGYGFAVKKLIHMTTASQEKKVLSADKRIIKIWDEATGDPWTSVEPVVDINDVAWCKNTGMLLTANEGKQQHAFFVPQLGPAPKWCSFLDNMVEEMAEEARTETYDNYKFLTLPELKQLSLSHLIGKTNLLRPYMHGYFVASKLYEQAKLITNPYAFEDERQKRVKERVEKERASRIRGTKKVKVNQKLVDKLLKKQENREEVDTNAGILGDKRFTQLFEDEEFLVDENSGEFKALNPSTAVQQAMEAKHGTTQFQGKDSDEESSDADEPISKPKDDVVMKVSSTQNEGRQVRDSALGSRQQKSTRANKAQFGEVRGERQVTFVPESRKKKPHQEQEEEEAPPPQKRNNKARRSASSNTFRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8M5</accession>
    <name>A0A2T4C8M5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleic acid-binding, OB-fold protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1226157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8M5"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41041" checksum="077815A8E77056B5" modified="2018-07-18" version="1">MPALTPAPSIILFAGAPSPASFDPQSCTLSHFGEPFRSFFGHLDLEIKHQLQQQDKEPASDLGFPSQQPHAVWRSVPLNRRPLHTGLSQNHSILFDASFQAHRDFFTTADAHSVDETRPLDGADEGGALLMQFCEESLAAHNLVPSSQLQAGSLSMDTTGGTTTTTSFVTDSSNDVSLQDEAANRPLPTPVPSHLSDLEDVPSAKRILALAPQTVTLNLIVAVISIAQPRTVTTRWGTTLSLVEVLVGDETKSGFAVTFWLTPDQATTSQVGKLRRQDVVLMENVALHVFRGKVYGQSLRKNLTRVSLLWRSEGGGYYHNRDLARRAATKHPQREKTRLVKDWVLHFVGRDVGAVTRKRASRKSWDQPPDDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9H5</accession>
    <name>A0A2T4C9H5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable beta-glucosidase btgE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1461425</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9H5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9H5"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015699532" description="Probable beta-glucosidase btgE" evidence="13">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB78219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="305" mass="32187" checksum="07ADB54FB5DA5D5D" modified="2018-07-18" version="1">MSQHSSLFAAQLLAAQVAAAPKPKPQPHAPSGGLSGSNDHYGITYTPYEASSGNCKSASEVDADIAKLKAAGFQVLRVYSTDCNTLENVGTAAKKYGIDMIIGVFVKGDGCSYDTPDIKNQVDAISSWAQWDMVKLFVVGNEAIMNNFCSPQQLASLVSTVKEKCSGYNGPYTISETLNIWQRSDVSSAICGVVDVTGANIHPFFNSATTPENAGDFVSGQLELLGKICPGNDVINLECGWPKQGSCNGAACPGDNEQATAIKSIRDSCGSKTVFFSYDDDLWKQPGSFGCEQSWGAAAAFAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9I5</accession>
    <name>A0A2T4C9I5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1351344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9I5"/>
    <dbReference type="STRING" id="983965.A0A2T4C9I5"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="252"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="592"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB78172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="666" mass="73664" checksum="485260F8B5552E71" modified="2018-07-18" version="1">MLIRLRGPDGMIRLTVEPTTTFGDLGHQLLTHLPSTVDPKTIVLSNSPTGRDAKRLGDIVQFQIGQIGLKHGDLIFLSYQHQPDGGAPNGDVPAPVISARLNGKPVLPTEDHPIDPKPERISKPWEVVKQSALDDRLDKLDGKIPRGRGRMCRHGPKGMCDYCQPMDPFDPGYLADNGIKYLSFHSYLRKINAATNKPESGTSYIPPLVEPYFRVKRDCPSGHPAWPEGICTKCQPSAITLNPQTFRMVDHVEFSSPSIIDGFIDAWRKTGSQRLGYLYGRYAEYTKVPLGVKAVVEAIYEPPQVDEIDGITMNAWENQKEVDHIAKLCGLEPVGVIWTDLLDSGRGDGSVVCKRHLESYYLSSLEICFSSRLQAQYPKPSKWSDSGQFGSNFVTCVITGDEDGNIGISAYQMSNEAVEMVRADIVEPSADPNSMLVREEEEDDGSVSRTRYIPEVFYSKINEYGAKVQQNAKPAFPVEYLFVTLTHGFPDEAKPTFITQTGFPIENREYIGESQEHSALARALNLRSGQKPSDNGQEVSNFHILCFIHLLGVLSKDEEALLCRVATQHDLADWFQLRSTGGWQTLQVILNSTGERIPKRPREDGGGPPKTSSSVTPPPSSSNHSTAPSVVGERDEPLAKRFAAFRLNERRASTPSNPLPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9X9</accession>
    <name>A0A2T4C9X9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1329663</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9X9"/>
    <dbReference type="STRING" id="983965.A0A2T4C9X9"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="465"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="561"/>
            <end position="563"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB78344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="605" mass="68238" checksum="C7C86D846F0182C4" modified="2018-07-18" version="1">MAATRDPTTLSNYGAWRTKHTSANFNIDFDNKRLKGSVVLQLESQTDKQSTEIVLDSRFVKVSSVSVDDAAAQWELKPHSDPFGAPLHIQVPQGAAKGDVVSVAIELETTSKCTALQWLTPAQTSNKKHPYMFSQCQAINARSIFPCQDTPDVKSTISFKFTSTLPVVASGVAVGDHTATPGVEKVYEFEQKVPIPSYLFAVASGDIVAAPIGSRSKVVTGPNELKGCQWELERDMEKFLEIAESIVFPYRWGEYNVLVLPPSFPYGGMENPIYTFATPTIISGDRQNVDVIAHELAHSWSGNLVSNASWEHFWLNEGWTVYLERRIEAAVHGEPQFDFSSIIGWKALEDAVAHFGKDHEYTKLIISHDNVDPEDVYSTVAYEKGFHFLYYLDRLVGRDNFNKFIPHYFTKWAGKSLDSFEFRDTFMDFFNNLGDEEVKQKVATIDWEAKFYTPGLPPKPDFDTTLASQCYELAEKWKDASYEPSPKDVESFSSNQKIVFLEKLQQFEPLSAERAQLLGKAYDLLNTQNVELKFAYLQLALKANDASSYQTTADLLGKVGRMKFVRPLFRSLNKVDRNLALETFAKNKDFYHPICRGMVEKDLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAP6</accession>
    <name>A0A2T4CAP6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_265607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAP6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="141" mass="16029" checksum="04FC77AF48188163" modified="2018-07-18" version="1">MCRDCMSTCIDLLTASSRCRHLLRSSIIWRLLTCVTSRPKFAERPWSISQLGSCKSLADRILQARSESRWDAAGMRFFGMAHCWCSITDTNDKTKDFVVFRLARGRGYKAHLTLHRASCRGRCINSPSPSGARGRLPIFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAW5</accession>
    <name>A0A2T4CAW5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1373538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAW5"/>
    <dbReference type="STRING" id="983965.A0A2T4CAW5"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="276" mass="31083" checksum="0497A7CA75214E08" modified="2018-07-18" version="1">MAMRFLSIQRPLLAAAVAGISRPSVAVSGLIAPIGAQLANALVEGRRNASVKAQGAYKKKSKRGIPNKLGAKRTGDQFVIPGNIIYKQRGTHWWPGENCIMGRDHTIHAMATGYVKYYRDPARHPDRKYIGVVFNKEDTLPYPQHAERKRKLNKTVHALRGEAAKEEVSPSGIPFEVTRVEAGEPDRLLRLRADYSYREDNWRIGRLVKTTGLKTKAFRTRKQWFRHRRWRREREIAGQKEAARKRAESGGEGKVVKAISKKAAKKAAKKAGKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB18</accession>
    <name>A0A2T4CB18_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1390355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB18"/>
    <dbReference type="STRING" id="983965.A0A2T4CB18"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="234" mass="24454" checksum="368C627C9066A699" modified="2018-07-18" version="1">MPRAKCCSHPHQRKPAPLASPPEGICRGLQRKLQEYETKGVAATLEMQQAARDVAIENARLRLLLAHSGVTADAIEGFLQSFKGQDASEAEHYAARIATAESIAALGRPSTVATLFPEHAHIDKLAVLASASMQQSASGHDSDGTITSDDSTTGLSTGPVTPSSSSLNAPSPSDGGFEAPQTMSCDAAAHIIAQMQGCGLREPSKGSLEASNQGDYLIQNSAFLKILEAASIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB74</accession>
    <name>A0A2T4CB74_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1461835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB74"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="148" mass="16868" checksum="B34C5D5FE5B28BB2" modified="2018-07-18" version="1">MPLWLIYHPPTAYTDPSTKDALVKALTSIYTAFGLPAFYVVVHFIQVPLESTYIGGVTRSASDPPFIRLRADHIAHNFPPDDDKAIRDAGDTFSDVLAPRMRELGYDWEFHIAETDRRLWKVNGLTPPERETEGERLWIGANRPVPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBA2</accession>
    <name>A0A2T4CBA2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1399965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBA2"/>
    <dbReference type="STRING" id="983965.A0A2T4CBA2"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB78843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="319" mass="35765" checksum="3258226F53C92B9E" modified="2018-07-18" version="1">MATKGIGCLGEAMAALRISASKPATTSLSRQFTRSMATEAPLKQTANSPATAQSLLQSWNPISTVPVTIHSFPSLEPQSLEQWSVQHLYLPLRRDLLHLAVVYEGDNTRQGTASSKTRYDVHGSHRKMRPQKGTGRARQGTRQSPILRGGGKTFGPHPRDFGTRLNRKVYDKAWRTALSYRYRRGELVVCEDGMELAMPQDFDLVADRHLKDGLREAYLKKYMSGVLSTLGLGKEYGRTLFVTGDRRDRLYEAMEQVPWEGRALDLEDVDVKDLLETGKVVMERSVLREMIEQHQSDLVSRIFVNGLPKGGPPLGEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBB8</accession>
    <name>A0A2T4CBB8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1328145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBB8"/>
    <dbReference type="STRING" id="983965.A0A2T4CBB8"/>
    <dbReference type="OrthoDB" id="4899457at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="240" mass="25318" checksum="57B9078B46D07CFC" modified="2018-07-18" version="1">MKPILEIERTVQELDQLVDAKSAEVAELKLRVMLLEETDTDTAALRQQLDVAVREAQRWREKAEAAESKARIFEKFTSRIRSIHSSLAVGEGSRVSGDANELVSTQGKDAEGSYRAYRVRFSDGPVAGGSTGTEGEIVAEELDDGGELTSPSTATPWSSEQGAPYPTAPGLPALQSLDGVTSPAATAGQGSMDFSSAAMAMWVATQELLMMEDEEAASPTPGISTGSTDGSSSESIGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBX9</accession>
    <name>A0A2T4CBX9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1419468</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBX9"/>
    <dbReference type="STRING" id="983965.A0A2T4CBX9"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="281"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="491"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB79044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="683" mass="74383" checksum="F53EC3F0C9F83717" modified="2018-07-18" version="1">MLRSRQVTSRAVRTLGQARAFTSTTKPVLIQSGQRKQANASAAPQVRPVPSPAFNAETKDRSHVQPLVNPSKPDMDESFIGKTGGEIFHEMMLRQGVKHIFGYPGGAILPVFDAIYNSKHFDFILPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMQDALSDGTPLVVFCGQVPTTAIGSDAFQEADVVGISRACTKWNVMVKSVAELPRRINEAFEIATSGRPGPVLVDLPKDVTAGILRRAIPTETALPSLPSAASRAAMELSSKQLNASIKRAADLINIAKKPVIYAGQGVIQSEGGVELLKQLADKASIPVTTTLHGLGAYDELDEKSLHMLGMHGSAYANMAMQQADLIIALGSRFDDRVTLNVSKFAPAARQAAAEGRGGIIHFEIMPKNINKVIQATEAVEGDVATNLKHLIPQISEKSMADRGEWFGLINEWKKKWPLSNYQRAERAGMIKPQTVMEEISNLTANRKDKTYIATGVGQHQMWVAQHFRWRHPRSMITSGGLGTMGYGLPAAIGAKVAQPDALVIDVDGDASFNMTLTELSTAAQFNIGVKVVVLNNEEQGMVTQWQNLFYEDRYAHTHQKNPDFMKLADAMGVQHQRVTEPEKLVDALTWLINTDGPALLEVVTDKKVPVLPMVPAGSALHEFLVFEPEKDRQRRELMKERTKGVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC52</accession>
    <name>A0A2T4CC52_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1161108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC52"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="135" mass="14822" checksum="1DA496F7FB7E798C" modified="2018-07-18" version="1">MCTHNWGPGNCAEVSFERFLLITVVGIVGIVGSQGRIHSIHHEVTKSSSGPRIAIHQKLQLLTGPLARNLLCSILSFGHFRGQTPLVCQKGRVENCRFLGPPKRTRDQPPSRLISLSDKRHSSRAGQRVTCSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC78</accession>
    <name>A0A2T4CC78_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M440DRAFT_1398453</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC78"/>
    <dbReference type="STRING" id="983965.A0A2T4CC78"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="63"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PTB79181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="457" mass="49517" checksum="54F12F4656C8E9BE" modified="2018-07-18" version="1">MVQISEVKGNKRDNRTAAHTHIKGLGLKPDGYADTQAAGFVGQVPARESCGVVVDLIRAHKMAGRGVLLAGGPGTGKTALALAISQELGTKIPFCPIVGSEIYSSEVKKTEVLMENFRRAIGLKVRETKEVYEGEVTELTPEEAENPLGGYGKTISTLLIGLKSAKGQKKLRLDPSIYEAIQKERVTVGDVIYIEANTGACKRVGRSDAYATEFDLEAEEYVPIPKGDVHKKKEIVQDVTLHDLDVANARPQGGQDIMSMMGQLLKPKMTEITDKLRAEINKVVGKYIDQGVAELVPGVLFIDEAHMLDIECFTYLNRALESHLAPIVVLASNRGMSTIRGTDDVVAAHGIPPDFLARMLIIPTSPYSADEIKKIVKLRATTEGVAITDAAIDKISEHGVRVSLRYCLQLLTPSSILAKANGRTQIDVQDVAECEDLFLDARRSASLLASEAGRGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCB0</accession>
    <name>A0A2T4CCB0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1370942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCB0"/>
    <dbReference type="STRING" id="983965.A0A2T4CCB0"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="175" mass="20129" checksum="5769ED1CF243DF67" modified="2018-07-18" version="1">MLIPKADRKKIHEYLFREGVLVAQKDFNLPKHPDIDTKNLFVIKAAQSLNSRGYVKTQFSWQYYYYTLTPEGLDYLREWLHLPAEIVPATHIKQQRSHAPPRGMLGEGERERRPFGGRGRGGDRGDREGGYRRRDAGEGKEGGAPGEFAPQLSSEIICIRVNVCHQRDNFLLLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCC1</accession>
    <name>A0A2T4CCC1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UFD1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1349753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCC1"/>
    <dbReference type="STRING" id="983965.A0A2T4CCC1"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="128"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB79219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="372" mass="40606" checksum="6F35DBA5D7F91CD1" modified="2018-07-18" version="1">MAGYGAFGAGGDLYGMARVGRRPIIQRFDEYYRCYPLIMAPGSERPELNFGSKIILPPSALDKVSKLHVQWPLLMELINGEKGKHSHAGVLEFIAEEGRAYIPQWMMVTLGLDVGDMIQIRTTSLELARMVKLQPQSVNFLDISDPKAVLEKAFRNFATLTKGDIFNFEYNDEVYEVAVLDVKPETEKMGVSMIETDVSVEFAAPVGYVEPEKKSGTSTPRSAMGGVPAGGVLHSQGTMAQAINYSAIAPSVTSVPTNFIGEGQRVAKKGSKTATPKPATPVPVDTTPVLKRRDGAPAPLRLPPNKLFFGYEFKPLKTDADKEKEKETSSKPHFAGQGQSLRATTKRKGDADDKSKAPDKKSTNGSRPDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCJ5</accession>
    <name>A0A2T4CCJ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1326599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">ATCC 18648</strain>
        </source>
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="20"/>
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    </feature>
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        <location>
            <begin position="21"/>
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            <begin position="89"/>
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            <begin position="122"/>
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        </location>
    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="PTB79367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="133" mass="15159" checksum="946B69B51E356977" modified="2018-07-18" version="1">MWSDYMLLLLLYHSWHVALRLILKECHWLSTLQSRSTECFESKALTMTWMDSGLERVDLVLPSCRNVRLRRETPKTRPRGVVQSQNAKAKLHMGKKRPPKLPKSTMLSGGPRSTREGVSGGTPYSSASYRRAA</sequence>
</entry>
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    <accession>A0A2T4CD82</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">ATCC 18648</strain>
        </source>
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        </location>
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            <begin position="115"/>
            <end position="126"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="PTB79494.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="191" mass="21772" checksum="BD90E08F92021331" modified="2018-07-18" version="1">MTTYCVFLPFPLFRQYCRFTHDALELASMDQRASTPWPHLAPRCHVVIHQPVPSPYNSPTHRQIAADTTDTLELESQFLPLDSSLSFVGRISLIPAFRVRGNETQTKRKGLDMRHRSRAWRKGRTKGARDESRRKSQSATMPQGDGCHQICRHVRLARVTGRNKGRIGDLVHPLFPSIPLTGAHGRKSRRI</sequence>
</entry>
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    <accession>A0A2T4CDR3</accession>
    <name>A0A2T4CDR3_TRILO</name>
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        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">M440DRAFT_1420015</name>
    </gene>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
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        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
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        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1234"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1569" mass="174857" checksum="4D60C077FF70A8E5" modified="2018-07-18" version="1">MTDFLYAPKAQTFQDEHMSPQPGDDVSSPDSLRPSGIASVFRGLTGSKSSIKSPPPLSSSAAALPRTDFIHATPISSRGLSANHMDAFEQLKNGSPAERIAAANTLKFAITEYPLNPVLDIWYAAKDLIEPSKPTAMRQAGWELLTECVKHSSSTDLERKEYFQTIAAPANPEDFHLQLAALVDLTHRGRILAGFDYELLPLLTRWLQEAYNAARAARKASQATRGQRTSKNKAAATGEDQNFAQLFAFIMDVIKFNFNTADQNSITGLIDRLLGICMSTSVEEDLRSCISAIDAIVTFGSVPTSRLKSTIQVLSSIFCLVHSLHKESWHTLANLCKSHNGQAAVRILLDVLRNPSLDEVSNKDMGRDIRGALAVLQKLLSKTTEKGYPTVPYALLVDGLANTLKISSSPRIYHAILQLINSLFNDGNGQLHRLVLDEDWSVPLETAAECSRRIQEIPDSTTGARPRDDSMDDSIRYELQLLIARLDQLVTQKSGDFVPRQTVIKFFTDVHRLLPDHTARTVLDYFQEFRCCSPSDLRWEENLTLVLDGFFRNRSRSSETRLRALQTMMDAYEIVDLVGDGDEQDFIPRLAKSILQDVTEEVDVLVLDAIISFMTSVVVACDIDLFDFVINALRVIVVSDRLKSPIASPTSPLVLSIPPAGGVESTELAPTEQSPSNVVTRGYVRMFMRLMNFHNDKSVKLFNVLVSIAKLDHCEVDARLTAMKLLFRLRADWADRVFITNNLEAMSTATTLLRTEGSLAKKQAEEVANTARLSRVDVGLQSRSSTRGASIGQGRAGQRQGYMWKYPDPNALPEAIPSMISPILRSHLHKEDAAEGEEQTAEVAHYQPCALDISAWLDTVLSMLQGCDWEIYSFVLVHLPSQLSNHAIFRDAIPQIQELRRVICEQIRLNSFQEPPNALGLRRADIAICLYHSLTMILSYHEHFQKVEEDEIVKISLIQMLNQMAAIITQPFVSVHILEFLACLSRLHNVYVNFREDEFRIVFAICFRYLEYAKDKRQVQRSALSSELPTPIASSVQSPSELNQPPTDDLPQYVHALAYHVILFWFLALKLPDRANHVSWIAKKLFADADGLHQGPDDHAVTSIDFMQRVTYADVDESAEDPYFTEDRFGDIAVKRWLVGNSIVTVKQATVSGWAQIIKRQPSGTSAYTVRESYRPPPPHQVENHVDITREGQPTSNLILPSHLLVQLMSPIPQTHDSARPIPLPDDEATGRAIRVFDRLSSLDGHKVGVIYIGEGQTEEVEILANVSGSSDYIEFLNNLGTLTKLKGATFNTQGLDREHDTDGQYTFCWRDRVTEIVFHVTTQMPTNLERDPQCIAKKRHIGNDFVNIVFNDSGLPFKFDTFPSQFNCVNIVITPASPASFLATREANPEQAHKKKFYTVQVMSKPGFPAISPASDTKMVSLKALPAFIRLLALNASVFAHVWHNREGGEHISSWSGRLREIKRLRERHGPKAGSVSLASPPTLITTGTPVQSPPLHPFQDLAQPGVSSVRDSFNSLRRTSVATFFTNTSEQTSHRSSILSTAPTNDTEVGMNGLDSLVEAVDFSKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDT1</accession>
    <name>A0A2T4CDT1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_245896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDT1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16598" checksum="9F08E33AAF35132E" modified="2018-07-18" version="1">MSEPHELCEGSSTDRLSASVFKVVAEFMFEADLIQLRVSKLRSSMLEGGSEAVSNDPCSQCVGCDCGTDAVSLRALKSRYGPARLSGSHSRRAPGAASWPAAHMCPRSIDEIWDDKNLEKASRCICVCFSLLRHTDGNGYNSPRFARVVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CEB5</accession>
    <name>A0A2T4CEB5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_174095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB79893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CEB5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="185" mass="20534" checksum="0B618682DB505A9B" modified="2018-07-18" version="1">MLGPESGDAPNSSSITHEREREPPLGFAIRTTSAPYMSVYQQPRRPDIGDCAWLIDTQPLSCARPRGNWLGKESDAHESTRAYTGSAAILHLCVPLVLVITCATPKESSNYTQKNTERGRRHGMDFLCLGRGRIGRNLDKRARRIEAPSLAAAMWARPCLSELTTYLSMTCTKYGLSTHGLRFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF49</accession>
    <name>A0A2T4CF49_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_47158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF49"/>
    <dbReference type="STRING" id="983965.A0A2T4CF49"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB80174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="515" mass="56891" checksum="A7D884237B180605" modified="2018-07-18" version="1">MKFSPLELPPGTAPFFHDAANRTWMPLYSHACSFGPDIFVDKMMNLIKNPNLNSSWLFRADILYDEAKATDTSSSGIRPVAVEIHGMTLKRTLVRRLIPRNERRDKPLEQTCLFYTSTTPLNPAADSDEAGSGLVHEEAVSGSASPAPLSTLVIYMPHSPSADALPFYHPKVQGIAHLHQWDPSGKGTISVHFLPYPEHPVADDARLQRTAYHLLEIIDKHGHGAAEGYVKRVHHDVVIPQDRFQNRYALLKSKYARRLVDSWAEKTDPTKHVFEDLGIAAFLIELWSDMYPEGAAGFPGFVDIGCGNGLLVYLLNQEGYAGWGFDARERKSWAQYRTGGQPSPWGSSLEERLLLPAMHSAGSDRSEGSISSGVVHDGKFAPGTFIVSNHADELTPWTPILAALSRCPFIMIPCCSHSLAGDKFRAPPPRDKAKARSTYASLVDWVSGIAEDCGWKVETEMLRIPSTRNTCLLGRTRTREVREADVEALVSSKYGGTGGYYENVAKLIKSGPRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CF64</accession>
    <name>A0A2T4CF64_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1325084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CF64"/>
    <dbReference type="STRING" id="983965.A0A2T4CF64"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="557" mass="62446" checksum="C50CB73AD92F2C16" modified="2018-07-18" version="1">MANHPEEDDEEDDVYSDDFDPREAALLEGLTRRTNRAQQIRLRQTPGHVQGPAGDVPGPDGDQDHDYACYYDYRYDIDSDDASSTGRDRKRSHTPYTLDSASRTSTVYQVKCTWDGPGEPPLSFRLDDFIAYMKECHLTHAPSAALPLSLLPQDDYTASEMLKYYSKRPEELQTKPVPDLNPVNPKLIDLAYSNPLVLQLIMAQKANHRQVSSAMLPTGERAESFYAAAIADFGPMIDSYLAGNEQDMLPLTLASLVISLTERARLDKRGQAHNYPTAAKGILKTLLTLPHGEMCKQVPPVLLEYYMHAACFACVAADVTKAESVPFMSEALRDTVDDMVEAKYIGKLCGSWLQIMVVVQSIFELGMRMRPFADDASDDPTGGPSTGYMPNHFVTFGQIQERLFRFKPNKDPLCENVEAATFFRDATMLYLWSLLEWPHASTPPGSYSNYMESSYKDALLQLSRISEIASINKALCWPLLIVGCFAKTAKVKGIITSRLLSIAGRFKVGNALETLFLLQHVWSLPFARRNPWMVHKSIRHTRCCGCVCSDCMSRLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFA1</accession>
    <name>A0A2T4CFA1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1397548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFA1"/>
    <dbReference type="OrthoDB" id="5305593at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="106" mass="11765" checksum="2C0759195D277DEB" modified="2018-07-18" version="1">MALYADDAKLTAHLFGLVNVDKAHIRAFYADLFAANDGVEFVTRCISGTPDLVVWECDVRCRARRASAVLGIARGEAVVLRGVSLLSWREGLIAEQKDYFHVLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFC2</accession>
    <name>A0A2T4CFC2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_188231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFC2"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="172" mass="19558" checksum="4112E51267A1F629" modified="2018-07-18" version="1">MPPCGELSNAISTKNRGKRLSRFSLADTACDETSALRDNGSLVEVFAFVCAIMSSAEDNGKGHSTAEPTTINMRRTRTFWVRREGKKRRVNNAARPPDTQGISNERDNLPFLEDGALRVHRSYTKYFVRLPASYNTWYTYTFMYYLHCVHYIVLAIFPVHSQRLLVATSIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFP0</accession>
    <name>A0A2T4CFP0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1397738</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFP0"/>
    <dbReference type="STRING" id="983965.A0A2T4CFP0"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="174"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="414"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="687"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB80385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="753" mass="82710" checksum="7783BC48ACBE4693" modified="2018-07-18" version="1">MVDDGMVMNFELGGGPLKPQVKFTGGNWRDRKRAQKSAKLGSRPTAERGEHDEDQRSAKRQRVDGHGPGRRTEGDSERGTDLPRKKTAEHGHAAGQKRGPGGGSRQVVSRLFSFNPEQKTTFEDETEWKEPEPTNAPLQTVANFGSLTISSRLVDALAKMNLERPTAIQQKVIPHMLSSSSDAFVQAETGSGKTFAYLLPILHRVLQLSGRGDQQIHRDSGIFAIIVAPTRELAKQTHTVLEQLIRPFPWLVSTAITGGESKKAEKARLRKGVNFLVATPGRLADHIDNTKALNLGTVRWLILDEGDRLMDLGFEEDLKKAINALKQVQLSKTLVSGVSLDPLPDRRVTVLCSATMKMNVQKLGEMSLADATFLAAEKGDETAAEQKDDQAVHRAPAQLHQSHIIVPAKLRLVTLIAYLKSVFSRRGQTMKAIIFMSCADTVDFHYELLKIPDSGDVPPPASKDAENTSKTVAKAAYITSLASPEVVLHRMHGSLSQPVRTATLRSFSACKSPSLLITTDVSSRGLDIPSVDLVIEYDPAFSFADHIHRIGRTARAGRSGDAVIFLLPGTEEGYIELLKASGSPTPLSYESVLQKGLMSKLEFPVETTAKPEEGQNYHEKAETLQLHLEQRLLIDSKRLEMARNGFKSHIRAYATHTREERVHFDITQLHLGHVAKAYGLRDPPGGIGAGIDRKAQKGNKDSGKRTVKGAKATKKDDSDDEDSDKQEPTKPARAMLMRKSRMLMSGANEFNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFQ8</accession>
    <name>A0A2T4CFQ8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1397755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFQ8"/>
    <dbReference type="STRING" id="983965.A0A2T4CFQ8"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="14"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB80401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="648" mass="71301" checksum="877B71FB3BE848A2" modified="2018-07-18" version="1">MIRNIPPSARAPIVRIANGTFYRHHPNAHSAHANPALFKNLSFELPSSTPQPHNWCVVGPSLSGKTTFLHVLRGRLICEPPTARSYPYLSSDAVPARLRTPSKAIQYVGFDAEQGPGGLGGAVTTSAYLSARYESRREITDFSLRDFLLGNTELNPAKAPGQESEEEGGISDELLKRIVKDLRLEHLLDLPVTFLSNGQGRRARIARALLTRPEVLLLDEPFMGLDPPTVSGLSPLLESLAEKANPRLVLSARPQDPLPEWITHLVYLRMDCQVESMGPKEVVLDGLKKYVHGVRVGGIAEDEKLPVHTLADIGRVLSKDVLTANSASSSSSSSHLQKPINPNAEPLVEMDGCQVRYGDKIALGNWSQKTPEGDKPGLIWTVRRGERWGVFGPNGSGKTTIVSLLGSDHPQAYSLPLKLFGRSRLPEPGSGQLPLTFWDIQSRIGHSSPEVHQHMPRSHTIRQVIENAWAETFGAKPKLDPEASAKVEAALRWFEPELKPNSAAGSEGLKWADEYMFGEVSFSAQRVALFIRSMIKGPDIVVLDESFSGMDDAVRDKCTLFLTEGEAKTYVGEEIVESQQSKEGTVKVKGLSDQQALICIAHIKEEVPDCVREWICLPEANTGLPARFGRLDGALREEEGRWNEIWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CFU7</accession>
    <name>A0A2T4CFU7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1125295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CFU7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="130" mass="14951" checksum="BF8E370A2F2CCF97" modified="2018-07-18" version="1">MTRSIWRWQPHTTRCSVSNEYRARGLRNSCRLIFVTAAVFKNSSCSYLYPFPVLAIEGLLRIWYPCSVSVSGCLLLWQRKARISSSNYGAHSQVGTTRPGTRLMHARLTLPPETLMARYLCMLFLMFLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CG32</accession>
    <name>A0A2T4CG32_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1324665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CG32"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 SIN3 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB80503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="173" mass="19090" checksum="5C9A345AF682BE1D" modified="2018-07-18" version="1">MAPTKNSRKDHDDHKGDAPAEKKNGHGSAKMRRGASQQTHAASRELPPAPTSAPTQAPTEPLLPSLPWSSFERRSLHAYVREHELTTPASYASSFHNWVLSRPGSLGLHSPTMVRKQQIKRQSKDQLALAVRKHFNGLGIQENDVIVDFIYKVRNHQGAKAKAPTKHALAATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGI9</accession>
    <name>A0A2T4CGI9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1419214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGI9"/>
    <dbReference type="OrthoDB" id="4880172at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB80666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="199" mass="22962" checksum="7B1D2FC9226677F2" modified="2018-07-18" version="1">MDEPDIVKTTAHTLTRDDVMDEIQPILHRLKNDEWTTELSAAIAATLTPQKLKVMSPQAKAYFAGWIYEQEDKKYVQWLKEASDDLLSMTWNETQRIPGAKIWSQRHPVASALDKLEKDSDKYSPEQKEFVQARVMEIKECLQGEKERETRQVEKFTAATLKAIEKTEAAIIGRLETRLDEMRPTEKVTRKVAGMTFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGK0</accession>
    <name>A0A2T4CGK0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1314186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGK0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB80673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="194" mass="22031" checksum="C2B21B022A20A700" modified="2018-07-18" version="1" fragment="single">GGGGDQHGSSEDSTSDYAETVDFSEFTSIDTAQMVHRYKNGRRYQGWFDERYGLPNDDTEQAREHLKHRVYSDYLLNGEYFKAPIGDNPQKIVDLGTGAGFWPIDVAERFPSARVIGTDISAIQPPWSPPNAEFRVEDLDDADRPWTRIYSGADLIHTRSVIQTVRHPELFLQRAYEALKPGGWIECHDLFIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CGW9</accession>
    <name>A0A2T4CGW9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1388985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679127">
        <property type="protein sequence ID" value="PTB80778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CGW9"/>
    <dbReference type="STRING" id="983965.A0A2T4CGW9"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB80778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="692" mass="77240" checksum="80A42D987A256EF1" modified="2018-07-18" version="1">MPLASAQLGSLRLAASGACRQRLSLSSRTAITSTRCAQLRAFSKLYSRTNKRSTPAANPTERLQSRPRPLSLVLSRALSGKPLPQPRSWVLNFLYRAAAWLGISCVVLGTGVLGFFLYDASTYKEHGTQSDIDVSQLALQPRRGGPKNLPIAEVFIDDTEEHPGKSKPRLVVLGGGWGGVALLKDLNPDDYHVTVISPTNYFLFTPMLPSATVGTLELRSLVEPIRRILSRVHGHFIRAKAEDVEFSYKLVEVSQLDHMGREVRFYVPYDKLVIAVGSATNPHGVKGLENAFFLKDINDARMIRNKVIQNLEIACLPTTTDEERKRLLSFVVSGGGPTGVEFAAELFDLLNEDLTRHFPRLLRNEISVHIIQSRSHILNTYDETVSKYAEERFARDQVEVLTNSRVKEVQPDKIIFSQKQEDGTVVTKELPIGFCLWSTGVSPTALSQKLAKKLGASQTNRHALETDTHLRLNGAPLGDVYAIGDCATVQNNVADSIVSFLRKLAWSRGIEPESLQLHFSDWRNVAADVKKRFPQAINHLKRLDKLFYEFDKDQSGTLDFGELRELLNQIDSKLTSLPATAQRAHQQGQYLAHKFNKLAKISDAMLANDIRDGDLDAAVYKAFEYRHLGSLAYIGNSAVFDLGEGWSMAGGLWAVYAWRSVYFAQSVSFRTRSLMAMDWMKRGLFGRDLVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CH48</accession>
    <name>A0A2T4CH48_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1434823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB80876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CH48"/>
    <dbReference type="STRING" id="983965.A0A2T4CH48"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="205"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB80876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="553" mass="60588" checksum="26246E8B35C49091" modified="2018-07-18" version="1">MVGGGAEMHVACMPLHSSSHLNSAEAAAAAQPATHEAEYAPSLLSEIAARRAKAGKLVAGIAAASDSDMFKGPQTGKPKAKRWDDHLSAESKLREPCSLKQAAKHLKQPGLISLGGGLPSSELFPLDELNMKVAMPPDFSEKATASHGQHVTIGKYDVRDRDGTYDLSIALNYGQATGSAQMIRFLTEHTEIVCKPPYADWRVCQTIGSTGALEQALRMFLDKERGDSVLTEDFSFSTALETISPLGVKAFGVPVDDQGLIPEAMDELLSNWDAKARGSRKPHLLYTVPSGQNPTGATQGLERRQAIYRVAQKHDLFILEDEPYYFLQMQPYTGRGQPDAPAPSNVEDFVSSLIPTYVSMDVDGRVMRMDSLSKVLVPGSRLGWIVASEQIVERYQRHAEVASQGPSGFSQVIVHKLLDETWGHEGYLQWLMNLRLEYTKKRDALLAACEDNLPRDLVSWTPPAAGMFLWFTVDHTKHPSAGTRSLEEIEQEIFDSCIKSGVLVARGSWFQTEKDAPLTSLHFRATFAAASPENMNAAIARFGKAVEDSFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CHJ4</accession>
    <name>A0A2T4CHJ4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1345527</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CHJ4"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB81045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1410" mass="162798" checksum="822A5CC1B37E6FD6" modified="2018-07-18" version="1">MSSAMRDLISGEAELDDEEDDESFDEETGQERRRKPAAHIDDSSEEEEDDDDEEEARKIREGFIVDEDEEEEEAESDVESRPVKRKREHRNREEEELLDEEDLELIGEQFGEQPKPQAPSKFKRLKRGHRDEDDTGHEKRGLEEIFADEEDDAAEQRSYGRPGFRSQVDEFDDFIEEDYPEDEDERIRQQEDAEVARPRDRGVGGVVDTTGLDKDALDDMEAIFGNGEDYDWALQMEEEEEDREREEQGIELKDVFEPSQLKEKLLTDEDNEIRFTDEPERFQLDRKPFKNLQLTPDQFKEESRWITNQLWPKKGLAQELQAPFGKAVGKVLEFFIVDEVEVPFVFQHRKDYLLHSKKIRKSTRDDPDGPDYTIQSDKLLNQDDLWRILELDIKFRSFVEKRNALEKSYDNLKSMDVKDETVEEMIPEATTMEEIQDLQDYLQFQYANKLRDLASLSGNASQTKRPGSKSTLLDRVRNGKAYYFVKAYGITADQLAKNALRQGRKVAPDDHEQYPMDLADSLTDENFSTGDQVINAARQMYAEELFASPRMRKYLRASFYQAAEISCRRTEKGLRKIDETHPYYEIKYIQNQAIADLVHQPEVFLKMMRAEEEGLVEIKVEMPSRYDFRRQLYQEFESENFSDRAEQWREERRKVLDLAYPKLEKIVAKNIKEVIRTFCQDEVLKMCRQEFYRKLDQAPYKPKGMILGTTPRVLVLSNGGGDPTRDPVCWAWVEEEGRVLEQGKFGNLGRDEAQRENFVELVRRRRPDVIGVSGWSADTHKLVRDLEGLVSEKGLMGAEFEDPETNDYRTELLEVVVVEDEVARLYKDSPRAIAEHPSLNSVTRYCIALARYLQNPMKEYAALGKDVASLSFHPCQNLLPRDKLMKYLESAMVDTVNMVGVNINEAMTDTYTANLLPYVAGLGPRKATSVIKTINANGGVVNTRDELVGDPDSGKLPVVGPRVWNNCASFLYIEYDATNPSSDPLDNTRVHPEDYELGRKMAADALELDEEDVKAETDENGPGAIVRKLFKQDEQERVNELVLDEYADQLQRNFSQRKRATLEAISAELQAPYEELRRSFALLTPSDIFTMFTGETKSTLCEGMIVPVNVRMVRDDFAIVKLDCGIEGRIEGHEVSNRASVKDVLSTGQTVQAKILEMNYKDFMAKLSIREEALRIPYKAPINFGRDGWDYALEAADKEELREKDKTTGRTQRVVKHPNFKPFNSIQAEEYLGSQPPGEVIIRPSSKGNDHLAITWKVADGVYQHIDVLEMQKETEFSVGKLLRIGGKYTYSDLDELIVDHVKAMARKVEEMMRHDKYQNRSRSETEKWLITYVDANPNRSAYAFCIDTKHPGYFWLCFKASKTARVIGLPVRTIPQGFELRGYQYPDMRALCNGFKLRFQNEFSKMGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIA4</accession>
    <name>A0A2T4CIA4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_80155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIA4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015413203" evidence="2">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB81252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="113" mass="12206" checksum="480AAD3DFA9AE076" modified="2018-07-18" version="1">MSSTPSPSSSSSLHLPSHRVTNQSQRWRSWTWTLILLWALFLSGDGNRGLDCSDPCMAGKLLRCLPRRLTCSRRCLGSAFDFAVASPAASVGPNDSSARVALPCPGLPLGRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CIH0</accession>
    <name>A0A2T4CIH0_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1014189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CIH0"/>
    <dbReference type="STRING" id="983965.A0A2T4CIH0"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000071">
        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="165"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="291"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="532"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="712" mass="80265" checksum="095F696E55F0C85B" modified="2018-07-18" version="1">MDAAGLHHGRDSAGVLRDEVQQGLREQQPFIRQPRSSSRFRPSRRQSRSRPLWELGLFFFIVVISVLALSAVPFSLQSLSKGSSDGLDEHHSPEGPHEEDESGHSDPDAGDEDDGSPAPAIVHYYEEELPSVPQLRDVSQYILAPSWDFDAAPTTREYHWTIVDGRLNPDGIYRPMILINNQFPGPLVECNEGDTLRVIVENKALNATSIHFHGLFQNGTNSMDGAVGITQCPIAPNSTFTYEFQVQNQSGTYWYHAHHSAQASDGLLGPVVIHSKEERTVLQKLEYASDRIVMVQDHYHNLTSELLMDYLKPDMGNDEPVPDNGLINGRGVRDCADFPGWDCDTTNLSAPTLDLAAGQRHRLRIINVGAFAEFQIQFDEHPFYVTEVDGTDVFPEPFHRLNILPAQRYSVIVETNVTTADAFWMRARMVTHCFTTKNPRLKPEMRAVMRYNPSEDTPSDKEVKDPASKDWPDAIEVICRDLNVSALHPVVPMTPPPADKYMRFDASFMIGDWRLARGFFNDSTWHHNATRPSLHRFLDAHSNLTTLSSPIAVNSLAFDPKRELVIQTKGIRTIDLAINNFDDGSHPFHLHGHKFFVLHQARSGYPPSEADFPAFAKELELEENPLRRDTVTVEGYSWAVIRVVLDNPGMWAFHCHNMWHAEAGMVMQLLVRSDVVRGWKVSDQEKAMCGLEGVTTGMRPDDGIWFGNFGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ70</accession>
    <name>A0A2T4CJ70_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1321593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ70"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ70"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="429"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="796"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB81562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="914" mass="103963" checksum="D16BE36B9A8C876F" modified="2018-07-18" version="1">MASDTSDDDRPLARPNGRRKFSSASTPVSSSKISRAEDAALDKSVPAKGSGMAGLSIRNGPVENGEMDLDSPATNGAKRKSRGSLTKSYKEESESDGEPLAKRQRSQQDSDSDDEPLVKARSQKLPPSYKETALPESSDDEQPLGVKLAKKKADIEKKADKEAKAIRAKEAKAKPTPKKKVKDESDDDMPIAAKKRQTNGTASKRKSTGVKKYESDSDAPISKKSRSISAPAKGKKAAPAKDTKKAKSKEPSEEADEEEFEWWNAPKKEDDSIKWTTLEHNGVLFAPDYEPLPKHVKMYYDGQPVTLAPEAEEVATFWVAMMTPASSHHLENPTFRKNFFADFSEYIKKSGGAKDAKGNKVDIKSLDKCDFSKIHEYWTAKLEAKKNMTKEEKAALKAEKDKLEAPYLYCMWDGRKQKVGNFRVEPPSLFRGRGEHPKTGKVKARVMPEQITINIGKEAKVPTPPAGHKWKAVQHDQKATWLAMWQENINGAYKYVMLGAASDVKGQSDFKKFEKARELKKHIDKIRRDYTKDLKSEVMADRQRATAMYLIDKLALRAGNEKDTENEADTVGCCSLKYEHISLQPPDQVTFDFLGKDSIRYNETARVDPQVFKNLKLFKKAPKTDGDDLFDRLNTSQLNKHLNSYMPGLTAKVFRTYNASYTMSELLKELGKDPRSRGTIAERVKLYNDCNRKVAILCNHKRTVGASHEQQMQKLGERIKGLRYQKWRTKKMILDLDPTQKKKKGAAWFEKDEDLDDEWIKEHQQFLIEEQRTKITKKFEKDNEKLKANKERPLPEKELKERLQAVKELEAKFKKENKTNKVEAEGRGVTVEKLLANIDKIDERIRILETQAEDRDGNKEVALSTSKINYIDPRLTVVFSKKFDVPIEKFFSKTLRDKFRWAIKSVEDADDWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJ75</accession>
    <name>A0A2T4CJ75_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1020408</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJ75"/>
    <dbReference type="STRING" id="983965.A0A2T4CJ75"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB81629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="469" mass="51586" checksum="095BFAFB4BFB62EC" modified="2018-07-18" version="1">MSNIHVWGSLPDAGLFNFPPANPPAPIPPAHVPTSILRPFNIPDNLYVSALDARVPLTIAVAYAITAKLLNKYNKARKNKPWGISKTRPFFCFVVLHNIFLAVYSAWTFWGMVGVMRRSFVSPFGPGGVAATADAFCRPQGPRGLGNSVYFNETTGSWDTASQSTAELLLANNGMPSTTEPGRMWNEGLNYYGWIFHLSKFYEVLDTFIILAKGKYSSTLQTYHHAGAMMCMWAGMRYMAVPIWIFCLFNSFIHSLMYTYYTLTAFSIRIPTFMKRMLTSMQITQFIIGASCAMVHSFITYVYPVTVTQVVTEESPATQSAPIDYIIPTAVSALDSLKQLIFGAGAAAGEAAAAAPSLSKTTTVTRTYDLVQPCILTTSETFAIWINVVYLAPLTYLFVSFFIASYVKRSNAAQKLKGQAARGMSDEVTLAEKAGWEAARNVEREVYGGEQNEEGAGNGNSGSRSKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJE2</accession>
    <name>A0A2T4CJE2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M440DRAFT_1367966</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJE2"/>
    <dbReference type="STRING" id="983965.A0A2T4CJE2"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="57"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PTB81680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="401" mass="44253" checksum="B500019C24189B38" modified="2018-07-18" version="1">MVPRSQSWFCPCSCLTGSSDSEPEHQQQQQSSTNRPPPNSQNNGHEMVRPPNGGRGYMNGVYYPSWLVYKGKTPATLDIDNITHVFYAFIGVNEDGSLRWIDEHADVVKDVDGEKGALAALAQLRRNHPRLKTIVSIGGGTASKEFPALAASSAARQTFARQARDFCDRHGLDGIDIDWEHPKNAEQGRDYVQLLRECRRALPEPEYLITTALPVGQYILKHIDLDAVSGIVDYINLMAYDFTGSWTKVCGNHAQLRSPGTRLQSTHPELQACATDGVEYVLSRGFPSRKLVLGIPAYARYFPRAQGPGCSTERAGEMDYCDIPDEWVREAVVDEGAVAAWYVDANGDKGYLTFDVPRTVQMKARFVMQRGLGGLFYWTGTGDKGDGLSLVAAGRRGLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJW6</accession>
    <name>A0A2T4CJW6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1025047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJW6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB81834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="204" mass="23237" checksum="B23DF4CD6A5DFA70" modified="2018-07-18" version="1">MTRPSGREHRVAQSHRPAVTPGNYLHVSKGQPWSYSAESNPLHHQHPCPSVDLPREATPLSHRRFEGNTKLSHHTWTLQRGFCSAACDKSCFGKEGRRREFEKPARATRVDFAVSPDLNSHNTTTTARRFTSASGRWIDRPRLSNELPSRAKIAVLGRHSVCSLRGSIDDDMQRVGEATLFECCPPLFSRLYPYDMGRLWMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CJZ3</accession>
    <name>A0A2T4CJZ3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_16127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CJZ3"/>
    <dbReference type="STRING" id="983965.A0A2T4CJZ3"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="686"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB81828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119713" checksum="3CDD17F9530E3FE0" modified="2018-07-18" version="1">MASSTPPKPKTLAQIRSAESDSSRGPSPQPTHVSVPPVPLALRNGHRVLRSATVGYVAPQFEGKTEQIKAVKSIIQQGGWLPENLIDEQIEWFYEKLGIDDVYFHIETPEVIANQITSLYAAKVAAHSREDKHEEIRLDMEAHDHAIYIDTSEPGKAHVSGPRYESRLESKYLDHQGKSKYRVETFRSPAAIGASPNSKATVRCYFVYQCHFKQSPESTDPKETRIEVISDVGFWQKATANTKQVYQEIIEIAVNRAGPVIEVFDIEGSAEKRLVVAFRSRTARGIFSTLSDLYHYYGVTSSRKYVEQFSNGITVMSAYLRPAPNLDGYFPSIETSIHQITKEISLLYCLPQNKFHHLFATGELSLQESVYAHSAWVFVQHFLNRLGPEYASLLEILDPKQNAHAALLSKLKRRLRTETFTPDYILEIIQSYPELVRLLYASFASVHLGVQDSNVLLATPAVEVLSDEKLRDKISKTVANEHDEMVMTAFRVFNNAILKTNYFTPTKVALSFRLDPSFLPEAEYPKPLYGMFLVIGAESRGFHLRFRDISRGGIRIVKSRSKEAYGINARNLFDENYGLASTQQRKNKDIPEGGSKGVILLDPKQQDKATEAFEKYIDSILDLLLPAETPGIKNPIVDLYGKQEILFMGPDENTADLVDWATEHAKARGAPWWKSFFTGKSPKLGGIPHDKYGMTTLSVREYVKGIYRKLDLDPSQVRKMQTGGPDGDLGSNEILLSNEKYTAVVDGSGVLADPNGLDKDELIRLARKRVMISEYDLSKLSKDGYRVLCDENNVTLPSGEVVNNGTSFRNTYHLRETNTTDCFVPCGGRPESIDLISVNRLIKEGKSIIPYIVEGANLFITQDAKLRLESAGAILYKDASANKGGVTSSSLEVLASLSFDTEGFIENMCVDPKTGKAPQFYDDYVREVQSKIQENARLEFEAIWREHEQTGIARSILSDKLSGAITDLDEKLQHSDLWENETIRKGVLREALPKMLLNKIGLDTIISRVPENYLRAIFGSYLASRFVYEFGSEPSQFAFFDFMSKKLADISGQANGAEQVRRMSISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CK16</accession>
    <name>A0A2T4CK16_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="13">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1368415</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="13"/>
    <dbReference type="EMBL" id="KZ679126">
        <property type="protein sequence ID" value="PTB81917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CK16"/>
    <dbReference type="STRING" id="983965.A0A2T4CK16"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="WSC" evidence="14">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB81917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="860" mass="91505" checksum="6574E08EF1624BD7" modified="2018-07-18" version="1">MALFHLAQARTCLPPYQAQTTYQGCYHDPNSPRDLAGPMLTVGNLNSPQYCANICGAAGYQYSGVEFTIQCFCGHRIESTSVKADESQCSSPCPADSSKVCGGGNMINIYSISNPSPNPPLTPSFPDCTRDPLCSNDVCDTTKSIAERAAAIVKPMTLDEKVANVGSSASGSARLGLPAYQWQNEALHGVAGSTGVQFQSPLGANFSAATSFPMPILLSAAFDDALVKSVATAISTEARAFANYGFAGLDFWTPNINPFRDPRWGRGMETPGEDVFRIQGYVLALIDGLQGGIDPDFYRTISTCKHFAAYDIENGRTANNLSPTQQDMADYYLPMFETCVRDAKVGSIMCAYNAVDGVPACADSYLLQDVLRDTYGFTEDFNYVVSDCDAVENVYDPHHYAANLTQAAAMSINAGTDLDCGSSYNVLNASVQAGLTTEATLEKSLVRLYSALIKVGYFDQPAEYSSLGWGNVNTTQSQALAHDAATEGMTLLKNDGTLPLSRSLSNVAIIGPWANVTTQMQGNYAGTAPLLVNPLSVFQQKWRNVKYAQGTAINSQDTSGFNAALSAASSSDVIVYLGGIDISVENEGFDRSSITWPGNQLNLISQLANLGKPLVIVQFGGGQIDDSALLSNSKVNSILWAGYPGQDGGNAIFDVLTGANPPAGRLPVTQYPADYINNNNIQDMNLRPSNGIPGRTYAWYTGTPVLPFGYGLHYTNFSLSFQSTKTAGSDIATLVNNAGSNPDRAAFATIVVNVKNTGGKANLASDYVGLLFLKSTNAGPAPHPNKQLAAYGRVKNVGVGATQQLTLTVNLGSLAHADTNGDRWIYPGTYTLTLDVNGPLTSNFTLTGTATKISTLPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BP77</accession>
    <name>A0A2T4BP77_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1406780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679152">
        <property type="protein sequence ID" value="PTB71123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BP77"/>
    <dbReference type="OrthoDB" id="5289641at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697:SF1">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB71123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19315" checksum="382E04A008CEDC5A" modified="2018-07-18" version="1">MTEKTDDSSTTCTQYTPETTEPTIVGEPWDGRRYAVPWPGNKYHIFINDTDRAICANDSGGVYVYDINSDVHQQYTWLCVEKNGYFGFNNTQTGRYIGHNSHDLLRAEAWNFEAWELMTVRKHPEGGYELLSPHWWHTLKKVTVLAGSDELVLRQHGTTLWQFVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQB5</accession>
    <name>A0A2T4BQB5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1451856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679148">
        <property type="protein sequence ID" value="PTB71498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQB5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="152" mass="16949" checksum="5CB1795F8D8EC902" modified="2018-07-18" version="1">MASLPRCRCLSRQSAYLYLLIQGGRLKPEENKFSDGQELIKNFLALDRFPSQQAEYGPVRTVRMKSAKEHKVSWSWNYQGTKSDDLNLEHDTRWPMSLAGFLTRRAGGADARLPPGRCTSSKALTAVLIASPPYFGFPEPQIVEALSGLAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQL2</accession>
    <name>A0A2T4BQL2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M440DRAFT_1395514</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQL2"/>
    <dbReference type="STRING" id="983965.A0A2T4BQL2"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="370"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PTB71576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="719" mass="77427" checksum="F699090E13C8945E" modified="2018-07-18" version="1">MEAIKQTFQRCKAQGRPALVTYVTAGYPRPEDTPGILLAMERGGADILELGAPFTDPIADGPTIQTANTIALKNGVSIESTLGMVKEARSRGLKAPVMLMGYYNPLLSYGEERLLKDCKEANVNGFIVVDLPPEEAVSFRKLCSKGSLSYVPLIAPATSDTRMRILCQLADSFIYVVSRQGVTGALGHLSSNLPDLLSRVKKYSGNKPAAVGFGVSTHEHFQSVASIADGVVVGSQIITTIQKAPSGQHEAEVENYCAYLCGRDARPVFKDEVGLVQDAPGNQGATAESVSVEAVVTDEDRMTAEQDSALVAQLAALHGKIPERFGEFGGQYVPESLMDCLSELEEGFNKIKDDPSFWEEYRSYYDYMGRPSRLHLAERLTEHCGGANIWLKREDLNHTGSHKINNALGQLLLAKRLGKTKIIAETGAGQHGVATATVCAKFGMECTVYMGAEDVRRQALNVFRMRLLGAKVVAVEAGSKTLRDAVNEALRAWVVDLDTTHYIIGSAIGPHPYPTIVRTFQSVIGDETKKQMQEMRGKLPDAVVACVGGGSNAVGMFYPFANDTSVKLLGVEAGGDGVDTARHSATLTGGSKGVLHGVRTYVLQDKNGQIIETHSVSAGLDYPGVGPELSSWKDAERAKFIAATDAEALTGFRLLSQLEGIIPALESSHGIYGAMELAKTMNKDEDLVICLSGRGDKDVQSVAEELPRLGPKIGWDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQL7</accession>
    <name>A0A2T4BQL7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_212022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQL7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB71584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="228" mass="25182" checksum="F66C3A46A5D3A593" modified="2018-07-18" version="1">MDGRLGWCRSWRPFGSPETNWLAVLSVPRRCAGCLCLCSCLSMCLHRGLGNRRDKDTQTRTLSAGRITTATAPCFARVSNIWSEPWVQWLSTVPASPYRLLIIKSFRCRYQWMLRDARSQPDRGPPHLRGSWGFARHRLFSGHAARLRPKEKSMRGDVGATVQYGDSGAAVPWAYPPIGRSLATDAPSLVLYDTSCTYSERGLFRALGFKGAVTAGEAPATRAGAAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BQS6</accession>
    <name>A0A2T4BQS6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M440DRAFT_1466219</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679147">
        <property type="protein sequence ID" value="PTB71635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BQS6"/>
    <dbReference type="STRING" id="983965.A0A2T4BQS6"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PTB71635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="334" mass="35092" checksum="C11DF01237F7452F" modified="2018-07-18" version="1">MDAVDVSEHYEVTAADNSPSLLSIVLDTNPRAWAALDSSISLAQAICDILVFANAHLAFSNTNQVAVIAAHVNRAVWLYPAAPRQQPSSSTTTSKDHSGDVQMQDVSTEANAPPPSANKYPQFAQIESSVFSSIQTLMAETTVQDLDQLTTHLSGALTLALCRINKAAQALSSSDTTLSNAAPVNATAPPPVKGRIVVVSVSDSDPSQYIPTMNAVFAAAHNQVAIDTIALAGDSTFLQQACFNTNGIFLRAANPRGLLTYLMVVDTGYVCSVCLSIFCSPPNNAECLTCGTVLALGNYGAKPAVLPRKKKKKKKIANGSGREETGSATGTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BRQ7</accession>
    <name>A0A2T4BRQ7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1343023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679144">
        <property type="protein sequence ID" value="PTB72002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BRQ7"/>
    <dbReference type="STRING" id="983965.A0A2T4BRQ7"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="366"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="538"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="913"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB72002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1246" mass="140538" checksum="03AC27B307CA2962" modified="2018-07-18" version="1">MADYQYNSRAPPGQQRPRGYPDQNGNYQRDAAFSNIFGAAPPPGRSQTMTSASVPPMLDQGRTHTMSSASGMHRQPPPRPGQGYYNEQQPPRPRPADNHMANGHYPGQRSASGAGPQQVPSSQAQYLQQQHQQARRPYPGPPGAPPPRFDSRGPPLPSGGPRGPVPRLHQPGPGPALNSDPYRSQSLAAMPRPQMYPPGQNFQQSSANQFRQAPYQHAAQSRTTAQGRVVPERHEDRTMSLTGIYHPREGDGQQTMSGRIIPNRRAPAELAQGPGYPAHNGYAPMPGTQTRTASMASSTGGADHARTFSMASTTSTIAPSESDAGTLVQRPSRSKSIESERPTTATTKIRPPLVYPALLSRVAECFRQKINVGDRTKNELTYKNAFSGSEAVDVLSYIIRTTDRNLALLLGRALDAQKFFHDVTYEHRLRDSQSEMYQFRETLMDEPEGKNPVNGVFVLLSECYSPTCTRDQLCYSIACPRRLEQVSRLNLKVNPGGLRKEDSANVNDEEVDQTDEQKLWINSVPKEIADAVDEREKKRQEVISEICYTERDFVKDLEYLRDFWIIPLRSKASPIPLQRRERVVKNIFSNIIDHPSVHGVSSRFASSLTTRQQKDPIVHNIGDIFLEFVPQFEPFIYYGSRQLEAKFEFEAERSINPFFSKLVDEIERRKESRKLELNGYLTKPTTRLARYPLLLENVLKYTEDGNPDKEDIPKVLTLIRDLLGRVNAESGKAENRFNLRRLQEQLRFRPNERVDLKLTEEGRELVFKSQFKKSPTDPAELTAFLFDHAVLLVRIKQTGKTEEVKAYRRPIPLELLSIREMEEVIPSDGGVKRSASSILPVIRPNASEAKKGEGWPITFRHLGKAGYELTVYASNQAARKKWLEYIDAAQQRLRARADFFTTNVISSNFFVGTNRVNCVSPFDGGRKLLYGTDNGIYMSDRKNKDAVPRRVLEAANVTQIDILEEYQLLLVLSNKTLQSYSLSALTSDDPALAKKPKKIQNHCSFFKSGICMGRHLVCCVKSSTLSTTIKVFEPNDAMTKGKKQKGLGKLMGGGFDELRPFKEFYIPTESSSVHFLKSKLCVACARGFEVVSLETLETQSLLDQADTSLDFVARKEGAKPIHIERLNGEFLLNYSEFSFFVNRNGWRARPEWRIDWEGSPQSFALSYPWILAFEPNFIELRNIENGAVHIVPHKNIRMLHSSTHEILFAYEDERGEDVVESIDFWQSNRRSDVFGALPPSQSAQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BS37</accession>
    <name>A0A2T4BS37_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1405864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BS37"/>
    <dbReference type="STRING" id="983965.A0A2T4BS37"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB72122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="350" mass="37435" checksum="5C369F8E371066B2" modified="2018-07-18" version="1">MAIPDTYKAYRRTAGEDPLTITQTTETTPKSLGPKDVLVKVHSVSLNYRDVAMLHGRYPISILDKGIPASDAATEVVAVGSDVKKFQVGDHVSPNFFLNYLTGEETGGRQALGGDVEGVLGEYAVFKEDVLVKLPEYLSWDEAATIPCAGVTAWTSLNGLKKLTPGKSYVLLEGTGGVSMFALILLVDAGINTIITSSSDAKIAQLEKLSPLVTGVNYKTHADVGAEVQRITGGRGVDVVINNSGIGNIPSNIESVGSHGDIAIVGFLGGWDADWSPSELLKLIFKSASLRGIGVGTRLDFENLNAHLKERKISLKTLVDKVFAFDEAKEAFDYLYAGRHVGKIIVKVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BSA1</accession>
    <name>A0A2T4BSA1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1465899</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679143">
        <property type="protein sequence ID" value="PTB72191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BSA1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="821"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB72191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="916" mass="103226" checksum="F2BED3521F6F6E04" modified="2018-07-18" version="1">MSAEEPCIDKSPEEGNSPQEKAFEEKSGLPTTVHAAEDSENKFTEKLGDISNSTAPLNDIEYVMDKIETLSVEECKDIIRDLLKHHEYDYNFSESQRKKLAALIDGPSENQGAEEWELELKTEAAINKFFSPYPEVRAITTPTDDVNIPCETIRAHLLGYMWAVIAQFTNSLFNSRFPSITLGSSVAQILLYPCGLFLAWVLPDWGFTIRGQRVSLNPGPWTYKEQMLSTIIIDVGLTSAYCFWNIQTQTVYYQDKWLTPGYGILLLLSTQLMGLGFSGLLRRFVVYPVEAIWPNILPTVALNRALLVPEKTETVHGWRLSRYKFFFIFFSGMFVYFWLPDFIFPALSYFAWMTWIAPNNFNLNIITGSTNGLGFNPISTFDWNVLSAYSYPLAYPFFAFFQQFLGTLLAGLIIIALYYTNTNWSAYLPINSSGIFDNTGNSYNITRVIGAGTGILDENAYEQYSPAFYSAGNLVVYGAFFAFYPLTMVFIILDAWRPLLKAYKSMANAAISSTKKILTGLKNTALSLARGDVQGAGRHLRSINDESSIYDGFDDPLTNLMRSYPEVPDWWFLIIALVAFIFAIIIVTHWPQLNTPVWTVFFVIGLNLVFLIPMSYLYSISGTTEGLNVVTELIIGYALPGHPEALMFVKAFGYNINGQADNYISDQKMGFYAKVPPRAMYRGQVLSAIITAFVAYGVVQFADTQIPGICTPDQVSSFNCENGSQVYFSASVVWGAIGPKRIFSQIYPTIKYTFLLGFLLALLWWGLKRFGSYIRAASQAALPAYIHRPIDIAVFTPISWLKHVHPSLVFNGMLQWAPLNLTYFTGGLYFSFAFMYYLRRYKTSWWEKYNYVLSAALTGGVAFSGIIIFFAVQYHPKNISWWGVDVLGQTIDGGAGQQTLLTQLPAKGYFGPDTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BT52</accession>
    <name>A0A2T4BT52_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_158484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679141">
        <property type="protein sequence ID" value="PTB72489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BT52"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB72489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="78" mass="8580" checksum="DC88E74BE70390C5" modified="2018-07-18" version="1">MTTSTRLHKHAASHPSARTVTALIPVFTLFFLYFSTSPSLSDVRFMELLERSPTAKSVYDVTGAPPSTNPAVRTRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUD4</accession>
    <name>A0A2T4BUD4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1448410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679140">
        <property type="protein sequence ID" value="PTB72908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUD4"/>
    <dbReference type="OrthoDB" id="4202165at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB72908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="116" mass="13215" checksum="85BAA814BF627293" modified="2018-07-18" version="1">MPGHTFNIWTVPLEAALTAVVRLICAEARSSSLRRGFRAHLASLLGYNFFDMSYEGDYEEIIGNEVPLSESELLEIESAVAKIKAWEMRDCEEWIKENLIKMVSCSMTGDQLPWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BUH9</accession>
    <name>A0A2T4BUH9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1404694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB72970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BUH9"/>
    <dbReference type="STRING" id="983965.A0A2T4BUH9"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000060">
        <property type="entry name" value="TBC domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="106"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB72970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="39327" checksum="90E06706C6EDA92D" modified="2018-07-18" version="1">MSLEKEPADHAGLRDDDDDDQDQDQDTSRAASKEDGDGDAVDSPAVALKTSEILAACTWRDATRLRALAESEGGLLADSLRRAAWPILLGASPPANETKPVFLLVLEPAARAPLVARLSVLRIRDFMLPSLSATTAQLRLIPDILARADPDLRRHLSSIEPFYALAGTLTMYAHNIERYRDIARLFDVILAREPTFSIYLFAQIVIDRREEIFEIDEPDMLQVILGRVPPELDLDGLIKRAVNLFTDHPPETLRSWHHISSSSVLKTCRDVDASTRQTLEDGHRFFERQVKEIQWQELRMGVRRKMWVYRRPVKYVGAAIVVGFVAFYLRRNPSLVQYIWSFFPGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV10</accession>
    <name>A0A2T4BV10_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1472430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV10"/>
    <dbReference type="STRING" id="983965.A0A2T4BV10"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="359" mass="38509" checksum="EA088EB45493FE77" modified="2018-07-18" version="1">MPSATYSRPPQQDSWFAPLSIDLIIKVLNVSIFHPFICWLIPLCLRAQTTRWEAPPMVAAIAWAIFVSLMWIAGAVNQRIAHGAPREVDLGEEVIVVTGGASGLGMLVAEVYGMRGASVAVLDVNEMENGEARGVTFYKCDVSDKAQVAKVAVEIERDLGTPTVLINNAAIVVGKPLLDLSIDEIETSIATNLLGPFYCLKTFLPAIIRGGRGGTIVNVSSVIGHLGAAQLTDYAAAKAGLTALHKSLAAELRESHPDIRTVLVTPGQLSTPLFYGVQTPSGFFAPVVEPVDVTKEIVAAIDGGRGVTAAMPFYARWVDWYNVLPVGVQLLARKVSGVDRGMKTFIGRRGSGEEDKKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV31</accession>
    <name>A0A2T4BV31_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Developmental and secondary metabolism regulator VEL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Velvet complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M440DRAFT_1340338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV31"/>
    <dbReference type="STRING" id="983965.A0A2T4BV31"/>
    <dbReference type="OrthoDB" id="5384689at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034250">
        <property type="term" value="P:positive regulation of amide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043455">
        <property type="term" value="P:regulation of secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000001">
        <property type="entry name" value="Sexual development activator VeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="12">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="222"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PTB73183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="558" mass="61370" checksum="D90F3B488CF55EB6" modified="2018-07-18" version="1">MATPSSVASSSSRDQFQRIHRVTRENRHLWYQLTVLQQPERARACGSGMKANSDRRPVDPPPVVELRIIEGPSVEEGKDITFDYNANFFLYASLEQARTIAHGRVQNGATNNPPILTGVPASGMAYLDRPTEAGYFIFPDLSVRHEGYFRLSFSLYETTKEPKDFDLEPADSDLPPGVDWRMEIKTQPFNVFSAKKFPGLMESTSLSKTVADQGCRVRIRRDVRMRKRDGKGSGFDRREEEYSRRRTVTPAPAEDPNLRARSVSNASEHRAPYMPQEPPRRPSAAESYHAPPPLPPPPPPSYDAPPPAARPGHLGFGDHNMPPQYGAPAARPYGHPQSAPIPPATPTGPYPTASASPSPYAKHDQQQQHQQQQYSYNARPAAPSASPAPPMKHAIYDNRPSEPYAPHSSSGYASAERRPSYANYSAPAPYSTPPTYSAPPPAPYSAPAPYSAPAPPPPRPSMSQSSLAPLKIASLVSPLPPIEAQTEPLPPPPILSTGGKRKHDHVFSQNHKPLYNGQRQLDAHYGHGYRGLTPEPDQGLYSRADGQIGVVTFNQYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BV64</accession>
    <name>A0A2T4BV64_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_144415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BV64"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="106" mass="11710" checksum="A94497F179F36E3F" modified="2018-07-18" version="1">MAHAAACAVQYVYAASSATSSMLLRVKEPPFQNIMQMLCCKLEGKKMEFIASRRSPILEKLEPPRNSRLVDSASPFQLGVSWVPSTFARVVLAATIIAHLWGCQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVE0</accession>
    <name>A0A2T4BVE0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1340192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVE0"/>
    <dbReference type="STRING" id="983965.A0A2T4BVE0"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB73259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="822" mass="90854" checksum="E61ED7B11DECDC5F" modified="2018-07-18" version="1">MAETSHNPYPRSPNPSTRSYDSSSVSSATSPRPTSRYLGSMLNAAARPAASVGMTSLPPVNQGFPPYTPMAPTSIMGRESVASTDSLVSSQGPGSSQLSGTPGAQGQKRAYRQRRKDPSCDACRERKVKCDATETTSCSECSSRNVKCQFTKETNRRMSSIKQVQDLEKQIEKVKRDNSNLRRMLQEKGGAMDMDVEPRDRPTSHLPPPIEAESRPRKRQQPVPNLAQARANLRSVSKGVFKPPAQYRSSPPAVFDTPAPELPPRQVADQLLNTYYTTAHTMFPIIHLPTFKSMVEDLYRARQPRLTPAFLCLFFAVLATGSLFTVEIPATAASYFRPAELLDSARKAMDPWCNHHTLDDARALVLITICLNEMNLKSAAWNWLGNAVRVGQDLGLYIDTETWPVIEGEMRRRTWWAIYILDRVMATEMGHPFLIDDADCSVALPAAVDDQYIREDGMRVPGGAEPLTHSLLAVIHVVRSYTSIMKTMESPTIPPTHLANFDAHFKKCLHTFPPACDPLSTVALAPHFLAPLTYLFHARLLLHRHNLNPSCDPETRLRAIDSCMHIAMETASLLNRTESPAEGATSLLTAHIFRSALFLLFTENWDYAIICIRALAAIDARRDMATACGRYLAFFTSTLSVKRADYSSRLASTTSPHAYSAPQSPMNSTLMLSLARDEELLAYVSSDLHASPSRSWVWNEGHDHDYLSPKLDSPVPSGGLGHALFSAAMRTGLSEEERREWGGWSQLEAAVRALGTTHATSNWTTLPPPQVKRESPTPGMPSIQRLSDAPRYTSETPKYGNEPSRPAASPAGRDRLSIANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVE2</accession>
    <name>A0A2T4BVE2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1362580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVE2"/>
    <dbReference type="STRING" id="983965.A0A2T4BVE2"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="442" mass="49245" checksum="5E2627D521611FD6" modified="2018-07-18" version="1" fragment="single">MSRGTVQPNGWVAIRLPSDTTRVLQVIPNTTISLGKYGSFPSNLIIERPYHLTYEIQDKLEGESFPRLRIVPGTELNADKLADVSAESAEGDEVIEPANGEQLTLIDEESGKVVARSNREVIDESARQTLTMAEIDQLKKEGASAGKELIAKLMLSHTAIDQKTAYSLAKYKLLKEKKYMRRFTVLPLDVAQLGHWMLVERDASKIMEMRQEMIGLLGCWADVHFGGLPIEGAQSPHGGRWLAVDDTGGLLVAAMAERMGLLHADAPEEEETSKDAAQQEQNPDAQPNSEEAGAEPASTKPQRNRPKRPRKDDLDDHYALTNSITLIHANSQPNLSLLRHFDYDFSDPNPPYPYHPLFTHLLPISWLQLLDPEADPTYAELAPAVDPEVLASWKTNRRANYHRKRRRWARTRQIVDATRAGGFSGLAVASTMDPVSVLRHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVF9</accession>
    <name>A0A2T4BVF9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF431-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1393912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVF9"/>
    <dbReference type="STRING" id="983965.A0A2T4BVF9"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB73303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="207" mass="22939" checksum="BAB9DEC36DCE710B" modified="2018-07-18" version="1">MASTGKTFIVEHLDPELGPWSELEYLAIAAESEETNAKFILSCLPPDFKVPPALSASKAFTAEHRGVEELYAGQKSRVCLLDPAAAKDLAPEDGETFDAFLFGGILGDDPPRDRTSELRKKGFEGRRLGAVQMTTDTAVRVTRMVVQDKIPLEEVPYLDFPELHFNEHESTQMPFRYVKGADGKPIMPKGMVELIQKDADKSLDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVG8</accession>
    <name>A0A2T4BVG8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_1315520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVG8"/>
    <dbReference type="STRING" id="983965.A0A2T4BVG8"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="53" mass="6045" checksum="8BD63D4A8AE236F5" modified="2018-07-18" version="1" fragment="single">DYCDVYLTHDSMSVRKAHNSGRNHLRNVVDYYQQIGHEKAQSVIDSITSSYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVI2</accession>
    <name>A0A2T4BVI2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M440DRAFT_1472486</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="KZ679139">
        <property type="protein sequence ID" value="PTB73256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4BVI2"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
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        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
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        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
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        <property type="entry name" value="Fer2"/>
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    </dbReference>
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        <property type="entry name" value="Fer2_2"/>
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        <property type="entry name" value="MoCoBD_1"/>
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        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
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    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
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            <begin position="257"/>
            <end position="441"/>
        </location>
    </feature>
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            <position position="1290"/>
        </location>
    </feature>
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        <location>
            <position position="64"/>
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            <name>[2Fe-2S] cluster</name>
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            <label>1</label>
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            <position position="69"/>
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        <location>
            <position position="72"/>
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            <name>[2Fe-2S] cluster</name>
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        <location>
            <position position="133"/>
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            <name>[2Fe-2S] cluster</name>
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            <label>2</label>
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        <location>
            <position position="136"/>
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            <name>[2Fe-2S] cluster</name>
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        <location>
            <position position="365"/>
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            <name>FAD</name>
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        </ligand>
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        <location>
            <position position="388"/>
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        </ligand>
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        <location>
            <position position="450"/>
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        <location>
            <position position="789"/>
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            <name>Mo-molybdopterin</name>
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            <name>Mo</name>
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    <sequence length="1367" mass="150018" checksum="A243367856B047F1" modified="2018-07-18" version="1">MAPIAISPERDGQLDSLASLTAKFDDTLRFYLNGTKVVLDEIDPEITVLEYLRGIGLTGTKLGCGEGGCGACTIVVSQFNPTTKQIYHASVNACLAPLVSLDGKHVITIEGIGNTKRPHPTQERVAKSHGSQCGFCTPGIVMSLYALLRNKSSPTTDEVEEAFDGNLCRCTGYRSILDAAHTFSKENSCGKAKTNGGGGCCMENGNGKPEGGCCMDKLSNDQPIKRFTPPGFIEYNPDTELIFPPALKKHELRPLAFGNKRKKWFRPVTLDQLLQIKSVYPAAKIIGGSTETQIEIKFKSLQYPVSVYVGDIAELRQYEFTNDHLEIGGNVTLTDFEHICEEAIKRYGHERSQVFKGILKQLKYFAGRQIRNVGTPAGNLVTASPISDLNPALWGANAVLVAKSAAQETEIPLSQFFTGYRRTALPADAVIASLRIPVTAAKGEFYRAYKQAKRKDDDIAIVTAALRVKLDDDGLVRDCNLIYGGMAAMTVSAKSAAEYLIGKRFAELETLEGTMSALGNDFDLQFSVPGGMASYRKALALGFFYRFYHDVLAILNGQSDHIDKDAVDEIERAISTGQTDPHTAAAYEKEVTGKSNPHVAALKQTTGEAQYTDDIPPLRNELYGCWVLSTRAHAKIKSIDYSAALDMPGVVDYVDRHDVSSDAANRFGPPNFDELFFADGEVLTAGQVIAMVLATSASKAQEAARAVKVEYEDLPAILTIEEAIQQDSFHPCYREIKTGDVEEAFKNSDYVFTGTARMGGQEHFYLETNACVVVPSPEDGAMEIFASTQNPTETQTFAARICDVPANKVVVRVKRLGGGFGGKETRSIVLTASVALAAKKTKRPVRCMLTREEDMVTMGQRHPFLGKYKVGFNKDGKIQALDVDLFNNAGWTFDLSAAVLERAATHVDGCYRIPNTWVRGRVCKTNTVSNTAFRGFGGPQGMFVIETCMEEAADRLGIPIEKLREINFYKPLEPTHFNQPVTDWHVPLMYKQVQEESNYHERKAAIDRFNETHKWRKRGIALIPTKFGISFTALFLNQAGALVHIYHDGSILVAHGGTEMGQGLHTKMTQIAAQALQVPLDNVFISETATNTVANTSSTAASASSDLNGYAIFNACQQLNERLAPYREKLGPEATMKDLAHAAYFDRVNLSAQGFYKTPEIGYTWGENKGKMYFYFTQGVAAAEVEVDVLTGASTCLRADIKMDIGQSINPAIDYGQIQGAFMQGLGLFTMEESLWLRNGAMAGNLFTRGPGAYKIPGFRDIPQEFNVTLLKDVEWKDLRTIQRSRGVGEPPLFMGSSVFFAIRHALKAARKDAGVEAIVGVNDSEGLLRLESPATPERIRLMCEDEIMRRARVVPKEGEKGFFVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVM3</accession>
    <name>A0A2T4BVM3_TRILO</name>
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        <submittedName>
            <fullName evidence="7">Sulfite oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1464842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
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            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="PTB73362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:sulfite oxidase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
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        <property type="entry name" value="Ig_E-set"/>
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    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
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    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
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        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
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    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="188"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="395"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB73362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="571" mass="65350" checksum="8FA8CD0DFA15F491" modified="2018-07-18" version="1">MAQVAKPQVKLEKTSNREDEWKIEQGLAGAELPVLDMTKPQTEPLVPQVFGPCTKDEEAIKSVGDPNKLFTREREGWVGFVEWENYPDKKAAAHKILTSQTFPPNPEFQLGPIPGTNPVLPGTHWKLWHHAVGGELTNIPEDSWSTVLKEKHPDMLHLLQFPYNGEPPKRLVTDKEITPNPLHFVRNHGGIPLIDKDKYSFVLDGLVAKPREYTLDDLMDESRFPRMEKIITMQCSGTRRIEQILKYPGQGDEVPQAPWAEGAIGTAKYVGISLKKVIKECGGLIEGAKHLEFYGADTYFKDDKTMNYLVSIPYSKVKANEVMLTWEMNGEPLPAIHGYPLRIMVFGYIGARSVKWLYRIKAIKQPSRAPVQSQEYLYFPQQVGKHNFKLTDGIQIQEMPVSSAIMSPWHKQVCIHNGEIRCKGWAYSGGGRWPERVELSSDGGFNWYTVPVDKLSKKRRWTWRTWEFELPCDPEGWVEIVCRCWDNALNTQPPDVRTAWNWGLHVTSSCHRISVYSVNKSRPLTRARLEEFDKAGIPFGPITVPLAFPAQTWEDYEKYWKTHDPRDAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVN6</accession>
    <name>A0A2T4BVN6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-terminal binuclear Zn cluster-containing/DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1441036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVN6"/>
    <dbReference type="STRING" id="983965.A0A2T4BVN6"/>
    <dbReference type="OrthoDB" id="5376052at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="758" mass="84177" checksum="28837896D9FAECB7" modified="2018-07-18" version="1">MAEDDTNSASSHDDGSSADETTPAVASSPQKGSEQVVGKKRKRAKYQKTSCELCKARKVKCDRAEPACSWCARHNRTCVYLERQKPGSRIGFSLELEAKVNRIDALLQSLGRRVEEHIANDHLPSSQTQGLSPALTSHLPSPADAYHLDGARLGPVGAVRSTPTLRPGLISPSWDANGADNYQDARMPPLANSSSPVVNSSHAQTYPTSTFSASRRGPSSISAVNDFPPHDIVYTLVDLYFKHCNPWCPILDRKTTFGLFFGSTSLNEPDRVLLHAIVATTLRFLKDPRLSPEMRAHHHAVSKRTVQMYTMENVSVPALRALIILSLDELGTSNGPKGWNLLSLLAQNVKQLGLCEESSVYLSVQSDDLPHTGSIRRVTAGRPDSWIEDEGRRRMCWMVYLLDRYATIATTTFDFMLEDRKMQRVLPSSYDLFSRNVPVETRSWLSTSQPYGTTGYATNKPENLGSFSYHCEILRILSKVHDFLKTPIDITSSPDVASWRNTYRSLDSALDGWLRSLPSDYSKISALCHSDPGSRVANWFMLHGAYVTSVVRLHSSAAYPTVRSHLFIPSYYAMQRCLSAVQSLADIARDVFEASGLDNLGPPFIFGLWVAARLLLVHAASIGCPVDPKIEFFIEILGHIGQYWEVASNYAKILSRAVQRGRQGDMNFTAMRRSAHDLATLISSTRQSGSEPTSTQVTSLSELDNIDIFDFFNYPKLLEPRSANGQSWHTQGVNGLTGESMRMPDPESDWLGYNSQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVN8</accession>
    <name>A0A2T4BVN8_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1060015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVN8"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="190" mass="21200" checksum="E173938E3EC4D6AC" modified="2018-07-18" version="1">MPVAKALGPHLSPLCLLREGSIVMSRRSFHTSSRYSLGWRTPPSKSIKPLIVHLQAISSHNYLPRNQEPHNVVAGRHAALTLQQSSLTYLYLRFGSSPYRMNPNMPHRILLTQPSAPCAIVIPQLPFSDRKGGQHWMQAAAFDKQLHHQQQSASRIVPAGRGRPERRTRAQCRPPFCPRPACSIGHGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BVR2</accession>
    <name>A0A2T4BVR2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1382452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BVR2"/>
    <dbReference type="STRING" id="983965.A0A2T4BVR2"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB73391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="388" mass="43194" checksum="531458CC65F3DAEA" modified="2018-07-18" version="1">MSQKINNLPGTALPPKSLLGYHRQLAPAAAVKVSPLCLGGMGFGTAWEDIMGRCDKDKSFELMDYFYSQGGNFIDTANNYQNGESEAIIGEWMKARDREEIILATKYTSPWRLAEQDKRIQSNFGGNNKKSLTVAIEASLKNLQTSYIDLYYVHTWDFTTSIPELMHSLHNLVVAGKVLYLGISSTPAWVVAKANEYARQKGLTQFSVYQGQWNAAEREIERDVIPMCIDEGMAQAPFGVLGMGYFRTSAQRAAEKEEEEREGRKVAFVDKPQKTVMADALEKIAVARGTSITSVALAWVRTKAPYCFPIVGGRKIEQLKANIEALAIDLSKDEREAIESAVPFHFGYPQEFLGGAKGVVYPQDAWTTKRLGHFDWVTPPQAPKPHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWJ4</accession>
    <name>A0A2T4BWJ4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1067486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679138">
        <property type="protein sequence ID" value="PTB73635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWJ4"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="101" mass="12323" checksum="E08AA8763B61DEDB" modified="2018-07-18" version="1">MSRTLFLFHFGSCFPIPFYFFPFMLLFHYLRTWYIFRVHLKGGEVVKGEKRRRFRRLDSTRYQISRRLFRIAAGVFRMRTRNNRPSRSNGESACMCARVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWK4</accession>
    <name>A0A2T4BWK4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1360401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWK4"/>
    <dbReference type="STRING" id="983965.A0A2T4BWK4"/>
    <dbReference type="OrthoDB" id="3925971at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="384" mass="43728" checksum="AB0DB4A27F359B13" modified="2018-07-18" version="1">MSRSTFLAARNSRHRTAALALYRALLRTASRIPLAENAPKHPLAQIVRKRFSKNTGYKSYRLIYAAMAAGYKFLNLLTRAQTPNSPEHSQVLNHLQSVRSTTAHSRTKPHPKQYKRAPPPEPLLINVAKENEPPKYTSNILPRPKESLKGPRKVPSVSATADGQPFVRLKKPQPYTLSKMIGRKGRIFSNRIENIMDLDERVTSEAALEDEWDRMMDDLLAKESGQGGKRRRTVPYSWDAEDDAKMETFGWSVQLSRLWWEWKVEKTWEDWIARGDALQELVEQERALAEREEGQSNAASGRRNRTPRRNPLDPDDSPPNVGVSTVQAMPLLDIARDIELPSDSKQVQDGGAYDPFLSPSWSALVKAQERRMLNWTGRRAERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWK9</accession>
    <name>A0A2T4BWK9_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1299213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWK9"/>
    <dbReference type="STRING" id="983965.A0A2T4BWK9"/>
    <dbReference type="OrthoDB" id="5311469at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015511353" description="Extracellular membrane protein CFEM domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB73690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="28416" checksum="F8B4E5C22635CC4F" modified="2018-07-18" version="1" fragment="single">LFLSLAPAALAVVEADFSFYPANAQPCLNQAAAASKCVGSTVTDLNNCLCGNWNDFVILAATCLGDKDKDDAVSVYKTMVSACADSDTPLDVSPSEFYGAVNGETTTTTTTSTTKPTAATTTATQTDVHVHSTVTVQPTSSSTSTAAPAQGSLSTGATIGIALGASFGGVGSIAGLVYFLLRRAKKQDEERHPMLPHNYSSEVKQSSSWVSPLQSPDYRYSAATWDGAQGAYQGPLAPTGTGGEMVLPLQAQGMNGGVEGSGGGGTGMVFEMDATASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWM4</accession>
    <name>A0A2T4BWM4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1393601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWM4"/>
    <dbReference type="STRING" id="983965.A0A2T4BWM4"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB73720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="205" mass="22804" checksum="296BB1955AAF51C6" modified="2018-07-18" version="1">MAPSLRSRKRKEVSEVVESDDDLSGAELEGILSQSEDDESDVEDTGSEGEEPELDEDEDEDDEEADLRSDDEQAEKVNGETKTNGAEEEDDDKPNYRVVKDANGGVRYEYEEIDPVYDSDDTDAQGPVNTIGNIPLSFYDSDDGTLQIFHGKVVGDLMENATIVPVKQLRGHKVDKKLGVMDIDWHPKHPWIVSAGADMTCRLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BWU4</accession>
    <name>A0A2T4BWU4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein YmL11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1403908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BWU4"/>
    <dbReference type="STRING" id="983965.A0A2T4BWU4"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB73716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="36690" checksum="5FF92E93E39880CC" modified="2018-07-18" version="1">MTRILSRAARPCLRRLSLEATPVRGAFAFALGSHNFSTSEAQRASPGLRSLPEGVPLPIDVVPATKPPSARPIDTRKSQLIRTYTSLLRTTPLILFFQHSNLTAVEWAAVRRELKKALEGVPPIVPAPGAEPLDLSPLVQLQVLRTNMLNVALKLVEFYNPEVAAASKSTKRTTKGPIVHDLSEAAYEQIKNVEIPPNSAYAQIEPLMVGPLAGLIIPAVSPAHVAAALSVLAPVPGKFPAPTRRKNPGYYDPTFQNGLAKLVLIGGRIEGKVFDQAGVQWVGGIEGGLDGLRAQLVAILQGAGLGITSTLEGGSRSLWLALEGRKGQLEDEAKGESKGEEPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX29</accession>
    <name>A0A2T4BX29_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M440DRAFT_122671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX29"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PTB73867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="674" mass="74236" checksum="CC39B972E40DD62C" modified="2018-07-18" version="1">MAASGEQAPLLGSDLRSIPEPHDIATTLLKHNHHHDCLDDDEDADSAPAGSGTRSAGVARMEAASARLSPMERFWVFSGIFLIGYAYGLESQVRSTYMPYATSSFSLHSYLATINLLRSVVAVAVQPTAAKIADVFGRFQVVAASTLFYVVGMAIESTSGSVYSFCAGTILYQIGYTCIVLLLEILVADFSSMRARVFFSYIPALPFVINTWISGSITSAVLRITTWRWGIGMWCIIYPVASLPLLITLYSIDRRTALRPDDKSELGQTYKDLRNWSVRFFDQVDGIGLVTLVTTFSLVLTPLTIAGGTVSHWRNPQVVIPLVIGLIFVPVFILWEKNGARNPLVPFHLLTDRGVWAALAVRSLLNFAWYVQGNYLYTVLIVAFDFPIESATRILSFFSFFGVVSGVAVGLVIYKFRRLKHIIVIGTVLFMVALGVLIRFPGGATSTSRAGLIGGQILLGLSSGLFAYPTQASIQASASRDHVAILTGLYLSFYNVGSALGTCLSGAIWTQTLYPTLEASLAFQPNTTLARAIYENPFHIVSQYPVGTEIRDAIIHSYESIQRLLCITGMFICLPMICFALALRNPKLHVSERTVTFGDTIPLRILYLIDRLTAIASDDYRLHQFFLSRLSTPATDLQPLSHADRLDFSYRPRQTEQTRGFSDHSRKSASSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BX45</accession>
    <name>A0A2T4BX45_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1404022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB73824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BX45"/>
    <dbReference type="STRING" id="983965.A0A2T4BX45"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
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    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
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        </location>
    </feature>
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        <location>
            <begin position="368"/>
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        </location>
    </feature>
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        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PTB73824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="454" mass="49911" checksum="4C8D2D5D1B20605C" modified="2018-07-18" version="1">MSSPAAPPPDAAAAAAAAAAFHQFTVEAFTLLGVGIFVTVLRTAARVRFGGWRNLSGDDYLAWLAVLFYIAETCLAYSVGNKANGLANNNMTDEQRAALSPDDPEYHLRVLGSKIQIAGWSTYSTLLWTLKTSLLFFYIRLTDGLARHYRIRIYIGFGLLAGSYITVAMNLYLSCRPFHKLWQIYPDPGNVCYPAVSNQIIWVYWTFNVLTDMYIISVPLPMLWGTSLKPWRKIGLIFLFSGGLFVIVCATLRSALITLDTANGAQLAGSWAVRETFVAVVTTNLPMLVPMAKVLLGPFIGSILSSRRSTQKLDDGTPKSLVTFGGSTKSWRGRGPPTANPITNFTISESEERIVEDVRMQDLKVWSDGRDHQGDHHHQQSRADEESGSREIHKHVEIDIVTTSQRLSEEQRQMSSDEHARRLRGAFPFPGGGNGEGGDGNSNGSGMNNGMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXL6</accession>
    <name>A0A2T4BXL6_TRILO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M440DRAFT_1338424</name>
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        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
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    </dbReference>
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            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="54" mass="6178" checksum="77B7070BA9614527" modified="2018-07-18" version="1" fragment="single">KKPRKSRHLHLASPTKSKLSVPISPQAKHRHHEGSTSVTTTYISVYMNLVVTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXP6</accession>
    <name>A0A2T4BXP6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M440DRAFT_1393871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679137">
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    <dbReference type="STRING" id="983965.A0A2T4BXP6"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="130" mass="13975" checksum="1A4BAEE8E49257FC" modified="2018-07-18" version="1">MALYDLNIAWSPATPTDRLLQTLTTAHSLGYTTSEKAMEGLRTIPRGVVVNEGLKRDGFRGVVNIVQVVKRKPAAEGEQTDDQSSAAEQGGKRKNQKRKNGGEDAQPVSKRGAKKMKLAARAAAAEKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXQ7</accession>
    <name>A0A2T4BXQ7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAK-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1039438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="82"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB74119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="312" mass="33951" checksum="92561DDFA19C46C9" modified="2018-07-18" version="1">MVTPRIRQPLGALLTLPKQQPRPLSAFEDFNESSSYTPHSRPTSFTSSSEASSPRHTMTARPPTLNEILLDTAPPPWSLSAFMAYLSQNHCMETLEFTLDSQRYAAVYEQTLSEPNPSDDCRERVCAWWEKLMQVYIIPCAPREVNIPAQVRDRLLRVPCGPDPPHPSELAEAGRIVYELMNDSVLVPFLQSVAPSAADLHHDFHLASPKASSDRSAASMGTDSDTLTADSSGTSPSITEPMTPPTTPPTSEWTFAASHGGFHRAVAAHNKGWKKVGAALGFNRKSSSRRTTPTSSGPESGESSYNSSGSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXU3</accession>
    <name>A0A2T4BXU3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1058870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679137">
        <property type="protein sequence ID" value="PTB74092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXU3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXU3"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB74092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="368" mass="41132" checksum="C71FFF849A30DEA8" modified="2018-07-18" version="1">MYDDDDTTFSLVSTASVTDATSVTTRTELELDHADDETEAEAGFAGVNDASSDFESGWEVSSGPSTSVPPSVYEDEIAYGRRYHGFRRGIYPMPNDEVERHREETVHALFLQLMGGHLFYSNIGGHPQKIIDIGTGIGIWPIDVADQHPSASVIGTDLSPIQPSWVPINVRMFIEDSEEPEWLHGSEFDLVHFRQMTDVLRDLKGLLTKIYPHVKNGGWVEFHELMTEIRCDDGTMKDDDPLRVFLDTVKDGLRVYGINILAITDIEQILRETGFSNVHCITKKVPISTWPRDKTLRALGVFMKTTINDSLGAMAAKPLAALNLSPEQRVAMLEAARESLEDASIHRYVNCCVCYAQKREGDFGDSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BXX3</accession>
    <name>A0A2T4BXX3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1393300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BXX3"/>
    <dbReference type="STRING" id="983965.A0A2T4BXX3"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="343" mass="37247" checksum="4F2003544F3E9783" modified="2018-07-18" version="1">MAAGSSSTVVSQGRTHDETTHIVMYVFFSLALYNVGELACHVAVTFKRLRGLYCWSFLEVVISALYIRETYRILRSYRGLVGVNRRTMWHVILINLVIIALDVSILVLQYTDHYDLQTAWKPFAYSLKLKMEFSVLNRLVELSQYMHRHRGIALIEAPTARGAPLPLLMVTADEAGTAAATPRRSGGGGGQDVSAMSTVASSIEPKAVYHHHHHQQQQQQQQQQPPAEASAAAEARVEAPPNVLQLEKSSLQCLPHSIAHAGNPSCWIPEACGTFGNDKSIPSRPASSSPPPPLLPPRPHGPELRRASRAAGAAIFGDSDDDGGGGGLVDVDDLPPSYEASTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYL3</accession>
    <name>A0A2T4BYL3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_21191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYL3"/>
    <dbReference type="STRING" id="983965.A0A2T4BYL3"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="730" mass="79921" checksum="E33F971E5C874875" modified="2018-07-18" version="1">MASPPPPLPARAVSQLPPPPPLPPRDTSQLPPPPPYSVVDESRTTPASQNQGMPQDAQILRSKDPRASSSQSLAPSKSSSDARRTLLLVYIHGFYGNDQSFQSFPAHVHNYLREALSETHVVHSKLYPRYKTYKAIEVARDNFSAWLEPHESPTTDVILIGHSMGGLLAAEMVLLPNGNAPSQYPFKHRILGTLSLDSPFLGLHPGIVSSGIASLFQPAPPSPSQSATSSSTPDAQLADIRPAASATSIDSPLGGPRDPNFDPPFFNDAPFREQPFLTRMLNFSTKHWSEGIFTALGHHVTSHLEFGGCLADYRGLMSRYNQIRALEDVDDLQAFSGDVAGNSHPRVRFLNYYTLASGRPKPTASAKGSRDISQVDLSTSSVSESHVADEIDKKLVGITLTTADDERVDSAPTDLPKPSTPVHENAMDGPVSASVPIGKISVKNADSGSELEEPNSSLDLNRLSMQELEPIPISEDEQAVVEQSIETTMTTSSDRPSPSIEDTADGKRSLSEQASTSPEPDLPRIPDLPSPPPQPDLSQYTDKDSRKQAEKEFSRLQKAYDNAVKDRTKALREREKLLKKRQKKAQKDADKLEKDTKKQEQKEAKQEQKRLEKEAEKAIKAEKKRQDKDGAAQAKRIESNSKSAPTPETPETQPKPRKPRKFCNTPAKRDGAVADPTWVSVYMDGMDEVTAHCALFLPGPHYDGLVGDVASRIVGWVQNDSSVRAMLEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4BYR7</accession>
    <name>A0A2T4BYR7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_115953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679136">
        <property type="protein sequence ID" value="PTB74404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4BYR7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="132" mass="14341" checksum="99E76399FB09E2F6" modified="2018-07-18" version="1">MPPTAKEANTGCQWFCSNDFHRRSNADRLQPCITTFSFPSLVPARSAEMHGTSRSYLLLRAAVVHARTATPPLFPQHPGIASRAAAARDLPEGRGARAAKSLRSWEADMGDGDRAFCPHLLLRSSREAVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C023</accession>
    <name>A0A2T4C023_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1445233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C023"/>
    <dbReference type="STRING" id="983965.A0A2T4C023"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="267" mass="29189" checksum="574D13B1DF75B52A" modified="2018-07-18" version="1">MSAPPPTLLDPSIFASLEAKLEEETQIRDTLAQLVQRLDRSVATAQGLLSRVHSTPRSRYPQLVAQVEAAVKDEAAIISELDKVASQHPYYKYNYKWTRSVQHAIGTAIYCAWLGGFPPKAEEGASAEAPSSSSASKEVEIGRLLTLEEVGAIFSVPTNLKTRDAFHLTIEEYLLSLADLTSDLARLATNAVTLGDFQLPLVISAFAKDLFAGFQLLNLKNDIIRKRADGVKYDVKRVEDVVYDLSLRGLIQRPGAAGADTEMKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C055</accession>
    <name>A0A2T4C055_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1432264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C055"/>
    <dbReference type="STRING" id="983965.A0A2T4C055"/>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB74948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="782" mass="86957" checksum="52DBBF0AC39E093F" modified="2018-07-18" version="1">MSTGCVVCRSRKVRCDRNSPTCHNCNRLGVKCPGYGDLPVLSQKDGSRQRVQDSVDTIYRASGVEKRKVGSCDECRRTKSRCSRSRPICKRCMKKGFTCRYNPKYDAAAGQSSASSMMAGQDQGLTTTASSHCSGSVSSPGSQKRRTSVSLSTPIQPGFQWLFADTLPHDALHLRSLADKFFDRISTLRCLGFIHKPTFYQALDRGTLNEDFGEAVIYIVAALGARMYLLDDSTEFNASYGIPGAAWADRARDLAMREIANPSISTMMAMVLICEHSVAMDRHALAFVVFGCCLRIMRLLSLDSRKKVSDAPGLAQMTRLETERRLLWSCYLLDSFLGGGVDGNLFWKDDFPCVPLPCSDASFIAQEPCISDLNAPRLSTFEIFPDRSYLNLRSHTVYLVQLRTRVLRLIRNNSQEANVWDSGSATLDIIQRLEIWYASLPEQLVLSDLNAYVHKELSIIGAVFMLHFLYHSIACDLLRVSLPGYVFPLSAAFHSAPLEFRRQCQERCRFHADEISRLVRVGFSYGIRVFDDLHSVMATFESTKIQIIHTATATSNAIDVRERASYNIRLNMRALDILHLQKDKPNPYHKALIPLLEKFDFNNVVSEWQAYPNPISMNTEQAEVTGPEDTGFLSSLAPFRLAKEEIRAQTRQRRGTSPTVRNELPASPSTATVRPPPIISMPQKGTTLGGGGGIGNGGVLDGVEFSLDRMQLASTSASHPTPPGVNDQDASTIHGGVPKEMVDLSDLAEDYIRMAGEMSNYISWDISEPHAWLDFDMSSTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C078</accession>
    <name>A0A2T4C078_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1320236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB74982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C078"/>
    <dbReference type="STRING" id="983965.A0A2T4C078"/>
    <dbReference type="OrthoDB" id="4884755at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB74982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="112" mass="12372" checksum="C166DB80D1E6E331" modified="2018-07-18" version="1" fragment="single">MDIPRRLTSLVHVASQLCSQDTLKLVLSRGAFPDIRDTYGWAPLHLAAWNGNANAMRILMDGGANIELKKIWNQPRLYRNLITEHSGTTPLHQAAFRGHLSAVEMLLAAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0D4</accession>
    <name>A0A2T4C0D4_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAM86 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1471445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679135">
        <property type="protein sequence ID" value="PTB74934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0D4"/>
    <dbReference type="STRING" id="983965.A0A2T4C0D4"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB74934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37511" checksum="02A8A9F7D3278A49" modified="2018-07-18" version="1">MEASVQKQIDRFCRQYLQLEQTLNYPEPQYIRRSDVQEAIYQRLFAEDALPGGCPPLRYQVRVLKELISRIEASIEDWDEHEVSDGLMSSLSVLFSTPASNEDDAVQQKYPVVYHLASLPGHEAHIDLLENRALIAAGGTTGLRTWEAALHLGQLLCHDPSIVSGKRVLELGAGTGYLSILCVKYLGATHVIASDGSDDVINNLPENLFLNQLQGSSAIRLMDLKWGHALVGTEEERWNGGRPLDVVLGADITFDPSIIPDLVSTLLNLYGLYPHVEVIIAATQRNLQTFQVFLERCQQEGLKVEDVSFEIPPRDQQEGPFYNDQVAIRICKVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C0X6</accession>
    <name>A0A2T4C0X6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_66710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C0X6"/>
    <dbReference type="STRING" id="983965.A0A2T4C0X6"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB75212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="225" mass="24328" checksum="68B151348BCC7F67" modified="2018-07-18" version="1">MSTDEQAYQTGMVLTTALASFVTGYMFGIFTTRGYLISPALAEERRRYHSDPVESDESDVDVDGTPLDHAPNWANGLDADRRQGLRFRESGAAEKRSLMGESSEECKLVLVVRTDLGMTKGKIAAQCSHATLACYKALASADPSSPERRVLSRWERYGQAKIAVQVKSQAEMLELRGKARAMGLTAEVIQDAGRTQIEAGSMTVLGVGPGPKSLVDKVTGGLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C141</accession>
    <name>A0A2T4C141_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1402824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C141"/>
    <dbReference type="STRING" id="983965.A0A2T4C141"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB75290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="72" mass="8238" checksum="529C7B41C9FDB7E0" modified="2018-07-18" version="1">MARGNQRDLARAKAMKKDAKAKAGHQLDGYQLAKASLSNAEIMRQKQAKADEKRREEEERALREKKEAKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C181</accession>
    <name>A0A2T4C181_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal fungal transcription regulatory domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1402795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C181"/>
    <dbReference type="STRING" id="983965.A0A2T4C181"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB75254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="692" mass="77953" checksum="50E7386889B62125" modified="2018-07-18" version="1">MPNYVPITPRPAQDSNGTASGSSETTENNKRRRVSVTVACNTCHRKKTRCDGKRPVCSACESSQSNCTYRDDSGLSEESQSLLQEVIRTLNSLPDDQVLERVRSLKREVDPSAILARLRGRSVTQQPNGAAEQNMMSDAFQTMELGPQFPNVYPPIPKLDMDTLEDAPYQQLIHATNKKPGEPPQGGAEAAAEQAQSLCDSRLEKLDISRWTNVNISNEYAARAISLYLETDHPLLGFFEPNQFVSDLIAGKTDHCSRLLVNALLYWSCQLYCAQDLESGSLTLAFCSEAESILNDERGNDSLLNLVALQFMSLGYLGQGRDTVVLTYLNEASEMAVRMGLFGVAHNQKQEEMSNLSEPERSAHLYAAWGSFNWITHMSLFYRQPGLQCPKAPPRLPIPGSQENQSQQSESESSSSSSPAEPDPPYMGGVFAYICQFWSILHELALLYRHKGPLKGDRRTLCFAEFKFRELLAWSNRLPRRLCRNDQSPHYVQILHIWLHAAILDLFRFSMSSNLKSLQLRTFTSPYSTPENVCIASARQLKQLIMNYRLNFASSSYTILWHTALTYLANAILQNPKEENWFFYFLLCVYGYERLRPCWRVTQAISTALISMALGKGDITSPTARQLLHDVSDNKGYQLPGDVRATFMMDLDLAASDPESASVEKIAQDFDQNLLLQQYTNIFDKRQKTDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1F6</accession>
    <name>A0A2T4C1F6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M440DRAFT_1335454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679134">
        <property type="protein sequence ID" value="PTB75334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1F6"/>
    <dbReference type="STRING" id="983965.A0A2T4C1F6"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF4">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="989"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PTB75334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116611" checksum="2B88A778197823AF" modified="2018-07-18" version="1">MTGPEGVRAKGRIPKYRTSCDNCQTAKVKCGHEKPSCRRCSVHRVDCVYSLSRRMGRPRAKKVAADASNHGPSAATSEQSGNANPKAVTPEDAAEGARPPQTLAAEGCGAEAEPAEPLVSEAGQIPENWAPLFGDLGQLNATEAMDGLEGSEQQEDDPMEFLSTESPMELGDMAFDGIPSFLNSLSGSLEPQATTSTVPAELFGSHEMLSFALPDASVKGDHASARPSTHQQHQASSSSESCTCGHSAKPSRRDSASAPSARDESNQLPNLASILFSEASYSPQEVSSCSPSNASQPSDTSPSVQTSCDGHSSEPSWRRTQVVLRRGNCSCMATITERIASLKAEQQSSCFMPMDCVLMLEQEVQESLSLLHECRNCRLDSVVHLLALVSVRMMLNILQKTARSEFVSRPTSPSGGSYETIALCIGGYRVPGRVRCRFLRKALQARFHKLAALVEERESLVTGKKQDSFSKSASLLLVADGVICDQFELIWVAPTVTSDHTKPMTPVYKSTSKPQDDNRQRVNSGDVAMEPSHLHNTTATTTLGYKLQSALDRPFATAAVTILISIVSIAFLDWLNYQHQRSRLGKIPIVGDAPYLWKRLRWTENESNLKGVFQRGYDTFSKKLKPWAYWGQHDDFILVLPPGTCDEVKNADPSQMSFLQAVEDSYHFRLHTNILGRAHVDAVRQSVNKNMNQEPFAGFLQIWHLVHLVAASFLIGPHFARDPDYMGYIEDYCLNVPHFVHLYFWVPAPLRKLFWYLSPWGFRVRRVIKNLKSFIIPELKRRIADWRANDRNQSPDQYTLLRAMLDLKEERGQFARDATAMTRQEEERQINIFSDEVMFTAFDSAGPVACLVTQLLFESIQDPSLTEALRAEISKALADNGGEWSVQMMSSLPRLESFTRETLRVDGPTLFSVTRSILKPFQLKSGLVLRPGNIISAPSWMIHNDEDNYPNAKQFNPYRFYDETINTATVKATTASNTFLAYGYGSQMCPGRYLGVRMTQIIFAKLLMRYDATFEGGKRTKPENIVMPGQVLPSYYSKIVLKLREGGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C1T6</accession>
    <name>A0A2T4C1T6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_324515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C1T6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="249" mass="27091" checksum="6B0133B26C3D6D04" modified="2018-07-18" version="1">MPSCSASSLWRLKPRAAPGGWFSPTADCPKGGGETCSGDWDLTSAACRYVQKIPWHVVWGQSSVGGQAPHRRDLIACFHYPDLGAAQRREEADDFGGKAESQYYRYHGARHGAKAALEDEPLAPQRQGYRRALRSLVLPAALHESASWMALSTSLQRRLTPLFWIKSLMLGSLSCRAAALASREGVLIMGSLPPPWMSVGRAPWQRAAALRSGATSHCLVSSDLVFVVAHNIVCHCPLSIFHSQTSGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2A9</accession>
    <name>A0A2T4C2A9_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1335210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2A9"/>
    <dbReference type="STRING" id="983965.A0A2T4C2A9"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="297"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="593"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB75692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="636" mass="71042" checksum="F052C2CDF860DCE3" modified="2018-07-18" version="1">MPFDLVGKTLSPFLKEHIPGQYAPVGKNLKKEDVTGTSNALANIKDPNTKYCYRHRPDSKCRRAADETKMGTIQRELNSLPSADQEAITHVWSLFSAAPAKHRELMLQGIITQCCFPQLSTVSREVQEQLKIDFIATLPVELSYKILCYLDTVSLCKAAQVSRRWRDLADDDVVWHRMCEQHIDRKCTKCGWGLPLLERKKLMAWSRHQQTAHANPPNHADEASAEPASTPTAEGSNKRAMVVRNDSATKRSRVNKAGNGRAQLNEERKFRPWKDVYRDRYKVGYNWKTGRCSIRTFKGHENGITCLQFDHNILATGSYDTTIKIWNVETGECIRTLRGHTSTIRTLQFDDAKLISGSFDKTIKIWNWHTGECISTLQGHTDGVLSIHFDGCKLASGSIDKTVKIFSFDTKQTWTLRGHSDWVNHVRIDSASRTVFSASDDLSVKLWDLDSKQCIKTYLGHVGQVQQVLLMPPDFEPDEDPNADRGDAASASSGRGDSPSPLPDQLADRRAAFGYGFTSDPARPLPPRYMLTGGLDNTVRLWDIATGKCIRSMFGHVEGIWGLVGDTLRVVTGANDSMTKIWEPRSGKCERSFTGHAGPVTCVGLSDSRMASGSEDGEVRLYSFEGNSLEERGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C2N5</accession>
    <name>A0A2T4C2N5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1392331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679133">
        <property type="protein sequence ID" value="PTB75836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C2N5"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB75836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="154" mass="16472" checksum="DF6CA3C031D64F92" modified="2018-07-18" version="1">MGFGCGLQLEIGVGVGVFLVRLVDPIPSGRSAPQAPFHVSACFGDRVAKRRDAKKGTGSLGNFGNYLFSIVSESELVVGHEDLAKDPVDRGNATSIRTIRAVGSVWLQRLEALGGSTVSHRLVSVIARREQPQSSFGQWLLLGLIDMIMDPILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3D5</accession>
    <name>A0A2T4C3D5_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1355611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3D5"/>
    <dbReference type="STRING" id="983965.A0A2T4C3D5"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB76018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="217" mass="24393" checksum="B5595D3155F54F5F" modified="2018-07-18" version="1">MAEQQQTPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYMATLGVEVHPLGFTTNYGQIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPALEFVAAPALAPPTAQVDEALLAQYKKEMDDAAALPLPGELSDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C3L5</accession>
    <name>A0A2T4C3L5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1311796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C3L5"/>
    <dbReference type="STRING" id="983965.A0A2T4C3L5"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="172" mass="18361" checksum="E6263299D1CC47F3" modified="2018-07-18" version="1" fragment="single">MASAAAARGLAPNASLPAKVQPIPPNQTIYITNLPSAKIQKQDLRTALYMLFSTFGPVLDIVALKTMEMRGQAHIVFRDIQAATQAMRSMDGQTFLGRPMKIQYAKSKSHFVAKLDGTFKIPSTTAGAATVEQTELQQSIFNAPPPGTAPEKPAAPAANQAAKNPEADENRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C462</accession>
    <name>A0A2T4C462_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1356239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4C462"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1278"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB76343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1828" mass="203672" checksum="1F6D8FCFD346BAB0" modified="2018-07-18" version="1">MTTLTPEQRELQLVESVEFKILAVANDEEKLCDLLGRYLAPIILKAESSNPAVRVKVIQLLGRLRTFIQPPSVVLPVKALLTQYKTTDSGIIKQLDLPFIQHSLSRVDEDDRRDLIPIALKGCSKDEGQARAGPFFNIILQLLFDVRIPSRGSKEDEGFRAAMGLDDASDAQYLAKKLSVFLRLRPPTPGRTLAESNPTLSEEEARFFSVEGPGSDRIFQNISQLRAKVVTFLASAAFTDEEKFLPALYASSSPDTRVASLAEEIIKRTSVSLEEEGLVKRLFEAHARLPAAYRTRILALLSKSTIATGMSESIMNVVKLDFLPESTQEASTNPLKPSSALEKTKLHKALFQFLSWVAQAGPSNKDFSIGPNLIKSMQSYIESQGWPVPAQQVTHDELQLRSRGYETIGMLARSADLPYKERIALAAWLFQSLSEDTTNDAVVNIDGALSSLTGNIPEHIADEDPELRNMLLRYMYLPEKAPAVRSTRHAVVKWANECLPFNNIYARWINFLAVAGRLNERSDVVEQGQKGLDPWTYSAHSEIAPVMPDWRMMVLHYFSKPINPAPADESQPGPGATALPNSHIFDNFRSSSIQAFALVVQYCKQMMFLTALEDFKVQPDWMQALSAQIKTNIKTRDKIRGYLKYVDSSFIEIYLSACLLGAFVEDAPITEECLRSFVDVASLTPRVVVGHFAKNSATKLLPLIKSNKAEIRHLAARALGILGAHPVVDVDEVQNTGTTLNALFDKATTAVGPDLNAAEGALAAYGYLCSRSVFYNHAAVAEWKYPLQILVEESIPPSLFDAVVDAFTQLWLAKLAIPPKEGATSLDNVIKKLSEKAKKGNEKAIVALGMLAASIPDSELAESLASWSEGPVGTILKELFALHENKRVEVQFTVGDAITIATARWDSDYVKLIVDVEYRTRDFQSKCRTSLLASVLDKLFEDCKATKPSLLKASGIWLFCIVQYCSGIHEVNSRLRQAQAAFMRLLSSRDELVQETASRGLNLVHERGDEQLKAALVKDLVAAFTGSTTQLKVDEETELFEPGALPTGEGSSVSSYKDIVSLANEVGDQRLVYKFMALAANAATWSTRSAFGRFGLTNILSDAEVDPKIYPKLYRYRFDPNTNVQRSMNEIWKALVKDSKTVMDVHFDAIMEELLKSIHGREWRMREASCAAISELLTGVPFQRYEKYYREIWAKAVKVLDDVKGSVREAAFRLCRSLSNTLARQLEEGTHEASANAMMKEALPFLLSDKAAESSVQEVQVFAVITIIKVARHGGKHLKPFIPEMVPKLLGLLSTIEPDRINYYYQQVGEDSREQIDKLRSRMVNASPISEAIDNILRFVDEDVMTELAPRLEETIKSAIGLPTKIGCSRVLTALFTRHTNEIKSVSIQFLELLGKQVLDKNDEVSQAYARAAAYIMRVVSDSAKQRFSERMLKLYLQSEEESRRQKVSDVIVALAKVSPDHFTTQETILLPFAYLGSHDVDEYTSKAFREVWDQHAGSNRTVVRYVPEIVDLVERCLATTQWALRHTGAFTVAAMVSDVASASDATGAIAEANLKAIWPVFEKTLALKTFPGKEKLLEAFPNFIEKGQSLWRFNSEIAAQMKKIVIREAKRNNDEYRVHAFRCLWRFAKAVDSFDIFQDIVDIVTPYLEDHKDDNKMDVDSQEVTVTKTAMNGLEAVARGYSRSSDRRAYAVASQVIKALEPFLSSPKFSYIKREVWYEAVIDLMKDLATSEPPAESTTLDNDGVLQAYLGSLDVDKAEVGVESQRLKRADAVSATLKAYTSGVFGKSVAPLDEFEAAVAKAKEEERVPEVQKAWQRVLAELKEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4T6</accession>
    <name>A0A2T4C4T6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1356700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679132">
        <property type="protein sequence ID" value="PTB76570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4T6"/>
    <dbReference type="STRING" id="983965.A0A2T4C4T6"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB76570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="246" mass="26629" checksum="865EB83E6E3A5A68" modified="2018-07-18" version="1">MVQAVALILGAGPNVGTNVAKAFAAQGYNVAITSRSRKDDEDDAKPHLHIQADLAEPSSIEDIFATVIRELGHPSVVVYNATSYSLTRADTLQEQIAAFQRDNNVNIVSTYVATQLATRSFAILPPESSKTFIYTGNKQHLMVIPPLLSQGVGKSGSAHLLHYLTEQHKNSGHKFYFADERKSDGSPVYGDISGPAHGAFYTALAAQKTQGPWNATFVEYQGYVAFRENATSGYTADKSQVCQTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C4Y4</accession>
    <name>A0A2T4C4Y4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1332783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C4Y4"/>
    <dbReference type="STRING" id="983965.A0A2T4C4Y4"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="142" mass="15940" checksum="E177AAB6D1C7E074" modified="2018-07-18" version="1">MSHRTSRPKPPPPGNEEAGAVLNLGEFQDVDTLTLSEAALVLNALVAKRRNDRKNINETEMLNQTLNYLDHFARFTQKENVEAVERLLSAHKNLAKFERAQLGSLCCENADEAKTLIPSLADKISDEDLQDLLDEISKLQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5T7</accession>
    <name>A0A2T4C5T7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M440DRAFT_1401233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5T7"/>
    <dbReference type="STRING" id="983965.A0A2T4C5T7"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PTB76888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="114" mass="12924" checksum="D45E226DADC47980" modified="2018-07-18" version="1">MVVKIRLARFGRRNSPFYNIVVAHARTARNSRPLEVIGTYDPIPKPDPYDNSGKLHKDIKLDSQRARYWIGVGAQPTDTAWRLLSMVGILPKRDFAPKENEPKGSVKAGDVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C5Y2</accession>
    <name>A0A2T4C5Y2_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyruvate formate lyase activating enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB76976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C5Y2"/>
    <dbReference type="STRING" id="983965.A0A2T4C5Y2"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB76976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28374" checksum="2CB0F7A2A634CB08" modified="2018-07-18" version="1">MRCIFCQNYDIAHQRNGMDLTPEALAEWYLKLQDVGNVHNINIVTPEHVVPQVALSILHAAELGLKLPIVYNTSSYDSLASLELMDGLVDIYLADFKLWEPSTSKRLLKADDYPQTARESIKAMHRQVGDLCFTGDGIAKVGLLVRHLVMPGKEAEGAEIMRFLASEVSTDCFVNIMEQYHPDAHVGKKKRRTKASGSAEEAKSQTEQDEGGSDVRYGDINRAVTNEEVSLVRKAAMEAGLWRFCDPPKHGGFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C643</accession>
    <name>A0A2T4C643_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1401374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679131">
        <property type="protein sequence ID" value="PTB77025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C643"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="98" mass="10222" checksum="61494E230D0E0CCD" modified="2018-07-18" version="1" fragment="single">TSSRNDAEEAEAAEMVRMREEKKSGREEGEEAGAGAGAEASLFSLQALQVVGGAGALLCPASIGFSSGSKPGHRKKKRERQVDASLMGMKKENARVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6J2</accession>
    <name>A0A2T4C6J2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1390558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6J2"/>
    <dbReference type="STRING" id="983965.A0A2T4C6J2"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="111" mass="12180" checksum="143707E79770EEC4" modified="2018-07-18" version="1">MASPLKKQPQDVADCVLKRAEVSKTNRARMERPSTPPPKNSKLDLPSAMMTTPGGGNPFPNTPGQGFDFADFVNITPSPAQKVWKTPNPLTGARTPRSVARKRLTFDEPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C6N7</accession>
    <name>A0A2T4C6N7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1206752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C6N7"/>
    <dbReference type="STRING" id="983965.A0A2T4C6N7"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB77215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="349" mass="38818" checksum="B36176837A11D85A" modified="2018-07-18" version="1">MSSSGLTRRRGAGGGAGTEGESSNGVSRTNSTRDARDSAPETSYESGENGHKIAFDPRDISESAERSKQPKLTMMEEVLLLGLKDKQGYLSFWNDNISYALRGCIVLELAFRGRISMEKDPARRRFPLADRNIEVIDDTLTGEVLLDEALKMMKQSEKMSVSSWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKEEIRRRVRNVLTQRTVVLNGSQFLPENLEFRYLRTVAMVCAAYAANVLENALSSLGHEARERAFAQTDELLADYSQFPFGKKATGNGIGANLPQVIAEEVNKAKDKELQLEIVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C760</accession>
    <name>A0A2T4C760_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase, subunit VIb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M440DRAFT_1400275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C760"/>
    <dbReference type="STRING" id="983965.A0A2T4C760"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PTB77358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15153" checksum="9EA52A3915A3014C" modified="2018-07-18" version="1">MGWWPFSGDTRADAIRSGTAIPTRQERAVCWAARDAYFACLDAHDIVDATKDASAAARACPQQSADFERDCAAAWVKYFKQWRVADVQKKRRLEELRRQGAVEMEVATSFAPEGGAGEKGKGKGDIQEMLDRKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7B1</accession>
    <name>A0A2T4C7B1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1421205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7B1"/>
    <dbReference type="STRING" id="983965.A0A2T4C7B1"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="253"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB77423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="531" mass="57282" checksum="CF4642C7A7A7F6F3" modified="2018-07-18" version="1">MPVETDGPARVNKGKGPATHTRHASIDGNMLAGGHPRSSGSPFPSSSTQQRRPPANSAGRLSFHGERRSSETVFSQQSTQSASSGASHPPIAAVAEAASSATVEREDEHPVEEETTNARAKERARKHYRRQSTKRHDSPSRLSNPKDYGVQSPQDPPRGPAYHHPFNGRPPMPNEAPMNDAGHPRFPPIQTIPGNFPNGYGSPEGPFAVPEPPPVFVPSPMQASFPPIRPPPPHPPPAPPLNHQLNGPPLSGYELLAAKLSGNLAGPRLAPIYRRFESLHHRLLLHMQDELIEMEEQLHSLDAVDTENRKFPGGIYPASRRGENMSPTDATWKKKEIMTHLAHKLYQYNQVMTSFGATHVMAEPSIKDVFDYKAYLQDINPLVEVECQFLDAADDLVNLVRRRRRSNGNPQDDPLSPMPRSSSVVGFPPPPSSQISNAGSSLYPGQGAAPPSVKGLALAMAMIVLAPIICFSVIPGFVGRMTVVLLVGLGGAAALLQSGLFALVAEERSTLDWILCAGLYGGVMAVIAGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C7Q6</accession>
    <name>A0A2T4C7Q6_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C7Q6"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="80" mass="8401" checksum="A83FCAF6392986B3" modified="2018-07-18" version="1">MPPSTESCLAAGVAVSSAHLAHSARGTCPDQKAQGSMTSPSRRPFKSLVTVLDKGRGPLPQGRPSWCIGDLAHHWVLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C831</accession>
    <name>A0A2T4C831_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1469612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C831"/>
    <dbReference type="STRING" id="983965.A0A2T4C831"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB77730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="266" mass="29983" checksum="B784964A58A531BF" modified="2018-07-18" version="1">MPHCVLPPKSGKKVAPAPFPQSKAGKKGPKNPLIEKRPRNYGIGQDIQPKRNLSRMVKWPEYVRLQRQRKILRMRLKVPPALAQFQHVLDRNTAAQAFKLLNKYRPETKVEKKERLLKEATAVKEGKKKEDVSKKPYTVKYGLNHVVGLIENKKASLVLIPNDVDPIELVVFLPSLCKKMGIPYAIIKGKARLGTVVHKKTAAVLALTEVRSEDKTELSKLVSAIKDGYLEKHDQVRRQWGGGIMGAKAQMRIIKKQKALEAATKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8P7</accession>
    <name>A0A2T4C8P7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1400840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8P7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB77892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="130" mass="14073" checksum="256C7184C82EAB05" modified="2018-07-18" version="1">MAPTMPRFCRSLPDFSYYQIFAPSPLDYPQTLRCPTAVAPPCNSVCTMPCPTLPIFFLAPAASCSASSNMLALARQERARSRAMDTLCYDALPLQNKVATGSPFPGEVRVPSPATGVGRVRAPTPKRPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C8S3</accession>
    <name>A0A2T4C8S3_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_1229389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679130">
        <property type="protein sequence ID" value="PTB77977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C8S3"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB77977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="185" mass="20528" checksum="6996083AB02A44CF" modified="2018-07-18" version="1">MLVGAHSTSIEQAANSWTGLDWTTFKPAAGLVTSPDRFHNADTVRVGTPVDSRTIRASIGAARKWLEWPPSATMRMHPRGSGQATGWAITECNSLRRSDRWRLVPFLVPCLVLPKVVTWRCSIPNCYHTEDSWPHRACMAVGQSAVAQPGSEAAHELNDVLLQAKRRVKANRRSLFFLRCLGSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C951</accession>
    <name>A0A2T4C951_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1399253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C951"/>
    <dbReference type="STRING" id="983965.A0A2T4C951"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016486246" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="31"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB78075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="331" mass="37828" checksum="51F5629FE0DC27E2" modified="2018-07-18" version="1">MTASYGGRPGFRAISLMLLVVALFVGASFASVGDQLSEFKQCLDICKAENCAPGKATPIPLSRRLLLWDCSSECDYACQHIITASRVASDLPVVQFHGKWPFYRFLGMQEPFSVLFSLGNFWAHWQGLKKVRARIPAGYSLRPYYEAFSYFGLASWVFSSIFHTRDFAATEQLDYFAAGASVLYGMYYTLVRICRLDRPSPRRRSVLRAWTLLCIVLYACHVGYLKGVSWDYTYNMAVNVVLGVIQNALWSWFSFDRYRKSRRVWAMWPGLAVAWVMFAMSMELFDFPPWKGCIDAHSLWHLMTIGPTILWYNFLVKDANDDIAGSDRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C952</accession>
    <name>A0A2T4C952_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M440DRAFT_1372420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C952"/>
    <dbReference type="STRING" id="983965.A0A2T4C952"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PTB78106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="534" mass="59072" checksum="823800AECEB50532" modified="2018-07-18" version="1">MSSSPIEVRPHPSKGRALHATKDFPPGAVILPFTPLLLLPTVSALTSVCSHCLRPGDPRLCSSCHAAAYCDAACQAAAWKAVHSRECKALTKTIRDEERRRMLPTPTRALIQALLWGKIRDGLADLEGHVLEKRAEGDAWKDIEMMAVAGCAFSGLGRGDQDVRRAAEMLCKIQNNSFQRFDPDLNIVGLFLEPTLAMANHSCIPNAAVQFIGRDALLVAENPIRAGDEIEIAYTFYTDPLPKRREALAHYMFTCQCLRCRENLNVYQVAAISPCVNLNSQSLVPDVSKFRNHPATTSTTKQDIINQHGESAEDMADALAEVESPSERRKLLKSEYSKKKALVEEELWAVTPLPDILYRISMLYSEEENYAFALAVACLVATACDPYQYPSPYHPIRLAGLFTVANLVSHTAAATASQTSSAVPVSNNATLEQEMEETLREIDQVSLCQMLLIMILRYLPDGYGAETSLAVKARALLDDIEKLAGREKETSLIDEWRRDPSSEKSQAFFEFAVVKQVDALASLGKQVLRRDFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4C9W3</accession>
    <name>A0A2T4C9W3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1420462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4C9W3"/>
    <dbReference type="STRING" id="983965.A0A2T4C9W3"/>
    <dbReference type="OrthoDB" id="5429395at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="361"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="710" mass="77223" checksum="3DB680890AFB2F4D" modified="2018-07-18" version="1">MSKSLGSAFSMLSSAPPAAQPENERPSSKRMQQDGQGKYQLFPKGRQSPVPSNNSSVDPDTAFALAMNSNKNTEKLGTIPALKVKMNQQPIARRRKANNIPDLGPMTTVQEAAMDSPTIPGLPALRERAATAPQESSRDPSGPLRLGKATYTPPKQTDVQRRPVGSQPPRLPSPKRLAPLVIPEPQQLSFLHDVQQPSPPPMLLRTDSAPRLGNGPSHFLTPISSSTTSDASRPPSSGSAIVNSATTGPTPISAPVLEPRSATTKQWEPVSRTPLSATRPDEGSSSHRRLASDSQGAHDRGRTKKRGEQHKKSNSNPVNPHTGRGEKKRSKSAEQRAFEELPSGCRPQQAVSQMSANDLGILRQQALGQAERFEVLQVEDVERLSKELRKLDERVEYLRRTYNSLRNGRRNFHSRICQYLRSPMRGSRLSADSMLRQEEALAELDASIDGWVIKLERAENRRTRVRQKLLEHIAAAAILNVAGETQSPLQSTAAPPSTPLRPASPLQVRVVRDIATPPRSPDGPTSSRPVSASPPPLRVVAQVPSMILELPAEEVEAQSTTELTRTTTMKSSDGESIRIYAGDELFALLTDVEDEIFRMNNATPESSSSPNSSTAPDFGATPEPVALPVSDENQTEYLRVGQKQSRSNLRLSAQPDSPTLAAPPLMLKSTFYRPATPNDQPPSPPAPVPPLKDVPKDGEVFLTSAVFKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CA39</accession>
    <name>A0A2T4CA39_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Adenosine deaminase-related growth factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1329593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CA39"/>
    <dbReference type="STRING" id="983965.A0A2T4CA39"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="347" mass="40335" checksum="44DC8A0421EC8C57" modified="2018-07-18" version="1">MAQKTTLKEFESVYPKLEEALLDHARSYKLPEKELNWFKKNLEVNPLGGKCNRGMSVPDSASVILGRPLTEEEYFKAATLGWMTELLQAFFLVSDDIMDSSITRRGQPCWYRQEGVGMVAINDAFLLESGIYIILKKFFRDHPRYVDMVELFHETSFQTELGQLCDLLTAPEDRVNLDNFSMEKYTFIVIYKTAYYSFYLPVALALYLLDIATPQNLQTAKDILIPLGEYFQIQDDYLDNFGLPEHIGKIGTDIKDNKCSWLVNQALQIVTPEQRKILEDNYGQKDDAKERAVKQLYDDLKLKERYEEFEEKRAAELKDLINKIDESQGLKKEVFEVFLGKIYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CAD0</accession>
    <name>A0A2T4CAD0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1329313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CAD0"/>
    <dbReference type="STRING" id="983965.A0A2T4CAD0"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PTB78527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="399" mass="43180" checksum="91B870CA519147F4" modified="2018-07-18" version="1">MPFRAPLPVQQQFRVPLSPSHSRQFSTPTGQCASIRTRTRPTIIDTPLRAAAPRRSITSRPRPPPFPTISTCPSPTCACAETPAMPDGLEIDHANPLNGVMAGYAEHVVVCTGKDDWPSRIEDENGGDNLAADLKELFGRGGKYTDPFHHISVINSSFPSSAPPRKAVQSTSVYLLPSFKYVPLLPRVSFDSVKALAKGFLLPERLHPAHAGLSPAHRDRLTRKAAFQGLLPGVRDVRDVLVLICGHGGRDMRCGVMGPVLRSEFEDKLGRKGFTVAREAVPVGNLEEEEENEMMMKRVEGRSSSSSSGGGGGGEMVARVGLISHIGGHKFAGNVIIYIPPGFTAEGGERHPLAGCGIWYGRVEPRHVEGIVGETVMAGRVVEDMFRGGIDAHRRILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB38</accession>
    <name>A0A2T4CB38_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_269044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB38"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="79" mass="9183" checksum="C3E63DFFB56523C7" modified="2018-07-18" version="1">MSASRRRLYPSQQRASCEIRSGPRLTRRKDRLPPPFSGHNLEYKLKILWRRAVLSFGRFYFVAWCILSFATNGGGFSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CB52</accession>
    <name>A0A2T4CB52_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1437586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CB52"/>
    <dbReference type="STRING" id="983965.A0A2T4CB52"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB78748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="308" mass="34417" checksum="3D9793241C14860E" modified="2018-07-18" version="1">MSGLAKPIPALYAVYVLRSTVRHASIYVGSTPNPPRRLRQHNGEAKGGAVRTSRERLRPWEMAIVVSGFPSSIAALKFEWALNNPHLTTHIPKEERITVATQRKKSGMPRRAPHTLKSIVSNLHLLTRVPSFARWPLNLHFFAQDAHRSWERWTKASKIPVAPSLRILTDFGPSAGDSSTPPLPPWGIHALALDYSPMKEYIKKAHDAESFERQGRCLHCDAEMHPNVGLYAMCPNEGCEAMGHVDCWSRHALVGDDAGAVIPNSCRCPSCSGEIRWGDMMKELSLRTRGAGEVEKLLRKRKRAKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBA5</accession>
    <name>A0A2T4CBA5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1202821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBA5"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB78849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="342" mass="37314" checksum="A5C5ECF8253C9F5A" modified="2018-07-18" version="1">MVWPAAEPLLKPSSSPIVESPSPSSSSSSSSPSASYSESLPLHSNSHHHYHHQQQQHHRPPQHQNYPQKSPSPTPTQTTQDWHHHRQRQWLDRIPYDLPPQHSLLLPEPSSSSQSSVPSTARGFVVDMPGSYYSRSNSPSAEEQAMFHLAHDSSPPSSHQPPTNNNSIGLLSPPPSSFSPIQDPFSPIPSAQSHTSSYEQSPPPFTNISPSTQPATPQQEDHTYHRPASPISLADSQPTLCQGRASSEYSSRASPIPRPTVMSHIHSHAYAHGRSGSEYGSGSGSGSGRESGKGSRRYPRTAEETEAQALSAVVEGIGRMQVNMNLDQAGRWRIARRADAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBF1</accession>
    <name>A0A2T4CBF1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1329585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679129">
        <property type="protein sequence ID" value="PTB78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBF1"/>
    <dbReference type="STRING" id="983965.A0A2T4CBF1"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="108" mass="11479" checksum="AADE22470E8D170F" modified="2018-07-18" version="1">MSEQMSAPRITASYLDSFVGRVVTIVGTVTQLRGDQATIDADGIVTILLNRDAHLVNGNAAQVIGKVNPDLSIKALSTRDVGSGVDMTLCSAVAELTHRHKEIFVSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBW7</accession>
    <name>A0A2T4CBW7_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_227139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBW7"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="132" mass="13776" checksum="E7BF993DB8AA0211" modified="2018-07-18" version="1">MQMACTDGYAVQPGVAGCSQSRLDTAGSQKDVLSVALRQVRPKAGEGATREEEMHSRQGRARGEGTKSGEGRETVEKPGKASRRSCRRKAHQGASPSSVPSSPVQSAQSSPVRPSATGSGAVDAVDAYSFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CBX8</accession>
    <name>A0A2T4CBX8_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CBX8"/>
    <dbReference type="STRING" id="983965.A0A2T4CBX8"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="59751" checksum="594EAEE0385FA49B" modified="2018-07-18" version="1">MSSPPSTSSNSSPPPDSISSSPSSGSSSSKDSTLAAHLALLSLDTSNEDADELAATPVFTKPVLDYGKKLKASGNGEPFPQYGLLAGILKDGQSKVGEEDVRLFFNTTAPSSVFICGSQGSGKSHSLSCLLENFLTQSKANVLPHPLTGIVFHYDPLGGSPCEAACLSSAKDISVRVLCAPTNSRDIKAIYSKLPGVVVEELRINQSDLDTRKMMELMAVSSVQGGGIPLYLHVVQRILKDLRIEEQLNGTTFNYREFKRRLISETLAPGQLVPLQQRLDNLESFMVKEQVVQIAKKKALQSQGNGNSWESKAGQLTIVDLSCPCVTEETACSLFNICLDLFLQHRADAGLVIALDEAHKYMTDTVESAVLTEKLLENIRVQRHLGIRVIISTQEPTISPKLLDLCSTTIVHRFTSPAWMQALKQHLAGASIAPLEEICDEDDDDDFDHKVVKPGLTANELAIEIFSKIVALRRGEALLFCPSAIVDVRRSVTKLEKNPFDNDDGVKLEEGHEKKKTSSQLVKLSHGHLKIRVRERVTRDGGRSVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC36</accession>
    <name>A0A2T4CC36_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC36"/>
    <dbReference type="STRING" id="983965.A0A2T4CC36"/>
    <dbReference type="OrthoDB" id="5215647at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="310" mass="35532" checksum="DE0C270677F43AAB" modified="2018-07-18" version="1">MDPNTPLKELDPQPIDSPASSRPFGITTAPPTTLPMRPAMDQPTNHSSGGMDLPRATPVSRSAEFRPSDFPPKPSNDYPRAASDYPKAHDFPPRPYEYPVQVPRPMQQLQSPYKPAVPQLGMEDVKASCQRNLKHLMYLQNQRRAFGYSSQAVDLEWQIRGQTGILIGELRTLQDGVRRMVKDAKNHRWRRWLFGGILATFIPAVRKLFRRGTDAESLVSSNNTEYAFRKSKGLLQRIKDSVLGHGRLASIAFFVFSVLYVFQNEVTLRVAKTVQKRLKKLSQRLEYSSQEIEERDLKALEGWRWRVILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CC41</accession>
    <name>A0A2T4CC41_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exocyst component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_64282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CC41"/>
    <dbReference type="STRING" id="983965.A0A2T4CC41"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="752" mass="87366" checksum="101A5F3610B20236" modified="2018-07-18" version="1">MDDAPVPKLSDLLRHPDDLDKIPALKLELSRKKSAVDGQLRNGLREQLETTQSGMNGLSDGQKAVQQIKEEMMKIDKLCSESQTMIKDFASINMVSQAHRNFGAVEAMRRNLETFNERLAVVERMLREDDDDNENMPNLLPCHYELTQLRNIRDDAMEQIQRAEDPSLESTLEDYFTRLDDTIDWFDEHVGILAMNLINLVVSDNNGLVVRFAVVMEAEEKSDQRVMALQEALKDHEEMAARFQGITDGARKVRGYMDKFMQAIKVSAEQQFQQAREDFLDDADGLEAAMKWFFNDLNAVKIGMTPLMPKKWRIAKTYADIYHVLMHDFLIGMVDDPEASSAHTLAIVSFPEKYYKKMAKLGFKQEDLVPHVIDNREAELVRDFRQLIIKFLDEWIDRIFEQEKRDFAERNTEGSNLDQDEYGYFRTKNLVALWRMLREQVEAAINSQRADVVEGVVDAMFLRLRSRQQSWQRMLDDEAERYESGRIPDLEGFQALQDWLVATANDQIAVIDDNEEENRLGYLSSFRQQFERNVGPQYLERTEQELNALRDGYVDFSTWCIHKFAHLVFVVDFKVVMPDFFTPKWYTNTAMKQMVVTFEEYVGEYRQALHHSLVDIFIEIFADELLVRYLSSVRNKGAKFRRVDPFRDKLFNDIATAFEYFSNLASPEVAMSIKDTWRVTEHFLALISVDKDSVAEAFAAFKSAYWDLQISWVEAVLRSRDDFERSMLNAVKARAAQMDVVRGPETVMAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCA3</accession>
    <name>A0A2T4CCA3_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M440DRAFT_1327550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCA3"/>
    <dbReference type="STRING" id="983965.A0A2T4CCA3"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PTB79176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="511" mass="56515" checksum="11CA65FBB12C4D9C" modified="2018-07-18" version="1">MSSGGAVASHGSSLGNFFQRFQGLQSHRNAMDDLIKDLLIHCNQVESDLREESKRLVSAHLDLANAVNAGRELQQVVEFYQEQEERTQERTVKEIEKIKKHNSYVMVLIDGDGLVFRESYIRQGVEGGKRAAYALRTAVADIFGEDAEDMEIVAKVVANLSGLGKAMQRDGCIDNPSLLKDFTLGFTQAKASFDYIDVGHGKERADSKIRETARWHLRNHNCRHILLGISHDSGYAPFLDETLQSEATRQRISIIEGVATVADLRATNVSIKKLGNELFREDKLHDKVPSPLQQHSVSAHSHAAQPPPAPQPAAREASPATSPVVSTASSKETRTPVVSYAGIASASPPPKITLPLARKQTQANGSDSSRNRGSQRSQQEAHYILIPPSQPQNWNPGPRGLDEPIRVNVQVLESVKKRKEDKLCNNHYLRGPCAKRDTCSFVHDHKITDDELKAVAVLARQNPCSSGQYCEADDCIYGHHCPSIRNGVCQHFHCRFSEDAHPPGTEYKGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCH1</accession>
    <name>A0A2T4CCH1_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M440DRAFT_232988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCH1"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PTB79263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="194" mass="21690" checksum="98A98CD9FDC3CAEE" modified="2018-07-18" version="1">MKAGRQASCWRRHSSMCSGCLAATYILAIEKTVIVISVHVAPIRRGRGALKRHPPEARSSRTKSHTLTEMDAIDSAICEPGRAWLPCHHHQLRLVTNRMLSRSASVCQWLFLPSLSNDRKSSARPTTSYGASLLGRLICLDEFGQKKRKMRYDSINDASYTAYGRDLFFVPSNSAGSYRLTFPISVVTALDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCH2</accession>
    <name>A0A2T4CCH2_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M440DRAFT_1326785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCH2"/>
    <dbReference type="STRING" id="983965.A0A2T4CCH2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PTB79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="293" mass="32917" checksum="CEF9DCDC57AE0B53" modified="2018-07-18" version="1">MSFPPNLKLNDGNEIPLLGYGLGTARFKRNQGPLDQELVDLTKRAIEIGYYHLDGAEVYGNEEELGAAIKASGVPREKLFVTTKISATEKKNTEEAFVLSLKKLGLDYVDLYLIHGPFFADSDEELQQKWADLEAIKASGRAKSIGVSNFLQEHLEVLLKTAKVPPAINQIEYHPYLQHGDLVAFHKEHNIAIASYGPLVPITRAQGGPVVPVYHRLAEKYGVTESDVGLRWVLDQGIVTLTTSSKESRLKGYLERLPKFTLEEDEVKEISAEGNKHHYRAFWTDKFAKDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCK6</accession>
    <name>A0A2T4CCK6_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M440DRAFT_1436623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CCK6"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="538"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="797"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="934"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1133"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1225"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1293"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1332"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1389"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1434"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PTB79307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1506" mass="166121" checksum="AABE6D5946C1BFE3" modified="2018-07-18" version="1">MSSTAVPYTVTFHRPGTEPPVFLAGDFESLEWGLQEMDFSRKDGGEYFFESRVFGEPGREYQFKFRAGKEGPWIVDENRAIATDAMGNRNNVLKMPKSYVPKLKGEEQRRTSTPIEQVASVAAEVADTAARLDEQDDSTPPISRSGGESEIDDELKTPLFAHECFGAYNFVDDALDHEALDDDKLRRESKPRFDEYNIDEVDINDPTIEAFPCEKTAIFSTLRKIQSSLAEDQAIADDTQASPRLDARRISVDSDDSLLSAGSLSPVTSRRRENRMSTGSNRNRSLVSLGSIAEEPKTPGLEEGSHPVAAGSYMKNGSGFGRAKIPYSITTPTSFDMRRAAANSVCLRCVHTIRTRPLLQPSLNSSILPTVQPQPCLGQRSLTQRARDRPSRMILADQVHKTPRLGRDDRKPRRERLAGPFAGMNRTVANIDPSRAAARARSADRKDSRDDGRRRPPNDRKALKMQRALESVSYSKRTSLKEKMQSFESFDQFDLLPALKTAVVDEVFAKMVDIRPTPVQRLAIPALLGQKEPEERRTQQQEGQSSFLLAAETGSGKTLAYLLPAIDALKRAEAEDPDIQAYKERAAIEKERQKAADFKGKPFEEPHPTMARPKVVVLVPTAELAHQVGLVAKKLSHAVKFKTEILSSNLKPQQIQRNLYGPKGLDLVISTPHLLASIADSDPNILSRVSHVIIDEADSLFDRSFSAVTSSIVERASPSMKQLICCSATIPRKLNNYLATNYPKMVRITTPNLHAIPRRVQLGVIDVSKDPYRNNKDLACADAIYTIGREASQHENLLKDEIDVRRIIVFVNEREKTEQVAEYLRSKGIDAQALHRDTPEKRHGETLETFTTPEPLRIIAPPNPSRKRSLANVKVLVVTDLASRGIDTLAVRHVILYDVPHTTIDFIHRLGRIVLVGNDDRRDVVADVKKSIAVAAPPPSSSPSTAVEQKPETRGRPRGRPRKNPPAAARPSINEKGTIQTADRSDDEALANEDVAMTSAVRTTRASSRSSIELGRFTAAATTTVTPGRNQRDTSGLDLGDSVFGDLDDSFAEGSVPGSALSGDVSNMSYSALRSQSRRSSFVGRNDPPIRPSSRTGNTPRVGSSFNLGLFKRRAREPSILGASRVPLQEPLTVEDSEADSEDDFEPEAESTPLNNRRRTQGHINNEGPASPDEAESSNSRKRKSLDTEQSSRGRPGKVSRTEPGPSRQPVDHDASQLPDAPPLSEDEQVGETSESELSEMSLPRDLPARLPPRPVTPVNQEEIVAPPASSGSEGPDVWPDIRTLAKKRRRPSVTTPTRLDNLSDMSSPPSLTHSPNYDAAKTGKPRGRPPQRQQESPKMTTADLTSLLPKRKYKKARDPLGLESDEELDTSGLGHEDDELSHLDTQTARRRKRGRPPTKARSASRGGKRTASSTRPTSYGHRSRHSSDKENADIDGTESENEGDEEGVSRFNPLADDTFDEAARGSADAVSTEELKQASNKFKEVDQWELDFEEVAEPSSPQDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCU1</accession>
    <name>A0A2T4CCU1_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein HSM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1327722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCU1"/>
    <dbReference type="STRING" id="983965.A0A2T4CCU1"/>
    <dbReference type="OrthoDB" id="4538483at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41580" checksum="D39170C173ED2C14" modified="2018-07-18" version="1">MSDRIIPNGSPDSHPISGLDDFQTHLRDLENDPSLPFNLKLLDDIELQLTESNIPPLLPTVLPPLTRLLKTTSQDPSPLLSLTIKLLSPLTFTRTLTIADPPSLLAALASPLPGANLLALAILHKAAKTPTEVALLSTLPDVVDALVTRWLDSPDVGVGERAAKVLGDLLETDCEVVREAPSPASSQNNTNGFQVYPAGAAAAANRRRIPGHGRLWRLILRERPTLERITTLCSPENTTTGTPPTRPRHQTSLSQGRLLRLLTRLATLNIRAISQTPFPELFPVSDAAAQALGRGLLQWAALSMVSKADDVLMHLNLIDFFETFVSLMRVAGLDAEEKSIVRTLVRVAAAEDGQLREALRGLPDRTVEEEAEPLRAYISDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CCW7</accession>
    <name>A0A2T4CCW7_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1398677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CCW7"/>
    <dbReference type="STRING" id="983965.A0A2T4CCW7"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7909" checksum="0603ACCCE12BA7AB" modified="2018-07-18" version="1">MTAAWKAAGLTYNRYLAVAARAIRRSLKEDKRIVAERRAVSELRFAVWKNGKPGETKDLAAANAAAMAESASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDB0</accession>
    <name>A0A2T4CDB0_TRILO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M440DRAFT_1326662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="983965.A0A2T4CDB0"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="8">
        <location>
            <begin position="384"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1347"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="787"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="968"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PTB79512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="1375" mass="148080" checksum="230EB060A35C4171" modified="2018-07-18" version="1">MKPSRLPSLLRQTASAQLRLRSSALLQRRSLSAAAGSHAIRNLLQVSGEVADAVASNKPVVALESTIYTHGALGKDLAQEHEDLVRSSGGIPAIIAVVEGVPKVGVSTEEIMRMIEDEGTVKASRRDIAYLVGMGLAGRKINGGTTIAGTMLLARLAGIRVFGTGGLGGVHRGGENSLDVSADLTELGRTRVAVVSSGCKGFLDIPRTLEFLETQGAYVGTYADGRAADAKVDFPAFWARDSGVRSPSVWRSEREAAAIILAQERLGIESGMLFANPIAEEFAIPAREMQGHIDQAVAEADQKGFTGSANTPYVLQRLKQLFGDRIVTANKQLVRANIVRATNIAVELSRLLKEGTSSSSGHKVAFGSKTENRSLAPSRANSKADILVAGSVAVDLSCDYTNPQGGDGQPQVHTSNPASISQSIGGVGHNVALAAHRASRQAQVKFSSMIGDDVAGATVLTALEASGLDSTYVKKLNQAEHPGSRTAQYVAINDSSKNLVMAMADMGIFTQHLFPEEWKAAIKATDPKWLVVDGNWSPKGIRTWIHAANEHGSKVAFEPVSVAKSKSLFGPQRGVPPLGVFPNQSVDLASPNIYELSAMYSAAKENGYLDSMEWFEVIDSFGMRGARDRFVRLTSAELTDAGVPVQSIQLLPYIPTIITKLGSKGVLLTTILSKEDPRLRDRESEEFILTRSFDGNPAVGGIYMRLFPPVEHVENIVSVNGVGDTFLGVMVSGLAQGGRVDKLVDVAQRGAVYTLKCAESVSKEVSKLESDLKKVALLNGTISAKMAQPQDPDFSEDELSENYVSSSDNDSDNAPSRKKPVVAMQEPDSDEEDLERLVFGSKVSFGESLFKAGSLIGTLDDKEGKELELADADTGGLEDVDDADLFMIDTAPSGAVPQATTVASKAKKAEHGDRPAWEDSDDDRLAISLANHTRLRKLRLTEAEDLVSGTEYSRRLRQRYLQLHPAPAWAKEAEGRPTKRRRRSSASSGSSDESGSESDGDVSAQPLEDFLRDVKSLSGAGGPKKRRLRPEIIDIQRTREISDTHLAPVECLSFHPEYPVLLSASTASVLYLHHIAPDAHPVPNPRLTSVQVKGVDIRRAEFLYPGGDKVFIGGRRRYFHHWDLKTGVVQKTSQILGHGLEHKTMERFRLSPCGRYMAITASTRKGGGIINVLSVGSLQWIAAARLSSRNGIADFAWWSTGNGMTILGKDGQVGEYSVETRSFVGLWRDDGCIGGIVIALGGHQGPEVIGDDRWVAIGSNSGITNIYDRSELLALDADKNIIIKEAPKPTRVFEQLVTPVTVLTFSPDGQLLAFGSRSSKDALRLAHLPSCTVYRNWPTAQTPLGRITAVAFGKDSSLLAVGNDTGKIRLWEIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDB4</accession>
    <name>A0A2T4CDB4_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M440DRAFT_1327163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Hypocreaceae</taxon>
            <taxon>Trichoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Multiple horizontal gene transfer events from other fungi enriched the ability of initially mycotrophic Trichoderma (Ascomycota) to feed on dead plant biomass.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Aerts A."/>
                <person name="Atanasova L."/>
                <person name="Chenthamara K."/>
                <person name="Zhang J."/>
                <person name="Grujic M."/>
                <person name="Henrissat B."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Lipzen A."/>
                <person name="Labutti K."/>
                <person name="Barry K."/>
                <person name="Miao Y."/>
                <person name="Rahimi M.J."/>
                <person name="Shen Q."/>
                <person name="Grigoriev I.V."/>
                <person name="Kubicek C.P."/>
                <person name="Druzhinina I.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 18648</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KZ679128">
        <property type="protein sequence ID" value="PTB79536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T4CDB4"/>
    <dbReference type="STRING" id="983965.A0A2T4CDB4"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000240760">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PTB79536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000240760"/>
        </source>
    </evidence>
    <sequence length="278" mass="31545" checksum="415372289FECCEC4" modified="2018-07-18" version="1">MADSGAGPSGDDIINSYHLPRPLPLWLNSNCAKHIVKGNFMTLSARPKTVEQGEWIAHQVVEHYRNLWNFVQVVHAKEETGNTICNPTTCPRMSAGANHSFTWLNSRREPVELPAHEYMTLMQRWITGKIDDTAIFPTDPAGVSYSHNPAITSTPLSQLTNPGEPDWVGKRSGFPEKFIDICQMIFRQMFRVYAHLYWAHFVEPYYHLNLEKQLNSCFSHFLLTATALDMLGKQELEPMQPLIDLWAANGTFPPESKVYEYASIRAGERLIQLAGVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T4CDJ5</accession>
    <name>A0A2T4CDJ5_TRILO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M440DRAFT_1176347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichoderma longibrachiatum ATCC 18648</name>
        <dbReference type="NCBI Taxonomy" id="983965"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
        
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